MedWorm: Borderline Tumor

Encapsulated papillary thyroid carcinoma, follicular variant: A misnomer

Pathology International — Mon, 30 Jan 2012 05:00:00 +0100

In conclusion, a malignant diagnosis of EnFVPTC should not be used to cover this spectrum of tumors until uncertainty about the nature of this lesion is settled, whether it is benign, precancerous or malignant. (Source: Pathology International)

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MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors

Journal of Neuro-Oncology — Fri, 27 Jan 2012 17:56:38 +0100

The objective of this study was to retrospectively investigate MGMT promoter hypermethylation status for a series of 350 human brain tumors, including 275 gliomas of different malignancy grade, 21 glioblastoma multiforme (GBM) cell lines, and 75 non-glial tumors. The analysis was performed by methylation-specific PCR and capillary electrophoresis. MGMT expression at the protein level was also evaluated by both immunohistochemistry (IHC) and western blotting analysis. Associations of MGMT hypermethylation with IDH1/IDH2 mutations, EGFR amplification, TP53 mutations, and 1p/19q co-deletion, and the prognostic significance of these, were investigated for the gliomas. MGMT promoter hypermethylation was identified in 37.8% of gliomas, but was not present in non-glial tumors, with the excepti...

Loss of E‐cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma

APMIS — Mon, 23 Jan 2012 05:00:00 +0100

In this study, the expression of E‐cadherin was evaluated in CRC to determine its correlation with clinico‐pathological variables, and association with disease outcome in patients with long‐term follow‐up. The present series consisted of tissue samples obtained from 230 patients with stage I, II, III, or IV CRC treated during 1981–1990 at Turku University Hospital. Archival paraffin‐embedded samples were used to build up tissue microarray blocks, and E‐cadherin expression was assessed by immunohistochemistry using an automated staining system. Different grading systems were tested for expression of E‐cadherin. Fifty‐nine percent of all tumors were positive for E‐Cadherin. There was no significant correlation between E‐cadherin expression and gender (p < 0.83), ...

Changes in immunomodulatory constituents of human milk in response to active infection in the nursing infant.

Pediatric Research — Fri, 20 Jan 2012 23:36:12 +0100

Discussion:During active infection in nursing infants, the total number of white blood cells, specifically the number of macrophages, and TNFα levels increase in their mothers' breast milk. These results may support the dynamic nature of the immune defense provided by breastfeeding sick infants.Methods:Breast milk from mothers of 31 infants, up to 3 months of age, who were hospitalized with fever, was sampled during active illness and recovery. Milk from mothers of 20 healthy infants served as controls. PMID: 22258136 [PubMed - in process] (Source: Pediatric Research)

Defined Clinical Classifications Are Associated with Outcome of Patients with Anatomically Resectable Pancreatic Adenocarcinoma Treated with Neoadjuvant Therapy

Annals of Surgical Oncology — Thu, 19 Jan 2012 07:00:34 +0100

Conclusions This system describes discrete clinical subgroups of patients with pancreatic cancer who have similar, potentially resectable tumor anatomy but heterogeneous physiology and cancer biology. It may be used with neoadjuvant therapy to predict outcomes, individualize treatment algorithms, and optimize survival. Content Type Journal ArticleCategory Pancreatic TumorsPages 1-9DOI 10.1245/s10434-011-2211-4Authors Ching-Wei D. Tzeng, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAJason B. Fleming, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAJeffrey E. Lee, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAL...

The value of frozen section evaluation in the management of borderline ovarian tumors

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: In the frozen section evaluation of BOTs, the underdiagnosis that restricts the diagnostic performance of the method seems to be a major problem. A more careful approach is therefore needed, while choosing a proper surgical technique during laparotomy for ovarian masses. In order to reduce the false diagnosis and surgical morbidity, the frozen section analysis should be applied by experienced pathologists and the possible predictive factors affecting a false diagnosis should carefully be taken into consideration. (Source: Journal of Cancer Research and Therapeutics)

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Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial

Acta Neuropathologica — Tue, 17 Jan 2012 07:11:19 +0100

Abstract Glioblastoma (GBM) is a morphologically heterogeneous tumor type with a median survival of only 15 months in clinical trial populations. However, survival varies greatly among patients. As part of a central pathology review, we addressed the question if patients with GBM displaying distinct morphologic features respond differently to combined chemo-radiotherapy with temozolomide. Morphologic features were systematically recorded for 360 cases with particular focus on the presence of an oligodendroglioma-like component and respective correlations with outcome and relevant molecular markers. GBM with an oligodendroglioma-like component (GBM-O) represented 15% of all confirmed GBM (52/339) and was not associated with a more favorable outcome. GBM-O encompassed a...

Pylorus- and spleen-preserving total pancreatoduodenectomy with resection of both whole splenic vessels: feasibility and laparoscopic application to intraductal papillary mucin-producing tumors of the pancreas

Surgical Endoscopy — Thu, 12 Jan 2012 06:41:01 +0100

Conclusions PpSpTPD with segmental resection of both splenic vessels is feasible and safe. Even a minimally invasive approach can be indicated in selected patients. Content Type Journal ArticleCategory Dynamic ManuscriptPages 1-6DOI 10.1007/s00464-011-2113-3Authors Sung Hoon Choi, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaHo Kyoung Hwang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaChang Moo Kang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752 KoreaChang Ik Yoo...

The expression of TLR pathway molecules in peripheral blood mononuclear cells and their relationship with tumor invasion and cytokine secretion in laryngeal carcinoma.

Advances in Medical Sciences — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions: Our findings confirmed the implication of the TLRs pathway molecules in proinflammatory cytokine secretions and their importance as encouraging potential indicators for assessment of the degree of aggressive tumor phenotype. PMID: 22240197 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)

Assessing treatment effect in pancreatic cancer.

Archives of Pathology and Laboratory Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions.-Assessment of treatment effect in pancreatic cancer is difficult. Pathologists need to be aware that some histologic features of treatment effect overlap with histologic features seen in untreated pancreatic cancer, such as tumor cell anaplasia, necrosis, and fibrosis. Careful assessment of pancreatic resections, including detailed gross examination and thorough histologic sampling, is important in accurately assessing treatment effect and improving patient outcomes. PMID: 22208494 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

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The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Archives of Gynecology and Obstetrics — Fri, 30 Dec 2011 16:42:33 +0100

Conclusion After completion of this article, the reader should be aware of the symptoms of BOTs, the potential role and pitfalls of tumor marker measurement. In addition, the reader will understand the appearance of BOTs at imaging techniques; the reader will be able to compare and combine ultrasonography, MRI and positron emission tomography in diagnosing BOTs. In clinical practice, the reader should be better able to assess whether an ovarian mass is a benign tumor, a BOT or an invasive cancer. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-10DOI 10.1007/s00404-011-2194-1Authors Matteo Morotti, Department of Obstetrics and Gynecology, San Martino Hospital, University of Genoa, Largo R. Benzi 1, 16132 Genoa, ItalyMario Valenzano Menada, Departmen...

Immunohistochemical analysis of oral dysplasia: diagnostic assessment by fascin and podoplanin expression.

Acta Histochemica et Cytochemica — Wed, 28 Dec 2011 05:00:00 +0100

Authors: Shimamura Y, Abe T, Nakahira M, Yoda T, Murata S, Sugasawa M Abstract The aim of this study was to investigate fascin and podoplanin expression in oral dysplasia and carcinoma in situ (CIS) immunohistochemically, and to evaluate their relationship to histopathological diagnosis based on architectural and cytological features. Fascin and podoplanin expression patterns were analyzed immunohistologically in 26 specimens of oral lesions, including benign disease (hyperplasia, papilloma, and others), intraepithelial neoplasia/borderline disease (dysplasia), and malignant disease (CIS, invasive squamous cell carcinoma). Fascin expression was scored into four original categories, and podoplanin expression was scored into five previously established categories. The relationship be...

CT appearance of primary peritoneal serous borderline tumour: a rare epithelial tumour of the peritoneum.

The British Journal of Radiology — Mon, 26 Dec 2011 18:24:22 +0100

We report the CT findings of surgically proven PPSBT in which multiple peritoneal cysts were seen. Although rare, PPSBT should be considered in the differential diagnosis of primary peritoneal tumours. Since the prognosis of the disease is good, conservation of the uterus and ovaries should be a consideration in young female patients during surgery. PMID: 22190758 [PubMed - in process] (Source: The British Journal of Radiology)

Imaging of hepatocellular carcinoma.

Cancer Imaging — Mon, 26 Dec 2011 17:24:03 +0100

Authors: Lee JM Abstract Worldwide, hepatocellular carcinoma (HCC) is the fifth most common malignant neoplasm. The development of HCC in cirrhotic liver is described either as de novo hepatocarcinogenesis or as a multistep progression, from low-grade dysplastic nodule (DN) to high-grade DN, then to DN with microscopic foci of HCC, then to small HCC, and finally to overt carcinoma. Therefore, early detection and accurate assessment of small HCC is of great importance as the therapeutic efficacy of various treatments and the survival of patients with small HCC are much more successful than those for patients with larger tumors. The hallmark of HCC during computed tomography scan or magnetic resonance (MR) imaging is the presence of arterial enhancement followed by washout. The most ...

Analysis of the miR-34a locus in 62 patients with familial cutaneous melanoma negative for CDKN2A/CDK4 screening

Familial Cancer — Sat, 24 Dec 2011 16:45:48 +0100

Abstract MicroRNAs are small non-coding RNAs, which inhibit expression of specific target genes at the post-transcriptional level and are often misregulated in human cancer. Among them, miR-34a is considered a tumor suppressor with a hypothetical role in melanoma tumorigenesis. In this work, 62 Italian index patients with familial melanoma and negative for CDKN2A/CDK4 screening were investigated for miR-34a germline mutations. Eight novel miR-34a sequence variants were identified at both the heterozygous (c.+259G>A, c.+424G>A, c.+1465C>T, c.+1769C>T, c.+2456T>G, c.+2603C>T, c.+2972T>A, c.+3069T>C) and homozygous (c.+424G>A, c.+1465C>T, c.+1769C>T) states. Molecular screening identified all nucleotide changes in a healthy population of 150 con...

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Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors

Archives of Gynecology and Obstetrics — Sat, 24 Dec 2011 16:41:54 +0100

In conclusion, Brenner ovarian tumors are unilateral, small and benign neoplasms in their majority and present specific histopathological and immunopathological characteristics and mixed forms with other epithelial and germ cell neoplasms. This could be explained as a form of metaplasia or a diverse histogenesis from surface epithelium and/or the germ cell ovarian component. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2182-5Authors A. Kondi-Pafiti, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceEvi Kairi-Vassilatou, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceCh. Iavazzo, 2nd Clinic of Obstetrics and Gynecology, Aretaieion University Hospit...

