MedWorm: Borderline Serous Tumor

Serous borderline tumor of the fallopian tube presented as an adnexal mass

Archives of Gynecology and Obstetrics — Mon, 15 Mar 2010 17:54:49 +0100

Conclusion Serous borderline tumors of the fallopian tube are diagnosed in the third-fourth decade and are usually discovered incidentally during routine gynecologic examination or during an elective surgery. To date, there are no reports in the literature regarding recurrence or metastatic disease of STLMP of the fallopian tube. Conservative fertility-sparing surgery proved to be a safe and equally effective treatment for patients who wished to preserve their childbearing potential. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1410-8Authors Rita Abreu, Coimbra University Hospital Gynecology Department Praceta Dr. Mota Pinto 3000-075 Coimbra PortugalMarylin Dick, Aveiro District Hospital Gynecology Department Aveiro PortugalTeresa...

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Inherited Determinants of Ovarian Cancer Survival.

Clinical Cancer Research — Tue, 26 Jan 2010 00:00:00 +0100

CONCLUSION: An extensive multiple-pathway assessment found evidence that inherited differences may play a role in outcome of ovarian cancer patients, particularly in genes within the angiogenesis and inflammation pathways. Our work supports efforts to target such mediators for therapeutic gain. Clin Cancer Res; 16(3); 995-1007. PMID: 20103664 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Biomolecular Pathogenesis of Borderline Ovarian Tumors: Focusing Target Discovery Through Proteogenomics.

Current Cancer Drug Targets — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Vergara D, Tinelli A, Martignago R, Malvasi A, Leo G Tumors of the epithelial surface account for about 80% of all ovarian neoplasms and exhibit a heterogeneous histological classification affecting survival. Tumors of low malignant potential, defined as borderline ovarian tumors (BOTs), have a markedly better survival and low recurrence, even if surgery still represents the common management for this type of cancer. It is still debated in the literature if BOTs can be considered as intermediate precursors in the progression to high grade ovarian tumors. Evidences now propose that high-grade serous carcinomas are not associated with a defined precursor lesion. Together with histopathological studies, mutations of KRAS, BRAF and p53 genes, microsatellite instability (MSI) and u...

Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance

Journal of Pediatric Surgery — Thu, 31 Dec 2009 15:18:28 +0100

Conclusion: By combining our series with 13 in the literature, a 1.8% malignancy rate occurred in 707 patients with ovarian torsion, markedly less than the reported malignancy rate of 10% in children with ovarian masses. Thus, neither a pathologic nor malignant lead point should be assumed in cases of torsion. In our series, which represents the largest series of torsion in the pediatric literature, all malignancies presented as stage I. These data further support the implementation of operative detorsion and close postoperative ovarian surveillance, with reoperation for persistent masses. Further study is needed to determine if delaying resection by weeks in those cases of persistent masses would result in tumor progression and thus change prognosis. (Source: Journal of Pediatric Surgery)

Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance.

Ai Zheng — Thu, 31 Dec 2009 11:48:59 +0100

Conclusion: The expression of OPN and B7-H4 increased in epithelial ovarian cancer, which could be referenced in the diagnosis of ovarian malignant tumors. PMID: 20038306 [PubMed - in process] (Source: Ai Zheng)

Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary

Annals of Oncology — Thu, 17 Dec 2009 12:55:12 +0100

Conclusions: This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of advanced-stage borderline ovarian tumors (with noninvasive implants) but the recurrence rate is high. Nevertheless, this high rate has no impact on survival. Conservative surgery can be proposed to patients with a borderline tumor of the ovary and noninvasive peritoneal implants. Should infertility persist following treatment of the borderline tumor, an in vitro fertilization procedure can be cautiously proposed. (Source: Annals of Oncology)

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Recreational physical activity and risk of epithelial ovarian cancer

Cancer Causes and Control — Tue, 01 Dec 2009 21:02:38 +0100

Conclusions Our findings are compatible with an overall reduction in risk of invasive epithelial ovarian cancer associated with recreational activity but suggest that this association may differ in women with different histologic types of disease. Inconsistent findings across studies that have considered histologic type indicate that this issue is not yet resolved. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9479-8Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in E...

Nonpapillary Serous Cystadenoma of the Epididymis: Report of 2 Cases of a Rare Entity

Urology — Wed, 25 Nov 2009 00:00:00 +0100

Testicular and paratesticular tumors of the ovarian epithelial type have been well described in the published data. Since the seminal work by Young and Scully on 14 cases, several short series or isolated cases have been reported. All these tumors have been characterized by a benign indolent biological behavior, despite there also being cases of borderline and even malignant lesions of this type. Most reported cases have shown histopathologic features reminiscent of serous epithelial ovarian cystadenoma with papillary infoldings and nuclear stratification. In 2005, Pich and Galliano reported the first case of cystadenoma of the epididymis unassociated with any papillary growth, similar to some nonpapillary ovarian serous tumors. To the best of our knowledge, since this first report, only 2...

Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma

Human Pathology — Mon, 09 Nov 2009 00:00:00 +0100

Summary: Ovarian serous borderline tumor, micropapillary serous borderline tumor, and low-grade serous carcinoma often show a spectrum of histologic components with increasing epithelial proliferation and papillary complexity from flat cyst wall, hierarchical structures (with primary papillae branching into secondary papillae), micropapillae, and invasive carcinoma. Although tremendous research has been carried out to elucidate the causes of these tumors, the pathogenesis remains unclear. Literature has described a relationship between insufficient selenium intake and increased risk of cancer. The anticancer action of selenium has been suggested to be mediated by selenium-binding protein 1 as selenium-binding protein 1 is decreased in several cancers. The aim of the study was to examine by...

Bilateral Ovarian Serous Borderline Tumor with a Giant Non-invasive Peritoneal Implant in a Four-Year-Old Girl

Journal of Pediatric and Adolescent Gynecology — Mon, 19 Oct 2009 00:00:00 +0100

We report a case of a 4-year-old premenarchal girl, previously healthy, who presented with two abdominal masses. Laboratory analysis of blood showed elevation of the serum level of the CA-125. Ultrasonographic examination disclosed bilateral cystic ovarian masses. Laparoscopic exploration revealed bilateral ovarian multicystic masses with retro-uterine peritoneal implant. Bilateral salpingo-oophorectomy with implant resection was performed. Histologic findings were consistent with a serous borderline tumors of both ovaries and the peritoneal implant was of the non-invasive type. There is no evidence of recurrence at 3-year follow-up.To our knowledge, there are only four cases of ovarian borderline tumors in premenarchal girls reported in the English literature: three of the mucinous type a...

Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathology

Diagnostic Histopathology — Mon, 12 Oct 2009 00:00:00 +0100

Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are also reported. In recent years, serous tubal intraepithelial carcinoma and transitional metaplasia, its mimick, are identified at the fimbria of prophylactic salpingo-ooph...

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[Peritoneal serous borderline tumor discovered during a cesarean section. A case report.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Thu, 08 Oct 2009 23:00:00 +0100

Authors: Raiga J, Ben Abdelkrim S, Dupré F, Treisser A During a caesarean section performed in a 36-year-old woman, we discovered small granulations on the pelvic peritoneum. Biopsies were performed. The diagnosis of primitive borderline serous tumor was confirmed by pathologists. The patient was operated twice: once for diagnostic evaluation, and again six months later. A radical gesture was then decided for therapeutic purposes. The optimal attitude regarding these borderline peritoneal tumors in young women remains difficult and requires a multidisciplinary workout between pathologists and surgeons. PMID: 19819645 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Breastfeeding and risk of epithelial ovarian cancer

Cancer Causes and Control — Thu, 24 Sep 2009 16:48:11 +0100

Conclusions A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9440-xAuthors Susan J. Jordan, The University of Queensland School of Population Health Public Health Building, Herston Rd Herston, Brisbane 4006 AustraliaVictor Siskind, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaAdèle C Green, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaDavid C. Whiteman, The Queensland Institute of Medical Resea...

Conservative resection for benign tumors of the proximal pancreas.

World Journal of Gastroenterology : WJG — Thu, 27 Aug 2009 23:00:00 +0100

CONCLUSION: CR is a safe and effective procedure for patients with benign tumors in the proximal pancreas, with careful CCI-PJ and postoperative MCCL. PMID: 19705501 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic Problems

Advances in Anatomic Pathology — Wed, 26 Aug 2009 12:37:27 +0100

Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors are indolent and have better outcome than high-grade tumors. In contrast, high-grade serous carcinomas have high-grade nuclei and numerous mitotic figures. Identification...

Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary.

Ann Oncol — Wed, 15 Jul 2009 23:00:00 +0100

CONCLUSIONS: This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of advanced-stage borderline ovarian tumors (with noninvasive implants) but the recurrence rate is high. Nevertheless, this high rate has no impact on survival. Conservative surgery can be proposed to patients with a borderline tumor of the ovary and noninvasive peritoneal implants. Should infertility persist following treatment of the borderline tumor, an in vitro fertilization procedure can be cautiously proposed. PMID: 19608617 [PubMed - as supplied by publisher] (Source: Ann Oncol)

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Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review

Archives of Gynecology and Obstetrics — Tue, 14 Jul 2009 09:56:47 +0100

Conclusion The existence of sarcomatous nodules combined with the SLMN necessitates a careful histologic analysis for treatment and the determination of prognosis. However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1180-3Authors Tayfun Gungor, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gynecologic Oncology Department Ankara TurkeyS. Ozlem Altınkaya, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gynecologic Oncology Department Ankara TurkeySerap Akbay, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Pathology Department Ankara TurkeyUmıt Bı...

Clinicopathological significance of DEK overexpression in serous ovarian tumors

Pathology International — Sun, 21 Jun 2009 23:00:00 +0100

To investigate the significance of DEK protein expression in ovarian lesions, a total of 113 ovarian serous tumors, including 62 serous cystadenocarcinomas and 19 serous borderline tumors, were studied on immunohistochemistry. For comparison, 32 benign serous tumors, including 12 serous papillary cystadenomas, 10 serous cystadenomas, and 10 serous surface papillomas, were also included. DEK was positive in 93.5% of serous cystadenocarcinomas (58/62), 63.2% of serous borderline tumors (12/19), and weakly positive in 15.6% of benign serous tumors (5/32). The strong positive signal was detected only in serous adenocarcinomas (80.6%, 50/62) and borderline tumors (21.1%, 4/19), but no serous benign tumors were strongly positive (0%, 0/32). Meanwhile, the strong positivity rate of DEK protein wa...

The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia.

International Journal of Oncology — Sun, 31 May 2009 23:00:00 +0100

This study investigated the expression patterns of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor (MIS/AMHRII) and mRNA in various types of ovarian neoplasia and evaluated the clinical significance of MIS/AMH as a biological response modifier for MIS/AMHR-positive tumors. Reverse transcriptase polymerase chain reaction was used to detect MIS/AMHRII mRNA expression and in situ hybridization and immunohistochemistry were used to localize MIS/AMHRII mRNA and protein expression. The degree of expression was scored from 0 (no staining) to 3 (strong staining). There was no significant difference in expression intensity between MIS/AMHRII protein and mRNA on all ovarian samples whether benign or malignant. MIS/AMHRII protein and mRNA were weakly expressed on 45.4...

Prognostic factors in patients with ovarian serous low malignant potential (borderline) tumors with peritoneal implants.

The Oncologist — Sun, 31 May 2009 23:00:00 +0100

The objective of this study was to determine prognostic factors in a large series of patients with stage II or III serous low malignant potential ovarian tumor (LMPOT) and peritoneal implants. Methods. Patients with a serous LMPOT and peritoneal implants treated at or referred to our institution were retrospectively reviewed. The slides of ovarian tumors and peritoneal implants were reviewed by the same pathologist. Results. From 1969 to 2006, 168 patients were reviewed, 21 of whom had invasive implants. Tumors exhibited a micropapillary pattern in 56 patients. Adjuvant treatment had been administered to 61 patients. The median duration of follow-up was 57 months (range, 1-437). Forty-four patients had relapsed and 10 patients had died. The 5-year overall survival rate was 98%. Among patie...

[Diagnostic problems of ovarian mucinous borderline tumors.]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is good, but they are resistant to the traditional chemotherapies. To diagnose the intraepithelial carcinoma, to detect the microinv...

