MedWorm: Borderline Mucinous Tumor

The value of frozen section evaluation in the management of borderline ovarian tumors

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: In the frozen section evaluation of BOTs, the underdiagnosis that restricts the diagnostic performance of the method seems to be a major problem. A more careful approach is therefore needed, while choosing a proper surgical technique during laparotomy for ovarian masses. In order to reduce the false diagnosis and surgical morbidity, the frozen section analysis should be applied by experienced pathologists and the possible predictive factors affecting a false diagnosis should carefully be taken into consideration. (Source: Journal of Cancer Research and Therapeutics)

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Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)

Pylorus- and spleen-preserving total pancreatoduodenectomy with resection of both whole splenic vessels: feasibility and laparoscopic application to intraductal papillary mucin-producing tumors of the pancreas

Surgical Endoscopy — Thu, 12 Jan 2012 06:41:01 +0100

Conclusions PpSpTPD with segmental resection of both splenic vessels is feasible and safe. Even a minimally invasive approach can be indicated in selected patients. Content Type Journal ArticleCategory Dynamic ManuscriptPages 1-6DOI 10.1007/s00464-011-2113-3Authors Sung Hoon Choi, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaHo Kyoung Hwang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaChang Moo Kang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaChang Ik Yoo...

Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors

Archives of Gynecology and Obstetrics — Sat, 24 Dec 2011 16:41:54 +0100

In conclusion, Brenner ovarian tumors are unilateral, small and benign neoplasms in their majority and present specific histopathological and immunopathological characteristics and mixed forms with other epithelial and germ cell neoplasms. This could be explained as a form of metaplasia or a diverse histogenesis from surface epithelium and/or the germ cell ovarian component. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2182-5Authors A. Kondi-Pafiti, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceEvi Kairi-Vassilatou, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceCh. Iavazzo, 2nd Clinic of Obstetrics and Gynecology, Aretaieion University Hospit...

Unexpected ovarian malignancy after conservative laparoscopic surgery: five case series in a half decade of experience

Archives of Gynecology and Obstetrics — Wed, 21 Dec 2011 20:07:58 +0100

Conclusion The main concern for laparoscopic management of ovarian masses is unexpected malignancy. However, with careful patient selection, proper technique and an experienced operator, laparoscopic treatment of ovarian masses is the best approach and should be implemented, with low risk of unexpected malignancy and recurrence. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2177-2Authors Noraziana Abd Wahab, Department of Obstetrics and Gynecology, Kulliyyah of medicine, Jalan Hospital, International Islamic University, 25710 Kuantan, Pahang, MalaysiaAmphan Chalermchockchareonkit, Department of Obstetrics and Gynecology, Thai-German Multidisciplinary Endoscopic Training Center, Faculty of Medicine Siriraj Hospital, Mahidol ...

Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution

Pediatric Surgery International — Wed, 16 Nov 2011 18:00:12 +0100

Conclusions The majority of pediatric ovarian tumors were benign disease, and the patients with malignant lesions had a good prognosis. In neonatal cases, an umbilical crease incision approach is feasible and provides excellent cosmesis. We recommend tumor resection with ovarian preservation through a minimally invasive approach (modified Rocky Davis incision) as the first line treatment for older pediatric patients with ovarian tumors other than those preoperatively diagnosed as malignant. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s00383-011-3004-3Authors Tatsuro Tajiri, Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanRyota Souzaki, Departmen...

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Laparoscopic management of large ovarian tumors: Clinical tips for overcoming common concerns

Journal of Obstetrics and Gynaecology Research — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion: Laparoscopic management of large ovarian tumors is feasible and efficient with appropriate patient selection and experience of surgeons. (Source: Journal of Obstetrics and Gynaecology Research)

Leak-proof extracorporeal drainage for management of large ovarian tumors

Archives of Gynecology and Obstetrics — Fri, 21 Oct 2011 16:00:26 +0100

Conclusions Minilaparotomy with leak-proof extracorporeal drainage using cyanoacrylate adhesive and polyurethane membrane is reliable, safe, and feasible for management of large ovarian tumors with low probability of malignancy in selected patients. Content Type Journal ArticleCategory General GynecologyPages 1-4DOI 10.1007/s00404-011-2115-3Authors Shih-Shien Weng, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 TaiwanYeou-Lih Wang, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 Taiwan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

A case of ovarian mucinous adenocarcinoma in a premenarcheal girl

International Journal of Clinical Oncology — Fri, 21 Oct 2011 05:55:13 +0100

We report a case of a 12-year-old premenarcheal girl who developed ovarian mucinous adenocarcinoma. The tumor, which originated from the right ovary, weighed 1400 g, and had a smooth surface and thin capsule, was extirpated. The cut surface showed multilocular cysts of various sizes and yellowish gelatinous to solid parts that accounted for approximately 40% of the cut surface. The histological findings showed a continuous mixture of mucinous adenoma, mucinous borderline tumor, and mucinous adenocarcinoma with an expansile invasive pattern. It was assumed that an ovarian mass developed in an early period after birth or infancy, and the mutation of certain oncogens occurred in an early period, leading to cancer. While some etiological hypotheses concerning ovarian carcinogenesis ...

Primary peritoneal borderline mucinous cystadenofibroma

Archives of Gynecology and Obstetrics — Wed, 05 Oct 2011 05:49:39 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00404-011-2100-xAuthors Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231, Shimizu-ku, Shizuoka, 424-8636 Japan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Epithelial Ovarian Tumors in Adolescents: A Retrospective Pathologic Study and a Critical Review of the Literature

Journal of Pediatric and Adolescent Gynecology — Mon, 26 Sep 2011 04:00:00 +0100

Conclusions: A relatively high frequency of epithelial ovarian neoplasms among all ovarian tumors in a purely adolescent population was found in our study. Age-related selection bias may account at least in part for the discrepancy between our data and most previous reports. The most common subtype of epithelial ovarian tumor in our series was the benign serous cystadenoma. (Source: Journal of Pediatric and Adolescent Gynecology)

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Accuracy of frozen section diagnosis of ovarian borderline tumor.

Gynecologic Oncology — Tue, 13 Sep 2011 04:00:00 +0100

CONCLUSION: Comprehensive surgical staging can be considered in BT >8cm in diameter, as well as those with micropapillary serous, endometrioid, and clear cell histology diagnosed at the time of frozen section analysis. PMID: 21920591 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Intra-operative frozen section analysis for suspected early-stage ovarian cancer: 11 years of Gateshead Cancer Centre experience.

BJOG : An International Journal of Obstetrics and Gynaecology — Tue, 06 Sep 2011 04:00:00 +0100

Conclusions Intra-operative FS analysis has excellent diagnostic test accuracy and assists gynaecological oncologists to perform the appropriate surgery in 95% of cases, thereby preventing the morbidity of surgical staging in benign cases and the morbidity of restaging procedures or chemotherapy in early-stage malignant tumours. PMID: 21895958 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Intra‐operative frozen section analysis for suspected early‐stage ovarian cancer: 11 years of Gateshead Cancer Centre experience

BJOG: An International Journal of Obstetrics and Gynaecology — Mon, 05 Sep 2011 23:00:00 +0100

Conclusions Intra‐operative FS analysis has excellent diagnostic test accuracy and assists gynaecological oncologists to perform the appropriate surgery in 95% of cases, thereby preventing the morbidity of surgical staging in benign cases and the morbidity of restaging procedures or chemotherapy in early‐stage malignant tumours. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

Primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient. Case report and review of the literature.

BioMed Central — Fri, 26 Aug 2011 23:00:00 +0100

Conclusion: This is the third case of primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient reported in the literature. The preoperative diagnosis is impossible. Laparotomy constitutes the only diagnostic and curative approach. (Source: BioMed Central)

Fine needle aspiration cytology in ovarian lesions: an institutional experience of 584 cases

Cytopathology — Wed, 24 Aug 2011 23:00:00 +0100

Conclusion: FNAC has a high specificity for diagnosis of ovarian/adnexal lesions but greater experience is required for the accurate subtyping of neoplasms and sensitivity is limited by inconclusive/inadequate results. (Source: Cytopathology)

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Metastatic urachal carcinoma of the ovary

Journal of Obstetrics and Gynaecology Research — Tue, 26 Jul 2011 23:00:00 +0100

AbstractA 52‐year‐old woman had undergone a partial cystectomy for a cystic mass at the dome of the urinary bladder in 1997. The pathological diagnosis was a urachal mucinous cystadenoma with borderline malignancy. Twelve years later, multiple masses were noted on the uterus, ovaries and abdominal wall. She underwent debulking surgery, including a total hysterectomy, bilateral salpingo‐oophorectomy, pelvic lymph node dissection, infracolic omentectomy, appendectomy, colon mass removal and abdominal wall mass removal. Remnants of the tumor were seeded throughout the abdominal cavity. The pathological evaluation confirmed metastatic urachal mucinous adenocarcinoma in both ovaries, the abdominal wall, the colon mass, the uterosacral ligament and the bladder. Adjuvant chemotherapy with p...

Epithelial Ovarian Carcinoma Types and the Coexistence of Ovarian Tumor Conditions

Advances in Urology — Thu, 14 Jul 2011 17:39:48 +0100

Conclusion. One in six patients with a malignant ovarian tumor has a coexisting epithelial tumor condition in the ovary, which is also rather frequently observed in the diagnostic work-up practice. (Source: Advances in Urology)

Epiregulin as a marker for the initial steps of ovarian cancer development.

International Journal of Oncology — Wed, 13 Jul 2011 23:00:00 +0100

Authors: Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben-Arie A, Prus D, Schreiber L Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner. However, there were no systematic follow-up studies of Ep expression in the development of different stages of ovarian cancer. Using specific antibodies to Ep and the indirect immunocytochemistry methods, we found that in normal ovary the staining for Ep was mainly confined to the epithelial cells, while the stromal cells were only occasionally and moderately stained. In contrast in benign serous and mucinous tumors most of the tumor cells showed a clear staining in the cytoplasm. In borderline serous and mucinous tumors the staining was mu...

