MedWorm: Brain Cancers

Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences

Neurogastroenterology and Motility — Thu, 02 Feb 2012 20:48:30 +0100

Conclusions & Inferences The findings suggest a valuable therapeutic role of LAB especially when incorporated into alginate beads for the treatment of CFS. (Source: Neurogastroenterology and Motility)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Call to 'tax sugar like alcohol'

NHS News Feed — Thu, 02 Feb 2012 18:00:00 +0100

This article will be of interest to food scientists, health policy makers and the public alike, but the use of strategies to restrict the consumption of added sugar is complicated and, indeed controversial. The implications of such moves would need to be considered in both medical and societal terms. They would need both medical evidence to support their effectiveness and assurance that the public would accept drastic changes, such as age limits on buying sweets. For example, in recent years, Denmark has imposed taxes on fatty foods, a move that has divided opinions greatly. It is generally accepted that added sugar or excessive sugar consumption is bad for health and dietitians advise restricting sugar intake to the occasional “treat”. However, to what extent sugar is directly to blam...

Noninvasive imaging technique may replace risky brain tumor biopsies

HemOncToday.com — Thu, 02 Feb 2012 13:24:51 +0100

(Source: HemOncToday.com)

Health Highlights: Feb. 1, 2012

Primary Care News - Doctors Lounge — Wed, 01 Feb 2012 16:03:00 +0100

Ground Beef-Related Salmonella Outbreak Over: CDC ALS Researcher Dies of Disease He Studied Breast Cancer Charity Severs Ties With Planned Parenthood Study Identifies New Location for Brain Speech Center Indoor Tanning Salons Lie About Health Risks: Investigation (Source: Primary Care News - Doctors Lounge)

Defects In The Packaging Of DNA In Malignant Brain Tumors

Health News from Medical News Today — Wed, 01 Feb 2012 08:00:00 +0100

Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently available treatment methods are frequently not very effective against this type of cancer. Glioblastoma can affect people of all ages, but is less common in children than in adults... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Genetic Breakthrough For Brain Cancer In Children

Health News from Medical News Today — Wed, 01 Feb 2012 08:00:00 +0100

An international research team led by the Research Institute of the McGill University Health Centre (RI MUHC) has made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children - a fatal cancer of the brain that is unresponsive to chemo and radiotherapy treatment... (Source: Health News from Medical News Today)

Brain metastases from hepatocellular carcinoma: Clinical features and prognostic factors

BMC Cancer — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: BM from HCC is rare and associated with an extremely poor prognosis. However, patients with a low RPA class may benefit from aggressive treatment. The clinical implication of extracranial metastases in HCC patients with BM needs further assessment. (Source: BMC Cancer)

JCI online early table of contents: Feb. 1, 2012

EurekAlert! - Cancer — Wed, 01 Feb 2012 05:00:00 +0100

(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Feb. 1, 2012, in the JCI: "A thought-provoking new therapeutic target for brain cancer?"; "Answers to age-old questions surrounding fat cell cancer"; "Access denied: dense matrix blocks immune cell path to cancer cells"; "Finally, experimental transformation of a primary cell into a tumor cell by the cancer-causing virus KSHV"; and "Taking on features of cancer cells." (Source: EurekAlert! - Cancer)

A thought-provoking new therapeutic target for brain cancer?

EurekAlert! - Cancer — Wed, 01 Feb 2012 05:00:00 +0100

(Journal of Clinical Investigation) Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. As reported in the Journal of Clinical Investigation, researchers have now identified the protein SULF2 as a potential new therapeutic target for the treatment of GBM. (Source: EurekAlert! - Cancer)

[Cancer and Society] Medikidz explain cancer

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

The Medikidz are a gang of superheroes with a mission—to explain medical information to children in plain language. In a series that includes titles such as What's up with Lyndon? Medikidz explain osteosarcoma, these five superheroes help kids understand brain tumours, melanoma, and several other types of cancer that affect children and families. Each 32-page book is designed as a graphic novel with vibrant illustrations and recurring themes and characters to keep kids engaged with the medical content. (Source: The Lancet Oncology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Childhood Brain Tumors Linked To Newly Discovered Mutations

Health News from Medical News Today — Tue, 31 Jan 2012 17:00:00 +0100

A recent study published in the online edition of the scientific journal Nature Genetics of rare, lethal childhood tumors of the brainstem has revealed that almost 80% of tumors contain gene mutations that have previously not been associated with cancer. According to early evidence, gene alterations also implicate other aggressive pediatric brain tumors. The results provide a significant insight into a poorly understood tumor that has a mortality rate of over 90% in patients within two years... (Source: Health News from Medical News Today)

Monoallelic Expression Determines Oncogenic Progression and Outcome in Benign and Malignant Brain Tumors

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in specific cancer-related genes, and the clinical consequences of MAE in brain tumors. We also used targeted genotyping to examine the role of tumor-related genes in brain tumor development and specifically examined the clinical consequences of MAE at TP53 and IDH1. The genome-wide rate of tumor MAE was higher than in previously described normal tissue and increased with specific tumor grade. Oncogenes, but not tumor suppressors, exhibited significantly higher MAE in high-grade c...

Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

Brain tissue biopsies are required to histologically diagnose brain tumors, but current approaches are limited by tissue characterization at the time of surgery. Emerging technologies such as mass spectrometry imaging can enable a rapid direct analysis of cancerous tissue based on molecular composition. Here, we illustrate how gliomas can be rapidly classified by desorption electrospray ionization-mass spectrometry (DESI-MS) imaging, multivariate statistical analysis, and machine learning. DESI-MS imaging was carried out on 36 human glioma samples, including oligodendroglioma, astrocytoma, and oligoastrocytoma, all of different histologic grades and varied tumor cell concentration. Gray and white matter from glial tumors were readily discriminated and detailed diagnostic information could ...

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

In this study, we developed and evaluated small molecule inhibitors of Taspase1 as a new candidate class of therapeutic modalities. Genetic deletion of Taspase1 in the mouse produced no overt deficiencies, suggesting the possibility of a wide therapeutic index for use of Taspase1 inhibitors in cancers. We defined the peptidyl motifs recognized by Taspase1 and conducted a cell-based dual-fluorescent proteolytic screen of the National Cancer Institute diversity library to identify Taspase1 inhibitors (TASPIN). On the basis of secondary and tertiary screens the 4-[(4-arsonophenyl)methyl]phenyl] arsonic acid NSC48300 was determined to be the most specific active compound. Structure–activity relationship studies indicated a crucial role for the arsenic acid moiety in mediating Taspase1 inhibi...

Brain metastases from colorectal cancer: The role of surgical resection in selected patients

Colorectal Disease — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion: Aggressive surgical resection in selected patients with brain metastases from colorectal cancer may prolong survival, even in the presence of extracranial metastatic lesions. (Source: Colorectal Disease)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Stunning 7-Year Survival Difference in Brain Tumor TrialStunning 7-Year Survival Difference in Brain Tumor Trial

Medscape Today Headlines — Mon, 30 Jan 2012 17:23:42 +0100

A study of patients with oligodendrogliomas has a practice-changing result. Medscape Medical News (Source: Medscape Today Headlines)

Genetic breakthrough for brain cancer in children

ScienceDaily Headlines — Mon, 30 Jan 2012 15:25:25 +0100

Scientists have made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children. The mutations were found to be involved in DNA regulation, which could explain the resistance to traditional treatments, and may have significant implications on the treatment of other cancers. (Source: ScienceDaily Headlines)

New MRI Technique Helps Diagnose Gliomas

Diagnostic Imaging — Mon, 30 Jan 2012 09:30:01 +0100

A new magnetic resonance spectroscopy (MRS) technique provides a definitive diagnosis of brain cancer based on imaging of a protein associated with a mutated gene found in 80 percent of low- and intermediate-grade gliomas, according to a new study published January 26 in Nature Medicine. (Source: Diagnostic Imaging)

Mutations Tied To Aggressive Childhood Brain Tumors Revealed By Cancer Sequencing Initiative

Health News from Medical News Today — Mon, 30 Jan 2012 09:00:00 +0100

Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. The findings from the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (PCGP) offer important insight into a poorly understood tumor that kills more than 90 percent of patients within two years... (Source: Health News from Medical News Today)

Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model.

Cell Cycle — Mon, 30 Jan 2012 08:36:30 +0100

In this study, we demonstrated that the Salmonella typhimurium A1-R tumor-targeting strain can inhibit and eradicate human glioma in an orthotopic nude-mouse model. S. typhimurium A1-R was administered by injection through a craniotomy open-window or intravenously in nude mice. To establish the model, 2 x 105 U87-RFP human glioma cells were injected stereotactically into the mouse brain through the craniotomy open window. Two weeks after glioma-cell implantation, mice were treated with S. typhimurium A1-R [2 x 10 ( 7) CFU/200 μl intravenous injection (i.v.) or 1 x 10 ( 6) CFU/1 μl intracranial injection (i.c.)] once a week for 3 weeks. Brain tumors were observed by fluorescence imaging through the craniotomy open window over time. S. typhimurium A1-R, administered i.c., inhibited brain t...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Patient Care Could Be Revolutionized By Diagnostic Brain Tumor Test

Health News from Medical News Today — Mon, 30 Jan 2012 08:00:00 +0100

Researchers at UT Southwestern Medical Center have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy. This new magnetic resonance spectroscopy (MRS) technique provides a definitive diagnosis of cancer based on imaging of a protein associated with a mutated gene found in 80 percent of low- and intermediate-grade gliomas. Presence of the mutation also means a better prognosis... (Source: Health News from Medical News Today)

Care and support needs of patients and carers early post-discharge following treatment for non-malignant brain tumour: establishing a new reality

Supportive Care in Cancer — Mon, 30 Jan 2012 06:32:03 +0100

Conclusion Participants had a tendency to rely on informal support networks but identified unmet information and support needs particularly for carers. These findings highlight the need for more efficient and effective discharge preparation, referral to services and supports, provision of timely information and support for family caregivers of those with brain tumour. Content Type Journal ArticleCategory Original ArticlePages 1-16DOI 10.1007/s00520-012-1383-1Authors Petrea Cornwell, Metro North Health Service District, Queensland Health, Chermside, AustraliaBronwyn Dicks, School of Health and Rehabilitation Sciences, The University of Queensland, St. Lucia, AustraliaJennifer Fleming, School of Health and Rehabilitation Sciences, The University of Queensland, St. Luc...