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[Diagnostic problems of ovarian mucinous borderline tumors]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumors

Basic and Applied Pathology — Mon, 18 May 2009 04:00:00 +0100

Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)

Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

BMC Cancer — Tue, 12 May 2009 04:00:00 +0100

Conclusion: The results indicate that in serous epithelial ovarian malignancies HAS expression is not consistently elevated but HYAL1 expression is significantly reduced and correlates with the accumulation of hyaluronan. (Source: BMC Cancer)

Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas—an image cytometric DNA ploidy analysis of 307 cases with histogenetic implications

Virchows Archiv — Thu, 07 May 2009 05:53:38 +0100

Abstract Our objective was to study the gross genomic alterations in serous borderline tumors and serous adenocarcinomas of the ovary. A retrospective analysis of 245 serous borderline tumors and 62 serous adenocarcinomas from 249 patients was performed using high-resolution image cytometric DNA ploidy analysis. DNA ploidy status, S-phase fraction, and DNA index were evaluated. The majority of serous borderline tumors were diploid (225/245 cases, 92%). The remaining 8% showed an aneuploid peak predominantly with DNA index of less than 1.4. Grades 2 and 3 serous adenocarcinomas were more often (80%) nondiploid, mostly with DNA index exceeding 1.4. Grade 1 serous adenocarcinomas were an intermediate group, more similar to serous borderline tumors. The S-phase fraction increa...

Results after conservative treatment of serous borderline tumours of the ovary with stromal microinvasion but without micropapillary pattern.

BJOG : An International Journal of Obstetrics and Gynaecology — Thu, 30 Apr 2009 23:00:00 +0100

This study suggests that conservative treatment of SBOT-SMI is safe. PMID: 19432576 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

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Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-Grade and High-Grade Carcinomas

Cancer Research — Thu, 30 Apr 2009 04:00:00 +0100

Ovarian serous carcinoma, the most common and lethal type of ovarian cancer, is thought to develop from two distinct molecular pathways. High-grade (HG) serous carcinomas contain frequent TP53 mutations, whereas low-grade (LG) carcinomas arise from serous borderline tumors (SBT) and harbor mutations in KRAS/BRAF/ERBB2 pathway. However, the molecular alterations involved in the progression from SBT to LG carcinoma remain unknown. In addition, the extent of deletion of tumor suppressors in ovarian serous carcinomas has not been well studied. To further address these two issues, we assessed DNA copy number changes among affinity-purified tumor cells from 37 ovarian serous neoplasms including SBT, LG, and HG tumors using high-density 250K single nucleotide polymorphism arrays. Chromosomal inst...

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors

Pathology International — Tue, 21 Apr 2009 04:00:00 +0100

Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage. The numbers of CD68-positive macrophages as well as of CD163- and CD204-positive...

Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms

Human Pathology — Tue, 14 Apr 2009 23:00:00 +0100

In conclusion, hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms because (1) clear cell carcinoma and serous borderline tumor do not coexist and (2) hobnail-like cells in clear cell carcinoma and serous borderline tumor are immunophenotypically distinct. Recognition of our conclusion may protect a patient with “conspicuous hobnail-like cells in serous borderline tumor” from an erroneous overdiagnosis of “concomitant clear cell carcinoma admixed with serous borderline tumor.” (Source: Human Pathology)

Occurrence of Two Rare Malignant Neoplasms (Breast and Ovarian) in an Adolescent Female

Journal of Pediatric and Adolescent Gynecology — Wed, 08 Apr 2009 23:00:00 +0100

Abstract: Background: Phyllodes breast tumors, particularly malignant ones, are rare in adolescents. Tumor behavior does not correlate with histopathology. This case of an adolescent with a malignant phyllodes tumor, followed by the occurrence of a borderline ovarian tumor, also uncommon in adolescence, may shed light on our understanding of phyllodes and uncommon gynecologic malignancies in the young.Case: A-14 year-old Caucasian female underwent wide local excision of a 4-cm malignant phyllodes breast tumor. At 17 years of age she had excision of a serous borderline tumor of the ovary.Comments: The occurrence of two rare neoplasms in an adolescent female raises questions about a common underlying etiology, such as a genetic mutation. Genetic evaluation of minors is a sensitive and comple...

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.

Gynecologic Oncology — Mon, 09 Mar 2009 04:00:00 +0100

CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors

Human Pathology — Mon, 09 Mar 2009 00:00:00 +0100

Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to serous borderline tumor or low-grade endometrioid tumor than to gastrointestinal mucinous borderline tumor by directly co...

MRI appearances of borderline ovarian tumours.

Clinical Radiology — Sun, 08 Mar 2009 18:36:34 +0100

Authors: Bent CL, Sahdev A, Rockall AG, Singh N, Sohaib SA, Reznek RH This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tumour. A history of a metachronous mucinous borderline tumour was identified in one patient. MRI appea...

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.

Human Pathology — Fri, 06 Mar 2009 05:00:00 +0100

Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to s...

[Diagnostic difficulties of serous borderline tumors of the ovary.]

Magyar Onkologia — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential). They represent a common diagnostic and treatment problem both for the pathologist and for clinicians. The borderline tumors occur most commonly in childbearing age, show an indolent course and have good prognosis but are resistant to the traditional chemotherapies. The serous borderline tumors are the most common types of borderline ovarian tumors and they can cause differential diagnostic problems even for the experienced pathologist. We studied 30 cases which were diagnosed in our institute from 2000 to 2008. Thirteen were typical serous borderline tumors, in 7 cases the pattern was micropapillary, in 2 cases with...

Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients.

Gynecologic Oncology — Mon, 02 Feb 2009 05:00:00 +0100

CONCLUSIONS: Maspin is upregulated in borderline tumors and the early stages of ovarian carcinoma and then significantly downregulated with malignant transformation. High expression may paradoxically promote the invasion and metastasis of ovarian carcinomas. Our study revealed that maspin expression could play an important role in predicting the results of treatment of ovarian cancer patients. PMID: 19193429 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Paratubal borderline serous tumors.

