MedWorm: Borderline Endometrioid Tumor

Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)

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Low‐grade serous carcinomas of the ovary contain very few point mutations

The Journal of Pathology — Mon, 21 Nov 2011 05:00:00 +0100

AbstractIt has been well established that ovarian low‐grade and high‐grade serous carcinomas are fundamentally different types of tumours. While the molecular genetic features of ovarian high‐grade serous carcinomas are now well known, the pathogenesis of low‐grade serous carcinomas, apart from the recognition of frequent somatic mutations involving KRAS and BRAF, is largely unknown. In order to comprehensively analyze somatic mutations in low‐grade serous carcinomas, we applied exome sequencing to the DNA of eight samples of affinity‐purified low‐grade serous carcinomas. A remarkably small number of mutations were identified in seven of these tumours: a total of 70 somatic mutations in 64 genes. The eighth case displayed mixed serous and endometrioid features and a mutator p...

Accuracy of frozen section diagnosis of ovarian borderline tumor.

Gynecologic Oncology — Tue, 13 Sep 2011 04:00:00 +0100

CONCLUSION: Comprehensive surgical staging can be considered in BT >8cm in diameter, as well as those with micropapillary serous, endometrioid, and clear cell histology diagnosed at the time of frozen section analysis. PMID: 21920591 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Epithelial Ovarian Carcinoma Types and the Coexistence of Ovarian Tumor Conditions

Advances in Urology — Thu, 14 Jul 2011 17:39:48 +0100

Conclusion. One in six patients with a malignant ovarian tumor has a coexisting epithelial tumor condition in the ovary, which is also rather frequently observed in the diagnostic work-up practice. (Source: Advances in Urology)

Epiregulin as a marker for the initial steps of ovarian cancer development.

International Journal of Oncology — Wed, 13 Jul 2011 23:00:00 +0100

Authors: Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben-Arie A, Prus D, Schreiber L Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner. However, there were no systematic follow-up studies of Ep expression in the development of different stages of ovarian cancer. Using specific antibodies to Ep and the indirect immunocytochemistry methods, we found that in normal ovary the staining for Ep was mainly confined to the epithelial cells, while the stromal cells were only occasionally and moderately stained. In contrast in benign serous and mucinous tumors most of the tumor cells showed a clear staining in the cytoplasm. In borderline serous and mucinous tumors the staining was mu...

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Archives of Gynecology and Obstetrics — Wed, 29 Jun 2011 10:52:48 +0100

Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. Content Type Journal ArticlePages 1-5DOI 10.1007/s00404-011-1957-zAuthors A. Kondi-Pafiti, Pathology Laboratory, University of Athens, Athens, GreeceE. Papakonstantinou, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Iavazzo, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Grigoriadis, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofi...

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Stage IA Ovarian Cancers: Comparison of Sonographic Findings and Histopathologic Types Between Patients With Normal and Elevated Serum Cancer Antigen 125 Levels

Journal of Ultrasound in Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions— Stage IA ovarian cancers with normal CA-125 levels tend to be smaller, have less solid components, and have a slightly different distribution of histopathologic types than cancers with elevated CA-125 levels. (Source: Journal of Ultrasound in Medicine)

Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer.

Clinical Cancer Research — Wed, 25 May 2011 23:00:00 +0100

CONCLUSION: Based on findings indicated in a primary investigation set and confirmed in the large secondary validation set, we report for the first time plasma GDF-15 as a biomarker for endometrial cancer phenotype, including presence of lymph node metastasis and reduced survival. Its applicability as predictor of metastatic nodes and in monitoring treatment of endometrial cancer needs to be further studied. PMID: 21616994 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]

Radiographics recent issues — Wed, 11 May 2011 23:00:00 +0100

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelomic spread of disease beyond the ovaries, whereas low-grade serous and mucinous carcinomas commonly manifest w...

Ovarian borderline tumours: a review with emphasis on controversial areas

Diagnostic Histopathology — Tue, 29 Mar 2011 21:12:46 +0100

Abstract: Ovarian borderline tumours are relatively uncommon, but by no means rare, neoplasms. Most are of serous or mucinous type with other morphological variants being much more uncommon. This review discusses the pathological features and some clinical aspects of ovarian borderline tumours, concentrating on those of serous and mucinous type. Borderline endometrioid, Brenner and clear cell tumours are briefly discussed. Controversial and often poorly understood topics covered include the relationship between borderline tumours and carcinomas, the criteria for and significance of microinvasion, the significance of a micropapillary architecture in a serous borderline tumour, the diagnostic criteria for and significance of extraovarian “implants”, lymph node involvement, staging issues...

