MedWorm: Borderline Serous Tumor

The value of frozen section evaluation in the management of borderline ovarian tumors

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: In the frozen section evaluation of BOTs, the underdiagnosis that restricts the diagnostic performance of the method seems to be a major problem. A more careful approach is therefore needed, while choosing a proper surgical technique during laparotomy for ovarian masses. In order to reduce the false diagnosis and surgical morbidity, the frozen section analysis should be applied by experienced pathologists and the possible predictive factors affecting a false diagnosis should carefully be taken into consideration. (Source: Journal of Cancer Research and Therapeutics)

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Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)

CT appearance of primary peritoneal serous borderline tumour: a rare epithelial tumour of the peritoneum.

The British Journal of Radiology — Mon, 26 Dec 2011 18:24:22 +0100

We report the CT findings of surgically proven PPSBT in which multiple peritoneal cysts were seen. Although rare, PPSBT should be considered in the differential diagnosis of primary peritoneal tumours. Since the prognosis of the disease is good, conservation of the uterus and ovaries should be a consideration in young female patients during surgery. PMID: 22190758 [PubMed - in process] (Source: The British Journal of Radiology)

Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival

Histopathology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions: Our findings suggest that Dock180 contributes to ovarian carcinogenesis and dissemination and is a potential prognostic marker and therapeutic target. (Source: Histopathology)

Low‐grade serous carcinomas of the ovary contain very few point mutations

The Journal of Pathology — Mon, 21 Nov 2011 05:00:00 +0100

AbstractIt has been well established that ovarian low‐grade and high‐grade serous carcinomas are fundamentally different types of tumours. While the molecular genetic features of ovarian high‐grade serous carcinomas are now well known, the pathogenesis of low‐grade serous carcinomas, apart from the recognition of frequent somatic mutations involving KRAS and BRAF, is largely unknown. In order to comprehensively analyze somatic mutations in low‐grade serous carcinomas, we applied exome sequencing to the DNA of eight samples of affinity‐purified low‐grade serous carcinomas. A remarkably small number of mutations were identified in seven of these tumours: a total of 70 somatic mutations in 64 genes. The eighth case displayed mixed serous and endometrioid features and a mutator p...

Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution

Pediatric Surgery International — Wed, 16 Nov 2011 18:00:12 +0100

Conclusions The majority of pediatric ovarian tumors were benign disease, and the patients with malignant lesions had a good prognosis. In neonatal cases, an umbilical crease incision approach is feasible and provides excellent cosmesis. We recommend tumor resection with ovarian preservation through a minimally invasive approach (modified Rocky Davis incision) as the first line treatment for older pediatric patients with ovarian tumors other than those preoperatively diagnosed as malignant. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s00383-011-3004-3Authors Tatsuro Tajiri, Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanRyota Souzaki, Departmen...

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Laparoscopic management of large ovarian tumors: Clinical tips for overcoming common concerns

Journal of Obstetrics and Gynaecology Research — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion: Laparoscopic management of large ovarian tumors is feasible and efficient with appropriate patient selection and experience of surgeons. (Source: Journal of Obstetrics and Gynaecology Research)

Leak-proof extracorporeal drainage for management of large ovarian tumors

Archives of Gynecology and Obstetrics — Fri, 21 Oct 2011 16:00:26 +0100

Conclusions Minilaparotomy with leak-proof extracorporeal drainage using cyanoacrylate adhesive and polyurethane membrane is reliable, safe, and feasible for management of large ovarian tumors with low probability of malignancy in selected patients. Content Type Journal ArticleCategory General GynecologyPages 1-4DOI 10.1007/s00404-011-2115-3Authors Shih-Shien Weng, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 TaiwanYeou-Lih Wang, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 Taiwan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Malignant Transformation of a Serous Borderline Tumor and Early Metastasis of Associated Low-Grade Serous Carcinoma Detected on Screening Mammography [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Tue, 18 Oct 2011 04:00:00 +0100

(Source: Journal of Clinical Oncology)

Copy number aberrations in benign serous ovarian tumors: a case for reclassification?

Clinical Cancer Research — Wed, 05 Oct 2011 04:00:00 +0100

CONCLUSIONS: Chromosome 12 trisomy has been previously identified in pure fibromas, supporting the concept that a significant proportion of benign serous tumors are primary fibromas with an associated cystic mass. This is the first high resolution genomic analysis of benign serous ovarian tumors and demonstrates not only that the majority of benign serous tumors have no genetic evidence of epithelial neoplasia but that a significant proportion may be more accurately classified as primary fibromas. PMID: 21976534 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Epithelial Ovarian Tumors in Adolescents: A Retrospective Pathologic Study and a Critical Review of the Literature

Journal of Pediatric and Adolescent Gynecology — Mon, 26 Sep 2011 04:00:00 +0100

Conclusions: A relatively high frequency of epithelial ovarian neoplasms among all ovarian tumors in a purely adolescent population was found in our study. Age-related selection bias may account at least in part for the discrepancy between our data and most previous reports. The most common subtype of epithelial ovarian tumor in our series was the benign serous cystadenoma. (Source: Journal of Pediatric and Adolescent Gynecology)

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Folate, vitamin B6, vitamin B12, methionine and alcohol intake in relation to ovarian cancer risk

International Journal of Cancer — Thu, 22 Sep 2011 04:00:00 +0100

AbstractFolate, methionine, vitamin B6, and vitamin B12 may influence carcinogenesis due to their roles in the one‐carbon metabolism pathway which is critical for DNA synthesis, methylation, and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon, and endometrial cancers. Previous studies that have examined the relation between these nutrients and ovarian cancer risk have been inconsistent and have had limited power to examine the relation by histologic subtype. We investigated the association between folate, methionine, vitamin B6, vitamin B12, and alcohol among 1910 women with ovarian cancer and 1989 controls from a case‐control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008. Diet was assessed via food freque...

Accuracy of frozen section diagnosis of ovarian borderline tumor.

Gynecologic Oncology — Tue, 13 Sep 2011 04:00:00 +0100

CONCLUSION: Comprehensive surgical staging can be considered in BT >8cm in diameter, as well as those with micropapillary serous, endometrioid, and clear cell histology diagnosed at the time of frozen section analysis. PMID: 21920591 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Micropapillary pattern in serous borderline ovarian tumors: Does it matter?

Gynecologic Oncology — Mon, 12 Sep 2011 04:00:00 +0100

CONCLUSIONS: Because micropapillary SBOT was significantly associated with peritoneal implants, especially invasive implants, and lymph node involvement, complete staging procedures, including lymph node dissection, are recommended. However, micropapillary SBOT itself was not significantly associated with DFS. Peritoneal implant was the only factor independently associated with tumor recurrence. PMID: 21917305 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Behavior of Serous Borderline Ovarian Tumors With and Without Micropapillary Patterns: Results of a French Multicenter Study

Annals of Surgical Oncology — Wed, 31 Aug 2011 05:51:32 +0100

Conclusions Patients with MP-SBOT represent a heterogeneous population in terms of presence of invasive peritoneal implants. Conservative surgery could be a suitable option for MP-SBOT patients without implants and who wish to conserve childbearing potential, without increasing the risk of recurrence. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1245/s10434-011-2039-yAuthors R. Fauvet, Department of Gynecology and Obstetrics, University Hospital of Amiens, University of Picardie, Jules Verne, Amiens, FranceE. Demblocque, Department of Gynecology and Obstetrics, University Hospital of Amiens, University of Picardie, Jules Verne, Amiens, FranceP. Morice, Department of Gynecologic Surgery, Gustave Roussy Cancer Institute, University of Paris...

Ovarian cancer during pregnancy

International Journal of Gynaecology and Obstetrics — Mon, 29 Aug 2011 04:00:00 +0100

Conclusion: Early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. Tumor staging is possible during pregnancy, but the appropriateness of surgery needs to be considered carefully. Ideally, the treatment strategy should be discussed and structured on an individual basis. (Source: International Journal of Gynaecology and Obstetrics)

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Epiregulin as a marker for the initial steps of ovarian cancer development.

International Journal of Oncology — Wed, 13 Jul 2011 23:00:00 +0100

Authors: Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben-Arie A, Prus D, Schreiber L Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner. However, there were no systematic follow-up studies of Ep expression in the development of different stages of ovarian cancer. Using specific antibodies to Ep and the indirect immunocytochemistry methods, we found that in normal ovary the staining for Ep was mainly confined to the epithelial cells, while the stromal cells were only occasionally and moderately stained. In contrast in benign serous and mucinous tumors most of the tumor cells showed a clear staining in the cytoplasm. In borderline serous and mucinous tumors the staining was mu...

Paratubal Borderline Tumor Diagnosed In The Adolescent Period: A Case Report And Review of The Literature

Journal of Pediatric and Adolescent Gynecology — Thu, 07 Jul 2011 23:00:00 +0100

Conclusion: The evaluation of the structure of cyst by ultrasound and the performance of intraoperative frozen section analysis are two important issues to diagnose the nature of a cyst. Fertility-sparing surgery is the main point of management. (Source: Journal of Pediatric and Adolescent Gynecology)

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Archives of Gynecology and Obstetrics — Wed, 29 Jun 2011 10:52:48 +0100

Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. Content Type Journal ArticlePages 1-5DOI 10.1007/s00404-011-1957-zAuthors A. Kondi-Pafiti, Pathology Laboratory, University of Athens, Athens, GreeceE. Papakonstantinou, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Iavazzo, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Grigoriadis, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofi...

Robot-Assisted Spleen-Preserving Laparoscopic Distal Pancreatectomy

Annals of Surgical Oncology — Sun, 12 Jun 2011 06:04:34 +0100

Conclusions The unique characteristics of a robotic surgical system were thought to be very helpful during the spleen-preserving laparoscopic distal pancreatectomy.2 – 6 However, cost is one of the main obstacles for the procedure’s popular clinical practice.2 Content Type Journal ArticlePages 1-1DOI 10.1245/s10434-011-1816-yAuthors Sung Hoon Choi, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaChang Moo Kang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaWoo Jung Lee, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaHoon Sang Chi, Division of Hepatobiliary and P...

