MedWorm: Breast Cancer

Clinical Chemistry and Laboratory Medicine — Wed, 01 Jul 2009 18:41:13 +0100

Clinical Chemistry and Laboratory Medicine 47 (S1): S77-S105 Abstract Use of biomarkers in heart disease Standardisation of HbA1c The power of networking Personnalized health care – what it takes to be a leader Integrated diagnostics – what do you think the next generation of healthcare will look like? Biochips can save lives: cardiovascular disease The future and importance of solution business What is new on cardiac troponin? Diagnostic performance and clinical value of holotranscobalamin, measured by the AxSYM Active-B12 assay, for vitamin B12 status Directing the spotlight on renal disease Automation solutions for laboratories in hospital networks Beyond blood Complementary role of serology and NAT in the diagnosis of viral hepatitis New developments in prostate cancer management A...

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GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells

Biological Chemistry — Wed, 01 Jul 2009 18:20:08 +0100

Biological Chemistry 390 (7): 601-609 Abstract The disialoganglioside GD3 is an oncofetal marker of a variety of human tumors including melanoma and neuroblastoma, playing a key role in tumor progression. GD3 and 9-O-acetyl-GD3 are overexpressed in approximately 50% of invasive ductal breast carcinoma, but no relationship has been established between disialoganglioside expression and breast cancer progression. In order to determine the effect of GD3 expression on breast cancer development, we analyzed the biosynthesis of gangliosides in several breast epithelial cell lines including MDA-MB-231, MCF-7, BT-20, T47-D, and MCF10A, by immunocytochemistry, flow cytometry, and real-time PCR. Our results show that, in comparison to tumors, cultured breast cancer cells express a limited pattern of ...

Protein Linked To Change In Tissue That Surround And Support Breast Tumors

ScienceDaily Headlines — Wed, 01 Jul 2009 18:19:04 +0100

A protein known to be overly active in breast cancer can exist in a form that seems to change the structural composition of mammary tissue, potentially making it more conducive to tumor progression, say researchers. (Source: ScienceDaily Headlines)

Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians

Cancer Detection and Prevention — Wed, 01 Jul 2009 15:01:19 +0100

Conclusions: The results indicate that the VDR poly-A polymorphism is significantly associated with breast cancer risk in north Indians especially with early onset disease. Although, ApaI and TaqI did not show any significant association with the disease when analyzed in isolation, but TaqI might modulate the risk associated with L alleles. Further, understanding the functional role of these variants residing on the VDR haplotype associated with disease susceptibility may suggest novel approaches for breast cancer prevention and therapy. (Source: Cancer Detection and Prevention)

Adjuvant Radiotherapy Reduces Recurrences With Small Breast Tumors

OncologySTAT Latest News — Wed, 01 Jul 2009 14:58:41 +0100

ORLANDO (EGMN) - The use of adjuvant radiation therapy following mastectomy reduced the risk of locoregional and distant recurrence among breast cancer patients with tumors measuring less than 5 cm and... (Source: OncologySTAT Latest News)

Rwanda: Breast Cancer Treatment Research Lacks Funding- Activist

AllAfrica News: Health and Medicine — Wed, 01 Jul 2009 11:33:53 +0100

Breast cancer, a highly prevalent health problem in the country lacks funding for awareness, screening and treatment - the Director of East African Breast Cancer Initiative (EABCI), yesterday revealed. (Source: AllAfrica News: Health and Medicine)

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BioSante Pharmaceuticals Comments On Study Showing No Increased Risk Of Breast Cancer In Women Using Testosterone For Low Libido

Health News from Medical News Today — Wed, 01 Jul 2009 10:00:00 +0100

BioSante Pharmaceuticals, Inc. (Source: Health News from Medical News Today)

ABRAXANE Approved For Advanced Breast Cancer Patient Treatment In Quebec

Health News from Medical News Today — Wed, 01 Jul 2009 10:00:00 +0100

Abraxis BioScience, Inc. (NASDAQ:ABII), an integrated biotechnology company, announced the listing of ABRAXANE® for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) 100 mg in Quebec for the treatment of metastatic breast cancer with a recommendation from the Quebec Conseil du MÃ©dicament and approval from the Quebec Ministry of Health. (Source: Health News from Medical News Today)

Metabolic Factors May Play A Role In Risk For Breast Cancer

Health News from Medical News Today — Wed, 01 Jul 2009 09:00:00 +0100

Physiological changes associated with the metabolic syndrome may play a role in the risk of postmenopausal breast cancer, according to study results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. (Source: Health News from Medical News Today)