Gynecologic Oncology — Sun, 01 Feb 2009 05:00:00 +0100

CONCLUSION: Borderline fallopian tube or paratubal tumors are usually early stage at diagnosis and commonly present in the third decade with pain or are discovered on routine examination. Continued reporting of these tumors is essential to understanding the prognosis and treatment of this rare tumor. PMID: 19189870 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases

Archives of Gynecology and Obstetrics — Fri, 19 Dec 2008 08:15:15 +0100

We present a case of 45-year-old woman with ovarian psammocarcinoma who initially presented with a metastatic subcutaneous nodule, and was found to have pulmonary and mediastinal metastases. We believe this to be the first report of a psammocarcinoma with these metastases. Ovarian and peritoneal psammocarcinomas are quite rare, and because of this, knowledge of their behavior is limited. Although most seem to follow an indolent course similar to that of borderline lesions of the ovary, this case demonstrates that some of these tumors may be clinically aggressive with distant metastases. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0883-1Authors Daniel M. Chase, Western Reserve Care System/Northeast Ohio Universities College of Medicine Department of Surge...

[Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]

Cirugia eEspanola — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, Lladó L, Valls C, Serrano T, Rafecas A Management of the cystic lesions of the pancreas is of interest to general and pancreatic surgeons and physicians of other disciplines: gastroenterology, internal medicine, endoscopy, radiology, pathology, etc. The majority of cystic lesions are inflammatory pseudo-cysts. Cystic neoplasms represents only 10% of cystic lesions of the pancreas and 1% of pancreatic tumours. Preoperative diagnosis is crucial given the differences in natural history of the spectrum of benign, malignant, and borderline lesions. Serous cystadenoma is a benign lesion that requires non-surgical management if there are no symptoms. Mucinous neoplasms are premalignant lesions that mainly require pa...

Immunohistochemical profiling of benign, low malignant potential and low grade serous epithelial ovarian tumors

BMC Cancer — Wed, 26 Nov 2008 05:00:00 +0100

Conclusions: This study represents an extensive analyse of the benign and highly differentiated ovarian disease from an immunohistochemical perspective. (Source: BMC Cancer)

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.

International Journal of Oncology — Sun, 23 Nov 2008 10:41:33 +0100

In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology. PMID: 19020757 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)

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Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study

BMC Cancer — Sun, 16 Nov 2008 05:00:00 +0100

Conclusion: Our report confirms the prognostic value of HIF-1a when restricted to poorly differentiated serous ovarian carcinoma. In addition it shows that this association is elusive, since it is not only methodology-related but it can be antibody-depended. There is adequate evidence to speculate that targeting HIF-1a could improve the long-term prognosis of these patients In order to increase the overall sensitivity of the immunoassay, maintaining acceptable levels of specificity, a panel of antibodies should be used. (Source: BMC Cancer)

Serous and seromucinous infantile ovarian cystadenomas-A study of 42 cases.

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Fri, 07 Nov 2008 05:00:00 +0100

Authors: Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C The rarity of infantile ovarian cystadenoma (CA) accounts for the very little knowledge about their behaviour. The aim of this retrospective study is to highlight the modes of presentation and to evaluate the treatments and the recurrence risks of these benign tumours. Relation to adult epithelial ovarian tumours is discussed. The medical records and imaging studies of 42 CA in 31 children less than 16 years of age operated at our institution between 1985 and 2003 were retrospectively evaluated. Mean age of first surgery was 11 and 5 years. 7/31 (22, 6%) girls presented with a bilateral CA, four of them were synchronous. 8/42 (19%) CA were in torsion at surgery, conservative management was ...

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors

Basic and Applied Pathology — Tue, 04 Nov 2008 05:00:00 +0100

Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)

Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer.

International Journal of Oncology — Sun, 26 Oct 2008 12:12:05 +0100

Authors: Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We investigated nm23-H1, AKT and pAKT expression by using immunohistochemical staining in ovarian clear cell adenocarcinoma, ovarian benign, borderline and malignant serous tumors and analyzed their relationship with prognostic factors. Using ES-2 and SKOV-3 ovarian cancer cell lines, we studied the modulation of estrogen and progestin on cell migration and invasion as well as their effect on AK...

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1

Archives of Gynecology and Obstetrics — Tue, 21 Oct 2008 06:12:08 +0100

Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saitama 350-1298 JapanMariko Fujita, Tokai University Department of Pathology, School of Medicine Tokyo JapanTakeshi Hirasawa, Tokai University Department of Obstetrics and Gy...

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RUNX3 protein is overexpressed in human epithelial ovarian cancer.

Gynecologic Oncology — Sat, 18 Oct 2008 04:00:00 +0100

CONCLUSION: These results suggest that RUNX3 has a role in cell proliferation and viability in ovarian cancer. PMID: 18937968 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Results After Conservative Treatment of Serous Borderline Tumors of the Ovary with a Micropapillary Pattern

Annals of Surgical Oncology — Sat, 27 Sep 2008 13:35:57 +0100

Conclusion This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of SBOT-MP. Nevertheless, as 2/3 of patients had bilateral ovarian involvement at the time of initial management, the recurrence rate is high. However, making definitive conclusions about the safety of conservative surgery is limited by the small sample size. So, further studies are warranted to evaluate conservative management of advanced-stage disease. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-008-0159-9Authors Isabelle Laurent, Institut Gustave-Roussy Service de Chirurgie Gynécologique 39 rue Camille-Desmoulins 94805 Villejuif Cedex FranceCatherine Uzan, Institut Gustave-Roussy Service de Chirurgie Gynécologique 39 rue Ca...

A Comparative Analysis of Lymphatic Vessel Density in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors) With and Without Lymph Node Involvement.

International Journal of Gynecological Pathology — Sat, 20 Sep 2008 09:56:39 +0100

Page: 483DOI: 10.1097/PGP.0b013e3181742d7cAuthors: Fadare, Oluwole M.D.; Orejudos, Michael P. M.D.; Jain, Reena M.D.; Mariappan, M. Rajan M.D., Ph.D.; Hecht, Jonathan L. M.D., Ph.D.; Renshaw, Idris L. M.D., Ph.D.; Hileeto, Denise M.D.; Wang, Sa A. M.D.; Ghofrani, Mohiedean M.D.; Liang, Sharon X. M.D., Ph.D. (Source: International Journal of Gynecological Pathology)

Accuracy of intraoperative frozen section in the diagnosis of ovarian tumors

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Fri, 29 Aug 2008 04:00:00 +0100

Conclusion: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary

BMC Cancer — Sun, 24 Aug 2008 04:00:00 +0100

Conclusion: The present pilot study demonstrates that the GIPC1 protein is overexpressed in ovarian and breast cancer, which may provide an important diagnostic and prognostic marker and will constitute the basis for further study of the role that this protein plays in malignant diseases. In addition, this study suggests that human monoclonal antibodies 27.F7 and 27.B1 should be further evaluated as potential diagnostic tools. (Source: BMC Cancer)

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Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery

Cancer Causes and Control — Fri, 15 Aug 2008 07:10:36 +0100

Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAJennifer A. Doherty, Fred Hutchinson Cancer Researc...