Genetic breakthrough for brain cancer in children

EurekAlert! - Social and Behavioral Science — Mon, 30 Jan 2012 05:00:00 +0100

(McGill University Health Centre) An international research team led by the Research Institute of the MUHC in Montreal has made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children. The mutations were found to be involved in DNA regulation, which could explain the resistance to traditional treatments, and may have significant implications on the treatment of other cancers. (Source: EurekAlert! - Social and Behavioral Science)

Defects in the packaging of DNA in malignant brain tumors

EurekAlert! - Medicine and Health — Mon, 30 Jan 2012 05:00:00 +0100

(Helmholtz Association of German Research Centres) In children with glioblastoma, a particularly aggressive brain tumor, scientists have discovered mutations that affect the function of proteins known as histones. Histones serve as coils around which the DNA wraps. At the same time, histones regulate gene activity. Mutations in histone genes have never before been tied to a disease. Scientists of the German Cancer Research Center, Heidelberg University Hospitals and McGill University in Canada have now reported their findings in Nature. (Source: EurekAlert! - Medicine and Health)

Transcriptional factors for Epithelial–Mesenchymal Transition are Associated with Mesenchymal Differentiation in Gliosarcoma

Brain Pathology — Mon, 30 Jan 2012 05:00:00 +0100

AbstractGliosarcoma is a rare variant of glioblastoma characterized by a biphasic pattern of glial and mesenchymal differentiation. It is unclear whether mesenchymal differentiation in gliosarcomas is due to extensive genomic instability and/or to a mechanism similar to epithelial–mesenchymal transition (EMT). In the present study, we assessed 40 gliosarcomas for immunoreactivity of Slug, Twist, MMP‐2, and MMP‐9, which are involved in EMT in epithelial tumors. Nuclear Slug expression was observed in >50% of neoplastic cells in mesenchymal tumor areas of 33 (83%) gliosarcomas, but not in glial areas (P < 0.0001). Nuclear Twist expression was observed in >50% of neoplastic cells in mesenchymal tumor areas of 35 (88%) gliosarcomas, but glial tumor areas were largely negative ex...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors

ScienceDaily Headlines — Sun, 29 Jan 2012 20:10:10 +0100

A cancer sequencing initiative has discovered mutations tied to aggressive childhood brain tumors. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. (Source: ScienceDaily Headlines)

Experts recommend genetic counseling for young sarcoma patients

Thrive, Children's Hospital Boston — Sun, 29 Jan 2012 13:41:39 +0100

Genetic testing may help sarcoma patients and their famlies know their risk of other cancers later in life If your child is diagnosed with a sarcoma—a tumor in connective tissue like muscles or bones—it’s natural to become totally focused on his immediate recovery. But what if beating sarcoma wasn’t the only time your child might face cancer? Data shows that there is a link between sarcomas and Li-Fraumeni syndrome, a rare condition that raises a person’s risk of developing one or more cancers to as high as 85 percent. Cancers typically diagnosed in patients with Li-Fraumeni syndrome include breast cancer, sarcomas, brain tumors, acute leukemia and adrenal cortical carcinoma. Recently, the list has been expanded to include colon cancer and stomach cancer. Li-Fraumeni syndrome m...

Brain metastasis from colorectal cancer: Prognostic factors and survival

Journal of Surgical Oncology — Sun, 29 Jan 2012 13:15:24 +0100

ConclusionsThe prognosis of patients with BM from CRC was associated with the curability of the therapy for BM, number of metastatic organs, and the serum CEA level. The modality of treatment had no significant impact on the outcome. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors

EurekAlert! - Medicine and Health — Sun, 29 Jan 2012 05:00:00 +0100

(St. Jude Children's Research Hospital) Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. (Source: EurekAlert! - Medicine and Health)

Brain metastases: the need for a more tailored approach in non-small-cell lung cancer patients

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:17 +0100

Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s12094-012-0754-xAuthors Pablo Martínez, Medical Oncology Department, Vall d’Hebron University Hospital, P. Vall d’Hebron, 119-129, ES-08035 Barcelona, SpainEnriqueta Felip, Medical Oncology Department, Vall d’Hebron University Hospital, P. Vall d’Hebron, 119-129, ES-08035 Barcelona, Spain Journal Clinical and Translational OncologyOnline ISSN 1699-3055Print ISSN 1699-048X Journal Volume Volume 14 Journal Issue Volume 14, Number 1 (Source: Clinical and Translational Oncology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Evaluation of biocompatibility and anti-glioma efficacy of doxorubicin and irinotecan drug-eluting bead suspensions in alginate

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:16 +0100

Discussion We conclude that the alginate suspension of irinotecan DEBs can be considered safe and effective in a clinical setting. Content Type Journal ArticleCategory Research ArticlesPages 50-59DOI 10.1007/s12094-012-0761-yAuthors Silke Glage, Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyAndrew L. Lewis, Biocompatibles UK Ltd., Farnham Business Park Weydon Lane, Farnham, Surrey, GU9 8QL UKPatricia Mertens, International Neuroscience Institute, Rudolf-Pichlmayrstr. 4, 30625 Hannover, GermanySteffen Baltes, International Neuroscience Institute, Rudolf-Pichlmayrstr. 4, 30625 Hannover, GermanyPeter Geigle, CellMed AG, Industriestrasse 19, 63755 Alzenau, GermanyThomas Brinker, Inte...

Predicting compliance and survival in palliative whole-brain radiotherapy for brain metastases

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:15 +0100

Conclusions Results suggest that the geriatric tools analysed could offer information on brain palliative radiotherapy complementary to that offered by the more usual tools. It will be interesting to study if our data could be extrapolated to the general palliative oncological field. Content Type Journal ArticleCategory Research ArticlesPages 43-49DOI 10.1007/s12094-012-0760-zAuthors Sebastià Sabater, Department of Radiation Oncology, Complejo Hospitalario Universitario, C/Hermanos Falcó, 37, ES-02006 Albacete, SpainEncarna Mur, Department of Radiation Oncology, Sant Joan University Hospital, Reus, Tarragona, SpainKatrin Müller, Department of Radiation Oncology, Sant Joan University Hospital, Reus, Tarragona, SpainMeritxell Arenas, Department of Radiation Oncolog...

Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:10 +0100

Conclusions NSCLC patients with brain metastasis treated by brain surgery followed by radiotherapy may have a higher chance of relapse when the tumour has methylation of the MGMT promoter region. Content Type Journal ArticleCategory Research ArticlesPages 31-35DOI 10.1007/s12094-012-0758-6Authors Kenji Hashimoto, Neurosurgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanYoshitaka Narita, Neurosurgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanYuko Matsushita, Neurosurgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanYasuji Miyakita, Neurosurgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanMakoto...

μMLC-LINAC radiosurgery for intracranial meningiomas of complex shape

Acta Neurochirurgica — Sat, 28 Jan 2012 16:50:58 +0100

Conclusions LINAC radiosurgery using a micro multi-leaf collimator for complex shaped intracranial meningiomas is effective yielding a high local tumor control, whereas the treatment-related morbidity remains low. Content Type Journal ArticleCategory Clinical ArticlePages 1-6DOI 10.1007/s00701-012-1278-4Authors Faycal El Majdoub, Department of Stereotaxy and Functional Neurosurgery, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, GermanyMoataz Elawady, Department of Stereotaxy and Functional Neurosurgery, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, GermanyChristian Bührle, Department of Stereotaxy and Functional Neurosurgery, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, GermanyMustapha El-Khatib, Dep...

Diagnostic brain tumor test could revolutionize care of patients with low-grade gliomas

UT Southwestern Medical Center News — Sat, 28 Jan 2012 10:53:06 +0100

Researchers have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. (Source: UT Southwestern Medical Center News)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Balancing self‐renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells

BioEssays — Fri, 27 Jan 2012 21:40:09 +0100

AbstractBalancing self‐renewal and differentiation of stem cells is an important issue in stem cell and cancer biology. Recently, the Drosophila neuroblast (NB), neural stem cell has emerged as an excellent model for stem cell self‐renewal and tumorigenesis. It is of great interest to understand how defects in the asymmetric division of neural stem cells lead to tumor formation. Here, we review recent advances in asymmetric division and the self‐renewal control of Drosophila NBs. We summarize molecular mechanisms of asymmetric cell division and discuss how the defects in asymmetric division lead to tumor formation. Gain‐of‐function or loss‐of‐function of various proteins in the asymmetric machinery can drive NB overgrowth and tumor formation. These proteins control either the...

MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors

Journal of Neuro-Oncology — Fri, 27 Jan 2012 17:56:38 +0100

The objective of this study was to retrospectively investigate MGMT promoter hypermethylation status for a series of 350 human brain tumors, including 275 gliomas of different malignancy grade, 21 glioblastoma multiforme (GBM) cell lines, and 75 non-glial tumors. The analysis was performed by methylation-specific PCR and capillary electrophoresis. MGMT expression at the protein level was also evaluated by both immunohistochemistry (IHC) and western blotting analysis. Associations of MGMT hypermethylation with IDH1/IDH2 mutations, EGFR amplification, TP53 mutations, and 1p/19q co-deletion, and the prognostic significance of these, were investigated for the gliomas. MGMT promoter hypermethylation was identified in 37.8% of gliomas, but was not present in non-glial tumors, with the excepti...

S100B protein as a possible participant in the brain metastasis of NSCLC

Medical Oncology — Fri, 27 Jan 2012 17:56:11 +0100

Abstract Brain metastasis is a frequent occurrence in lung cancer, especially non-small cell lung cancer (NSCLC), the prognosis for NSCLC with brain metastasis is very poor. Our previous study found high S100B expression in the brain-specific metastatic NSCLC line PC14/B, suggested S100B is closely correlated with brain metastasis in NSCLC. However, the details have not yet been revealed. The aim of this study was to investigate the correlation between S100B and brain metastasis in NSCLC and to study the effects of S100B on non-brain metastatic NSCLC line PC14. We investigated serum S100B levels in 30 newly diagnosed NSCLC patients (15 with brain metastasis and 15 without brain metastasis) using enzyme-linked immunosorbent assay. Results showed that serum S100B levels were ...