XCounter Announces Positive Results Following Independent Clinical Evaluation Of XC Mammo -3T Prototype

Health News from Medical News Today — Wed, 01 Jul 2009 07:00:00 +0100

XCounter AB (publ) (AIM:XCT), a technology leader in the development of tomosynthesis-based 3D medical imaging, announced positive initial results from the first clinical evaluation of its innovative breast screening device XC Mammo - 3T. The device is the world's first dedicated 3D digital mammography system for the detection of breast cancer, the most common form of cancer found in women. (Source: Health News from Medical News Today)

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

EurekAlert! - Medicine and Health — Wed, 01 Jul 2009 04:00:00 +0100

(Lifespan) New research at Rhode Island Hospital has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer. (Source: EurekAlert! - Medicine and Health)

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Cancer: An Ounce of Prevention

Psychology Today — Wed, 01 Jul 2009 04:00:00 +0100

Exercise and eat away your risk for breast cancer. (Source: Psychology Today)

BRCA1 Gene

About.com Breast Cancer — Tue, 30 Jun 2009 23:00:00 +0100

BRCA1 is a gene that, when healthy, prevents breast tumors from forming. It is associated with hereditary breast cancer. (Source: About.com Breast Cancer)

MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

A controversy has arisen over the past several years about the true origin of the human MDA-MB-435 cell line. Originally described as a human breast cancer cell line, subsequent expression array studies instead suggested a gene expression profile consistent with a melanoma origin. Subsequent karyotype and comparative genomic hybridization studies supported the idea that current stocks of both MDA-MB-435 cells and M14 melanoma cells must be identical cell lines, and the conclusion was drawn that both cell lines were in fact M14 melanoma cells. However, an alternate conclusion based on these data is that both cell lines are indeed identical, but are in fact MDA-MB-435 breast cancer cells. There is evidence that many cell lines can display "lineage infidelity" and that assignment to tissue ty...

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial and Mesenchymal Phenotype Conversions in Breast Cancer

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggressive tumors. PGI/AMF has been correlated significantly with breast cancer progression and poor prognosis in breast cancer. We show here that ectopic expression of PGI/AMF induced epithelial-to-mesenchymal transition (EMT) in MCF10A normal human breast epithelial cells, and inhibition of PGI/AMF expression triggered mesenchymal-to-epithelial transition (MET) in aggressive mesenchymal-type human breast cancer MDA-MB-231 cells. EMT in MCF10A cells was shown by morphologic changes and loss of E-cadherin/β-catenin–mediated cell-cell adhesion, which is concomitant with ...

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

The establishment of metastasis depends on the ability of cancer cells to acquire a migratory phenotype combined with their capacity to recreate a secondary tumor in a distant tissue. In epithelial cancers, such as those of the breast, the epithelial-mesenchymal transition (EMT) is associated with basal-like breast cancers, generates cells with stem-like properties, and enables cancer cell dissemination and metastasis. However, the molecular mechanism(s) that connects stem cell–like characteristics with EMT has yet to be defined. Using an orthotopic model of human breast cancer metastasis to lung, we identified a poor prognosis gene signature, in which several components of the wnt signaling pathway were overexpressed in early lung metastases. The wnt genes identified in this signatu...

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Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

Lymphopenia is frequent in advanced cancers and predicts the toxicity of chemotherapy. Its effect on relapse and survival is uncertain. Its prognostic value for survival was analyzed in three databases of previously reported prospective multicenter studies: (a) FEC chemotherapy in metastatic breast carcinoma; (b) CYVADIC in advanced soft tissue sarcoma (European Organization for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group 62791); and (c) prospective, consecutive phase III studies of aggressive diffuse large-cell non–Hodgkin's lymphomas conducted at Centre Léon Bérard between 1987 and 1993. Univariate and multivariate analyses of prognostic factors for survival were performed. The incidence of lymphopenia of <1,000/µL before treatme...

Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

In conclusion, the regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer. [Cancer Res 2009;69(13):5392–9] (Source: Cancer Research)

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues that reduce cell migration and invasion and cause regression of orthotopic breast tumors in vivo. Two diastereoisomeric -bromophosphonates (BrP-LPA) were synthesized, and the pharmacology was determined for five LPA G protein–coupled receptors (GPCRs). The syn and anti diastereomers of BrP-LPA are pan-LPA GPCR antagonists and are also nanomolar inhibitors of the lysophospholipase D activity of autotaxin, the dominant biosynthetic source of LPA. Computational models correctly predicted the diastereoselectivity of antagonism for three GPCR isoforms. The anti isomer of BrP-LPA was more effective than syn isome...

Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer

BMC Cancer — Tue, 30 Jun 2009 23:00:00 +0100

Conclusions: Although the Wnt antagonist genes WIF1 and DKK3 show a very similar frequency of promoter methylation in human breast cancer, only DKK3 methylation proves as a novel prognostic marker potentially useful in the clinical management of this disease. (Source: BMC Cancer)

Multigene Classifiers, Prognostic Factors, and Predictors of Breast Cancer Clinical Outcome

Advances in Anatomic Pathology — Tue, 30 Jun 2009 23:00:00 +0100

A series of multigene classifiers, prognostic and predictive tests have recently been introduced as potentially useful adjuncts for the management of recently diagnosed breast cancer patients. These tests have used both slide-based methods including immunohistochemistry and fluorescence in situ hybridization and nonmorphology driven molecular platforms including quantitative multiplex real time polymerase chain reaction and genomic microarray profiling. In this review, a series of partially and completely commercialized multigene assays are compared with the standard breast cancer clinico-pathologic variables and biomarkers and evaluated as to the level of their scientific validation, current clinical utility, regulatory approval status, and estimated cost-benefit. A comparison of the Onco...

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Triple negative breast cancer: a study from the point of view of basal CK5/6 and HER-1.

Cancer Control — Tue, 30 Jun 2009 23:00:00 +0100

CONCLUSION: Expression of CK5/6 and HER-1 is frequent in ER-negative breast cancers, in triple negative and in non-triple negative tumours. In a minority of cases, HER-1 overexpression may be caused by HER-1 gene amplification. Further studies are needed to investigate whether such cases might benefit from anti-HER-1 therapy. PMID: 19561231 [PubMed - in process] (Source: Cancer Control)

Identification Of Osteopontin-Dependent Signaling Pathways In Human Breast Cancer

BMC Research Notes — Tue, 30 Jun 2009 23:00:00 +0100

Conclusion: We conclude that secreted OPN regulates multiple signaling pathways critical for local tumor progression. (Source: BMC Research Notes)

Do high-volume hospitals and surgeons provide better care in urologic oncology?

Urologic Oncology: Seminars and Original Investigations — Tue, 30 Jun 2009 23:00:00 +0100

Abstract: Studies focusing primarily on hospital or surgical volume as a surrogate for surgical experience have found substantial variations in outcomes. Increasing surgical experience has been shown to improve outcomes after multiple procedures, including esophagectomy, pancreatectomy, and primary surgery for colon and breast cancer. More recently, evidence has been presented that surgical volume/experience affects quality of life and cancer control outcomes after urologic oncology procedures. Although most of these data pertain to radical prostatectomy, similar conclusions have been reached for radical cystectomy, retroperitoneal lymph node dissection, and management of renal cell carcinoma. This review highlights data indicating that high-volume surgeons and hospitals provide better car...

Breast cancer treatments impact work status

Reuters: Health — Tue, 30 Jun 2009 20:28:56 +0100

NEW YORK (Reuters Health) - Among working women with newly diagnosed breast cancer, those treated with chemotherapy appear more likely to experience a major change in work status, study findings suggest. (Source: Reuters: Health)

Breast Cancer Treatments Impact Work Status

MedlinePlus Health News — Tue, 30 Jun 2009 19:28:56 +0100

Among working women with newly diagnosed breast cancer, those treated with chemotherapy appear more likely to experience a major change in work status, study findings suggest. Source: Reuters Health Related MedlinePlus Topics: Breast Cancer, Cancer Chemotherapy, Radiation Therapy (Source: MedlinePlus Health News)

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Metabolic Syndrome May Make Breast Cancer More Likely

MedlinePlus Health News — Tue, 30 Jun 2009 18:00:00 +0100

Study finds increased risk for postmenopausal women Source: HealthDay Related MedlinePlus Topics: Breast Cancer, Metabolic Syndrome (Source: MedlinePlus Health News)

Metabolic Syndrome Linked to Breast Cancer Risk (CME/CE)

MedPage Today Cardiovascular — Tue, 30 Jun 2009 17:00:00 +0100

LITTLE FALLS, N.J. (MedPage Today) -- The metabolic syndrome appears to be related to an increased risk for breast cancer in postmenopausal women, a longitudinal study showed. (Source: MedPage Today Cardiovascular)

New Take On Growth Factor Signaling In Tamoxifen Resistance

ScienceDaily Headlines — Tue, 30 Jun 2009 16:22:59 +0100

Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling. (Source: ScienceDaily Headlines)

