MedWorm: Basal Cell Carcinoma

A 68-Year-Old Woman Presents With Scalp Mass, Biopsy Reveals Basal Cell Carcinoma

Cancer Network — Mon, 06 Feb 2012 12:00:00 +0100

A 68-year-old woman presented with a mass on the scalp which had been present for approximately 7 years. An incisional biopsy of the scalp mass and excisional biopsy of the lymph node both revealed basal cell carcinoma, micronodular histologic subtype. (Source: Cancer Network)

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In vivo measurements of diffuse reflectance and time‐resolved autofluorescence emission spectra of basal cell carcinomas

Journal of Biophotonics — Mon, 06 Feb 2012 05:00:00 +0100

We present a clinical investigation of diffuse reflectance and time‐resolved autofluorescence spectra of skin cancer with an emphasis on basal cell carcinoma. A total of 25 patients were measured using a compact steady‐state diffuse reflectance/fluorescence spectrometer and a fibre‐optic‐coupled multispectral time‐resolved spectrofluorometer. Measurements were performed in vivo prior to surgical excision of the investigated region. Singular value decomposition was used to reduce the dimensionality of steady state diffuse reflectance and fluorescence spectra. Linear discriminant analysis was then applied to the measurements of basal cell carcinomas (BCCs) and used to predict the tissue disease state with a leave‐one‐out methodology. This approach was able to correctly diagnose...

High and sustained efficacy after two sessions of topical 5‐aminolaevulinic acid photodynamic therapy for basal cell carcinoma: a prospective, clinical and histological 10‐year follow–up study

British Journal of Dermatology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion: Two sessions of DMSO supportive topical ALA‐PDT and curettage can provide long‐term effective treatment results with favourable cosmetic outcome in primary, small BCC. (Source: British Journal of Dermatology)

Basal Cell Carcinoma of the Scrotum: Clinicopathologic Analysis of 10 Cases

Dermatologic Surgery — Mon, 06 Feb 2012 05:00:00 +0100

ConclusionsBCC of the scrotum is rare. It can metastasize after a long period of initial therapy. Long‐term surveillance including a complete metastatic examination is recommended for these patients. (Source: Dermatologic Surgery)

Dermoscopy of Small Basal Cell Carcinoma: Study of 100 Lesions 5 mm or Less in Diameter

Dermatologic Surgery — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Dermatologic Surgery)

Vismodegib approved by US FDA for treatment of basal cell carcinoma

MedWire News - Oncology — Fri, 03 Feb 2012 00:00:00 +0100

The US Food and Drug Administration has approved vismodegib for treatment of metastatic basal cell carcinoma. (Source: MedWire News - Oncology)

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An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation

Acta Neuropathologica — Thu, 02 Feb 2012 18:15:33 +0100

Abstract Development of the cerebellum occurs postnatally and is marked by a rapid proliferation of cerebellar granule neuron precursors (CGNPs). CGNPs are the cells of origin for SHH-driven medulloblastoma, the most common malignant brain tumor in children. Here, we investigated the role of ERK, JNK, and p38 mitogen-activated protein kinases in CGNP proliferation. We found high levels of p38α in proliferating CGNPs. Concomitantly, members of the p38 pathway, such as ASK1, MKK3 and ATF-2, were also elevated. Inhibition of the Shh pathway or CGNP proliferation blunts p38α levels, irrespective of Shh treatment. Strikingly, p38α levels were high in vivo in the external granule layer of the postnatal cerebellum, Shh-dependent mouse medulloblastomas and human medulloblastoma...

Intralesional cryosurgery for the treatment of basal cell carcinoma in an elderly patient

European Journal of Plastic Surgery — Thu, 02 Feb 2012 18:13:17 +0100

Abstract The incidence of basal cell carcinoma (BCC) on the lower extremities of elderly patients, who have co-morbidity, is rising. The surgical technique to treat those skin neoplasms on the legs should take into account difficulties in wound healing, dehiscence, or necrosis of the surgical wound, failed skin grafting, and wound infection due to blood supply and innervation disturbances and reduced quality of the skin. Spray/contact cryosurgery is one of the well-established, older therapies for BCC and is widely used with hardly any contraindications and with a high cure rate. This case report is the first in the medical literature to present a successful removal of two BCCs on the leg of an elderly patient by employing a novel and new intralesional cryosurgery technolo...

Ber‐EP4 is a useful marker for follicular germinative cell differentiation of cutaneous epithelial neoplasms

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

In this study, we performed immunohistochemical staining of 31 cases of basal cell carcinoma (BCC); 20 cases of trichoblastoma (TB), including ten cases of nodular type, eight cases of cribriform type (trichoepithelioma) and two cases of columnar type (desmoplastic trichoepithelioma); 16 cases of actinic keratosis (AK); and 10 cases each of Bowen’s disease, poroma and seborrheic keratosis. Six cases of BCC and AK were co‐lesions of both neoplasms. In normal skin tissue, Ber‐EP4 reacted positively with the secretory portion of eccrine glands and follicular germinative cells at the lower end of catagen hairs. Neoplastic cells in 97% of cases with BCC reacted positively with Ber‐EP4 in at least 5% of neoplastic cells. Those in 90% with nodular type TB and 50% with trichoepithelioma al...

Erivedge - Treatment For Most Common Form Of Skin Cancer

Health News from Medical News Today — Wed, 01 Feb 2012 17:00:00 +0100

Basal cell carcinoma is a form of skin cancer caused by regular sun exposure, or other ultraviolet radiation, which starts in the top layer of the skin (epidermis), is usually painless and grows slowly. The U.S. Food and Drug Administration just approved a new drug named Erivedge (vismodegib) for the treatment of adult patients with basal cell carcinoma, the most common type of skin cancer. The drug is designed for use in patients with locally advanced basal cell cancer, whose cancer has spread to other locations in the body, and who are unsuitable candidates for surgery or radiation... (Source: Health News from Medical News Today)

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Med Sci Monit 2012; 18(2):PI5-9 "The application of Levulan®-based photodynamic therapy with imiquimod in the treatment of recurrent basal cell carcinoma"

Medical Science Monitor — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: Cure was achieved without any scarring and with very good cosmetic effects. Although this is the preliminary report, the presented modification of PDT seems to be reasonable and promising in treating basal-cell carcinoma. (Source: Medical Science Monitor)

Hedgehog‐EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour‐initiating pancreatic cancer cells

EMBO Molecular Medicine — Wed, 01 Feb 2012 05:00:00 +0100

In this report we show that genetic and pharmacologic inhibition of EGFR signalling reduces tumour growth in mouse models of HH/GLI driven basal cell carcinoma (BCC). We describe HH‐EGFR cooperation response genes including SOX2, SOX9, JUN, CXCR4 and FGF19 that are synergistically activated by HH‐EGFR signal integration and required for in vivo growth of BCC cells and tumour‐initiating pancreatic cancer cells. The data validate EGFR signalling as drug target in HH/GLI driven cancers and shed light on the molecular processes controlled by HH‐EGFR signal cooperation, providing new therapeutic strategies based on combined targeting of HH‐EGFR signalling and selected downstream target genes. (Source: EMBO Molecular Medicine)

Unique features of PTCH1 mutation spectrum in Chinese sporadic basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion Mutations and LOH in PTCH1 were also highly prevalent in Chinese sporadic BCCs. However, UV light plays a less role in causing these mutations, suggesting other potential mechanisms in the development of sporadic BCC in Chinese patients. (Source: Journal of the European Academy of Dermatology and Venereology)

FDA approves Roche skin cancer drug Erivedge

CTV Health — Tue, 31 Jan 2012 14:20:28 +0100

Federal regulators on Monday approved a pill that treats the most common type of skin cancer, basal cell carcinoma. The pill is called Erivedge and is made by Genentech, a unit of Swiss drugmaker Roche. (Source: CTV Health)

Vismodegib Granted FDA Approval for Treatment of Basal Cell Carcinoma

Cancer Network — Tue, 31 Jan 2012 12:00:00 +0100

The U.S. Food and Drug Administration (FDA) announced the approval of vismodegib (Erivedge), for the treatment of advanced basal cell carcinoma, the most common type of skin cancer, for patients who are not eligible for surgery or radiation, and for metastatic disease. (Source: Cancer Network)

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FDA Approves Drug For Common Skin Cancer

Health News from Medical News Today — Tue, 31 Jan 2012 10:00:00 +0100

On Monday, the US Food and Drug Administration approved a new type of drug to treat adult patients with advanced basal-cell carcinoma, the most common type of skin cancer. The drug's generic name is vismodegib and was developed by the US part of Roche Holding AG. It will be sold in the US by Roche's South San Francisco-based Genentech under the brand name Erivedge. Basal cell carcinoma is a slow growing, painless cancer that starts in the epidermis, the top layer of skin. It usually starts in places that are regularly exposed to the sun or UV light... (Source: Health News from Medical News Today)