Ovarian cancer arising in endometrioid cysts: ultrasound findings

Ultrasound in Obstetrics and Gynecology — Wed, 23 Feb 2011 00:00:00 +0100

ConclusionsBorderline tumors and carcinomas arising in endometrioid cysts show a vascularised solid component at ultrasound examination, and this figure was present in all malignant transformation. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)

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"Surface epithelial changes" in uterine endometrioid carcinoma mimicking micropapillary serous borderline tumor of ovary: report of two cases and review of the literature

Diagnostic Pathology — Thu, 27 Jan 2011 00:00:00 +0100

This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important. (Source: Diagnostic Pathology)

Primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma

Annals of Diagnostic Pathology — Mon, 11 Oct 2010 04:00:00 +0100

We present a 58-year-old woman with primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma. Noninvolved ovary showed no Brenner tumor, endometriosis, transitional carcinoma, endometrioid adenocarcinoma, or typical multigerm layer classic mature teratoma. Moreover, no other primary site was possible because there were no prior or concomitant squamous carcinomas, or history of cervical intraepithelial neoplasia. The tumor showed strong positivity for p63 and CK5/6, reactivity that also extended from the squamous carcinoma into the basal-cell lining of the mucinous cyst of a likely monodermal teratoma. This basal-cell pattern was absent in a series of conventional benign and borderline cystic mucinous cystadenomas of the ovary, but clearly present in...

Borderline ovarian endometrioid tumor in adolescent: case report and review of the literature

Jornal Brasileiro de Patologia e Medicina Laboratorial — Sun, 18 Jul 2010 06:24:02 +0100

Os tumores endometrioides malignos ovarianos são neoplasias epiteliais raras em pacientes jovens. Enquanto os carcinomas endometrioides ovarianos acometem mulheres na quinta e na sexta décadas de vida, os tumores borderline acometem mulheres em uma faixa etária mais ampla (de 22 a 77 anos). Descreveremos a seguir um caso raro de tumor endometrioide borderline ocorrendo em paciente de 16 anos. Desde que tumores do saco vitelino (TSV) e de Sertoli-Leydig (TCSL) podem mimetizar morfologicamente tumor endometrioide, o uso da imuno-histoquímica, além dos aspectos morfológicos, foi fundamental para estabelecer o diagnóstico diferencial entre essas condições.Malignant endometrioid ovarian tumors are rare epithelial neoplasias among young patients. Whereas endometrioid ovarian carcinomas ...

Recreational physical activity and risk of epithelial ovarian cancer

Cancer Causes and Control — Tue, 01 Dec 2009 21:02:38 +0100

Conclusions Our findings are compatible with an overall reduction in risk of invasive epithelial ovarian cancer associated with recreational activity but suggest that this association may differ in women with different histologic types of disease. Inconsistent findings across studies that have considered histologic type indicate that this issue is not yet resolved. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9479-8Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in E...

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumors

Basic and Applied Pathology — Mon, 18 May 2009 04:00:00 +0100

Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)

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Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.

Gynecologic Oncology — Mon, 09 Mar 2009 04:00:00 +0100

CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors

Human Pathology — Mon, 09 Mar 2009 00:00:00 +0100

Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to serous borderline tumor or low-grade endometrioid tumor than to gastrointestinal mucinous borderline tumor by directly co...

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.

Human Pathology — Fri, 06 Mar 2009 05:00:00 +0100

Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to s...

Ovarian epithelial dysplasia after ovulation induction: time and dose effects

Human Reproduction — Mon, 08 Dec 2008 05:00:00 +0100

CONCLUSIONS There is probably a relationship between ovarian epithelial dysplasia and either ovulation inducing drugs or infertility. By Fathalla’s incessant ovulation theory, ‘the dose effect and the time effect’ of ovarian stimulation may explain ovarian dysplasia formation. (Source: Human Reproduction)

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors

Basic and Applied Pathology — Tue, 04 Nov 2008 05:00:00 +0100

Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)

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Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1

Archives of Gynecology and Obstetrics — Tue, 21 Oct 2008 06:12:08 +0100

Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saitama 350-1298 JapanMariko Fujita, Tokai University Department of Pathology, School of Medicine Tokyo JapanTakeshi Hirasawa, Tokai University Department of Obstetrics and Gy...

Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery

Cancer Causes and Control — Fri, 15 Aug 2008 07:10:36 +0100

Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAJennifer A. Doherty, Fred Hutchinson Cancer Researc...

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference

BioMed Central — Mon, 28 Jul 2008 04:00:00 +0100

The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern regional Cooperative Human Tissue Network (CHTN) and University of Alabama-Birmingham (UAB) Ovarian Spore Center. Thirty-nine mtDNA variants were detected of which 28 were p...

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.

Cancer Control — Sat, 14 Jun 2008 20:37:38 +0100

We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no associ...

Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors.

Human Pathology — Mon, 12 May 2008 04:00:00 +0100

Authors: Romero-Sánchez M, Peiper SC, Evans B, Wang Z, Catasús L, Ribe A, Prat J, Giri JG A novel class of putative progestin binding proteins has been recently identified as potential mediators of rapid nongenomic hormone actions. The proteins designated membrane progestin receptor (mPR) alpha, beta, and gamma were initially discovered in fish and shown to have a role in oocyte maturation. The predicted multiple membrane spanning domain structure of the mPRs resembles that of heptahelical G-protein-coupled receptors. Phylogenetic analysis indicated that the mPRs belong to the large progestin and adiponectin Q receptor (PAQR) gene family. Based on the reported expression of the 3 mPRs in hormone-responsive tissues of the female reproductive tract and on the role of steroid ho...

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Body size and risk of epithelial ovarian and related cancers: A population-based case-control study

International Journal of Cancer — Wed, 30 Apr 2008 04:00:00 +0100

[My approach] My approach to and thoughts on the typing of ovarian carcinomas

Journal of Clinical Pathology — Fri, 25 Jan 2008 05:00:00 +0100

Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the distinction between high-grade serous and endometrioid adenocarcinomas and the distinction between a true clear cell carcinoma and clear cell areas within other adenocarcinom...

Atypical endometriosis: a clinicopathologic study of 163 cases

Chinese Journal of Clinical Oncology — Mon, 14 Jan 2008 03:45:12 +0100

Conclusion AEM lesions have some features which are similar and also differ from both of the tumor and EM. AEMs have a relative higher potential for tumorigenesis and canceration, especially for ovarian cancer. The process of damage, repair, and scarring in EM foci over a long period may play a role in the development of EM into AEM and eventally into tumor formation. Content Type Journal ArticleDOI 10.1007/s11805-007-0405-0Authors Donghui Guo, Tianjin Central Obstetrics & Gynecology Hospital Department of Pathology Tianjin 300052 ChinaShujie Pang, Tianjin Central Obstetrics & Gynecology Hospital Department of Pathology Tianjin 300052 ChinaYan Shen, Tianjin Central Obstetrics & Gynecology Hospital Department of Pathology Tianjin 300052 China Journal Chinese Jou...

Overexpression of mammaglobin B in epithelial ovarian carcinomas.

Gynecologic Oncology — Mon, 05 Mar 2007 05:00:00 +0100

CONCLUSIONS: Mammaglobin B gene is highly expressed in EOC and may represent a novel molecular marker for multiple histological types of ovarian cancer. Additional studies to evaluate the clinical utility of Mammaglobin B as a diagnostic and/or therapeutic target in ovarian cancer are warranted. PMID: 17343903 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages

Journal of Carcinogenesis — Fri, 26 Jan 2007 07:00:00 +0100

Conclusion: Our findings indicate that certain mtDNA mutations can reliably distinguish the different histologic subtypes of epithelial ovarian tumors. In addition, these data raise the possibility that certain mtDNA mutations may be useful biomarkers for predicting tumor aggressiveness and may play a potential role in tumorigenesis. (Source: Journal of Carcinogenesis)

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Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer

Cancer — Tue, 19 Sep 2006 22:39:02 +0100

The objectives of this study were to analyze the real role that these pathways play in ovarian cancer, to correlate them with clinicopathologic characteristics, and to identify the factors that transmit individual proliferation signals and are associated with pathologic grade and prognosis, regardless specific oncogenic alterations upstream.One hundred twenty-nine ovarian epithelial tumors were studied, including 20 serous cystadenomas, 7 mucinous cystadenomas, 11 serous borderline tumors, 16 mucinous borderline tumors, 29 serous carcinomas, 16 endometrioid carcinomas, 15 clear cell carcinomas, and 15 mucinous carcinomas. Tissue microarrays were constructed, and immunohistochemistry for the receptors epidermal growth factor receptor (EGFR) and c-erb-B2 was performed and with phosphorylated...