MedWorm: Brain Cancers

Minority, Underprivileged Patients Not as Likely to be Referred to Specialty Hospitals for Brain Tumors-3/15/10

Johns Hopkins Medicine News — Fri, 19 Mar 2010 16:30:10 +0100

African-American, Hispanic, and economically disadvantaged patients with brain tumors are significantly less likely to be referred to high-volume hospitals that specialize in neurosurgery than other patients of similar age, the same gender, and with similar comorbidities, according to new research by Johns Hopkins doctors. The finding, published in the March Archives of Surgery, suggests a scenario in direct contrast to recommendations from federal health care agencies encouraging better access and quality of health care for people of all races. (Source: Johns Hopkins Medicine News)

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ORI Finds Misconduct in Work on Brain Tumor Treatment; Papers on Glycosylation Technique Withdrawn; Falsified Images and Data Manipulation, But Conclusions Stand; Protein Structures May Have Been Fabricated

Biotechnology Law Report — Fri, 19 Mar 2010 00:21:08 +0100

Biotechnology Law Report Dec 2009, Vol. 28, No. 6: 735-736. (Source: Biotechnology Law Report)

Effect of Brain Tumor Size and Location on Seizure Risk Varies With Tumor Grade

Medscape Today Headlines — Thu, 18 Mar 2010 19:28:45 +0100

Dr. Laura Barclay discusses an imaging study comparing the size and location of brain tumors presenting with seizures vs those presenting with nonseizure symptoms. Medscape Neurology & Neurosurgery (Source: Medscape Today Headlines)

High chromosomal instability in brain metastases of colorectal carcinoma

Cancer Genetics and Cytogenetics — Thu, 18 Mar 2010 16:03:06 +0100

Abstract: Information on structural chromosomal changes in brain metastases (BM) of colorectal carcinoma (CRC) is very limited. Therapeutic and diagnostic strategies to reduce the risk of BM have potential impact on cancer mortality. By using comparative genomic hybridization, the primary CRC of 11 patients and their corresponding 13 BM were analyzed. BM showed significantly more mean chromosomal aberrations than the primary CRC (13.6±2.1 vs. 7.9±1.9, P=0.03), significantly more chromosomal gains (7.2±0.9 vs. 3.5±0.9, P=0.01), and tended to have also more losses (6.1±1.4 vs. 4.0±1.1, P=0.29). Changes that occurred significantly more often in BM than in primary CRC were gains of 8q, 12p, 12q, and 20p, as well as losses of 5q. BM of CRC show a significantly higher chromosomal instabili...

The A61G EGF polymorphism is associated with development of extraaxial nervous system tumors but not with overall survival

Cancer Genetics and Cytogenetics — Thu, 18 Mar 2010 16:03:03 +0100

Abstract: Epidermal growth factor can activate several signaling pathways, leading to proliferation, differentiation, and tumorigenesis of epithelial tissues by binding with its receptor. The EGF protein is involved in nervous system development, and polymorphisms in the EGF gene on chromosome band 4q25 are associated with brain cancers. The purpose of this study was to investigate the association between the single-nucleotide polymorphism of EGF+61G/A and extraaxial brain tumors in a population of the southeast of Brazil. We analyzed the genotype distribution of this polymorphism in 90 patients and 100 healthy subjects, using the polymerase chain reaction–restriction fragment length polymorphism technique. Comparison of genotype distribution revealed a significant difference between pat...

Blocking Cancer In Its Path: New Cellular Defect Discovered

Health News from Medical News Today — Thu, 18 Mar 2010 07:00:00 +0100

UCSF researchers have discovered that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility. The scientists also found that a new generation of inhibitory drugs offers promise in correcting this defect. According to the study team, this discovery has broad clinical implications in the fight against cancer and could affect treatment of lymphoma and many other forms of the disease, including prostate cancer, breast cancer, colorectal cancer, brain cancer and multiple myeloma... (Source: Health News from Medical News Today)

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Study Documents Increasing Racial Disparities In Access To High Quality Care For Brain Tumors

Health News from Medical News Today — Thu, 18 Mar 2010 07:00:00 +0100

African Americans and Hispanic patients appear less likely than white patients to have access to high-quality surgical care for brain tumors, according to a report in the March issue of Archives of Surgery, one of the JAMA/Archives journals. The article is one of several in the issue focusing on cancer, and is being published in conjunction with a JAMA theme issue on cancer... (Source: Health News from Medical News Today)

Study Documents Increasing Racial Disparities In Access To High Quality Care For Brain Tumors

Cancer / Oncology News From Medical News Today — Thu, 18 Mar 2010 07:00:00 +0100

Robertson Foundation donates $10.2 million for Duke Cell Therapy Center

EurekAlert! - Medicine and Health — Thu, 18 Mar 2010 04:00:00 +0100

(Duke University Medical Center) A $10.2 million commitment from the Robertson Foundation to create a state-of-the-art Translational Cell Therapy Center will advance Duke Medicine's pioneering cell therapy research and treatment programs for children and adults with cancer, cerebral palsy, stroke and brain injuries suffered at birth. (Source: EurekAlert! - Medicine and Health)

Development of a Predictor for Human Brain Tumors Based on Gene Expression Values Obtained from Two Types of Microarray Technologies

OMICS: A Journal of Integrative Biology — Thu, 18 Mar 2010 01:15:39 +0100

OMICS: A Journal of Integrative Biology , Vol. 0, No. 0. (Source: OMICS: A Journal of Integrative Biology)

Lycopene in treatment of high-grade gliomas: A pilot study.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 17 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Lycopene in treatment of high-grade gliomas: A pilot study.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 17 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

A Brain Surgeon Takes A Skeptical Look At Medical Technology

Health News from Medical News Today — Wed, 17 Mar 2010 09:00:00 +0100

We are enamored with technology, especially when it comes to health care. But newer does not necessarily mean better. Technology continues to drive up the cost of health care, often without sufficient proof it is superior to existing medical devices and equipment. Consider what happened with laser surgery in the late '80s and early '90s. Neurosurgeons enthusiastically embraced systems that vaporized brain tumors. Lasers were promoted as more precise than the old ways of cutting, suctioning or cauterizing tumors... (Source: Health News from Medical News Today)

Underpriveleged patients not as likely to be referred to specialty hospitals for brain tumors

ScienceDaily Headlines — Wed, 17 Mar 2010 06:00:00 +0100

African-American, Hispanic and economically disadvantaged patients with brain tumors are significantly less likely to be referred to high-volume hospitals that specialize in neurosurgery than other patients of similar age, the same gender, and with similar comorbidities, according to new research. (Source: ScienceDaily Headlines)