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.

Gynecologic Oncology — Sat, 02 Aug 2008 04:00:00 +0100

CONCLUSION: Downregulation or inactivation of p53, Rb and/or PP2A plays a role in the progression from SBOT to invasive ovarian carcinomas. PMID: 18678400 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference

BioMed Central — Mon, 28 Jul 2008 04:00:00 +0100

The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern regional Cooperative Human Tissue Network (CHTN) and University of Alabama-Birmingham (UAB) Ovarian Spore Center. Thirty-nine mtDNA variants were detected of which 28 were p...

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.

Cancer Control — Sat, 14 Jun 2008 20:37:38 +0100

We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no associ...

Distribution of microsatellite instability in Danish ovarian tumor patients and the prognostic value in ovarian cancer patients.

Oncology Research — Wed, 21 May 2008 17:00:11 +0100

In conclusion, we found no association to any of the clinical parameters evaluated, although a tendency of a higher frequency of MSI was observed among serous OC. PMID: 18488714 [PubMed - in process] (Source: Oncology Research)

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Body size and risk of epithelial ovarian and related cancers: A population-based case-control study

International Journal of Cancer — Wed, 30 Apr 2008 04:00:00 +0100

Laparoscopy-assisted cystectomy for large adnexal cysts

Archives of Gynecology and Obstetrics — Wed, 23 Apr 2008 16:16:55 +0100

Conclusion Laparoscopy-assisted surgery is feasible and safe for women with large benign adnexal cysts and result s in a short surgery time. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0651-2Authors Ahmet Göçmen, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyTuba Atak, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyMustafa Uçar, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyFatih Şanlıkal, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul Turkey Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Sour...

Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis

World Journal of Surgical Oncology — Tue, 22 Apr 2008 04:00:00 +0100

Conclusion: Early surgical intervention, together with careful surveillance and follow-up, can achieve successful long-term outcomes in patients with this rare malignancy. (Source: World Journal of Surgical Oncology)

Serous borderline tumor of the paratestis

Pathology International — Mon, 21 Apr 2008 13:09:38 +0100

Pathology International, Volume 58, Issue 5, Page 311-316, May 2008. Reported herein is a case of serous borderline tumor (SBT, ovarian epithelial type tumor) of the paratestis, involving the tunica vaginalis, in a 64-year-old man. The patient complained of right hydrocele; puncture cytology of the turbid fluid pointed to ... (Source: Pathology International)

Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas

Journal of Hepato-Biliary-Pancreatic Surgery — Sun, 06 Apr 2008 07:00:03 +0100

Conclusions Duodenum-preserving total pancreatic head resection for IPMN, MCN, serous cystadenoma (SCA), and cystic EN lesions is a safe and beneficial surgical procedure. Segmental resection of the duodenum was applied for an oncologically complete resection. In regard to long-term outcome, the procedure is, additionally, a pancreatic cancer preventive strategy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00534-007-1227-4Authors Hans G. Beger, c/o Universitätsklinikum Ulm Steinhövelstrasse 9 D-89075 Ulm GermanyFrank Gansauge, Department of Visceral Surgery Donau-Klinik Neu-Ulm GermanyMarko Siech, Department of General-, Vascular-and Visceral Surgery Ostalb Klinikum Aalen GermanyMichael Schwarz, Department of Visceral Surgery Donau-Klinik Neu-U...

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Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors.

Yonsei Medical Journal — Tue, 01 Apr 2008 04:00:00 +0100

Conclusion: MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon in sporadic ovarian tumors, even by using additional MSI markers. The clinical significance of MSI is not strong in patients with sporadic ovarian tumors. PMID: 18452265 [PubMed - in process] (Source: Yonsei Medical Journal)

Retinoid Receptor Alpha and Beta Expression in Serous Ovarian Tumors.

Oncology — Wed, 12 Mar 2008 04:00:00 +0100

Authors: Daponte A, Kostopoulou E, Chiotoglou I, Vanakara P, Minas M, Nakou M, Kallitsaris A, Kollia P, Koukoulis G, Messinis IE The expression of retinoid acid receptors alpha (RARalpha) and beta (RARbeta) and estrogen receptor alpha (ERalpha) was assessed by immunohistochemistry and Western blotting in normal ovaries, serous cystadenoma (n = 20), serous borderline (n = 14), and serous ovarian cancer (n = 47) and was correlated in cancer cases with stage, grade, progress-free survival (PFS), and survival. RARalpha was increasingly expressed in benign cystadenomas, borderline, and low-stage and advanced-stage neoplasms (p < 0.001). In stage III, G3 serous carcinoma, increased RARalpha expression was an independent prognostic factor associated with lower chemoresponse to first-line c...

Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms.

Gynecologic Oncology — Sat, 08 Mar 2008 05:00:00 +0100

CONCLUSIONS: CEACAM6 is overexpressed in borderline and invasive MON's. PMID: 18331757 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Human papilloma virus (HPV) status, p16(INK4a), and p53 overexpression in epithelial malignant and borderline ovarian neoplasms.

Pathology, Research and Practice — Mon, 25 Feb 2008 10:06:14 +0100

Authors: Giordano G, Azzoni C, D'Adda T, Rocco A, Gnetti L, Froio E, Merisio C, Melpignano M This investigation is the first to evaluate simultaneously human papilloma virus (HPV) status, p16(INK4a), and p53 immunoreactivity in epithelial ovarian neoplasms. The results were analyzed and correlated with histological type, histological grade, and survival of patients. Subtypes considered are papillary serous and mucinous. Polymerase chain reaction (PCR) analysis, performed in our previous study, had already demonstrated a small number of HPV-positive epithelial ovarian neoplasms. No significant correlation was found between the presence of HPV DNA and subtypes of ovarian neoplasms; thus, HPV cannot be considered responsible for epithelial ovarian neoplasm. Since p16 immunoreactivity was ...

