MedWorm: Breast Cancer

Tamoxifen and raloxifene effect cognitive function equally

MedWire News - Oncology — Fri, 06 Nov 2009 13:48:19 +0100

Tamoxifen and raloxifene are associated with similar patterns of cognitive function in postmenopausal women at increased risk for breast cancer, indicate data from a multicenter study. (Source: MedWire News - Oncology)

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Tamoxifen and raloxifene effect cognitive function equally

MedWire News - Breast Cancer — Fri, 06 Nov 2009 13:48:18 +0100

ASTRO: Post-lumpectomy breast cancer RT can be safely reduced to four weeks

Health Imaging News — Fri, 06 Nov 2009 12:18:25 +0100

Post-lumpectomy radiation treatment for early-stage breast cancer can be safely reduced to four weeks by delivering a higher daily dose according to the five-year results of a phase II study presented Wednesday at the 2009 American Society for Radiation Oncology (ASTRO) in Chicago. (Source: Health Imaging News)

ASTRO: Post-lumpectomy breast cancer RT can be safely reduced to four weeks

Health Imaging News — Fri, 06 Nov 2009 12:18:25 +0100

Plastic Surgeons Offer Microsurgery Technique For Breast Reconstruction, Tummy Tuck After Mastectomy

Breast Cancer News From Medical News Today — Fri, 06 Nov 2009 10:00:00 +0100

Since her teens, Jennifer Jablon had watched family members deal with breast cancer during their 40s, 50s, and 60s. She wondered whether it would be her fate too. In her mid-50s, Jennifer's mother was diagnosed with breast cancer and tested positive for the recently identified BRCA1 gene, indicating a genetic predisposition to breast cancer. "I spent about six months in denial after my mom tested positive. (Source: Breast Cancer News From Medical News Today)

Plastic Surgeons Offer Microsurgery Technique For Breast Reconstruction, Tummy Tuck After Mastectomy

Health News from Medical News Today — Fri, 06 Nov 2009 10:00:00 +0100

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£50,000 boost in cancer funds

Scotsman.com News - Health — Fri, 06 Nov 2009 00:00:00 +0100

CITY fundraisers have raised up to £50,000 for a debut event by Breast Cancer Campaign. (Source: Scotsman.com News - Health)

Three-Week Course Of Breast Radiation May Be As Effective As Conventional Five To Seven Week Course For Early Breast Cancers

Cancercompass News: Breast Cancer — Fri, 06 Nov 2009 00:00:00 +0100

According to a study presented November 4, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO), a shortened, more intensive course of radiation given to the whole breast, along with an extra dose of radiation given to the surgical bed of the tumor (concomitant boost), has been shown to result in excellent local control at a median follow up of two years after treatment with no significant side effects. (Source: Cancercompass News: Breast Cancer)

[Editorial] Breast cancer in developing countries

LANCET — Fri, 06 Nov 2009 00:00:00 +0100

Globally, breast cancer is the most common cause of cancer-related death in women, with some 327 000 deaths each year. There are 1·35 million new cases every year, and about 4·4 million women are believed to be living with breast cancer. An estimated 1·7 million women will be diagnosed with breast cancer in 2020—a 26% increase from current levels—mostly in the developing world. Breast cancer is already the leading cause of cancer in southeast Asian women, and is second only to gastric cancer in east Asian women, and to cervical cancer in women in south-central Asia. In India, almost 100 000 women are diagnosed with breast cancer every year, and a rise to 131 000 cases is predicted by 2020. To meet this important and growing health challenge, a team of researchers has established ...

Synthesis, characterization and anticancer activity of new palladacycles derived from chiral [alpha]-diimines

Applied Organometallic Chemistry — Fri, 06 Nov 2009 00:00:00 +0100

Optically pure [alpha]-diimines quantitatively obtained in solvent-free conditions starting from 2,3-butanedione and (S)-(-)-1-phenylethylamine and (S)-(-)-1-(4-methylphenyl)ethylamine, respectively, yielded the new chiral mono-Pd complexes 2a-b, which have been partly characterized by IR, 1H- and 13C-NMR spectroscopies along with MS-FAB+ spectrometry. The crystal and molecular structure for palladacycle 2a has been fully confirmed by single-crystal X-ray studies. Studies in vitro of 2a-b have displayed growth inhibition against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), breast cancer (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Applied Organometallic Chemistry)

Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients.

International Journal of Oncology — Thu, 05 Nov 2009 22:16:43 +0100

Authors: Vazquez-Martin A, Fernandez-Real JM, Oliveras-Ferraros C, Navarrete JM, Martin-Castillo B, Del Barco S, Brunet J, Menendez JA Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN) could associate with circulating HER2 extracellular domain (HER2 ECD) in the blood of metastatic breast cancer (MBC) patients. Concentrations of serum FASN and HER2 ECD were measured with ELISA in sera retrospectively obtained from 201 patients with metastatic breast cancer (MBC) and 31 healthy subjects. Mechanistical in vitro studies wer...

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Cell density-dependent regulation of p73 in breast cancer cells.

International Journal of Oncology — Thu, 05 Nov 2009 22:16:27 +0100

Authors: Tophkhane C, Yang S, Zhao ZJ, Yang X Molecular regulation of p73, a p53 family member, remains unclear. Here we report that p73 expression is significantly regulated by cell densities. In particular, we found that p73alpha and p73beta are differentially regulated. While p73beta protein levels were inversely correlated with cell densities, p73alpha protein levels behaved oppositely. We further showed that density-dependent changes of p73alpha follow the same patterns as E2F-1 and TAp73 mRNA levels, suggesting transcriptional regulation. Our data also suggest that high levels of p73beta at lower densities may be due to increased protein stability. However, AIP-4/Itch appeared not to be involved in downregulation of p73beta at high densities. Moreover, we also found that subcellu...

Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells.

International Journal of Oncology — Thu, 05 Nov 2009 22:16:11 +0100

We report that when substitutions are made on the hydroxyl group of 8-OHQ, their copper mixtures have profound effects on the proteasome-inhibitory and apoptosis-inducing abilities in breast cancer MDA-MB-231 cells. In addition, the proteasome-inhibitory and apoptosis-inducing activities of 8-OHQ analog-copper mixtures are determined by both the polarity and position of the substituents. Finally, a synthetic complex of 8-OHQ analog-copper was able to inhibit the proteasome activity, induce cell death and suppress the growth selectively in breast cancer MDA-MB-231 cells, but not in normal immortalized human breast MCF-10A cells. Our results support the concept that human cancer cells and tissues, which contain an elevated copper level and are highly dependent on proteasome activity for thei...

Will There Ever Be a Big Brown Ribbon Outside the White House?