Prospective randomized controlled study comparing cell block method and conventional smear method for pancreatic juice cytology

Digestive Endoscopy — Tue, 12 Jul 2011 23:00:00 +0100

Conclusions: The CB method using immunostaining for pancreatic juice cytology showed a much lower rate of equivocal borderline malignancy and a tendency for a higher diagnostic yield compared with smear cytology. Its diagnostic sensitivity, however, was not satisfactory except for pancreatic‐head cancer. (Source: Digestive Endoscopy)

Stage IA Ovarian Cancers: Comparison of Sonographic Findings and Histopathologic Types Between Patients With Normal and Elevated Serum Cancer Antigen 125 Levels

Journal of Ultrasound in Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions— Stage IA ovarian cancers with normal CA-125 levels tend to be smaller, have less solid components, and have a slightly different distribution of histopathologic types than cancers with elevated CA-125 levels. (Source: Journal of Ultrasound in Medicine)

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Determination of malignant and invasive predictors in branch duct type intraductal papillary mucinous neoplasms of the pancreas: a suggested scoring formula.

J Korean Med Sci — Tue, 31 May 2011 23:00:00 +0100

Authors: Hwang DW, Jang JY, Lim CS, Lee SE, Yoon YS, Ahn YJ, Han HS, Kim SW, Kim SG, Yun YK, Han SS, Park SJ, Lim TJ, Kang KJ, Sim MS, Choi SH, Heo JS, Choi DW, Hur KY, Lee DS, Yun SS, Kim HJ, Cho CK, Kim HJ, Yu HC, Cho BH, Song IS Prediction of malignancy or invasiveness of branch duct type intraductal papillary mucinous neoplasm (Br-IPMN) is difficult, and proper treatment strategy has not been well established. The authors investigated the characteristics of Br-IPMN and explored its malignancy or invasiveness predicting factors to suggest a scoring formula for predicting pathologic results. From 1994 to 2008, 237 patients who were diagnosed as Br-IPMN at 11 tertiary referral centers in Korea were retrospectively reviewed. The patients' mean age was 63.1 ± 9.2 yr. One hundred ninty-...

Laparoendoscopic single-site surgery (LESS) for adnexal tumors: one surgeon's initial experience over a one-year period

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 16 May 2011 04:00:00 +0100

Conclusions: Our results suggest that LESS is a safe and feasible alternative to conventional laparoscopic surgery for the treatment of adnexal tumors. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]

Radiographics recent issues — Wed, 11 May 2011 23:00:00 +0100

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelomic spread of disease beyond the ovaries, whereas low-grade serous and mucinous carcinomas commonly manifest w...

Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules

Annals of Nuclear Medicine — Mon, 02 May 2011 14:59:49 +0100

Conclusions The result of this study indicates that FDG PET/CT can provide additional information for the differentiation between benign and malignant IPMNs of the pancreas with mural nodules. Content Type Journal ArticlePages 1-10DOI 10.1007/s12149-011-0494-yAuthors Kentaro Takanami, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanTomomichi Hiraide, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanMasashi Tsuda, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanYasuhiro Nakamura, Department of Pathology, Tohoku University Graduate Sc...

[An ovarian mucinous borderline tumour with mixed mural nodules.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Wed, 27 Apr 2011 23:00:00 +0100

We report an additional case of mixed type mural nodules of anaplastic carcinoma and sarcoma-like developed in an ovarian mucinous borderline tumour at a 60-year-old woman.We give details about the classification, the differential diagnosis and prognosis of theses nodules. PMID: 21531088 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

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Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy

Advances in Pharmacological Sciences — Tue, 26 Apr 2011 14:23:42 +0100

Conclusions. Despite the small number of samples used in this study, the results indicate that metabolomic analysis of intact tissues by HRMAS-NMR is a promising technique which might be applicable to the therapeutic management of patients. (Source: Advances in Pharmacological Sciences)

The first experience of robot assisted spleen-preserving laparoscopic distal pancreatectomy in Korea.

Yonsei Medical Journal — Thu, 21 Apr 2011 22:00:30 +0100

Authors: Kim DH, Kang CM, Lee WJ, Chi HS Spleen-preservation has recently been emphasized in benign and borderline malignant pancreatic diseases requiring distal pancreatectomy. Reports to suggest that laparoscopic distal pancreatectomy is feasible and safe have been increasingly published. Robotic surgical system has been introduced and is expected to provide unique advantages in laparoscopic surgery. However, robot-assisted pancreatic surgery has not yet been performed by many surgeons. A 45-year-old female patient with abdominal discomfort was found to have pancreatic cyst in the body of the pancreas. Mucinous cystic tumor of the pancreas was the most favourable preoperative diagnosis. She underwent spleen-preserving laparoscopic distal pancreatectomy by using da Vinci surgical robo...

Primary pancreatic cystic neoplasms revisited: Part II. Mucinous cystic neoplasms

Surgical Oncology — Thu, 14 Apr 2011 00:34:21 +0100

Abstract: Mucinous cystic neoplasms (MCNs) of the pancreas represent one of the most common primary pancreatic cystic neoplasms, accounting for approximately half of these cases. MCNs are observed almost exclusively in women, and most commonly are located in the body/tail of the pancreas. In contrast to SCNs, MCNs have malignant potential. Proliferative changes (hyperplasia with or without atypia, borderline changes, non-invasive or carcinomas in-situ, and invasive carcinomas) can often be observed within the same neoplasm. Several risk factors for the presence of underlying malignancy within an MCN have recently been recognized. Cross-sectional imaging is of key importance for the diagnostic evaluation of patients with a cystic pancreatic lesion. Cyst fluid examination (cytology, biochemi...

Accuracy of frozen section diagnosis of borderline ovarian tumors.

Gynecologic Oncology — Mon, 11 Apr 2011 23:00:00 +0100

CONCLUSIONS: Frozen section analysis of BOTs has low accuracy, sensitivity, and positive predictive value, and underdiagnosis and overdiagnosis are frequent. Therefore, surgical decision-making for BOTs based on frozen section diagnosis should be done carefully, especially in tumors with mucinous histology. PMID: 21492922 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Ovarian borderline tumours: a review with emphasis on controversial areas

Diagnostic Histopathology — Tue, 29 Mar 2011 21:12:46 +0100

Abstract: Ovarian borderline tumours are relatively uncommon, but by no means rare, neoplasms. Most are of serous or mucinous type with other morphological variants being much more uncommon. This review discusses the pathological features and some clinical aspects of ovarian borderline tumours, concentrating on those of serous and mucinous type. Borderline endometrioid, Brenner and clear cell tumours are briefly discussed. Controversial and often poorly understood topics covered include the relationship between borderline tumours and carcinomas, the criteria for and significance of microinvasion, the significance of a micropapillary architecture in a serous borderline tumour, the diagnostic criteria for and significance of extraovarian “implants”, lymph node involvement, staging issues...

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Fertility determinants after conservative surgery for mucinous borderline tumours of the ovary (excluding peritoneal pseudomyxoma)

Human Reproduction — Tue, 15 Mar 2011 00:00:00 +0100

CONCLUSIONS The use of salpingo-oophorectomy rather than cystectomy should be preferred during conservative surgery for patients with MBOTs because it decreases the risk of recurrence and does not impair fertility. (Source: Human Reproduction)

Isobaric laparoendoscopic single-site surgery with wound retractor for adnexal tumors: a single center experience with the initial 100 cases

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 14 Mar 2011 00:00:00 +0100

Conclusions: With efficient wound retraction to create a wide and flexible orifice during instrumentation, the transumbilical wound retraction system combined with the subcutaneous abdominal wall-lift method contributes favorably to LESS surgery as a safe, feasible and reproducible alternative for a variety of ablative and reconstructive applications in the management of adnexal tumors. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Serum anti‐glycan antibody detection of non‐mucinous ovarian cancers by using a printed glycan array

International Journal of Cancer — Wed, 23 Feb 2011 00:00:00 +0100

AbstractEpithelial Ovarian cancer has the highest mortality rate among gynaecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor‐associated carbohydrate antigens. We investigated the potential of natural occurring anti‐glycan antibodies in the diagnosis of ovarian cancer by using printed glycan array.Anti‐glycan antibodies bound to 203 chemically synthesized printed glycans were detected via biotin‐streptavidin fluorescence system in serum of women with normal operative findings (healthy controls; n=24) and non‐mucinous borderline or ovarian cancer of various FIGO stages (n=33). Data were validated measuring blood group associated di‐, tri and tetra‐ saccharide antigens on known ABO blood groups.Anti‐glycan antibodies demonstr...

Benign cystic peritoneal mesothelioma incorrectly diagnosed as an ovarian borderline mucinous tumor of intestinal type at transvaginal preoperative ultrasound evaluation.

The Ultrasound Review of Obstetrics and Gynecology — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Testa AC, Zannoni GF, Ferrari S, Lecca A, Marana E, Marana R PMID: 21264984 [PubMed - in process] (Source: The Ultrasound Review of Obstetrics and Gynecology)

"Surface epithelial changes" in uterine endometrioid carcinoma mimicking micropapillary serous borderline tumor of ovary: report of two cases and review of the literature

Diagnostic Pathology — Thu, 27 Jan 2011 00:00:00 +0100

This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important. (Source: Diagnostic Pathology)

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On or in the liver? Two cases with diffuse pseudomyxoma peritonei and synchronous hepatic pathology

Techniques in Coloproctology — Wed, 19 Jan 2011 20:23:14 +0100

We report 2 cases of patients who had diffuse PMP with synchronous hepatic pathology to highlight the need for vigilance and appropriate assessment of coincidental liver lesions. An assessment and management strategy is outlined. Content Type Journal ArticlePages 1-3DOI 10.1007/s10151-010-0671-3Authors H. Youssef, Department of Pseudomyxoma Surgery, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, Hampshire, UKB. J. Moran, Department of Pseudomyxoma Surgery, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, Hampshire, UK Journal Techniques in ColoproctologyOnline ISSN 1128-045XPrint ISSN 1123-6337 (Source: Techniques in Coloproctology)

High-Throughput Mutation Profiling in Intraductal Papillary Mucinous Neoplasm (IPMN)

Journal of Gastrointestinal Surgery — Wed, 12 Jan 2011 06:51:27 +0100

Conclusions Of the 22 screened tumor-related genes, only K-ras, p53, and PIK3CA mutations were found in IPMN. K-ras mutations are more prevalent in invasive than premalignant IPMN. The variable coexistence of mutations in the invasive cancer and in the adjacent precursor cells may point to the heterogeneous nature of this tumor. Content Type Journal ArticlePages 1-9DOI 10.1007/s11605-010-1411-8Authors Nir Lubezky, Department of Surgery B, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, 6 Weitzman St., Tel Aviv, 64239 IsraelMenahem Ben-Haim, Department of Surgery B, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, 6 Weitzman St., Tel Aviv, 64239 IsraelSylvia Marmor, The Pathological Institute, Tel-A...