Molecular pathology of pre-invasive breast disease in the screening setting: application in diagnosis and management

Diagnostic Histopathology — Thu, 22 Dec 2011 05:00:00 +0100

We present a review of the molecular pathology of common pre-invasive lesions of the breast particularly discussing diagnosis on needle core biopsy, their risk of progression, and clinical management following their mammographic detection. (Source: Diagnostic Histopathology)

Unexpected ovarian malignancy after conservative laparoscopic surgery: five case series in a half decade of experience

Archives of Gynecology and Obstetrics — Wed, 21 Dec 2011 20:07:58 +0100

Conclusion The main concern for laparoscopic management of ovarian masses is unexpected malignancy. However, with careful patient selection, proper technique and an experienced operator, laparoscopic treatment of ovarian masses is the best approach and should be implemented, with low risk of unexpected malignancy and recurrence. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2177-2Authors Noraziana Abd Wahab, Department of Obstetrics and Gynecology, Kulliyyah of medicine, Jalan Hospital, International Islamic University, 25710 Kuantan, Pahang, MalaysiaAmphan Chalermchockchareonkit, Department of Obstetrics and Gynecology, Thai-German Multidisciplinary Endoscopic Training Center, Faculty of Medicine Siriraj Hospital, Mahidol ...

Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer

Cancer Science — Mon, 19 Dec 2011 05:00:00 +0100

AbstractAngiogenesis plays a key role in the development and treatment response of various tumors. The signaling transductions mediated by the binding of VEGF to its receptor KDR is the most important pathway in tumor angiogenesis. Single nucleotide polymorphisms (SNPs) in VEGF have been extensively implicated in the etiology and treatment outcome of colorectal cancer (CRC). However, no study has been reported evaluating the role of KDR SNPs in CRC prognosis. We herein assessed the association between four potentially functional KDR SNPs and tumor recurrence in a Chinese population with 408 surgically resected CRC patients. The most significant SNP was for rs10013228 located in KDR gene promoter. Compared to the homozygous wild‐type genotype, the variant‐containing genotypes of this SN...

Cardiac surgery for carcinoid heart disease in 12 cases

General Thoracic and Cardiovascular Surgery — Thu, 15 Dec 2011 16:44:31 +0100

Conclusion Postoperative prognosis may be worse when preoperative left ventricular ejection fraction is borderline, even if it is within the normal limits. Cardiac evaluation is needed in all patients with carcinoid disease from the earliest time of medical and oncological therapy to improve patient outcome. Content Type Journal ArticleCategory Original ArticlePages 780-785DOI 10.1007/s11748-010-0758-9Authors Satsuki Komoda, Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyTakeshi Komoda, Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyMarianne E. Pavel, Department of Internal Medicine, Division of Hepatology, Gas...

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Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins

Journal of Clinical Pathology — Tue, 13 Dec 2011 05:00:00 +0100

Conclusion A predictive nomogram based on three histological criteria and surgical margin status can be used to calculate recurrence-free survival of an individual woman diagnosed with PT. This can be applied for patient counselling and clinical management. (Source: Journal of Clinical Pathology)

Overexpression of SGLT1 is correlated with tumor development and poor prognosis of ovarian carcinoma

Archives of Gynecology and Obstetrics — Fri, 09 Dec 2011 17:04:35 +0100

Conclusions SGLT1 overexpression, as examined by immunohistochemistry, is an independent biomarker for poor prognosis of patients with ovarian carcinoma. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1007/s00404-011-2166-5Authors Bingquan Lai, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan Road II, Guangzhou, 510080 ChinaYongbo Xiao, Department of Pathology, Cancer Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaHongwei Pu, Department of Pathology, Xinjiang Medical University, Urumuqi, 830054 ChinaQinghua Cao, Department of Pathology, Cancer Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaHualan Jing, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zh...

Good results for bowel cancer testing

NHS News Feed — Thu, 08 Dec 2011 17:30:00 +0100

Conclusion This analysis of a relatively new screening programme demonstrates that the programme has been effective in detecting bowel cancers at an early stage. This is extremely important in this disease, as in the absence of an effective screening programme most cases would not be diagnosed until they have progressed considerably. At this point treatment becomes more difficult, and survival is less likely than those cases diagnosed at an early stage. The researchers say that uptake of the programme outside of London was very good, and high by international standards. The study also revealed unexpected variations in participation across regions and socioeconomic levels. Knowledge of such variation is essential, as it allows programme administrators to alter their recruitment and invitat...

Weapons Ovarian Epithelial Tumors May Use in Immune Escape: An Immunohistochemical Correlational Study.

Pathology Oncology Research — Thu, 08 Dec 2011 05:00:00 +0100

Authors: Hasby EA Abstract Investigate FasL and survivin expression in a series of primary ovarian surface epithelial tumors, correlate their expression with each other, and characterize the presence of CD3+ T-lymphocytes in studied tumors and determine whether their presence correlates with FasL or survivin expression in malignant cases. FasL and survivin expression was assessed in 54 ovarian epithelial tumors. The results were compared between different tumor types and grades. Correlation between both markers' expression in all studied tumors was done. Either marker's expression was compared to the mean CD3+ T-lymphocytes per HPF in the studied malignant tumors. Either FasL or survivin expression was significantly higher in malignant versus benign ovarian epithelial tumors (p &...

Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors

Pediatric Surgery International — Wed, 07 Dec 2011 12:54:42 +0100

Conclusion The novel pediatric risk-of-malignancy index is able to accurately discriminate between benign and non-benign ovarian tumors in children and adolescents. Its preoperative application may guide surgical management decisions before the availability of histological confirmation. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00383-011-3031-0Authors Amos Hong Pheng Loh, Department of Paediatric Surgery, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore, 229899 SingaporeChiou Li Ong, Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, SingaporeShu Lin Lam, Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, S...

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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes

Journal of Cancer Research and Clinical Oncology — Tue, 06 Dec 2011 17:01:19 +0100

Conclusion These results suggest that common genetic variations in these pathways may modulate risk and clinical outcomes of endometrial cancer. Further replication and functional studies are needed to confirm these findings. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1103-0Authors Li-E Wang, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAHongxia Ma, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAKatherine S. Hale, Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USAMing Yin, Department of Epidemiology, U...

Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor

Pathology International — Thu, 01 Dec 2011 05:00:00 +0100

We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discord...

Significance of epidermal growth factor receptor expression in the grading of phyllodes tumors of the breast

Basic and Applied Pathology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions: Epidermal growth factor receptor overexpression, more than 10% of tumor cells, could be used as an ancillary tool for the discrimination of benign from borderline and malignant PTs. (Source: Basic and Applied Pathology)

Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival

Histopathology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions: Our findings suggest that Dock180 contributes to ovarian carcinogenesis and dissemination and is a potential prognostic marker and therapeutic target. (Source: Histopathology)

Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study

European Radiology — Tue, 22 Nov 2011 06:55:35 +0100

Conclusion Quantitative DCE-MRI is a feasible and accurate technique to differentiate malignant from benign adnexal tumours and could potentially help oncologists with management decisions. Key Points • Quantitative DCE MR imaging allows accurate differentiation between malignant and benign tumours • Quantitative DCE MRI may help predict peritoneal carcinomatosis associated with ovarian tumors • Quantitative DCE MRI helps distinguish between invasive and borderline primary ovarian tumours Content Type Journal ArticleCategory UrogenitalPages 1-8DOI 10.1007/s00330-011-2329-6Authors Isabelle Thomassin-Naggara, Department of Radiology, Hôpital Tenon, Assistance Publique–Hôpitaux de Paris, Paris, FranceDaniel Balvay, Labor...

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Clinical Significance of IEX-1 Expression in Ovarian Carcinoma.

Ultrastructural Pathology — Mon, 21 Nov 2011 20:36:21 +0100

Conclusion: With the development of epithelial ovarian tumors from benign to malignant, IEX-1 expression is decreased, concomitant with a decreased rate of cell apoptosis. Thus, IEX-1 is pro-apoptotic in the development of epithelial ovarian cancer. The pro-apoptotic activity may take part in restraining tumor growth at the early stage of ovarian epithelial cancer, whereas its decreased expression probably contributes to the abnormal survival advantage for malignant cancer. Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy. PMID: 22085302 [PubMed - in process] (Source: Ultrastructural Pathology)

Low‐grade serous carcinomas of the ovary contain very few point mutations

The Journal of Pathology — Mon, 21 Nov 2011 05:00:00 +0100

AbstractIt has been well established that ovarian low‐grade and high‐grade serous carcinomas are fundamentally different types of tumours. While the molecular genetic features of ovarian high‐grade serous carcinomas are now well known, the pathogenesis of low‐grade serous carcinomas, apart from the recognition of frequent somatic mutations involving KRAS and BRAF, is largely unknown. In order to comprehensively analyze somatic mutations in low‐grade serous carcinomas, we applied exome sequencing to the DNA of eight samples of affinity‐purified low‐grade serous carcinomas. A remarkably small number of mutations were identified in seven of these tumours: a total of 70 somatic mutations in 64 genes. The eighth case displayed mixed serous and endometrioid features and a mutator p...

Solid tumors in Turkish children: a multicenter study.

World Journal of Pediatrics : WJP — Mon, 21 Nov 2011 05:00:00 +0100

CONCLUSIONS: We conclude that the cancer patterns of children in the Ankara region mostly resemble with those of the western population. This study provides useful information on the diagnosis of solid tumors in children and highlights variations in cancer incidence in different age groups. PMID: 22105573 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)

Effectiveness of semi-quantitative multiphase dynamic contrast-enhanced MRI as a predictor of malignancy in complex adnexal masses: radiological and pathological correlation

European Radiology — Fri, 18 Nov 2011 06:55:03 +0100

Conclusion Threshold criteria using semi-quantitative multiphase DCE-MRI improves specificity in the prediction of malignancy in complex adnexal masses with enhancing components and is complementary to standard qualitative assessment. Key Points • Semi-quantitative DCE-MRI threshold criteria are effective for predicting ovarian malignancy • The surgical approach may be altered depending on DCE-MRI threshold criteria analysis • Borderline tumours demonstrate significant overlap with benign lesions using DCE-MRI threshold criteria Content Type Journal ArticleCategory Magnetic ResonancePages 1-11DOI 10.1007/s00330-011-2331-zAuthors Livia Bernardin, Policlinico GB Rossi, P.le L.A. Scuro, 37134 Verona, ItalyPhilip Dil...

Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution

Pediatric Surgery International — Wed, 16 Nov 2011 18:00:12 +0100

Conclusions The majority of pediatric ovarian tumors were benign disease, and the patients with malignant lesions had a good prognosis. In neonatal cases, an umbilical crease incision approach is feasible and provides excellent cosmesis. We recommend tumor resection with ovarian preservation through a minimally invasive approach (modified Rocky Davis incision) as the first line treatment for older pediatric patients with ovarian tumors other than those preoperatively diagnosed as malignant. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s00383-011-3004-3Authors Tatsuro Tajiri, Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanRyota Souzaki, Departmen...

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Laparoscopic versus open distal pancreatectomy: a systematic review of comparative studies

Surgical Endoscopy — Tue, 15 Nov 2011 06:46:48 +0100

Conclusions The laparoscopic approach to DP offers advantages over open surgery with lower operative morbidity, higher spleen preservation rate, and shorter hospital stay; these benefits are particularly observed in patients with benign disease and borderline malignancy. The experience with laparoscopic DP for malignant disease remains limited, and long-term follow-up data are required to clearly define this role. Content Type Journal ArticleCategory ReviewPages 1-10DOI 10.1007/s00464-011-2016-3Authors Asri C. Jusoh, Department of Hepato-Pancreato-Biliary Surgery, North Manchester General Hospital, Delaunays Road, Crumpsall, Manchester M8 5RB, UKBasil J. Ammori, Department of Hepato-Pancreato-Biliary Surgery, North Manchester General Hospital, Delaunays Road, Crump...

Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort

Human Reproduction — Thu, 10 Nov 2011 05:00:00 +0100

CONCLUSIONS Ovarian stimulation for IVF may increase the risk of ovarian malignancies, especially borderline ovarian tumours. More large cohort studies are needed to confirm these findings and to examine the effect of IVF treatment characteristics. (Source: Human Reproduction)

Laparoscopic management of large ovarian tumors: Clinical tips for overcoming common concerns

Journal of Obstetrics and Gynaecology Research — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion: Laparoscopic management of large ovarian tumors is feasible and efficient with appropriate patient selection and experience of surgeons. (Source: Journal of Obstetrics and Gynaecology Research)

Chromosome 17 centromere (CEP17) duplication as a predictor of anthracycline response: evidence from the NCIC Clinical Trials Group (NCIC CTG) MA.5 Trial

Breast Cancer Research and Treatment — Mon, 31 Oct 2011 16:52:57 +0100

This study suggests that CEP17 duplication has a borderline association with clinical responsiveness to anthracycline containing chemotherapy similar to previous results seen with HER2 amplification and TOP2A alteration in MA.5. An appropriately powered meta-analysis is required to discriminate the predictive value of these three candidate markers. Content Type Journal ArticleCategory Clinical trialPages 1-11DOI 10.1007/s10549-011-1840-4Authors Kathleen I. Pritchard, Sunnybrook Odette Cancer Centre, The University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, CanadaAlison Munro, Endocrine Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR UKFrances P. O’Malley, University of Toronto, Toronto, ON, CanadaDongshen...

Hormone therapy and ovarian borderline tumors: a national cohort study

Cancer Causes and Control — Fri, 28 Oct 2011 17:13:18 +0100

Conclusions Combined hormone therapy for more than 4 years increases the risk of ovarian borderline tumors. Content Type Journal ArticleCategory Original paperPages 1-8DOI 10.1007/s10552-011-9860-2Authors Lina Steinrud Mørch, Gynaecological Clinic, Copenhagen University Hospital, Copenhagen University, Section 3341, Blegdamsvej 9, 2100 Copenhagen, DenmarkEllen Løkkegaard, Gynaecological-obstetrical Department, Hillerød Hospital, Copenhagen University, Hillerød, DenmarkAnne Helms Andreasen, Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, DenmarkSusanne Krüger Kjær, Gynaecological Clinic, Copenhagen University Hospital, Copenhagen University, Section 3341, Blegdamsvej 9, 2100 Copenhagen, DenmarkØjvind Lidegaard, Gynaecolog...

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NHS Choices assessment of press reports about ovarian cancer risk from IVF

NeLM - News — Fri, 28 Oct 2011 04:00:00 +0100

Source: NHS Choices Area: News NHS Choices has assessed a report in the Daily Telegraph that in vitro fertilisation (IVF) doubles the risk of non-fatal ovarian cancer. The report is based on a large, long-term Dutch cohort study that examined the risk of ovarian cancer associated with IVF treatment. Its findings were published in 'Human Reproduction.' The study compared the risk of developing ovarian cancer in the 15 years following treatment with the risks of cancer in the general population and in women who had difficulty conceiving but did not undergo IVF treatment. The researchers found that the IVF group was over four-times as likely to have developed borderline ovarian tumours (not yet cancerous) compared to the non-IVF group. However, they were at no greater risk of deve...

IVF May Raise Risk for Less Aggressive Ovarian Cancer

WebMD Health — Thu, 27 Oct 2011 21:33:43 +0100

Women who undergo ovarian stimulation as part of IVF (in vitro fertilization) treatment may be more likely to develop "borderline" ovarian tumors, but not invasive ovarian tumors, later in life, Dutch researchers report. (Source: WebMD Health)

Ovarian cancer tied to fertility treatments: Cause for alarm?

Health News: CBSNews.com — Thu, 27 Oct 2011 19:31:53 +0100

Study found "unusually high" number of borderline ovarian tumors (Source: Health News: CBSNews.com)

Ovary cancer risk from IVF is small

NHS News Feed — Thu, 27 Oct 2011 18:05:00 +0100

Conclusion This was a large, long-term cohort study that examined the association between ovarian stimulation during fertility treatment and the subsequent risk of developing ovarian cancer. The study was well designed, especially in terms of its selection of an appropriate comparator group and its attempts to account for potential confounders. In their attempt to control potential confounders the researchers collected information on baseline ovarian cancer risk through a mailed questionnaire, and on treatment factors through medical record examination. However, data on factors such as family history of cancer, number of pregnancies, use of birth control and lifestyle characteristics were available in only 65.2% of the total cohort. This may bias the results, as there is no way of telling...

IVF May Be Tied To Ovarian Tumors Later In Life

Health News from Medical News Today — Thu, 27 Oct 2011 16:00:00 +0100

A Dutch study suggests that stimulating the ovaries to produce eggs for in vitro fertilization or IVF, may increase the risk of developing ovarian tumors, some of which may become cancerous, later in life. Overall, the researchers found rates of non-fatal "borderline ovarian tumors" were increased four-fold and rates of malignant tumors were increased two-fold compared to other women seeking fertility treatment who did not undergo IVF... (Source: Health News from Medical News Today)

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IVF May Raise Risk for Less Aggressive Ovarian Cancer

WebMD Health — Thu, 27 Oct 2011 05:00:00 +0100

Ovarian stimulation for IVF boosts risk of ovarian tumours

OnMedica Latest News — Thu, 27 Oct 2011 04:00:00 +0100

Risk highest for borderline ovarian tumours 15 + years after treatmentRelated items from OnMedicaContraceptive pill almost halves ovarian cancer riskVaginal radiotherapy better option for cancerConsultation opens on ovarian cancer guidanceOne or two doses of HPV jab may be enoughBenefit of Herceptin in more breast cancer cases (Source: OnMedica Latest News)

Fertility treatment raises tumor risk in study

Reuters: Health — Wed, 26 Oct 2011 23:14:53 +0100

LONDON (Reuters) - Women given drugs during fertility treatment to stimulate their ovaries to produce extra eggs have an increased risk of developing borderline ovarian tumors, Dutch researchers said on Thursday. (Source: Reuters: Health)

Fertility Treatment Raises Tumor Risk in Study

MedlinePlus Health News — Wed, 26 Oct 2011 22:14:53 +0100

Women given drugs during fertility treatment to stimulate their ovaries to produce extra eggs have an increased risk of developing borderline ovarian tumors, Dutch researchers said on Thursday.Source: Reuters Health Related MedlinePlus Pages: Female Infertility, Ovarian Cancer, Ovarian Disorders (Source: MedlinePlus Health News)

Ovarian stimulation for IVF treatment increases risk of borderline ovarian tumors later in life

EurekAlert! - Social and Behavioral Science — Wed, 26 Oct 2011 04:00:00 +0100

(European Society of Human Reproduction and Embryology) New research from The Netherlands has shown that sub-fertile women whose ovaries are stimulated into producing extra eggs for in-vitro fertilization have an increased risk of ovarian malignancies, in particular borderline ovarian tumors, later in life. (Source: EurekAlert! - Social and Behavioral Science)

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Survival outcomes in endometrial cancer patients are associated with CXCL12 and estrogen receptor expression

International Journal of Cancer — Tue, 25 Oct 2011 04:00:00 +0100

AbstractCXCL12 is a chemotactic cytokine that has pro‐metastatic functions in several malignancies through interactions with its receptor, CXCR4. CXCL12 is an estrogen‐regulated gene, and notably, estrogen is a major risk factor for endometrial cancer (EC) development. As few studies examine concurrent CXCL12, CXCR4, and estrogen receptor (ER) expression in EC patients, we examined this pathway in 199 EC patients with data from the University of Pittsburgh Medical Center Cancer Registry. Immunohistochemistry (IHC) was used to detect CXCR4, CXCL12, and ER protein expression. As CXCR4 expression was positive in all cases, this investigation focused on associations between CXCL12 and ER expression, clinicopathologic factors, and survival outcomes using chi‐square tests, Kaplan‐Meier g...

Leak-proof extracorporeal drainage for management of large ovarian tumors

Archives of Gynecology and Obstetrics — Fri, 21 Oct 2011 16:00:26 +0100

Conclusions Minilaparotomy with leak-proof extracorporeal drainage using cyanoacrylate adhesive and polyurethane membrane is reliable, safe, and feasible for management of large ovarian tumors with low probability of malignancy in selected patients. Content Type Journal ArticleCategory General GynecologyPages 1-4DOI 10.1007/s00404-011-2115-3Authors Shih-Shien Weng, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 TaiwanYeou-Lih Wang, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sect. 2, Chung-Shan North Road, Taipei, 10449 Taiwan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

A case of ovarian mucinous adenocarcinoma in a premenarcheal girl

International Journal of Clinical Oncology — Fri, 21 Oct 2011 05:55:13 +0100

We report a case of a 12-year-old premenarcheal girl who developed ovarian mucinous adenocarcinoma. The tumor, which originated from the right ovary, weighed 1400 g, and had a smooth surface and thin capsule, was extirpated. The cut surface showed multilocular cysts of various sizes and yellowish gelatinous to solid parts that accounted for approximately 40% of the cut surface. The histological findings showed a continuous mixture of mucinous adenoma, mucinous borderline tumor, and mucinous adenocarcinoma with an expansile invasive pattern. It was assumed that an ovarian mass developed in an early period after birth or infancy, and the mutation of certain oncogens occurred in an early period, leading to cancer. While some etiological hypotheses concerning ovarian carcinogenesis ...