Hematogenous extraneural metastasis of the germinomatous component of a pineal mixed germ cell tumor

Brain Tumor Pathology — Fri, 27 Jan 2012 17:56:01 +0100

Abstract A 23-year-old man presented with a mass in the pineal region and obstructive hydrocephalus. A neuroendoscopic biopsy for the lesion, ventriculoperitoneal (VP) shunting, and focal irradiation were conducted as initial treatment. Histological diagnosis of the biopsy specimen was germinoma. He underwent further irradiation and two tumor resections. Histological diagnosis was mature teratoma without a germinomatous component. After serial treatments, the intracranial lesion was controlled. However, 14 months after presentation, extraneural lesions were confirmed in the posterior mediastinum and retroperitoneal space. The biopsy specimen of the retroperitoneal space lesion was histologically diagnosed as germinoma. Although chemotherapy with cisplatin and etoposid...

The novel expression of Oct3/4 and Bmi1 in the root development of mouse molars

Cell and Tissue Research — Fri, 27 Jan 2012 17:54:29 +0100

This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig’s epithelial root sheath (HERS) cells expressed Bmi1 and cycli...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy

Journal of Molecular Medicine — Fri, 27 Jan 2012 17:53:02 +0100

In conclusion, srVSV is a promising platform for virotherapeutic approaches and also for VSV-based vector vaccines, combining improved safety with an increased coding capacity for therapeutic transgenes, potentially allowing for multipronged approaches. Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s00109-012-0863-6Authors Alexander Muik, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyCatherine Dold, Institute for Virology, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, AustriaYvonne Geiß, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyAndreas Volk, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyMarina Werbizki, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyUrsula Dietrich, Georg-Speyer-Haus, 60596 Frankfurt am Mai...

Oxygen Transport to Tissue XXXIII

Springer Biomedical Sciences titles — Fri, 27 Jan 2012 17:52:30 +0100

series:Advances in Experimental Medicine and BiologyBased on the 38th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Ascona, Switzerland in July 2010, this volume covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. It covers near infrared spectroscopy, brain oxygenation, tumor biology, angiogenesis ... (Source: Springer Biomedical Sciences titles)

Study: MRS may provide diagnostic, prognostic biomarker for brain tumors

Health Imaging News — Fri, 27 Jan 2012 13:14:01 +0100

A new magnetic resonance spectroscopy (MRS) technique may offer a method to detect and track a protein associated with a genetic mutation in brain tumor cancer cells. The method could inform diagnosis of glioma and provide prognostic information, according to a study published online Jan. 26 in Nature Medicine. (Source: Health Imaging News)

Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla) – no evidence of virus‐induced carcinogenesis

Journal of Medical Primatology — Fri, 27 Jan 2012 09:28:13 +0100

Conclusions Histopathologically and immunohistochemically, the tumour had striking similarities to human endocervicial adenocarcinomas of the common type. However, PCR analysis failed to identify herpes‐ or papillomaviral DNA in the tumor at the time of necropsy, thus leaving the question for cause of the disease open. (Source: Journal of Medical Primatology)

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases [Neurooncology]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion Prognostic factors for patients with brain metastases vary by diagnosis, and for each diagnosis, a robust separation into different GPA scores was discerned, implying considerable heterogeneity in outcome, even within a single tumor type. In summary, these indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases. (Source: Journal of Clinical Oncology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Bevacizumab and irinotecan in children with recurrent or refractory brain tumors: Toxicity and efficacy trends

Pediatric Blood and Cancer — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionBevacizumab‐related acute toxicity appears to be low in children, even in combination with irinotecan. Further prospective trials are required to confirm the hypothetical efficacy of bevacizumab and to assess the risk of long‐term toxicity especially in the youngest children. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Targeting the enhancer of zeste homologue 2 in medulloblastoma

International Journal of Cancer — Fri, 27 Jan 2012 05:00:00 +0100

AbstractEnhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer‐cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medulloblastoma. Inhibition of EZH2 by RNAi suppresses medulloblastoma tumor cell growth. We show that 3‐deazaneplanocin A, a chemical inhibitor of EZH2, can suppress medulloblastoma cell growth partially by inducing apoptosis. Suppression of EZH2 expression diminishes the ability of tumor cells...

The regulation of cysteine cathepsins and cystatins in human gliomas

International Journal of Cancer — Fri, 27 Jan 2012 05:00:00 +0100

AbstractCysteine cathepsins play an important role in shaping the highly infiltrative growth pattern of human gliomas. We have previously demonstrated that the activity of cysteine cathepsins is elevated in invasive GBM cells in vitro, in part due to attenuation of their endogenous inhibitors, the cystatins. To investigate this relationship in vivo, we established U87‐MG xenografts in NOD/SCID‐eGFP mice. Here, tumour growth correlated with an elevated enzymatic activity of CatB both in the tumour core and at the periphery, whereas CatS and CatL levels were higher at the xenograft edge compared to the core. Reversely, StefB expression was detected in the tumour core, but it was generally absent in the tumour periphery, suggesting that down‐regulation of this inhibitor correlates with ...

Efficacy of vincristine administered via convection-enhanced delivery in a rodent brainstem tumor model documented by bioluminescence imaging

Child's Nervous System — Thu, 26 Jan 2012 16:44:15 +0100

Conclusions VCR administered by CED was effective in reducing tumors and prolonging survival time. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00381-012-1690-3Authors Guifa Xi, Division of Pediatric Neurosurgery, Falk Brain Tumor Center, Children’s Memorial Hospital, Northwestern University, Feinberg School of Medicine, 2300 Children’s Plaza, 2430N Halsted St, Box # 28, Chicago, IL 60614, USAVeena Rajaram, Division of Anatomic Pathology, Children’s Memorial Hospital, 2300 Children’s Plaza, Box # 28, Chicago, IL 60614, USABabara Mania-Farnell, Department of Biological Sciences, Purdue University Calumet, 2200 169th Street, Hammond, IN 46323, USAChandra S. Mayanil, Department of Development Biology, Children’s Memorial Research Cent...

Are the psychological needs of adolescent survivors of pediatric cancer adequately identified and treated?

Psycho-Oncology — Thu, 26 Jan 2012 13:19:03 +0100

ConclusionsMany adolescent survivors of cancer experience psychological difficulties that are not adequately managed by current services, underscoring the need for long‐term surveillance. In addition to prescribing regular psychological evaluations, clinicians should closely monitor whether current support services appropriately meet survivors' needs, particularly for lower‐income survivors and those treated with cranial radiation therapy. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

[Image-guided radiation therapy : Paradigm change in radiation therapy.]

Der Radiologe — Thu, 26 Jan 2012 05:00:00 +0100

[Image-guided radiation therapy : Paradigm change in radiation therapy.] Radiologe. 2012 Jan 26; Authors: Wenz F, Belka C, Reiser M, Schönberg SO Abstract CLINICAL ISSUE: The introduction of image-guided radiotherapy (IGRT) has changed the workflow in radiation oncology more dramatically than any other innovation in the last decades. STANDARD TREATMENT: Imaging for treatment planning before the initiation of the radiotherapy series does not take alterations in patient anatomy and organ movement into account. TREATMENT INNOVATIONS: The principle of IGRT is the temporal and spatial connection of imaging in the treatment position immediately before radiation treatment. DIAGNOSTIC ASSE...

Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)‐MRI estimates of cerebral blood volume (CBV) in human gliomas

Journal of Magnetic Resonance Imaging — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion:The results suggest Gaussian normalization of leakage‐corrected CBV maps may be the best choice for image intensity correction for use in large‐scale, multicenter clinical trials where MR scanners and protocols vary widely due to ease of implementation, lowest variability, and highest tumor to normal tissue contrast. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)

Is T2* Enough to Assess Oxygenation? Quantitative Blood Oxygen Level-Dependent Analysis in Brain Tumor [Experimental Studies]

Radiology — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion: Additional measurements, such as BVf, T2, and B0, are needed to obtain reliable information on oxygenation with BOLD MR imaging. The proposed quantitative BOLD approach, which includes these measurements, appears to be a promising tool with which to map tumor oxygenation. © RSNA, 2011 (Source: Radiology)

Diagnostic brain tumor test could revolutionize care of patients

EurekAlert! - Medicine and Health — Thu, 26 Jan 2012 05:00:00 +0100

(UT Southwestern Medical Center) Researchers have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy. (Source: EurekAlert! - Medicine and Health)

Oncogene status predicts patterns of metastatic spread in treatment‐naive nonsmall cell lung cancer

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS:The results support the hypothesis that the dominant molecular oncogenes in NSCLC are associated with different biological behaviors manifesting as distinct patterns of metastatic spread at the time of diagnosis. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Prognostic significance of MRP5 immunohistochemical expression in glioblastoma

Cancer Chemotherapy and Pharmacology — Wed, 25 Jan 2012 18:14:31 +0100

Conclusion The present results imply that MRP5 index may hold a prognostic role in patients with GBM. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00280-012-1832-zAuthors George A. Alexiou, Department of Neurosurgery, University Hospital of Ioannina, Ioannina, GreeceAnna Goussia, Department of Pathology, University Hospital of Ioannina, Ioannina, GreeceSpyridon Voulgaris, Department of Neurosurgery, University Hospital of Ioannina, Ioannina, GreeceAndreas D. Fotopoulos, Department of Nuclear Medicine, University Hospital of Ioannina, Ioannina, GreeceGeorge Fotakopoulos, Department of Neurosurgery, University Hospital of Ioannina, Ioannina, GreeceAntigoni Ntoulia, Department of Pathology, University Hospital of Ioannina, Ioannina, GreeceA...

Intracranial Masson tumor: case report and literature review

Journal of Neuro-Oncology — Wed, 25 Jan 2012 18:04:09 +0100

We report a third case of a neonate who presented with the appearance of a metastatic brain tumor involving the orbit, sella, and cerebellum that was ultimately proven to be IPEH. A thorough literature review of IPEH is presented and we discuss this clinical entity and its management. Content Type Journal ArticleCategory Case ReportPages 1-7DOI 10.1007/s11060-012-0799-2Authors Chie-Schin Shih, Section of Pediatric Hematology/Oncology, Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 4340, Indianapolis, IN 46202, USARichard Burgett, Department of Ophthalmology, Indiana University, Indianapolis and Midwest Eye Institute, 200 West 103rd Street, Indianapolis, IN 46290, USAJose Bonnin, Department of Pathology and Laboratory Medicine, India...