Molecular Characterization of 103 Ovarian Serous and Mucinous Tumors.

Pathology Oncology Research — Tue, 07 Dec 2010 00:00:00 +0100

Authors: Vereczkey I, Serester O, Dobos J, Gallai M, Szakács O, Szentirmay Z, Tóth E The pathogenesis of ovarian carcinomas is heterogeneous, with even the same entities showing great variance. In our study we investigated the mutations of the BRAF, KRAS, and p53 genes in serous and mucinous borderline tumors and in low grade and high grade serous and mucinous tumors. The mutations of BRAF and KRAS genes have been shown in 60% of borderline and low grade (well differentiated) serous and mucinous tumors, but very rarely in high grade (moderately and poorly differentiated) carcinomas. However mutations of p53 are very common in high grade tumors and this indicates a "dualistic" model of ovarian tumorigenesis. A total of 80 serous tumors, including serous borderline, low grade and high ...

Appendiceal pathology at the time of oophorectomy for ovarian neoplasms.

Obstetrics and Gynecology — Mon, 29 Nov 2010 19:47:46 +0100

CONCLUSION:: The prevalence of coexisting, clinically significant appendiceal pathology is low with a frozen section diagnosis of serous or mucinous cystadenoma. Appendectomy is recommended when frozen section diagnosis is mucinous or serous ovarian carcinoma, borderline tumor or metastatic carcinoma of suspected gastrointestinal origin. LEVEL OF EVIDENCE:: III. PMID: 21099601 [PubMed - in process] (Source: Obstetrics and Gynecology)

Benign cystic peritoneal mesothelioma incorrectly diagnosed as an ovarian borderline mucinous tumor of intestinal type at transvaginal preoperative ultrasound evaluation.

The Ultrasound Review of Obstetrics and Gynecology — Wed, 27 Oct 2010 23:00:00 +0100

Authors: Testa AC, Zannoni GF, Ferrari S, Lecca A, Marana E, Marana R PMID: 21031350 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

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Primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma

Annals of Diagnostic Pathology — Mon, 11 Oct 2010 04:00:00 +0100

We present a 58-year-old woman with primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma. Noninvolved ovary showed no Brenner tumor, endometriosis, transitional carcinoma, endometrioid adenocarcinoma, or typical multigerm layer classic mature teratoma. Moreover, no other primary site was possible because there were no prior or concomitant squamous carcinomas, or history of cervical intraepithelial neoplasia. The tumor showed strong positivity for p63 and CK5/6, reactivity that also extended from the squamous carcinoma into the basal-cell lining of the mucinous cyst of a likely monodermal teratoma. This basal-cell pattern was absent in a series of conventional benign and borderline cystic mucinous cystadenomas of the ovary, but clearly present in...

Pediatric borderline ovarian tumors: a retrospective analysis

Journal of Pediatric Surgery — Thu, 30 Sep 2010 23:00:00 +0100

Conclusions: This study shows that BOTs in pediatric populations can be successfully treated conservatively to preserve fertility with no apparent increased risk of morbidity or mortality compared with those of more radical surgical options. (Source: Journal of Pediatric Surgery)

Endocervical‐like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation

Histopathology — Thu, 30 Sep 2010 23:00:00 +0100

Kim K‐R, Choi J, Hwang J‐E, Baik Y‐A, Shim J Y, Kim Y M & Robboy S J (2010) Histopathology (Source: Histopathology)

Expression of octamer-4 in serous and mucinous ovarian carcinoma

Journal of Clinical Pathology — Mon, 27 Sep 2010 16:04:19 +0100

Conclusion Results suggest that Oct4 expression may contribute to the initiation, promotion and progression of serous ovarian carcinoma; it might be a useful biomarker for the diagnosis and outcome prediction of serous ovarian carcinoma. (Source: Journal of Clinical Pathology)

Prognostic Factors of a Large Retrospective Series of Mucinous Borderline Tumors of the Ovary (Excluding Peritoneal Pseudomyxoma)

Annals of Surgical Oncology — Wed, 25 Aug 2010 06:13:29 +0100

Conclusions In the present series of 97 MBOT, mainly early-stage disease and excluding peritoneal pseudomyxoma, the cumulative risk of recurrence in the form of invasive carcinoma at 10 years was 13%. MBOT do not appear to be such a “safe” disease. The only prognostic factor for recurrence was the use of a cystectomy, suggesting that a salpingo-oophorectomy should be preferred in cases of conservative treatment. Content Type Journal ArticleDOI 10.1245/s10434-010-1293-8Authors Martin Koskas, Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, FranceCatherine Uzan, Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, FranceSebastien Gouy, Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, FrancePatrici...

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Serous and mucinous borderline ovarian tumors: are there real differences between these two entities?

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Wed, 11 Aug 2010 00:00:00 +0100

Abstract: Objective: To evaluate the clinical outcome and pathological features of patients with borderline ovarian tumors (BOT) with special emphasis on serous and mucinous histology.Study design: Medical and anatomopathological records were reviewed in the Gynecological Oncology Department of the Canarian University Hospital between 1990 and 2005. Survival rates were analyzed by using the Kaplan–Meier technique.Results: The study included 163 patients. Serous tumors corresponded to 68 cases and mucinous tumors to 91 cases. Eighty-nine percent of patients were at FIGO stage I, 1.2% at stage II and 9.8% at stage III. Serous histology was significantly related to the presence of peritoneal implants (22.4% vs 3.6%; p=0.001), positive peritoneal cytology (35.7% vs 8.5%; p=0.001) and bilater...

Clinical‐Scientific Notes: Pseudomyxoma Peritonei arising from a mucinous borderline ovarian tumour: Case report and literature review

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Sat, 31 Jul 2010 23:00:00 +0100

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Mucinous cystic neoplasms of the pancreas: how much preoperative evaluation is needed?

The American Surgeon — Sat, 31 Jul 2010 23:00:00 +0100

Authors: Theruvath TP, Morgan KA, Adams DB Cystic lesions of the pancreas are identified with increasing frequency by modern imaging. The mucinous cystic neoplasm (MCN) is treated with resection for its malignant potential. How much preoperative evaluation is needed before undertaking operation is frequently a diagnostic dilemma. A retrospective review of 32 patients who underwent resection of a MCN between 1994 and 2007 was performed to define the preoperative evaluation and operative treatment of MCN patients. Thirty-two patients (30 women; mean age 49) had histology-proven MCN. Twenty-seven patients had symptomatic cysts (84%). Five had a history of gallstones and/or acute pancreatitis. All patients were worked up with CT and/or MRI. Endoscopic ultrasound was performed in 14 (44%) a...

Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation

Human Pathology — Sun, 25 Jul 2010 23:00:00 +0100

In conclusion, programmed cell death 4 may inhibit tumor progression in intraductal papillary mucinous neoplasm; and the loss of programmed cell death 4 expression is representative of the malignant potential of intraductal papillary mucinous neoplasm including the proliferative activity. Therefore, programmed cell death 4 can be an important biomarker for intraductal papillary mucinous neoplasm. (Source: Human Pathology)

Clinicopathologic analysis of surgically proven intraductal papillary mucinous neoplasms of the pancreas in SNUH: a 15-year experience at a single academic institution

Langenbeck's Archives of Surgery — Sat, 17 Jul 2010 21:10:21 +0100

Conclusions The main pancreatic duct diameter (>5 mm) is a significant predictor for malignancy and invasiveness. Therefore, IPMN patients with main pancreatic duct dilatation (>5 mm) should be considered surgical resection. Mural nodule is the indicator of surgery in IPMN-Br and IPMN-Mixed. In case of IPMN-Mixed with wall thickening or elevated serum CA19-9, surgical resection is recommended. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00423-010-0674-6Authors Dae Wook Hwang, Seoul National University College of Medicine Department of Surgery 28 Yongon-dong, Chongno-gu Seoul 110-744 South KoreaJin-Young Jang, Seoul National University College of Medicine Department of Surgery 28 Yongon-dong, Chongno-gu Seoul 110-744 South KoreaS...

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Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period.

JOP — Mon, 12 Jul 2010 16:27:04 +0100

CONCLUSION: Cystic lesions are found in 20.6% of all pancreatectomy specimens. Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining. Age at presentation, gender, location and tumor size are highly variable, with the exception of solid pseudopapillary tumor. Clinical presentation, diagnostic imaging and laboratory data should be consistently reported to improve the therapeutic approach. PMID: 20601810 [PubMed - in process] (Source: JOP)

Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas

Human Pathology — Sun, 11 Jul 2010 23:00:00 +0100

In conclusion, CD24 is involved in the progression of intraductal papillary mucinous neoplasms of the pancreas and in the malignant behavior of pancreatic cancers. (Source: Human Pathology)

Pseudomyxoma Peritonei arising from a mucinous borderline ovarian tumour: Case report and literature review

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Thu, 24 Jun 2010 23:00:00 +0100

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Risk of malignancy in sonographically confirmed septated cystic ovarian tumors.

Gynecologic Oncology — Sun, 13 Jun 2010 23:00:00 +0100

CONCLUSIONS: Septated cystic ovarian tumors without solid areas or papillary projections have a low risk of malignancy and can be followed sonographically without surgery. PMID: 20554314 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Middle-preserving pancreatectomy: an interesting procedure for pancreas-sparing resection.