[My approach] My approach to and thoughts on the typing of ovarian carcinomas

Journal of Clinical Pathology — Fri, 25 Jan 2008 05:00:00 +0100

Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the distinction between high-grade serous and endometrioid adenocarcinomas and the distinction between a true clear cell carcinoma and clear cell areas within other adenocarcinom...

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Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas

International Journal of Gynecological Cancer — Wed, 23 Jan 2008 21:37:08 +0100

International Journal of Gynecological Cancer, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Woo MMM, Salamanca CM, Miller M, Symowicz J, Leung PCK, Oliveira C, Ehlen TG, Gilks CB, Huntsman D, Auersperg N. Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas. Int J Gynecol ... (Source: International Journal of Gynecological Cancer)

Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas

International Journal of Gynecological Cancer — Wed, 23 Jan 2008 00:00:00 +0100

In conclusion, we have established the first permanent SBOT cell line, which provides a new model to elucidate the undefined relationship of SBOTs to invasive ovarian carcinomas. (Source: International Journal of Gynecological Cancer)

Defining an Appropriate Threshold for the Diagnosis of Serous Borderline Tumor of the Ovary: When Is a Full Staging Procedure Unnecessary?

International Journal of Gynecological Pathology — Sat, 22 Dec 2007 01:39:58 +0100

Page: 10DOI: 10.1097/pgp.0b013e318133a9b7Authors: Allison, Kimberly H. M.D.; Swisher, Elizabeth M. M.D.; Kerkering, Katrina M. M.D.; Garcia, Rochelle L. M.D. (Source: International Journal of Gynecological Pathology)

Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-alpha.

Acta Histochemica — Sat, 01 Dec 2007 05:00:00 +0100

In this study, we compared the immunoreactivities of TGF-alpha and EGF-R in ovarian tumors and related immunohistochemical findings to the histological type of the tumors. Formalin-fixed, paraffin wax-embedded tissue sections from 40 patients who had serous-mucinous borderline tumor and serous-mucinous adenocarcinoma of the ovary (n=10 each) were stained with hematoxylin-eosin and labeled for binding of primary antibodies against TGF-alpha and EGF-R using an avidin-biotin-peroxidase method. A semi-quantitative grading system was used to compare immunohistochemical labeling intensities. Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-alpha was detected in adenocarcinomas. There was no significant difference in the immunoreactivity of TGF-alpha among the histologic t...

Hypoxic status in ovarian serous and mucinous tumors: relationship between histological characteristics and HIF-1α/GLUT-1 expression

Archives of Gynecology and Obstetrics — Tue, 20 Nov 2007 15:24:05 +0100

Conclusion HIF-1α and GLUT-1 expressions seemed to be coordinated to adapt ovarian tumor cells into hypoxic conditions in close association with the acquisition of malignancy. We consider that the relatively strong expression of both markers in serous tumors compared with mucinous tumors is related to the difference in their histological characteristics. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-007-0500-8Authors Tetsuji Iida, Tokai University School of Medicine Department of Obstetrics and Gynecology Kanagawa JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane, Hidaka Saitama 350-1298 JapanMasaki Miyazawa, Tokai University School of Medicine Department of Pathology Kanagawa JapanMarik...

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[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]

Chinese Journal of Cancer — Thu, 01 Nov 2007 04:00:00 +0100

CONCLUSION: The expression of GLUT-1 and the loss of DNA-PKcs may be closely related to the malignant transformation of serous ovarian tumors. PMID: 17991316 [PubMed - in process] (Source: Chinese Journal of Cancer)

The differential diagnosis of primary peritoneal papillary tumors

Archives of Gynecology and Obstetrics — Wed, 10 Oct 2007 16:10:35 +0100

Summary Primary tumors of the peritoneum are rare. Histological differentiation between papillary mesotheliomas, primary ovarian tumors, borderline tumors of the ovary with peritoneal deposits and primary peritoneal carcinoma may be difficult. The expression of vimentin, keratin, pankeratin, CEA, CA125, CA19-9, S100, B 72.3 and BerEP4 was therefore investigated in twelve women with primary malignant peritoneal tumors, twelve women with pleural mesothelioma, eight women with serous ovarian carcinoma and four men with peritoneal mesothelioma. The marker pattern we used was no help in differentiating between metastatic ovarian carcinoma and primary peritoneal carcinomatosis. A combination of the markers S100, B 72.3 and BerEP4 helped the distinction between mesotheliomas and ...

Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

International Journal of Cancer — Thu, 04 Oct 2007 04:00:00 +0100

Sarcomatoid carcinoma arising within a serous borderline ovarian tumour: a case report and practical approach to differential diagnosis

Histopathology — Fri, 28 Sep 2007 12:01:52 +0100

Histopathology Volume 0, Issue 0, Page ???-???. (Source: Histopathology)

Primary peritoneal serous borderline tumor presenting as an "adnexal torsion" gynecologic emergency.

Taiwanese Journal of Obstetrics and Gynecology — Sat, 01 Sep 2007 04:00:00 +0100

PRIMARY PERITONEAL SEROUS BORDERLINE TUMOR PRESENTING AS AN "ADNEXAL TORSION" GYNECOLOGIC EMERGENCY. Taiwan J Obstet Gynecol. 2007 Sep;46(3):308-310 Authors: Lin PY, Ueng SH, Tseng MJ PMID: 17962119 [PubMed - as supplied by publisher] (Source: Taiwanese Journal of Obstetrics and Gynecology)

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Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumours

Histopathology — Tue, 21 Aug 2007 12:04:14 +0100

Histopathology Volume 51, Issue 3, Page 313-321, Sep 2007. Stewart C J R, Brennan B A, Crook M L & Russell P(2007) Histopathology 51, 313–321Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumoursAims: To determine whether elastin stains aid in classifyi... (Source: Histopathology)

Serous cystadenoma of the epididymis.

Urology — Wed, 01 Aug 2007 04:00:00 +0100

We present the first case of a serous cystadenoma of the epididymis in English reports with a brief literature review. PMID: 17826518 [PubMed - in process] (Source: Urology)

Micropapillary Serous Carcinoma: The Solution to the Ovarian Borderline Tumor Conundrum.