Potential New Pathway Can Overcome Glioblastoma Resistance

Health News from Medical News Today — Wed, 25 Jan 2012 17:00:00 +0100

Glioblastoma is the most prevalent and most aggressive malignant brain tumor in humans, and is one of the most resistant to current treatments. Individuals with the disease typically survive around 15 months. Earlier research concentrated on activating the (apoptosis) cell death pathway through therapeutic agents like tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Most of these experiments were however impeded by resistance. Chunhai "Charlie" Hao, M.D., Ph.D... (Source: Health News from Medical News Today)

Possible New Pathway Can Overcome Glioblastoma Resistance

Health News from Medical News Today — Wed, 25 Jan 2012 09:00:00 +0100

Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months. Previous research has focused on the activation of the apoptosis, or cell death, pathway using therapeutic agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); however, the vast majority of these experiments have been stymied by resistance... (Source: Health News from Medical News Today)

New Way Discovered To Image Brain Tumors And Predict Recurrence

Health News from Medical News Today — Wed, 25 Jan 2012 08:00:00 +0100

After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival - depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires aggressive treatment... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Assessing advanced cancer pain in older adults with dementia at the end‐of‐life

Journal of Advanced Nursing — Wed, 25 Jan 2012 05:00:00 +0100

Conclusion. Because people with worsening Alzheimer’s disease have fewer pain behaviours, assessing pain using behavioural indicators can be a challenge. Improving methods to assess for pain in people with Alzheimer’s disease is of critical public health importance. Moreover, future studies are urgently needed to further examine the sensory, emotional, and behavioural responses to pain in people with Alzheimer’s disease. (Source: Journal of Advanced Nursing)

Trans-Lamina Terminalis Approach to Third Ventricle using Supraorbital Craniotomy: Technique Description and Literature Review for Outcome Comparison with Anterior, Lateral and Trans-Sphenoidal Corridors

min - Minimally Invasive Neurosurgery — Wed, 25 Jan 2012 05:00:00 +0100

Minim Invasive Neurosurg 2011; 54: 236-242DOI: 10.1055/s-0031-1297996The trans-lamina terminalis approach has been described to remove third ventricular tumors. Various surgical corridors for this approach include anterior (via bifrontal craniotomy), anterolateral (via supra-orbital craniotomy), lateral (via pterional craniotomy) and trans-sphenoidal corridors. Supra-orbital craniotomy offers a minimally invasive access for resection of third ventricular tumors.The trans-lamina terminalis technique through a supra-orbital craniotomy is described. Also, a literature review of clinical outcome data was performed for the comparison of different surgical corridors (anterior, antero-lateral, lateral, and trans-sphenoidal).The operative steps and anatomic landmarks for supra-orbital craniotomy a...

“Donut’s Shape” Radiosurgical Treatment Planning for Large Cystic Metastatic Brain Tumors

min - Minimally Invasive Neurosurgery — Wed, 25 Jan 2012 05:00:00 +0100

Minim Invasive Neurosurg 2011; 54: 286-289DOI: 10.1055/s-0031-1297987Radiosurgical management of large cystic metastatic brain tumors represents a significant challenge. Nevertheless, modified dose planning has shown beneficial results in such cases.“Donut’s shape” radiosurgical treatment planning is based on the chain-like application of multiple, small-sized isocenters for selective coverage of the contrast-enhancing tumor capsule and minimal irradiation of the central cystic area. Such an approach was used for the management of large cystic intracranial metastases, which were not accompanied by a significant mass effect and did not require immediate volume reduction. Treatment was done using Leksell Gamma Knife model C with automatic positioning system. The majority of treated les...

Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France.

Infection, Genetics and Evolution — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Vittecoq M, Elguero E, Lafferty K, Roche B, Brodeur J, Gauthier-Clerc M, Missé D, Thomas F Abstract The incidence of adult brain cancer was shown to be higher in countries where the parasite Toxoplasma gondii is common, suggesting that this brain protozoan could potentially increase the risk of tumor formation. Using countries as replicates has, however, several potential confounding factors, particularly because detection rates vary with country wealth. Using an independent dataset entirely within France, we further establish the significance of the association between T. gondii and brain cancer and find additional demographic resolution. In adult age classes 55years and older, regional mortality rates due to brain cancer correlated positively with the local seroprevalen...

Major Annoucement on Kidney Cancer Vaccine

Kidney Cancer Association — Tue, 24 Jan 2012 22:27:31 +0100

Roswell Park Launches Landmark Immunotherapy Vaccine Trial [Read More] The ability to stretch out the attack for a long-term, durable response suggests that the vaccine may be effective in preventing disease recurrence. The new NY-ESO-1 dendritic cell vaccine is expected to show great promise in patients with bladder, brain, breast, esophageal, gastrointestinal, hepatocellular, kidney, lung, melanoma, ovarian, prostate, sarcoma and uterine tumors. 01/24/2012 (Source: Kidney Cancer Association)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells

Journal of Clinical Investigation — Tue, 24 Jan 2012 19:12:02 +0100

Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. Neural derivatives of human embryonic stem cells (hESCs) are currently being used for cell therapy in 3 clinical trials. However, hESCs are prone to genomic instability, which could limit their clinical utility. Here, we report that neural differentiation of hESCs systematically produced a neural stem cell population that could be propagated for more than 50 passages without entering senescence; this was true for all 6 hESC lines tested. The apparent spontaneous loss of evolution toward normal senescence of somatic cells was associated with a jumping translocation of chromosome 1q. This chromosomal defect has previously been associated with hematologic malignancies and pediatric brain tumors with poor...

Stem cell therapy 'safe for eye condition'

NHS News Feed — Tue, 24 Jan 2012 17:55:00 +0100

Conclusion This was a small clinical trial that assessed the safety of using stem cell technology to treat one person with Stargardt’s macular dystrophy and one person with dry age-related macular degeneration. Specifically, it looked at the use of retinal cells that had been made from human embryonic stem cells. The primary focus of this research was to see whether this procedure would be safe, not whether it was effective. The researchers found that neither of the patients had problems with abnormal cell growth, tumour formation, graft rejection or any other pathological reaction or safety issues, all of which are potential problems in this type of treatment. The researchers followed the patients over four months but say that further follow-up is needed to observe the long-term effec...

Small Vessel Cerebrovascular Disease: The Past, Present, and Future

Journal of Cancer Epidemiology — Tue, 24 Jan 2012 16:28:40 +0100

Brain infarction due to small vessel cerebrovascular disease (SVCD)—also known as small vessel infarct (SVI) or “lacunar” stroke—accounts for 20% to 25% of all ischemic strokes. Historically, SVIs have been associated with a favorable short-term prognosis. However, studies over the years have demonstrated that SVCD/SVI is perhaps a more complex and less benign phenomenon than generally presumed. The currently employed diagnostic and therapeutic strategies are based upon historical and contemporary perceptions of SVCD/SVI. What is discovered in the future will unmask the true countenance of SVCD/SVI and help furnish more accurate prognostication schemes and effective treatments for this condition. This paper is an overview of SVCD/SVI with respect to the disc...

Recent advances in the molecular understanding of glioblastoma

Journal of Neuro-Oncology — Tue, 24 Jan 2012 07:32:31 +0100

Abstract Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor’s resistance to current therapeutic approaches. Thus far, methylation of the O 6-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel “genome-wide” techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 (IDH1) and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. It provides the clinician with an up-to-date overview of current identified molecu...

Diffusion tensor imaging fiber tracking using navigated brain stimulation—a feasibility study

Acta Neurochirurgica — Tue, 24 Jan 2012 07:28:23 +0100

Conclusions Conventional DTI-FT showed significant differences between the two modalities, most likely because of the more specific definition of the seed region when DTI-FT is based on NBS. Moreover, NBS-aided DTI fiber tracking is user-independent and, therefore, a method for further standardization of DTI fiber tracking. Content Type Journal ArticleCategory Clinical ArticlePages 1-9DOI 10.1007/s00701-011-1255-3Authors Sandro M. Krieg, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyNiels H. Buchmann, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyJens Gempt, Department of Neurosurgery, Klinikum rechts der I...

MedWorm Sponsor Message: Find the best January Sales in the UK.

The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo

European Journal of Nuclear Medicine and Molecular Imaging — Tue, 24 Jan 2012 07:19:32 +0100

Conclusion The TSPO radioligand [18F]DPA-714 can be used for PET imaging of intracranial 9L glioma in different rat strains. This preclinical study demonstrates the feasibility of employing [18F]DPA-714 as an alternative radiotracer to image human glioma. Content Type Journal ArticleCategory Original ArticlePages 1-13DOI 10.1007/s00259-011-2041-4Authors Alexandra Winkeler, Inserm, U1023, Laboratoire d’Imagerie Moléculaire Expérimentale, Université Paris Sud, Orsay, FranceRaphael Boisgard, Inserm, U1023, Laboratoire d’Imagerie Moléculaire Expérimentale, Université Paris Sud, Orsay, FranceAli R. Awde, Inserm, U1023, Laboratoire d’Imagerie Moléculaire Expérimentale, Université Paris Sud, Orsay, FranceAlbertine Dubois, Inserm, U1023, Laboratoire d’Imager...

p53-dependent pathways in neurite outgrowth and axonal regeneration

Cell and Tissue Research — Tue, 24 Jan 2012 07:15:53 +0100

Abstract The tumor suppressor p53 is a multifunctional sensor of a number of cellular signals and pathways essential for cell biology, including DNA damage, cell cycle regulation, apoptosis, angiogenesis and cell metabolism. In the last few years, a novel role for p53 in neurobiology has emerged, which includes a role in the regulation of neurite outgrowth and axonal regeneration. p53 integrates a number of extracellular signals that involve neurotrophins and axon guidance cues to modulate the cytoskeletal response associated with neurite outgrowth at both the transcriptional and post-translational level. Here, we review our current knowledge of this topic and speculate about future research directions that involve p53 and related molecular pathways and that might advance ...

Risk of second cancers in Waldenstrom macroglobulinemia

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: WM patients are at higher risk of second cancers as compared with the general population. The sample size does not allow firm conclusions about the effect of therapy on the development of second cancers. (Source: Annals of Oncology)

Intracranial hemorrhage in patients with cancer treated with bevacizumab: the Memorial Sloan-Kettering experience

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: ICH with bevacizumab treatment in this population is rare and does not appear to increase its frequency over the baseline rate of ICH in a comparable population. Most bevacizumab-related ICH occurs into central nervous system tumors but spontaneous hemorrhages were seen. (Source: Annals of Oncology)

Dietary cholesterol intake and cancer

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: Our findings add to the evidence that high cholesterol intake is linked to increased risk of various cancers. A diet low in cholesterol may play a role in the prevention of several cancers. (Source: Annals of Oncology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Metastasis: A new protector?