Borderline papillary serous tumor of the fimbriated end of the fallopian tube with peritoneal implants

Journal of Obstetrics and Gynaecology Research — Wed, 08 Jun 2011 23:00:00 +0100

AbstractDiagnosis of Borderline papillary serous tumor of the fallopian tube was comprehensively established by Zheng in 1996 supported mostly by a histological similarity to its ovarian counterpart. It is a very rare entity with eight cases published so far and the ninth case described here as a 41‐year‐old woman presented with non‐specific lower abdominal pain, dyspareunia and dysuria. Left adnexal mass was identified and she was operated on. It turned out the tumor was attached exclusively to the left tube, with no connection to any of the surrounding structures and with histology of borderline serous tumor with non‐invasive implants in the left and right ovary and visceral peritoneum. Reviewing available data on genetics of these tumors there was diploid status in one examined ...

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Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor

Journal of Assisted Reproduction and Genetics — Wed, 08 Jun 2011 15:46:48 +0100

Conclusion(s) Mature oocytes were successfully retrieved ex-vivo from the hyperstimulated ovary recovered via laparoscopy. The procedure can be performed in a quick manner, with standard equipment, without damaging the ovary, the follicles or the oocytes, and without the risk of cancer cell spillage associated with the standard transvaginal oocyte retrieval if there is concern of ovarian surface/peritoneal metastatic disease. Content Type Journal ArticlePages 1-2DOI 10.1007/s10815-011-9596-7Authors Silvina Bocca, The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 605 Colley Ave., Norfolk, VA, USADaynelle Dedmond, Sentara Surgery Specialists, Williamsburg, VA, USAEstella Jones, The Jones Institute ...

Laparoendoscopic single-site surgery (LESS) for adnexal tumors: one surgeon's initial experience over a one-year period

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 16 May 2011 04:00:00 +0100

Conclusions: Our results suggest that LESS is a safe and feasible alternative to conventional laparoscopic surgery for the treatment of adnexal tumors. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]

Radiographics recent issues — Wed, 11 May 2011 23:00:00 +0100

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelomic spread of disease beyond the ovaries, whereas low-grade serous and mucinous carcinomas commonly manifest w...

[An ovarian mucinous borderline tumour with mixed mural nodules.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Wed, 27 Apr 2011 23:00:00 +0100

We report an additional case of mixed type mural nodules of anaplastic carcinoma and sarcoma-like developed in an ovarian mucinous borderline tumour at a 60-year-old woman.We give details about the classification, the differential diagnosis and prognosis of theses nodules. PMID: 21531088 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy

Advances in Pharmacological Sciences — Tue, 26 Apr 2011 14:23:42 +0100

Conclusions. Despite the small number of samples used in this study, the results indicate that metabolomic analysis of intact tissues by HRMAS-NMR is a promising technique which might be applicable to the therapeutic management of patients. (Source: Advances in Pharmacological Sciences)

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Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells

Oncogene — Sun, 10 Apr 2011 23:00:00 +0100

Authors: J-C Cheng, N Auersperg & P C K Leung (Source: Oncogene)

Ovarian borderline tumours: a review with emphasis on controversial areas

Diagnostic Histopathology — Tue, 29 Mar 2011 21:12:46 +0100

Abstract: Ovarian borderline tumours are relatively uncommon, but by no means rare, neoplasms. Most are of serous or mucinous type with other morphological variants being much more uncommon. This review discusses the pathological features and some clinical aspects of ovarian borderline tumours, concentrating on those of serous and mucinous type. Borderline endometrioid, Brenner and clear cell tumours are briefly discussed. Controversial and often poorly understood topics covered include the relationship between borderline tumours and carcinomas, the criteria for and significance of microinvasion, the significance of a micropapillary architecture in a serous borderline tumour, the diagnostic criteria for and significance of extraovarian “implants”, lymph node involvement, staging issues...

Isobaric laparoendoscopic single-site surgery with wound retractor for adnexal tumors: a single center experience with the initial 100 cases

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 14 Mar 2011 00:00:00 +0100

Conclusions: With efficient wound retraction to create a wide and flexible orifice during instrumentation, the transumbilical wound retraction system combined with the subcutaneous abdominal wall-lift method contributes favorably to LESS surgery as a safe, feasible and reproducible alternative for a variety of ablative and reconstructive applications in the management of adnexal tumors. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Benign and Low Grade Serous Epithelial Tumors: Recent Developments and Diagnostic Problems

Surgical Pathology Clinics — Tue, 01 Mar 2011 00:00:00 +0100

Abstract: This review focuses on recent advances in the area of low-grade ovarian serous neoplasia with emphasis on key diagnostic criteria, differential diagnosis, and disease classification based on current understanding of low-grade serous carcinogenesis. Despite considerable controversy surrounding serous tumors of low malignant potential (S-LMP) or borderline tumors, there have been great strides in our understanding of the serous group of borderline and malignant pelvic epithelial neoplasms in the past decade. Most S-LMP have a favorable prognosis, but recurrences and progression to carcinoma occur, sometimes following a protracted clinical course. Pathologic risk factors vary, but the extraovarian implant status is the most important predictor for progressive disease. Progression of...

Prognostic value of lymph node involvement in ovarian serous borderline tumors

American Journal of Obstetrics and Gynecology — Fri, 25 Feb 2011 00:00:00 +0100

Conclusion: Lymph node involvement does not appear as a prognosis factor for advanced-stage BOT. (Source: American Journal of Obstetrics and Gynecology)

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How to follow up advanced-stage borderline tumours? Mode of diagnosis of recurrence in a large series stage II-III serous borderline tumours of the ovary

Annals of Oncology — Tue, 22 Feb 2011 00:00:00 +0100

Conclusions: This study demonstrates that ultrasound is the most relevant follow-up procedure in this context. Nevertheless, the blood CA 125 test is of particular interest for detecting invasive recurrent disease, which is the most crucial event. (Source: Annals of Oncology)

Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis.

Neoplasma — Wed, 16 Feb 2011 18:15:03 +0100

Authors: Jia L, Yi XF, Zhang ZB, Zhuang ZP, Li J, Chambers SK, Kong BH, Zheng W <p>The exact role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian epithelial carcinoma (OEC) development has not been yet characterized. This prompted us to identify particular proteins to better understand the underlying mechanism. Total proteins from ovarian epithelial tumor (OET) cells treated with gonadotropins were analyzed by proteomics. Western blot and immunohistochemistry were used to validate the target protein (prohibitin) and to detect its expression in human ovarian tissue of serous tumors. As the results, prohibitin was found to be significantly up-regulated by LH, with a maximum of 2.5-fold increase at the concentration of 200 mIU/mL. </p><p>Th...

Ovarian serous surface papillary borderline tumors form sea anemone‐like masses

Journal of Magnetic Resonance Imaging — Tue, 01 Feb 2011 00:00:00 +0100

ConclusionSSPBT, which has more favorable prognosis than those of flank ovarian carcinoma, is characterized by a solid mass with papillary architecture and internal branching resembling a sea anemone on MR. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc. (Source: Journal of Magnetic Resonance Imaging)

Unusual Presentation of Benign Cystic Brenner Tumor With Exuberant Psammomatous Calcifications

International Journal of Surgical Pathology — Mon, 31 Jan 2011 00:00:00 +0100

This study reports a case of benign Brenner tumor with exuberant dystrophic calcifications that obscured most of the epithelium and posed a diagnostic challenge in differentiating it from the more common malignant counterparts such as serous carcinoma and specifically psammocarcinoma. (Source: International Journal of Surgical Pathology)

"Surface epithelial changes" in uterine endometrioid carcinoma mimicking micropapillary serous borderline tumor of ovary: report of two cases and review of the literature

Diagnostic Pathology — Thu, 27 Jan 2011 00:00:00 +0100

This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important. (Source: Diagnostic Pathology)

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Prognosis and Prognostic Factors of the Micropapillary Pattern in Patients Treated for Stage II and III Serous Borderline Tumors of the Ovary.

The Oncologist — Thu, 27 Jan 2011 00:00:00 +0100

Conclusions. In the present series, an MP pattern doesn't appear to signify a poor prognosis. The only prognostic factor for recurrence in SBOT-MP was the use of conservative surgery. Further studies on the MP pattern are needed to evaluate prognosis and the results of conservative surgery. PMID: 21273510 [PubMed - as supplied by publisher] (Source: The Oncologist)

Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer.

Gynecologic Oncology — Wed, 12 Jan 2011 00:00:00 +0100

CONCLUSION: These results indicate that p-trkA may be considered as a new potential tumor marker in EOC, and that NGF may also act as a direct angiogenic factor in EOC. PMID: 21236475 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Fertility outcome after conservative surgery for borderline ovarian tumors: a single center experience

Archives of Gynecology and Obstetrics — Fri, 17 Dec 2010 17:38:51 +0100

Conclusions The primary treatment of borderline ovarian tumors refers to conservative surgery. Younger age, non-serous histology and unilateral cystectomy appear to be associated with favorable reproductive outcome in women who undergo conservative surgery for borderline malignancy of ovary. Content Type Journal ArticleDOI 10.1007/s00404-010-1804-7Authors Mine Kanat-Pektas, Department of Gynecologic Oncology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170 Ankara, TurkeyMustafa Ozat, Department of Gynecologic Oncology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170 Ankara, TurkeyTayfun Gungor, Department of Gy...

Risk factors for recurrence of ovarian borderline tumors.