Medscape Today Headlines — Thu, 05 Nov 2009 21:07:52 +0100

In his latest video blog, Dr. John Marshall questions why the pink ribbon/breast cancer awareness promotion attracts more publicity than any other disease campaign. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

FDA Expands Agent's Orphan Drug Status

MedPage Today Product Alert — Thu, 05 Nov 2009 18:02:12 +0100

WASHINGTON (MedPage Today) -- The FDA has extended the orphan drug status of the breast cancer agent protein-bound paclitaxel (Abraxane) for use in stage IIB-IV melanoma treatment. (Source: MedPage Today Product Alert)

Ductal Carcinoma In Situ — A Highly Treatable Breast Cancer

Mayo Clinic Health Information — Thu, 05 Nov 2009 16:53:03 +0100

Doctors and their patients with a specific type of breast cancer called ductal carcinoma in situ (DCIS) are successfully employing treatments to beat the disease, with 10-year survival rates approaching nearly 100 percent. (Source: Mayo Clinic Health Information)

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M. D. Anderson News Release: Early Stage, HER2 Positive Breast Cancer Patients at Increased Risk of Recurrence

Drugs.com - Clinical Trials — Thu, 05 Nov 2009 15:55:40 +0100

Large study finds subset of women that may need additional therapy HOUSTON , Nov. 2, 2009- Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared... (Source: Drugs.com - Clinical Trials)

HEALTH: New Task Force Targets Poor in Breast Cancer Fight

IPS Inter Press Service - Health — Thu, 05 Nov 2009 15:37:28 +0100

NEW YORK, Nov 4 (IPS) - The rate of breast cancer in developing countries is on the rise, according to the Harvard School of Public Health, which estimates that the poor will account for more than 55 percent of breast cancer deaths this year. (Source: IPS Inter Press Service - Health)

Conspicuity of Microcalcifications on Digital Screening Mammograms Using Varying Degrees of Monitor Zooming

Academic Radiology — Thu, 05 Nov 2009 15:19:13 +0100

Conclusions: Images at 30% size should not be relied on alone for systematic scanning for microcalcifications. The other four levels of magnification all performed well enough to warrant further testing. (Source: Academic Radiology)

ASTRO: Modest Benefit Seen with Decongestive Therapy (CME/CE)

MedPage Today Hematology/Oncology — Thu, 05 Nov 2009 15:00:58 +0100

CHICAGO (MedPage Today) -- Breast cancer patients with treatment-related lymphedema derived only a modest benefit from decongestive lymphatic therapy compared with a compression sleeve, results of a randomized multicenter Canadian study showed. (Source: MedPage Today Hematology/Oncology)

pRb loss predicts good outcome in triple negative breast cancer

MedWire News - Oncology — Thu, 05 Nov 2009 13:47:55 +0100

Loss of expression of the retinoblastoma protein is more common in triple-negative breast cancers than in othersubtypes, and is associated with a better outcome after chemotherapy compared with cancers expressing pRb, Italian researchers report. (Source: MedWire News - Oncology)

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Selective Eradication Of Malignant Cells

Health News from Medical News Today — Thu, 05 Nov 2009 13:00:00 +0100

The ultimate goal in cancer research, a treatment that kills cancer cells whilst leaving healthy cells untouched, is brought nearer by the success of a new therapeutic approach. The potential therapy, published in BioMed Central's open access journal Breast Cancer Research, targets proliferation of cancer, but not normal, cells. (Source: Health News from Medical News Today)

Selective Eradication Of Malignant Cells

Breast Cancer News From Medical News Today — Thu, 05 Nov 2009 13:00:00 +0100

Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer.

International Journal of Molecular Medicine — Thu, 05 Nov 2009 12:42:45 +0100

This study was performed to determine the anti-cancer activity of tanshinone IIA on human breast cancer cells in vitro and in vivo and to elucidate the underlying mechanism of this activity. Human breast cancer cell lines (estrogen receptor-positive and -negative) were treated with tanshinone IIA and tamoxifen. The inhibitory effects of tanshinone IIA and tamoxifen on breast cancer cell proliferation were examined using MTT assays, BrdU incorporation, immunohistochemistry and flow cytometry. Upon treatment with tanshinone IIA, breast cancer cell proliferation was significantly inhibited in a dose- and time-dependent manner (IC50 = 0.25 microg/ml) and apoptotic cell populations increased, while tamoxifen inhibited only ER-positive breast cancer cells prominently and had no effect on ER-nega...

Effects of protein kinase Cdelta and phospholipase C-gamma1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death.

International Journal of Molecular Medicine — Thu, 05 Nov 2009 12:42:12 +0100

Authors: Kim YS, An HT, Kim J, Ko J Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine that plays an important role in immune cell migration. It has been reported that chemokines, including MCP-1, are involved in angiogenesis and metastasis. However, the exact role of chemokines in cancer development is still obscure. We investigated the involvement of MCP-1 in taxol-induced breast cancer cell death. The anti-cancer drug taxol induced MCF-7 breast cancer cell death. Treatment with taxol increased the mRNA expression level of MCP-1 in a dose- and time-dependent manner. Up-regulation of MCP-1 by taxol was augmented in cells treated with rottlerin, a specific inhibitor of protein kinase Cdelta (PKCdelta). In addition, taxol-induced MCP-1 expression was reduced by the ectopic exp...

Radiation Therapy After Lumpectomy For Breast Cancer Can Be Safely Reduced To 4 Weeks

Radiology / Nuclear Medicine News From Medical News Today — Thu, 05 Nov 2009 12:00:00 +0100

Researchers at Fox Chase Cancer Center found that radiation treatment for women who had a lumpectomy for early-stage breast cancer can be safely reduced to four weeks, instead of the usual six to seven weeks, by delivering a higher daily dose - greatly reducing the length of treatment time. The five-year results of the phase II study were presented at the annual meeting of the American Society for Radiation Oncology. (Source: Radiology / Nuclear Medicine News From Medical News Today)

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Radiation Therapy After Lumpectomy For Breast Cancer Can Be Safely Reduced To 4 Weeks

Health News from Medical News Today — Thu, 05 Nov 2009 12:00:00 +0100

San Antonio Breast Cancer Symposium: CTRC, AACR And Baylor College Of Medicine To Host

Health News from Medical News Today — Thu, 05 Nov 2009 11:00:00 +0100

Premier international conference highlights breakthroughs in breast cancer research What: Now in its 32nd year, the CTRC-AACR San Antonio Breast Cancer Symposium remains the top venue for research and discovery in breast cancer. This year's conference will bring together delegates from all over the world. (Source: Health News from Medical News Today)

San Antonio Breast Cancer Symposium: CTRC, AACR And Baylor College Of Medicine To Host

Breast Cancer News From Medical News Today — Thu, 05 Nov 2009 11:00:00 +0100

Nigeria: Breast Cancer - Women Tasked On Periodic Screening

AllAfrica News: Health and Medicine — Thu, 05 Nov 2009 10:32:18 +0100

PFIZER Global Pharmaceuticals has enjoined all Nigerian women to screen themselves periodically for breast cancer so as to be protected from the debilitating effects of the ailment, saying that early detection saves lives. (Source: AllAfrica News: Health and Medicine)

Experts Seek To Develop Breast Cancer Screening, Treatment In Developing Countries

Breast Cancer News From Medical News Today — Thu, 05 Nov 2009 10:00:00 +0100

An international task force of cancer specialists and charities is meeting this week to develop strategies for curbing rising breast cancer rates in developing countries, the AP/Washington Post reports. The task force is led by Felicia Knaul -- a public health specialist and director of Harvard University's (Source: Breast Cancer News From Medical News Today)

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Experts Seek To Develop Breast Cancer Screening, Treatment In Developing Countries

Health News from Medical News Today — Thu, 05 Nov 2009 10:00:00 +0100

An international task force of cancer specialists and charities is meeting this week to develop strategies for curbing rising breast cancer rates in developing countries, the AP/Washington Post reports. The task force is led by Felicia Knaul -- a public health specialist and director of Harvard University's Global Equity Initiative -- and Lawrence Shulman of the Dana Farber Cancer Institute. (Source: Health News from Medical News Today)

Three-week Course Of Breast Radiation May Be As Effective As Conventional Five To Seven Week Course For Early Breast Cancers

Health News from Medical News Today — Thu, 05 Nov 2009 09:00:00 +0100

Three-week Course Of Breast Radiation May Be As Effective As Conventional Five To Seven Week Course For Early Breast Cancers