Erivedge Approved to Treat Basal Cell Carcinoma

MedicineNet Skin General — Tue, 31 Jan 2012 07:00:00 +0100

Title: Erivedge Approved to Treat Basal Cell CarcinomaCategory: Health NewsCreated: 1/30/2012 4:06:00 PMLast Editorial Review: 1/31/2012 (Source: MedicineNet Skin General)

Skin Cancer Drug Erivedge Approved

WebMD Health — Tue, 31 Jan 2012 05:00:00 +0100

The FDA has approved Erivedge, a once-daily pill that can shrink disfiguring or metastatic basal cell carcinoma (BCC) tumors. (Source: WebMD Health)

FDA approves vismodegib for treating basal cell skin cancer

Drug Topics - Top News — Tue, 31 Jan 2012 05:00:00 +0100

FDA has approved vismodegib (Erivedge, Curtis and Genentech, a member of the Roche Group) for the treatment of adult patients with basal cell carcinoma, the most common type of skin cancer. (Source: Drug Topics - Top News)

Arsenic and Basal Cell Carcinoma in Areas of Hungary, Romania, and Slovakia: A Case-Control Study

EHP-in-Press — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion: We found a positive association between BCC and exposure to As through drinking water with concentrations below 100 µg/L. (Source: EHP-in-Press)

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FDA Okays First Drug for Basal Cell Cancer

MedPage Today Campaign '08 — Mon, 30 Jan 2012 23:43:58 +0100

WASHINGTON (MedPage Today) -- The FDA has approved the first drug for treatment of basal cell carcinoma, the most common type of skin cancer. (Source: MedPage Today Campaign '08)

Prescriptions Blog: F.D.A. Approves Drug for an Advanced Skin Cancer

NYT Health — Mon, 30 Jan 2012 20:44:47 +0100

The drug, Erivedge, made by Genentech, was approved for adults with basal cell carcinoma that has spread elsewhere in the body or those who are not candidates for surgery or radiation. (Source: NYT Health)

FDA Approves Vismodegib for Advanced Basal Cell CarcinomaFDA Approves Vismodegib for Advanced Basal Cell Carcinoma

Medscape Today Headlines — Mon, 30 Jan 2012 19:23:41 +0100

The FDA has approved vismodegib for the treatment of locally advanced or metastatic basal cell carcinoma. FDA Approvals (Source: Medscape Today Headlines)

FDA approves Erivedge for most common type of skin cancer

Health News: CBSNews.com — Mon, 30 Jan 2012 18:19:11 +0100

Pill is first drug ever approved to treat basal cell carcinoma; BCC strikes 2.8 million Americans each year (Source: Health News: CBSNews.com)

FDA approves Roche skin cancer drug

Reuters: Health — Mon, 30 Jan 2012 17:57:58 +0100

(Reuters) - U.S. health regulators on Monday approved Roche's pill to treat an advanced form of the most common form of skin cancer, known as basal cell carcinoma. (Source: Reuters: Health)

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FDA approves Roche skin cancer drug Erivedge

USATODAY.com Health — Mon, 30 Jan 2012 17:32:32 +0100

Federal regulators on Monday approved a pill that treats the most common type of skin cancer, basal cell carcinoma.. (Source: USATODAY.com Health)

FDA Approves Erivedge for Basal Cell Carcinoma

Drugs.com - New Drug Approvals — Mon, 30 Jan 2012 17:01:36 +0100

SILVER SPRING, Md., Jan. 30, 2012 /PRNewswire-USNewswire/ -- Today, Erivedge (vismodegib) was approved by the U.S. Food and Drug Administration to treat adult patients with basal cell carcinoma, the most common type of skin cancer. The drug is... (Source: Drugs.com - New Drug Approvals)

FDA approves Erivedge (vismodegib) capsule, the first medicine for adults with advanced basal cell carcinoma

Roche Media News — Mon, 30 Jan 2012 17:00:00 +0100

Roche today announced that Erivedge (vismodegib) capsule was approved by the U.S. Food and Drug Administration (FDA) for adults with a type of skin cancer, called basal cell carcinoma (BCC), that has spread to other parts of the body or that has come back after surgery or that their healthcare provider decides cannot be treated with surgery or radiation. (Source: Roche Media News)

FDA approves first drug for metastatic basal cell carcinoma

HemOncToday.com — Mon, 30 Jan 2012 16:06:00 +0100

(Source: HemOncToday.com)

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FDA approves new treatment for most common type of skin cancer

Food and Drug Administration — Mon, 30 Jan 2012 15:58:00 +0100

Today, Erivedge (vismodegib) was approved by the U.S. Food and Drug Administration to treat adult patients with basal cell carcinoma, the most common type of skin cancer. The drug is intended for use in patients with locally advanced basal cell cancer who are not candidates for surgery or radiation and for patients whose cancer has spread to other parts of the body (metastatic). (Source: Food and Drug Administration)

FDA Approves Erivedge (vismodegib) Capsule, The First Medicine For Adults With Advanced Basal Cell Carcinoma

Pharmaceutical Online News — Mon, 30 Jan 2012 08:31:00 +0100

Roche recently announced that Erivedge (vismodegib) capsule was approved by the U.S. Food and Drug Administration (FDA) for adults with a type of skin cancer, called basal cell carcinoma (BCC), that has spread to other parts of the body or that has come back after surgery or that their healthcare provider decides cannot be treated with surgery or radiation. (Source: Pharmaceutical Online News)

Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases.

Journal of Cutaneous Pathology — Mon, 30 Jan 2012 06:28:50 +0100

We present a series of seven desmoplastic trichoepitheliomas with otherwise typical presentation and morphology, nevertheless demonstrating epithelium present in the perineural spaces of adjacent small dermal nerves. Patients ranged in age from 14 to 66 years (mean 44 years). All seven tumors were restricted to dermis, showed strands of basaloid epithelium in desmoplastic stroma, and contained CK20‐positive cells. Additionally, five of five examined tumors displayed diffuse expression of p75 neurotrophin receptor. Five patients were followed‐up clinically (follow‐up time range: 2 months ‐ 4 years). No tumor recurrence was observed in any of these patients. We postulate that perineural involvement is an unusual feature of desmoplastic trichoepithelioma that should not be equated wit...

Cutaneous Malignancies of the Upper Extremity

The Journal of Hand Surgery — Fri, 27 Jan 2012 11:25:00 +0100

This article reviews diagnosis and treatment, including margin of resection and need for sentinel lymph node biopsy, for the 3 most common cutaneous malignancies: basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. (Source: The Journal of Hand Surgery)

Fibroblasts prepared from different types of malignant tumors stimulate expression of luminal marker keratin 8 in the EM-G3 breast cancer cell line

Histochemistry and Cell Biology — Tue, 24 Jan 2012 07:26:57 +0100

In conclusion, our data indicate that CAFs are able to influence the phenotype of a breast cancer cell line and this effect is based on a tumor type-unspecific mechanism. Finally, a clear functional difference between normal and CAFs was demonstrated. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00418-012-0918-3Authors B. Dvořánková, 1st Faculty of Medicine, Institute of Anatomy, Charles University, U nemocnice 3, 12800 Prague 2, Czech RepublicP. Szabo, 1st Faculty of Medicine, Institute of Anatomy, Charles University, U nemocnice 3, 12800 Prague 2, Czech RepublicL. Lacina, 1st Faculty of Medicine, Institute of Anatomy, Charles University, U nemocnice 3, 12800 Prague 2, Czech RepublicO. Kodet, 1st Faculty of Medicine, Institute of Anatomy, Charles Un...