Nature Reviews Cancer — Tue, 24 Jan 2012 05:00:00 +0100

Nature Reviews Cancer 12, 81 (2012). doi:10.1038/nrc3225 Author: Nicola McCarthy Pigment epithelium-derived factor (PEDF) is a cytokine that is expressed in human primary breast cancers but not in breast cancer brain metastases. Patricia Steeg and colleagues now show that human and mouse breast cancer cells expressing PEDF cannot establish large brain metastases. In addition, the (Source: Nature Reviews Cancer)

Non-Cytotoxic Radiosensitizers in Brain Radiotherapy: Journey till the First Decade of this Millennium.

Current Cancer Drug Targets — Tue, 24 Jan 2012 05:00:00 +0100

This article reviews the evolution of evidence with use of non-cytotoxic radiosensitizers in brain radiotherapy and their status at the end of the first decade of this millennium. Considering, the era of development and mechanism of action, these agents are classified as first, second and third-generation non-cytotoxic radiosensitizers. The last millennium involved elaboration of first-generation compounds including halogenated pyrimidines, hypoxic cell sensitizers (e.g. imidazoles) and glycolytic inhibitors (e.g. lonidamine). The first decade of this millennium has highlighted redox modulators like motexafin gadolinium and newer hypoxic cell sensitizers like efaproxiral, which have shown promise. However, phase III trials and meta-analyses have not identified a clear winner though the sec...

Targeted Therapy for Brain Tumours: Role of PARP Inhibitors.

Current Cancer Drug Targets — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Leonetti C, Biroccio A, Graziani G, Tentori L Abstract The prognosis of malignant glioma and metastatic brain tumours is still extremely poor, despite recent advances in therapeutic strategies with molecular-targeted agents. Poly(ADP-ribose) polymerase (PARP) inhibitors are a promising, novel class of anticancer drugs to be used either as single agents or in combination with chemotherapy and radiotherapy. PARP-1 and PARP-2 are the only PARP proteins that bind to DNA single strand breaks (SSBs), facilitating the repair process by the base excision repair. For this reason, PARPs have been extensively investigated as targets of novel drugs that may be used to enhance the antitumour activity of SSBs inducing agents, such as the methylating compound temozolomide, which is the d...

New Target Therapies for Brain Metastases from Breast Cancer.

Current Cancer Drug Targets — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Metro G, Fabi A Abstract Central nervous system (CNS) metastases from breast cancer (BC) represent an important cause of disease-related morbidity and mortality. For BC patients who develop CNS metastases, local control measures (both surgery and radiation) are essentially palliative and usually poorly effective, with systemic therapies often failing to achieve optimal control mainly due to the presence of the blood-brain barrier which hampers adequate penetration of therapeutic agents into the brain. However, recent evidence suggests that the status of the human epidermal growth factor receptor-2 (HER2) strongly influences the incidence of CNS metastases and the survival of BC patients from the time of development of CNS metastases, with HER2-positive (HER2+) patients gen...

Nanotech Revolution for the Anti-Cancer Drug Delivery through Blood-Brain-Barrier.

Current Cancer Drug Targets — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Caraglia M, De Rosa G, Salzano G, Santini D, Lamberti M, Sperlongano P, Lombardi A, Abbruzzese A, Addeo R Abstract Nanotechnology-based drug delivery was born as a chance for pharmaceutical weapons to be delivered in the body sites where drug action is required. Specifically, the incorporation of anti-cancer agents in nanodevices of 100-300 nm allows their delivery in tissues that have a fenestrated vasculature and a reduced lymphatic drainage. These two features are typical of neoplastic tissues and, therefore, allow the accumulation of nanostructured devices in tumours. An important issue of anti-cancer pharmacological strategies is the overcoming of anatomical barriers such as the blood-brain-barrier (BBB) that protects brain from toxicological injuries but, at the same...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Target therapy in brain tumours and metastases.

Current Cancer Drug Targets — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Caraglia M, Addeo R PMID: 22268383 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)

The Malignant Divorce: Has NASA Gone Postal?

Psychology Today Personality Center — Tue, 24 Jan 2012 03:01:06 +0100

Heaven has no rage like love betrayed read more (Source: Psychology Today Personality Center)

1/27 Systemic Therapy for Brain Metastases from Breast Cancer

DF/HCC: Latest News — Mon, 23 Jan 2012 15:39:00 +0100

(Source: DF/HCC: Latest News)

Team Finds New Way to Image Brain Tumors and Predict Recurrence

UCSF Medical Center — Mon, 23 Jan 2012 08:00:00 +0100

After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival, depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires aggressive treatment. (Source: UCSF Medical Center)

Team finds new way to image brain tumors and predict recurrence

EurekAlert! - Medicine and Health — Mon, 23 Jan 2012 05:00:00 +0100

(University of California - San Francisco) After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival -- depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires aggressive treatment. (Source: EurekAlert! - Medicine and Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Posterior Reversible Encephalopathy Syndrome

Journal of Intensive Care Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Posterior reversible encephalopathy syndrome (PRES) is characterized by headache, altered mental status, visual disturbances, and seizures. Radiological features typically include edema of the posterior cerebral regions, especially of the parietooccipital lobes. Atypical imaging features, such as involvement of anterior cerebral regions, deep white matter, and the brain stem are also frequently seen. Vasoconstriction is common in vascular imaging. Different conditions have been associated with PRES, but toxemia of pregnancy, solid organ or bone marrow transplantation, immunosuppressive treatment, cancer chemotherapy, autoimmune diseases, and hypertension are most commonly described. The pathophysiology of PRES is unclear and different hypotheses are being discussed. Posterior reversible en...

Tissue-Specific Regulation of Genes by Estrogen Receptors

Seminars in Reproductive Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Semin Reprod Med 2012; 30: 14-22DOI: 10.1055/s-0031-1299593Estrogens are frequently used in reproductive medicine. The Women’s Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the benefits. The estrogens in MHT, however, were introduced prior to our understanding of the mechanism of action of estrogens. Estrogen signaling is highly complex, involving various DNA regulatory elements to which estrogen receptors bind. Numerous transcription factors and co-regulatory proteins modify chromatin structure to further regulate gene transcription. With a greater understanding of estrogen action, the major problem with the current estrogens in MHT appears to be that they are nonselective. This produces beneficial effects in bone, brain, and adipose tissue but ...

Therapy can add years to certain brain tumor patients' lives

USATODAY.com Health — Sun, 22 Jan 2012 23:25:32 +0100

In a victory for personalized medicine, new treatment doubles survival for brain tumor patients with genetic mutation. (Source: USATODAY.com Health)

In Patients With Rare Brain Tumor, Abnormal Chromosome Indicator Of Treatment And Outcome

Health News from Medical News Today — Sun, 22 Jan 2012 08:00:00 +0100

A recent analysis of clinical trial results performed by the Radiation Therapy Oncology Group (RTOG) demonstrate that a chromosomal abnormality - specifically, the absence (co-deletion) of chromosomes 1p and 19q - have definitive prognostic and predictive value for managing the treatment of adult patients with pure and mixed anaplastic oligodendrogliomas... (Source: Health News from Medical News Today)

Charlie Williams shares his battle with cancer to help others

the Mail online | Health — Sat, 21 Jan 2012 13:24:21 +0100

Charlie Williams, from Boxford in Suffolk, was just five when he was diagnosed with medulloblastoma. The killer brain tumour strikes down about 50 children in the UK a year. (Source: the Mail online | Health)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Staging and imaging of small cell lung cancer.

Cancer Imaging — Sat, 21 Jan 2012 05:24:04 +0100

Authors: Kalemkerian GP Abstract Small cell lung cancer (SCLC) has been primarily classified as limited or extensive, with limited stage confined to the primary tumor and regional lymph nodes. In the future, the TNM staging system should be integrated into the classification of SCLC. The appropriate staging work-up for patients with SCLC has traditionally included contrast-enhanced computed tomography (CT) scans of the chest and abdomen, bone scan, and magnetic resonance imaging or CT scan of the brain. Recent data suggest that positron emission tomography can improve both staging accuracy and treatment planning in patients with SCLC. Treatment for limited-stage SCLC consists of chemotherapy plus radiotherapy, and such therapy can cure 20-25% of patients. Extensive-stage SCLC is in...

Reduced growth hormone secretion after cranial irradiation contributes to neurocognitive dysfunction.

Growth Hormone and IGF Research — Sat, 21 Jan 2012 05:00:00 +0100

In this study only 21% (4/19) of the patients who received fractionated radiotherapy for a non-endocrine brain tumor were diagnosed with GHD. GHD in these patients was associated with impaired interference control, attentional shifting, and visual long-term memory. The results for interference control and attentional shifting suggest an additional effect of the radiation history. PMID: 22269954 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research)

RTOG reveals “practice-changing” marker for brain tumor treatment

Health Imaging News — Fri, 20 Jan 2012 10:12:47 +0100

An analysis of clinical trial results performed by the Radiation Therapy Oncology Group (RTOG) demonstrated that a chromosomal abnormality has definitive prognostic and predictive value for managing the treatment of adult patients with pure and mixed anaplastic oligodendrogliomas. "These are exciting and practice-changing results," said Walter J. Curran, Jr., MD, RTOG group chair and executive director of the Winship Cancer Institute of Emory University in Atlanta, in a statement. (Source: Health Imaging News)

Aquaporins in clinical medicine.

Annual Review of Medicine — Fri, 20 Jan 2012 09:00:36 +0100

Authors: Verkman AS Abstract The aquaporins are a family of membrane water channels, some of which also transport glycerol. They are involved in a wide range of physiological functions (including water/salt homeostasis, exocrine fluid secretion, and epidermal hydration) and human diseases (including glaucoma, cancer, epilepsy, and obesity). At the cellular level, aquaporin-mediated osmotic water transport across cell plasma membranes facilitates transepithelial fluid transport, cell migration, and neuroexcitation; aquaporin-mediated glycerol transport regulates cell proliferation, adipocyte metabolism, and epidermal water retention. Genetic diseases caused by loss-of-function mutations in aquaporins include nephrogenic diabetes insipidus and congenital cataracts. The neuroinflammat...