Long‐term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer

Cancer — Fri, 21 Oct 2011 04:00:00 +0100

CONCLUSIONS:Gemcitabine‐based neoadjuvant chemotherapy confers a significant OS advantage by allowing the selection of patients who will derive greatest benefit from CRT. Median survival with this approach was similar to that seen with surgical resection. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Sporadic desmoid tumors of the chest: long-term follow-up of 28 multimodally treated patients [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 20 Oct 2011 04:00:00 +0100

Conclusions: Because the radicality of the first surgical resection is of essential importance for long-time local control of chest desmoids, accurate preoperative diagnostics and well-planned aggressive surgical resection of the primary tumor is recommended. Due to the low incidence of desmoids, multicentric randomized investigations would be mandatory to establish evidence-based protocol for desmoid tumors. (Source: European Journal of Cardio-Thoracic Surgery)

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Phyllodes Tumor of the Breast: Role of CD10 in Predicting Metastasis

Annals of Surgical Oncology — Tue, 18 Oct 2011 05:47:27 +0100

Conclusions The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodes tumors of the breast. Content Type Journal ArticleCategory Breast OncologyPages 1-4DOI 10.1245/s10434-011-2076-6Authors Mahmoud Al-Masri, Department of Surgical Oncology, King Hussein Cancer Center, Amman, JordanGhaleb Darwazeh, Department of Surgical Oncology, King Hussein Cancer Center, Amman, JordanSamer Sawalhi, Department of Surgical Oncology, King Hussein Cancer Center, Amman, JordanAyman Mughrabi, Department of Surgical Oncology, King Hussein Cancer Center, Amman, JordanMaher Sughayer, Department of Pathology, King Hussein Cancer Center, Amman, JordanMarwa Al-Shatti, Department of Pathology, King Hussein Cancer Center, Amman, Jordan Journal Annals of...

Malignant Transformation of a Serous Borderline Tumor and Early Metastasis of Associated Low-Grade Serous Carcinoma Detected on Screening Mammography [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Tue, 18 Oct 2011 04:00:00 +0100

(Source: Journal of Clinical Oncology)

Comparative Effectiveness of Digital Versus Film-Screen Mammography in Community Practice in the United States: A Cohort Study.

Annals of Internal Medicine — Tue, 18 Oct 2011 04:00:00 +0100

Conclusion: Overall, cancer detection with digital or film-screen mammography is similar in U.S. women aged 50 to 79 years undergoing screening mammography. Women aged 40 to 49 years are more likely to have extremely dense breasts and estrogen receptor-negative tumors; if they are offered mammography screening, they may choose to undergo digital mammography to optimize cancer detection. Primary Funding Source: National Cancer Institute. PMID: 22007043 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Adrenocortical tumors in children: imaging adenomas and carcinomas.

Radiologia — Mon, 17 Oct 2011 04:00:00 +0100

CONCLUSIONS: Adrenocortical tumors are rare in children. Adrenocortical tumors include adenomas and carcinomas, and in the absence of vascular infiltration and/or metastases it is difficult to differentiate between the two types by imaging and histology. The combination of an adrenal mass and clinical signs of adrenocortical hyperfunction in a child is virtually diagnostic of an adrenocortical tumor. PMID: 22014330 [PubMed - as supplied by publisher] (Source: Radiologia)

Node-negative T1–T2 anal cancer: Radiotherapy alone or concomitant chemoradiotherapy?

Radiotherapy and Oncology — Thu, 13 Oct 2011 04:00:00 +0100

Conclusions: In the management of node negative T1–T2 anal cancer, LRC and CSS tend to be superior in patients treated by combined CRT, even though the difference was not significant. Randomized studies are warranted to assess definitively the role of combined treatment in early-stage anal carcinoma. (Source: Radiotherapy and Oncology)

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Management of non metastatic phyllodes tumors of the breast: Review of the literature

Surgical Oncology — Thu, 13 Oct 2011 00:45:02 +0100

Abstract: Phyllodes tumors of the breast are rare tumors, accounting for less than 0.5% of all breast tumors. These tumors are comprised of both stromal and epithelial elements; and traditionally they are graded by the use of a set of histologic features into benign, borderline, and malignant subtypes. Unfortunately, the histologic classification of phyllodes tumors does not reliably predict clinical behavior.The mainstay of treatment of non metastatic phyllodes tumors of the breast is complete surgical resection with wide resection margins. Lumpectomy or partial mastectomy is the preferred surgical therapy. However, despite the complete surgical resection, local failure rate may be high; and 22% of malignant tumors may give rise to haematogenous metastases. The most frequent site of dista...

Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome

Human Reproduction Update — Wed, 12 Oct 2011 04:00:00 +0100

CONCLUSIONS Women with PCOS have increased serum concentrations of CVD risk markers compared with controls. Whether this apparent risk is translated into increased incidence of CVD in later life remains to be elucidated. (Source: Human Reproduction Update)

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

Cochrane Database of Systematic Reviews — Tue, 11 Oct 2011 01:20:04 +0100

CONCLUSIONS: EGFR inhibitors, including pertuzumab, may add activity to conventional chemotherapy for treatment of platinum-resistant ovarian cancer. Certain subsets of women with particularly aggressive tumours resistant to conventional chemotherapy may benefit from EGFR inhibitor treatment. Further RCTs are necessary before EGFR inhibitors are introduced as first- or second-line treatment of ovarian cancer. PMID: 21975775 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Node-negative T1-T2 anal cancer: Radiotherapy alone or concomitant chemoradiotherapy?

Mon, 10 Oct 2011 04:00:00 +0100

CONCLUSIONS: In the management of node negative T1-T2 anal cancer, LRC and CSS tend to be superior in patients treated by combined CRT, even though the difference was not significant. Randomized studies are warranted to assess definitively the role of combined treatment in early-stage anal carcinoma. PMID: 21993403 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Copy number aberrations in benign serous ovarian tumors: a case for reclassification?

Clinical Cancer Research — Wed, 05 Oct 2011 04:00:00 +0100

CONCLUSIONS: Chromosome 12 trisomy has been previously identified in pure fibromas, supporting the concept that a significant proportion of benign serous tumors are primary fibromas with an associated cystic mass. This is the first high resolution genomic analysis of benign serous ovarian tumors and demonstrates not only that the majority of benign serous tumors have no genetic evidence of epithelial neoplasia but that a significant proportion may be more accurately classified as primary fibromas. PMID: 21976534 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan

Archives of Oral Biology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusions: BQ-chewers who carry the G allele or G/G genotype in TNFA −308 may have an increased risk of OPSCC. The intensity of cigarette smoking modulates the effect of the combined TNFA genotypes on risk of BQ-related OPSCC. (Source: Archives of Oral Biology)

Peripheral T cell lymphomas with follicular T helper phenotype: a new basket or a distinct entity? Revising Karl Lennert’s personal archive

Histopathology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusions: This study shows that: (i) historical material can be still employed usefully, and (ii) the FTH‐phenotype corresponds to a broad spectrum of PTCLs that might form a new category to be validated in future molecular and clinicopathological analyses. (Source: Histopathology)

Comparison of stromal CD10 expression in benign, borderline, and malignant phyllodes tumors among Egyptian female patients.

Indian Journal of Pathology and Microbiology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusion: From these highly significant results, we believe that there is a strong correlation between CD10 expression and tumor grade, which could be an important observation that may have both diagnostic and prognostic implications as well as promising potential target for development of novel therapies. PMID: 22234101 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Uterine smooth muscle tumors of uncertain malignant potential and atypical leiomyoma: A morphological study of these grey zones with clinical correlation.

Indian Journal of Pathology and Microbiology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusions: 1) There is an overlap in using the terminologies as STUMP, AL, AL with low risk of recurrence, AL with low malignant potential. A designation of STUMP does convey a category of borderline malignancy to the gynecological surgeons. Most behave in a benign fashion and follow-up without adjuvant therapy is currently recommended. Critical evaluation of coagulative tumor necrosis is essential. Follow-up remains a challenge in our setting. PMID: 22234095 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Epithelial Ovarian Tumors in Adolescents: A Retrospective Pathologic Study and a Critical Review of the Literature

Journal of Pediatric and Adolescent Gynecology — Mon, 26 Sep 2011 04:00:00 +0100

Conclusions: A relatively high frequency of epithelial ovarian neoplasms among all ovarian tumors in a purely adolescent population was found in our study. Age-related selection bias may account at least in part for the discrepancy between our data and most previous reports. The most common subtype of epithelial ovarian tumor in our series was the benign serous cystadenoma. (Source: Journal of Pediatric and Adolescent Gynecology)

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MRI findings of prostate stromal tumour of uncertain malignant potential: a case report.

The British Journal of Radiology — Mon, 26 Sep 2011 00:39:37 +0100

Authors: Muglia VF, Saber G, Maggioni G, Monteiro AJ Abstract Prostatic stromal tumours are rare neoplasias that include benign, malignant and borderline lesions. Stromal tumour of uncertain malignant potential (STUMP) has been recently described and only a few reports exist in the literature. As a rare and distinct neoplasia, to date, there is no description of MRI findings of prostate STUMP. In this article, we describe the clinical and MRI features with histopathological correlation of a patient with prostate STUMP. PMID: 21933974 [PubMed - in process] (Source: The British Journal of Radiology)

Glowing dye 'boosts cancer surgery'

NHS News Feed — Mon, 19 Sep 2011 17:10:00 +0100

Conclusion This research has illustrated that fluorescent tagging of ovarian cancer cells during diagnostic keyhole surgery is not only possible, but it can also help surgeons identify small areas of cancerous tissue that they cannot see by regular visual inspection alone. This potentially allows surgeons to better identify cancerous tissue when assessing the stage of the cancer by laparoscopy, a technique which is often used alongside other diagnostic imaging procedures such as CT and MRI scanning. It may also help surgeons ensure that they remove all cancerous tissue during therapeutic surgery, which will usually be quite a major operation. In particular, the authors consider that it may guide surgeons when performing debulking surgery, and so improve the likely efficiency of the chemoth...

Disseminated tumor cells in pancreatic cancer – an independent prognosticator of disease progression and survival

International Journal of Cancer — Mon, 19 Sep 2011 04:00:00 +0100

AbstractPancreatic cancer is one of the most devastating cancers with a 6‐month median survival and a 5‐year survival rate of 3‐5%. Still important aspects of its aggressive biology remain elusive and advanced therapeutic regimens have not been substantially successful. We investigated the prognostic role of disseminated tumor cells (DTC) in bone marrow, a reservoir for early DTC potentially contributing to metastatic progression, of pancreatic cancer patients. After exclusion of patients with different post‐surgery diagnosis or missing DTC status (n=40) a total of 175 patients remained for final analyses. One‐hundred‐and‐nineteen patients were male and 96 female with a median age of 67 years, 96 patients underwent complete resection. Bone marrow aspirates taken at primary su...