JOP — Fri, 07 May 2010 22:24:03 +0100

CONCLUSION: A middle-preserving pancreatectomy can be performed safely for multicentric IPMNs involving the head and the body-tail of the gland. It can prevent problems with the glycemic control that usually follows total pancreatectomy. PMID: 20442523 [PubMed - in process] (Source: JOP)

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T1447: Mucus Nodule of the Endoscopic Ultrasonographic Finding Is One of the Most Important Diagnostic Factors of the Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas

Gastrointestinal Endoscopy — Wed, 31 Mar 2010 23:00:00 +0100

The preoperative diagnosis of intraductal papillary mucinous neoplasms(IPMN) of the pancreas must be as reliable as possible because large pancreatectomy may be necessary. But it was very difficult that especially, diagnosis of branch duct type IPMNs wasn't satisfied to distinguish malignant from benign even with using cytological analysis of cystic fluid. Endoscopic ultrasonography(EUS) is one of the most reliable imaging modalities of branch duct type IPMNs. The purpose of this study was to evaluate the preoperative diagnostic value of EUS in differentiating benign(adenoma and borderline malignant) and malignant(carcinoma in situ and invasive carcinoma) IPMNs. (Source: Gastrointestinal Endoscopy)

Expression of Sox2 in human ovarian epithelial carcinoma

Journal of Cancer Research and Clinical Oncology — Fri, 26 Mar 2010 19:19:27 +0100

Conclusion The expression level of Sox2 in human ovarian tumors was directly proportional to their degree of malignancy, implying that Sox2 overexpression may be closely related to the malignant transformation of ovarian tumors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0867-yAuthors Feng Ye, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine Xueshi Rd#2 Hangzhou 310006 ChinaYanli Li, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine Xueshi Rd#2 Hangzhou 310006 ChinaYing Hu, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School ...

Stromal thrombospondin-1 expression is a prognostic indicator and a new marker of invasiveness in intraductal papillary-mucinous neoplasm of the pancreas.

Biomed Res — Tue, 09 Mar 2010 11:06:03 +0100

In conclusion, stromal TSP1 expression is a prognostic indicator and a new marker of invasiveness in IPMN. PMID: 20203415 [PubMed - in process] (Source: Biomed Res)

Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis

European Journal of Cancer — Mon, 08 Mar 2010 00:00:00 +0100

Abstract: Oxidative stress and antioxidant enzymes have been widely investigated in various carcinomas. However, there is only some information about their role in ovarian carcinogenesis or in ovarian carcinomas in vivo. We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins (PRDX) I–VI and thioredoxin (TXN) in ovarian tumours. The material consisted of 20 benign (10 serous, 10 mucinous) and 51 borderline (33 serous, 18 mucinous) epithelial ovarian tumours. The markers of oxidative stress, 8-OHdG and nitrotyrosine, were seen already in benign tumours (in 20% and 45% of the tumours, respectively) and their expression patterns were similar in b...

Serum CA19.9 levels are commonly elevated in primary ovarian mucinous tumours but cannot be used to predict the histological subtype

Journal of Clinical Pathology — Fri, 12 Feb 2010 10:25:41 +0100

Conclusion Preoperative CA19.9 levels cannot be used to predict whether a suspected ovarian mucinous tumour is benign, borderline or malignant. Markedly elevated serum levels (>1000 U/ml) may be found in benign mucinous neoplasms as well as in borderline and malignant tumours. (Source: Journal of Clinical Pathology)

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Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas

Journal of Gastroenterology — Wed, 27 Jan 2010 20:27:39 +0100

Conclusions Based on our results, MSX2 plays a pivotal role in the development of IPMN through growth stimulation of tumor cells, and its expression was identified as an independent predictive factor for malignancy of BD-IPMN. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-010-0200-1Authors Kennichi Satoh, Tohoku University Graduate School of Medicine Division of Gastroenterology 1-1 Seiryo-machi, Aobaku Sendai Miyagi 980-8574 JapanShin Hamada, Tohoku University Graduate School of Medicine Division of Gastroenterology 1-1 Seiryo-machi, Aobaku Sendai Miyagi 980-8574 JapanAtsushi Kanno, Tohoku University Graduate School of Medicine Division of Gastroenterology 1-1 Seiryo-machi, Aobaku Sendai Miyagi 980-8574 Ja...

Benign cystic peritoneal mesothelioma incorrectly diagnosed as an ovarian borderline mucinous tumor of intestinal type at transvaginal preoperative ultrasound evaluation

Ultrasound in Obstetrics and Gynecology — Fri, 01 Jan 2010 00:00:00 +0100

(Source: Ultrasound in Obstetrics and Gynecology)

Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance.

Ai Zheng — Thu, 31 Dec 2009 11:48:59 +0100

Conclusion: The expression of OPN and B7-H4 increased in epithelial ovarian cancer, which could be referenced in the diagnosis of ovarian malignant tumors. PMID: 20038306 [PubMed - in process] (Source: Ai Zheng)

Extended central pancreatic resection as an alternative for extended left or extended right resection for appropriate pancreatic neoplasms

Surgery — Fri, 11 Dec 2009 00:00:00 +0100

Conclusion: Extended central pancreatectomy for appropriate pancreatic neoplasms is associated with less peri-operative morbidity and mortality than after extended classic left and extended classic right resection. Long-term local recurrence after extended central pancreatectomy is similar to the recurrence rates after extended classic right and classic left resection. Our results suggest that appropriately selected patients will benefit from extended central pancreatectomy because of the maintenance of endocrine and exocrine function. (Source: Surgery)

Müllerian mucinous borderline tumors - Reply

Human Pathology — Thu, 10 Dec 2009 14:50:31 +0100

We appreciate Dr Rutgers' interest in our recent article on müllerian mucinous borderline tumor (MMBT) . Dr Rutgers added another manuscript demonstrating differential immunophenotype between MMBT and intestinal mucinous borderline tumor (IMBT), using antibodies for CEA, MOv8, and CA19-9 . This finding further substantiates the general conception that IMBT is histogenetically and clinicopathologically different from MMBT. In this context, the current World Health Organization classification in which IMBT and MMBT are classified into a single-category “mucinous tumor” may cause a misunderstanding that IMBT and MMBT are similar tumors for some pathologists. (Source: Human Pathology)

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HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

BMC Cancer — Thu, 10 Dec 2009 00:00:00 +0100

Conclusions: HER2 amplification is relatively common in ovarian mucinous carcinomas (6/33, 18.2%), although not of prognostic significance. Trastuzumab therapy is a treatment option for patients with mucinous carcinoma when the tumor has HER2 amplification and overexpression. (Source: BMC Cancer)

Ovarian Mucinous Cystadenoma of Borderline Malignancy in a Premenarchal Girl

Journal of Pediatric and Adolescent Gynecology — Fri, 06 Nov 2009 00:00:00 +0100

Abstract: Ovarian mucinous cystadenomas are benign epithelial neoplasms that occur most often in the third to sixth decade of life. Ovarian mucinous cystadenoma can be classified into 3 categories (benign, borderline malignancy, malignancy) based on histopathologic evaluation. Premenarchal cases of ovarian mucinous cystadenoma of borderline malignancy are exceedingly rare. To the best of our knowledge, there have been only 4 reported cases of borderline ovarian mucinous cystadenoma prior to 2009. Here we report a 13-year-old premenarchal girl with a giant mass occupying almost the whole of the abdomino-pelvic cavity. (Source: Journal of Pediatric and Adolescent Gynecology)

Müllerian mucinous borderline tumors

Human Pathology — Mon, 26 Oct 2009 00:00:00 +0100

The study by Dr Yasunaga et al delineating immunohistochemical features of müllerian mucinous borderline tumors (MMBTs) compared with other types of low-grade ovarian tumors was of great interest. (Source: Human Pathology)

Bilateral Ovarian Serous Borderline Tumor with a Giant Non-invasive Peritoneal Implant in a Four-Year-Old Girl

Journal of Pediatric and Adolescent Gynecology — Mon, 19 Oct 2009 00:00:00 +0100

We report a case of a 4-year-old premenarchal girl, previously healthy, who presented with two abdominal masses. Laboratory analysis of blood showed elevation of the serum level of the CA-125. Ultrasonographic examination disclosed bilateral cystic ovarian masses. Laparoscopic exploration revealed bilateral ovarian multicystic masses with retro-uterine peritoneal implant. Bilateral salpingo-oophorectomy with implant resection was performed. Histologic findings were consistent with a serous borderline tumors of both ovaries and the peritoneal implant was of the non-invasive type. There is no evidence of recurrence at 3-year follow-up.To our knowledge, there are only four cases of ovarian borderline tumors in premenarchal girls reported in the English literature: three of the mucinous type a...

Breastfeeding and risk of epithelial ovarian cancer

Cancer Causes and Control — Thu, 24 Sep 2009 16:48:11 +0100

Conclusions A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9440-xAuthors Susan J. Jordan, The University of Queensland School of Population Health Public Health Building, Herston Rd Herston, Brisbane 4006 AustraliaVictor Siskind, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaAdèle C Green, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaDavid C. Whiteman, The Queensland Institute of Medical Resea...

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Clinical Significance of Frozen Section Analysis During Resection of Intraductal Papillary Mucinous Neoplasm: Should a Positive Pancreatic Margin for Adenoma or Borderline Lesion Be Resected Additionally?

Journal of the American College of Surgeons — Mon, 21 Sep 2009 23:00:00 +0100

Conclusions: The presence of adenoma or borderline lesion at the pancreatic margin does not always warrant further resection because of the low recurrence rate in the remnant pancreas. Recurrence after intraductal papillary mucinous neoplasm resection is influenced primarily by the presence and extent of invasive cancer rather than the status of the pancreatic margin. (Source: Journal of the American College of Surgeons)

Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney

Virchows Archiv — Wed, 16 Sep 2009 18:50:52 +0100

We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK). The patient was an 82-year-old woman who presented with gross hematuria and recurrent urinary tract infection for years. The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion. Subsequently, she underwent a radical left nephrectomy. Cross-sections of left kidney showed a 4.5 × 3.5 × 1.5 cm ill-defined cystic lesion with mucinous and solid areas. Histologic sections of the lesion showed numerous variable-sized dilated cysts with fibrous, fatty, vascular, and smooth muscle stroma. The cysts were lined by a various types of epithelium, including single layer of flat, cuboidal and mucinous epithel...

