MedWorm: Appendix Cancer

Prognostic Significance of Lymph Node Metastases in Patients with High-Grade Appendiceal Cancer

Annals of Surgical Oncology — Tue, 12 Jul 2011 06:11:30 +0100

Conclusions Patient selection for CRS/HIPEC should take into consideration LN status, but it should not be a contraindication if preoperative evaluation revealed a high likelihood of complete cytoreduction. Content Type Journal ArticlePages 1-4DOI 10.1245/s10434-011-1903-0Authors Hatem El Halabi, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USAVadim Gushchin, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USAJennifer Francis, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USANicholas Athas, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USARyan MacDonald, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USACarol Nieroda, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USAKimberly Studeman, Surgical Oncology, Mercy ...

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The Role of Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy (CRS/HIPEC) in Patients with High-Grade Appendiceal Carcinoma and Extensive Peritoneal Carcinomatosis

Annals of Surgical Oncology — Fri, 24 Jun 2011 05:43:41 +0100

Conclusions Meaningful long-term survival could be achieved in patients with PMCA even with extensive peritoneal disease. PCI ≥ 20 should not be used as an exclusion criterion when selecting these patients for CRS/HIPEC, and every effort should be made to achieve complete cytoreduction. Content Type Journal ArticlePages 1-5DOI 10.1245/s10434-011-1840-yAuthors Hatem El Halabi, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USAVadim Gushchin, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USAJennifer Francis, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USANicholas Athas, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USARyan MacDonald, Surgical Oncology, Mercy Medical Center, Baltimore, MD, USACarol Nieroda, Surgical ...

Surgical Cytoreduction and Survival in Appendiceal Cancer Peritoneal Carcinomatosis: An Evaluation of 46 Consecutive Patients

Annals of Surgical Oncology — Thu, 14 Apr 2011 05:50:17 +0100

Conclusions Cytoreductive surgery and intraperitoneal chemotherapy may achieve long-term survival in appendiceal malignancies with peritoneal dissemination for which the predictors of outcomes identified through this study may tailor the disease management to commit patients early toward this successful surgical strategy. Content Type Journal ArticlePages 1-7DOI 10.1245/s10434-011-1714-3Authors Terence C. Chua, Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, AustraliaIhssan Al-Alem, Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, AustraliaAkshat Saxena, Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Sydney, NSW, Aus...

Peritoneal Carcinomatosis from Appendiceal Cancer: Early Adequate Therapeutic Management for Long-Term Survival

Annals of Surgical Oncology — Wed, 13 Apr 2011 14:33:50 +0100

Content Type Journal ArticlePages 1-2DOI 10.1245/s10434-011-1718-zAuthors Olivier Glehen, Surgical Oncology Department, Centre Hospitalo-Universitaire Lyon Sud, Lyon, FranceNaoual Bakrin, Surgical Oncology Department, Centre Hospitalo-Universitaire Lyon Sud, Lyon, FranceGuillaume Passot, Surgical Oncology Department, Centre Hospitalo-Universitaire Lyon Sud, Lyon, France Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

Duplicated appendix complicated by appendiceal cancer.

World Journal of Gastroenterology : WJG — Fri, 07 Jan 2011 00:00:00 +0100

Authors: Freeman HJ A 37-year old male presented with an acute abdomen suggestive of an appendiceal perforation. Urgent laparotomy showed a duplicated appendix with one of the lumens involved with appendicitis and a focal peri-appendicular abscess while the other lumen had a localized appendiceal cancer. Recognition of congenital intestinal duplications in adults is important to avoid serious clinical consequences. PMID: 21218095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Changes induced by surgical and clinical factors in the pharmacology of intraperitoneal mitomycin C in 145 patients with peritoneal carcinomatosis

Cancer Chemotherapy and Pharmacology — Mon, 20 Sep 2010 19:29:14 +0100

Conclusions Surgical and clinical factors may require modifications of drug dose or timing of chemotherapy administration. A large visceral resection and a contracted peritoneal space caused a reduced mitomycin C clearance. Total diffusion surface is an important determinant of mitomycin C pharmacokinetics. Content Type Journal ArticleDOI 10.1007/s00280-010-1460-4Authors Kurt Van der Speeten, Department of Surgical Oncology, Ziekenhuis Oost-Limburg, Genk, BelgiumO. Anthony Stuart, Washington Cancer Institute, Washington Hospital Center, 106 Irving Street, NW, Suite 3900, Washington, DC 20010, USADavid Chang, Westat, Rockville, MD USAHaile Mahteme, Department of Surgical Sciences, Akademiska Sjukhuset, Uppsala, SwedenPaul H. Sugarbaker, Washington Cancer Institute, W...