Disseminated tumor cells in pancreatic cancer—an independent prognosticator of disease progression and survival

International Journal of Cancer — Mon, 19 Sep 2011 04:00:00 +0100

AbstractPancreatic cancer is one of the most devastating cancers with a 6‐month median survival and a 5‐year survival rate of 3–5%. Still important aspects of its aggressive biology remain elusive and advanced therapeutic regimens have not been substantially successful. We investigated the prognostic role of disseminated tumor cells (DTC) in bone marrow, a reservoir for early DTC potentially contributing to metastatic progression, of pancreatic cancer patients. After exclusion of patients with different postsurgery diagnosis or missing DTC status (n = 40) a total of 175 patients remained for final analyses. One‐hundred and nineteen patients were male and 96 female with a median age of 67 years, 96 patients underwent complete resection. Bone marrow aspirates taken at primary surgery...

The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population

Digestive and Liver Disease — Mon, 19 Sep 2011 04:00:00 +0100

Abstract: Background: Intraductal papillary neoplasms of the bile duct have been applied to certain types of papillary tumours occurring in the biliary tract. Although many cases have been sporadically reported, there remain controversies.Aims: To analyze the clinicopathologic characteristics and long-term survival of intraductal papillary neoplasms of the bile duct.Methods: The clinicopathologic data of 52 patients who underwent surgery for intraductal papillary neoplasms of the bile duct were retrospectively evaluated.Results: In our series, tumours located in intrahepatic and hilar bile duct, rather than in extrahepatic bile duct, were more commonly diagnosed as adenomas or borderline tumours (12/19 and 7/13 vs 6/20; P=0.046). And the gastric type was more commonly associated with adeno...

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Surgeons light up cancer cells to cut relapses

Guardian Unlimited Science — Sun, 18 Sep 2011 17:00:00 +0100

Doctors believe use of fluorescent dye could boost survival rates by guiding them to tiny clusters of malignant cellsA group of women with ovarian tumours have become the first in the world to have surgery using a procedure that makes cancer light up in the body.Operations were performed on 10 women as part of the first phase of a clinical trial to evaluate the technique, called fluorescence-guided surgery.Doctors developed the procedure to help surgeons remove malignant tissue from ovarian cancer patients and reduce the risk of the disease returning months and years later.The method illuminates cancer cells inside a patient's body to make it easier for surgeons to spot smaller cancers that can be easily missed, and to help them identify the borders between tumours and the healthy tissues ...

Accuracy of frozen section diagnosis of ovarian borderline tumor.

Gynecologic Oncology — Tue, 13 Sep 2011 04:00:00 +0100

CONCLUSION: Comprehensive surgical staging can be considered in BT >8cm in diameter, as well as those with micropapillary serous, endometrioid, and clear cell histology diagnosed at the time of frozen section analysis. PMID: 21920591 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Micropapillary pattern in serous borderline ovarian tumors: Does it matter?

Gynecologic Oncology — Mon, 12 Sep 2011 04:00:00 +0100

CONCLUSIONS: Because micropapillary SBOT was significantly associated with peritoneal implants, especially invasive implants, and lymph node involvement, complete staging procedures, including lymph node dissection, are recommended. However, micropapillary SBOT itself was not significantly associated with DFS. Peritoneal implant was the only factor independently associated with tumor recurrence. PMID: 21917305 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Intra-operative frozen section analysis for suspected early-stage ovarian cancer: 11 years of Gateshead Cancer Centre experience.

BJOG : An International Journal of Obstetrics and Gynaecology — Tue, 06 Sep 2011 04:00:00 +0100

Conclusions Intra-operative FS analysis has excellent diagnostic test accuracy and assists gynaecological oncologists to perform the appropriate surgery in 95% of cases, thereby preventing the morbidity of surgical staging in benign cases and the morbidity of restaging procedures or chemotherapy in early-stage malignant tumours. PMID: 21895958 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Intra‐operative frozen section analysis for suspected early‐stage ovarian cancer: 11 years of Gateshead Cancer Centre experience

BJOG: An International Journal of Obstetrics and Gynaecology — Mon, 05 Sep 2011 23:00:00 +0100

Conclusions Intra‐operative FS analysis has excellent diagnostic test accuracy and assists gynaecological oncologists to perform the appropriate surgery in 95% of cases, thereby preventing the morbidity of surgical staging in benign cases and the morbidity of restaging procedures or chemotherapy in early‐stage malignant tumours. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

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Postoperative respiratory depression with pregabalin: A case series and a preoperative decision algorithm.

Pain Research and Management — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Eipe N, Penning J Abstract Pregabalin is gaining popularity in the perioperative period for its usefulness in treating neuropathic pain and its apparent opioid- sparing effect. The present report describes the perioperative course of three patients who received pregabalin and experienced significant respiratory depression in the postoperative period. All three patients consented to the report and publication of the present case series. The first patient was elderly with borderline renal dysfunction. She experienced respiratory arrest in the immediate postoperative period following a craniotomy for tumour excision. The second patient presented with severe respiratory depression 12 h after receiving a spinal anesthetic for joint replacement, and was later found to have clini...

Aggressive multifocal form of epithelioid hemangioendothelioma--case report.

Collegium Antropologicum — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Duletić-Nacinović A, Grohovac D, Dobrila-Dintinjana R, Brncić N, Jonjić N Abstract Epithelioid hemangioendothelioma (EHE) is a rare tumor of the vascular origin. It was first described in its pulmonary form by Dail and Leibow in 1975 and named "intravascular bronchioalveolar tumor" (IVBAT). Since then, reports of occurrences of the tumor have been made for number of locations, but most often tumor can be found in soft tissues, liver, lungs, bone and skin. It is considered to be a low or borderline malignant tumor with, usually, slow progression, but aggressive forms have been described. We here report a case of a 46-year old female patient with multifocal malignant tumor spreading to lungs, liver, spleen and with synchronous involvement of lumbal vertebrae, illiac bone...

Behavior of Serous Borderline Ovarian Tumors With and Without Micropapillary Patterns: Results of a French Multicenter Study

Annals of Surgical Oncology — Wed, 31 Aug 2011 05:51:32 +0100

Conclusions Patients with MP-SBOT represent a heterogeneous population in terms of presence of invasive peritoneal implants. Conservative surgery could be a suitable option for MP-SBOT patients without implants and who wish to conserve childbearing potential, without increasing the risk of recurrence. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1245/s10434-011-2039-yAuthors R. Fauvet, Department of Gynecology and Obstetrics, University Hospital of Amiens, University of Picardie, Jules Verne, Amiens, FranceE. Demblocque, Department of Gynecology and Obstetrics, University Hospital of Amiens, University of Picardie, Jules Verne, Amiens, FranceP. Morice, Department of Gynecologic Surgery, Gustave Roussy Cancer Institute, University of Paris...

Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials

Surgery — Mon, 29 Aug 2011 22:07:55 +0100

Conclusion: Neoadjuvant treatment seems to have some activity in patients with borderline/unresectable pancreatic adenocarcinoma. Nearly one third of tumors initially deemed marginal for operative intervention were able to be ultimately resected after treatment. Until more effective targeted chemotherapeutics are developed, the only group of patients with pancreatic cancer that may benefit from neoadjuvant treatment are those with locally advanced disease. (Source: Surgery)

Ovarian cancer during pregnancy

International Journal of Gynaecology and Obstetrics — Mon, 29 Aug 2011 04:00:00 +0100

Conclusion: Early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. Tumor staging is possible during pregnancy, but the appropriateness of surgery needs to be considered carefully. Ideally, the treatment strategy should be discussed and structured on an individual basis. (Source: International Journal of Gynaecology and Obstetrics)

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Primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient. Case report and review of the literature.

BioMed Central — Fri, 26 Aug 2011 23:00:00 +0100

Conclusion: This is the third case of primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient reported in the literature. The preoperative diagnosis is impossible. Laparotomy constitutes the only diagnostic and curative approach. (Source: BioMed Central)

Fine needle aspiration cytology in ovarian lesions: an institutional experience of 584 cases

Cytopathology — Wed, 24 Aug 2011 23:00:00 +0100

Conclusion: FNAC has a high specificity for diagnosis of ovarian/adnexal lesions but greater experience is required for the accurate subtyping of neoplasms and sensitivity is limited by inconclusive/inadequate results. (Source: Cytopathology)

Optimal primary surgical treatment for advanced epithelial ovarian cancer.

Cochrane Database of Systematic Reviews — Sat, 20 Aug 2011 17:00:05 +0100

CONCLUSIONS: During primary surgery for advanced stage epithelial ovarian cancer all attempts should be made to achieve complete cytoreduction. When this is not achievable, the surgical goal should be optimal (< 1 cm) residual disease. Due to the high risk of bias in the current evidence, randomised controlled trials should be performed to determine whether it is the surgical intervention or patient-related and disease-related factors that are associated with the improved survival in these groups of women. The findings of this review that women with residual disease < 1 cm still do better than women with residual disease > 1 cm should prompt the surgical community to retain this category and consider re-defining it as 'near optimal' cytoreduction, reserving the term 'suboptimal' c...

Phyllodes Tumors: Race-Related Differences

Journal of the American College of Surgeons — Thu, 18 Aug 2011 04:00:00 +0100

Background: Phyllodes tumors (PT) are rare breast malignancies accounting for 0.5% to 1% of all breast tumors. PT have unpredictable behavior, with recurrence rates as high as 40%. A dearth of information exists about racial differences; elucidation of these differences is the objective of this study.Study Design: A retrospective review of patients treated for PT at either Moffitt Cancer Center or University of Texas Health Science Center San Antonio from 1999 to 2010.Results: Of the 124 patients, 71 (57%) were treated at Moffitt Cancer Center and 53 (42%) at University of Texas Health Science Center San Antonio. Mean age at diagnosis was 44 years (15 to 70 years). Thirty-three patients required mastectomy. Combining both cohorts, 42% of the patients were Caucasian, 43% were Hispanic, and ...

Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension

Medical Oncology — Mon, 08 Aug 2011 19:55:34 +0100

Abstract Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination. In every patient, at least 1 but no more than 4 biopsies were taken from places visualized as pathologic, surrounding primary tumor, and at least 1 biopsy from places that appeared visually normal. Sensitivity, specificity, positive, and negative...