Top five cancer controversies explained by experts at Cancer Research UK

Daily Express - Health — Wed, 17 Mar 2010 00:00:00 +0100

TALKING too long on your phone gives you brain tumours, deodorants give you breast cancer, reusing plastic water bottles releases cancer-causing chemicals. We've all heard the rumours, but should we take them seriously? (Source: Daily Express - Health)

2010 Ivy Request for Proposals

ScanGrants feed — Wed, 17 Mar 2010 00:00:00 +0100

The Ben and Catherine Ivy Foundation is a non-profit organization that funds Patient-Focused Research on gliomas leading to the development of better diagnostics and treatment that offer long-term survival and a high quality of life for patients with brain tumors. Since our inception in 2007, the Foundation has funded $20.2M in glioma research. Guided by its strategic plan and mission, the Ivy Foundation is interested in funding projects on the leading edge whose primary objective is to accomplish one or more of the following in a 12-month project period starting no later than July 2010: Enhance the output of a clinical trial for adults with GBM by performing correlative studies which significantly increase understanding of the biologic impact of a candidate therapeutic and/or interpretat...

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NABTC Applauds CMS Action to Improve Access to Clinical Trials

NABTC — Tue, 16 Mar 2010 22:40:01 +0100

The North American Brain Tumor Coalition joined others in the patient advocacy community in commending action by the Centers for Medicare & Medicaid Services (CMS) to remove barriers to Medicare beneficiaries’ participation in clinical trials. Although there has been a policy for Medicare payment of routine patient care costs incurred in clinical trials since 2000, the policy does not include adequate protections for Medicare beneficiaries enrolled in Medicare Advantage (MA) plans. MA enrollees who participate in trials out of their MA plan have been required to pay out-of-network cost-sharing for the routine patient care costs of trials. Most of these patients, who do not have supplemental insurance, have found those costs unaffordably high and have declined to participa...

Congress Poised to Take Final Vote on Health Care Reform; NABTC Urges Action

NABTC — Tue, 16 Mar 2010 22:28:30 +0100

Final House and Senate votes on the health care reform legislation are expected the week of March 15, although some reports have suggested a delay in the vote timing. The House will consider the Senate-passed bill, and then both Houses are scheduled to consider amendments to the underlying Senate bill. While Democratic leaders and President Obama are pressing for the “yes” votes necessary for passage, there is much press coverage of the procedures that may be used to secure passage of the reform bill. The North American Brain Tumor Coalition has not commented on those procedural matters, but it has once again joined with colleagues in the patient advocacy community to articulate the elements of health reform that are critical for cancer patients and others with serious and ...

Register Now! Brain Tumor Action Week in DC on May 3 and 4

NABTC — Tue, 16 Mar 2010 22:09:01 +0100

Please join the North American Brain Tumor Coalition and its friends for Brain Tumor Action Week in Washington, D.C. On Monday, May 3, the Coalition invites you to an education day, featuring a program focusing on brain tumor research and care and including training for advocacy visits to Congress. On Tuesday, May 4, advocates will meet with their Representatives and Senators to discuss policy issues of importance to the brain tumor community. We’ll be pressing Congress to fund the National Institutes of Health generously, continue a Peer-Reviewed Cancer Research Program at the Department of Defense that supports pediatric brain tumor research, and ensure a strong and coordinated brain tumor research program at the National Cancer Institute and National Institute of Neurological...

Minority, Underpriveleged Patients Not as Likely to be Referred to Specialty Hospitals for Brain Tumors-3/15/10

Johns Hopkins Medicine News — Tue, 16 Mar 2010 16:57:53 +0100

New Brain Tumor Videos Added to Virtualtrials.com

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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New Brain Tumor Videos Added to Virtualtrials.com

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

New Brain Tumor Videos Added to Virtualtrials.com

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Quality of Brain Cancer Treatment Varies by Race (CME/CE)

MedPage Today Public Health — Tue, 16 Mar 2010 13:13:15 +0100

African Americans and Hispanic patients are increasingly less likely than whites to receive high-quality brain cancer treatment, a study has found. (Source: MedPage Today Public Health)

University of Rochester Medical Center hosts Brain Tumor Awareness Week events

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

University of Rochester Medical Center hosts Brain Tumor Awareness Week events

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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University of Rochester Medical Center hosts Brain Tumor Awareness Week events

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Minority, Underprivileged Patients Not As Likely To Be Referred To Specialty Hospitals For Brain Tumors

Health News from Medical News Today — Tue, 16 Mar 2010 09:00:00 +0100

Minority, Underprivileged Patients Not As Likely To Be Referred To Specialty Hospitals For Brain Tumors

Cancer / Oncology News From Medical News Today — Tue, 16 Mar 2010 09:00:00 +0100

IBTA E-News March 2010

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 08:58:48 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

IBTA E-News March 2010

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 08:58:48 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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IBTA E-News March 2010

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Mar 2010 08:58:48 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

With Medicaid Cuts, Doctors and Patients Drop Out

RWJF News Digest - Quality/Equality — Tue, 16 Mar 2010 04:00:00 +0100

Carol Y. Vliet’s cancer returned with a fury last summer, the tumors metastasizing to her brain, liver, kidneys and throat. (Source: RWJF News Digest - Quality/Equality)

Risk factors for fatigue severity in primary brain tumor patients

Cancer — Tue, 16 Mar 2010 00:00:00 +0100

In addition to neurologic symptoms, fatigue is commonly reported in patients with primary brain tumors during radiation therapy and in long-term survivors of low-grade brain tumors. Other factors have not been explored. The aim of this study was to identify demographic and clinical factors that predict fatigue severity and to evaluate the association of fatigue with other symptoms throughout the disease trajectory.Two hundred one patients with primary brain tumors completed the M. D. Anderson Symptom Inventory-Brain Tumor Module and a demographic checklist. Clinical data, including treatment, tumor grade, and performance status, were also collected. Correlations among fatigue and other recorded symptoms were evaluated. Logistic regression modeling was performed to evaluate factors associat...

Cyr61 Mediates Hepatocyte Growth Factor-Dependent Tumor Cell Growth, Migration, and Akt Activation.