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Rare case of basal cell carcinoma arising in a nevus sebaceous on the upper arm

The Journal of Dermatology — Thu, 19 Jan 2012 05:00:00 +0100

(Source: The Journal of Dermatology)

Plasmacytoid DCs: Tumor-killing Immune Cells

Health News from Medical News Today — Wed, 18 Jan 2012 10:00:00 +0100

Some skin cancers, in particular basal cell carcinoma, can be successfully treated with a prescription cream containing the compound imiquimod. The antitumor effect of imiquimod is multifactorial. One of the more complex aspects of imiquimod's antitumor effects is its ability to modify the immune response. A team of researchers led by Maria Sibilia, at the Medical University of Vienna, Austria, has now identified a new way in which imiquimod modifies the immune system to clear tumors in a mouse model of melanoma, the most deadly form of skin cancer... (Source: Health News from Medical News Today)

Response to the Article: «Efficacy of Curettage-Electrodesiccation for Basal Cell Carcinoma in Medium- and High-Risk Areas»

Actas Dermo-Sifiliograficas — Wed, 18 Jan 2012 05:00:00 +0100

Authors: Aguayo-Leiva IR, Ríos-Buceta L, Jaén-Olasolo P PMID: 22264519 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Performance of a simple chromatin-rich segmentation algorithm in quantifying basal cell carcinoma from histology images

BioMed Central — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions: The proposed image analysis algorithm demonstrates the feasibility of automatically extracting tumour regions from digitized basal cell carcinoma histology slides. The proposed algorithm may be adaptable to other stain combinations and tumour types. (Source: BioMed Central)

Clinicopathological evaluation of nonmelanoma skin cancer

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion: NMSC often associated with greater morbidity, necessitating increased efforts to assess risk factors in individuals, to encourage periodic self-examination and professional evaluation of skin and to optimize strategies for earlier diagnosis and treatment. (Source: Indian Journal of Dermatology)

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Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

British Journal of Dermatology — Fri, 13 Jan 2012 05:00:00 +0100

Conclusions: Reduction of Langerhans cells during clinical treatment of BCC might potentially impact negatively on anti‐tumour responses through reduced activation of tumour‐specific effector cells. Investigation of modified PDT protocols with the aim to minimise immunosuppressive effects whilst maintaining anti‐tumour efficacy is warranted. (Source: British Journal of Dermatology)

Nationwide survey of nevoid basal cell carcinoma syndrome in Japan revealing the low frequency of basal cell carcinoma

American Journal of Medical Genetics Part A — Fri, 13 Jan 2012 05:00:00 +0100

AbstractNevoid basal cell carcinoma syndrome (NBCCS) is characterized by developmental defects and tumorigenesis. The clinical manifestations of NBCCS have been reported in large epidemiological studies from the United States, the United Kingdom, and Australia, but not from an Asian country. We conducted a nationwide survey and identified 311 NBCCS patients in Japan. We investigated the detailed clinical manifestations of 157 patients ranging in age from 9 months to 77 years old (mean: 33.1 years). We then compared the frequency and age of onset for various tumors developed in Japanese NBCCS patients with patients from the three countries listed above in which NBCCS studies were previously conducted. Our most significant finding was the low frequency of basal cell carcinoma (BCC) in Japane...

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma.

The British Journal of Dermatology — Fri, 13 Jan 2012 05:00:00 +0100

Conclusions: Reduction of Langerhans cells during clinical treatment of BCC might potentially impact negatively on anti-tumour responses through reduced activation of tumour-specific effector cells. Investigation of modified PDT protocols with the aim to minimise immunosuppressive effects whilst maintaining anti-tumour efficacy is warranted. PMID: 22242712 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Delayed Foreign Body Reaction to Steel Wire Suture Resembling Basal Cell Carcinoma.

Actas Dermo-Sifiliograficas — Fri, 13 Jan 2012 05:00:00 +0100

Authors: Neila J, Perea M, Ríos-Martín JJ, Camacho FM PMID: 22245465 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Basal Cell Carcinoma of the Nipple: An Uncommon but Ever-Increasing Location

Computational Intelligence and Neuroscience — Thu, 12 Jan 2012 11:11:41 +0100

We present an additional case of BCC located on the nipple, presenting with enlargement of the nipple as a sole clinical finding in a 60-year-old man. (Source: Computational Intelligence and Neuroscience)

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What is the cause of retraction spaces associated with basal cell carcinoma?

Journal of Cutaneous Pathology — Wed, 11 Jan 2012 05:00:00 +0100

(Source: Journal of Cutaneous Pathology)

Keratocystic Odontogenic Tumors and Carnoy’s Solution: Results and Complications Assessment

Oral Diseases — Tue, 10 Jan 2012 05:00:00 +0100

Conclusions: Complementary treatment with Carnoy’s solution and peripheral ostectomy appear to provide efficient treatment for keratocystic odontogenic tumors. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.© 2012 John Wiley & Sons A/S (Source: Oral Diseases)

Basal Cell Carcinoma

Consultant Live — Mon, 09 Jan 2012 06:30:02 +0100

The smooth and translucent nature of this nodule suggests the correct diagnosis: basal cell carcinoma. (Source: Consultant Live)

Multiple Cranial Neuropathies Evolving Over a Decade From Occult Perineural Basal Cell Carcinoma [Images in Neurology]

Archives of Neurology — Mon, 09 Jan 2012 05:00:00 +0100

(Source: Archives of Neurology)

Cathepsin K expression in basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology — Thu, 05 Jan 2012 05:00:00 +0100

Conclusion Cathepsin K expression may contribute to tumour invasion and peculiar histopathological features, such as fibromucinous stroma around the tumour nests by mediating extracellular matrix degradation in BCC. (Source: Journal of the European Academy of Dermatology and Venereology)

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Does hormone replacement therapy and use of oral contraceptives increase the risk of non-melanoma skin cancer?

Cancer Causes and Control — Wed, 04 Jan 2012 06:47:24 +0100

Conclusion The findings indicated that HRT but not OC may increase the risk of NMSC. However, further studies are warranted as risk estimates for SCC had relatively low precision due to a limited number of SCC cases. Content Type Journal ArticleCategory Original paperPages 1-10DOI 10.1007/s10552-011-9887-4Authors Fatima Birch-Johansen, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen O, DenmarkAllan Jensen, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen O, DenmarkAnne Braae Olesen, Department of Dermatology, Aarhus University Hospital, Aarhus Hospital, P.P. Ørumsgade 11, 8000 Aarhus C, DenmarkJane Christensen, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen O, DenmarkAnne Tjønnel...

Frequency of non‐histologically diagnosed basal cell carcinomas in daily Dutch practice

Journal of the European Academy of Dermatology and Venereology — Tue, 03 Jan 2012 05:00:00 +0100

Conclusions The total burden of BCC is underestimated by the absence of data on the occurrence of non‐histologically diagnosed BCCs in daily dermatological practice. It is pivotal for Dutch healthcare policy makers to acknowledge this to make accurate BCC‐related cost estimates. (Source: Journal of the European Academy of Dermatology and Venereology)

Market watch: Upcoming market catalysts in Q1 2012

Nature Reviews Drug Discovery — Tue, 03 Jan 2012 05:00:00 +0100

Nature Reviews Drug Discovery 11, 10 (2012). doi:10.1038/nrd3632 Author: Edny Inui Important catalysts for the first quarter of 2012 include approval decisions on vismodegib for the treatment of adults with advanced basal cell carcinoma (BCC), and on peginesatide for anaemia associated with chronic kidney disease (CKD). Top-line Phase III data are also expected for tivozanib for (Source: Nature Reviews Drug Discovery)

Intraosseous Fibrosarcoma of Maxilla in an HIV Patient.

Archives of Iranian Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Kotrashetti VS, Kale AD, Hallikeremath SR, Mane DR, V Angadi P, Bhatt P Abstract Fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. Fibrosarcomas account for 15% of all soft tissue sarcomas, which represent only 1% of all malignant tumors of the head and neck region. The clinical behavior of the fibrosarcoma is characterized by a high local recurrence rate, and low incidence of loco regional lymph node and/or distant hematogenous metastasis. The etiology for fibrosarcoma has no definite cause but is thought to occur from preexisting lesions or in previously irradiated areas of bone lesions. Immunosuppression associated with HIV infection and acquired immune deficiency syndrome (...

The malassezia genus in skin and systemic diseases.

Clinical Microbiology Reviews — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A Abstract Summary: In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. restricta, and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis, M. japonica, M. yamatoensis, M. nana, M. caprae, M. equina, and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species...

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Nevoid basal cell carcinoma syndrome in Indian patients: a clinical and radiological study of 6 cases and review of literature

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Combining the current series with 17 additional cases reported in Indian patients, it is evident that the frequency of clinical and radiological features in NBCCS in Indian patients differs from other ethnic groups. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Disfiguring basal cell carcinoma of the nose ("clown nose").

Ear, Nose and Throat Journal — Sun, 01 Jan 2012 05:00:00 +0100

Disfiguring basal cell carcinoma of the nose ("clown nose"). Ear Nose Throat J. 2012 Jan;91(1):E26-7 Authors: Aneiros-Fernandez J, Arias-Santiago S, Garcia-Lopez C, O'Valle F PMID: 22278876 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Giant basal cell carcinoma of the skin: literature review and personal experience

Journal of the European Academy of Dermatology and Venereology — Sat, 31 Dec 2011 06:08:29 +0100

AbstractAs the most common form of skin cancer, basal cell carcinoma (BCC) is typified by locally infiltrative growth and a very low risk of metastasis. On occasion, however, this otherwise indolent neoplasm may behave aggressively, demonstrating deep tissue invasion and a high rate of postsurgical recurrence. The pathogenesis and determinants of such tenacious growth are not completely understood. Only 1% of all BCC’s achieve the status of ‘giant’, as defined in 1988 by the American Joint Committee on Cancer. In this article, the authors provide a comprehensive review of the scientific literature on giant basal cell carcinoma (GBCC) of the skin and report their experience with this rare tumour subtype. (Source: Journal of the European Academy of Dermatology and Venereology)

Basal Cell Carcinoma in Childhood: A Case Report

Pediatric Dermatology — Fri, 30 Dec 2011 05:00:00 +0100

This article describes an otherwise typical basal cell carcinoma arising in young patient, with emphasis on histologic diagnosis. (Source: Pediatric Dermatology)

Pulmonary embolism and reactivation of tuberculosis during everolimus therapy in a kidney transplant recipient.