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Outcomes after resection of locally advanced or borderline resectable pancreatic cancer after neoadjuvant therapy

American Journal of Surgery — Mon, 08 Aug 2011 04:00:00 +0100

Conclusions: Postoperative mortality and morbidity do not significantly increase after neoadjuvant treatment. Neoadjuvant treatment in locally advanced pancreatic cancer can lead to an objective pathologic response, but this does not significantly improve survival after resection. (Source: American Journal of Surgery)

[External validation of simple ultrasound rules of Timmerman on 122 ovarian tumors.]

Gynecologie, Obstetrique et Fertilite — Wed, 03 Aug 2011 23:00:00 +0100

CONCLUSION: Most adnexal masses can be classified according to the ultrasound simple rules of the score of Timmerman with a good specificity to eliminate their malignant or borderline characteristics. Tumors which cannot be classified according to these rules must be referred to an expert ultrasonographist. PMID: 21820936 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

Med Sci Monit 2011; 17(8):BR228-234 "RCAS1 expression in mobile tongue squamous cell carcinoma: An immunohistochemical study"

Medical Science Monitor — Mon, 01 Aug 2011 05:00:00 +0100

Conclusions: Our data support evidence for possible implication of RCAS1 at the early stage of tumor progression in mobile tongue SCC, whereas the survival prediction using RCAS1 expression as a clinical marker seems uncertain for this type of malignancy. (Source: Medical Science Monitor)

External validation of the adapted Risk of Malignancy Index incorporating tumor size in the preoperative evaluation of adnexal masses

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 01 Aug 2011 04:00:00 +0100

Conclusion: Both RMI-3 and RMI-4 were able to discriminate between non-invasive lesions and invasive malignant adnexal masses, with similar performances. Including tumor size in the RMI does not improve its performance. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Evaluation of Intratumoral HER-2 Heterogeneity by Fluorescence In Situ Hybridization in Invasive Breast Cancer: A Single Institution Study.

J Korean Med Sci — Sun, 31 Jul 2011 23:00:00 +0100

In conclusion, HER-2 gene heterogeneity of invasive breast cancer is identified in routine FISH examination. This may affect the results of HER-2 gene amplification status in FISH studies. PMID: 21860549 [PubMed - in process] (Source: J Korean Med Sci)

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Protein Expressions and Genetic Variations of SLC5A8 in Prostate Cancer Risk and Aggressiveness

Urology — Fri, 29 Jul 2011 04:00:00 +0100

Conclusion: These data suggest that the expression pattern of SLC5A8 might be used as a diagnostic biomarker, and a larger study is required to assess the importance of SLC5A8 single nucleotide polymorphisms in prostate cancer. (Source: Urology)

Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors

Interdisciplinary Perspectives on Infectious Diseases — Thu, 28 Jul 2011 13:57:28 +0100

Conclusion. Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development. (Source: Interdisciplinary Perspectives on Infectious Diseases)

Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression [Gastrointestinal Cancer]

Journal of Clinical Oncology — Wed, 27 Jul 2011 23:00:00 +0100

Conclusion This regimen appears effective and has acceptable toxicity. The primary end point (1-year overall survival rate > 45%) was met, with encouraging survival duration. Smad4(Dpc4) immunostaining correlated with the pattern of disease progression. Prospective validation of Smad4(Dpc4) expression in cytology specimens as a predictive biomarker is warranted and may lead to personalized treatment strategies for patients with localized pancreatic cancer. (Source: Journal of Clinical Oncology)

Metastatic urachal carcinoma of the ovary

Journal of Obstetrics and Gynaecology Research — Tue, 26 Jul 2011 23:00:00 +0100

AbstractA 52‐year‐old woman had undergone a partial cystectomy for a cystic mass at the dome of the urinary bladder in 1997. The pathological diagnosis was a urachal mucinous cystadenoma with borderline malignancy. Twelve years later, multiple masses were noted on the uterus, ovaries and abdominal wall. She underwent debulking surgery, including a total hysterectomy, bilateral salpingo‐oophorectomy, pelvic lymph node dissection, infracolic omentectomy, appendectomy, colon mass removal and abdominal wall mass removal. Remnants of the tumor were seeded throughout the abdominal cavity. The pathological evaluation confirmed metastatic urachal mucinous adenocarcinoma in both ovaries, the abdominal wall, the colon mass, the uterosacral ligament and the bladder. Adjuvant chemotherapy with p...

Photon and proton therapy planning comparison for malignant glioma based on CT, FDG-PET, DTI-MRI and fiber tracking.

Acta Oncologica — Tue, 26 Jul 2011 16:02:53 +0100

Conclusion. The IMPT technique produced the most conform plans. For tumors located in the one of the cerebral hemispheres, the non-coplanar RA and the IMPT techniques were able to reduce doses to the contralateral hippocampus. The IMPT technique offered the largest sparing of the brain and fiber tracts. RA techniques tended to produce more conform target doses than IMRT. PMID: 21767174 [PubMed - in process] (Source: Acta Oncologica)

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Frozen section diagnoses of 578 ovarian tumors made by pathologists with and without expertise on gynecologic pathology.

Gynecologic Oncology — Fri, 15 Jul 2011 23:00:00 +0100

CONCLUSION: Intraoperative frozen section diagnosis has a high accuracy rate for ovarian pathologies. Those rates do increase even more if it is evaluated by the Gyn pathologists. PMID: 21767870 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Oncologic and reproductive outcomes of cystectomy compared with oophorectomy as a treatment for borderline ovarian tumours

Human Reproduction — Thu, 14 Jul 2011 23:00:00 +0100

CONCLUSIONS A USO is an appropriate treatment for women with BOTs who wish to preserve fertility. However, a cystectomy is a satisfactory fertility-sparing therapy when a cystectomy is the only surgical option. (Source: Human Reproduction)

Epithelial Ovarian Carcinoma Types and the Coexistence of Ovarian Tumor Conditions

Advances in Urology — Thu, 14 Jul 2011 17:39:48 +0100

Conclusion. One in six patients with a malignant ovarian tumor has a coexisting epithelial tumor condition in the ovary, which is also rather frequently observed in the diagnostic work-up practice. (Source: Advances in Urology)

Epiregulin as a marker for the initial steps of ovarian cancer development.

International Journal of Oncology — Wed, 13 Jul 2011 23:00:00 +0100

Authors: Amsterdam A, Shezen E, Raanan C, Slilat Y, Ben-Arie A, Prus D, Schreiber L Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner. However, there were no systematic follow-up studies of Ep expression in the development of different stages of ovarian cancer. Using specific antibodies to Ep and the indirect immunocytochemistry methods, we found that in normal ovary the staining for Ep was mainly confined to the epithelial cells, while the stromal cells were only occasionally and moderately stained. In contrast in benign serous and mucinous tumors most of the tumor cells showed a clear staining in the cytoplasm. In borderline serous and mucinous tumors the staining was mu...

Prospective randomized controlled study comparing cell block method and conventional smear method for pancreatic juice cytology

Digestive Endoscopy — Tue, 12 Jul 2011 23:00:00 +0100

Conclusions: The CB method using immunostaining for pancreatic juice cytology showed a much lower rate of equivocal borderline malignancy and a tendency for a higher diagnostic yield compared with smear cytology. Its diagnostic sensitivity, however, was not satisfactory except for pancreatic‐head cancer. (Source: Digestive Endoscopy)

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Neuroendocrine Tumor (Carcinoid) of the Appendix With Mucocele: Sonographic and Pathological Findings

Journal of Diagnostic Medical Sonography — Mon, 11 Jul 2011 23:00:00 +0100

Acute right lower quadrant pain is a common emergency department presentation. Medical imaging has a main role to rule out appendicitis. Distinguishing between appendicitis and the other two major appendix pathologies, mucocele and carcinoid tumors, is not easy, but it is important for medical and surgical management planning. Appendix mobility is not usually assessed during sonography, but is it helpful? When comparing sonography and computerized tomography with histopathology findings to distinguish appendiceal pathologies, appendix mobility was found to be a key component. Appendix diameter, wall thickness, hyperemia, and surrounding echogenic fat are signs of an inflammatory process that will fix the appendix. Appendiceal carcinoids and mucoceles, on the other hand, will not initially ...

Paratubal Borderline Tumor Diagnosed In The Adolescent Period: A Case Report And Review of The Literature

Journal of Pediatric and Adolescent Gynecology — Thu, 07 Jul 2011 23:00:00 +0100

Conclusion: The evaluation of the structure of cyst by ultrasound and the performance of intraoperative frozen section analysis are two important issues to diagnose the nature of a cyst. Fertility-sparing surgery is the main point of management. (Source: Journal of Pediatric and Adolescent Gynecology)

The Serum CA-125 Concentration Data Assists in Evaluating CT Imaging Information When Used to Differentiate Borderline Ovarian Tumor from Malignant Epithelial Ovarian Tumors.

Korean J Radiol — Thu, 30 Jun 2011 23:00:00 +0100

CONCLUSION: The serum CA-125 concentration is of additional diagnostic value when used in conjunction with the CT imaging results for differentiating BOTs from MEOTs. PMID: 21852906 [PubMed - in process] (Source: Korean J Radiol)

Preoperative Diagnosis of Ductal Carcinoma In Situ Arising Within a Mammary Fibroadenoma: A Case Report

Japanese Journal of Clinical Oncology — Wed, 29 Jun 2011 23:00:00 +0100

We present this case to increase awareness of this entity and stress the need for histological evaluation of some breast masses. (Source: Japanese Journal of Clinical Oncology)

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Archives of Gynecology and Obstetrics — Wed, 29 Jun 2011 10:52:48 +0100

Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. Content Type Journal ArticlePages 1-5DOI 10.1007/s00404-011-1957-zAuthors A. Kondi-Pafiti, Pathology Laboratory, University of Athens, Athens, GreeceE. Papakonstantinou, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Iavazzo, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Grigoriadis, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofi...