Cell Research — Tue, 16 Mar 2010 00:00:00 +0100

In this study, we investigate if Cyr61 is a downstream effector of HGF/c-Met pathway activation in human glioma cells. A semiquantitative immunohistochemical analysis of 112 human glioma and normal brain specimens showed that levels of tumor-associated Cyr61 protein correlate with tumor grade (P < 0.001) and with c-Met protein expression (r(2) = 0.4791, P < 0.0001). Purified HGF rapidly upregulated Cyr61 mRNA (peak at 30 minutes) and protein expression (peak at 2 hours) in HGF(-)/c-Met(+) human glioma cell lines via a transcription- and translation-dependent mechanism. Conversely, HGF/c-Met pathway inhibitors reduced Cyr61 expression in HGF(+)/c-Met(+) human glioma cell lines in vitro and in HGF(+)/c-Met(+) glioma xenografts. Targeting Cyr61 expression with small interfering RNA (siR...

Disparities in Access to Neuro-oncologic Care in the United States [Original Article]

Archives of Surgery — Mon, 15 Mar 2010 19:50:50 +0100

Conclusions African Americans and Hispanics have disproportionately worse access to high-quality neuro-oncologic care over time compared with whites. Higher countywide median household income and decreased countywide poverty rate were associated with better access to high-volume hospitals, implicating socioeconomic factors in predicting admission to high-quality centers. (Source: Archives of Surgery)

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What Do We Gain and Lose From Database Studies?: Comment on "Disparities in Access to Neuro-oncologic Care in the United States" [Invited Critique]

Archives of Surgery — Mon, 15 Mar 2010 19:50:50 +0100

(Source: Archives of Surgery)

Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2

Breast Cancer Research and Treatment — Mon, 15 Mar 2010 17:58:15 +0100

In conclusion, HER-2 over-expressing breast cancer cells resistant to trastuzumab can be targeted for selective gene expression and destruction by viruses with envelope-proteins engineered to bind to this antibody. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0828-9Authors Kai-xin Zhang, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaConnie Kim, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaElaine Chow, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaIrvin S. Y. Chen, University of California, Los Angeles David Geffen School of Medicine Los Angeles CA USAWilliam Jia, University of British Columbia Department of Surgery and Brain Research Centre Vancouver BC CanadaPaul S. R...

Imaging and Clinical Features of an Intra-Axial Brain Stem Schwannoma [BRAIN]

American Journal of Neuroradiology — Mon, 15 Mar 2010 15:24:08 +0100

SUMMARY: A 68-year-old man presented with a highly symptomatic brain stem tumor originally thought to be a brain stem glioma. Intraoperative MR imaging guidance was used to resect the tumor, and real-time evoked potentials improved during surgery. Pathology findings unexpectedly indicated that the tumor was an intra-axial brain stem schwannoma, a condition reported, to our knowledge, only 6 times previously in the literature. The patient made an excellent recovery with reversal of his symptoms. (Source: American Journal of Neuroradiology)

Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging--Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme [BRAIN]

American Journal of Neuroradiology — Mon, 15 Mar 2010 15:24:07 +0100

CONCLUSIONS: This study failed to demonstrate a correlation between ADC and ve. This is important because it suggests that though the mechanisms underlying these parameters are theoretically similar, they actually reflect different aspects of tumor microenvironment. Consequently ADC and ve should be considered to provide independent information about the properties of the EES. (Source: American Journal of Neuroradiology)

Assessment of Vascular Supply of Hypervascular Extra-Axial Brain Tumors with 3T MR Regional Perfusion Imaging [BRAIN]

American Journal of Neuroradiology — Mon, 15 Mar 2010 15:24:07 +0100

CONCLUSIONS: RPI with selective labeling of the external carotid artery is feasible and may provide information about the vascular supply of hypervascular extra-axial brain tumors. (Source: American Journal of Neuroradiology)

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Stem Cells, Radial Glial Cells, and a Unified Origin of Brain Tumors [PERSPECTIVES]

American Journal of Neuroradiology — Mon, 15 Mar 2010 15:24:06 +0100

(Source: American Journal of Neuroradiology)

Talking With Your Children About Brain Tumors -- A Seminar in Long Branch, NJ

Clinical Trials And Noteworthy Treatments For Brain Tumors — Mon, 15 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Talking With Your Children About Brain Tumors -- A Seminar in Long Branch, NJ

Clinical Trials And Noteworthy Treatments For Brain Tumors — Mon, 15 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Talking With Your Children About Brain Tumors -- A Seminar in Long Branch, NJ

Clinical Trials And Noteworthy Treatments For Brain Tumors — Mon, 15 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Talking With Your Children About Brain Tumors -- A Seminar in Long Branch, NJ

Clinical Trials And Noteworthy Treatments For Brain Tumors — Mon, 15 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Study documents increasing racial disparities in access to high quality care for brain tumors

EurekAlert! - Cancer — Mon, 15 Mar 2010 04:00:00 +0100

(JAMA and Archives Journals) African Americans and Hispanic patients appear less likely than white patients to have access to high-quality surgical care for brain tumors, according to a report in the March issue of Archives of Surgery, one of the JAMA/Archives journals. (Source: EurekAlert! - Cancer)

Small cell carcinoma of the brain without extracranial involvement by serial CT, MRI and PET.

International Journal of Clinical and Experimental Pathology — Sun, 14 Mar 2010 20:24:03 +0100

Authors: Terada T The author reports herein a case of small cell carcinoma of the brain without extracranial tumors by serial imaging modalities. A 75-year-old man presented with headache. Brain CT and MRI revealed a solitary cystic tumor (5 x 6 x 7 cm) in the left occipital lobe. Blood laboratory test revealed no significant findings. Preoperative diagnosis was a primary or metastatic brain tumor. Preoperative systemic examinations including CT, MRI and PET revealed no extracranial tumors. Tumorectomy was performed. Pathologically, the tumor was small cell carcinoma positive for four types of pancytokeratins, cytokeratin (CK) 7, CK 18, thyroid transcriptional factor-1 (TTF-1), CD56, chromogranin, synaptophysin, neuron-specific enolase, p53 protein, KIT, PDGFRA, and Ki-67 antigen (labe...

Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sun, 14 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sun, 14 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sun, 14 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sun, 14 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sun, 14 Mar 2010 14:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings

Journal of Cancer Research and Clinical Oncology — Sun, 14 Mar 2010 11:26:26 +0100

This study analyzed the genetic alterations associated with this pathological heterogeneity in order to identify the genetic processes involved in transformation from a benign to an aggressive malignant tumor. Methods A histological and molecular analysis of a single MPNST tumor that was subdivided into three histopathologically distinct regions, a benign PNF (region 1), an atypical PNF (region 2), and a high-grade MPNST (region 3), was carried out. Tumor DNA from each region was analyzed in conjunction with the patient’s lymphocyte DNA. Somatic mutation analyses included loss-of heterozygosity (LOH), MLPA analysis, NF1 gene sequencing, and a microarray comparative genomic hybridisation (array CGH) analysis. Results The patient had a germline ...