Pathology Case Reviews — Thu, 12 Jul 2007 06:10:31 +0100

Page: 136DOI: 10.1097/PCR.0b013e318125674eAuthors: Seidman, Jeffrey D. MD; Varallo, Marisa R. MD (Source: Pathology Case Reviews)

The Development of High-grade Serous Carcinoma From Atypical Proliferative (Borderline) Serous Tumors and Low-grade Micropapillary Serous Carcinoma: A Morphologic and Molecular Genetic Analysis.

The American Journal of Surgical Pathology — Tue, 26 Jun 2007 04:06:49 +0100

Page: 1007DOI: 10.1097/PAS.0b013e31802cbbe9Authors: Dehari, Reiko MD, PhD * +; Kurman, Robert J. MD * +; Logani, Sanjay MD * +; Shih, Ie-Ming MD, PhD * + (Source: The American Journal of Surgical Pathology)

[Borderline serous tumor of the peritoneum: report of two cases]

Annales de Pathologie — Fri, 01 Jun 2007 04:00:00 +0100

We report two cases of peritoneal serous tumor of borderline malignancy, a rare tumor that resembles non invasive peritoneal implants of borderline serous tumor of ovarian origin with absent or minimal surface ovarian involvement. The differential diagnosis includes psammocarcinoma and low grade papillary serous carcinoma of the peritoneum. PMID: 17978699 [PubMed - indexed for MEDLINE] (Source: Annales de Pathologie)

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Laparoscopic restaging of borderline ovarian tumors

Surgical Endoscopy — Sat, 19 May 2007 07:31:21 +0100

Conclusions The results confirm the feasibility and safety of laparoscopic restaging operations for women with borderline ovarian tumors. Cystectomy was associated with a risk of persistent lesions. The risk of upstaging was higher for women with serous borderline ovarian tumors and women with initial FIGO stage I or II disease. Content TypeJournal Article JournalSurgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)

High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour

Histopathology — Fri, 27 Apr 2007 12:47:09 +0100

Histopathology Volume 50, Issue 6, Page 773-779, May 2007. (Source: Histopathology)

Microinvasion links ovarian serous borderline tumor and grade 1 invasive carcinoma.

Gynecologic Oncology — Thu, 26 Apr 2007 04:00:00 +0100

CONCLUSIONS.: Advanced stage at diagnosis was the most important prognostic marker in patients with SBT. Although a micropapillary pattern was common, it did not adversely affect prognosis per se, but was associated with a higher stage. A micropapillary pattern was not seen adjacent to microinvasion or in association with grade 1 serous carcinoma. Microinvasion was common but, in our series, did not appear to worsen the prognosis. Grade 1 serous carcinoma was less common than SBT and had a more unfavorable prognosis. The qualitative histologic similarity between microinvasion, invasive implants, recurrences and grade 1 serous carcinoma suggests that microinvasion represents early invasion and is not just another histologic pattern of SBT. We speculate that some invasive implants and recurr...

Ovarian cancer screening with annual transvaginal sonography

Cancer — Wed, 21 Mar 2007 04:00:00 +0100

Ovarian cancer has the highest mortality rate of all gynecologic malignancies, and most women present with advanced-stage disease. The current investigation was performed to determine the efficacy of annual transvaginal sonography (TVS) as a screening method for ovarian cancer.Annual TVS screening was performed on 25,327 women from 1987 to 2005. Asymptomatic women aged [ge]50 years and women aged [ge]25 years who had a family history of ovarian cancer were eligible for participation in this trial.Among 364 patients (1.4%) with a persisting ovarian tumor on TVS who underwent exploratory laparoscopy or laparotomy with tumor removal, 35 primary invasive ovarian cancers, 9 serous ovarian tumors of low malignant potential, and 7 cancers metastatic to the ovary were detected. Stage distribution ...

Overexpression of mammaglobin B in epithelial ovarian carcinomas.

Gynecologic Oncology — Mon, 05 Mar 2007 05:00:00 +0100

CONCLUSIONS: Mammaglobin B gene is highly expressed in EOC and may represent a novel molecular marker for multiple histological types of ovarian cancer. Additional studies to evaluate the clinical utility of Mammaglobin B as a diagnostic and/or therapeutic target in ovarian cancer are warranted. PMID: 17343903 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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An aggressive surgical approach is warranted in the management of cystic pancreatic neoplasms.

American Journal of Surgery — Thu, 01 Mar 2007 05:00:00 +0100

CONCLUSIONS: Given the poor long-term survival of patients with cystic pancreatic neoplasms containing invasive cancer and the current difficulty to preoperatively distinguish among the various types of lesions in a reliable manner, our data support an aggressive surgical approach to the management of cystic pancreatic neoplasms. PMID: 17320538 [PubMed - in process] (Source: American Journal of Surgery)

Study Data From The United States And Spain Update Ovarian Cancer Knowledge

Cancercompass News: Gynecological Cancer — Mon, 26 Feb 2007 05:00:00 +0100

Researchers in the United States and Spain have published new ovarian cancer data. Study 1: Researchers detail in "The recurrence and the overall survival rates of ovarian serous borderline neoplasms with noninvasive implants is time dependent," new data in ovarian cancer. According to a study from the United States, "Ovarian serous borderline neoplasm with noninvasive implants traditionally have been considered to be nonaggressive tumors associated with an excellent prognosis. However, in our experience, recurrences commonly develop as patients are followed over many years." "Eighty cases of advanced-stage ovarian serous borderline tumor with noninvasive implants were identified; the minimum follow-up period for these cases was 5 yea... (Source: Cancercompass News: Gynecological Cancer)

Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages

Journal of Carcinogenesis — Fri, 26 Jan 2007 07:00:00 +0100

Conclusion: Our findings indicate that certain mtDNA mutations can reliably distinguish the different histologic subtypes of epithelial ovarian tumors. In addition, these data raise the possibility that certain mtDNA mutations may be useful biomarkers for predicting tumor aggressiveness and may play a potential role in tumorigenesis. (Source: Journal of Carcinogenesis)

A series of 64 cases of pancreatic cystic neoplasia from an institutional study of China.

World Journal of Gastroenterology — Thu, 07 Dec 2006 02:02:02 +0100

CONCLUSION: Mucin profile may, in conjunction with histologic study, provide important information on tumor types and patient treatment of cystic neoplasia of the pancreas. PMID: 17143961 [PubMed - in process] (Source: World Journal of Gastroenterology)

Study of ovarian cancer management.