Breast Cancer News From Medical News Today — Thu, 05 Nov 2009 09:00:00 +0100

According to a study presented November 4, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO), a shortened, more intensive course of radiation given to the whole breast, along with an extra dose of radiation given to the surgical bed of the tumor (concomitant boost), has been shown to result in excellent local control at a median follow up of two years after treatment with no significant sides effects. (Source: Breast Cancer News From Medical News Today)

Shame of Britain's cancer death rates: Toll is 20% higher than Europe and getting worse

the Mail online | Health — Thu, 05 Nov 2009 08:21:52 +0100

Britain is among the four worst countries for deaths from breast cancer, while deaths from lung cancer are 25 per cent higher than the European average. (Source: the Mail online | Health)

One In Three Breast Cancers Change Form When They Spread, Discover Breakthrough Breast Cancer Scientists

Health News from Medical News Today — Thu, 05 Nov 2009 08:00:00 +0100

Breakthrough Breast Cancer scientists have discovered that over a third of breast cancer tumours change form when they spread, in results published today (Wednesday 4 November) in Annals of Oncology online. Scientists from the Breakthrough Breast Cancer Research Unit at the University of Edinburgh analysed 211 tumours which had spread from the breast to the lymph nodes, in the armpit. (Source: Health News from Medical News Today)

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One In Three Breast Cancers Change Form When They Spread, Discover Breakthrough Breast Cancer Scientists

Breast Cancer News From Medical News Today — Thu, 05 Nov 2009 08:00:00 +0100

Experimental Agent Reduces Breast Cancer Metastasis To Bone

ScienceDaily Headlines — Thu, 05 Nov 2009 07:00:00 +0100

New research finds that a protein called ROCK is over-expressed in metastatic breast cancer and that inhibiting ROCK significantly reduces metastasis to bone. The in vitro and in vivo study suggests that ROCK may be a drug therapy target for breast cancer metastasis. (Source: ScienceDaily Headlines)

Researcher: 'Optical biopsy' for breast cancer increasingly accurate

EurekAlert! - Medicine and Health — Thu, 05 Nov 2009 05:00:00 +0100

(University of Florida) Most biopsies following mammograms reveal benign abnormalities, not cancer. (Source: EurekAlert! - Medicine and Health)

Plastic surgeons offer microsurgery technique for breast reconstruction, tummy tuck after mastectomy

EurekAlert! - Medicine and Health — Thu, 05 Nov 2009 05:00:00 +0100

(UT Southwestern Medical Center) Since her teens, Jennifer Jablon had watched family members deal with breast cancer during their 40s, 50s, and 60s. She wondered whether it would be her fate too. (Source: EurekAlert! - Medicine and Health)

Early-stage, HER2-positive Breast Cancer Patients At Increased Risk Of Recurrence

ScienceDaily Headlines — Thu, 05 Nov 2009 01:00:00 +0100

Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a new study. (Source: ScienceDaily Headlines)

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An occult breast mass

BMJ Online First — Thu, 05 Nov 2009 00:06:23 +0100

(Source: BMJ Online First)

Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation

Breast Cancer Research — Thu, 05 Nov 2009 00:00:00 +0100

Conclusions: Together the data suggest that Hes-6 is a potential oncogene over expressed in breast cancer, with a tumor promoting and proliferative function. Furthermore, Hes-6 is a novel estrogen regulated gene in breast cancer cells. An understanding of the role and regulation of Hes-6 could provide insights into estrogen signaling and endocrine resistance in breast cancer and, hence, be important for the development of novel anticancer drugs. (Source: Breast Cancer Research)

A selective eradication of human non-hereditary breast cancer cells by phenanthridine derived polyADP-ribose polymerase inhibitors

Breast Cancer Research — Thu, 05 Nov 2009 00:00:00 +0100

Conclusions: These results outline a new therapeutic approach for a selective eradication of abundant non-hereditary human breast cancers. (Source: Breast Cancer Research)

FEC with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of Fin-Her Trial

NeLM - Oncology — Thu, 05 Nov 2009 00:00:00 +0100

This report published early online in the Journal of Clinical Oncology presents the final results of the trial. The study involved 1010 women with axillary node-positive or high-risk node-negative breast cancer, randomised to receive 3 cycles of docetaxel or vinorelbine, followed in both groups by 3 cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC). Women with HER2-positive cancer (n = 232) were further assigned to either receive or not receive trastuzumab for 9 weeks with docetaxel or vinorelbine (the authors note that in all other trials reported to date of adjuvant trastuzumab for early HER2-positive breast cancer, the duration of treatment was 12 months or ... (Source: NeLM - Oncology)

ASTRO: Short Course of Breast Cancer Irradiation Effective

Modern Medicine — Thu, 05 Nov 2009 00:00:00 +0100

A three week course of radiation treatment may be as effective as six weeks or more in patients with early-stage breast cancer, according to research presented at the 51st Annual Meeting of the American Society for Radiation Oncology, held from Nov. 1 to 5 in Chicago. In a related study presented at the meeting, adding radiation to the internal mammary lymph nodes does not improve survival in patients with early-stage breast cancer. (Source: Modern Medicine)

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Cut Out, Chemically Bombarded and Burned to Death; This Book Provides Oxygen to an Otherwise Airless Time

Medical News (via PRIMEZONE) — Wed, 04 Nov 2009 23:45:00 +0100

CHICAGO, Nov. 4, 2009 (GLOBE NEWSWIRE) -- There are 50,000 women noted in Marquis' "Who's Who of American Women." Statistics show that 6,250 of these women will get breast cancer. One of these women is Suzanne Zaccone, one of America's most influential entrepreneurs. (Source: Medical News (via PRIMEZONE))

Quick Radiation Works for Breast Cancer

WebMD Health — Wed, 04 Nov 2009 22:42:55 +0100

A shorter, cheaper, and more convenient three-week course of radiation appears to work just as well as the traditional six-week schedule for some women with early-stage breast cancer, a new study suggests. (Source: WebMD Health)

Shorter, More Intense Radiation OK for Some Breast Cancers

MedlinePlus Health News — Wed, 04 Nov 2009 19:00:00 +0100

Three-week course comparable to six-week treatment, researchers find Source: HealthDay Related MedlinePlus Topics: Breast Cancer, Radiation Therapy (Source: MedlinePlus Health News)

ASTRO: Abridged breast radiation treatment effective

Health Imaging News — Wed, 04 Nov 2009 18:40:55 +0100

An abridged, intensified radiation course proved to be as effective as the standard five- to seven-week treatment in early-stage breast cancer patients, based on results of a study presented Wednesday at the 2009 American Society for Radiation Oncology (ASTRO) conference in Chicago. (Source: Health Imaging News)

ASTRO: Abridged breast radiation treatment effective

Health Imaging News — Wed, 04 Nov 2009 18:40:55 +0100

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Breast cancer 'changes' as it spreads

NHS News Feed — Wed, 04 Nov 2009 16:59:00 +0100

Conclusion This study reports that the characteristics of breast tumours may change as they spread through the body. It gives further insight into the behaviour of cancer cells, but its findings will require confirmation in other studies. Other points of note are: Although the study included samples from a relatively large number of women, comparatively few had certain characteristics (for example, those who tested negative for all three proteins). As such, the findings will need to be confirmed by other studies. The study only looked at lymph node metastases (spread). It cannot show what happens when the cancerous cells spread further throughout the body. Although the findings provide a possible reason why cancer treatments may fail, as the researchers report, their study was t...