Annals of Transplantation — Fri, 30 Dec 2011 05:00:00 +0100

Conclusions: This case shows that kidney transplanted patients treated with everolimus presenting symptoms of pneumonia should also be screened for pulmonary embolism. Patients treated with PSIs may be prone to reactivation of tuberculosis. When tuberculosis treatment is started, much larger doses of everolimus are required.<br /> PMID: 22210429 [PubMed - in process] (Source: Annals of Transplantation)

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Rippled‐pattern basal cell carcinoma

The Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

AbstractBasal cell carcinoma (BCC) is the most common malignant cutaneous neoplasm, however, there have been few studies on BCC with a “rippled pattern” so far. We reviewed the 650 BCC specimens from the archives of our institution, and only one example of BCC with a rippled pattern was found. We herein report the histopathological characteristics of this case. Within the lesion, which showed the typical histopathological features of nodular BCC, there was a noticeable area composed of 10–15 basaloid aggregations, which showed the rippled pattern. The rippled pattern was characterized by alternating bands of epithelial cords of spindle‐shaped basaloid cells and mucinous spaces. Characteristically, around the rippled‐pattern area, neoplastic aggregations with a mucinous reticulate...

Skin Cancers of the Hand and Upper Extremity

The Journal of Hand Surgery — Thu, 29 Dec 2011 03:44:44 +0100

Skin cancers represent the most common primary malignancies of the hand. They typically present as painless lesions on areas of high sun exposure, such as the dorsum of the hand and upper extremity. The most common malignancy is squamous cell carcinoma, followed by basal cell carcinoma and melanoma. The key to successful treatment is early and accurate diagnosis and treatment. Unlike open biopsies, which are indicated for deep soft tissue and bone lesions, biopsies for skin cancer can be performed under local anesthesia in the office setting in the form of shave or punch biopsies. A number of nonsurgical treatment options are available for treatment. However, when surgical excision is indicated, appropriate margin resections are dictated by the grade and stage of the malignancy. (Source: T...

[Rhinophyma and skin carcinoma: A case report and literature review.]

Annales de Chirurgie Plastique et Esthetique — Wed, 28 Dec 2011 05:00:00 +0100

We present the case of a patient with basal cell carcinoma diagnosed on rhinophyma. The removal of all cutaneous nasal unit and its analysis has diagnosed the presence of three basal cell carcinomas and two in situ squamous cell carcinomas. Reconstruction was performed by full-thickness skin graft. The literature reports a few cases of association between rhinophyma and skin cancers but none ever reported the simultaneous presence of basal cell carcinoma and squamous cell carcinomas. The low number of articles does not reveal statistically significant relationship between rhinophyma and skin cancer, which would consider the rhinophyma as a risk factor. Monitoring of these patients should be as rigorous as possible and surgical care requires histologic analysis not to omit the presence of c...

Periocular Basal Cell Carcinoma: Nitrous Oxide Cryotherapy Periocular Basal Cell Carcinoma: Nitrous Oxide Cryotherapy

Medscape Today Headlines — Tue, 27 Dec 2011 04:00:00 +0100

Is nitrous oxide cryotherapy an established and trusted way to treat periocular basal cell carcinoma? The British Journal of Ophthalmology (Source: Medscape Today Headlines)

Retrospective study of 25 cases of keratocystic odontogenic tumor: epidemiology and treatment.

J Contemp Dent Pract — Sun, 25 Dec 2011 03:30:05 +0100

Conclusion: Our data analysis showed the importance of previous diagnosis before enucleation procedure and long-term follow-up for recurrence early detection. Recurrence incidence is more frequent on first year after diagnosis. Clinical significance: KOT is a benign tumor with local aggressive behavior and therefore its treatment must consider the high index of recidive. Reports of protocol treatment should raise new discussion to decrease recurrence rates. Keywords: Keratocyst, Odontogenic tumor, Keratocystic odontogenic tumor. How to cite this article: Schussel JL, Stramandinoli RT, Dissenha JL, Avila LFC, Sassi LM. Retrospective Study of 25 Cases of Keratocystic Odontogenic Tumor: Epidemiology and Treatment. J Contemp Dent Pract 2011;12(2):100-103. Source of support: Nil Conflict of int...

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The incidence of basal cell carcinoma in the under‐30s in the UK

Clinical And Experimental Dermatology — Fri, 23 Dec 2011 05:00:00 +0100

Conclusions. The reported incidence of BCC in those aged < 30 years has increased by 145% during this period, corresponding to an average annual increase of 8.53%. This may be partially due to earlier presentation and to increased use of surgical treatments. (Source: Clinical And Experimental Dermatology)

Licensing application submitted in EU for vismodegib in advanced basal cell carcinoma

NeLM - News — Fri, 23 Dec 2011 05:00:00 +0100

Source: BioSpace Area: News A Marketing Authorization Application for vismodegib has been submitted to the European Medicines Agency for the treatment of adults with advanced basal cell carcinoma, for whom surgery is considered inappropriate. Vismodegib is a first-in-class, investigational, oral medicine designed to selectively inhibit signalling in the Hedgehog pathway and is being developed by Roche and Genentech. The application is based on clinical data from a phase II study (ERIVANCE BCC/SHH4476g). (Source: NeLM - News)

The relationship between basal and squamous cell skin cancer and smoking related cancers

BMC Research Notes — Thu, 22 Dec 2011 05:00:00 +0100

Conclusions: Individuals with a history of SCC having an increased risk of developing smoking related cancers cancer suggests smoking as a common etiology. The relationship between BCC and smoking-related cancers is less certain. (Source: BMC Research Notes)

Tanning beds raise basal cell risk, too

Modern Medicine — Wed, 21 Dec 2011 05:00:00 +0100

New research suggests that the use of tanning beds, already linked to increased risk of melanoma in users, also increases the odds of developing basal cell carcinoma for young people, Reuters reports. (Source: Modern Medicine)

Vitamin D and Nonmelanoma Skin Cancer in a Health Maintenance Organization Cohort [Study]

Archives of Dermatology — Mon, 19 Dec 2011 05:00:00 +0100

Conclusions An increased baseline serum 25-OHD level was significantly associated with an increased NMSC risk. This association was positive, though nonsignificant on less UV-exposed body sites, and UV exposure remains a likely confounder. The complex and confounded relationship of vitamin D, UV, and NMSC makes classic epidemiological investigation difficult in the absence of carefully measured history of cumulative UV exposure. (Source: Archives of Dermatology)

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Smoking Raises Risk Of Squamous Cell Carcinoma Of The Skin In Women

Health News from Medical News Today — Sat, 17 Dec 2011 18:00:00 +0100

Regular female smokers have a threefold higher risk of developing squamous cell carcinoma of the skin, researchers from Moffitt Cancer Center reported in Cancer Causes and Control. The authors said they found a slight increase in risk among regular male smokers, but a statistically insignificant one. Dana E. Rollison and team recruited 380 patients with skin cancer and 315 controls (healthy patients with no current or past skins cancers) for their study. 215 had confirmed basal cell carcinoma and 165 had squamous cell carcinoma (both types of skin cancers)... (Source: Health News from Medical News Today)

Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer

EURASIP Journal on Bioinformatics and Systems Biology — Sat, 17 Dec 2011 15:37:59 +0100

Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of the ubiquitin system has been linked to many diseases including skin cancer. The ubiquitin pathways activated among skin cancers are highly diverse and may reflect the various characteristics of the cancer type. Basal cell carcinoma and squamous cell carcinoma, the most common types of human skin cancer, are instances where the involvement of the deubiquitination enzyme CYLD has been recently highlighted. In basal cell carcinoma, the tumor suppressor protein CYLD is repressed at the transcriptional levels through hedgehog signaling pathway. Downregulatio...