Pancreatic neuroendocrine tumors among patients with intraductal papillary mucinous neoplasms: real association or just a coincidence?

JOP — Wed, 09 Sep 2009 21:44:05 +0100

CONCLUSION: IPMN and PNT can coexist. The prevalence of PNT among IPMN patients is low (3.8%). Our study is limited by small sample size. Large studies with large number of patients are needed to further explore this association. PMID: 19734627 [PubMed - in process] (Source: JOP)

[Claudin expression in different pancreatic cancers and its significance in differential diagnostics]

Magyar Onkologia — Tue, 01 Sep 2009 00:00:00 +0100

Authors: Katalin B Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.) In addition to the well-known CLDN-1 and -4 expression CLDN-2, -3 and -7 proteins were demonstrated in ductal cells, while CLDN-3 and -7 proteins show...

Pseudomyxoma peritonei associated with primary mucinous borderline tumor of the renal pelvicalyceal system.

Archives of Pathology and Laboratory Medicine — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Rao P, Pinheiro N, Franco M, Ra S, Costa H, Manzano J, Paner GP, Silva EG, Amin MB Primary mucinous cystic neoplasms are extraordinarily rare tumors of the kidney. Herein, we present a case of a 52-year-old man who presented with painless hematuria and mucusuria. The nephrectomy showed a markedly enlarged kidney replaced by a large cystic mass filled with mucin and with almost complete destruction of the renal parenchyma. Histologically, the mass was lined primarily by simple mucinous epithelium and showed foci of adenomatous (borderline) change with focal areas exhibiting intraepithelial carcinoma. No invasion was documented after extensive sampling of the tumor. A pathologic diagnosis of intraepithelial carcinoma arising in a mucinous neoplasm of borderline malignancy was re...

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[Claudin expression in different pancreatic cancers and its significance in differential diagnostics.]

Magyar Onkologia — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Borka K Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.) In addition to the well-known CLDN-1 and -4 expression CLDN-2, -3 and -7 proteins were demonstrated in ductal cells, while CLDN-3 and -7 proteins showed...

Clinical impact of under-diagnosis by frozen section examination is minimal in borderline ovarian tumors

European Journal of Surgical Oncology — Tue, 11 Aug 2009 10:05:54 +0100

Conclusions: The under-diagnosis by frozen section examination did not compromise the outcome in patients with BOTs, although under-diagnosis was associated with more conservative surgery. (Source: European Journal of Surgical Oncology)

Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.

Pathology, Research and Practice — Sun, 09 Aug 2009 23:00:00 +0100

Authors: Virk R, Lu D Sertoli-Leydig cell tumor (SLCT) is a rare tumor involving the ovary. Approximately 20% of SLCT are associated with heterologous elements that are either of endodermal or mesodermal origin. The gastrointestinal-type epithelium is the most commonly described endodermal heterologous element. SLCT with benign and borderline mucinous neoplasm has been reported in the literature. However, SLCT with mucinous adenocarcinoma as heterologous element has been rarely documented. Herein, we describe a rare case of intermediately differentiated Sertoli-Leydig cell tumor with mucinous adenocarcinoma as the heterologous element in a 21-year-old woman. She presented with throbbing lower abdominal pain and was found to have a large, complex left ovarian mass on imaging studies. Sh...

Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasms: Accuracy of MR Imaging in Differentiation between Benign and Malignant Tumors Compared with Histopathologic Analysis [Gastrointestinal Imaging]

Continuous Publishing articles — Thu, 30 Jul 2009 23:00:00 +0100

Conclusion: Duct wall nodules and enhancement of the MPD walls are signs of malignant MPD or mixed type IPMNs. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2531080604/DC1 © RSNA, 2009 (Source: Continuous Publishing articles)

Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasms: Accuracy of MR Imaging in Differentiation between Benign and Malignant Tumors Compared with Histopathologic Analysis.

Radiology — Thu, 30 Jul 2009 23:00:00 +0100

Conclusion: Duct wall nodules and enhancement of the MPD walls are signs of malignant MPD or mixed type IPMNs. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2531080604/DC1 (c) RSNA, 2009. PMID: 19703865 [PubMed - as supplied by publisher] (Source: Radiology)

Borderline-like Mucinous Tumor Arising in Mature Cystic Teratoma of the Ovary Associated With Pseudomyxoma Peritonei.

International Journal of Gynecological Pathology — Fri, 26 Jun 2009 14:44:44 +0100

Page: 376DOI: 10.1097/PGP.0b013e318191e766Authors: Hwang, Jong Ha MD; So, Kyeong-A MD; Modi, Gayatri MD; Lee, Jae Kwan PhD; Lee, Nak Woo PhD; Lee, Kyu Wan PhD; Kim, Insun PhD (Source: International Journal of Gynecological Pathology)

[Diagnostic problems of ovarian mucinous borderline tumors.]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is good, but they are resistant to the traditional chemotherapies. To diagnose the intraepithelial carcinoma, to detect the microinv...

[Diagnostic problems of ovarian mucinous borderline tumors]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Mucinous cystic neoplasms of the mesentery: a case report and review of the literature

World Journal of Surgical Oncology — Tue, 19 May 2009 04:00:00 +0100

Conclusions: Mucinous cystic neoplasms of the mesentery present almost exclusively in women and must be considered in the differential diagnosis of mesenteric tumors. Only full histological examination of a mucinous cystic neoplasm can exclude a borderline or malignant component. An updated classification of mesenteric cysts and cystic tumors is proposed. (Source: World Journal of Surgical Oncology)

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Clinical fate of branch duct and mixed forms of intraductal papillary mucinous neoplasia of the pancreas

Journal of Gastroenterology and Hepatology — Tue, 19 May 2009 04:00:00 +0100

Conclusion: Patients with the mixed form of IPMN as well as with symptomatic branch duct IPMN should require pancreatic resection because of symptoms and the risk for malignancy. In silent branch duct IPMN without radiological signs of malignancy, a non-operative watch-and-wait strategy can be discussed. (Source: Journal of Gastroenterology and Hepatology)

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumors

Basic and Applied Pathology — Mon, 18 May 2009 04:00:00 +0100

Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)

A unique benign mucinous cystadenoma of the retroperitoneum: a case report and review of the literature

Archives of Gynecology and Obstetrics — Sat, 16 May 2009 05:52:48 +0100

We present here the curious case of a 37-year-old woman with two large, fast growing, cystic, benign, primary retroperitoneal mucinous cystadenomas treated definitively by local resection. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1118-9Authors Elliot B. Tapper, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USAAdam B. Shrewsberry, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USAGabriella Oprea, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USABhagirath Majmudar, Emory University School of Medicine 1293 University Dr Atlanta GA 30306 USA Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors

Pathology International — Tue, 21 Apr 2009 04:00:00 +0100

Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage. The numbers of CD68-positive macrophages as well as of CD163- and CD204-positive...

KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay

BMC Cancer — Thu, 09 Apr 2009 04:00:00 +0100

Conclusions: KRAS mutation is a common event in ovarian cancer primarily in carcinomas of lower grade, lower FIGO stage, and mucinous histotype. The KRAS mutational status is no prognostic factor for patients treated with standard therapy. However, in line with experience from colorectal cancer and non-small-cell-lung cancer (NSCLC), it may be important in predicting response to EGFR-targeted therapies. (Source: BMC Cancer)

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Biliary intraductal papillary mucinous neoplasia: three case reports

Virchows Archiv — Sun, 05 Apr 2009 12:54:41 +0100

We present herein three cases diagnosed with the clinical and pathological findings of a new entity in the literature, b-IPMN, and we discuss the macroscopic, histological, and immunohistochemical features. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00428-009-0767-1Authors Banu Yaman, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyDeniz Nart, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyFunda Yilmaz, University of Ege Department of Pathology, Faculty of Medicine Izmir TurkeyAhmet Coker, University of Ege Department of General Surgery, Faculty of Medicine Izmir TurkeyMurat Zeytunlu, University of Ege Department of General Surgery, Faculty of Medicine Izmir TurkeyMurat Kilic, University of Ege Department of Gen...

Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients.

The British Journal of Surgery — Thu, 12 Mar 2009 04:00:00 +0100

CONCLUSION:: A simple increase in cyst size is not a reliable predictor of malignancy. Observation is recommended for patients with a BD-IPMN smaller than 30 mm showing no suspicious features on imaging. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 19283746 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)

Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients

British Journal of Surgery — Thu, 12 Mar 2009 04:00:00 +0100

This study investigated whether these recommendations could be validated in a single-centre experience of BD-IPMNs.Some 190 patients with radiological imaging or histological findings consistent with BD-IPMN were enrolled between 1998 and 2005. Those with less than 6 months' follow-up and no histological confirmation were excluded.BD-IPMN was diagnosed by computed tomography and pancreatography in 105 patients and pathologically in 85. Eighteen patients had adenoma, 53 borderline malignancy, five carcinoma in situ and nine invasive carcinoma. Findings associated with malignancy were the presence of radiologically suspicious features (P < 0·001) and a cyst size of at least 30 mm (P = 0·001). Had consensus guidelines been applied, 54 patients would have undergone pancreatic resection, wher...

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.

Gynecologic Oncology — Mon, 09 Mar 2009 04:00:00 +0100

CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors

Human Pathology — Mon, 09 Mar 2009 00:00:00 +0100

Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to serous borderline tumor or low-grade endometrioid tumor than to gastrointestinal mucinous borderline tumor by directly co...

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MRI appearances of borderline ovarian tumours.