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Post-Menopausal Vaginal Bleeding Caused by Carcinoma of The Appendix: A Case Report

Medscape Today Headlines — Tue, 13 Jul 2010 10:36:28 +0100

While post-menopausal vaginal bleeding is not uncommon, its origin in this patient with a previous hysterectomy was quite unexpected. Journal of Medical Case Reports (Source: Medscape Today Headlines)

Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report

BioMed Central — Sat, 01 May 2010 23:00:00 +0100

Conclusion: Post-menopausal blood loss in a patient with a history of hysterectomy is uncommon and always needs further investigation. (Source: BioMed Central)

Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation

BMC Cancer — Tue, 23 Feb 2010 00:00:00 +0100

Conclusions: The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder. (Source: BMC Cancer)

[Multiple primary neoplasms - coincidence or tumor syndrom?]

Praxis — Tue, 08 Sep 2009 23:00:00 +0100

We present the history of an actually asymptomatic female patient with four different malignancies within 30 years: malignant melanoma (1976), liposarcoma (1983), carcinoma of the appendix (2006) and lymphoma (2006). Discussion: There is not only a remarkable variety of malignant tumors but also an extraordinary long survival without recurrence of the generalised malignomas of the skin and soft tissue (malignant melanoma and liposarcoma). It is difficult to explain the entire restitution with the implemented treatments (several tumor resections, chemotherapy with Ifosfamide). More than 20 years after chemotherapy, the lymphoma can be classified as a secondary malignoma. We discuss the pathogenesis of multiple malignomas in further details. PMID: 19739050 [PubMed - in process] (Source: ...

Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C

Annals of Surgical Oncology — Thu, 28 May 2009 09:13:10 +0100

Conclusion Neutropenia is a frequent complication associated with MMC-HIPEC. Female sex and MMC dose per BSA are independent risk factors for neutropenia. These differences must be considered in the management of patients undergoing MMC-HIPEC to minimize the toxicity of the procedure. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0523-4Authors Laura A. Lambert, The University of Texas M.D. Anderson Cancer Center Department of Surgical Oncology Houston TX USATerri S. Armstrong, University of Texas–Houston School of Nursing Houston TX USAJ. Jack Lee, The University of Texas M.D. Anderson Cancer Center Department of Biostatistics Houston TX USASuyu Liu, The University of Texas M.D. Anderson Cancer Center Department of Biostatistic...

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Epithelial Appendiceal Neoplasms.

Cancer Journal — Thu, 30 Apr 2009 23:00:00 +0100

Authors: Sugarbaker PH The appendiceal malignancies usually arise within a mucocele. The tumor within this structure can be minimally aggressive or of an invasive character. If a low-grade appendiceal malignancy is removed intact, recurrence does not occur. If rupture of the wall of the mucocele occurs with either low-grade or high-grade disease, the epithelial cells within will disseminate to the peritoneal surfaces. Sometimes a second-look surgery must be performed to determine if intraperitoneal spread of mucus and cancer cells has occurred. If the diagnosis of peritoneal dissemination of an appendiceal malignancy has been established, a new treatment with curative intent is indicated. Cytoreductive surgery is combined with perioperative intraperitoneal chemotherapy as a comprehensi...

The Current Role of Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Dissemination of Appendiceal Tumors

Current Problems in Cancer — Thu, 30 Apr 2009 23:00:00 +0100

Appendiceal malignancies are rare with an age-adjusted incidence of about 0.12 cases per 1 million individuals per year. Appendiceal tumors are infrequently diagnosed before surgery and often present with peritoneal dissemination. In cases with low-grade cytology, this peritoneal dissemination is hypothesized to arise from perforation of the appendiceal tumor and subsequent dissemination of mucous-producing adenomatous epithelial cells throughout the abdomen and pelvis. This may lead to mucinous ascites or pseudomyxoma peritonei (PMP). In cases with high-grade cytology, the peritoneal dissemination is usually seen in association with an invasive mucinous carcinoma of the appendix. (Source: Current Problems in Cancer)

Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: Report of a case

Surgery Today — Thu, 12 Mar 2009 10:24:48 +0100

We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass. Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases. We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made. Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases. When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00595-008-3839-yAuthors Jun S...

Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

World Journal of Surgical Oncology — Thu, 08 Jan 2009 05:00:00 +0100

Conclusions: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide a promising combined treatment strategy for selected patients with peritoneal carcinomatosis that can improve patient survival and quality of life. The extent of intraperitoneal tumor dissemination and the completeness of cytoreduction are the leading predictors of postoperative patient outcome. Thus, consistent preoperative diagnostics and patient selection are crucial to obtain a complete macroscopic cytoreduction (CCR-0/1). (Source: World Journal of Surgical Oncology)

Early carcinoma of the appendix vermiformis

Digestive Endoscopy — Mon, 22 Dec 2008 05:00:00 +0100

It is difficult to preoperatively diagnose early carcinoma of the vermiform appendix because of its rarity and few specific clinical features. In the present study, we report a preoperatively diagnosed mucosal carcinoma of the vermiform appendix. (Source: Digestive Endoscopy)

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Adenocarcinoma of the Appendix Is Rarely Detected by Colonoscopy

Journal of Gastrointestinal Surgery — Wed, 17 Dec 2008 09:29:16 +0100

Conclusions Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma. We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy. Content Type Journal ArticleDOI 10.1007/s11605-008-0774-6Authors Apurva N. Trivedi, Wake Forest University Baptist Medical Center Section of Gastroenterology Medical Center Blvd Winston-Salem NC 27157 USAEdward A. Levine, Wake Forest University Baptist Medical Center Department of General Surgery Winston-Salem NC USAGirish Mishra, Wake Forest University Baptist Medical Center Section of Gastroenterology Medical Center Blv...

Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines.

The American Surgeon — Sat, 01 Nov 2008 04:00:00 +0100

This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy was performed in 33.4 per cent, which does not follow the current guidelines. In this group, 5-year survival was significantly less for patients with Stage III and IV dise...

Primary signet ring cell carcinoma of the appendix: A rare case report and our 18-year experience.

World Journal of Gastroenterology : WJG — Tue, 07 Oct 2008 04:00:00 +0100

Authors: Ko YH, Jung CK, Oh SN, Kim TH, Won HS, Kang JH, Kim HJ, Kang WK, Oh ST, Hong YS Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 c...

Consensus guidelines for the management of patients with digestive neuroendocrine tumours - well-differentiated tumour carcinoma of the appendix

Thu, 01 May 2008 17:24:56 +0100

Aims: This is the most up to date guideline for the management of patients with neuroendocrine tumours. This consensus document has been produced under the auspices of the European Neuroendocrine Tumour Society. Intended audience: All healthcare professionals involved in managing patients with digestive NETs. (Source: NHS Evidence - gastroenterology and liver diseases - Updates for Neuroendocrine Tumours)

Researchers Study New Drug And Indications For Heated Chemotherapy Treatment

Cancercompass News: Colorectal Cancer — Sat, 05 Apr 2008 04:24:01 +0100

Studies have shown that surgery combined with Intraperitoneal Hyperthermic Chemotherapy (IPHC) can improve survival rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. Researchers from Wake Forest University School of Medicine will present findings from two studies on the use of IPHC in treating peritoneal cancer that has spread from these two primary cancer sites at the annual meeting of the Society of Surgical Oncology in Chicago, March 13-16. John H. Stewart, IV, M.D., assistant professor of surgery, section of surgical oncology, reports March 13 on the results of a study evaluating toxicity when combining surgery and IPHC using oxali... (Source: Cancercompass News: Colorectal Cancer)

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Studies Review New Drug And Indications For Heated Chemotherapy

Cancer / Oncology News From Medical News Today — Sat, 15 Mar 2008 07:00:00 +0100

Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitis

Radiation Medicine — Wed, 27 Feb 2008 15:50:28 +0100

Conclusion CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11604-007-0196-5Authors Motoki Kaidu, Sado General Hospital Department of Diagnostic Imaging and Internal Medicine 113-1 Chigusa Sado 952-1209 JapanManabu Oyamatu, Sado General Hospital Department of Surgery Sado JapanKenji Sato, Sado General Hospital Department of Surgery Sado JapanAkira Saitou, Niigata Diagnostic Imaging Center Niigata JapanSatoshi Yamamoto, Niigata University Department of Radiol...