Gynecologic Oncology — Thu, 09 Dec 2010 00:00:00 +0100

CONCLUSION: Age at diagnosis, an elevated preoperative CA-125, invasive implants, and micropapillary histology were clinical factors associated with increased risk of recurrence in women with BOT. Including these clinicopathologic features will likely identify patients at higher risk for recurrence, for whom development of new treatment strategies would be appropriate. PMID: 21146201 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Molecular Characterization of 103 Ovarian Serous and Mucinous Tumors.

Pathology Oncology Research — Tue, 07 Dec 2010 00:00:00 +0100

Authors: Vereczkey I, Serester O, Dobos J, Gallai M, Szakács O, Szentirmay Z, Tóth E The pathogenesis of ovarian carcinomas is heterogeneous, with even the same entities showing great variance. In our study we investigated the mutations of the BRAF, KRAS, and p53 genes in serous and mucinous borderline tumors and in low grade and high grade serous and mucinous tumors. The mutations of BRAF and KRAS genes have been shown in 60% of borderline and low grade (well differentiated) serous and mucinous tumors, but very rarely in high grade (moderately and poorly differentiated) carcinomas. However mutations of p53 are very common in high grade tumors and this indicates a "dualistic" model of ovarian tumorigenesis. A total of 80 serous tumors, including serous borderline, low grade and high ...

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Ex-vivo oocyte retrieval for fertility preservation

Fertility and Sterility — Mon, 06 Dec 2010 00:00:00 +0100

Conclusion(s): Mature oocytes can be successfully retrieved ex-vivo from the oophorectomy specimen after a controlled ovarian hyperstimulation (COH) protocol. This method provides a possible strategy for fertility preservation in patients with recurrent ovarian cancer without the risk of cancer cells spillage associated with the standard transvaginal oocyte retrieval. (Source: Fertility and Sterility)

Appendiceal pathology at the time of oophorectomy for ovarian neoplasms.

Obstetrics and Gynecology — Mon, 29 Nov 2010 19:47:46 +0100

CONCLUSION:: The prevalence of coexisting, clinically significant appendiceal pathology is low with a frozen section diagnosis of serous or mucinous cystadenoma. Appendectomy is recommended when frozen section diagnosis is mucinous or serous ovarian carcinoma, borderline tumor or metastatic carcinoma of suspected gastrointestinal origin. LEVEL OF EVIDENCE:: III. PMID: 21099601 [PubMed - in process] (Source: Obstetrics and Gynecology)

Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors

Modern Pathology AOP — Fri, 19 Nov 2010 00:00:00 +0100

Authors: Ingrid T G W Bijsmans, Kim M Smits, Pauline de Graeff, G Bea A Wisman, Ate G J van der Zee, Brigitte F Slangen, Adriaan P de Bruïne, Manon van Engeland, Nathalie L Sieben & Koen K Van de Vijver (Source: Modern Pathology AOP)

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

BMC Cancer — Mon, 08 Nov 2010 00:00:00 +0100

Conclusion: Plexin-B1 expression correlates with malignant phenotypes of serous ovarian tumors, probably via phosphorylation of AKT at Ser473, suggesting that Plexin-B1 might be a useful biomarker and/or a novel therapeutic target. (Source: BMC Cancer)

Deregulation of miR‐519a, 153, and 485‐5p and its clinicopathological relevance in ovarian epithelial tumours

Histopathology — Mon, 01 Nov 2010 00:00:00 +0100

Conclusions: A significant correlation was detected between the deregulation of specific types of miRNAs, such as miR‐519a, miR‐153 and miR‐485‐5p, and clinical variables as well as histological subtypes in ovarian cancers. Hence, these miRNAs may perform functions as diagnostic or prognostic biomarkers. (Source: Histopathology)

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Serous borderline tumor of the fallopian tube in a patient with Klippel-Trenaunay syndrome

Journal of Pediatric Surgery — Fri, 29 Oct 2010 22:28:22 +0100

We describe a case of a 3-year-old girl with Klippel-Trenaunay syndrome who presented with an enlarging abdominal mass caused by a serous borderline tumor of the fallopian tube. This case is notable for the rarity of this neoplasm in a premenarchal patient as well as the association with this syndrome. We briefly review these entities and the significance of malignancy in Klippel-Trenaunay syndrome. (Source: Journal of Pediatric Surgery)

Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin

Oncogene — Sun, 24 Oct 2010 23:00:00 +0100

Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin Oncogene advance online publication, October 25, 2010. doi:10.1038/onc.2010.486 Authors: J-C Cheng, N Auersperg & P C K Leung (Source: Oncogene)

Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis

American Journal of Obstetrics and Gynecology — Thu, 21 Oct 2010 00:00:00 +0100

Conclusion: The findings support the view that low-grade and high-grade serous carcinomas are distinctly different with low-grade, but not high-grade, serous carcinomas that are related to serous borderline tumor and cystadenoma. (Source: American Journal of Obstetrics and Gynecology)

Ten years experience in the management of borderline ovarian tumors at Tom Baker Cancer Centre

Archives of Gynecology and Obstetrics — Wed, 20 Oct 2010 17:54:15 +0100

Conclusions The indications for restaging surgery remain controversial, as there was no difference in recurrence rates observed between the study groups. However, surgical staging is important for identifying invasive extraovarian implants that need to be treated with chemotherapy. For patients who have conservative surgery, close- and long-term follow-up is required. Content Type Journal ArticleDOI 10.1007/s00404-010-1713-9Authors Nisrin Anfinan, Department of Gynecology Oncology, Tom Baker Cancer Centre, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, CanadaKhalid Sait, Department of Obstetrics and Gynecology, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaPrafull Ghatage, Department of Gynecology Oncology, Tom Baker Cancer Centre, 3330 Hospital Drive NW, Ca...

Management and outcomes of adnexal torsion: a 5-year experience

Archives of Gynecology and Obstetrics — Tue, 05 Oct 2010 05:45:33 +0100

Conclusion Laparoscopy is preferred for young patients who want to preserve their fertility. Because of high risk of malignancy in postmenopausal ovarian masses presenting with torsion; frozen section should be used. If not possible or not conclusive, staging surgery is more appropriate especially if there is suspicion of malignancy. Content Type Journal ArticleDOI 10.1007/s00404-010-1702-zAuthors Osman Balci, Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Meram, 42080 Konya, TurkeyMehmet S. Icen, Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Meram, 42080 Konya, TurkeyAlaa S. Mahmoud, Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Meram, 42080 Konya, Turke...

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Pediatric borderline ovarian tumors: a retrospective analysis

Journal of Pediatric Surgery — Thu, 30 Sep 2010 23:00:00 +0100

Conclusions: This study shows that BOTs in pediatric populations can be successfully treated conservatively to preserve fertility with no apparent increased risk of morbidity or mortality compared with those of more radical surgical options. (Source: Journal of Pediatric Surgery)

Expression of octamer-4 in serous and mucinous ovarian carcinoma

Journal of Clinical Pathology — Mon, 27 Sep 2010 16:04:19 +0100

Conclusion Results suggest that Oct4 expression may contribute to the initiation, promotion and progression of serous ovarian carcinoma; it might be a useful biomarker for the diagnosis and outcome prediction of serous ovarian carcinoma. (Source: Journal of Clinical Pathology)

MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

BMC Cancer — Thu, 16 Sep 2010 23:00:00 +0100

Background: The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods: Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results: MAL2 and TPD5...

Interventions for the treatment of borderline ovarian tumours.

Cochrane Database of Systematic Reviews — Sun, 12 Sep 2010 02:48:06 +0100

CONCLUSIONS: We did not find evidence to support the use of any specific type of adjuvant therapy for borderline ovarian tumours. RCTs evaluating the benefit of adjuvant therapy with optimally dosed chemotherapy and newer targeted drugs are necessary, particularly for advanced borderline ovarian tumours. The low mortality from borderline ovarian tumours should make recurrence-free survival, time to recurrence and morbidity important end points in such trials.Bilateral cystectomy may be offered to women with bilateral borderline ovarian tumours diagnosed intra-operatively who are wishing to preserve their fertility. Similarly, women who had RCTs comparing radical with conservative surgery and comparing laparoscopy with laparotomy are needed. PMID: 20824864 [PubMed - in process] (Source:...

BRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas.

Am J Pathol — Thu, 26 Aug 2010 23:00:00 +0100

In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of heterozygosity. We then analyzed 91 ovarian tumor samples for mutations in TP53, BRAF, and KRAS. TP53 mutations were not detected in any serous borderline tumors (n = 30) or low-grade serous carcinomas (n = 43) but were found in 73% of high-grade serous carcinomas (n = 18). BRAF (n = 9) or KRAS (n = 5) mutation was detected in 47% of serous borderline tumors, but among the low-grade serous carcinomas (39 stage III, 2 stage II, and 2 stage I), only one (2%) had a BRAF mutation and eight (19%) had a KRAS mutation. The low frequency of BRAF mutations in advanced-stage, low-grade serous carcinomas, which contrasts with previou...

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Patterns of recurrence and role of adjuvant chemotherapy in stage II-IV serous ovarian borderline tumors.

Gynecologic Oncology — Sun, 15 Aug 2010 23:00:00 +0100

CONCLUSIONS: While advanced-stage ovarian SBT generally has a good prognosis, nearly 21% of patients develop recurrent disease with intermediate follow-up. It is unclear from these data if adjuvant chemotherapy influenced PFS. PMID: 20719369 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Serous and mucinous borderline ovarian tumors: are there real differences between these two entities?

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Wed, 11 Aug 2010 00:00:00 +0100

Abstract: Objective: To evaluate the clinical outcome and pathological features of patients with borderline ovarian tumors (BOT) with special emphasis on serous and mucinous histology.Study design: Medical and anatomopathological records were reviewed in the Gynecological Oncology Department of the Canarian University Hospital between 1990 and 2005. Survival rates were analyzed by using the Kaplan–Meier technique.Results: The study included 163 patients. Serous tumors corresponded to 68 cases and mucinous tumors to 91 cases. Eighty-nine percent of patients were at FIGO stage I, 1.2% at stage II and 9.8% at stage III. Serous histology was significantly related to the presence of peritoneal implants (22.4% vs 3.6%; p=0.001), positive peritoneal cytology (35.7% vs 8.5%; p=0.001) and bilater...