November eFactor

Environmental Factor - NIEHS Newsletter — Wed, 04 Nov 2009 16:12:26 +0100

Birnbaum Speaks at Milwaukee Town Hall Trainees Turn Out in Record Number for National Postdoc Appreciation Day Fellows and Investigators Showcased at Annual NIH Research Festival First Annual Meeting of the NIEHS Centers for Neurodegeneration Science Shaughnessy Represents NIEHS at Biotech Conference Harry Gives Special Guest Lecture at Stereology Workshop Sister Study Exceeds Recruitment Goal: Now the Real Work Begins WETP Grantees Look at Global Issues in Worker Safety NIEHS Center Intern Recognized by EPA Head Superfund Announces Wetterhahm Award Winner NIEHS Center Director Honored by Oregon State WETP Grantee To Be Nominated for FEMA Post Editorial Recognizes NIEHS-Funded Research Kim Receives Congressionally Directed Medical Research Program Award NIEHS-F...

Merck starts breast-cancer trial

Pharmacy Europe — Wed, 04 Nov 2009 14:11:55 +0100

Drugmaker Merck is to begin breast-cancer trials of Stimuvax in a bid to increase its share of the £29 billion oncology market (Source: Pharmacy Europe)

Weight training for breast cancer survivors

Medicineworld.org: New Article Alert — Wed, 04 Nov 2009 14:04:38 +0100

In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, as per new University of Pennsylvania School of Medicine research. Breast cancer survivors who lift weights regularly feel better about bodies and their appearance and are more satisfied with their intimate relationships compared with survivors who do not lift weights, as per a newly released study reported in the journal Breast Cancer Research and Treatment........ (Source: Medicineworld.org: New Article Alert)

Early menopausal hormone therapy may increase breast cancer risk

MedWire News - Oncology — Wed, 04 Nov 2009 13:53:26 +0100

The timing of estrogen-progestagen menopausal hormone therapy initiation transiently modulates the risk for breast cancer, study findings indicate. (Source: MedWire News - Oncology)

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Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis

Bioinformatics — Wed, 04 Nov 2009 13:45:49 +0100

Motivation: The molecular complexity of a tumor manifests itself at the genomic, epigenomic, transcriptomic and proteomic levels. Genomic profiling at these multiple levels should allow an integrated characterization of tumor etiology. However, there is a shortage of effective statistical and bioinformatic tools for truly integrative data analysis. The standard approach to integrative clustering is separate clustering followed by manual integration. A more statistically powerful approach would incorporate all data types simultaneously and generate a single integrated cluster assignment. Methods: We developed a joint latent variable model for integrative clustering. We call the resulting methodology iCluster. iCluster incorporates flexible modeling of the associations between different data...

It's Safe To Treat HER2-Positive Breast Cancer With Trastuzumab And Adjuvant Radiation, Study Finds

Health News from Medical News Today — Wed, 04 Nov 2009 13:00:00 +0100

Standard adjuvant treatment for HER2-positive breast cancer patients, following primary surgery for their cancer, is Trastuzumab (Herceptin) - typically used in combination with chemotherapy. However, a new study by researchers at Fox Chase Cancer Center reports that it may be safe to treat these patients with both Trastuzumab and adjuvant radiation therapy. (Source: Health News from Medical News Today)

Also In Global Health News: Breast Cancer In Developing World; Burkina Faso ITN Distribution; Diarrhea In People Over Age Five; Gates Q&A

Health News from Medical News Today — Wed, 04 Nov 2009 13:00:00 +0100

Researchers Highlight 'Troubling Increase' In Breast Cancer In Developing Countries "International cancer specialists meet this week to plan an assault on a troubling increase of breast cancer in developing countries, where nearly two-thirds of women aren't diagnosed until it has spread through their bodies," the Associated Press reports. (Source: Health News from Medical News Today)

It's Safe To Treat HER2-Positive Breast Cancer With Trastuzumab And Adjuvant Radiation, Study Finds

Health News from Medical News Today — Wed, 04 Nov 2009 13:00:00 +0100

Also In Global Health News: Breast Cancer In Developing World; Burkina Faso ITN Distribution; Diarrhea In People Over Age Five; Gates Q&A

Health News from Medical News Today — Wed, 04 Nov 2009 13:00:00 +0100

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Task force hopes to deliver affordable cancer drugs to developing countries

BMJ Online First — Wed, 04 Nov 2009 12:40:53 +0100

(Source: BMJ Online First)

Experimental Agent Reduces Breast Cancer Metastasis To Bone

Health News from Medical News Today — Wed, 04 Nov 2009 11:00:00 +0100

Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. (Source: Health News from Medical News Today)

Weight Training Boosts Breast Cancer Survivors' Body Image And Satisfaction With Intimate Relationships

Health News from Medical News Today — Wed, 04 Nov 2009 11:00:00 +0100

In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, according to new University of Pennsylvania School of Medicine research. (Source: Health News from Medical News Today)

Cancer, Pain Relief And Immunity Research Supported By ARC

Health News from Medical News Today — Wed, 04 Nov 2009 09:00:00 +0100

Research at the Walter and Eliza Hall Institute into the genes involved in breast cancer development, new drugs for chronic pain, and the proteins involved in inflammatory diseases has received funding in this year's round of Australian Research Council (ARC) Discovery Project grants. Seven projects proposed by institute researchers have received ARC support. (Source: Health News from Medical News Today)

Women with breast cancer have low vitamin D levels, scientists discover

NaturalNews.com — Wed, 04 Nov 2009 07:00:00 +0100

(NaturalNews) At the American Society of Clinical Oncology's Breast Cancer Symposium held in San Francisco recently, researchers from the University of Rochester Medical Center made an announcement that at first glance may seem startling -- at least it may startle people who are unaware of the preventive and healing power of nutrients. When they studied 166 women undergoing treatment for breast cancer, the scientists found the vast majority, about 70 percent, had something other than their cancer in common: they had very low levels of vitamin D in their blood. What's more, women whose disease had progressed to late-stage (i.e. terminal) cancer had the lowest levels of all.According to the researchers' statement to the media, their take away message about the breast cancer study seems to be...

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Caution in Adding Bevacizumab in the Adjuvant Treatment of Breast Cancer

Annals of Surgical Oncology — Wed, 04 Nov 2009 06:54:52 +0100

Content Type Journal ArticleCategory Medical OncologyDOI 10.1245/s10434-009-0798-5Authors Dimosthenis Ziogas, University of Ioannina Department of Surgery, School of Medicine Ioannina GreeceDimitrios Roukos, University of Ioannina Department of Surgery, School of Medicine Ioannina Greece Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

CTRC, AACR and Baylor College of Medicine to host San Antonio Breast Cancer Symposium

EurekAlert! - Biology — Wed, 04 Nov 2009 05:00:00 +0100

(American Association for Cancer Research) Now in its 32nd year, the CTRC-AACR San Antonio Breast Cancer Symposium remains the top venue for research and discovery in breast cancer. This years conference will bring together delegates from all over the world. (Source: EurekAlert! - Biology)

Survival of the healthiest

EurekAlert! - Cancer — Wed, 04 Nov 2009 05:00:00 +0100

(BioMed Central) The ultimate goal in cancer research, a treatment that kills cancer cells whilst leaving healthy cells untouched, is brought nearer by the success of a new therapeutic approach. The potential therapy, published in BioMed Central's open access journal Breast Cancer Research, targets proliferation of cancer, but not normal, cells. (Source: EurekAlert! - Cancer)

Radiation therapy after lumpectomy for breast cancer can be safely reduced to 4 weeks

EurekAlert! - Cancer — Wed, 04 Nov 2009 05:00:00 +0100

(Fox Chase Cancer Center) Researchers at Fox Chase Cancer Center found that radiation treatment for women who had a lumpectomy for early-stage breast cancer can be safely reduced to four weeks, instead of the usual six to seven weeks, by delivering a higher daily dose -- greatly reducing the length of treatment time. The five-year results of the phase II study will be presented today at the annual meeting of the American Society for Radiation Oncology. (Source: EurekAlert! - Cancer)

The role of clusterin (CLU) in malignant transformation and drug resistance in breast carcinomas.