RNA Snippet Suppresses Spread Of Aggressive Breast Cancer

ScienceDaily Headlines — Tue, 30 Jun 2009 12:00:00 +0100

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers. Measuring levels of this so-called microRNA in cancer cells may more accurately predict the likelihood of metastasis, the spread of cancer to other parts of the body that accounts for 90 percent of cancer-related deaths. (Source: ScienceDaily Headlines)

New light therapy treatment destroys breast cancer cells

Nursing Times Breaking News — Tue, 30 Jun 2009 10:30:00 +0100

Scientists are to unveil a groundbreaking non-invasive light treatment for breast cancer at this year’s Royal Society Summer Science Exhibition. (Source: Nursing Times Breaking News)

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Bilateral Mastectomy for DCIS is Increasing

Breast Cancer Chronicles — Tue, 30 Jun 2009 09:28:41 +0100

More and more young (premenopausal) women who are diagnosed with noninvasive breast cancer (or DCIS, ductal carcinoma in situ) are opting for mastectomies—the most aggressive surgery they can get. (Source: Breast Cancer Chronicles)

Uganda: Mulago Cancer Institute to Start Community Breast Cancer Screening

AllAfrica News: Health and Medicine — Tue, 30 Jun 2009 09:24:56 +0100

UGANDAN women have for long only rushed for clinical breast cancer screening to ascertain whether the lumps in their breasts are cancerous or not. But with the introduction of mobile breast cancer screening in communities, the National Cancer Institute, Mulago is moving away from diagnostic screening to a more preventive clinical procedure, where the pre-cancer cells are identified long before women even notice the lump. (Source: AllAfrica News: Health and Medicine)

New MRI Technique Could Mean Fewer Breast Biopsies In High-Risk Women

Health News from Medical News Today — Tue, 30 Jun 2009 09:00:00 +0100

A University of Wisconsin-Madison biomedical engineer and colleagues have developed a method that, applied in MRI scans of the breast, could spare some women with increased breast cancer risk the pain and stress of having to endure a biopsy of a questionable lump or lesion. (Source: Health News from Medical News Today)

Light Therapy Offers New Hope For Breast Cancer Patients

Cancer / Oncology News From Medical News Today — Tue, 30 Jun 2009 07:00:00 +0100

A groundbreaking non-invasive breast cancer treatment will be unveiled at this year's Royal Society Summer Science Exhibition . Scientists led by world-renowned breast cancer expert, Mr Mo Keshtgar, are the first to use photodynamic therapy (PDT) to treat what is now the most common cancer in the UK. (Source: Cancer / Oncology News From Medical News Today)

Dual Role In Breast Tissue For Protein Involved In Leukemia

ScienceDaily Headlines — Tue, 30 Jun 2009 06:00:00 +0100

A protein known to play a role in growth of some types of leukemia appears to have a mixed function in breast cancer development, say researchers. (Source: ScienceDaily Headlines)

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Breast Cancer Decline

Medical Headlines From Ivanhoe.com — Tue, 30 Jun 2009 05:00:00 +0100

Researchers know breast cancer rates declined significantly after reports in 2002 linking hormone replacement therapy with a higher risk of the disease. (Source: Medical Headlines From Ivanhoe.com)

Breast cancer imaging program expedites diagnostic process

Baylor College of Medicine News — Tue, 30 Jun 2009 05:00:00 +0100

A Houston team has reduced what is often the most difficult part of breast cancer detection tests – waiting for the results, said a breast imaging specialist at Baylor College of Medicine . "Early detection is the single most important way to increase a patient's chance of survival," said Dr. Emily Sedgwick, director of breast imaging in the Lester and Sue Smith Breast Center at BCM. "Our process of gathering the diagnostic mammogram, ultrasound and biopsy in one day decreases the patient's wait time and anxiety. Hopefully, this will make them more likely to come in for their annual mammograms and detect their cancers earlier." Other breast imaging centers, Sedgwick said, may have patients set up separate appointments for each 'test step,' wait for results and the...