[Treatment of peritoneal carcinomatosis with surgery and hyperthermic peroperative intraperitoneal chemotherapy (HIPEC): new aspects and validated indications]

Bulletin du Cancer — Tue, 01 Jan 2008 05:00:00 +0100

Authors: Eveno C, Dagois S, Guillot E, Gornet JM, Pocard M Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is now an entire part of treatment of peritoneal dissemination of colorectal malignancy, and it's possible to hope prolonged survival. This treatment is more and more codified. Four indications are recognized by some tree national evaluation committees: the French ANAES, the British NICE and the Canadian CEPO: colorectal carcinoma, carcinoma of the appendix, pseudomyxoma peritonei and mesothelioma. Last big published series results show a decrease of morbidity and mortality and interest of using new drugs like oxaliplatine. Indications have to be more homogeneous and based on evidences. PMID: 18230580 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)

Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center

Annals of Surgical Oncology — Fri, 14 Dec 2007 15:57:46 +0100

Conclusions In a high-volume center with extensive experience treating peritoneal malignancies, perioperative mortality can be lowered to nearly zero, although morbidity remains high. CS-HIPEC procedures should be studied further in a controlled manner to help define their important role in the care of patients with PC. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-007-9701-4Authors Niraj J. Gusani, University of Pittsburgh Medical Center Division of Surgical Oncology, Department of Surgery Pittsburgh Pennsylvania USASung W. Cho, University of Pittsburgh Medical Center Division of Surgical Oncology, Department of Surgery Pittsburgh Pennsylvania USAChristos Colovos, University of Pittsburgh Medical Center Division of Surgical Oncology...

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Survival and Health Outcomes After Cytoreductive Surgery With Intraperitoneal Hyperthermic Chemotherapy for Disseminated Peritoneal Cancer of Appendiceal Origin

Annals of Surgical Oncology — Wed, 21 Nov 2007 16:41:51 +0100

Conclusions Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year. Depressive symptoms and some physical limitations remain in surviving patients. Content Type Journal ArticleCategory Healthcare Policy and OutcomesDOI 10.1245/s10434-007-9678-zAuthors Richard P. McQuellon, Wake Forest University School of Medicine Department of Internal Medicine, Section of Hematology and Oncology Medical Center Blvd Winston-Salem North Carolina 27157-1082 USAGregory B. Russell, Wake Forest University School of Medicine Department of Biostatistical Sciences, Section of Biostatistics Medical Center Blvd Winston-Salem North Carolina 27157-1082 USAPer...

Treatment of patients with appendiceal cancer and peritoneal dissemination.

Gynecologic Oncology — Mon, 10 Sep 2007 04:00:00 +0100

Authors: van Nagell JR, Desimone CP PMID: 17850854 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Carcinoma of the appendix: Report of two cases

Diseases of the Colon & Rectum — Sat, 24 Mar 2007 10:28:27 +0100

Content TypeJournal Article JournalDiseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 Journal VolumeVolume 17 Journal IssueVolume 17, Number 3 / May, 1974 (Source: Diseases of the Colon & Rectum)

Signet ring cell carcinoma of the appendix presenting with intestinal obstruction

Indian Journal of Surgery — Sat, 17 Feb 2007 04:20:02 +0100

We report our patient who presented with intestinal obstruction due to a signet ring cell carcinoma of the appendix, (studies proved that it was not a primary colonic lesion invading the appendix) and review literature of this very uncommon lesion. (Source: Indian Journal of Surgery)

Perioperative intraperitoneal chemotherapy for peritoneal surface malignancy

Journal of Translational Medicine — Mon, 10 Apr 2006 06:00:00 +0100

The treatment of peritoneal surface malignancy mainly focuses on diffuse malignant peritoneal mesothelioma, pseudomyxoma peritonei from appendiceal cancer, and peritoneal dissemination from gastrointestinal and ovarian cancers. Cancer progression causes peritoneal implants to be distributed throughout the abdominopelvic cavity. These nodules plus the ascitic fluid result in abdominal distension. As the disease progresses, these tumors cause intestinal obstruction leading to debilitating symptoms and a greatly impaired quality of life. In the past, the prognosis of patients with peritoneal surface malignancy was regarded dismal and cure was not an option. Recently, cytoreductive surgery combined with perioperative intraperitoneal chemotherapy has shown an improved survival in selected patie...

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