Morpheaform facial basal cell carcinoma – a 16‐year experience in an Asian center

International Journal of Dermatology — Fri, 16 Dec 2011 05:00:00 +0100

(Source: International Journal of Dermatology)

Basal cell carcinoma of the scrotum with a lesion of 51 years’ duration

International Journal of Dermatology — Fri, 16 Dec 2011 05:00:00 +0100

(Source: International Journal of Dermatology)

Study: Smoking Linked to Skin Cancer in Women

About.com Cancer — Fri, 16 Dec 2011 05:00:00 +0100

If you are thinking about quitting smoking, here's another reason to kick the habit: skin cancer. Researchers have found an association between female smokers and basal cell carcinoma development, a type of skin cancer. The study found that women who have smoked for over 20 years double their risk of developing the non-fatal skin cancer. Men, however, also suffered an increased risk, but not as high of a rate as women. The study appears in the journal Cancer Causes Control....Read Full Post (Source: About.com Cancer)

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Photodynamic Therapy vs Imiquimod.

Actas Dermo-Sifiliograficas — Fri, 16 Dec 2011 05:00:00 +0100

Authors: Serra-Guillén C, Nagore E, Guillén C Abstract Photodynamic therapy and imiquimod are highly regarded treatments dermatologists frequently prescribe for actinic keratoses, basal cell carcinoma, and Bowen disease. The scarcity of evidence from comparative trials prevents us from drawing well-founded conclusions about the efficacy, tolerance, and adverse effects of these therapeutic options or to recommend one over the other in any particular type of lesion or patient. On the other hand, in certain conditions (eg, actinic chelitis, immunosuppression, and basal cell carcinoma affecting the eyelids), there is evidence to support the use of photodynamic therapy or imiquimod even though they might initially seem contraindicated. We critically review and compare the use of these...

Indoor Tanning Tied to Basal Cell Carcinoma: StudyIndoor Tanning Tied to Basal Cell Carcinoma: Study

Medscape Medical News Headlines — Wed, 14 Dec 2011 23:01:12 +0100

Tanning beds have already been linked to an increased risk of melanoma, and new research shows they can also raise the odds of basal cell carcinoma. Reuters Health Information (Source: Medscape Medical News Headlines)

Indoor Tanning Strong Risk Factor For Skin Cancer In Young People

Health News from Medical News Today — Wed, 14 Dec 2011 14:00:00 +0100

Compared to those who have never used it, young people who use indoor tanning have a 69% higher risk of developing a type of skin cancer called basal cell carcinoma (BCC), according to a new study led by researchers from the Yale School of Public Health in the US that was published online on 12 December in the Journal of the American Academy of Dermatology. The researchers found the risk was strongest among women and went up with every year of using indoor tanning. A number of studies published recently shows an increase in people, particularly young women, with BCC... (Source: Health News from Medical News Today)

Indoor tanning tied to common skin cancer: Report

Health News: CBSNews.com — Tue, 13 Dec 2011 21:28:44 +0100

Previous research tied tanning to deadly melanoma, new study found increased risk for more common basal cell carcinoma (Source: Health News: CBSNews.com)

Usefulness of margin detection by digital dermoscopy in the traditional surgical excision of basal cell carcinomas of the head and neck including infiltrative/morpheaform type

The Journal of Dermatology — Tue, 13 Dec 2011 05:00:00 +0100

AbstractIncomplete or suboptimal surgical excision of basal cell carcinoma of the head and neck is a relatively frequent occurrence. Methods of preoperative assessment of tumoral margins are therefore of paramount importance. The aim of this study was to compare the preoperative evaluation of margins with digital dermoscopy and clinical definition. One hundred and 12 patients with histologically confirmed basal cell carcinoma were selected for surgical excision. Subsequently, the margin of excision was determined by either clinical (45 patients) or dermoscopic evaluation (67 patients). After pre‐surgical clinical evaluation, 22% of histological specimens of excised basal cell carcinoma showed suboptimal margins of excision. Pre‐surgical dermoscopic evaluation had only 7% suboptimal exc...

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Search for Clastogenic Factors in the Plasma of Locally Irradiated Individuals.

Radiation Research — Tue, 13 Dec 2011 05:00:00 +0100

Authors: Lindholm C, Acheva A, Koivistoinen A, Perälä M, Heinävaara S, Jahns J, Salomaa S, Hildebrandt G Abstract In studies reported in the 1960s and in several investigations since, plasma from irradiated individuals was shown to induce chromosomal aberrations when transferred into normal blood cultures. In the present study, the aim was to investigate the occurrence of these clastogenic factors (CF) using markers representing DNA damage produced in reporter lymphocytes that are treated with plasma from locally exposed individuals. Blood plasma was obtained from clinical patients with benign conditions before and after they had received radiation to small treatment volumes. Three patient groups were studied: (I) marginal resected basal cell carcinoma, (II) painful osteoarthrit...

Researchers Find Smoking Is Strongly Associated With Squamous Cell Carcinoma Among Women

Health News from Medical News Today — Fri, 09 Dec 2011 10:00:00 +0100

Women who have non-melanoma skin cancers are more likely to have smoked cigarettes compared to women without skin cancer, said researchers at Moffitt Cancer Center in Tampa, Fla., who published study results in a recent issue of Cancer Causes Control. The study investigated the relationship between cigarette smoking and non-melanoma skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinomas (SCC)... (Source: Health News from Medical News Today)

Pigmented Lesion in the inguinal region.

Dermatol Online J — Wed, 07 Dec 2011 17:30:03 +0100

We report the case of a 60-year-old woman who presented with a 6-month history of a gradually enlarging solitary dark brown plaque in her right inguinal region. Histopathology showed hyperkeratosis with parakeratosis, acanthosis, disorganization of epidermal architecture, atypical keratinocytes, and increased melanin pigment of the papillary dermis. Considering the clinical and the histological evidence, a diagnosis of PBD was established. Complete resection confirmed the diagnosis. Pigmented Bowen disease is an unusual form of squamous carcinoma in situ. Other tumors in the differential diagnosis include pigmented basal cell carcinoma and superficial spreading melanoma. PMID: 22136868 [PubMed - in process] (Source: Dermatol Online J)

Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. −765G>C PTGS2 polymorphism and NMSC risk

Archives of Dermatological Research — Wed, 07 Dec 2011 12:54:48 +0100

The objectives of this study are: evaluation of the association between PTGS2 −765G>C polymorphism and the occurrence of non-melanoma skin cancer, the relationship between this polymorphism and cyclooxygenase-2 activity in skin tissue, as well as the correlation with serum CRP levels in patients with non-melanoma skin cancer. We used PCR–RFLP technique to explore −765G>C PTGS2 gene polymorphism, colorimetric analysis for cyclooxygenase-2 activity in skin tissue and immunoturbidimetric assay for CRP serum levels in 174 patients with non-melanoma skin cancer [54 patients with basal cell carcinoma (BCC) and 120 patients with squamous cell carcinoma (SCC)] and 80 healthy subjects. PTGS2 −765G>C polymorphism failed to show an association with non-melanoma skin cancer risk...

Automatic telangiectasia analysis in dermoscopy images using adaptive critic design

Skin Research and Technology — Mon, 05 Dec 2011 05:00:00 +0100

ConclusionWe have chosen BCC detection rather than vessel detection as the endpoint. Although vessel detection is inherently easier, BCC detection has potential direct clinical applications. Small BCCs are detectable early by dermoscopy and potentially detectable by the automated methods described in this research. (Source: Skin Research and Technology)

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Coffee consumption linked to lower risk for basal cell carcinoma

HemOncToday.com — Sun, 04 Dec 2011 01:59:17 +0100

(Source: HemOncToday.com)

Results of carbon ion radiotherapy for skin carcinomas in 45 patients

British Journal of Dermatology — Fri, 02 Dec 2011 05:00:00 +0100

Conclusions: The results demonstrated that heavy ion radiotherapy offers high local tumor control and progression‐free survival rates without significant radiation‐induced toxicity for patients with skin carcinomas. (Source: British Journal of Dermatology)

Results of carbon ion radiotherapy for skin carcinomas in 45 patients.

The British Journal of Dermatology — Fri, 02 Dec 2011 05:00:00 +0100

Conclusions: The results demonstrated that heavy ion radiotherapy offers high local tumor control and progression-free survival rates without significant radiation-induced toxicity for patients with skin carcinomas. PMID: 22136631 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Confounding factors may explain increasing skin cancer rates

Modern Medicine — Thu, 01 Dec 2011 05:00:00 +0100

Data suggest that proper sunscreen use can prevent melanoma and squamous cell carcinoma (SCC) and perhaps basal cell carcinoma (BCC), says Allan C. Halpern, M.D. However, he adds, confounding factors may explain the rising U.S. incidence rates of all skin cancers. (Source: Modern Medicine)

Skin Cancer Following Kidney Transplantation: A Single-Center Experience

Transplantation Proceedings — Thu, 01 Dec 2011 05:00:00 +0100

Abstract: One of the major problems associated with prolonged immunosuppression is a high occurrence of skin malignancies among kidney recipients. Studies have shown that nonmelanoma skin cancer is the most frequently occurring tumor after organ transplantation. The aim of this study was to determine the incidence of and identify possible risk factors for skin malignancies among a population of kidney recipients. This retrospective, single-center cohort comprised 1672 patients transplanted from 1994 to 2011. Only patients with a confirmed diagnosis of skin cancer were selected for medical records review. Among 836 kidney transplant recipients remaining under our care since 1994, skin malignancies were diagnosed in 16 patients (1.9%). The histological diagnoses included squamous cell carci...