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Stage IA Ovarian Cancers: Comparison of Sonographic Findings and Histopathologic Types Between Patients With Normal and Elevated Serum Cancer Antigen 125 Levels

Journal of Ultrasound in Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions— Stage IA ovarian cancers with normal CA-125 levels tend to be smaller, have less solid components, and have a slightly different distribution of histopathologic types than cancers with elevated CA-125 levels. (Source: Journal of Ultrasound in Medicine)

Fertility sparing surgery for ovarian tumors in children and young adults

Archives of Gynecology and Obstetrics — Thu, 23 Jun 2011 16:28:01 +0100

Conclusion Fertility sparing surgery for malignant ovarian tumors in children and young adults has excellent prognosis and should be attempted whenever possible. Content Type Journal ArticlePages 1-3DOI 10.1007/s00404-011-1946-2Authors El-Said Abdel-Hady, Department of Obstetrics and Gynecology, Mansoura University, Mansoura, EgyptReda Abdel-Hady Hemida, Department of Obstetrics and Gynecology, Mansoura University, Mansoura, EgyptAnas Gamal, Department of Obstetrics and Gynecology, Mansoura University, Mansoura, EgyptMaged El-Shamey, Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Stability of HER2-positive status in breast carcinoma: a comparison between primary and paired metastatic tumors with regard to the possible impact of intervening trastuzumab treatment

Annals of Oncology — Wed, 22 Jun 2011 23:00:00 +0100

Conclusions: HER2-positive status remained unchanged in most paired metastases. Loss of HER2-positive status did not seem to be affected by trastuzumab treatment. Differences in testing and interpretation may account for the discordance in some cases. (Source: Annals of Oncology)

The proliferation markers Ki-67/MIB-1, phosphohistone H3, and survivin may contribute in the identification of aggressive ovarian carcinomas.

International Journal of Clinical and Experimental Pathology — Sun, 19 Jun 2011 23:00:00 +0100

In conclusion, the proliferation markers Ki-67/MIB-1, PHH3, and survivin are positively correlated with each other and with tumor grade, and may contribute in the identification of aggressive ovarian carcinomas. PMID: 21738816 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

T-staging of rectal cancer: accuracy of 3.0 Tesla MRI compared with 1.5 Tesla

Abdominal Imaging — Wed, 15 Jun 2011 06:21:24 +0100

Conclusions This is the first study to compare 3T with 1.5T MRI for T-staging of rectal cancer within the same patients. Our results showed no difference between 3T and 1.5T-MRI for the distinction between T1-2 and borderline T3 tumors, regardless of expertise. The higher resolution at 3T-MRI did not aid in the distinction between desmoplasia in T1-2-tumors and tumor stranding in T3-tumors. Larger studies are needed to acknowledge these findings. Content Type Journal ArticlePages 1-7DOI 10.1007/s00261-011-9770-5Authors Monique Maas, Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The NetherlandsDoenja M. J. Lambregts, Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht,...

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Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors.

Acta Histochemica — Tue, 14 Jun 2011 23:00:00 +0100

Authors: Serra KP, Sarian LO, Rodrigues-Peres RM, Vassallo J, Soares FA, Pinto GA, da Cunha IW, Shinzato JY, Derchain SF The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the inva...

Robot-Assisted Spleen-Preserving Laparoscopic Distal Pancreatectomy

Annals of Surgical Oncology — Sun, 12 Jun 2011 06:04:34 +0100

Conclusions The unique characteristics of a robotic surgical system were thought to be very helpful during the spleen-preserving laparoscopic distal pancreatectomy.2 – 6 However, cost is one of the main obstacles for the procedure’s popular clinical practice.2 Content Type Journal ArticlePages 1-1DOI 10.1245/s10434-011-1816-yAuthors Sung Hoon Choi, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaChang Moo Kang, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaWoo Jung Lee, Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaHoon Sang Chi, Division of Hepatobiliary and P...

Borderline papillary serous tumor of the fimbriated end of the fallopian tube with peritoneal implants

Journal of Obstetrics and Gynaecology Research — Wed, 08 Jun 2011 23:00:00 +0100

AbstractDiagnosis of Borderline papillary serous tumor of the fallopian tube was comprehensively established by Zheng in 1996 supported mostly by a histological similarity to its ovarian counterpart. It is a very rare entity with eight cases published so far and the ninth case described here as a 41‐year‐old woman presented with non‐specific lower abdominal pain, dyspareunia and dysuria. Left adnexal mass was identified and she was operated on. It turned out the tumor was attached exclusively to the left tube, with no connection to any of the surrounding structures and with histology of borderline serous tumor with non‐invasive implants in the left and right ovary and visceral peritoneum. Reviewing available data on genetics of these tumors there was diploid status in one examined ...

Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor

Journal of Assisted Reproduction and Genetics — Wed, 08 Jun 2011 15:46:48 +0100

Conclusion(s) Mature oocytes were successfully retrieved ex-vivo from the hyperstimulated ovary recovered via laparoscopy. The procedure can be performed in a quick manner, with standard equipment, without damaging the ovary, the follicles or the oocytes, and without the risk of cancer cell spillage associated with the standard transvaginal oocyte retrieval if there is concern of ovarian surface/peritoneal metastatic disease. Content Type Journal ArticlePages 1-2DOI 10.1007/s10815-011-9596-7Authors Silvina Bocca, The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 605 Colley Ave., Norfolk, VA, USADaynelle Dedmond, Sentara Surgery Specialists, Williamsburg, VA, USAEstella Jones, The Jones Institute ...

Preoperative evaluation of the longitudinal extent of borderline resectable hilar cholangiocarcinoma by intraductal ultrasonography

Journal of Gastroenterology and Hepatology — Mon, 06 Jun 2011 23:00:00 +0100

Conclusions: HC staging based on IDUS findings was highly accurate. We therefore highly recommend using IDUS for optimal surgical planning in patients with borderline resectable HC. (Source: Journal of Gastroenterology and Hepatology)

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Alpha-methylacyl-CoA racemase (AMACR) expression in epithelial ovarian cancer

Virchows Archiv — Sat, 04 Jun 2011 06:07:09 +0100

Abstract Alpha-methylacyl-CoA racemase (AMACR) is involved in the cellular metabolism of fatty acids. It is a prognostic factor in prostate and colorectal cancer. So far, little is known about its expression and prognostic role in ovarian cancer. We investigated the expression of AMACR in a total of 420 ovarian tumors (388 carcinomas, 32 borderline tumors) by immunohistochemistry on tissue microarrays of two independent patient cohorts. In both cohorts, cytoplasmic AMACR expression was identified in 11.8% (16/136) and 5.4% (13/239), respectively, of the ovarian carcinomas. In contrast, borderline tumors did not show any AMACR expression. AMACR expression was significantly associated with histological subtype, FIGO stage, and grade in one cohort and low estrogen receptor le...

A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases.

Wed, 01 Jun 2011 23:00:00 +0100

CONCLUSIONS: This pooled analysis has provided robust outcome data regarding the use of arc-based radiotherapy with SIB. PMID: 21641067 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Use of laser-assisted photodynamic therapy for leukoplakia in the larynx

Operative Techniques in Otolaryngology - Head and Neck Surgery — Wed, 01 Jun 2011 04:00:00 +0100

Photodynamic therapy is a method for achieving selective tissue destruction of neoplastic and atypical proliferative cells using a chemical photosensitizer, which accumulates within the tumor, and a light source to activate a free radical cascade. This method has been used for a variety of malignant and premalignant conditions. We have been using photodynamic therapy in the larynx for intractable and difficult keratosis with atypia using a nebulized formulation of aminolevulinic acid activated with the 585-nm pulse dye laser (Cynosure, Chelmsford, MA). We can perform this procedure in the office under local anesthesia using a flexible nasopharyngoscope with a 2.5-mm working channel. We have found it to be a valuable adjunct for patients with widespread keratosis and dysplasia. In this arti...

Lancet seminar: Pancreatic cancer

NeLM - News — Thu, 26 May 2011 23:00:00 +0100

Source: Lancet Area: News The authors of this article discuss the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma, under the following headings: . Epidemiology . Pathophysiology . Screening to detect curable precursor lesions . Clinical presentation . Diagnosis and staging . Principles of management . Surgery . Pathological findings after surgery . Adjuvant and neoadjuvant treatment . Management of borderline resectable disease . Management of advanced disease . Measurement of tumour response . Investigational treatments for advanced pancreatic cancer . Supportive care (Source: NeLM - News)

Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer.

Clinical Cancer Research — Wed, 25 May 2011 23:00:00 +0100

CONCLUSION: Based on findings indicated in a primary investigation set and confirmed in the large secondary validation set, we report for the first time plasma GDF-15 as a biomarker for endometrial cancer phenotype, including presence of lymph node metastasis and reduced survival. Its applicability as predictor of metastatic nodes and in monitoring treatment of endometrial cancer needs to be further studied. PMID: 21616994 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Characterization of Papillary Projections in Benign Versus Borderline and Malignant Ovarian Masses on Conventional and Color Doppler Ultrasound

American Journal of Roentgenology — Sun, 22 May 2011 23:00:00 +0100

CONCLUSION. Association of morphologic and vascular ultrasound findings can highly suggest the diagnosis of benign or malignant papillary projection. (Source: American Journal of Roentgenology)

Breast carcinomas with borderline (2+) HER2 immunohistochemistry: percentage of cells with complete membrane staining for HER2 and the frequency of HER2 amplification

Journal of Clinical Pathology — Thu, 19 May 2011 23:00:00 +0100

Conclusions This audit suggests that increasing the threshold for 2+ from 10% to 20% complete membrane staining would reduce the number of in-situ hybridisation tests by 36%, but reduce the detection of amplified tumours by 14%. (Source: Journal of Clinical Pathology)

Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women

American Journal of Obstetrics and Gynecology — Mon, 16 May 2011 04:00:00 +0100

Conclusion: HE4 offers superior specificity compared to CA-125 for the differentiation of benign and malignant adnexal masses in premenopausal women. (Source: American Journal of Obstetrics and Gynecology)

Laparoendoscopic single-site surgery (LESS) for adnexal tumors: one surgeon's initial experience over a one-year period

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 16 May 2011 04:00:00 +0100

Conclusions: Our results suggest that LESS is a safe and feasible alternative to conventional laparoscopic surgery for the treatment of adnexal tumors. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification

Breast Cancer Research and Treatment — Sat, 14 May 2011 16:02:40 +0100

Abstract Breast phyllodes tumors are rare neoplasms which present challenges for histological classification. Microscopic features are not always predictive of clinical behavior, and scarce data exist on the prognostic role of biological markers. Our study evaluated a series of 145 phyllodes tumors diagnosed at the Department of Pathology, Singapore General Hospital between 2006 and 2009, incorporating 91 (62.8%) benign, 40 (27.6%) borderline, and 14 (9.7%) malignant phyllodes tumors. Antibodies to keratin 15 (KRT15), transcobalamin I (TCN1), and homeobox gene Hox-B13 (HOXB13) were applied to sections cut from tissue microarray blocks. KRT15 and TCN1 positivity was defined when there was reactivity of 1% or more stromal cells, while HOXB13 positivity was defined using a H-...