Metabolic factors may play a role in risk for breast cancer

EurekAlert! - Social and Behavioral Science — Tue, 30 Jun 2009 04:00:00 +0100

(American Association for Cancer Research) Physiological changes associated with the metabolic syndrome may play a role in the risk of postmenopausal breast cancer, according to study results published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Social and Behavioral Science)

Occult tumor cells linked to lobular breast cancer type

MedWire News - Oncology — Tue, 30 Jun 2009 00:00:00 +0100

French researchers have found that the spread of occult tumor cells in small invasive breast cancers may be associated with a lobular histology, but is independent of classical tumor histologic factors. (Source: MedWire News - Oncology)

[Reflection and Reaction] Understanding and preventing local tumour recurrence

The Lancet Oncology — Mon, 29 Jun 2009 23:00:00 +0100

We read with great interest the Personal View in the April issue, from Mariella Mannino and John Yarnold, which gave striking support that early invasive breast cancer conforms to two hypotheses proposed for malignant tumours in general. The hypotheses state that the local spread of cancer is confined for a long period to a permissive compartment traced back to embryonic development, and that local relapse might be promoted by the wound-healing response to surgical resection if remnants of the compartment remain in situ and harbour or recruit residual tumour (stem) cells. (Source: The Lancet Oncology)

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[From the Archives] Preserving life and conserving the breast

The Lancet Oncology — Mon, 29 Jun 2009 23:00:00 +0100

For most of the 20th century, the standard treatment for breast cancer was Halsted mastectomy. This was often curative, but by any standards was mutilating: removing the entire breast, the pectoralis major and minor muscles, a good deal of skin, and the axillary lymph nodes. The 5-year results of the Milan I trial, published in 1981, provided the first strong scientific evidence that breast-conserving surgery followed by radiotherapy to the operated breast is equivalent to mastectomy as treatment for early breast cancer (less than 2 cm in diameter). 4 years later Fisher and colleagues published the 5-year results of their landmark trial on 1843 patients, 1257 of whom initially received breast-conserving surgery. The trial showed that breast conservation is suitable treatment for women with...

Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

Journal of Experimental and Clinical Cancer Research — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions: Prx I and Trx1 are overexpressed in human breast carcinoma and the expression levels are associated with tumor grade. The striking induction of Prx I and Trx1 in breast cancer may enable their use as breast cancer markers. (Source: Journal of Experimental and Clinical Cancer Research)

Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis

Radiation Oncology — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions: The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter. (Source: Radiation Oncology)

Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer

Journal of Surgical Oncology — Mon, 29 Jun 2009 23:00:00 +0100

Hyaluronic acid binding protein 1 (HABP1), a family of proteins interacting with hyaluronan (HA), had been associated with cell adhesion and tumor invasion. The aim of this study was to investigate the correlation between clinicopathologic factors and patient survival time with the expression of HABP1 in breast cancer patients.Expression of HABP1 mRNA and protein were detected with real-time quantitative PCR and immunohistochemical staining in 63 breast cancer and non-cancerous matched tissues.The mRNA expression level of HABP1 was unrelated to the patient's age, tumor size, histological grade, TNM stage. However, it proved to be positively related to axillary nodes metastasis (P = 0.008). Furthermore, it was shown that the survival rate of patients with low HABP1 expression was significan...

Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study

BMC Cancer — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions: These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of omega-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk. (Source: BMC Cancer)

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The role of YY1 in reduced HP1 alpha gene expression in invasive human breast cancer cells

Breast Cancer Research — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions: Our data suggests that a reduction of YY1 expression in breast cancer cells could contribute to the acquisition of an invasive phenotype through increased cell migration as well as by reduced expression of HP1alpha. (Source: Breast Cancer Research)

Breast ductal endoscopy: how many procedures qualify?

BMC Research Notes — Mon, 29 Jun 2009 23:00:00 +0100

CONCLUSION: These pilot findings point to approximately 13 procedures as a point beyond which ductal endoscopy is successfully performed; studies on a larger number of fellows are nevertheless needed. Further research, focusing on the learning curves of different training models of ductal endoscopy, seems desirable. (Source: BMC Research Notes)

Possible Link Between Insulin Glaragine and Cancer Prompts Urgent Call for More Research

Diabetes News from dLife.com — Mon, 29 Jun 2009 23:00:00 +0100

June 30, 2009 (Diabetologia) - Worldwide, there are over 200 million people with diabetes. About 10% of these develop diabetes in early life, and most of them have what is known as type 1 diabetes. People with type 1 diabetes have an absolute reliance upon insulin treatment for their continued health and well-being. Type 2 diabetes, which affects the remaining 90%, typically develops later in life and may be associated with excess weight. People with type 2 diabetes are able to make some of their own insulin, which means that they can usually be treated with diet and tablets in its early stages. At a later stage, however, many patients with type 2 diabetes lose the ability to produce their own insulin, and will then need insulin injections to maintain their health. Human insulin has be...

Possible Link Between Insulin Glaragine and Cancer Prompts Urgent Call for More Research

Diabetes News from dLife.com — Mon, 29 Jun 2009 23:00:00 +0100