Dealing with death keeps doctor going

OrlandoSentinel: Medical Research — Sun, 14 Mar 2010 00:00:00 +0100

As Dr. Richard W. Byrne labored for more than three hours to remove a malignant tumor from his patient's brain, he knew his efforts would not defeat the deadly cancer. The goal was to buy time. Time for the 44-year-old patient to spend with his wife... (Source: OrlandoSentinel: Medical Research)

Dealing with death keeps doctor going

OrlandoSentinel: Medical Research — Sun, 14 Mar 2010 00:00:00 +0100

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[Whole-body MRI and FDG-PET/CT imaging diagnostics in oncology.]

Der Radiologe — Sun, 14 Mar 2010 00:00:00 +0100

Authors: Schmidt GP, Haug A, Reiser MF, Rist C The advent of whole-body MRI (WB-MRI) has introduced a systemic approach to oncologic imaging compared to established sequential, multi-modal diagnostic algorithms. Hardware innovations, such as whole-body scanners at 1.5 Tesla and also recently 3 Tesla, combined with acquisition acceleration techniques, have made WB-MRI clinically feasible. With this method dedicated assessment of individual organs with various soft tissue contrast, high spatial resolution and contrast media dynamics can be combined with whole-body anatomic coverage.PET/CT has established itself as a powerful modality in the staging of patients suffering from malignant tumors. In addition to the morphologic information provided by the CT component of this hybrid modality,...

Brain tumor's 'grow-or-go' switch discovered

ScienceDaily Headlines — Sat, 13 Mar 2010 15:55:32 +0100

This study discovered that a molecule called miR-451 coordinates this grow-or-go behavior, which is closely linked to the cells' ability to invade and spread. Thus, the molecule might be a biomarker for predicting survival in patients with glioblastoma multiforme and may serve as a target to develop drugs to fight these tumors. (Source: ScienceDaily Headlines)

New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

New York Presbyterian Hospital - New support group

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Swedish Neuroscience Institute (in Seattle, Wash.) Brain Cancer Surgeon Publishes Major Feature Article in Scientific American MIND

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Sat, 13 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Discovery Of Brain Tumor's 'Grow-Or-Go' Switch

Health News from Medical News Today — Sat, 13 Mar 2010 08:00:00 +0100

Cancer cells in rapidly growing brain tumors must adjust to periods of low energy or die. When energy levels are high, tumor cells grow and proliferate. When levels are low, the cells grow less and migrate more. Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have discovered the switch responsible for this grow-or-go behavior. Their study shows that a molecule called miR-451 coordinates the change, and that the change is accompanied by slower cell proliferation and an increase in cell migration... (Source: Health News from Medical News Today)

Discovery Of Brain Tumor's 'Grow-Or-Go' Switch

Genetics News From Medical News Today — Sat, 13 Mar 2010 08:00:00 +0100

Dealing with death,

OrlandoSentinel: Medical Research — Sat, 13 Mar 2010 00:00:00 +0100

Too Many CT Scans?

Dr. Weil Q&A — Fri, 12 Mar 2010 16:36:23 +0100

I'm 60 and from age 35 I have probably had well over a dozen CT scans, first for nodules on lungs. I've also had scans of my brain, back and other areas. None turned up anything serious, but now I feel doomed to develop cancer! Is there is any "after-the-fact" help; any special diet or supplements that can help repair the damage from all these scans? Is this damage to tissue? Genes? (Source: Dr. Weil Q&A)

Johns Hopkins Doctor and Disaster Expert Says Resource Problems in Haiti Required Difficult Ethical Decision-Making-3/11/10

Johns Hopkins Medicine News — Fri, 12 Mar 2010 15:32:26 +0100

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Utility of Lymph Node Assessment for Atypical Spitzoid Melanocytic Neoplasms

Annals of Surgical Oncology — Fri, 12 Mar 2010 06:48:06 +0100

Conclusions Nodal status does not seem to convey the same prognosis that it does in standard melanoma. There may be a limited ability for progression within the nodal basin in patients with these lesions. This subset of patients would benefit from genetic data complementing histologic analysis. Content Type Journal ArticleCategory MelanomasDOI 10.1245/s10434-010-1022-3Authors Bahair Ghazi, Emory University Division of Surgical Oncology, Winship Cancer Institute Atlanta GA USAGrant W. Carlson, Emory University Division of Surgical Oncology, Winship Cancer Institute Atlanta GA USADouglas R. Murray, Emory University Division of Surgical Oncology, Winship Cancer Institute Atlanta GA USAKenneth W. Gow, Seattle Children’s Hospital Seattle WA USAAndrew Page, Emory Univer...

Timing and risk factors for new brain metastasis formation in patients initially treated only with Gamma Knife surgery.

Journal of Neurosurgery — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions The timing and number of new brain metastases developing in patients treated with GKS alone is not inconsequential. Those with 3 or more metastases at the time of radiosurgery and those with cancer histology other than non-small cell lung carcinoma were at greater risk of early formation of new brain metastasis. Frequent follow-up evaluations, such as at 3-month intervals, appears appropriate in this patient population, particularly in high-risk patients. When detected early, salvage treatments including repeat radiosurgery can be used to treat new brain metastasis. PMID: 20225924 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Glioma stem cells involved in tumor tissue remodeling in a xenograft model.

Journal of Neurosurgery — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions The results of this study indicated that the GFP transgenic nude mice model with GFP expression in essentially all tissues could be obtained by crossing nontransgenic athymic nude mice with transgenic GFP mice. This model should greatly expand our knowledge of glioma-host interactions. The data indicated that hGSCs might play a decisive role in tissue remodeling of gliomas as well. PMID: 20225923 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

High brain cancer rate likely to drop to normal in The Acreage, researcher says

OrlandoSentinel: Medical Research — Thu, 11 Mar 2010 18:56:00 +0100

The high rate of brain cancer in The Acreage probably will — like most cancer clusters in the country — eventually return to normal, a Nemours Center for Childhood Cancer Research official said Wednesday. "They come, they go. Nobody quite... (Source: OrlandoSentinel: Medical Research)

High brain cancer rate likely to drop to normal in Acreage

OrlandoSentinel: Medical Research — Thu, 11 Mar 2010 18:43:00 +0100

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The Genetics of Pediatric Brain Tumors

Current Neurology and Neuroscience Reports — Thu, 11 Mar 2010 18:26:48 +0100

Abstract Brain tumors are the most common childhood solid malignancy and the leading cause of cancer-related death in children. Medulloblastoma, ependymoma, supratentorial primitive neuroectodermal tumors, and pilocytic astrocytoma are the most prevalent types, all of which are clinically, histologically, and genetically heterogeneous. Despite an incomplete molecular understanding of these tumors, we have made significant headway in the past 5 years in identifying and classifying important genetic alterations and pathways central to the disease process. This review summarizes our current state of knowledge, emphasizes recent seminal findings in the field, and proposes future research efforts needed to further characterize the genetic basis of pediatric brain tumors. ...