Clinical Radiology — Sun, 08 Mar 2009 18:36:34 +0100

Authors: Bent CL, Sahdev A, Rockall AG, Singh N, Sohaib SA, Reznek RH This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tumour. A history of a metachronous mucinous borderline tumour was identified in one patient. MRI appea...

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.

Human Pathology — Fri, 06 Mar 2009 05:00:00 +0100

Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to s...

Choroidal eye metastases from (recurrent) primary peritoneal carcinoma: case report and review of the literature

International Seminars in Surgical Oncology — Tue, 20 Jan 2009 05:00:00 +0100

Conclusion: High index of suspicion is warranted when patients with history of primary peritoneal carcinoma present with visual complaints in order to treat and/or relieve symptomatology from metastatic eye disease. (Source: International Seminars in Surgical Oncology)

[Computed tomography of pancreatic tumors.]

Der Radiologe — Sun, 11 Jan 2009 05:00:00 +0100

Authors: Grenacher L, Klauß M Computed tomography (CT) and in particular multi-detector row computed tomography (MDCT), also known as multislice CT (MSCT), is ideally suited for detecting pancreatic tumors because of the high spatial resolution.The method of choice is hydro-CT which involves distension of the stomach and duodenum by administration of 1-1.5 l water as a negative contrast medium under medically induced hypotension by administration of buscopan. The patient is laid on the right side at an angle of 30-45 degrees in order to obtain an artefact-free image of the close anatomical relationship around the pancreas head. In addition, curved MPRs or in rare cases 3D reconstructions could be very helpful in identifying the critical anatomic tumor site in the neighbourhood of ...

Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia.

Histopathology — Thu, 01 Jan 2009 05:00:00 +0100

CONCLUSIONS: There is a close association between SMMN-FGT and LEGH/PGM. Microinvasion and positive peritoneal cytology may not have an influence on outcome. PMID: 19207943 [PubMed - in process] (Source: Histopathology)

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Accuracy of frozen section diagnosis in ovarian masses: experience at a tertiary oncology center

Archives of Gynecology and Obstetrics — Wed, 31 Dec 2008 10:12:30 +0100

Conclusion Frozen section is a reliable method for surgical management of patients with adnexal masses. Gross examination and clinical data are two valuable parts of intraoperative consultation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0899-6Authors Azadeh Rakhshan, Shohada Hospital, Shaheed Beheshti University of Medical Sciences Department of Pathology Tehran IranHanieh Zham, Shohada Hospital, Shaheed Beheshti University of Medical Sciences Department of Pathology Tehran IranMehdi Kazempour, Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Sciences Department of Biostatistics Tehran Iran Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and ...

LIM only 4 is overexpressed in late stage pancreas cancer

Molecular Cancer — Mon, 22 Dec 2008 04:05:41 +0100

Conclusions: Pancreatic carcinomas (both IDC and IPMC) expressed significantly higher levels of LMO4 mRNA than did normal ductal epithelia, PanIN-1B, PanIN-2, IPMA and IPMB. These results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. (Source: Molecular Cancer)

[Differentiated therapy for intraductal papillary mucinous neoplasms.]

Der Chirurg — Fri, 12 Dec 2008 05:00:00 +0100

Authors: Wente MN, Schmied BM, Schmidt J, Büchler MW Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are of increasing interest in the field of pancreatic surgery ever since their first description as an individual pancreatic tumor entity in 1982. The decision for surgical or conservative management is based on the adenoma-carcinoma sequence and the differentiation into main-duct or branch-duct IPMN. Invasive IPMN forms (carcinoma in situ and invasive carcinoma) and in particular noninvasive IPMNs (adenoma and borderline tumors) reveal significantly better survival rates than ductal adenocarcinoma of the pancreas. PMID: 19082569 [PubMed - as supplied by publisher] (Source: Der Chirurg)

Analysis of gene expression in early-stage ovarian cancer.

Clinical Cancer Research — Mon, 01 Dec 2008 05:00:00 +0100

CONCLUSIONS: Specific molecular signatures define different histotypes and prognosis of stage I ovarian cancer. Mucinous and clear cells histotypes can be distinguished from the others regardless of tumor grade. Cyclin E and minichromosome maintenance protein 5, whose expression was found previously to be related to a bad prognosis of advanced ovarian cancer, appear to be potential prognostic markers in stage I ovarian cancer too, independent of other pathologic and clinical variables. PMID: 19047114 [PubMed - in process] (Source: Clinical Cancer Research)

Predictive value of needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening.

Histopathology — Mon, 01 Dec 2008 05:00:00 +0100

Conclusions: Our results show that approximately one-fifth of NCB of screen-detected breast lesions classified as B3 are malignant on excision, and the likelihood of malignancy varies substantially between different histological subtypes. PMID: 19076681 [PubMed - in process] (Source: Histopathology)

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[Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]

Cirugia eEspanola — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, Lladó L, Valls C, Serrano T, Rafecas A Management of the cystic lesions of the pancreas is of interest to general and pancreatic surgeons and physicians of other disciplines: gastroenterology, internal medicine, endoscopy, radiology, pathology, etc. The majority of cystic lesions are inflammatory pseudo-cysts. Cystic neoplasms represents only 10% of cystic lesions of the pancreas and 1% of pancreatic tumours. Preoperative diagnosis is crucial given the differences in natural history of the spectrum of benign, malignant, and borderline lesions. Serous cystadenoma is a benign lesion that requires non-surgical management if there are no symptoms. Mucinous neoplasms are premalignant lesions that mainly require pa...

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.

International Journal of Oncology — Sun, 23 Nov 2008 10:41:33 +0100

In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology. PMID: 19020757 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)

Correlation between CT patterns and pathological classification of intraductal papillary mucinous neoplasm.

European Journal of Radiology — Tue, 11 Nov 2008 05:00:00 +0100

CONCLUSION: The three CT types of IPMN well correlated with the pathologic classification, which is helpful for analyzing CT manifestations and improving the accuracy of diagnosis. MPD dilation is usually larger than CBD dilation in IPMN patients, which is also helpful in the diagnosis and differential diagnosis of IPMN in the context of other related findings. PMID: 19008065 [PubMed - as supplied by publisher] (Source: European Journal of Radiology)

Serous and seromucinous infantile ovarian cystadenomas-A study of 42 cases.

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Fri, 07 Nov 2008 05:00:00 +0100

Authors: Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C The rarity of infantile ovarian cystadenoma (CA) accounts for the very little knowledge about their behaviour. The aim of this retrospective study is to highlight the modes of presentation and to evaluate the treatments and the recurrence risks of these benign tumours. Relation to adult epithelial ovarian tumours is discussed. The medical records and imaging studies of 42 CA in 31 children less than 16 years of age operated at our institution between 1985 and 2003 were retrospectively evaluated. Mean age of first surgery was 11 and 5 years. 7/31 (22, 6%) girls presented with a bilateral CA, four of them were synchronous. 8/42 (19%) CA were in torsion at surgery, conservative management was ...

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors

Basic and Applied Pathology — Tue, 04 Nov 2008 05:00:00 +0100

Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)

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MSCT and MRCP features of intraductal papillary mucinous tumor of the pancreas

The Chinese-German Journal of Clinical Oncology — Sat, 01 Nov 2008 07:00:41 +0100

Conclusion The MSCT and MRCP features of IPMT are somewhat characteristic, and the correct diagnosis can be made with the combination of clinical features. Diameter of branch duct ≥ 3 cm with multiple or large mural nodules, or severe dilated main duct indicates the probability of malignant IPMT. Content Type Journal ArticleDOI 10.1007/s10330-008-0106-zAuthors Bin Yang, Hangzhou First People’s Hospital Department of Radiology Hangzhou 310006 ChinaWenhui Chen, Hangzhou First People’s Hospital Department of Radiology Hangzhou 310006 ChinaXiaofeng Zhang, Hangzhou First People’s Hospital Department of Digestion Hangzhou 310006 ChinaYixin Yu, Hangzhou First People’s Hospital Department of Radiology Hangzhou 310006 ChinaXiao Li, Hangzhou First People’s Hospital ...

Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy.

Histopathology — Sat, 01 Nov 2008 04:00:00 +0100

CONCLUSIONS: The current data provide evidence that decreased expression of GCIP in vivo is present in human breast carcinoma and indicate that GCIP is a potential indicator of good prognosis. In patients receiving neoadjuvant chemotherapy, it may also have predictive value for the chemotherapeutic response. PMID: 18983464 [PubMed - in process] (Source: Histopathology)

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1

Archives of Gynecology and Obstetrics — Tue, 21 Oct 2008 06:12:08 +0100

Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saitama 350-1298 JapanMariko Fujita, Tokai University Department of Pathology, School of Medicine Tokyo JapanTakeshi Hirasawa, Tokai University Department of Obstetrics and Gy...

Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumors

Pathology International — Sat, 11 Oct 2008 06:46:58 +0100

Hepatocyte nuclear factor 4[alpha] (HNF4[alpha]) is a member of the nuclear receptor superfamily and is expressed in several endodermal tissues. The aim of the present study was to examine the expression of HNF4[alpha] on ovarian epithelial tumors with immunocytochemistry and immunohistochemistry using mAbs recognizing P1 and P2 promoter-driven HNF4[alpha]. Ovarian mucinous adenoma, mucinous tumors of borderline malignancy, and mucinous adenocarcinoma had positive nuclear staining for HNF4[alpha] (41/45, 91%). One-third (34%) of mucinous tumors had P1-positive staining and most had P1/P2-positive staining (93%). MUC2- and MUC5AC-positive staining was observed in 34% and 95% of mucinous tumors, respectively. The histological subtype of these mucinous tumors was not correlated with HNF4[alph...

Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual association

Fertility and Sterility — Wed, 01 Oct 2008 04:00:00 +0100

Conclusion(s): Ovarian tumors present in monozygotic twins may not always be of the same histologic type. (Source: Fertility and Sterility)

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Diverse histologic appearances in pulmonary mucinous cystic neoplasia: a case report

Journal of Medical Case Reports — Mon, 29 Sep 2008 04:00:00 +0100

Conclusion: This case highlights the continuous spectrum of pulmonary mucinous cystic neoplasia from benign mucinous cystadenoma to malignant mucinous cystadenocarcinoma, and the probable existence of a 'borderline' mucinous cystic tumor. Although molecular data are lacking to substantiate progression from benign to malignant in these neoplasms, the importance of recognizing the morphologic continuum lies in alerting pathologists to thoroughly examine specimens to rule out invasive foci in tumors with 'borderline' morphology. (Source: Journal of Medical Case Reports)

Loss of heterozygosity on chromosome 17p13.3 in ovarian cancer and cervical cancer

Chinese Journal of Cancer Research — Sun, 28 Sep 2008 18:36:15 +0100

Conclusion: These results show that LOH on 17p13.3 is associated with ovarian cancer and cervical cancer, suggesting that detection of LOH on 17p13.3 may be helpful to understand the molecular pathogenesis of ovarian cancer and cervical cancer. Content Type Journal ArticleDOI 10.1007/BF02962173Authors Guoling Zhang, Shanghai Medical University Department of Gynecology, Shanghai Cancer Hospital 200032 ShanghaiHuijian Yang, Shanghai Medical University Department of Gynecology, Shanghai Cancer Hospital 200032 ShanghaiKaili Xu, Shanghai Cancer Institute 200032 ShanghaiJin Zhou, Shanghai Cancer Institute 200032 ShanghaiRuidi Qin, Shanghai Medical University Department of Gynecology, Shanghai Cancer Hospital 200032 ShanghaiMinghua Lu, Shanghai Cancer Institute 200032 Shanghai Journa...

Laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein: Report of three cases

Surgery Today — Sat, 27 Sep 2008 14:06:09 +0100

Abstract Between March 2003 and March 2007, three patients with benign pancreatic tumors underwent a planned laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein. Four trocars were placed, and an endoscopic linear stapler was used to transect of the pancreas. The perioperative data and surgical outcomes were examined. This procedure was successfully completed in three patients. The mean operative time was 158.3 min, with mean blood loss of 14.7 ml. The postoperative pathological diagnoses included one insulinoma, one solid pseudopapillary tumor, and one intraductal papillary-mucinous adenoma. The mean size of the tumors was 29.3 mm. Oral intake was initiated on day 1.7, and the length of postoperative hospital stay was 8.7 d...

Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison with Patients with Other Pancreatic Cystic Neoplasms

Annals of Surgical Oncology — Thu, 11 Sep 2008 07:04:02 +0100

Conclusion The EPM prevalence of IPMN patients was 33.8%. Advanced age at IPMN diagnosis was the only factor significantly associated with EPMs in our IPMN cohort. In our PCN cohort, advanced age at PCN diagnosis was associated with malignant PCN and IPMN showed a borderline positive association with EPM. Content Type Journal ArticleCategory Hepatobiliary and Pancreatic TumorsDOI 10.1245/s10434-008-0143-4Authors Won Jae Yoon, Seoul National University College of Medicine Division of Gastroenterology, Department of Internal Medicine 28 Yeongon-dong, Jongno-gu Seoul 110-744 KoreaJi Kon Ryu, Seoul National University College of Medicine Division of Gastroenterology, Department of Internal Medicine 28 Yeongon-dong, Jongno-gu Seoul 110-744 KoreaJun Kyu Lee, Seoul National ...

Accuracy of intraoperative frozen section in the diagnosis of ovarian tumors

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Fri, 29 Aug 2008 04:00:00 +0100

Conclusion: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

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Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery

Cancer Causes and Control — Fri, 15 Aug 2008 07:10:36 +0100

Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAJennifer A. Doherty, Fred Hutchinson Cancer Researc...

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference

BioMed Central — Mon, 28 Jul 2008 04:00:00 +0100

The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern regional Cooperative Human Tissue Network (CHTN) and University of Alabama-Birmingham (UAB) Ovarian Spore Center. Thirty-nine mtDNA variants were detected of which 28 were p...

PAPER: Experience With 208 Resections for Intraductal Papillary Mucinous Neoplasm of the Pancreas

Archives of Surgery — Mon, 21 Jul 2008 04:00:00 +0100

Conclusions Patients with main duct IPMN or high-risk branch duct IPMN should be considered for targeted pancreatectomy. Invasive IPMN behaves as aggressively as ductal adenocarcinoma, but resection seems to provide the only potential for cure. Even with negative resection margins, the pancreatic remnant harbors a risk of recurrence and, thus, careful long-term surveillance is warranted. (Source: Archives of Surgery)

Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm.

Clinical Gastroenterology and Hepatology — Tue, 01 Jul 2008 04:00:00 +0100

Conclusions: Implementation of the Consensus Guidelines to our single-institution, referral-based, surgical BD-IPMN population would have recommended resection of all histologically high-risk lesions. All lesions recommended for nonsurgical management were histologically low-risk lesions. For presumed BD-IPMNs less than 3 cm, the application of the Consensus Guidelines may reduce the resection rate for low-risk lesions. PMID: 18602036 [PubMed - in process] (Source: Clinical Gastroenterology and Hepatology)

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.

Cancer Control — Sat, 14 Jun 2008 20:37:38 +0100

We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no associ...

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Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Fertility and Sterility — Thu, 12 Jun 2008 23:00:00 +0100

Conclusion(s): Laparoscopic fertility-sparing staging in early ovarian malignancies is feasible and safe in selected and counseled patients and should be performed in experienced gynecological oncology centers trained in endoscopic procedures. (Source: Fertility and Sterility)

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies.

Fertility and Sterility — Thu, 12 Jun 2008 04:00:00 +0100

CONCLUSION(S): Laparoscopic fertility-sparing staging in early ovarian malignancies is feasible and safe in selected and counseled patients and should be performed in experienced gynecological oncology centers trained in endoscopic procedures. PMID: 18555237 [PubMed - as supplied by publisher] (Source: Fertility and Sterility)

Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas

Virchows Archiv — Sat, 24 May 2008 06:53:19 +0100

Abstract To analyze the expression of matrix metalloproteinases (MMPs) and their relationships with the histological grades of the intraductal papillary mucinous neoplasm (IPMN) of the pancreas, we examined the frequency of expression and intracellular localization of MMP1, MMP2, MMP3, MMP7, and MMP9 in IPMN by immunohistochemistry. A total of 45 IPMN lesions (14 adenomas, 17 borderline lesions, nine noninvasive carcinomas, and five invasive lesions) from 21 patients were examined. MMP1, MMP2, MMP7, and MMP9 were expressed in tumor cells. Frequency of tumor cells expressing MMP7 was low in adenomas (median, 5.0%), higher in borderline lesions (median, 30.0%), in noninvasive carcinomas (median, 50.0%), and in invasive lesions (median, 80.0%), with a significant trend (P &...

A Case of Osteoclast-like Giant Cell Tumor of the Pancreas Associated with Borderline Mucinous Cystic Neoplasm.

Pathology Oncology Research — Wed, 21 May 2008 04:00:00 +0100

Authors: Burkadze G, Turashvili G A 34-year-old, previously healthy female presented with severe acute upper quadrant abdominal pain and an 11-cm cystic mass in the tail of the pancreas. The patient underwent distal pancreatectomy with total gross excision of the mass. Grossly, the mass consisted of a multiloculated cystic lesion measuring 11.7 cm in its greatest dimension. An irregular solid lobulation at the lateral aspect of the cyst was visible, measuring 3 cm in the largest dimension. Histologically, there were two distinct components: a mucinous, neoplastic epithelial cyst with few foci of moderate atypia, and nodular spindle cell areas containing multinucleated tumor giant cells. Immunohistochemically, the multinucleated giant cells were positive for vimentin, CD68 and CD45, and...

Primary retroperitoneal cystic mucinous borderline tumour mimicking an ovarian neoplasm: a case report and literature review

Gynecological Surgery — Tue, 20 May 2008 06:18:15 +0100

We present a case of primary retroperitoneal mucinous tumour of borderline malignancy in a 58-year-old woman, detected as an incidental finding. The patient presented with acute renal failure, investigation for which revealed a complex pelvic mass initially thought to be in the right adnexa and consistent with an ovarian neoplasm. Surgical findings revealed a 130-mm, right-sided non-communicating retroperitoneal pelvic mass, posterior to the appendix, which was completely resected. Both ovaries were normal. Macroscopically, it was a multi-loculated cystic structure with a smooth external surface containing clear and mucinous fluid. Microscopic examination showed a mucinous tumour of borderline malignancy. The literature contains approximately nine other cases of primary mucinous retr...

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Factors influencing the use and accuracy of frozen section diagnosis of epithelial ovarian tumors.

American Journal of Obstetrics and Gynecology — Thu, 15 May 2008 04:00:00 +0100

CONCLUSION: FSD is less accurate for borderline than benign and malignant ovarian tumors. The pathologist's experience is a major determinant of diagnostic accuracy. PMID: 18486086 [PubMed - as supplied by publisher] (Source: American Journal of Obstetrics and Gynecology)

[Maternal virilization due to mucinous ovarian tumour: A case report.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Mon, 05 May 2008 04:00:00 +0100

We present a rare case of a virilizating borderline mucinous ovarian tumour on a gravida 1 patient. The tumour was responsible for a clinical hyperandrogenism and for an increased testosteronemia. This patient was treated by ovariectomy at 31 weeks of gestation. The surgery was completed one month after delivery. There was no fetal consequence and the clinical and biological signs of virilization totally disappeared after surgery. PMID: 18462892 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Body size and risk of epithelial ovarian and related cancers: A population-based case-control study

International Journal of Cancer — Wed, 30 Apr 2008 04:00:00 +0100

Alterations in Mucin Expression in Ovarian Mucinous Tumors: Immunohistochemical Analysis of MUC2, MUC5AC, MUC6, and CD10 Expression.