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Primary orbital extraskeletal osteosarcoma.

Orbit — Thu, 01 Dec 2011 05:00:00 +0100

In this report, we describe the clinical, radiologic, and pathologic records of a rare case of primary ESOS of the orbit. PMID: 22132847 [PubMed - in process] (Source: Orbit)

[What's new in dermato-oncology?].

Annales de Dermatologie et de Cenereologie — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Basset-Séguin N Abstract One of the major advance concerning skin carcinoma is the development of targeted therapy: anti-patch/sonic/hedgehog for basal cell carcinoma (BCC) and anti-EGFR for squamous cell carcinoma (SCC). These therapies are indicated for advanced non surgically removable tumors. Their anti-tumoral efficacy has been shown, their effect seems to be suspensive which raises the question of their tolerability for long term use. Laboratory work have shown that BCC and SCC stem cells locate in different cell compartments and follow distinct molecular events which explains their distinct behaviour. The role of HPV in EBDR skin cancers has been ruled out. Photodynamic therapy induced-immunosuppression can be prevented by lowering the light fluence. The gene respo...

Increased immunoreactivity of membrane type‐1 matrix metalloproteinase (MT1‐MMP) and β‐catenin in high‐risk basal cell carcinoma

British Journal of Dermatology — Fri, 25 Nov 2011 05:45:29 +0100

Conclusions The results of this study suggest that MT1‐MMP might be a novel marker for high‐risk BCC. In addition, expression of both β‐catenin and MT1‐MMP was increased in high‐risk BCC tumour cells, indicating that these two proteins may play an important role in locally invasive and highly destructive growth behaviour of high‐risk BCCs. (Source: British Journal of Dermatology)

Relationship between food intake and cutaneous solar elastosis adjacent to basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology — Thu, 24 Nov 2011 05:00:00 +0100

Conclusion Our study provides evidence that the presence of dermal elastosis and cutaneous ageing may be influenced by the type of food intake: Vitamin E and C‐rich fruit and tea are positively associated with less elastosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Aesthetic evaluation after non‐invasive treatment for superficial basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology — Mon, 21 Nov 2011 05:00:00 +0100

Conclusion The use of the 4‐point scale is a valid method to compare scars of non‐invasive dermatological treatments. Supplementary registering vascularity and pigmentation can be useful in future studies. (Source: Journal of the European Academy of Dermatology and Venereology)

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Efficacy of Curettage-Electrodesiccation for Basal Cell Carcinoma in Medium- and High-Risk Areas.

Actas Dermo-Sifiliograficas — Mon, 21 Nov 2011 05:00:00 +0100

Authors: Rodríguez-Vigil T, Vázquez-López F, Pérez-Oliva N PMID: 22113120 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Basal cell carcinoma masquerading as habit tic

Clinical And Experimental Dermatology — Sat, 19 Nov 2011 22:24:54 +0100

(Source: Clinical And Experimental Dermatology)

Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin

Carcinogenesis — Fri, 18 Nov 2011 05:00:00 +0100

In conclusion, we found that two polymorphisms in inflammatory genes interacting with environmental risk factors could modulate BCC risk. (Source: Carcinogenesis)

Facial and Nasal Cancer Reconstruction Case StudyFacial and Nasal Cancer Reconstruction Case Study

Medscape Today Headlines — Thu, 17 Nov 2011 18:40:00 +0100

A 3-stage surgical procedure illustrates the most important principles of facial and nasal reconstruction in patients with basal cell carcinoma. Medscape Plastic Surgery (Source: Medscape Today Headlines)

Effects of ultraviolet radiation exposure on FOXP3+ infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma

Photodermatology, Photoimmunology and Photomedicine — Thu, 17 Nov 2011 10:59:35 +0100

ConclusionsThis study shed some light on the effect of UVR on FOXP3+ infiltration in skin (pre)malignant carcinomas. Our data suggested that FOXP3+ infiltration was positively related to UVR exposure. The mechanisms merit further investigation. (Source: Photodermatology, Photoimmunology and Photomedicine)

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Pre-Treatment Deep Curettage Can Significantly Reduce Tumour Thickness in Thick Basal Cell Carcinoma While Maintaining a Favourable Cosmetic Outcome When Used in Combination with Topical Photodynamic Therapy

Clinical and Developmental Immunology — Wed, 16 Nov 2011 12:13:12 +0100

In conclusion, deep curettage significantly reduces BCC thickness and may with topical PDT provide a favourable clinical and cosmetic short-term outcome. (Source: Clinical and Developmental Immunology)

Highlights from this issue

British Journal of Ophthalmology — Wed, 16 Nov 2011 05:00:00 +0100

Cryotherapy for periocular basal cell carcinoma Moesen et al report the 5-year outcome of 100 patients with primary periocular basal cell carcinoma treated by cryotherapy (double freeze-thaw cycle). In this prospective, non-comparative, interventional case series, only circumscribed tumours with maximum diameter of 8 mm were included. Histologically proven recurrence rate was 8%. There was no correlation between tumour site, tumour size, cryotherapy freeze time and recurrence. (see page 1679) RNFL and macular thickness in amblyopia Al-Haddad et al studied peripapillary retinal nerve fibre layer (RNFL) and macular thickness in unilateral amblyopia (strabismic or anisometropic) and non-amblyopic anisometropia. SD-OCT measurements were compared with fellow eyes. The mean age was 20 ...

Nitrous oxide cryotherapy for primary periocular basal cell carcinoma: outcome at 5 years follow-up

British Journal of Ophthalmology — Wed, 16 Nov 2011 05:00:00 +0100

Conclusion The results of this series suggest that nitrous oxide probe cryotherapy for primary periocular basal cell carcinomas up to 8 mm diameter has a recurrence rate of ~8%. Cryotherapy has certain advantages over surgical removal of tumours of this size in the periocular region, but careful follow-up is advisable. (Source: British Journal of Ophthalmology)

The ophthalmic side-effects of imiquimod therapy in the management of periocular skin lesions

British Journal of Ophthalmology — Wed, 16 Nov 2011 05:00:00 +0100

Conclusion Conjunctivitis and ocular stinging were the commonest ophthalmic side-effects encountered with the application of imiquimod for periocular skin lesions. These effects were temporary and resolved on terminating the imiquimod therapy. (Source: British Journal of Ophthalmology)

Human Papillomaviruses, 16INK4a and Akt expression in basal cell carcinoma

Journal of Experimental and Clinical Cancer Research — Mon, 14 Nov 2011 05:00:00 +0100

Conclusions: Our data show that p16INK4a and pAkt are over-expressed in BCC and that the high expression of p16INK4a and of Akt2 isoform is often associated with the presence of beta-HPV species 2 (i.e. HPV 15). The association of these viruses with the up-regulation of p16INK4a and Akt/PI3K pathway suggests that in a subtype of BCC these viruses may exert a role in the carcinogenesis or in other, still undefined, biological property of these tumors. If this particular type of BCC reflects a different biology it will remain undisclosed until further studies on a larger number of samples will be performed. (Source: Journal of Experimental and Clinical Cancer Research)

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Teaching NeuroImages: Perineural spread of basal cell carcinoma along the trigeminal nerve

Neurology — Mon, 14 Nov 2011 05:00:00 +0100

(Source: Neurology)

Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells.

Toxicology and Applied Pharmacology — Sun, 13 Nov 2011 05:00:00 +0100

This study demonstrates that arecoline has potential for preventing BCC tumorigenesis by reducing levels of the tumor cell survival factor IL-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis. PMID: 22108589 [PubMed - as supplied by publisher] (Source: Toxicology and Applied Pharmacology)

Shark island pedicle flap for repairing of basal cell carcinoma localized in nasal ala-perialar region: a simple procedure

Anais Brasileiros de Dermatologia — Thu, 10 Nov 2011 07:13:02 +0100

We describe a single-staged technique for correction of nasal ala defect after the excision of a basal cell carcinoma. This technique allows correction of surgical defects of the ala rebuilding the original anatomy, maintaining cosmetic units, without need for a graft (Source: Anais Brasileiros de Dermatologia)

Risk Factors for Basal Cell Carcinoma: A Study From the National Dermatology Center of Colombia.