Ir Med J — Wed, 06 Dec 2006 22:12:02 +0100

Authors: Gaughan E, Javaid T, Cooley S, Byrne P, Gaughan G Ovarian cancer is the most lethal gynecological malignancy. Many patients present at an advanced stage as the symptoms of early stage disease can be vague. AIM We evaluated the demographics, treatment regimens and survival rates of ovarian cancer patients attending Beaumont Hospital Dublin over a nine year period. A retrospective chart review of ovarian cancer patients attending Beaumont Hospital between 11/10/94 and 30/6/3 was performed. Patients were selected from pathology records. Patients with borderline histology and those who died of unrelated causes were excluded. 31% of individuals presented with distension as their only clinical sign. 20% presented with a mass as their only clinical sign. The most common cell type was...

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Morphometry and digital AgNOR analysis in cytological imprints of benign, borderline and malignant serous ovarian tumours

Cytopathology — Mon, 27 Nov 2006 17:49:16 +0100

Cytopathology Volume 17, Issue 6, Page 382-389, Dec 2006. (Source: Cytopathology)

Intratesticular borderline serous tumor

International Journal of Urology — Thu, 16 Nov 2006 09:54:59 +0100

International Journal of Urology Volume 13, Issue 12, Page 1536-1538, Dec 2006. (Source: International Journal of Urology)

Differential gene expression identifies subgroups of ovarian carcinoma.

Translational Research — Wed, 01 Nov 2006 05:00:00 +0100

In this study, gene expression in 29 papillary serous ovarian carcinoma samples (21 invasive tumors and 8 borderline tumors), and 17 nonmalignant tissue types comprising 512 samples, was determined using Affymetrix U_133 oligonucleotide microarrays (Affymetrix, Inc., Santa Clara, Calif) representing approximately 40,000 known genes and expression sequence tags (ESTs). Differences in gene expression were quantified as the fold change in gene expression between the various sets of samples. A set of genes was identified that was over-expressed in the invasive ovarian carcinoma samples compared with the normal ovary samples. Principle component analysis of the set of invasive ovarian carcinomas using this set of genes revealed the existence of 2 major subgroups among the invasive ovarian carci...

Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma

Genes, Chromosomes and Cancer — Sun, 24 Sep 2006 01:52:01 +0100

In this study, we describe characteristic chromosomal alterations in a consecutive series of 96 serous ovarian tumors by comparative genomic hybridization. We analyze their association with different pathways of progression, histological grade, and clinical outcome. The most striking difference between low-grade and high-grade serous carcinomas was seen in a higher incidence of chromosomal gains at 3q and 20q and losses of 13q in the high-grade carcinomas. In addition, high-level amplifications were significantly more frequent in high-grade carcinomas, specifically involving regions on 3q and 8q. Chromosomal amplifications of 19p and 19q and losses of 4q and 5q were among the most frequent changes found in both low-grade and high-grade carcinomas, distinguishing them from borderline tumors...

Use of hormone replacement therapy before and after ovarian cancer diagnosis and ovarian cancer survival

International Journal of Cancer — Sun, 24 Sep 2006 01:16:02 +0100

Use of hormone replacement therapy (HRT) has been hypothesized to affect survival of epithelial ovarian cancer (EOC). We studied 5-year survival in patients with invasive EOC and borderline ovarian tumors (BOT) according to HRT use before and after diagnosis in a prospective nation-wide cohort study of 799 women diagnosed with EOC (n = 649) and BOT (n = 150) aged 50-74 years in 1993-1995 in Sweden. Cox regression was used to obtain multivariate age-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariate models included indicator variables for age, tumor stage, grade and histological subtype. After 5 years of follow-up, 45% of the patients with EOC and 93% of the patients with BOT were alive. For women with BOT there were no associations between HRT-use pre- or postdia...

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Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer

Cancer — Tue, 19 Sep 2006 22:39:02 +0100

The objectives of this study were to analyze the real role that these pathways play in ovarian cancer, to correlate them with clinicopathologic characteristics, and to identify the factors that transmit individual proliferation signals and are associated with pathologic grade and prognosis, regardless specific oncogenic alterations upstream.One hundred twenty-nine ovarian epithelial tumors were studied, including 20 serous cystadenomas, 7 mucinous cystadenomas, 11 serous borderline tumors, 16 mucinous borderline tumors, 29 serous carcinomas, 16 endometrioid carcinomas, 15 clear cell carcinomas, and 15 mucinous carcinomas. Tissue microarrays were constructed, and immunohistochemistry for the receptors epidermal growth factor receptor (EGFR) and c-erb-B2 was performed and with phosphorylated...

[Laparoscopic pancreatic resection]

Zentralblatt fur Chirurgie — Tue, 01 Aug 2006 04:00:00 +0100

CONCLUSION: Laparoscopic resection of distal pancreas shows the common benefit of minimal invasive surgery for the early postoperative period and is an attractive alternative for treatment of benign and semimalign pancreatic tumors. PMID: 17004190 [PubMed - indexed for MEDLINE] (Source: Zentralblatt fur Chirurgie)

Expression and mutational analysis of c-kit in ovarian surface epithelial tumors.

J Korean Med Sci — Tue, 14 Feb 2006 07:00:00 +0100

Authors: Kim DJ, Lee MH, Park TI, Bae HI Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas. Five cases of serous cystadenoma and 5 cases of mucinous cystadenoma were also included. In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. Only one case (1/13, 7.7%) of serous cystadenocarcinoma had posit...

Cystic tumors of the pancreas.

Cancer Imaging — Sun, 01 Jan 2006 05:00:00 +0100

Authors: Morana G, Guarise A Cystic tumors of the pancreas are less frequent than solid lesions and are often detected incidentally, as many of these lesions are small and asymptomatic. However, they may be associated with pancreatitis or have malignant potential. With advancements in diagnostic imaging, cystic lesions of the pancreas are being detected with increasing frequency. Many lesions can cause a pancreatic cyst, most being non-neoplastic while approximately 10% are cystic tumors, ranging from benign to highly malignant tumors. With increasing experience it is becoming clear that the prevalence of pseudocyst among cystic lesions of the pancreas is lower than usually presumed. A presumptive diagnosis of pseudocyst based on imaging appearance alone can cause a diagnostic error, a...