New Method Pinpoints Important Gene-Regulation Proteins

Health News from Medical News Today — Fri, 20 Jan 2012 09:00:00 +0100

A novel technique has been developed and demonstrated at Penn State University to map the proteins that read and regulate chromosomes - the string-like structures inside cells that carry genes. The specific order in which these proteins attach DNA-containing nucleosomes along the chromosome determines whether a brain cell, a liver cell, or a cancer cell is formed. Until now, it has been exceedingly difficult to determine exactly where such proteins bind to the chromosome, and therefore how they work... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Oxygen Starvation Reverses Radiation-Induced Damage To Brain Tissue In Mouse Model

Health News from Medical News Today — Fri, 20 Jan 2012 08:00:00 +0100

Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation. The results are reported in the online journal PLoS ONE. The researchers, led by William Sonntag of University of Oklahoma, exposed the mice to a clinically relevant regimen of radiation, which caused progressive deterioration of spatial learning starting about two months post-radiation... (Source: Health News from Medical News Today)

Novel Mechanism Of Glioblastoma Development Revealed

Health News from Medical News Today — Fri, 20 Jan 2012 08:00:00 +0100

Most research on glioblastoma development, a complicated tumor of the brain with a poor prognosis, has focused on the gene transcription level, but scientists suggest that post-transcriptional regulation could be equally or even more important. In a recent report in Molecular Cancer Research, a journal of the American Association for Cancer Research, scientists led by Luiz O. F. Penalva, Ph.D... (Source: Health News from Medical News Today)

miR-200b regulates cell migration via Zeb family during mouse palate development

Histochemistry and Cell Biology — Fri, 20 Jan 2012 07:07:57 +0100

Abstract Palate development requires coordinating proper cellular and molecular events in palatogenesis, including the epithelial–mesenchymal transition (EMT), apoptosis, cell proliferation, and cell migration. Zeb1 and Zeb2 regulate epithelial cadherin (E-cadherin) and EMT during organogenesis. While microRNA 200b (miR-200b) is known to be a negative regulator of Zeb1 and Zeb2 in cancer progression, its regulatory effects on Zeb1 and Zeb2 in palatogenesis have not yet been clarified. The aim of this study is to investigate the relationship between the regulators of palatal development, specifically, miR-200b and the Zeb family. Expression of both Zeb1 and Zeb2 was detected in the mesenchyme of the mouse palate, while miR-200b was expressed in the medial edge epithelium. Aft...

Long-Term Outcome of Patients With Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency.

The American Journal of the Medical Sciences — Fri, 20 Jan 2012 05:00:00 +0100

CONCLUSION: CAH patients have a number of issues due to the disease or its treatment. Regular follow-up, early lifestyle interventions, bone health assessment, testicular ultrasound and psychological management are needed. PMID: 22270393 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

Brain tumor formation better understood

Health News - UPI.com — Thu, 19 Jan 2012 22:56:04 +0100

SAN ANTONIO, Jan. 19 (UPI) -- The connection between two RNA-binding proteins may affect glioblastoma, the brain cancer that killed the late Sen. Edward Kennedy, U.S. researchers say. (Source: Health News - UPI.com)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Genetic abnormality predicts benefit from treatment for a rare brain tumor

National Institutes of Health (NIH) News Releases — Thu, 19 Jan 2012 21:06:00 +0100

A clinical trial has shown that addition of chemotherapy to radiation therapy leads to a near doubling of median survival time in patients with a form of brain tumor (oligodendroglioma) that carries a chromosomal abnormality called the 1p19q co-deletion. (Source: National Institutes of Health (NIH) News Releases)

Key To Stopping Growth And Migration Of Brain Cancer Cells Is Cell Signaling

Health News from Medical News Today — Thu, 19 Jan 2012 09:00:00 +0100

Brain cancer is hard to treat: it's not only strong enough to resist most chemotherapies, but also nimble enough to migrate away from radiation or surgery to regrow elsewhere. New research at the University of Colorado Cancer Center shows how to stop both. Specifically, cells signal themselves to survive, grow, reproduce, and migrate. Two years ago(1), researchers at the CU Cancer Center showed that turning off a family of signals made brain cancer cells less robust - it sensitized these previously resistant cells to chemotherapy... (Source: Health News from Medical News Today)

Rigged to explode?

EurekAlert! - Medicine and Health — Thu, 19 Jan 2012 05:00:00 +0100

(European Molecular Biology Laboratory) An inherited mutation is likely the link between exploding chromosomes and the pediatric brain tumor which is the second most common cause of childhood mortality in developed countries, scientists at EMBL, DKFZ and the University Hospital, all in Heidelberg, Germany, have discovered. (Source: EurekAlert! - Medicine and Health)

Abnormal chromosome indicator of treatment and outcome in patients with rare brain tumor

EurekAlert! - Cancer — Thu, 19 Jan 2012 05:00:00 +0100

(American College of Radiology) A Radiation Therapy Oncology Group trial shows that, in adults with an oligodendroglioma brain tumor, a chromosomal abnormality is associated with a near-doubling of median survival time and better prognosis when patients are treated with combined chemotherapy and radiation therapy compared to radiation therapy alone. (Source: EurekAlert! - Cancer)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Cellular phones: To talk or not to talk

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

This article gives a summary view of the possible effects related to cellular phone use. It further discusses if we need to observe precautions while using these devices. (Source: Journal of Cancer Research and Therapeutics)

Overexpression of potassium channel ether à go-go in human osteosarcoma.

Neoplasma — Thu, 19 Jan 2012 04:30:02 +0100

Authors: Wu J, Wu X, Lian K, Lin B, Guo L, Ding Z Abstract Human ether à go-go (hEAG) potassium channels are primarily expressed in brain but also frequently overexpressed in solid tumors, which could indicate their potential value for cancer diagnosis and therapy. hEAG1, one member of the hEAG subfamily, has been shown to play a role in neoplastic process. Here we report the expression of hEAG1 in human osteosarcoma detected by a new polyclonal antibody. The full-length hEAG1 cDNA was cloned from human osteosarcoma cell line MG63 by RT-PCR and expressed in Escherichia coli as His tagged protein. The 6His-hEAG1F protein was purified by nickel agarose and used as the antigen to immunize rabbits following standard protocols. The obtained antiserum could detect hEAG1 exogenously ...

Important gene-regulation proteins pinpointed by new method

ScienceDaily Headlines — Wed, 18 Jan 2012 18:23:23 +0100

A novel technique precisely pinpoints the location of proteins that read and regulate chromosomes. The order of these proteins determines whether a brain cell, a liver cell, or a cancer cell is formed. Until now, it has been exceedingly difficult to determine exactly where such proteins bind to the chromosome, and therefore how they work. The new technique has the potential to take high-resolution snapshots of proteins as they regulate or miss-regulate an entire genome. (Source: ScienceDaily Headlines)

Adhesion of Porphyromonas gingivalis and Biofilm Formation on Different Types of Orthodontic Brackets

Journal of Cancer Epidemiology — Wed, 18 Jan 2012 17:01:46 +0100

Conclusions. The salivary pellicle seems to facilitate the adhesion of P. gingivalis and biofilm formation on orthodontic brackets, while the material comprising the brackets does not significantly impact on the number of bacteria. (Source: Journal of Cancer Epidemiology)

The Impact of MicroRNAs on Brain Aging and Neurodegeneration

Journal of Cancer Epidemiology — Wed, 18 Jan 2012 17:01:46 +0100

The molecular instructions that govern gene expression regulation are encoded in the genome and ultimately determine the morphology and functional specifications of the human brain. As a consequence, changes in gene expression levels might be directly related to the functional decline associated with brain aging. Small noncoding RNAs, including miRNAs, comprise a group of regulatory molecules that modulate the expression of hundred of genes which play important roles in brain metabolism. Recent comparative studies in humans and nonhuman primates revealed that miRNAs regulate multiple pathways and interconnected signaling cascades that are the basis for the cognitive decline and neurodegenerative disorders during aging. Identifying the roles of miRNAs and their target genes in model organis...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Scientists uncover novel mechanism of glioblastoma development

EurekAlert! - Medicine and Health — Wed, 18 Jan 2012 05:00:00 +0100

(American Association for Cancer Research) Most research on glioblastoma development, a complicated tumor of the brain with a poor prognosis, has focused on the gene transcription level, but scientists suggest that post-transcriptional regulation could be equally or even more important. (Source: EurekAlert! - Medicine and Health)

Important gene-regulation proteins pinpointed by new method

EurekAlert! - Medicine and Health — Wed, 18 Jan 2012 05:00:00 +0100

(Penn State) A novel technique precisely pinpoints the location of proteins that read and regulate chromosomes. The order of these proteins determines whether a brain cell, a liver cell, or a cancer cell is formed. Until now, it has been exceedingly difficult to determine exactly where such proteins bind to the chromosome, and therefore how they work. The new technique has the potential to take high-resolution snapshots of proteins as they regulate or miss-regulate an entire genome. (Source: EurekAlert! - Medicine and Health)

Radiation-induced damage to brain tissue reversed by oxygen starvation in mice

EurekAlert! - Cancer — Wed, 18 Jan 2012 05:00:00 +0100

(Public Library of Science) Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation (Source: EurekAlert! - Cancer)

Rapid Radiographic and Clinical Improvement After Treatment of a MET-Amplified Recurrent Glioblastoma With a Mesenchymal-Epithelial Transition Inhibitor [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

Longitudinal Assessment of Chemotherapy-Induced Structural Changes in Cerebral White Matter and Its Correlation With Impaired Cognitive Functioning [Breast Cancer]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion We report evidence of longitudinal changes in cognitive functioning and cerebral WM integrity after chemotherapy as well as an association between both. (Source: Journal of Clinical Oncology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Safety and Efficacy of Combination Immunotherapy With Interferon Alfa-2b and Tremelimumab in Patients With Stage IV Melanoma [Melanoma]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion HDI can be administered combined with tremelimumab with acceptable toxicity and promising durable antitumor efficacy that warrant further testing in a randomized trial. (Source: Journal of Clinical Oncology)

Effect of Oxytocin on Neuroblastoma Cell Viability and Growth.

Cellular and Molecular Neurobiology — Wed, 18 Jan 2012 05:00:00 +0100

In conclusion, oxytocin increases growth and viability of neuroblastoma and glioblastoma cells without activation of neurotrophic factors. Oxytocin does not have protective effect in oxidative stress; however, it might be important for neuroprotection to dopaminergic neurons. Its proliferative effect might be important in native cell life, euplastic processes, and tumor progression. PMID: 22252786 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Neurobiology)

The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: Increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased β-amyloid(1-40) peptide and TNF-α contents, and susceptibility of mitochondria to an in vitro H(2)O(2) challenge.