Ovarian Cancer Development and Metastasis.

The American Journal of Pathology — Wed, 21 Jul 2010 23:00:00 +0100

Authors: Lengyel E The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only superficially invasive. However, since the rapidly proliferating tumors compress visceral organs and are only temporarily chemosensitive, ovarian carcinoma is a deadly disease, with a cure rate of only 30%. There are a number of genetic and epigenetic changes that lead to ovarian carcinoma cell transformation. Ovarian carcinoma could originate from any of three potential sites: the surfaces of the ovary, the fallopian tube, or the mesothelium-lined peritoneal cavity. Ovarian cacinoma tumorigenesis then either progresses along a stepwise mutation process from a slow growing borderline tum...

Cystic lesions of the pancreas: clinical and pathologic review of cases in a five year period.

JOP — Mon, 12 Jul 2010 16:27:04 +0100

CONCLUSION: Cystic lesions are found in 20.6% of all pancreatectomy specimens. Among this heterogeneous group, benign neoplasms predominate, particularly those with mucinous lining. Age at presentation, gender, location and tumor size are highly variable, with the exception of solid pseudopapillary tumor. Clinical presentation, diagnostic imaging and laboratory data should be consistently reported to improve the therapeutic approach. PMID: 20601810 [PubMed - in process] (Source: JOP)

ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139.

International Journal of Oncology — Sat, 03 Jul 2010 19:54:49 +0100

Authors: Chay D, Cho H, Lim BJ, Kang ES, Oh YJ, Choi SM, Kim BW, Kim YT, Kim JH Characterization of a newly established serous ovarian cancer cell line, YDOV-139 was performed and ER-60 (PDIA3), which was highly expressed in YDOV-139, was evaluated as novel biomarker for ovarian cancer. The YDOV-139 cell line was established using ascites samples from a 67-year-old Korean woman with recurrent ovarian cancer, and was characterized with respect to various biological and genetic features. Gene expression profiles were analyzed using cDNA microarrays, and proteomic evaluation was performed by two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption ionization-time of flight peptide mass fingerprinting (MALDI-TOF/PMF). Four candidate markers that were strongly up-regu...

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Complete lymph node dissection: is it essential for the treatment of borderline epithelial ovarian tumors?

Archives of Gynecology and Obstetrics — Mon, 14 Jun 2010 14:27:23 +0100

Conclusions Retroperitoneal evaluation can be spared in every woman with borderline ovarian tumor unless she is to undergo complete surgical staging procedure because of high recurrence risk, advanced stage disease or personal choice. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1539-5Authors Mine Kanat-Pektas, Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Gynecologic Oncology Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle 06170 Ankara TurkeyMustafa Ozat, Dr. Zekai Tahir Burak Women Health Research and Education Hospital Department of Gynecologic Oncology Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle 06170 Ankara TurkeyTayfun Gungor, Dr. Zekai Tahir Burak Women Health Research and Educat...

Risk of malignancy in sonographically confirmed septated cystic ovarian tumors.

Gynecologic Oncology — Sun, 13 Jun 2010 23:00:00 +0100

CONCLUSIONS: Septated cystic ovarian tumors without solid areas or papillary projections have a low risk of malignancy and can be followed sonographically without surgery. PMID: 20554314 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Fertility results and outcomes after pure laparoscopic management of advanced-stage serous borderline tumors of the ovary

Fertility and Sterility — Thu, 10 Jun 2010 00:00:00 +0100

The outcomes of 18 patients treated with pure laparoscopic management (treated conservatively in 14 patients) of serous borderline ovarian tumors with peritoneal implants were reviewed. Eight patients relapsed (three with an invasive recurrence), but none of the patients without residual disease at the end of surgery, or invasive implants or disease with a micropapillary pattern relapsed under the form of invasive carcinoma. (Source: Fertility and Sterility)

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer

European Journal of Cancer — Sun, 23 May 2010 23:00:00 +0100

In this study, we applied proteomic techniques to analyse the protein expression profiles of SOC and normal ovarian epithelium tissues. Totally 54 aberrantly expressed proteins were identified using 2-DE combined with MALDI-TOF/TOF. Six of these proteins were validated by western blot. Corresponding gene expression analysis of these proteins was also performed using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). Additionally, we analysed glia maturation factor beta (GMFB) protein expression by immunohistochemistry in 246 patients with various degrees of ovarian epithelial lesions. GMFB expression in SOC was found to be significantly enhanced than that in normal epithelium, benign serous adenoma and borderline serous adenoma tissues, and was positively corr...

Ovarian cancer takes center stage

DF/HCC: Latest News — Mon, 29 Mar 2010 23:15:00 +0100

Most women with ovarian cancer are diagnosed in their 60s and 70s with advanced stage disease that has spread throughout the abdomen. Although the cancer usually responds to chemotherapy, it frequently recurs and the patient dies from resistant disease. To tackle these vexing clinical features, investigators in the DF/HCC Gynecologic Cancer Program are making fundamental and potentially transformative observations in screening, disease biology, and molecular tools for targeted prevention, treatment and prognosis.Were learning a lot, says program leader Michael Birrer, MD, PhD (MGH). I believe the landscape will change radically in the next five years. This is encouraging for women with ovarian cancer. In the DF/HCC program, current ovarian cancer research spans an individualized...

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Ovarian cancer research takes center stage

DF/HCC: Latest News — Mon, 29 Mar 2010 23:15:00 +0100

Expression of Sox2 in human ovarian epithelial carcinoma

Journal of Cancer Research and Clinical Oncology — Fri, 26 Mar 2010 19:19:27 +0100

Conclusion The expression level of Sox2 in human ovarian tumors was directly proportional to their degree of malignancy, implying that Sox2 overexpression may be closely related to the malignant transformation of ovarian tumors. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0867-yAuthors Feng Ye, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine Xueshi Rd#2 Hangzhou 310006 ChinaYanli Li, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine Xueshi Rd#2 Hangzhou 310006 ChinaYing Hu, Zhejiang University Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital, School ...

Ovarian serous low malignant potential (borderline) tumor - Does "micropapillary" matter?

Gynecologic Oncology — Sun, 21 Mar 2010 19:36:06 +0100

Ovarian serous low malignant potential (borderline) tumor - Does "micropapillary" matter? Gynecol Oncol. 2010 Apr;117(1):1-3 Authors: Shih IeM PMID: 20298906 [PubMed - in process] (Source: Gynecologic Oncology)

Serous borderline tumor of the fallopian tube presented as an adnexal mass

Archives of Gynecology and Obstetrics — Mon, 15 Mar 2010 17:54:49 +0100

Conclusion Serous borderline tumors of the fallopian tube are diagnosed in the third-fourth decade and are usually discovered incidentally during routine gynecologic examination or during an elective surgery. To date, there are no reports in the literature regarding recurrence or metastatic disease of STLMP of the fallopian tube. Conservative fertility-sparing surgery proved to be a safe and equally effective treatment for patients who wished to preserve their childbearing potential. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1410-8Authors Rita Abreu, Coimbra University Hospital Gynecology Department Praceta Dr. Mota Pinto 3000-075 Coimbra PortugalMarylin Dick, Aveiro District Hospital Gynecology Department Aveiro PortugalTeresa...

Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis

European Journal of Cancer — Mon, 08 Mar 2010 00:00:00 +0100

Abstract: Oxidative stress and antioxidant enzymes have been widely investigated in various carcinomas. However, there is only some information about their role in ovarian carcinogenesis or in ovarian carcinomas in vivo. We studied immunohistochemical nuclear and/or cytoplasmic expression of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and nitrotyrosine, as well as major antioxidative enzymes peroxiredoxins (PRDX) I–VI and thioredoxin (TXN) in ovarian tumours. The material consisted of 20 benign (10 serous, 10 mucinous) and 51 borderline (33 serous, 18 mucinous) epithelial ovarian tumours. The markers of oxidative stress, 8-OHdG and nitrotyrosine, were seen already in benign tumours (in 20% and 45% of the tumours, respectively) and their expression patterns were similar in b...

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Borderline serous papillary tumor arising in a paraovarian cyst

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Wed, 17 Feb 2010 00:00:00 +0100

Paraovarian cyst (PC) is a very common condition. However, tumors arising from PCs are very rare. A 45-year-old Japanese woman consulted our hospital because of abnormal bleeding. Imaging modalities including US, CT and MRI showed a cystic lesion (3.5cm in diameter) in the left adnexa (). MRI further identified a mural nodule measuring 0.8cm in diameter within the cystic lesion (). A cystectomy was performed under the clinical diagnosis of left ovarian malignancy. At operation, the cyst was a PC located in the mesosalpinx. It was remote from and did not attach to the ovary and fallopian tube. Frozen sections showed borderline serous papillary tumor within the PC. Further resection was not performed. The patient is now healthy 5 months after the operation. (Source: European Journal of Obst...

Inherited Determinants of Ovarian Cancer Survival.

Clinical Cancer Research — Tue, 26 Jan 2010 00:00:00 +0100

CONCLUSION: An extensive multiple-pathway assessment found evidence that inherited differences may play a role in outcome of ovarian cancer patients, particularly in genes within the angiogenesis and inflammation pathways. Our work supports efforts to target such mediators for therapeutic gain. Clin Cancer Res; 16(3); 995-1007. PMID: 20103664 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Biomolecular Pathogenesis of Borderline Ovarian Tumors: Focusing Target Discovery Through Proteogenomics.