Advances in Cancer Research — Wed, 04 Nov 2009 02:42:03 +0100

Authors: Redondo M, Tellez T, Roldan MJ Breast cancer is the main cause of cancer-related death among women in Western countries. Current research is focused on identifying antiapoptotic proteins which could be a possible target for novel chemotherapeutic drugs. Secretory clusterin (sCLU) is an extracellular chaperone that has been functionally implicated in DNA repair, cell-cycle regulation, apoptotic cell death and tumorigenesis. The implication of sCLU in carcinogenesis and the progression of breast carcinomas make it an interesting gene, worthy of investigation. It has been reported to present powerful antiapoptotic activity and to perform a prosurvival function with most therapeutic treatments for breast cancer. This review summarizes our current understanding of the role of CLU i...

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Breast cancer changes with spread

BBC News | Health | UK Edition — Wed, 04 Nov 2009 01:13:11 +0100

Nearly 40% of breast cancer tumours change form when they spread, a study shows. (Source: BBC News | Health | UK Edition)

Treatment breakthrough for breast cancer

Scotsman.com News - Health — Wed, 04 Nov 2009 00:00:00 +0100

A BREAKTHROUGH by Scottish scientists could help lead to more successful treatments for women with breast cancer, research suggests. (Source: Scotsman.com News - Health)

Breast cancer: Why do some women get it but not their sisters?

OrlandoSentinel: Medical Research — Wed, 04 Nov 2009 00:00:00 +0100

Nancy Helzing had a lot in common with her sister, from hopscotch to favorite dolls -- and, eventually, breast cancer. Her sister, Karen Moore, died in 2001. Seven years later, Helzing learned she, too, had the disease that kills about 40,000 women every... (Source: OrlandoSentinel: Medical Research)

Additional, Specialized Radiation Not Necessary For Some Women After Mastectomy

Cancercompass News: Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

After mastectomy, breast cancer patients who receive radiation treatment to the lymph nodes located behind the breast bone do not live longer than those who do not receive radiation to this hard-to-treat area, according to a randomized 10-year study presented at the plenary session, November 2, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO). (Source: Cancercompass News: Breast Cancer)

Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breast

Basic and Applied Pathology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusions: PPAR[gamma] expression is related to poor prognostic factors of breast cancer. It is considered that PPAR[gamma] has evident tumor promoting properties in vivo, but receptor-independent effects of PPAR[gamma] ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPAR[gamma] is required. (Source: Basic and Applied Pathology)

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Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their compex MMP-9/NGAL in breast cancer disease

BMC Cancer — Wed, 04 Nov 2009 00:00:00 +0100

Background: Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9) is correlated with cancer disease status. We aim to evaluate the serum expression of MMP-9, NGAL and their complex (MMP-9/NGAL) during the diagnostic work-up of women with breast abnormalities and investigate their correlation with disease severity. Methods: The study included 113 women with non-palpable breast lesions undergoing vacuum-assisted breast biopsy for histological diagnosis, and 30 healthy women, which served as controls. Expression levels of MMP-9, NGAL and their complex MMP-9/NGAL were determined in peripheral blood samples with immunoenzymatic assays. Results: Wo...

Asian Oncology Summit issues consensus statements on the management of various cancers

NeLM - Oncology — Wed, 04 Nov 2009 00:00:00 +0100

Source: Lancet Oncology Area: News The Asian Oncology summit has issued consensus statements on the management of the following conditions in the context of basic, limited, enhanced, and maximum health-care resource availability: . Management of HER2-positive breast cancer in Asia . Management of the neck after chemoradiotherapy for head and neck cancers in Asia . Management of T-cell and natural-killer-cell neoplasms in Asia . First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia . Management of hepatocellular carcinoma in Asia . Management of endometrial cancer in Asia (Source: NeLM - Oncology)

Mammography Detection of Breast Cancer Affects Mortality

Modern Medicine — Wed, 04 Nov 2009 00:00:00 +0100

Detection of advanced breast cancers by mammography reduces mortality, and adding MRI to mammography can detect hidden breast cancers in high-risk women, according to two studies published online Nov. 2 in the Journal of Clinical Oncology. (Source: Modern Medicine)

Breast Cancer Linked To Smoking And Second-Hand Smoke

Cancercompass News: Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

Until recently, the evidence surrounding the link between breast cancer and tobacco smoke was inconclusive. Now, according to an international panel of experts convened by the Ontario Tobacco Research Unit (OTRU) sufficient scientific evidence exists linking second-hand smoke exposure to pre-menopausal breast cancer and active smoking to breast cancer in women of all ages. (Source: Cancercompass News: Breast Cancer)

Stuffed Acorn Squash Makes A Hearty Entree

Cancercompass News: Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

Mollie Katzen's latest cookbook urges beginners to take on her challenge with easy recipes, such as this acorn squash entree. Use plain raw almonds, not roasted or salted, Katzen writes, and don't chop them too fine. You can cook the rice and bake the acorn squash at the same time. (Source: Cancercompass News: Breast Cancer)

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Light Stews Still Hearty: Reduce Fat And Salt In Fall Soups

Cancercompass News: Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

If you're watching your weight, soup can be deceptive. What could be more harmless for lunch or a light dinner? Not so fast. Depending on the recipe, some soups are full of cream and cheese, or sometimes worse, they start with a roux. In place of cream and butter, add flavor to soup with lots of vegetables, beef broth and dried and fresh herbs. (Source: Cancercompass News: Breast Cancer)

The BT Test - A Simple Blood Test For The Early Detection Of Breast Cancer

Cancercompass News: Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

A healthy 44-year-old woman will celebrate many future birthdays thanks to the efforts of Dr. Keri Sweeten and a new blood test for breast cancer. Dr. Sweeten, a board-certified gynecologist and Fellow of the American College of Obstetricians and Gynecologists, recently incorporated the Provista Life Science BT Test (R), a blood test for the detection of breast cancer, into her patient care practice. (Source: Cancercompass News: Breast Cancer)

Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk

Cancer — Wed, 04 Nov 2009 00:00:00 +0100

Protein phosphatase 2A (PP2A) is a major cellular phosphatase and plays key regulatory roles in growth, differentiation, and apoptosis. Women who are diagnosed with benign proliferative breast disease are at increased risk for the subsequent development of breast cancer.The authors evaluated genetic variation of PP2A holoenzyme subunits for their potential contribution to breast cancer risk. A nested case-control investigation was performed on a cohort of women who had a history of benign breast disease. The women were followed for an average of 18 years, and DNA prepared from the original archival benign breast biopsy (1954-1995) was available for 450 women who were diagnosed with breast cancer on follow-up and for 890 of 900 women in a control group who were matched on race, age, and yea...

pRb loss predicts good outcome in triple negative breast cancer

MedWire News - Breast Cancer — Wed, 04 Nov 2009 00:00:00 +0100

Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to breast cancer among Hispanic and white, non-Hispanic women in the US Southwest

Breast Cancer Research and Treatment — Tue, 03 Nov 2009 21:42:36 +0100

In conclusion, the association between IGF-1 and breast cancer differed by ethnicity, while no ethnic differences were observed in IGFBP-3-associated breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0609-5Authors Dana E. Rollison, H. Lee Moffitt Cancer Center and Research Institute Division of Cancer Prevention and Control Magnolia Drive Tampa FL 33612 USAAnna R. Giuliano, H. Lee Moffitt Cancer Center and Research Institute Division of Cancer Prevention and Control Magnolia Drive Tampa FL 33612 USABetsy C. Risendal, University of Colorado School of Medicine Denver CO USACarol Sweeney, University of Utah Department of Internal Medicine Salt Lake City UT USADavid Boulware, H. Lee Moffitt Cancer Center and Research Institute Division of Cancer Preve...