Actas Dermo-Sifiliograficas — Thu, 10 Nov 2011 05:00:00 +0100

CONCLUSIONS: Different factors specific to Colombia increase the risk of basal cell carcinoma. In particular, the association with phototype III could partly explain the increase in incidence detected in this country. Preventive programs should target the risk groups detected and highlight the importance of basing decisions on local evidence. PMID: 22078143 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

FDA Accepts Genentech's New Drug Application For Vismodegib In Advanced Form Of Skin Cancer

Pharmaceutical Online News — Wed, 09 Nov 2011 06:00:00 +0100

Genentech, a member of the Roche Group, recently announced that the U.S. Food and Drug Administration (FDA) has accepted and filed the company's New Drug Application for vismodegib for the treatment of adults with advanced basal cell carcinoma (BCC) for whom surgery is considered inappropriate. (Source: Pharmaceutical Online News)

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FDA accepts Roche's New Drug Application for vismodegib in advanced form of skin cancer

Roche Media News — Wed, 09 Nov 2011 06:00:00 +0100

Roche today announced that the U.S. Food and Drug Administration (FDA) has accepted and filed the company’s New Drug Application for vismodegib for the treatment of adults with advanced basal cell carcinoma (BCC) for whom surgery is considered inappropriate. The application has been granted Priority Review status and the FDA confirmed the action date is March 8, 2012. (Source: Roche Media News)

Nevoid basal cell carcinoma syndrome.

Dermatol Online J — Wed, 02 Nov 2011 03:40:04 +0100

We present a patient with many classic features and review some of the treatment options available for these patients. PMID: 22031649 [PubMed - in process] (Source: Dermatol Online J)

Pitfalls of Using Dermatoscopy in Defining Surgical Margins of Basal Cell Carcinoma

Dermatologic Surgery — Tue, 01 Nov 2011 04:00:00 +0100

(Source: Dermatologic Surgery)

Bag-of-Features Based Medical Image Retrieval via Multiple Assignment and Visual Words Weighting

IEE Transactions on Medical Imaging — Tue, 01 Nov 2011 04:00:00 +0100

Bag-of-features based approaches have become prominent for image retrieval and image classification tasks in the past decade. Such methods represent an image as a collection of local features, such as image patches and key points with scale invariant feature transform (SIFT) descriptors. To improve the bag-of-features methods, we first model the assignments of local descriptors as contribution functions, and then propose a novel multiple assignment strategy. Assuming the local features can be reconstructed by their neighboring visual words in a vocabulary, reconstruction weights can be solved by quadratic programming. The weights are then used to build contribution functions, resulting in a novel assignment method, called quadratic programming (QP) assignment. We further propose a novel vi...

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Ultraviolet‐Fluorescent Tattoo Location of Cutaneous Biopsy Site

Dermatologic Surgery — Tue, 01 Nov 2011 04:00:00 +0100

ConclusionThe present study documents the utility of an UV‐fluorescent tattoo to locate a biopsy site. (Source: Dermatologic Surgery)

Two-stage treatment protocol of keratocystic odontogenic tumour in young patients with Gorlin–Goltz syndrome: Marsupialization and later enucleation with peripheral ostectomy. A 5-year-follow-up experience

International Journal of Pediatric Otorhinolaryngology — Tue, 01 Nov 2011 01:32:15 +0100

Conclusions: The main advantage of this modality is the preservation of important anatomical structures involved in the lesion and jaw's continuity. Therefore in a selected group of cooperative patients, especially those affected of Gorlin–Goltz syndrome, the surgical protocol exposed allows for a less invasive approach with excellent results avoiding extensive disfiguring procedures. (Source: International Journal of Pediatric Otorhinolaryngology)

White shiny structures: dermoscopic features revealed under polarized light

Journal of the European Academy of Dermatology and Venereology — Mon, 31 Oct 2011 04:00:00 +0100

Conclusion The presence of white shiny lines of any length accompanied by white shiny areas is most suggestive of a diagnosis of BCC (P < 0.001). Melanomas are more likely to display short white shiny lines in an orthogonal distribution (P < 0.001) and without white shiny areas. Actinic tumours are most likely to exhibit rosettes (P < 0.001). (Source: Journal of the European Academy of Dermatology and Venereology)

Coffee consumption could reduce risk for basal cell carcinoma

MedWire News - Dermatology — Mon, 31 Oct 2011 03:56:13 +0100

Drinking more than three cups of coffee a day could significantly reduce a person’s risk for basal cell carcinoma, suggest study findings. (Source: MedWire News - Dermatology)

Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence

Cancer and Metastasis Reviews — Sun, 30 Oct 2011 05:37:42 +0100

Abstract Cyclooxygenase (COX)-derived prostaglandins (PGs) exhibit manifold functions in acute and chronic skin inflammation induced by a number of physical (ultraviolet (UV) light, wounding) and chemical (12-O-tetradecanoylphorbol 13-acetate (TPA), arachidonic acid) noxious stimuli. Depending on the challenge and the context, constitutively expressed COX-1 or the transiently induced COX-2 isoform are of relevance. Moreover, squamous cell carcinoma (SCC) of skin is a prominent example of epithelial neoplasia that consistently overexpresses COX-2 in the parenchyme and the mesenchyme of premalignant and malignant lesions, while COX-1 expression remains unaltered. Pharmacological, clinical, and experimental animal studies as well as a few epidemiological studies document the ...

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Pleomorphic basal cell carcinoma of the eyelid with true ductular differentiation

Graefe's Archive for Clinical and Experimental Ophthalmology — Fri, 28 Oct 2011 17:17:36 +0100

Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s00417-011-1836-0Authors Frederick A. Jakobiec, David G. Cogan Laboratory of Ophthalmic Pathology, Boston, MA, USAFouad R. Zakka, David G. Cogan Laboratory of Ophthalmic Pathology, Boston, MA, USADaniel J. Townsend, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA Journal Graefe's Archive for Clinical and Experimental OphthalmologyOnline ISSN 1435-702XPrint ISSN 0721-832X (Source: Graefe's Archive for Clinical and Experimental Ophthalmology)

Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis.

Mini Reviews in Medicinal Chemistry — Fri, 28 Oct 2011 04:00:00 +0100

Authors: Afaq F, Katiyar SK Abstract Polyphenols are a large family of naturally occurring plant products and are widely distributed in plant foods, such as, fruits, vegetables, nuts, flowers, bark and seeds, etc. These polyphenols contribute to the beneficial health effects of dietary products. Clinical and epidemiological studies suggest that exposure of the skin to environmental factors/pollutants, such as solar ultraviolet (UV) radiation induce harmful effects and leads to various skin diseases including the risk of melanoma and non-melanoma skin cancers. The incidence of non-melanoma skin cancer, comprising of squamous cell carcinoma and basal cell carcinoma, is a significant public health concern world-wide. Exposure of the skin to solar UV radiation results in inflammation, ...

Coffee consumption could reduce risk for basal cell carcinoma

MedWire News - Oncology — Fri, 28 Oct 2011 00:00:00 +0100

Drinking more than three cups of coffee a day could significantly reduce a person’s risk for basal cell carcinoma, suggest study findings. (Source: MedWire News - Oncology)

Basal cell carcinoma: Drinking coffee lowers risk of common skin cancer - especially in women

the Mail online | Health — Thu, 27 Oct 2011 01:44:23 +0100

Scientists from Harvard found that women who drank three or more cups of coffee a day had a 20 per cent lower risk of developing basal cell carcinoma compared to those who had less than a cup per month. (Source: the Mail online | Health)

Plantar basal cell carcinoma in a patient with xeroderma pigmentosum: importance of dermoscopy for early diagnosis of nonpigmented skin cancer

British Journal of Dermatology — Wed, 26 Oct 2011 11:32:42 +0100

(Source: British Journal of Dermatology)

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Daily coffee may lower your skin cancer risk

USATODAY.com Health — Tue, 25 Oct 2011 15:29:46 +0100

Basal cell carcinoma is the most common form of skin cancer. A diet that contains even a small protective factor may have great impact. (Source: USATODAY.com Health)

Coffee Drinking Linked To Lower Risk Of Common Skin Cancer

Health News from Medical News Today — Tue, 25 Oct 2011 14:00:00 +0100

New research presented at a conference in the US on Monday finds that drinking coffee is linked to a lower risk of a common form of skin cancer known as basal cell carcinoma (BCC). Results of a prospective study that followed over 25,000 cases of skin cancer suggest coffee may be an important dietary option to prevent BCC. The research is the work of Dr Fengju Song and colleagues. Song is a postdoctoral fellow in the department of dermatology at Brigham and Women's Hospital and Harvard Medical School... (Source: Health News from Medical News Today)