Current Cancer Drug Targets — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Vergara D, Tinelli A, Martignago R, Malvasi A, Leo G Tumors of the epithelial surface account for about 80% of all ovarian neoplasms and exhibit a heterogeneous histological classification affecting survival. Tumors of low malignant potential, defined as borderline ovarian tumors (BOTs), have a markedly better survival and low recurrence, even if surgery still represents the common management for this type of cancer. It is still debated in the literature if BOTs can be considered as intermediate precursors in the progression to high grade ovarian tumors. Evidences now propose that high-grade serous carcinomas are not associated with a defined precursor lesion. Together with histopathological studies, mutations of KRAS, BRAF and p53 genes, microsatellite instability (MSI) and u...

Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance

Journal of Pediatric Surgery — Thu, 31 Dec 2009 15:18:28 +0100

Conclusion: By combining our series with 13 in the literature, a 1.8% malignancy rate occurred in 707 patients with ovarian torsion, markedly less than the reported malignancy rate of 10% in children with ovarian masses. Thus, neither a pathologic nor malignant lead point should be assumed in cases of torsion. In our series, which represents the largest series of torsion in the pediatric literature, all malignancies presented as stage I. These data further support the implementation of operative detorsion and close postoperative ovarian surveillance, with reoperation for persistent masses. Further study is needed to determine if delaying resection by weeks in those cases of persistent masses would result in tumor progression and thus change prognosis. (Source: Journal of Pediatric Surgery)

Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance.

Ai Zheng — Thu, 31 Dec 2009 11:48:59 +0100

Conclusion: The expression of OPN and B7-H4 increased in epithelial ovarian cancer, which could be referenced in the diagnosis of ovarian malignant tumors. PMID: 20038306 [PubMed - in process] (Source: Ai Zheng)

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Surgery in advanced borderline tumors

Fertility and Sterility — Fri, 25 Dec 2009 00:00:00 +0100

Our retrospective study evaluates the role of conservative surgery, performed in 10 of 22 patients affected by advanced stage serous borderline ovarian tumor. Although patients who underwent conservative surgery had a higher recurrence rate (60% after conservative surgery and 8% after radical surgery), all patients are alive without evidence of disease. (Source: Fertility and Sterility)

Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary

Annals of Oncology — Thu, 17 Dec 2009 12:55:12 +0100

Conclusions: This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of advanced-stage borderline ovarian tumors (with noninvasive implants) but the recurrence rate is high. Nevertheless, this high rate has no impact on survival. Conservative surgery can be proposed to patients with a borderline tumor of the ovary and noninvasive peritoneal implants. Should infertility persist following treatment of the borderline tumor, an in vitro fertilization procedure can be cautiously proposed. (Source: Annals of Oncology)

Recreational physical activity and risk of epithelial ovarian cancer

Cancer Causes and Control — Tue, 01 Dec 2009 21:02:38 +0100

Conclusions Our findings are compatible with an overall reduction in risk of invasive epithelial ovarian cancer associated with recreational activity but suggest that this association may differ in women with different histologic types of disease. Inconsistent findings across studies that have considered histologic type indicate that this issue is not yet resolved. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9479-8Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in E...

Nonpapillary Serous Cystadenoma of the Epididymis: Report of 2 Cases of a Rare Entity

Urology — Wed, 25 Nov 2009 00:00:00 +0100

Testicular and paratesticular tumors of the ovarian epithelial type have been well described in the published data. Since the seminal work by Young and Scully on 14 cases, several short series or isolated cases have been reported. All these tumors have been characterized by a benign indolent biological behavior, despite there also being cases of borderline and even malignant lesions of this type. Most reported cases have shown histopathologic features reminiscent of serous epithelial ovarian cystadenoma with papillary infoldings and nuclear stratification. In 2005, Pich and Galliano reported the first case of cystadenoma of the epididymis unassociated with any papillary growth, similar to some nonpapillary ovarian serous tumors. To the best of our knowledge, since this first report, only 2...

Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma

Human Pathology — Mon, 09 Nov 2009 00:00:00 +0100

Summary: Ovarian serous borderline tumor, micropapillary serous borderline tumor, and low-grade serous carcinoma often show a spectrum of histologic components with increasing epithelial proliferation and papillary complexity from flat cyst wall, hierarchical structures (with primary papillae branching into secondary papillae), micropapillae, and invasive carcinoma. Although tremendous research has been carried out to elucidate the causes of these tumors, the pathogenesis remains unclear. Literature has described a relationship between insufficient selenium intake and increased risk of cancer. The anticancer action of selenium has been suggested to be mediated by selenium-binding protein 1 as selenium-binding protein 1 is decreased in several cancers. The aim of the study was to examine by...

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Bilateral Ovarian Serous Borderline Tumor with a Giant Non-invasive Peritoneal Implant in a Four-Year-Old Girl

Journal of Pediatric and Adolescent Gynecology — Mon, 19 Oct 2009 00:00:00 +0100

We report a case of a 4-year-old premenarchal girl, previously healthy, who presented with two abdominal masses. Laboratory analysis of blood showed elevation of the serum level of the CA-125. Ultrasonographic examination disclosed bilateral cystic ovarian masses. Laparoscopic exploration revealed bilateral ovarian multicystic masses with retro-uterine peritoneal implant. Bilateral salpingo-oophorectomy with implant resection was performed. Histologic findings were consistent with a serous borderline tumors of both ovaries and the peritoneal implant was of the non-invasive type. There is no evidence of recurrence at 3-year follow-up.To our knowledge, there are only four cases of ovarian borderline tumors in premenarchal girls reported in the English literature: three of the mucinous type a...

Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathology

Diagnostic Histopathology — Mon, 12 Oct 2009 00:00:00 +0100

Abstract: Women may be genetically susceptible to development of gynecological cancers. Major familial ovarian cancer syndromes include site-specific ovarian cancer, breast/ovarian cancer, and hereditary non-polyposis colon cancer (HNPCC). The former two syndromes are linked to BRCA1 and BRCA2 genes while DNA repair genes such as hMSH2 and hMLH1 are commonly involved in HNPCC. Carriers are also prone to endometrial carcinoma. BRCA mutation related ovarian tumours are more likely to be high grade serous whilst borderline tumours are conspicuously absent. Papillary serous carcinomas of the peritoneum and fallopian tube are also reported. In recent years, serous tubal intraepithelial carcinoma and transitional metaplasia, its mimick, are identified at the fimbria of prophylactic salpingo-ooph...

[Peritoneal serous borderline tumor discovered during a cesarean section. A case report.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Thu, 08 Oct 2009 23:00:00 +0100

Authors: Raiga J, Ben Abdelkrim S, Dupré F, Treisser A During a caesarean section performed in a 36-year-old woman, we discovered small granulations on the pelvic peritoneum. Biopsies were performed. The diagnosis of primitive borderline serous tumor was confirmed by pathologists. The patient was operated twice: once for diagnostic evaluation, and again six months later. A radical gesture was then decided for therapeutic purposes. The optimal attitude regarding these borderline peritoneal tumors in young women remains difficult and requires a multidisciplinary workout between pathologists and surgeons. PMID: 19819645 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Breastfeeding and risk of epithelial ovarian cancer

Cancer Causes and Control — Thu, 24 Sep 2009 16:48:11 +0100

Conclusions A long total duration of breastfeeding appears to be associated with a substantial reduction in the overall risk of ovarian cancer, independent of the decrease in risk due to childbirth, but this may vary according to histological subtype. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9440-xAuthors Susan J. Jordan, The University of Queensland School of Population Health Public Health Building, Herston Rd Herston, Brisbane 4006 AustraliaVictor Siskind, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaAdèle C Green, The Queensland Institute of Medical Research Genetics and Population Health Division Brisbane AustraliaDavid C. Whiteman, The Queensland Institute of Medical Resea...

Conservative resection for benign tumors of the proximal pancreas.

World Journal of Gastroenterology : WJG — Thu, 27 Aug 2009 23:00:00 +0100

CONCLUSION: CR is a safe and effective procedure for patients with benign tumors in the proximal pancreas, with careful CCI-PJ and postoperative MCCL. PMID: 19705501 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic Problems

Advances in Anatomic Pathology — Wed, 26 Aug 2009 12:37:27 +0100

Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors are indolent and have better outcome than high-grade tumors. In contrast, high-grade serous carcinomas have high-grade nuclei and numerous mitotic figures. Identification...

Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary.

Ann Oncol — Wed, 15 Jul 2009 23:00:00 +0100

CONCLUSIONS: This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of advanced-stage borderline ovarian tumors (with noninvasive implants) but the recurrence rate is high. Nevertheless, this high rate has no impact on survival. Conservative surgery can be proposed to patients with a borderline tumor of the ovary and noninvasive peritoneal implants. Should infertility persist following treatment of the borderline tumor, an in vitro fertilization procedure can be cautiously proposed. PMID: 19608617 [PubMed - as supplied by publisher] (Source: Ann Oncol)

Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review

Archives of Gynecology and Obstetrics — Tue, 14 Jul 2009 09:56:47 +0100

Conclusion The existence of sarcomatous nodules combined with the SLMN necessitates a careful histologic analysis for treatment and the determination of prognosis. However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1180-3Authors Tayfun Gungor, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gynecologic Oncology Department Ankara TurkeyS. Ozlem Altınkaya, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Gynecologic Oncology Department Ankara TurkeySerap Akbay, Zekai Tahir Burak Women’s Health Care Education and Research Hospital Pathology Department Ankara TurkeyUmıt Bı...