Brain Research Bulletin — Wed, 18 Jan 2012 05:00:00 +0100

Authors: de Oliveira MR, da Rocha RF, Pasquali MA, Moreira JC Abstract Even though vitamin A has been viewed as an antioxidant molecule, recent findings demonstrate that such vitamin elicits pro-oxidant effects in vivo. Moreover, vitamin A supplements utilization may increase mortality rates among healthy subjects. However, the mechanism by which vitamin A elicits such effects remains to be better analyzed. In this regard, we investigated here the consequences of vitamin A supplementation at 500, 1000, or 2500IU/kgday(-1) for 3 months on adult rat substantia nigra and striatum total and mitochondrial redox state (both oxidative and nitrosative stress markers), electron transfer chain activity, monoamine oxidase (MAO) enzyme activity, endoplasmic reticulum stress marker (BiP), α- a...

Dose to craniofacial region through portal imaging of pediatric brain tumors.

Journal of Applied Clinical Medical Physics — Tue, 17 Jan 2012 11:30:03 +0100

Authors: Hitchen CJ, Osa EO, Dewyngaert K, Chang J, Narayana A Abstract The purpose of this study was to determine dose to the planning target volume (PTV) and organs at risk (OARs) from portal imaging (PI) of the craniofacial region in pediatric brain tumor patients treated with intensity-modulated radiation therapy (IMRT). Twenty pediatric brain tumor patients were retrospectively studied. Each received portal imaging of treatment fields and orthogonal setup fields in the craniofacial region. The number of PI and monitor units used for PI were documented for each patient. Dose distributions and dose-volume histograms were generated to quantify the maximum, minimum, and mean dose to the PTV, and the mean dose to OARs through PI acquisition. The doses resulting from PI are reported...

Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: a case report

Journal of Neuro-Oncology — Tue, 17 Jan 2012 07:19:32 +0100

This report describes the first known experience of patients with RPCNSL treated with bendamustine. Therapy was well-tolerated and best response was noted as stable disease after eight cycles of bendamustine followed by a subsequent local systemic recurrence found at five months follow-up. CNS involvement in this patient remained stable 20 + months post-bendamustine treatment. Based on our observations, further neuropharmacokinetic and efficacy studies with bendamustine may be warranted in this patient population. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s11060-011-0788-xAuthors Jaclyn J. Renfrow, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAAlisha DeTroye, Department of Internal Medicine, Section on Hematology and Oncology, C...

MedWorm Sponsor Message: Find the best January Sales in the UK.

The “go or grow” potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress

Acta Neuropathologica — Tue, 17 Jan 2012 07:11:19 +0100

Abstract Glioblastoma (GBM), the most common malignant brain tumor, is among the most lethal neoplasms, with a median survival of approximately 1 year. Prognosis is poor since GBMs possess a strong migratory and highly invasive potential, making complete surgical resection impossible. Reduced expression of carboxypeptidase E (CPE), a neuropeptide-processing enzyme, in a cell death-resistant glioma cell line and lower CPE expression levels in the cohort of GBM samples of The Cancer Genome Atlas compared to normal brain control specimens prompted us to analyze the function of CPE as a putative tumor suppressor gene. In our samples, CPE was also reduced in GBM compared to normal brain with the strongest loss in cells surrounding hypoxic tumor areas as well as in most gli...

Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells

Child's Nervous System — Tue, 17 Jan 2012 07:08:49 +0100

Abstract Introduction CD133 (PROM1) is a potential marker for cancer stem cells (CSCs), including those found in brain tumors. Recently, medulloblastoma (MB)-derived CD133-positive cells were found to have CSC-like properties and were proposed to be important contributors to tumorigenicity, cancer progression, and chemoradioresistance. However, the biomolecular pathways and therapeutic targets specific to MB-derived CSCs remain unresolved. Materials and methods In the present study, we isolated CD133+ cells from MB cell lines and determined that they showed increased tumorigenicity, radioresistance, and higher expression of both embryonic stem cell-related and drug resistance-related genes compared to CD133− cells. Bioinformatics analysis suggested tha...

Temozolomide for Pediatric High-Grade Gliomas

Current Neurology and Neuroscience Reports — Tue, 17 Jan 2012 07:06:32 +0100

Content Type Journal ArticleCategory Clinical Trial ReportPages 1-3DOI 10.1007/s11910-012-0250-2Authors Roger J. Packer, Center for Neuroscience and Behavioral Medicine, Children’s National Medical Center, Gilbert Neurofibromatosis Institute, Brain Tumor Institute, 111 Michigan Avenue, NW, Washington, DC 20010, USA Journal Current Neurology and Neuroscience ReportsOnline ISSN 1534-6293Print ISSN 1528-4042 (Source: Current Neurology and Neuroscience Reports)

A call to researchers: The Cancer Genome Atlas

National Brain Tumor Society — Tue, 17 Jan 2012 06:00:00 +0100

TCGA is asking for researchers to help them collect low-grade glioma samples. (Source: National Brain Tumor Society)

Attention Researchers: Help TCGA With Low-Grade Gliomas

National Brain Tumor Society — Tue, 17 Jan 2012 06:00:00 +0100

TCGA is asking for researchers to help them collect low-grade glioma samples. (Source: National Brain Tumor Society)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Cell signaling key to stopping growth and migration of brain cancer cells

EurekAlert! - Medicine and Health — Tue, 17 Jan 2012 05:00:00 +0100

(University of Colorado Denver) Inhibition of cell signaling through the Mer receptor tyrosine kinase pathway shown to both sensitize glioblastoma cells to chemotherapy and decrease their ability to migrate to other, non-targeted areas of the brain. (Source: EurekAlert! - Medicine and Health)

Glial cells in (patho)physiology

Journal of Neurochemistry — Tue, 17 Jan 2012 05:00:00 +0100

AbstractNeuroglial cells define brain homeostasis and mount defense against pathological insults. Astroglia regulate neurogenesis and development of brain circuits. In the adult brain, astrocytes enter into intimate dynamic relationship with neurons, especially at synaptic sites where they functionally form the tripartite synapse. At these sites astrocytes regulate ion and neurotransmitter homeostasis, metabolically support neurons and monitor synaptic activity; one of the readouts of the latter manifests in astrocytic intracellular Ca2+ signals. This form of astrocytic excitability can lead to release of chemical transmitters via Ca2+‐dependent exocytosis. Once in the extracellular space, gliotransmitters can modulate synaptic plasticity and cause changes in behavior. Besides these phys...

Eosinophils in glioblastoma biology

Journal of Neuroinflammation — Tue, 17 Jan 2012 05:00:00 +0100

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The development of this malignant glial lesion involves a multi-faceted process that results in a loss of genetic or epigenetic gene control, un-regulated cell growth, and immune tolerance. Of interest, atopic diseases are characterized by a lack of immune tolerance and are inversely associated with glioma risk. One cell type that is an established effector cell in the pathobiology of atopic disease is the eosinophil. In response to various stimuli, the eosinophil is able to produce cytotoxic granules, neuromediators, and pro-inflammatory cytokines as well as pro-fibrotic and angiogenic factors involved in pathogen clearance and tissue remodeling and repair. These various biological properties reveal that the e...

The role of aquaporin 4 in the brain

Veterinary Clinical Pathology — Tue, 17 Jan 2012 05:00:00 +0100

Abstract:Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus. Water transport through AQP4 depends on concentration gradients across the membrane, but the rate of transport is determined by the capacity of astrocytes to up‐ and down‐regulate AQP4 numbers, their location within the membrane, and the overall permeability of the channel. Other functions of brain AQP4 involve potassium uptake and release by astrocytes, migration of glial cells, glial scarring, and astrocyte‐to‐astrocyte cell communication. AQP water channels are involved in forma...

Imaging Technology For Looking Inside Brain May Help Test New Brain Cancer Drugs

Health News from Medical News Today — Mon, 16 Jan 2012 20:00:00 +0100

Using imaging technology that reveals whether brain tumors have a particular genetic mutation known as IDH, a team of academic and pharmaceutical company researchers has developed a way to help doctors select the right treatment, and developers to make new drugs that target the mutation. The researchers, from MIT, Harvard University, Massachusetts General Hospital (MGH) and Agios Pharmaceuticals, write about their findings in the 11 January online issue of Science Translational Medicine. Some of the deadliest cancers are those that affect the brain... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy.

Herpes — Mon, 16 Jan 2012 05:00:00 +0100

Authors: Koo T, Choi IK, Kim M, Lee JS, Oh E, Kim J, Yun CO Abstract Intact p53 function is essential for responsiveness to cancer therapy. However, p53 activity is attenuated by the proto-oncoprotein Mdm2, the adenovirus protein E1B-55kD, and the p53 C-terminal domain. To confer resistance to Mdm2, E1B-55kD, and C-terminal negative regulation, we generated a p53 variant (p53VPΔ30) by deleting the N-terminal and C-terminal regions of wild-type (wt) p53 and inserting the transcriptional activation domain of herpes simplex virus VP16 protein. The oncolytic adenovirus vector Ad-mΔ19 expressing p53VPΔ30 (Ad-m19/p53VPΔ30) showed greater cytotoxicity than Ad-mΔ19 expressing wt p53 or other p53 variants in human cancer cell lines. We found that Ad-m∆19/p53VPΔ30 induced apopt...

Targeting EGFR for Treatment of Glioblastoma: Molecular Basis to Overcome Resistance.

Current Cancer Drug Targets — Mon, 16 Jan 2012 05:00:00 +0100

Authors: Taylor TE, Furnari FB, Cavenee WK Abstract Glioblastoma (glioblastoma multiforme; GBM; WHO Grade IV) accounts for the majority of primary malignant brain tumors in adults. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in GBM. A range of potential therapies that target EGFR or its mutant constitutively active form, ΔEGFR, including tyrosine kinase inhibitors (TKIs), monoclonal antibodies, vaccines, and RNA-based agents, are currently in development or in clinical trials for the treatment of GBM. Data from experimental studies evaluating these therapies have been very promising; however, their efficacy in the clinic has so far been limited by both upfront and acquired drug resistance. Thi...