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Cancer Incidence in Israeli Jewish Survivors of World War II

JNCI — Tue, 03 Nov 2009 21:01:45 +0100

Conclusions Incidence of all cancers, particularly breast and colorectal cancer, was higher among Israeli Jews who were potentially exposed to the Holocaust than among those who were not. (Source: JNCI)

Prospective Case-Control Study of Serum Mullerian Inhibiting Substance and Breast Cancer Risk

JNCI — Tue, 03 Nov 2009 21:01:45 +0100

Conclusion MIS may be a novel biomarker of increased breast cancer risk. Additional research including confirmatory epidemiological studies and mechanistic studies is needed. (Source: JNCI)

Novel Anticancer Activity of the Autocleaved Ovotransferrin against Human Colon and Breast Cancer Cells

Journal of Agricultural and Food Chemistry — Tue, 03 Nov 2009 20:55:59 +0100

Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)

ASTRO: Post-masectomy radiation does not increase survival

Health Imaging News — Tue, 03 Nov 2009 18:29:50 +0100

Breast cancer patients who receive radiation treatment after a mastectomy do not have a greater life expectancy than those who do not receive treatments, according to the results of a 10-year randomized trial presented Monday at the American Society for Radiation Oncology (ASTRO) conference in Chicago. (Source: Health Imaging News)

ASTRO: Post-masectomy radiation does not increase survival

Health Imaging News — Tue, 03 Nov 2009 18:29:50 +0100

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Court: Pfizer doesn’t have to pay $27M

bizjournals.com Health Care:Health Insurance headlines — Tue, 03 Nov 2009 17:17:02 +0100

Pfizer Inc. doesn’t have to pay more than $27 million in punitive damages to an Arkansas woman who blamed her breast cancer on the pharmaceutical giant’s menopause drugs, an appeals court ruled Monday. (Source: bizjournals.com Health Care:Health Insurance headlines)

Court: Pfizer doesn’t have to pay $27M

bizjournals.com Health Care:Biotechnology headlines — Tue, 03 Nov 2009 17:17:02 +0100

Drug Could Help Treat Small HER2-Positive Breast Tumors

MedlinePlus Health News — Tue, 03 Nov 2009 17:00:00 +0100

Researcher urges studies to determine benefits of anti-HER2 therapies Source: HealthDay Related MedlinePlus Topic: Breast Cancer (Source: MedlinePlus Health News)

Adapting Space-industry Technology To Treat Breast Cancer

ScienceDaily Headlines — Tue, 03 Nov 2009 15:47:27 +0100

Researchers are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy. The study is examining the utility of three-dimensional thermal tomography in radiation oncology. (Source: ScienceDaily Headlines)

Women Playing for T.I.M.E. raises $453K

bizjournals.com Health Care:Biotechnology headlines — Tue, 03 Nov 2009 15:36:58 +0100

Women Playing for T.I.M.E. has raised $453,000 this year for breast cancer research and programs at M. D. Anderson Cancer Center Orlando. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Women Playing for T.I.M.E. raises $453K

bizjournals.com Health Care:Hospitals headlines — Tue, 03 Nov 2009 15:36:58 +0100

Women Playing for T.I.M.E. has raised $453,000 this year for breast cancer research and programs at M. D. Anderson Cancer Center Orlando. (Source: bizjournals.com Health Care:Hospitals headlines)

In brief

BMJ Online First — Tue, 03 Nov 2009 15:30:36 +0100

(Source: BMJ Online First)

Sebelius Releases New Report on Benefits of Health...

NurseZone.com Nursing News — Tue, 03 Nov 2009 14:43:52 +0100

Oct. 28, 2009 - As Americans mark breast cancer awareness month, Secretary of Health and Human Services Kathleen Sebelius released a new report, Health Insurance Reform and Breast Cancer: Making the Health Care System Work for Women. The report details how health insurance reform will help women diagnosed with breast cancer and is available now at www.HealthReform.gov. (Source: NurseZone.com Nursing News)

Blood ABO groups and risk of breast cancer

Medical Oncology — Tue, 03 Nov 2009 14:16:36 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9346-1Authors Didem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeySercan Aksoy, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyOmer Dizdar, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyPamir Cerci, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyIbrahim Gullu, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyYavuz Ozisik, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyKadri ...

Breast Cancer On The Rise In Poor Countries

WDSU.com - Health — Tue, 03 Nov 2009 14:11:23 +0100

Women in developing countries may avoid breast cancer checks because a diagnosis could cost them their families. (Source: WDSU.com - Health)

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Treating Breast Cancer With Adapted Space-Industry Technology

Health News from Medical News Today — Tue, 03 Nov 2009 14:00:00 +0100

Researchers at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy. The study is examining the utility of three-dimensional thermal tomography in radiation oncology. (Source: Health News from Medical News Today)

Report calls for public education on screening to ensure more realistic expectations

BMJ Online First — Tue, 03 Nov 2009 13:22:29 +0100

(Source: BMJ Online First)

TNFalpha induces HIF-1alpha expression through activation of IKKbeta.

Biochemical and Biophysical Research communications — Tue, 03 Nov 2009 11:58:21 +0100

Authors: Kuo HP, Lee DF, Xia W, Wei Y, Hung MC The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways are involved in TNFalpha-mediated HIF-1alpha accumulation and activation under normoxic conditions. Here, we provide evidence showing that IkappaB kinase beta (IKKbeta) is required for HIF-1alpha regulation by TNFalpha. We found that TNFalpha enhances HIF-1alpha protein expression in various breast cancer cell lines under either normoxic or hypoxia-mimicking conditions, but has little effect on the HIF-1alpha mRNA le...

Depression and cancer risk: 24 years of follow-up of the Baltimore Epidemiologic Catchment Area sample

Cancer Causes and Control — Tue, 03 Nov 2009 11:01:42 +0100

Conclusions Results reveal a specificity to the association between depression and hormonally mediated cancers, which provides support to hypotheses about a common biological pathway between depression and cancer. Further research can build on observational studies to examine the mechanisms through which our emotions affect our health. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9449-1Authors Alden L. Gross, Johns Hopkins Bloomberg School of Public Health Department of Mental Health 798 Hampton House, 624 N. Broadway Baltimore MD 21205 USAJoseph J. Gallo, Johns Hopkins Bloomberg School of Public Health Department of Mental Health 624 N. Broadway Baltimore MD 21205 USAWilliam W. Eaton, Johns Hopkins Bloomberg School of Public Health Depart...

Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2

Breast Cancer Research and Treatment — Tue, 03 Nov 2009 10:15:42 +0100

Abstract Genetic testing for BRCA1 and BRCA2 mutations in family members of individuals with known deleterious mutations can distinguish between patients at high risk of disease and those who are not. Some studies have suggested that individuals testing negative for known familial mutations (true negatives), may still have a higher risk of breast cancer (BC) than the general population. We have examined a prospectively followed cohort of true negative women in the US. Subjects were close relatives of known BRCA1 and BRCA2 mutation carriers who had undergone genetic testing, were negative for the known familial mutation, and were unaffected at the time of genetic testing. Standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated using SEER inciden...

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The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast

Breast Cancer Research and Treatment — Tue, 03 Nov 2009 10:15:32 +0100

In conclusion, preoperative MRI in patients with ILC can reduce re-excision rates without increasing the rate of mastectomies. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0616-6Authors R. M. Mann, Radboud University Nijmegen Medical Centre Department of Radiology huispost 667, Geert Grooteplein 10 P.O. Box 9101 6500 HB Nijmegen The NetherlandsC. E. Loo, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Department of Radiology Amsterdam The NetherlandsT. Wobbes, Radboud University Nijmegen Medical Centre Department of Surgery Nijmegen The NetherlandsP. Bult, Radboud University Nijmegen Medical Centre Department of Pathology Nijmegen The NetherlandsJ. O. Barentsz, Radboud University Nijmegen Medical Centre Department of Radiology huispost 66...

CONFERENCE: Breast Cancer Symposium

WHO Maternal, Newborn and Child Health — Tue, 03 Nov 2009 08:55:00 +0100

Organizer: Harvard School of Public Health Event dates: 3-5 November 2009 Venue: Longwood Medical Area, Boston, Mass. (Source: WHO Maternal, Newborn and Child Health)

Poor Countries See Troubling Rise In Breast Cancer

WDSU.com - Health — Tue, 03 Nov 2009 08:21:58 +0100

Nurses were training women in rural Mexico to examine their breasts for cancer when one raised her hand to object. If she lost her breast, Harvard public health specialist Felicia Knaul recalls the woman saying, "My man would leave me" -- and with him, the family's income. (Source: WDSU.com - Health)

Additional, Specialized Radiation Not Necessary For Some Women After Mastectomy

Health News from Medical News Today — Tue, 03 Nov 2009 08:00:00 +0100

Early-stage, HER2-positive breast cancer

Medicineworld.org: New Article Alert — Tue, 03 Nov 2009 05:12:34 +0100

Early-stage patients with breast cancer with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, in comparison to those with early-stage disease who do not express the aggressive protein, as per a research studyled by scientists at The University of Texas M. D. Anderson Cancer Center........ (Source: Medicineworld.org: New Article Alert)

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Cancer screening practices among racially and ethnically diverse breast cancer survivors: results from the 2001 and 2003 California Health Interview Survey

Journal of Cancer Survivorship — Tue, 03 Nov 2009 05:10:12 +0100

Conclusions Even though BCS generally had higher cancer screening rates than women without a cancer history, racial/ethnic differences exist among the type of test received. Narrowing these differences is essential to lessen disparities. Implications for cancer survivors The need for screening guidelines for BCS remains a high priority. Survivors would benefit from the frequency of screening for all cancers post-treatment. Content Type Journal ArticleDOI 10.1007/s11764-009-0102-5Authors Erica S. Breslau, National Cancer Institute Behavioral Research Program, Division of Cancer Control and Population Sciences Bethesda MD USADiana D. Jeffery, National Cancer Institute Office of Cancer Survivorship, Division of Cancer Control and Population Sciences Bet...

Space-Industry Technology to Treat Breast Cancer

Medicineworld.org: New Article Alert — Tue, 03 Nov 2009 05:01:39 +0100

Scientists at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by patients with breast cancer undergoing radiation treatment. The study is examining the utility of three-dimensional thermal tomography in radiation oncology........ (Source: Medicineworld.org: New Article Alert)

Study finds it's safe to treat HER2-positive breast cancer with trastuzumab and adjuvant radiation

EurekAlert! - Medicine and Health — Tue, 03 Nov 2009 05:00:00 +0100

(Fox Chase Cancer Center) Standard adjuvant treatment for HER2-positive breast cancer patients, following primary surgery for their cancer, is trastuzumab (herceptin) -- typically used in combination with chemotherapy. However, a new study by researchers at Fox Chase Cancer Center reports that it may be safe to treat these patients with both trastuzumab and adjuvant radiation therapy. (Source: EurekAlert! - Medicine and Health)

Experimental agent reduces breast cancer metastasis to bone

EurekAlert! - Medicine and Health — Tue, 03 Nov 2009 05:00:00 +0100

(Tufts University, Health Sciences) New research finds that a protein called ROCK is over-expressed in metastatic breast cancer and that inhibiting ROCK significantly reduces metastasis to bone. The in vitro and in vivo study suggests that ROCK may be a drug therapy target for breast cancer metastasis. (Source: EurekAlert! - Medicine and Health)

Weight training boosts breast cancer survivors' body image and intimate relationship satisfaction

EurekAlert! - Social and Behavioral Science — Tue, 03 Nov 2009 05:00:00 +0100

(University of Pennsylvania School of Medicine) In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, according to new University of Pennsylvania School of Medicine research. Breast cancer survivors who lift weights regularly feel better about bodies and their appearance and are more satisfied with their intimate relationships compared with survivors who do not lift weights, according to a new study published in the journal Breast Cancer Research and Treatment. (Source: EurekAlert! - Social and Behavioral Science)

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Warning of limitations and harm of screening for diseases

Scotsman.com News - Health — Tue, 03 Nov 2009 00:00:00 +0100

SCIENTISTS are warning people to be aware of the downsides, as well as the benefits, of screening for diseases such as breast cancer. (Source: Scotsman.com News - Health)

Disrupted sleep in breast and prostate cancer patients undergoing radiation therapy: the role of coping processes

Psycho-Oncology — Tue, 03 Nov 2009 00:00:00 +0100

This study examined changes in sleep in 33 breast cancer (BC) patients and 23 prostate cancer (PC) patients during radiation therapy and over a 6-month followup. Coping processes were examined as predictors of sleep. Self-reported sleep was assessed at eight time-points before, during, and after treatment using the Medical Outcomes Study - Sleep Scale. The COPE Scale was used to assess coping processes before treatment onset. Results: Mixed effects linear modeling analyses revealed that both BC and PC patients reported the most sleep problems prior to and during the early weeks of treatment. Coping strategies predicted sleep trajectories in both groups. In particular, approach coping predicted better sleep in PC patients, whereas avoidance coping predicted worst sleep in both PC and BC pa...

Nipple Changes

About.com Breast Cancer — Tue, 03 Nov 2009 00:00:00 +0100

Nipple changes can occur in response to a lover's caress, a baby's cry, during breastfeeding, or sometimes from a medical condition. Not all nipple changes are worrisome, but knowing which are expected changes and which are signs of disease is critical to your breast health. Learn more about nipple changes here. (Source: About.com Breast Cancer)

Coffee Brims With Health Benefits, Researchers Say

Cancercompass News: Breast Cancer — Tue, 03 Nov 2009 00:00:00 +0100

Drink up, coffee lovers. Not only is coffee aromatic and delicious, it's good for you. Who says? None other than Harvard Medical School. Once considered questionable for your health, it turns out that the beloved beverage is actually healthful in moderation. That means a few cups a day. (Source: Cancercompass News: Breast Cancer)

Early menopausal hormone therapy may increase breast cancer risk

MedWire News - Breast Cancer — Tue, 03 Nov 2009 00:00:00 +0100

The timing of estrogen-progestagen menopausal hormone therapy initiation transiently modulates the risk for breast cancer, study findings indicate. (Source: MedWire News - Breast Cancer)

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Get Your Dirty, Sexy Plastic Off My Food and Water!