Clinicopathological significance of DEK overexpression in serous ovarian tumors

Pathology International — Sun, 21 Jun 2009 23:00:00 +0100

To investigate the significance of DEK protein expression in ovarian lesions, a total of 113 ovarian serous tumors, including 62 serous cystadenocarcinomas and 19 serous borderline tumors, were studied on immunohistochemistry. For comparison, 32 benign serous tumors, including 12 serous papillary cystadenomas, 10 serous cystadenomas, and 10 serous surface papillomas, were also included. DEK was positive in 93.5% of serous cystadenocarcinomas (58/62), 63.2% of serous borderline tumors (12/19), and weakly positive in 15.6% of benign serous tumors (5/32). The strong positive signal was detected only in serous adenocarcinomas (80.6%, 50/62) and borderline tumors (21.1%, 4/19), but no serous benign tumors were strongly positive (0%, 0/32). Meanwhile, the strong positivity rate of DEK protein wa...

The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia.

International Journal of Oncology — Sun, 31 May 2009 23:00:00 +0100

This study investigated the expression patterns of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor (MIS/AMHRII) and mRNA in various types of ovarian neoplasia and evaluated the clinical significance of MIS/AMH as a biological response modifier for MIS/AMHR-positive tumors. Reverse transcriptase polymerase chain reaction was used to detect MIS/AMHRII mRNA expression and in situ hybridization and immunohistochemistry were used to localize MIS/AMHRII mRNA and protein expression. The degree of expression was scored from 0 (no staining) to 3 (strong staining). There was no significant difference in expression intensity between MIS/AMHRII protein and mRNA on all ovarian samples whether benign or malignant. MIS/AMHRII protein and mRNA were weakly expressed on 45.4...

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Prognostic factors in patients with ovarian serous low malignant potential (borderline) tumors with peritoneal implants.

The Oncologist — Sun, 31 May 2009 23:00:00 +0100

The objective of this study was to determine prognostic factors in a large series of patients with stage II or III serous low malignant potential ovarian tumor (LMPOT) and peritoneal implants. Methods. Patients with a serous LMPOT and peritoneal implants treated at or referred to our institution were retrospectively reviewed. The slides of ovarian tumors and peritoneal implants were reviewed by the same pathologist. Results. From 1969 to 2006, 168 patients were reviewed, 21 of whom had invasive implants. Tumors exhibited a micropapillary pattern in 56 patients. Adjuvant treatment had been administered to 61 patients. The median duration of follow-up was 57 months (range, 1-437). Forty-four patients had relapsed and 10 patients had died. The 5-year overall survival rate was 98%. Among patie...

[Diagnostic problems of ovarian mucinous borderline tumors.]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is good, but they are resistant to the traditional chemotherapies. To diagnose the intraepithelial carcinoma, to detect the microinv...

[Diagnostic problems of ovarian mucinous borderline tumors]

Magyar Onkologia — Sun, 31 May 2009 23:00:00 +0100

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumors

Basic and Applied Pathology — Mon, 18 May 2009 04:00:00 +0100

Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)

Expression of Hyaluronan Synthases (HAS1-3) and Hyaluronidases (HYAL1-2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

BMC Cancer — Tue, 12 May 2009 04:00:00 +0100

Conclusion: The results indicate that in serous epithelial ovarian malignancies HAS expression is not consistently elevated but HYAL1 expression is significantly reduced and correlates with the accumulation of hyaluronan. (Source: BMC Cancer)

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Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas—an image cytometric DNA ploidy analysis of 307 cases with histogenetic implications

Virchows Archiv — Thu, 07 May 2009 05:53:38 +0100

Abstract Our objective was to study the gross genomic alterations in serous borderline tumors and serous adenocarcinomas of the ovary. A retrospective analysis of 245 serous borderline tumors and 62 serous adenocarcinomas from 249 patients was performed using high-resolution image cytometric DNA ploidy analysis. DNA ploidy status, S-phase fraction, and DNA index were evaluated. The majority of serous borderline tumors were diploid (225/245 cases, 92%). The remaining 8% showed an aneuploid peak predominantly with DNA index of less than 1.4. Grades 2 and 3 serous adenocarcinomas were more often (80%) nondiploid, mostly with DNA index exceeding 1.4. Grade 1 serous adenocarcinomas were an intermediate group, more similar to serous borderline tumors. The S-phase fraction increa...

Results after conservative treatment of serous borderline tumours of the ovary with stromal microinvasion but without micropapillary pattern.

BJOG : An International Journal of Obstetrics and Gynaecology — Thu, 30 Apr 2009 23:00:00 +0100

This study suggests that conservative treatment of SBOT-SMI is safe. PMID: 19432576 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-Grade and High-Grade Carcinomas

Cancer Research — Thu, 30 Apr 2009 04:00:00 +0100

Ovarian serous carcinoma, the most common and lethal type of ovarian cancer, is thought to develop from two distinct molecular pathways. High-grade (HG) serous carcinomas contain frequent TP53 mutations, whereas low-grade (LG) carcinomas arise from serous borderline tumors (SBT) and harbor mutations in KRAS/BRAF/ERBB2 pathway. However, the molecular alterations involved in the progression from SBT to LG carcinoma remain unknown. In addition, the extent of deletion of tumor suppressors in ovarian serous carcinomas has not been well studied. To further address these two issues, we assessed DNA copy number changes among affinity-purified tumor cells from 37 ovarian serous neoplasms including SBT, LG, and HG tumors using high-density 250K single nucleotide polymorphism arrays. Chromosomal inst...

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors

Pathology International — Tue, 21 Apr 2009 04:00:00 +0100

Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage. The numbers of CD68-positive macrophages as well as of CD163- and CD204-positive...

Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms

Human Pathology — Tue, 14 Apr 2009 23:00:00 +0100

In conclusion, hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms because (1) clear cell carcinoma and serous borderline tumor do not coexist and (2) hobnail-like cells in clear cell carcinoma and serous borderline tumor are immunophenotypically distinct. Recognition of our conclusion may protect a patient with “conspicuous hobnail-like cells in serous borderline tumor” from an erroneous overdiagnosis of “concomitant clear cell carcinoma admixed with serous borderline tumor.” (Source: Human Pathology)

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Occurrence of Two Rare Malignant Neoplasms (Breast and Ovarian) in an Adolescent Female

Journal of Pediatric and Adolescent Gynecology — Wed, 08 Apr 2009 23:00:00 +0100

Abstract: Background: Phyllodes breast tumors, particularly malignant ones, are rare in adolescents. Tumor behavior does not correlate with histopathology. This case of an adolescent with a malignant phyllodes tumor, followed by the occurrence of a borderline ovarian tumor, also uncommon in adolescence, may shed light on our understanding of phyllodes and uncommon gynecologic malignancies in the young.Case: A-14 year-old Caucasian female underwent wide local excision of a 4-cm malignant phyllodes breast tumor. At 17 years of age she had excision of a serous borderline tumor of the ovary.Comments: The occurrence of two rare neoplasms in an adolescent female raises questions about a common underlying etiology, such as a genetic mutation. Genetic evaluation of minors is a sensitive and comple...

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.

Gynecologic Oncology — Mon, 09 Mar 2009 04:00:00 +0100

CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors

Human Pathology — Mon, 09 Mar 2009 00:00:00 +0100

Summary: Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to serous borderline tumor or low-grade endometrioid tumor than to gastrointestinal mucinous borderline tumor by directly co...

MRI appearances of borderline ovarian tumours.

Clinical Radiology — Sun, 08 Mar 2009 18:36:34 +0100

Authors: Bent CL, Sahdev A, Rockall AG, Singh N, Sohaib SA, Reznek RH This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tumour. A history of a metachronous mucinous borderline tumour was identified in one patient. MRI appea...

Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors.

Human Pathology — Fri, 06 Mar 2009 05:00:00 +0100

Authors: Yasunaga M, Ohishi Y, Oda Y, Misumi M, Iwasa A, Kurihara S, Nishimura I, Okuma E, Kobayashi H, Wake N, Tsuneyoshi M Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with serous borderline tumor. Furthermore, some investigators have explained the histogenesis of mullerian mucinous borderline tumor by metaplastic and hyperplastic transformation of endometriosis (Fukunaga M, Ushigome S. Epithelial metaplastic changes in ovarian endometriosis. Mod Pathol. 1998;11:784-788). The purpose of this study is to substantiate the concept that mullerian mucinous borderline tumor is histogenetically closer to s...

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[Diagnostic difficulties of serous borderline tumors of the ovary.]

Magyar Onkologia — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential). They represent a common diagnostic and treatment problem both for the pathologist and for clinicians. The borderline tumors occur most commonly in childbearing age, show an indolent course and have good prognosis but are resistant to the traditional chemotherapies. The serous borderline tumors are the most common types of borderline ovarian tumors and they can cause differential diagnostic problems even for the experienced pathologist. We studied 30 cases which were diagnosed in our institute from 2000 to 2008. Thirteen were typical serous borderline tumors, in 7 cases the pattern was micropapillary, in 2 cases with...

Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients.

Gynecologic Oncology — Mon, 02 Feb 2009 05:00:00 +0100

CONCLUSIONS: Maspin is upregulated in borderline tumors and the early stages of ovarian carcinoma and then significantly downregulated with malignant transformation. High expression may paradoxically promote the invasion and metastasis of ovarian carcinomas. Our study revealed that maspin expression could play an important role in predicting the results of treatment of ovarian cancer patients. PMID: 19193429 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Paratubal borderline serous tumors.

Gynecologic Oncology — Sun, 01 Feb 2009 05:00:00 +0100

CONCLUSION: Borderline fallopian tube or paratubal tumors are usually early stage at diagnosis and commonly present in the third decade with pain or are discovered on routine examination. Continued reporting of these tumors is essential to understanding the prognosis and treatment of this rare tumor. PMID: 19189870 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases

Archives of Gynecology and Obstetrics — Fri, 19 Dec 2008 08:15:15 +0100

We present a case of 45-year-old woman with ovarian psammocarcinoma who initially presented with a metastatic subcutaneous nodule, and was found to have pulmonary and mediastinal metastases. We believe this to be the first report of a psammocarcinoma with these metastases. Ovarian and peritoneal psammocarcinomas are quite rare, and because of this, knowledge of their behavior is limited. Although most seem to follow an indolent course similar to that of borderline lesions of the ovary, this case demonstrates that some of these tumors may be clinically aggressive with distant metastases. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0883-1Authors Daniel M. Chase, Western Reserve Care System/Northeast Ohio Universities College of Medicine Department of Surge...

[Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]

Cirugia eEspanola — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, Lladó L, Valls C, Serrano T, Rafecas A Management of the cystic lesions of the pancreas is of interest to general and pancreatic surgeons and physicians of other disciplines: gastroenterology, internal medicine, endoscopy, radiology, pathology, etc. The majority of cystic lesions are inflammatory pseudo-cysts. Cystic neoplasms represents only 10% of cystic lesions of the pancreas and 1% of pancreatic tumours. Preoperative diagnosis is crucial given the differences in natural history of the spectrum of benign, malignant, and borderline lesions. Serous cystadenoma is a benign lesion that requires non-surgical management if there are no symptoms. Mucinous neoplasms are premalignant lesions that mainly require pa...

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Immunohistochemical profiling of benign, low malignant potential and low grade serous epithelial ovarian tumors

BMC Cancer — Wed, 26 Nov 2008 05:00:00 +0100

Conclusions: This study represents an extensive analyse of the benign and highly differentiated ovarian disease from an immunohistochemical perspective. (Source: BMC Cancer)

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.

International Journal of Oncology — Sun, 23 Nov 2008 10:41:33 +0100

In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology. PMID: 19020757 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study

BMC Cancer — Sun, 16 Nov 2008 05:00:00 +0100

Conclusion: Our report confirms the prognostic value of HIF-1a when restricted to poorly differentiated serous ovarian carcinoma. In addition it shows that this association is elusive, since it is not only methodology-related but it can be antibody-depended. There is adequate evidence to speculate that targeting HIF-1a could improve the long-term prognosis of these patients In order to increase the overall sensitivity of the immunoassay, maintaining acceptable levels of specificity, a panel of antibodies should be used. (Source: BMC Cancer)

Serous and seromucinous infantile ovarian cystadenomas-A study of 42 cases.

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Fri, 07 Nov 2008 05:00:00 +0100

Authors: Massicot R, Rousseau V, Darwish AA, Sauvat F, Jaubert F, Nihoul-Fékété C The rarity of infantile ovarian cystadenoma (CA) accounts for the very little knowledge about their behaviour. The aim of this retrospective study is to highlight the modes of presentation and to evaluate the treatments and the recurrence risks of these benign tumours. Relation to adult epithelial ovarian tumours is discussed. The medical records and imaging studies of 42 CA in 31 children less than 16 years of age operated at our institution between 1985 and 2003 were retrospectively evaluated. Mean age of first surgery was 11 and 5 years. 7/31 (22, 6%) girls presented with a bilateral CA, four of them were synchronous. 8/42 (19%) CA were in torsion at surgery, conservative management was ...

Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors

Basic and Applied Pathology — Tue, 04 Nov 2008 05:00:00 +0100

Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)

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Serous borderline ovarian tumors in long‐term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas

International Journal of Gynecological Cancer — Sat, 01 Nov 2008 00:00:00 +0100

Abstract (Source: International Journal of Gynecological Cancer)

Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer.

International Journal of Oncology — Sun, 26 Oct 2008 12:12:05 +0100

Authors: Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We investigated nm23-H1, AKT and pAKT expression by using immunohistochemical staining in ovarian clear cell adenocarcinoma, ovarian benign, borderline and malignant serous tumors and analyzed their relationship with prognostic factors. Using ES-2 and SKOV-3 ovarian cancer cell lines, we studied the modulation of estrogen and progestin on cell migration and invasion as well as their effect on AK...

Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1

Archives of Gynecology and Obstetrics — Tue, 21 Oct 2008 06:12:08 +0100

Conclusion Hypoxic state was considered to be closely related to histological type of epithelial ovarian tumors, suggesting that CLAs may be most hypoxic. In the comparison of mucinous tumors, malignancies would not always become most hypoxic. Tumor size may not be strongly associated with hypoxic state. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0816-zAuthors Masaki Miyazawa, Tokai University Department of Pathology, School of Medicine Tokyo JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane Hidaka Saitama 350-1298 JapanMariko Fujita, Tokai University Department of Pathology, School of Medicine Tokyo JapanTakeshi Hirasawa, Tokai University Department of Obstetrics and Gy...

RUNX3 protein is overexpressed in human epithelial ovarian cancer.

Gynecologic Oncology — Sat, 18 Oct 2008 04:00:00 +0100

CONCLUSION: These results suggest that RUNX3 has a role in cell proliferation and viability in ovarian cancer. PMID: 18937968 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Results After Conservative Treatment of Serous Borderline Tumors of the Ovary with a Micropapillary Pattern

Annals of Surgical Oncology — Sat, 27 Sep 2008 13:35:57 +0100

Conclusion This study demonstrates that spontaneous pregnancies can be achieved after conservative treatment of SBOT-MP. Nevertheless, as 2/3 of patients had bilateral ovarian involvement at the time of initial management, the recurrence rate is high. However, making definitive conclusions about the safety of conservative surgery is limited by the small sample size. So, further studies are warranted to evaluate conservative management of advanced-stage disease. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-008-0159-9Authors Isabelle Laurent, Institut Gustave-Roussy Service de Chirurgie Gynécologique 39 rue Camille-Desmoulins 94805 Villejuif Cedex FranceCatherine Uzan, Institut Gustave-Roussy Service de Chirurgie Gynécologique 39 rue Ca...

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A Comparative Analysis of Lymphatic Vessel Density in Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors) With and Without Lymph Node Involvement.

International Journal of Gynecological Pathology — Sat, 20 Sep 2008 09:56:39 +0100

Page: 483DOI: 10.1097/PGP.0b013e3181742d7cAuthors: Fadare, Oluwole M.D.; Orejudos, Michael P. M.D.; Jain, Reena M.D.; Mariappan, M. Rajan M.D., Ph.D.; Hecht, Jonathan L. M.D., Ph.D.; Renshaw, Idris L. M.D., Ph.D.; Hileeto, Denise M.D.; Wang, Sa A. M.D.; Ghofrani, Mohiedean M.D.; Liang, Sharon X. M.D., Ph.D. (Source: International Journal of Gynecological Pathology)

Accuracy of intraoperative frozen section in the diagnosis of ovarian tumors

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Fri, 29 Aug 2008 04:00:00 +0100

Conclusion: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary

BMC Cancer — Sun, 24 Aug 2008 04:00:00 +0100

Conclusion: The present pilot study demonstrates that the GIPC1 protein is overexpressed in ovarian and breast cancer, which may provide an important diagnostic and prognostic marker and will constitute the basis for further study of the role that this protein plays in malignant diseases. In addition, this study suggests that human monoclonal antibodies 27.F7 and 27.B1 should be further evaluated as potential diagnostic tools. (Source: BMC Cancer)

Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery

Cancer Causes and Control — Fri, 15 Aug 2008 07:10:36 +0100

Conclusions Our results suggest differences in the relation of ovarian cysts and endometriosis with risk of specific subtypes of ovarian cancer as well as the possibility that ovarian surgery in women with these conditions may lower the risk of invasive disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9207-9Authors Mary Anne Rossing, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKara L. Cushing-Haugen, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAKristine G. Wicklund, Fred Hutchinson Cancer Research Center Program in Epidemiology P.O. Box 19024 Seattle WA 98108-1024 USAJennifer A. Doherty, Fred Hutchinson Cancer Researc...

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.

Gynecologic Oncology — Sat, 02 Aug 2008 04:00:00 +0100

CONCLUSION: Downregulation or inactivation of p53, Rb and/or PP2A plays a role in the progression from SBOT to invasive ovarian carcinomas. PMID: 18678400 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference

BioMed Central — Mon, 28 Jul 2008 04:00:00 +0100

The objective of this study was to examine mtDNA sequence variants in 118 frozen tissues of three subtypes of epithelial ovarian cancer (serous, n=48 endometrioid, n=47 and mucinous, n =23) and matched paracancerous normal tissues (n= 18) in relation to racial/ethnic and age differences. Restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-based sequencing were used to evaluate two regions of mtDNA spanning 5317 to 7608 and 8282 to 10110 bp and including ND subunits 2, 3, MT-COI, II, and III, ATPase 8, a part of ATPase 6, and tRNA genes in frozen ovarian tissues obtained from the southern regional Cooperative Human Tissue Network (CHTN) and University of Alabama-Birmingham (UAB) Ovarian Spore Center. Thirty-nine mtDNA variants were detected of which 28 were p...

Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.

Cancer Control — Sat, 14 Jun 2008 20:37:38 +0100

We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no associ...

Distribution of microsatellite instability in Danish ovarian tumor patients and the prognostic value in ovarian cancer patients.

Oncology Research — Wed, 21 May 2008 17:00:11 +0100

In conclusion, we found no association to any of the clinical parameters evaluated, although a tendency of a higher frequency of MSI was observed among serous OC. PMID: 18488714 [PubMed - in process] (Source: Oncology Research)

Body size and risk of epithelial ovarian and related cancers: A population-based case-control study

International Journal of Cancer — Wed, 30 Apr 2008 04:00:00 +0100

Laparoscopy-assisted cystectomy for large adnexal cysts

Archives of Gynecology and Obstetrics — Wed, 23 Apr 2008 16:16:55 +0100

Conclusion Laparoscopy-assisted surgery is feasible and safe for women with large benign adnexal cysts and result s in a short surgery time. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-008-0651-2Authors Ahmet Göçmen, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyTuba Atak, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyMustafa Uçar, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul TurkeyFatih Şanlıkal, Ümraniye Education and Research Hospital Departments of Obsterics and Gynecology Istanbul Turkey Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Sour...