Biomedicine: A Recipe for Brain Injury

Editors' Choice — Sun, 15 Jan 2012 06:42:28 +0100

Type 2 diabetes, hypertension, heart disease, stroke, osteoarthritis, cancer. In case the list of health issues associated with a poor diet and obesity is not daunting enough, new research has … [Read more] (Source: Editors' Choice)

Ad men use brain scanners to probe our emotional response

Guardian Unlimited Science — Sat, 14 Jan 2012 17:28:08 +0100

Neuromarketers are using MRI scanners and electrode caps to work out our hidden reactions to their advertsThe world's biggest companies have got a new way of convincing you to buy their products – by getting inside your head. Brands including Google, Facebook and ITV are turning to mind-reading technology to help them develop products and create adverts that people like.Traditionally, focus groups have been used to tell marketeers what they think of adverts. Unfortunately for advertisers, some people don't tell the truth.Faced with the prospect of consumers hiding their emotions – perhaps a middle-aged man reluctant to reveal that he shed a tear at a sentimental John Lewis Christmas advert – a new breed of "neuromarketer" has emerged, armed with medical technology to probe consumers'...

Cancer drug gets stronger label warning

Reuters: Health — Fri, 13 Jan 2012 21:15:17 +0100

(Reuters) - Seattle Genetics Inc said it found a second instance of a patient on its cancer drug Adcetris developing a deadly brain infection, prompting the company and regulators to include a stronger warning on the drug's label. (Source: Reuters: Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Treatment strategies for initially disseminated intracranial germinomas

Child's Nervous System — Fri, 13 Jan 2012 17:18:42 +0100

Conclusions IDIG patients did not show reduced survival compared to non-dissemination patients if optimal radiotherapy and chemotherapy were used together. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00381-012-1683-2Authors Yi-Wei Chen, Division of Radiation Oncology, Cancer Center, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei, 112 TaiwanPin-I Huang, Division of Radiation Oncology, Cancer Center, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei, 112 TaiwanYu-Wen Hu, Division of Radiation Oncology, Cancer Center, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei, 112 TaiwanDonald Ming-Tak Ho, Depar...

Health Highlights: Jan. 13, 2012

The Doctors Lounge - Health News — Fri, 13 Jan 2012 15:54:00 +0100

Metal Tissue Holders May be Radioactive Lymphoma Drug Adcetris Gets New Warning About Brain Infection U.S. Man Receives Synthetic Windpipe State Governors Urged to Support Concussion Laws Study Links Processed Meat With Increased Risk of Pancreatic Cancer (Source: The Doctors Lounge - Health News)

Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: A pilot study

Pediatric Blood and Cancer — Fri, 13 Jan 2012 12:55:45 +0100

ConclusionsDonepezil was well tolerated among childhood BT survivors who had received substantial prior therapy. Based on improved executive function and memory performance in this pilot trial, a randomized placebo controlled trial of this pharmacologic agent is warranted to fully evaluate its efficacy in remediating neurocognitive dysfunction. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Complications of chemotherapy in neuro-oncology.

Herpes — Fri, 13 Jan 2012 11:30:16 +0100

Authors: Marosi C Abstract The persisting reservation against the use of chemotherapy in patients with malignant glioma was finally overcome by the breakthrough achieved with the use of the oral alkylating agent temozolomide (TMZ) as concomitant and adjuvant chemotherapy in patients with newly diagnosed glioblastoma multiforme (GBM). The basic condition for an effective systemic drug therapy against malignant glioma is that the drug be able to cross the blood-brain barrier (BBB) and the brain-tumor barrier. Drugs crossing the BBB have to be nonpolar, small molecules with a molecular weight of less than 500Da, to bear no electrical charge, or to be able to use active transport mechanisms, as the BBB is functional in the peripheral growing areas of GBM. The prerequisite of liposolubi...

Gene therapy.

Herpes — Fri, 13 Jan 2012 11:30:16 +0100

Authors: Gomez-Manzano C, Jiang H, Alonso M, Yung WK, Fueyo J Abstract During the last 10 years, gene therapy for brain tumors has known peaks and valleys. The first attempts to induce therapeutic effect, using retrovirus to transduce the HSV-TK gene and adenovirus to transfer wild-type p53 cDNA, failed significantly to improve the survival of the patients. In both cases, the failure was attributed to vector deficiencies, also termed the 'vector gap'. To address the problem of delivery, investigators have moved from replication-deficient vectors to replication-competent, tumor-selective viruses. These viruses are currently being tested in the clinical setting. In this review, we discuss the progress made with herpes simplex viruses (G207), reoviruses that naturally target Ras pathw...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Brain Tumors Sensitized To Chemotherapy By Selectively Stopping Glutathione

Health News from Medical News Today — Fri, 13 Jan 2012 09:00:00 +0100

Brain cancer cells are particularly resistant to chemotherapy - toxins enter the cells, but before the toxins can kill, cancer cells quickly pump them back outside. In fact, brain cancer cells are even better than healthy cells at cleaning themselves. This means that when hit with chemotherapy, healthy cells tend to die before brain cancer cells. Especially in the brain, killing healthy cells is bad. Researchers at the University of Colorado Cancer Center have discovered a way to turn off the pumps - only in brain cancer cells and not in their healthy neighbors... (Source: Health News from Medical News Today)

MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis

Nucleic Acids Research — Fri, 13 Jan 2012 05:00:00 +0100

Genomic meta-analysis to combine relevant and homogeneous studies has been widely applied, but the quality control (QC) and objective inclusion/exclusion criteria have been largely overlooked. Currently, the inclusion/exclusion criteria mostly depend on ad-hoc expert opinion or naïve threshold by sample size or platform. There are pressing needs to develop a systematic QC methodology as the decision of study inclusion greatly impacts the final meta-analysis outcome. In this article, we propose six quantitative quality control measures, covering internal homogeneity of coexpression structure among studies, external consistency of coexpression pattern with pathway database, and accuracy and consistency of differentially expressed gene detection or enriched pathway identification. Each q...

Juvenile exposure to methylphenidate reduces cocaine reward and alters netrin-1 receptor expression in adulthood.

Behavioural Brain Research — Fri, 13 Jan 2012 05:00:00 +0100

We examined in C57/BL6 mice the effects of repeated juvenile methylphenidate (MPH) exposure on cocaine-reward sensitivity in adulthood and determined whether early MPH treatment alters adult expression of DCC in mesocorticolimbic DA regions. By using place conditioning, we show that adult mice exposed to MPH during the juvenile period are less sensitive to cocaine-reward compared to saline-controls. Furthermore, by means of immunoblotting, we demonstrate that early MPH treatment attenuates adult DCC expression in the ventral tegmental area (VTA) selectively. These results support previous evidence that developmental MPH treatment diminishes cocaine-reward in adulthood and are the first to suggest that DCC in the VTA may participate in this enduring effect. PMID: 22249134 [PubMed - as s...

Impact of Molecular Biology Studies on the Understanding of Brain Tumors in Childhood

Current Oncology Reports — Thu, 12 Jan 2012 06:42:58 +0100

Abstract Pediatric brain tumors are the second most common form of childhood malignancy. Brain tumors are a very heterogenous group of tumors and the pathogenesis of many of these tumors is yet to be clearly elucidated. Current diagnostic tools include histopathology and immunohistochemistry, but classification based on these means has significant limitations. As our understanding of the molecular biology of individual tumors continues to increase it has led to the identification of reliable and increasingly available molecular biomarkers. Molecular techniques are likely to complement current standard means of investigation and help not only overcome diagnostic challenges but may also result in better disease classification and risk stratification, leading to more personal...

Spurious progression in pediatric brain tumors

Journal of Neuro-Oncology — Thu, 12 Jan 2012 06:42:15 +0100

In this study, we sought to characterize post-therapy MRI changes mimicking progression, which we refer to as “spurious progression” (SP) in children with brain tumors. We analyzed whether SP is associated with particular tumor types or therapeutic modalities. Between 2000 and 2009, we identified 181 consecutive children <21 years of age at our center who were treated for brain tumors and had at least three MRI scans within a year after completing therapy. SP was defined as MRI abnormalities characterized by increase in size, enhancement, edema, or cystic changes within 12 months following therapy, and stabilization or improvement on subsequent imaging. One-hundred forty-one patients with brain tumors were evaluable. Fifty-six (40%) had imaging abnormalities initiall...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Phase I study of lapatinib plus vinorelbine in patients with locally advanced or metastatic breast cancer overexpressing HER2

British Journal of Cancer AOP — Thu, 12 Jan 2012 05:00:00 +0100

Authors: E Brain, N Isambert, F Dalenc, V Diéras, J Bonneterre, K Rezai, M Jimenez, F Mefti-Lacheraf, E Cottura, P Tresca, L Vanlemmens, C Mahier-Aït Oukhatar, F Lokiec & P Fumoleau (Source: British Journal of Cancer AOP)

Tumor necrosis factor-alpha-mediated threonine 435 phosphorylation of p65 nuclear factor-kappaB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus

Journal of Neuroinflammation — Thu, 12 Jan 2012 05:00:00 +0100

Conclusion: These findings suggest that impairments of endothelial cell functions via TNF-alpha-mediated p65-Thr 485 NF-kappaB phosphorylation may be involved in SE-induced vasogenic edema. Subsequently, vasogenic edema results in extensive neutrophil infiltration and neuronal-astroglial loss. (Source: Journal of Neuroinflammation)

Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma [BRAIN]

American Journal of Neuroradiology — Thu, 12 Jan 2012 05:00:00 +0100

CONCLUSIONS: rCBV provides a reliable estimation of tumor MVA as a biomarker of glioma outcome. rCBV poorly estimates MVD in the presence of vessel size heterogeneity inherent to human HGG. (Source: American Journal of Neuroradiology)

Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging

Annals of Neurology — Thu, 12 Jan 2012 05:00:00 +0100

AbstractObjective:The goal of the current study was to examine the dynamics of language lateralization using magnetoencephalographic (MEG) imaging, to determine the sensitivity and specificity of MEG‐imaging, and to determine if MEG‐imaging can become a viable alternative to the intracarotid amobarbital procedure (IAP), the current gold‐standard for preoperative language lateralization in neurosurgical candidates.Methods:MEG was recorded during an auditory verb‐generation task and imaging analysis of oscillatory activity was initially performed in 21 subjects with epilepsy, brain tumor, or arteriovenous malformation who had undergone IAP and MEG. Time‐windows and brain regions‐of‐interest that best discriminated between IAP determined left or right dominant for language were ...