OR-Live, Inc.: REMINDER: This Week on ORLive (February 26, 2010): ORLive Announces Awake Craniotomy Chosen by Viewers as ORLive Video of the Year, and Launches New Surgery Technology Channel From Covidien Surgical

Market Wire - Pharmaceuticals and Biotech — Thu, 11 Mar 2010 15:30:00 +0100

WEST HARTFORD, CT (MARKET WIRE) ORLive, your destination for live and on-demand surgery video, announces the viewer's choice for the first annual ORLive Video of the Year was for the Awake Craniotomy presented by Methodist University Hospital. The video was chosen from a pool of 200 broadcasts from 2009, which were narrowed 14 nominees. Methodist University Hospital was also nominated for the Virtual Brain Tumor Board where new cases are presented each week to a growing international audience. ORLive also launched a new Channel from Covidien Surgical this week, featuring Advances in Hemorrhoid Treatment and Technology. (Source: Market Wire - Pharmaceuticals and Biotech)

New Hope for Battling Brain Cancer (preview)

Scientific American Topic - Medical Technology — Thu, 11 Mar 2010 14:00:00 +0100

In May 2006 Dwayne Berg woke up on a gurney in a Seattle emergency room, an IV in his arm and a team of doctors and nurses working him up. The last thing the 42-year-old financial executive could remember was running on a treadmill at his gym, part of his regular fitness regimen. He had suffered a seizure and tumbled off the machine, and although he had not hurt himself in the fall, doctors had asked for an MRI scan of his brain to see if they could find a cause for the seizure.They did, and the news was not good: the scan showed a large mass in the left frontal lobe that turned out to be a malignant glioma, a brain cancer that is almost invariably fatal. Berg underwent standard treatment: an operation to remove the tumor, followed by chemotherapy and radiation to eradicate any cancer cell...

New Hope for Battling Brain Cancer (preview)

Scientific American - Official RSS Feed — Thu, 11 Mar 2010 14:00:00 +0100

New Hope for Battling Brain Cancer (preview)

Scientific American Topic - Biotechnology — Thu, 11 Mar 2010 14:00:00 +0100

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New Hope for Battling Brain Cancer (preview)

Scientific American Topic - Stem Cell Research — Thu, 11 Mar 2010 14:00:00 +0100

Gliomagenesis and the Use of Neural Stem Cells in Brain Tumor Treatment

Thu, 11 Mar 2010 13:49:34 +0100

(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))

Hormone replacement therapy now linked to cataracts

NaturalNews.com — Thu, 11 Mar 2010 07:00:00 +0100

(NaturalNews) For decades, hormone replacement therapy (HRT) was pushed by the medical establishment as a kind of youth elixir that offered all sorts of remarkable benefits. Take the hormones Big Pharma concocts from pregnant horses' urine and chemicals and middle-aged and older women would supposedly have better sex lives, fewer wrinkles, protection from heart attacks and no more hot flashes. Only, it was all a huge myth. In fact, as the years passed and rates of breast cancer soared in women who took HRT, the truth began to be revealed. HRT didn't protect health at all. In fact, it caused breast and ovarian cancer (http://www.naturalnews.com/027617_HRT_drugs_ovarian_cancer.html), upped heart attack risk and was even linked to brain shrinkage (http://www.naturalnews.com/025371_women_brain...

Dr. William Grant discusses healing power of Vitamin D on NaturalNews Talk Hour

NaturalNews.com — Thu, 11 Mar 2010 07:00:00 +0100

(NaturalNews) This week's NaturalNews Talk Hour features William Grant, Ph.D. as he reveals "The Power of Vitamin D and Ultraviolet Light". Discover how to reduce your risk for degenerative dis-eases. Our program runs this Thursday evening at 6pm Pacific / 9pm Eastern, and registration is FREE. Simply enter your email address in the registration form on the right column of this page and you'll receive call-in details for the broadcast.The NaturalNews Talk Hour is a "behind the scenes", up close and personal look at the most important issues of our time. Discover what the mainstream media hasn't told you about the secrets of optimal health, freedom and the pursuit of happiness. Jonathan Landsman, host of NaturalNews Talk Hour, says "The health care industry has mostly ignored the powerful b...

Researchers discover brain tumor's 'grow-or-go' switch

EurekAlert! - Medicine and Health — Thu, 11 Mar 2010 05:00:00 +0100

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Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update

Journal of Neuro-Oncology — Thu, 11 Mar 2010 02:43:20 +0100

Abstract To report long-term results for children with low-grade hypothalamic/chiasmatic gliomas treated on a phase II chemotherapy protocol. Between 1984 and 1992, 33 children with hypothalamic/chiasmatic LGGs received TPDCV chemotherapy on a phase II prospective trial. Median age was 3.0 years (range 0.3–16.2). Twelve patients (36%) underwent STRs, 14 (42%) biopsy only, and seven (21%) no surgery. Twenty patients (61%) had pathologic JPAs, nine (27%) grade II gliomas, and four (12%) no surgical sampling. Median f/u for surviving patients was 15.2 years (range 5.3–20.7); 20 of the 23 surviving patients had 14 or more years of follow-up. Fifteen-year PFS and OS were 23.4 and 71.2%, respectively. Twenty-five patients progressed, of whom 13 are NED, two are AWD,...

Characteristics of patients with brain metastases from lung cancer in a palliative care center

Supportive Care in Cancer — Thu, 11 Mar 2010 02:41:15 +0100

Conclusion Optimization of the quality of life in its final stages requires efficient palliative care, which involves considerable psychological, sociological, technical, and financial burdens. Palliative management of brain metastases requires a multidisciplinary approach performed by a well-trained neuro-oncology team, and it is important to avoid any treatment that is harmful or has a poor toxicity/efficacy ratio to avoid inappropriate prolongation of dying. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-010-0838-5Authors Ryuya Yamanaka, Kurume University Research Center for Innovative Cancer Therapy, School of Medicine 67 Asahimachi Kurume Fukuoka 830-0011 JapanHatsuyo Koga, Kurume University Palliative Care Center, School of Medicine K...