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Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis

World Journal of Surgical Oncology — Tue, 22 Apr 2008 04:00:00 +0100

Conclusion: Early surgical intervention, together with careful surveillance and follow-up, can achieve successful long-term outcomes in patients with this rare malignancy. (Source: World Journal of Surgical Oncology)

Serous borderline tumor of the paratestis

Pathology International — Mon, 21 Apr 2008 13:09:38 +0100

Pathology International, Volume 58, Issue 5, Page 311-316, May 2008. Reported herein is a case of serous borderline tumor (SBT, ovarian epithelial type tumor) of the paratestis, involving the tunica vaginalis, in a 64-year-old man. The patient complained of right hydrocele; puncture cytology of the turbid fluid pointed to ... (Source: Pathology International)

Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas

Journal of Hepato-Biliary-Pancreatic Surgery — Sun, 06 Apr 2008 07:00:03 +0100

Conclusions Duodenum-preserving total pancreatic head resection for IPMN, MCN, serous cystadenoma (SCA), and cystic EN lesions is a safe and beneficial surgical procedure. Segmental resection of the duodenum was applied for an oncologically complete resection. In regard to long-term outcome, the procedure is, additionally, a pancreatic cancer preventive strategy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00534-007-1227-4Authors Hans G. Beger, c/o Universitätsklinikum Ulm Steinhövelstrasse 9 D-89075 Ulm GermanyFrank Gansauge, Department of Visceral Surgery Donau-Klinik Neu-Ulm GermanyMarko Siech, Department of General-, Vascular-and Visceral Surgery Ostalb Klinikum Aalen GermanyMichael Schwarz, Department of Visceral Surgery Donau-Klinik Neu-U...

Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors.

Yonsei Medical Journal — Tue, 01 Apr 2008 04:00:00 +0100

Conclusion: MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon in sporadic ovarian tumors, even by using additional MSI markers. The clinical significance of MSI is not strong in patients with sporadic ovarian tumors. PMID: 18452265 [PubMed - in process] (Source: Yonsei Medical Journal)

Retinoid Receptor Alpha and Beta Expression in Serous Ovarian Tumors.

Oncology — Wed, 12 Mar 2008 04:00:00 +0100

Authors: Daponte A, Kostopoulou E, Chiotoglou I, Vanakara P, Minas M, Nakou M, Kallitsaris A, Kollia P, Koukoulis G, Messinis IE The expression of retinoid acid receptors alpha (RARalpha) and beta (RARbeta) and estrogen receptor alpha (ERalpha) was assessed by immunohistochemistry and Western blotting in normal ovaries, serous cystadenoma (n = 20), serous borderline (n = 14), and serous ovarian cancer (n = 47) and was correlated in cancer cases with stage, grade, progress-free survival (PFS), and survival. RARalpha was increasingly expressed in benign cystadenomas, borderline, and low-stage and advanced-stage neoplasms (p < 0.001). In stage III, G3 serous carcinoma, increased RARalpha expression was an independent prognostic factor associated with lower chemoresponse to first-line c...

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Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms.

Gynecologic Oncology — Sat, 08 Mar 2008 05:00:00 +0100

CONCLUSIONS: CEACAM6 is overexpressed in borderline and invasive MON's. PMID: 18331757 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Human papilloma virus (HPV) status, p16(INK4a), and p53 overexpression in epithelial malignant and borderline ovarian neoplasms.

Pathology, Research and Practice — Mon, 25 Feb 2008 10:06:14 +0100

Authors: Giordano G, Azzoni C, D'Adda T, Rocco A, Gnetti L, Froio E, Merisio C, Melpignano M This investigation is the first to evaluate simultaneously human papilloma virus (HPV) status, p16(INK4a), and p53 immunoreactivity in epithelial ovarian neoplasms. The results were analyzed and correlated with histological type, histological grade, and survival of patients. Subtypes considered are papillary serous and mucinous. Polymerase chain reaction (PCR) analysis, performed in our previous study, had already demonstrated a small number of HPV-positive epithelial ovarian neoplasms. No significant correlation was found between the presence of HPV DNA and subtypes of ovarian neoplasms; thus, HPV cannot be considered responsible for epithelial ovarian neoplasm. Since p16 immunoreactivity was ...

[My approach] My approach to and thoughts on the typing of ovarian carcinomas

Journal of Clinical Pathology — Fri, 25 Jan 2008 05:00:00 +0100

Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the distinction between high-grade serous and endometrioid adenocarcinomas and the distinction between a true clear cell carcinoma and clear cell areas within other adenocarcinom...

Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas

International Journal of Gynecological Cancer — Wed, 23 Jan 2008 21:37:08 +0100

International Journal of Gynecological Cancer, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Woo MMM, Salamanca CM, Miller M, Symowicz J, Leung PCK, Oliveira C, Ehlen TG, Gilks CB, Huntsman D, Auersperg N. Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas. Int J Gynecol ... (Source: International Journal of Gynecological Cancer)

Defining an Appropriate Threshold for the Diagnosis of Serous Borderline Tumor of the Ovary: When Is a Full Staging Procedure Unnecessary?

International Journal of Gynecological Pathology — Sat, 22 Dec 2007 01:39:58 +0100

Page: 10DOI: 10.1097/pgp.0b013e318133a9b7Authors: Allison, Kimberly H. M.D.; Swisher, Elizabeth M. M.D.; Kerkering, Katrina M. M.D.; Garcia, Rochelle L. M.D. (Source: International Journal of Gynecological Pathology)

Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-alpha.

Acta Histochemica — Sat, 01 Dec 2007 05:00:00 +0100

In this study, we compared the immunoreactivities of TGF-alpha and EGF-R in ovarian tumors and related immunohistochemical findings to the histological type of the tumors. Formalin-fixed, paraffin wax-embedded tissue sections from 40 patients who had serous-mucinous borderline tumor and serous-mucinous adenocarcinoma of the ovary (n=10 each) were stained with hematoxylin-eosin and labeled for binding of primary antibodies against TGF-alpha and EGF-R using an avidin-biotin-peroxidase method. A semi-quantitative grading system was used to compare immunohistochemical labeling intensities. Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-alpha was detected in adenocarcinomas. There was no significant difference in the immunoreactivity of TGF-alpha among the histologic t...

Hypoxic status in ovarian serous and mucinous tumors: relationship between histological characteristics and HIF-1α/GLUT-1 expression

Archives of Gynecology and Obstetrics — Tue, 20 Nov 2007 15:24:05 +0100

Conclusion HIF-1α and GLUT-1 expressions seemed to be coordinated to adapt ovarian tumor cells into hypoxic conditions in close association with the acquisition of malignancy. We consider that the relatively strong expression of both markers in serous tumors compared with mucinous tumors is related to the difference in their histological characteristics. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-007-0500-8Authors Tetsuji Iida, Tokai University School of Medicine Department of Obstetrics and Gynecology Kanagawa JapanMasanori Yasuda, Saitama Medical University International Medical Center Department of Pathology 1397-1 Yamane, Hidaka Saitama 350-1298 JapanMasaki Miyazawa, Tokai University School of Medicine Department of Pathology Kanagawa JapanMarik...

[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]

Chinese Journal of Cancer — Thu, 01 Nov 2007 04:00:00 +0100

CONCLUSION: The expression of GLUT-1 and the loss of DNA-PKcs may be closely related to the malignant transformation of serous ovarian tumors. PMID: 17991316 [PubMed - in process] (Source: Chinese Journal of Cancer)

The differential diagnosis of primary peritoneal papillary tumors

Archives of Gynecology and Obstetrics — Wed, 10 Oct 2007 16:10:35 +0100

Summary Primary tumors of the peritoneum are rare. Histological differentiation between papillary mesotheliomas, primary ovarian tumors, borderline tumors of the ovary with peritoneal deposits and primary peritoneal carcinoma may be difficult. The expression of vimentin, keratin, pankeratin, CEA, CA125, CA19-9, S100, B 72.3 and BerEP4 was therefore investigated in twelve women with primary malignant peritoneal tumors, twelve women with pleural mesothelioma, eight women with serous ovarian carcinoma and four men with peritoneal mesothelioma. The marker pattern we used was no help in differentiating between metastatic ovarian carcinoma and primary peritoneal carcinomatosis. A combination of the markers S100, B 72.3 and BerEP4 helped the distinction between mesotheliomas and ...

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Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

International Journal of Cancer — Thu, 04 Oct 2007 04:00:00 +0100

Sarcomatoid carcinoma arising within a serous borderline ovarian tumour: a case report and practical approach to differential diagnosis

Histopathology — Fri, 28 Sep 2007 12:01:52 +0100

Histopathology Volume 0, Issue 0, Page ???-???. (Source: Histopathology)

Primary peritoneal serous borderline tumor presenting as an "adnexal torsion" gynecologic emergency.

Taiwanese Journal of Obstetrics and Gynecology — Sat, 01 Sep 2007 04:00:00 +0100

PRIMARY PERITONEAL SEROUS BORDERLINE TUMOR PRESENTING AS AN "ADNEXAL TORSION" GYNECOLOGIC EMERGENCY. Taiwan J Obstet Gynecol. 2007 Sep;46(3):308-310 Authors: Lin PY, Ueng SH, Tseng MJ PMID: 17962119 [PubMed - as supplied by publisher] (Source: Taiwanese Journal of Obstetrics and Gynecology)

Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumours

Histopathology — Tue, 21 Aug 2007 12:04:14 +0100

Histopathology Volume 51, Issue 3, Page 313-321, Sep 2007. Stewart C J R, Brennan B A, Crook M L & Russell P(2007) Histopathology 51, 313–321Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumoursAims: To determine whether elastin stains aid in classifyi... (Source: Histopathology)