Coffee Consumption Associated With Decreased Risk For Basal Cell Carcinoma

Health News from Medical News Today — Tue, 25 Oct 2011 07:00:00 +0100

Caffeine could be related to an inverse association between basal cell carcinoma risk and consumption of coffee, a study found. The prospective study, presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011, examined the risks of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma in connection with coffee consumption and found a decreased risk for BCC only... (Source: Health News from Medical News Today)

Increased Tanning Bed Use Increases Risk For Deadly Skin Cancers

Health News from Medical News Today — Tue, 25 Oct 2011 07:00:00 +0100

Researchers confirmed an association between tanning bed use and an increased risk for three common skin cancers basal cell carcinoma, squamous cell carcinoma and melanoma, according to results presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011. The popularity of indoor tanning is widespread, with roughly 10 percent of Americans using a tanning facility each year. However, use of tanning beds has been shown to be associated with an increased risk for skin cancer, according to lead researcher Mingfeng Zhang, M.D... (Source: Health News from Medical News Today)

Coffee Lowers Risk Of Skin Cancer Basal Cell Carcinoma

Health News from Medical News Today — Tue, 25 Oct 2011 02:00:00 +0100

A prospective study found that the more coffee an adult drinks, the lower their risk seems to be for developing basal cell carcinoma, a common type of skin cancer. Researchers from Brigham and Women's Hospital and Harvard Medical School presented their findings at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, explaining that there is an inverse association between coffee consumption and basal cell carcinoma risk. Basal cell carcinoma, also known as BCC is the most common form of skin cancer... (Source: Health News from Medical News Today)

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Daily Coffee May Lower Your Skin Cancer Risk

The Doctors Lounge - Oncology — Mon, 24 Oct 2011 22:00:00 +0100

Researchers find association between caffeine consumption, basal cell carcinoma (Source: The Doctors Lounge - Oncology)

Increased tanning bed use increases risk for deadly skin cancers

EurekAlert! - Cancer — Mon, 24 Oct 2011 04:00:00 +0100

(American Association for Cancer Research) Researchers confirmed an association between tanning bed use and an increased risk for three common skin cancers -- basal cell carcinoma, squamous cell carcinoma and melanoma, according to results presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011. (Source: EurekAlert! - Cancer)

Daily Coffee May Lower Your Skin Cancer Risk

Cancercompass News: Other Cancer — Mon, 24 Oct 2011 00:00:00 +0100

Researchers find association between caffeine consumption, basal cell carcinoma (Source: Cancercompass News: Other Cancer)

Iatrogenic immunosuppression and cutaneous malignancy

Clinics in Dermatology — Sat, 22 Oct 2011 04:59:17 +0100

Abstract: Patients with autoimmune and inflammatory conditions often receive long-term immunosuppressive therapy. Some of the largest patient populations with iatrogenic immunosuppression include patients who have received solid-organ transplants or who have rheumatoid arthritis or psoriasis. Although treatments improve patient outcomes, individuals with immunosuppression subsequently may have an increased risk of skin cancer, including squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. (Source: Clinics in Dermatology)

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Variable expression of naevoid basal cell carcinoma syndrome in a family with a novel mutation in the PTCH1 gene

Clinical And Experimental Dermatology — Tue, 18 Oct 2011 04:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma

Human Genetics — Mon, 17 Oct 2011 16:04:10 +0100

Abstract Genome-wide association studies (GWASs) have primarily focused on marginal effects for individual markers and have incorporated external functional information only after identifying robust statistical associations. We applied a new approach combining the genetics of gene expression and functional classification of genes to the GWAS of basal cell carcinoma (BCC) to identify potential biological pathways associated with BCC. We first identified 322,324 expression-associated single-nucleotide polymorphisms (eSNPs) from two existing GWASs of global gene expression in lymphoblastoid cell lines (n = 955), and evaluated the association of these functionally annotated SNPs with BCC among 2,045 BCC cases and 6,013 controls in Caucasians. We then grouped them into...

Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology.

Acta Dermato-Venereologica — Mon, 17 Oct 2011 04:00:00 +0100

Authors: Hinz T, Ehler LK, Hornung T, Voth H, Fortmeier I, Maier T, Höller T, Schmid-Wendtner MH Abstract Optical coherence tomography (OCT) is a new imaging method with promising results for several dermatological indications, including preoperative skin tumour characterization. While high-frequency ultrasound (HFUS) is frequently used for this purpose, overestimation of tumour thickness is a problem, due to subtumoral inflammatory infiltration that cannot be differentiated from tumour tissue. The aim of this single-centre study was to describe OCT features of basal cell carcinoma (BCC) and to determine vertical tumour thickness accurately, including a comparison with HFUS and histopathology. Tumour thickness values of 10 BCCs measured by OCT did not differ significantly from tho...

Regulatory watch: Leading Hedgehog inhibitor submitted for approval as skin cancer drug

Nature Reviews Drug Discovery — Fri, 14 Oct 2011 04:00:00 +0100

Nature Reviews Drug Discovery 10, 802 (2011). doi:10.1038/nrd3594 Genentech has filed a new drug application with the US Food and Drug Administration for vismodegib, a Hedgehog (HH) pathway inhibitor that has shown promising results in a Phase II trial in patients with advanced basal cell carcinoma (BCC).The results of the trial, which (Source: Nature Reviews Drug Discovery)

Basal cell carcinoma and anthropometric factors in the U.S. radiologic technologists cohort study

International Journal of Cancer — Wed, 12 Oct 2011 00:42:53 +0100

AbstractBasal cell carcinoma (BCC) is the most common cancer in Caucasian populations. Although several risk factors are well‐established, including ultraviolet radiation (UVR) sensitivity and exposure, few studies have examined anthropometric measures and BCC. Using Cox proportional hazards regression analysis, we prospectively investigated the relationship between height, weight, and body mass index (BMI) and BCC in 58,213 Caucasian participants (11,631 men and 46,582 women) from the United States Radiological Technologists cohort. This analysis was limited to participants who were cancer‐free at baseline. The baseline questionnaire provided self‐reported anthropometric factors and the subsequent questionnaire collected skin cancer susceptibility factors, lifetime UVR exposure deri...

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Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Head and Neck Pathology — Mon, 10 Oct 2011 15:05:15 +0100

Abstract Xeroderma pigmentosum (XP) is a rare autosomal recessive defect in DNA endonuclease activity that is associated with the development of cutaneous malignancies, at sun exposed sites, including basal cell carcinoma, squamous cell carcinoma, and melanoma. Squamous cell carcinomas are also known to target the anterior tongue. Patients sometimes develop angiosarcomas, and these invariably arise from sun-exposed skin. A biopsy was taken from a large mass arising in the anterior tongue of an 11-year-old girl with XP and a history of cutaneous basal cell carcinomas. The histopathologic findings demonstrated a high grade epithelioid neoplasm resembling a poorly differentiated squamous cell carcinoma, but the immunohistochemical profile (AE1/AE3 negative, p63 negative, CD31...

Risk Factors for Orbital Exenteration in Periocular Basal Cell Carcinoma

American Journal of Ophthalmology — Fri, 07 Oct 2011 04:00:00 +0100

Conclusions: The need for exenteration for BCC may be significantly higher when the lesion involves a medial canthal location, initial management does not include margin-controlled excision, or pathologic analysis reveals an infiltrative subtype. Margin-controlled excision for periocular BCC and close follow-up after excision for medial canthal BCC may be indicated. (Source: American Journal of Ophthalmology)

Audit of incomplete excisions and recurrences in surgically treated basal cell carcinoma and squamous cell carcinoma among head and neck skin cancer patients in Basingstoke and north Hampshire hospital

International Journal of Surgery — Thu, 06 Oct 2011 22:52:31 +0100

Introduction: Basal Cell Carcinomas (BCC) and Squamous Cell Carcinomas (SCC) are malignant tumours that commonly present in the head and neck region. The ENT department excises over 200 skin lesions in a year. A previous audit in 2003 had shown an incomplete excision rate of 8.91% and recurrence rate of 2.7% among surgically treated BCC patients. (Source: International Journal of Surgery)

An Unusual Presentation of Idiopathic Basal Cell Carcinoma in an 8‐Year‐Old Child

Pediatric Dermatology — Tue, 04 Oct 2011 04:00:00 +0100

We report the unusual case of a young child who developed an idiopathic basal cell carcinoma (BCC). The patient was otherwise healthy, with no history of excessive sun or radiation exposure or any predisposing factors for nonmelanoma skin cancer. This is a rare case that exemplifies the need for pediatricians and dermatologists to be aware that BCC may occur in children, even if they have no predisposing factors. (Source: Pediatric Dermatology)