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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

Blood — Wed, 11 May 2011 23:00:00 +0100

The World Health Organization classification of lymphoid neoplasms updated in 2008 represents a worldwide consensus on the diagnosis of these tumors and is based on the recognition of distinct diseases, using a multidisciplinary approach. The updated classification refined the definitions of well-recognized diseases, identified new entities and variants, and incorporated emerging concepts in the understanding of lymphoid neoplasms. However, some questions were unresolved, such as the extent to which specific genetic or molecular alterations define certain tumors, and the status of provisional entities, categories for which the World Health Organization working groups felt there was insufficient evidence to recognize as distinct diseases at this time. In addition, since its publication, new...

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]

Radiographics recent issues — Wed, 11 May 2011 23:00:00 +0100

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelomic spread of disease beyond the ovaries, whereas low-grade serous and mucinous carcinomas commonly manifest w...

Blue Nevi and Related Tumors

Clinics in Laboratory Medicine — Fri, 06 May 2011 06:58:39 +0100

This article succinctly describes the common dermal dendritic proliferations and updates readers on newly classified entities and variants. The differential diagnosis of the main entities and strategies to distinguish them from their melanocytic and nonmelanocytic mimics is also presented. (Source: Clinics in Laboratory Medicine)

Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules

Annals of Nuclear Medicine — Mon, 02 May 2011 14:59:49 +0100

Conclusions The result of this study indicates that FDG PET/CT can provide additional information for the differentiation between benign and malignant IPMNs of the pancreas with mural nodules. Content Type Journal ArticlePages 1-10DOI 10.1007/s12149-011-0494-yAuthors Kentaro Takanami, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanTomomichi Hiraide, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanMasashi Tsuda, Department of Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi 980-8574, JapanYasuhiro Nakamura, Department of Pathology, Tohoku University Graduate Sc...

Animal‐type melanoma – tumor cell invasion of dermal lymphatics and molecular identification of lymph node metastasis

JDDG — Sat, 30 Apr 2011 23:00:00 +0100

SummaryAnimal‐type melanoma (ATM) represents a rare subtype within the wide spectrum of melanocytic tumors. Clinically, ATM lesions appear as sharply demarcated, brown, black and dark blue pigmented nodules, which show grey‐white surface elements on dermatoscopy. The tumor is restricted to the dermis and arranged in irregular fascicles, which are composed of spindle‐shaped and epithelioid melanocytes. Moderate tumor cell pleomorphism, mitoses and apoptotic cells all suggest a malignant process. Abundant, finely dispersed melanin pigment within tumor cells as well as numerous melanophages are strongly suggestive of ATM. Even though locoregional lymph node metastases are frequently found at diagnosis, the course of ATM is generally benign. Specific molecular changes may be detected in ...

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[An ovarian mucinous borderline tumour with mixed mural nodules.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Wed, 27 Apr 2011 23:00:00 +0100

We report an additional case of mixed type mural nodules of anaplastic carcinoma and sarcoma-like developed in an ovarian mucinous borderline tumour at a 60-year-old woman.We give details about the classification, the differential diagnosis and prognosis of theses nodules. PMID: 21531088 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

New guidance for ovarian cancer tests

NHS News Feed — Wed, 27 Apr 2011 11:05:00 +0100

The diagnosis and early treatment of ovarian cancer is in the news today, with the publication of new NICE guidance for doctors on recognising ovarian cancer. NICE calls for more initial investigations (such as a blood test) to take place in GP surgeries - this is so that more women are referred to hospital specialists and begin treatment sooner, greatly increasing their chances of survival. The guidance focusses on areas where there is current uncertainty or wide variation in clinical practice among doctors with regard to the detection of ovarian cancer, particularly in primary care where most women will present. In particular, the guidance gives clear advice on when to carry out a specific blood test when cancer is suspected. Dr Fergus Macbeth, Director of the Centre for Clinical Practic...

The Influence of Prognostic Factors and Adjuvant Chemoradiation on Survival After Pancreaticoduodenectomy for Ampullary Carcinoma

Journal of Gastrointestinal Surgery — Wed, 27 Apr 2011 05:47:36 +0100

Conclusions Advanced primary tumor stage and age were associated with inferior OS after PD for AC. Adjuvant therapy did not impact survival. Patients with advanced tumor stage should be considered for clinical trials of adjuvant therapy after PD with novel compounds and optimized radiation therapy strategies. Content Type Journal ArticlePages 1-6DOI 10.1007/s11605-011-1518-6Authors Timothy N. Showalter, Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USATingting Zhan, Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USAP. Rani Anne, Department of Radiation Oncology, Jefferson Medical College of Thomas ...

NeoGemTax: Gemcitabine and Docetaxel as Neoadjuvant Treatment for Locally Advanced Nonmetastasized Pancreatic Cancer

World Journal of Surgery — Wed, 27 Apr 2011 05:43:28 +0100

Conclusions NeoGemTax was safe and resection was feasible in a number of patients after systemic neoadjuvant treatment. Further randomized clinical trials are needed to identify novel multimodal regimens that would be able to increase the percentage of patients undergoing curative pancreatic cancer surgery despite advanced tumor stage at the time of diagnosis. Content Type Journal ArticlePages 1-10DOI 10.1007/s00268-011-1113-8Authors Klaus Sahora, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaIrene Kuehrer, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaMartin Schindl, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Aus...

Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy

Advances in Pharmacological Sciences — Tue, 26 Apr 2011 14:23:42 +0100

Conclusions. Despite the small number of samples used in this study, the results indicate that metabolomic analysis of intact tissues by HRMAS-NMR is a promising technique which might be applicable to the therapeutic management of patients. (Source: Advances in Pharmacological Sciences)

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Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial

Breast Cancer Research and Treatment — Mon, 25 Apr 2011 16:41:41 +0100

Abstract Overexpression of topoisomerase II protein (topo 2α) is postulated to be more closely associated with responsiveness to anthracycline-containing chemotherapy than human epidermal growth factor receptor type 2 (HER2) gene amplification or alterations in the topoisomerase II alpha gene (TOP2A). The authors used tissue microarrays from 477 of 710 premenopausal women with node-positive breast cancer randomized to CEF or CMF adjuvant chemotherapy in the NCIC Clinical Trials Group Mammary 5 (MA.5) trial. No significant interaction was found between treatment and continuous topo 2α level in either relapse-free (RFS) or overall survival (OS). In 136 patients (28.5%) whose tumors showed topo 2α overexpression by immunohistochemistry based on a cut-off of 13%, CEF was sup...

The first experience of robot assisted spleen-preserving laparoscopic distal pancreatectomy in Korea.

Yonsei Medical Journal — Thu, 21 Apr 2011 22:00:30 +0100

Authors: Kim DH, Kang CM, Lee WJ, Chi HS Spleen-preservation has recently been emphasized in benign and borderline malignant pancreatic diseases requiring distal pancreatectomy. Reports to suggest that laparoscopic distal pancreatectomy is feasible and safe have been increasingly published. Robotic surgical system has been introduced and is expected to provide unique advantages in laparoscopic surgery. However, robot-assisted pancreatic surgery has not yet been performed by many surgeons. A 45-year-old female patient with abdominal discomfort was found to have pancreatic cyst in the body of the pancreas. Mucinous cystic tumor of the pancreas was the most favourable preoperative diagnosis. She underwent spleen-preserving laparoscopic distal pancreatectomy by using da Vinci surgical robo...

Role of Minimally Invasive Surgery in Staging of Ovarian Cancer

Current Treatment Options in Oncology — Tue, 19 Apr 2011 07:13:29 +0100

Opinion statement Since the introduction of laparoscopy and robotic surgery in gynecologic practice in the last several decades, use of these minimally invasive surgical techniques has increased dramatically. The role of minimally invasive surgical techniques continues to expand because they offer reduced intraoperative and postoperative complications, less intraoperative blood loss, and a shorter postoperative recovery. Despite initial concerns about the use of minimally invasive surgery in gynecologic oncology, this approach has been shown to be safe and effective in the management of uterine and cervical cancer, and minimally invasive surgical management of these malignancies is now commonplace. Concerns remain regarding the use of minimally invasive surgery for the sta...

Activation of sonic hedgehog signaling in oral squamous cell carcinomas: a preliminary study

Human Pathology — Fri, 15 Apr 2011 04:00:00 +0100

Summary: Sonic hedgehog signaling is important for human development, and aberrant regulation of this pathway can result in the development of tumors. The aim of this study was to examine the expression of sonic hedgehog signaling molecules in oral squamous cell carcinoma. By quantitative real-time polymerase chain reaction, the expression of SHH, SMO, PTCH-1, and GLI-1 was analyzed in 30 oral squamous cell carcinoma cases and 8 samples of nonneoplastic oral mucosa and associated to clinical pathologic features. The expression of β-catenin, cyclin D1, Wnt-1, and Egfr was evaluated by immunohistochemistry in 26 available cases of oral squamous cell carcinoma. Normal oral mucosa from healthy individuals was negative for all genes that were evaluated. SHH, PTCH-1, SMO, and GLI-1 were not exp...

Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study.

Croatian Medical Journal — Thu, 14 Apr 2011 23:00:00 +0100

Conclusion. Expression of C/T antigens may represent a marker of potential prognostic relevance in MBC. PMID: 21495200 [PubMed - in process] (Source: Croatian Medical Journal)

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Accuracy of frozen section diagnosis of borderline ovarian tumors.

Gynecologic Oncology — Mon, 11 Apr 2011 23:00:00 +0100

CONCLUSIONS: Frozen section analysis of BOTs has low accuracy, sensitivity, and positive predictive value, and underdiagnosis and overdiagnosis are frequent. Therefore, surgical decision-making for BOTs based on frozen section diagnosis should be done carefully, especially in tumors with mucinous histology. PMID: 21492922 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells

Oncogene — Sun, 10 Apr 2011 23:00:00 +0100

Authors: J-C Cheng, N Auersperg & P C K Leung (Source: Oncogene)

CD34, CD117, and Ki-67 Expression in Phyllodes Tumor of the Breast: An Immunohistochemical Study of 33 Cases

International Journal of Surgical Pathology — Wed, 06 Apr 2011 23:00:00 +0100

This study indicates that CD34 and CD117 are differentially expressed in benign and malignant PTs. These markers, therefore, in combination, may be used as an adjunct to morphology in the subclassification of PTs. (Source: International Journal of Surgical Pathology)

Mammoplasty for symmetry in breast reconstruction and histologic assessment.

Canadian Journal of Surgery — Thu, 31 Mar 2011 23:00:00 +0100

Conclusion: Systematic histologic analysis of glandular mammary tissue sampled after reduction mammoplasty in the particular context of breast reconstruction after breast cancer makes it possible to discover lesions that were not seen in presurgical evaluation. The early management of these borderline occult lesions could reduce the incidence of breast cancer in these at-risk patients. PMID: 21443831 [PubMed - as supplied by publisher] (Source: Canadian Journal of Surgery)