The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro

Cancer Chemotherapy and Pharmacology — Thu, 11 Mar 2010 02:38:49 +0100

Conclusion Vorinostat has the capacity to elicit CRT exposure, suggesting its usefulness as immunogenic antitumour agent. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00280-010-1302-4Authors Jürgen Sonnemann, University Children’s Hospital Jena Department of Paediatric Haematology and Oncology Jena GermanyStephanie Greßmann, University Children’s Hospital Jena Department of Paediatric Haematology and Oncology Jena GermanySabine Becker, University Children’s Hospital Jena Department of Paediatric Haematology and Oncology Jena GermanySusan Wittig, University Children’s Hospital Jena Department of Paediatric Haematology and Oncology Jena GermanyMareike Schmudde, Ernst Moritz Arndt University Institute for Immunology and Transfusion Medicin...

Advances in Pediatric Neurovirology

Current Neurology and Neuroscience Reports — Thu, 11 Mar 2010 02:24:10 +0100

Abstract Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been associated with chronic encephalopathy, encephalitis, demyelinating disease, tumors, and epilepsy. Older diagnostic techniques of biopsy, viral culture, electron microscopy, gel-based polymerase chain reaction (PCR), and viral titer quantification are being replaced with more rapid, sensitive, and specific real-time and microarray-based PCR technologies. Advances in neuroimaging technologies have provided for earlier recognition of CNS injury without elucidation of specific viral etiology. Although the mainstay therapy of ...

Sonic Hedgehog signaling in the mammalian brain

Journal of Neurochemistry — Thu, 11 Mar 2010 00:00:00 +0100

J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06642.x The discovery of a Sonic Hedgehog (Shh) signaling pathway in the mature vertebrate CNS has paved the way to the characterization of the functional roles of Shh signals in normal and diseased brain. Shh is proposed to participate in the establishment and maintenance of adult neurogenic niches and to regulate the proliferation of neuronal or glial precursors in several brain areas. Consistent with its role during brain development, misregulation of Shh signaling is associated with tumorigenesis while its recruitement in damaged neural tissue might be part of the regenerating process. This review focuses on the most recent data of the Hedgehog pathway in the adult brain and its relevance as a novel therapeutic approach for brain diseases i...

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Primary large cell neuroendocrine carcinoma of the vagina: Cytomorphology of previously unreported case

Diagnostic Cytopathology — Thu, 11 Mar 2010 00:00:00 +0100

In this report, we describe a case of LCNEC of the vagina, which is believed to be the first case to date in the English literature. The patient is a 53-year old gravida 3, para 2, African-American woman who had a 4 month history of severe pelvic pain and difficulty voiding and was found to have a firm plate-like mass on the anterior vaginal wall. Thin prep of vaginal swap was interpreted as atypical glandular cells; however, the biopsies showed a large cell neuroendocrine carcinoma which was confirmed by diffuse strong immunoreactivity to AE1/3, CAM5.2, CK7, and CD56 in the tumor cells. Subsequent clinical workup showed that the patient also had numerous metastatic nodules in the bilateral lungs and a vaginal-urethral fistula caused by the tumor. The patient underwent palliative radiation...

Investigators At University Of Chicago, Brain Tumor Center Have Published New Data On Cancer Gene Therapy

Cancercompass News: Other Cancer — Thu, 11 Mar 2010 00:00:00 +0100

A report, 'Virotherapy against malignant glioma stem cells,' is newly published data in Cancer Letters. Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo-and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success, researchers in the United States report. (Source: Cancercompass News: Other Cancer)

Words of Wisdom Wednesday: Seven Years Later.

Psychology Today Relationships Center — Wed, 10 Mar 2010 16:55:54 +0100

My father committed suicide 7 years ago today. I wanted to mark the day, and since you've already read about my journey as a daughter, I give you my mother's journey - in her own words. My parents were married for almost 25 years, and were the happiest and most-in-love couple I've ever met. Here is her story...Suicide Survivor. When I first heard that term, it totally confused me. I couldn't figure out how anyone could "survive" a suicide. Of course, I was under the incorrect assumption that it was their own suicide they were surviving, not someone else's.Then came March 10, 2003, the day I joined the ranks of the suicide survivors. It's fitting that Melissa asked me to write this today, on the 7th anniversary of my husband's death.My husband, Brian Blake, was diagnosed w...

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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ImmunoCellular Therapeutics` Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma

Clinical Trials And Noteworthy Treatments For Brain Tumors — Wed, 10 Mar 2010 16:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Expression and clinical significance of EGFL7 in malignant glioma

Journal of Cancer Research and Clinical Oncology — Wed, 10 Mar 2010 16:10:21 +0100

Conclusions Our data suggest that EGFL7 expression is a novel predictive factor for the clinical progression of malignant glioma, and may constitute a therapeutic target for anti-angiogenesis therapy in patients with the disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0832-9Authors Chun-hai Huang, Central South University Department of Neurosurgery, Xiangya Hospital No 87 Xiangya Road Changsha 410008 ChinaXue-jun Li, Central South University Department of Neurosurgery, Xiangya Hospital No 87 Xiangya Road Changsha 410008 ChinaYi-zeng Zhou, Jishou University Department of Neurosurgery, First Affiliated Hospital Jishou 416000 ChinaYong Luo, Jishou University Department of Neurosurgery, First Affiliated Hospital Jishou 416000 ChinaCui L...

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

Journal of Neuro-Oncology — Wed, 10 Mar 2010 16:00:41 +0100

This study was conducted to determine the side effects and maximum tolerated dose (MTD) of bortezomib in patients with recurrent malignant glioma. Separate dose escalations were conducted in patients taking or not taking enzyme-inducing anti-seizure drugs (+/−EIASD). The starting dose in both groups was 0.9 mg/m2 intravenously twice weekly for the first three of each 4 week cycle. Imaging assessment of response was carried out and Plasma 20S proteasome activity inhibition and imaging was conducted to monitor efficacy. The 66 patients enrolled had a median age of 51 years, median KPS of 90%, and 77% had glioblastoma multiforme. The MTD in the −EIASD group was 1.70 mg/m2 based on grade 3 thrombocytopenia, sensory neuropathy and fatigue. In the +EIASD group escala...