Acta Histochemica et Cytochemica — Sat, 26 Apr 2008 04:00:00 +0100

Authors: Hirabayashi K, Yasuda M, Kajiwara H, Itoh J, Miyazawa M, Hirasawa T, Muramatsu T, Murakami M, Mikami M, Osamura RY The aim of this study was to evaluate the immunohistochemical expression of MUC2, MUC5AC, MUC6, and CD10 in ovarian mucinous adenoma (MA), mucinous borderline tumor (MB), and mucinous adenocarcinoma (MC), and to analyze the relationship between prognosis and these expressions. The expression of MUC2, MUC5AC, MUC6, and CD10 was evaluated by immunohistochemical analysis in 29 cases of MA, 29 cases of MB, and 26 cases of MC and scored based on the percentage of positive cells. Moreover, the ovarian mucinous tumors were classified into 4 phenotypes based on the staining patterns: intestinal, gastrointestinal, gastric, and unclassified patterns. The gastrointestinal pa...

Laparoscopy-assisted cystectomy for large adnexal cysts

Archives of Gynecology and Obstetrics — Wed, 23 Apr 2008 16:16:55 +0100

Conclusion Laparoscopy-assisted surgery is feasible and safe for women with large benign adnexal cysts and result s in a short surgery time. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0651-2Authors Ahmet Göçmen, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyTuba Atak, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyMustafa Uçar, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyFatih Şanlıkal, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul Turkey Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Sour...

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Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas

Journal of Hepato-Biliary-Pancreatic Surgery — Sun, 06 Apr 2008 07:00:03 +0100

Conclusions Duodenum-preserving total pancreatic head resection for IPMN, MCN, serous cystadenoma (SCA), and cystic EN lesions is a safe and beneficial surgical procedure. Segmental resection of the duodenum was applied for an oncologically complete resection. In regard to long-term outcome, the procedure is, additionally, a pancreatic cancer preventive strategy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00534-007-1227-4Authors Hans G. Beger, c/o Universitätsklinikum Ulm Steinhövelstrasse 9 D-89075 Ulm GermanyFrank Gansauge, Department of Visceral Surgery Donau-Klinik Neu-Ulm GermanyMarko Siech, Department of General-, Vascular-and Visceral Surgery Ostalb Klinikum Aalen GermanyMichael Schwarz, Department of Visceral Surgery Donau-Klinik Neu-U...

Removal of enormous bilateral mucinous cystadenomas of the ovaries with abdominal plastic reconstruction

Archives of Gynecology and Obstetrics — Thu, 03 Apr 2008 08:25:39 +0100

Discussion Huge intraabdominal tumors that almost double a patient’s body weight can hardly be malign. Total tumor excision is necessary because the heterogeneous composition requires careful examination by pathologists to rule out borderline tumors and non-invasive carcinomas. After tumor excision an abdominal wall reconstruction might be necessary because of the laxity and redundancy of the skin. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0634-3Authors Andreas Hackethal, Justus-Liebig-University of Giessen Department of Obstetrics and Gynecology Klinikstrasse 32 35385 Giessen GermanyDoerthe Brueggmann, Justus-Liebig-University of Giessen Department of Obstetrics and Gynecology Klinikstrasse 32 35385 Giessen GermanyMaxim Turovets, Justu...

Pancreas - Biopsy of IPMN Nodule by Direct Pancreatoscopy

The Digital Atlas of Video Education - Gastroenterology — Wed, 02 Apr 2008 15:04:03 +0100

A 36 year old woman was referred to the Massachusetts General Hospital for evaluation of an incidental pancreatic cystic lesion found on abdominal ultrasound. An abdominal CT confirmed the finding, demonstrating a 5 cm multi-cystic lesion in the pancreatic head, with diffuse dilation of the pancreatic duct in the body and tail. ERCP and EUS performed at an outside institution were non-diagnostic. However, the EUS at the outside hospital demonstrated an intramural nodule, raising concern for malignancy, and thus warranting further evaluation. The patient was subsequently seen at the MGH. Endoscopic evaluation demonstrated a patulous ampulla. A pancreatogram was obtained and demonstrated a large, cystic dilation of the pancreatic duct in the head. Aspiration of 10 cc of pancreatic duct fluid...

Immunohistochemical Analysis of Reserve Cell-Like Cells of Ovarian Mullerian Mucinous/Mixed Epithelial Borderline Tumor.

International Journal of Gynecological Pathology — Fri, 21 Mar 2008 07:59:30 +0100

Page: 199DOI: 10.1097/PGP.0b013e31815b077bAuthors: Hamada, Tomomi M.D.; Kiyokawa, Takako M.D.; Nomura, Kouichi M.D.; Hano, Hiroshi M.D. (Source: International Journal of Gynecological Pathology)

Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms.

Gynecologic Oncology — Sat, 08 Mar 2008 05:00:00 +0100

CONCLUSIONS: CEACAM6 is overexpressed in borderline and invasive MON's. PMID: 18331757 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Human papilloma virus (HPV) status, p16(INK4a), and p53 overexpression in epithelial malignant and borderline ovarian neoplasms.

Pathology, Research and Practice — Mon, 25 Feb 2008 10:06:14 +0100

Authors: Giordano G, Azzoni C, D'Adda T, Rocco A, Gnetti L, Froio E, Merisio C, Melpignano M This investigation is the first to evaluate simultaneously human papilloma virus (HPV) status, p16(INK4a), and p53 immunoreactivity in epithelial ovarian neoplasms. The results were analyzed and correlated with histological type, histological grade, and survival of patients. Subtypes considered are papillary serous and mucinous. Polymerase chain reaction (PCR) analysis, performed in our previous study, had already demonstrated a small number of HPV-positive epithelial ovarian neoplasms. No significant correlation was found between the presence of HPV DNA and subtypes of ovarian neoplasms; thus, HPV cannot be considered responsible for epithelial ovarian neoplasm. Since p16 immunoreactivity was ...

Morphologic Changes in Branch Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Midterm Follow-Up Study.

Clinical Gastroenterology and Hepatology — Mon, 25 Feb 2008 05:00:00 +0100

CONCLUSIONS: In patients with IPMNs confined to BD, morphologic changes are rare events, justifying a nonsurgical approach. Careful follow-up evaluation remains necessary, particularly in patients with an increase in BD size. PMID: 18304885 [PubMed - as supplied by publisher] (Source: Clinical Gastroenterology and Hepatology)

[Pancreatic cancer] Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results

Gut — Mon, 11 Feb 2008 05:00:00 +0100

Conclusions: Most branch duct IPMNs without mural nodules remained unchanged during long-term follow-up. Although follow-up with careful examination is required to detect newly developed mural nodules in dilated branch ducts, branch duct IPMNs without mural nodules can be followed-up without surgery. (Source: Gut)

Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual association.

Fertility and Sterility — Tue, 05 Feb 2008 05:00:00 +0100

CONCLUSION(S): Ovarian tumors present in monozygotic twins may not always be of the same histologic type. PMID: 18258232 [PubMed - as supplied by publisher] (Source: Fertility and Sterility)

Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: Report of a case and a review of the literature.

World Journal of Gastroenterology — Mon, 07 Jan 2008 05:00:00 +0100

Authors: Hakamada K, Miura T, Kimura A, Nara M, Toyoki Y, Narumi S, Sasak M Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis. We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female. A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000. She refused surgery first and delivered her baby uneventfully. During her second pregnancy in 2002, however, she presented hematemesis and underwent urgent distal pancreatectomy, splenectomy and partial resection of the gastric wall where the tumor perforated. A diagnosis of borderli...

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[Clinicopathologic review of 41 cases of pancreatic mucinous cystic neoplasms.]

Korean J Gastroenter... — Tue, 01 Jan 2008 05:00:00 +0100

Conclusions: Clinical predictors of invasive mucinous cystic neoplasms are suggested to be tumor size and abdominal pain. The prognosis of the non-invasive mucinous cystic neoplasms is excellent when curative resection is performed. PMID: 18349560 [PubMed - in process] (Source: Korean J Gastroenter...)

Natural History of Intraductal Papillary Mucinous Neoplasms (IPMN): Current Evidence and Implications for Management

Journal of Gastrointestinal Surgery — Fri, 21 Dec 2007 16:09:35 +0100

Abstract Intraductal papillary mucinous neoplasms (IPMNs) show varying degrees of dysplasia throughout the neoplasm that can range from adenoma to invasive carcinoma, with dysplastic changes of borderline neoplasms and carcinoma in situ in between. An understanding of the natural history, and especially the required time to transform into either carcinoma in situ or an invasive adenocarcinoma, is critically important for management policy. This topic serves as the rationale for the present analysis. At the beginning of February 2007, using the key word “IPMN” in PubMed, we initially selected 119 publications using the principal criteria as defined by the WHO classification. We identified 20 appropriate original reports and one consensus paper. Neither randomized contro...

Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-alpha.

Acta Histochemica — Sat, 01 Dec 2007 05:00:00 +0100

In this study, we compared the immunoreactivities of TGF-alpha and EGF-R in ovarian tumors and related immunohistochemical findings to the histological type of the tumors. Formalin-fixed, paraffin wax-embedded tissue sections from 40 patients who had serous-mucinous borderline tumor and serous-mucinous adenocarcinoma of the ovary (n=10 each) were stained with hematoxylin-eosin and labeled for binding of primary antibodies against TGF-alpha and EGF-R using an avidin-biotin-peroxidase method. A semi-quantitative grading system was used to compare immunohistochemical labeling intensities. Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-alpha was detected in adenocarcinomas. There was no significant difference in the immunoreactivity of TGF-alpha among the histologic t...

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinicopathologic Characteristics and Long-Term Follow-Up After Resection

World Journal of Surgery — Tue, 20 Nov 2007 15:33:39 +0100

Conclusions Resection of all main duct IPMNs seems to be reasonable. Invasive IPMNs were associated with significantly worse survival than noninvasive IPMNs. Although the diameter of cystic lesions was a predictor of malignancy for branch duct and mixed-type IPMNs, precise preoperative identification of malignancy was difficult. Therefore, these lesions should be managed by aggressive resection before invasion occurs to improve survival. Content Type Journal ArticleDOI 10.1007/s00268-007-9281-2Authors Kazuyuki Nagai, Kyoto University Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery 54 Shogoinkawaracho Sakyo Kyoto 606-8507 JapanRyuichiro Doi, Kyoto University Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Dep...