An endodermal cyst mimicking an intra-axial tumor in the medulla oblongata

Child's Nervous System — Wed, 10 Mar 2010 15:43:26 +0100

Discussion Total resection of endodermal cysts in the medulla oblongata is recommended, despite their location and adhesion to surrounding structures, due to its frequent recurrence. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00381-010-1109-yAuthors Jin Mo Cho, Yonsei University College of Medicine Department of Neurosurgery, Brain Research Institute 134, Shinchon-dong, Seodaemoon-gu Seoul 120-752 Republic of KoreaJung Yong Ahn, Yonsei University College of Medicine Department of Neurosurgery, Brain Research Institute 134, Shinchon-dong, Seodaemoon-gu Seoul 120-752 Republic of KoreaSun Ho Kim, Yonsei University College of Medicine Department of Neurosurgery, Brain Research Institute 134, Shinchon-dong, Seodaemoon-gu Seoul 120-752 Republic of KoreaKy...

Surgical morbidity and mortality of pediatric brain tumors: a single center audit

Child's Nervous System — Wed, 10 Mar 2010 15:43:22 +0100

Conclusion These overall morbidity rates are comparable to other published mixed case series. The surgical mortality rate was 0.8%; this is comparable to the lowest rates reported for high-volume neurosurgical centers. We encourage other neurosurgical centers to collect, analyze, and publish their data. These data can then serve as a basis for comparison with other pediatric neurosurgical centers and will eventually lead to an improvement of pediatric neurosurgical practice and patient care. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00381-010-1086-1Authors F. W. Neervoort, VU University Medical Center Neurosurgical Center Amsterdam Amsterdam The NetherlandsW. J. R. Van Ouwerkerk, VU University Medical Center Neurosurgical Center Amsterdam Amst...

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Walnut Extract Inhibits LPS-induced Activation of Bv-2 Microglia via Internalization of TLR4: Possible Involvement of Phospholipase D2

Inflammation — Wed, 10 Mar 2010 15:42:31 +0100

Abstract Walnuts are a rich source of essential fatty acids, including the polyunsaturated fatty acids alpha-linolenic acid and linoleic acid. Essential fatty acids have been shown to modulate a number of cellular processes in the brain, including the activation state of microglia. Microglial activation can result in the generation of cytotoxic intermediates and is associated with a variety of age-related and neurodegenerative conditions. In vitro, microglial activation can be induced with the bacterial cell wall component lipopolysaccharide (LPS). In the present study, we generated a methanolic extract of English walnuts (Juglans regia) and examined the effects of walnut extract exposure on LPS-induced activation in BV-2 microglial cells. When cells were treated with walnu...

Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children’s Oncology Group study

Cancer Causes and Control — Wed, 10 Mar 2010 13:22:28 +0100

Conclusions Head injury and exposure to diagnostic head X-rays were not associated with medulloblastoma/PNET in this study. Future studies should investigate all imaging procedures with ionizing radiation exposure including computed tomography scans and utilize radiation dose estimations. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9529-2Authors Saira Khan, Drexel University School of Public Health Department of Epidemiology and Biostatistics Philadelphia PA USAAlison A. Evans, Drexel University School of Public Health Department of Epidemiology and Biostatistics Philadelphia PA USALucy Rorke-Adams, University of Pennsylvania School of Medicine Departments of Pathology, Neurology, and Pediatrics Philadelphia PA USAManuela A. Orjuela, Co...

Effects on the visual system might contribute to some of the cognitive deficits of cancer chemotherapy-induced 'chemo-fog'

Journal of Clinical Pharmacy and Therapeutics — Wed, 10 Mar 2010 00:00:00 +0100

The diminution in certain aspects of cognitive function that is reported to occur in some patients during or after adjuvant cancer chemotherapy is variously known as 'chemo-fog', 'chemo-brain' or other such term. In addition to reported deficits in attention, concentration and other functions, most, if not all, of the studies report deficits involving visual-spatial function or visual memory. Since the visual system is part of the nervous system, it seems reasonable to ask if it is susceptible to some of the deleterious effects produced by adjuvant chemotherapeutic drugs. We propose here the possibility that some portion of the vision-related aspects of the 'chemo-fog' spectrum of cognitive deficits results from a direct action of the adjuvant drugs on the visual system or from drug/drug o...

Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines

BMC Cancer — Wed, 10 Mar 2010 00:00:00 +0100

Conclusion: PSA-NCAM represents a valuable biomarker for the prognosis of GBM patients. (Source: BMC Cancer)

A 31-Year-Old Woman With a Transformed Low-grade Glioma [Clinical Crossroads]

JAMA — Tue, 09 Mar 2010 20:50:43 +0100

Low-grade gliomas in adults have an incidence of 0.8 to 1.2 per 100 000, and their causes are unknown. Despite their histological classification as low-grade, they cannot be cured by any current treatment mode, and no class I evidence exists to guide initial treatment of these tumors. Median survival ranges between 7.5 years and 10 years, with a 5-year survival probability between 55% and 86%. The prognosis depends on age, World Health Organization (WHO) tumor grade, Karnofsky performance score, cytological type (oligodendroglioma vs astrocytoma), and, potentially, the extent of resection. Oligodendrogliomas with loss of heterozygosity on chromosomes 1p and 19q have a distinctly more favorable prognosis and therapeutic response rate. Low-grade tumors progress to high-grade gliomas wit...

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Genomics Illuminates a Deadly Brain Cancer [Medical News & Perspectives]

JAMA — Tue, 09 Mar 2010 20:50:43 +0100

(Source: JAMA)

Gliomas [JAMA Patient Page]

JAMA — Tue, 09 Mar 2010 20:50:43 +0100

(Source: JAMA)

Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 09 Mar 2010 17:27:19 +0100

To analyze the in vivo structure of antigen-specific immunological synapses during an effective immune response, we established brain tumors expressing... (Source: Proceedings of the National Academy of Sciences)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma.

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 09 Mar 2010 10:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1+/- mouse cerebellum

BioMed Central — Tue, 09 Mar 2010 00:00:00 +0100

Conclusions: As a whole, our findings indicate that IGF-I overexpression in neural precursors leads to brain overgrowth and fosters external granular layer (EGL) proliferative lesions through a mechanism favoring proliferation over terminal differentiation, acting as a landscape for tumor growth. Understanding the molecular events responsible for cerebellum development and their alterations in tumorigenesis is critical for the identification of potential therapeutic targets. (Source: BioMed Central)

Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity

BMC Neuroscience - Latest articles — Tue, 09 Mar 2010 00:00:00 +0100

Conclusions: Our data show that targeted CNS cell therapy requires blood-brain barrier disruption. MRI-detectable cytotoxic anti-neoplastic cells can be forced to transverse the BBB and accumulate in the perivascular space. The virtual absence of toxicity, the high anti-tumor activity of TALL-104, and the clinical feasibility of human osmotic BBBD suggest that this approach may be adopted to treat brain or spinal cord tumors. In addition, BBBD may favor CNS entry of other cells that normally lack CNS tropism. (Source: BMC Neuroscience - Latest articles)

Flavonoids and Astrocytes Crosstalking: Implications for Brain Development and Pathology.

Neurochemical Research — Tue, 09 Mar 2010 00:00:00 +0100

Authors: Nones J, Stipursky J, Costa SL, Gomes FC Flavonoids are naturally occurring polyphenolic compounds that are present in a variety of fruits, vegetables, cereals, tea, and wine, and are the most abundant antioxidants in the human diet. Evidence suggests that these phytochemicals might have an impact on brain pathology and aging; however, neither their mechanisms of action nor their cell targets are completely known. In the mature mammalian brain, astroglia constitute nearly half of the total cells, providing structural, metabolic, and trophic support for neurons. During the past few years, increasing knowledge of these cells has indicated that astrocytes are pivotal characters in neurodegenerative diseases and brain injury. Most of the physiological benefits of flavonoids are ge...

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Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor {alpha} and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets [Pediatric Oncology]

Journal of Clinical Oncology — Mon, 08 Mar 2010 23:01:29 +0100

Conclusion To our knowledge, our data provides the first, comprehensive high-resolution genomic analysis of pediatric DIPG. Our findings of recurrent involvement of the PDGFR pathway as well as defects in DNA repair pathways coupled with gain of PARP-1 highlight two potential, biologically based, therapeutic targets directed specifically at this devastating disease. (Source: Journal of Clinical Oncology)

Cancer of the Nervous System: 2010 [Editorial]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

(Source: Archives of Neurology)

New Insights Into Susceptibility to Glioma [Neurological Review]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

The study of inherited susceptibility to cancer has been one of the most informative areas of research in the past decade. Most of the cancer genetics studies have been focused on the common tumors such as breast and colorectal cancers. As the allelic architecture of these tumors is unraveled, research attention is turning to other rare cancers such as glioma, which are also likely to have a major genetic component as the basis of their development. In this brief review we discuss emerging data on glioma whole genome–association searches to identify risk loci. Two glioma genome-wide association studies have so far been reported. Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872)....

Recent Advances in Therapy for Glioblastoma [Neurological Review]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

This article will review recent advances in therapy for glioblastoma, including surgery, radiotherapy, cytotoxic chemotherapies, molecularly targeted agents, and immunotherapy; the role of antiangiogenic agents in the treatment of glioblastoma is discussed in a separate article in this issue of the Archives. (Source: Archives of Neurology)

Bevacizumab for Malignant Gliomas [Neurological Review]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Malignant gliomas are the most common and aggressive primary brain tumors in adults. Despite optimal treatment with surgery, radiotherapy, and temozolomide, tumor recurrences are frequent and patients with malignant gliomas continue to have poor prognoses. Malignant gliomas are often highly vascularized, and significant advances have been made in the last few decades in our understanding of the mechanisms of tumor angiogenesis. Recently, bevacizumab, an antibody against vascular endothelial growth factor, has demonstrated significant activity in recurrent glioblastomas, resulting in US Food and Drug Administration approval and raising the prospect for other antiangiogenic drugs now entering clinical trials. (Source: Archives of Neurology)

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New Strategies in the Management of Leptomeningeal Metastases [Neurological Review]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

The management of patients with leptomeningeal metastases (LM) is multifaceted and complex. Even with an aggressive approach, therapeutic outcomes are uniformly disappointing. This is because of the relentless growth of the central nervous system (CNS) and/or the systemic cancers, or their lethal complications. Advances in the understanding of the homing of cancer cells to the CNS, and of cancer metastasis in general, and more effective anticancer drugs that are adequately delivered to the CNS and cerebrospinal fluid (CSF) are needed to improve outcomes for patients with LM. These advances may lead to better treatments for this disease and, ultimately, its prevention. (Source: Archives of Neurology)

A Phase 1 Trial of ABT-510 Concurrent With Standard Chemoradiation for Patients With Newly Diagnosed Glioblastoma [Clinical Trials]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusions ABT-510, at subcutaneous doses up to 200 mg/d, is tolerated well with concurrent temozolomide and radiotherapy in patients with newly diagnosed glioblastoma, and low-density arrays provide a useful method of exploring gene expression profiles. (Source: Archives of Neurology)

Morphological Characteristics of Brain Tumors Causing Seizures [Original Contribution]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusions The influence of size and location of the tumors on their propensity to cause seizures varies with the grade of the tumor. In high-grade gliomas, rapidly growing tumors, particularly those situated in deeper structures, present with non–seizure-related symptoms. In low-grade gliomas, lesions in the temporal lobe or the insula grow large without other symptoms and eventually cause seizures. Quantitative image analysis allows for the mapping of regions in each group that are more or less susceptible to seizures. (Source: Archives of Neurology)

Efficacy and Safety of Levetiracetam in Patients With Glioma: A Clinical Prospective Study [Original Contribution]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusion The results of this study provide good evidence that levetiracetam is efficacious and safe in patients with epilepsy due to glioma. (Source: Archives of Neurology)

Malignant Astrocytomas: A System Disease [From JAMA]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

(Source: Archives of Neurology)

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Papilledema as the Sole Magnetic Resonance Imaging Finding in Leptomeningeal Metastasis [Images in Neurology]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

(Source: Archives of Neurology)

Diffuse Brain Stem Glioma [Images in Neurology]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

(Source: Archives of Neurology)

Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma [Observation]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusion The initial results are promising and indicate that FET PET is a valuable and applicable tool for the imaging of high-grade glioma. (Source: Archives of Neurology)

21. MR perfusion imaging in diagnostics of brain pathologies

Clinical Neurophysiology — Mon, 08 Mar 2010 18:13:03 +0100

The knowledge of parameters which describe oxygen and nutrients supply to tissues is essential from standpoint of diagnostics and follow-up of pathologies of brain. Due to their low spatial resolution MR angiographic techniques cannot visualize blood flow inside bulk tissue. In order to obtain the hemodynamic parameters which describe perfusion, MR perfusion imaging use drop in tissue signal during the first pass of contrast agent. Decrease in MR signal is proportional to intravascular concentration of contrast agent, which provides basis for calculation of regional cerebral volume (rCBV), regional cerebral flow (rCBF) and mean transition time (MTT) and corresponding maps of these parameters. Such maps can pinpoint to changes in perfusion of brain tissue which can be consequence or cause o...