About.com Breast Cancer — Tue, 03 Nov 2009 00:00:00 +0100

First it was just bottled water in those bisphenol A (BPA) plastic bottles. We were told not to drink water that "smelled like plastic" or that had sat in sun-warmed bottles. They told us that the BPA in hard plastics could cause prostate and breast cancers, diabetes and heart disease, as well as reproductive problems. BPA is everywhere: baby bottles, toys, and packaging for some microwaveable foods. So now we use BPA-free bottles, toys, and nuke our food in glass containers. That's good! But what if your food is already tainted with BPA plastic? Well, next time you look into a can of beans, soup, tomatoes, or baby formula, check out the inside of the metal can. If it has a white coating on the inner surface, you may be seeing BPA right in there with your food. Now, aside from heating a c...

Breast Cancer in the Developing World: Meeting the Unforeseen Challenge to Women, Health and Equity

DF/HCC: Latest News — Mon, 02 Nov 2009 20:16:00 +0100

(Source: DF/HCC: Latest News)

Breast Cancer in the Developing World: Meeting the Unforeseen Challenge to Women, Health and Equity

DF/HCC: Latest News — Mon, 02 Nov 2009 20:15:00 +0100

(Source: DF/HCC: Latest News)

Breast Cancer in the Developing World: Meeting the Unforeseen Challenge to Women, Health and Equity

DF/HCC: Latest News — Mon, 02 Nov 2009 20:14:00 +0100

(Source: DF/HCC: Latest News)

Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006)

Cancer Causes and Control — Mon, 02 Nov 2009 18:37:00 +0100

Conclusions This is the first study to describe the objectively assessed physical activity and sedentary time of breast cancer survivors. Increasing moderate-to-vigorous and light intensity physical activity, and decreasing sedentary time, may assist with weight management and improve other metabolic health outcomes for breast cancer survivors. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9460-6Authors Brigid M. Lynch, The University of Queensland Cancer Prevention Research Centre, School of Population Health Herston Road Brisbane QLD 4006 AustraliaDavid W. Dunstan, The University of Queensland Cancer Prevention Research Centre, School of Population Health Herston Road Brisbane QLD 4006 AustraliaGenevieve N. Healy, The University of Queens...

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Stigma Part Of Breast Cancer's Grip On Poor

WDSU.com - Health — Mon, 02 Nov 2009 18:35:35 +0100

International cancer specialists meet this week to plan an assault on a troubling increase of breast cancer in developing countries. (Source: WDSU.com - Health)

In Brief

Current Problems in Surgery — Mon, 02 Nov 2009 15:37:58 +0100

Seminal advances in the diagnosis and treatment of premenopausal breast cancer (defined as breast cancer diagnosed in women 50 years of age or younger) have transformed the disease from a uniformly fatal condition to one with survival rates as high as 98%, with an emphasis on prevention, early detection, and patient- and disease-centered coordinated therapy. Central to these changes was the critical paradigm shift that occurred in the 1970s and 1980s, away from the traditional Halstedian view of surgery as the only curative modality, to a non-Halstedian approach of multimodality therapy that achieves adequate local control and maximizes systemic adjuvant therapy through prospectively developed patient- and tumor-specific treatment plans. (Source: Current Problems in Surgery)

Breast Cancer in Premenopausal Women

Current Problems in Surgery — Mon, 02 Nov 2009 15:37:58 +0100

Abigail Adams Smith (1765-1813), affectionately known as “Nabby,” was the oldest child of John and Abigail Adams. Nabby married and had 2 children, but was essentially alone when she noticed a lump in her left breast in 1810, when she was 45 years old. Although the mass appeared initially to be a “pimple,” over the next year it grew to an obvious mass with associated skin dimpling. Well-informed and educated, she wrote to her parents in February 1811, to tell them that her doctor had discovered “a cancer in my breast.” As soon as they received the letter, the Adams wrote back urging her to come to Boston for medical advice. (Source: Current Problems in Surgery)

Foreword

Current Problems in Surgery — Mon, 02 Nov 2009 15:37:57 +0100

Although there have been remarkable advances in the diagnosis and treatment of breast cancer, this disease continues to represent the leading cause of cancer death in premenopausal women. In this issue of Current Problems in Surgery, Dr. John Vetto and his colleagues at the Oregon Health & Sciences University have written a masterful overview entitled, “Breast Cancer in Premenopausal Women.” Beginning with a discussion of advances in our understanding of pathogenesis, genetics and tumor biology, the monograph provides state of the art information on screening, diagnosis, and the increasingly multidisciplinary management of this common neoplasm. (Source: Current Problems in Surgery)

Role of plastic surgery

BMJ Online First — Mon, 02 Nov 2009 15:12:31 +0100

(Source: BMJ Online First)

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The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands [LETTERS]

Genome Research — Mon, 02 Nov 2009 15:03:31 +0100

Instructive mechanisms are present for induction of DNA methylation, as shown by methylation of specific CpG islands (CGIs) by specific inducers and in specific cancers. However, instructive factors involved are poorly understood, except for involvement of low transcription and trimethylation of histone H3 lysine 27 (H3K27me3). Here, we used methylated DNA immunoprecipitation (MeDIP) combined with a CGI oligonucleotide microarray analysis, and identified 5510 and 521 genes with promoter CGIs resistant and susceptible, respectively, to DNA methylation in prostate cancer cell lines. Expression analysis revealed that the susceptible genes had low transcription in a normal prostatic epithelial cell line. Chromatin immunoprecipitation with microarray hybridization (CHiP-chip) analysis of RNA po...

FDG-PET/CT useful for initial staging of inflammatory breast cancer patients

MedWire News - Oncology — Mon, 02 Nov 2009 13:48:18 +0100

Eighteen-fluorodeoxyglucose positron emission tomography/computed tomography imaging provides invaluable information regarding nodal status or distant metastases in inflammatory breast cancer patients and should be considered for initial staging, say researchers. (Source: MedWire News - Oncology)

Mentor Capital, Inc. Rated A $5/sh Speculative Buy On Immune System Breast Cancer Treatment In FDA Phase I/II Trials

Health News from Medical News Today — Mon, 02 Nov 2009 12:00:00 +0100

Mentor Capital, Inc. (Pink Sheets: MNTR) is well poised to be a significant participant in the expanding medical sector of Cancer Immunotherapy with a $5 price objective according to Senior Securities Analyst Howard N. Stillman. That implied 165% gain over the current $1. (Source: Health News from Medical News Today)

Two Israeli women are barred from entering Egypt to attend breast cancer conference

BMJ Online First — Mon, 02 Nov 2009 11:56:57 +0100

(Source: BMJ Online First)

Phase II Study of Gemcitabine Monotherapy as a Salvage Treatment for Japanese Metastatic Breast Cancer Patients after Anthracycline and Taxane Treatment

Japanese Journal of Clinical Oncology — Mon, 02 Nov 2009 11:24:26 +0100

Conclusion Gemcitabine at 1250 mg/m2 on days 1 and 8 of a 21-day cycle was tolerable and can be a salvage treatment option for Japanese metastatic breast cancer patients previously treated with anthracyclines and taxanes. (Source: Japanese Journal of Clinical Oncology)

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Budget Impact Analysis of Chemoprevention of Breast Cancer with Tamoxifen and Raloxifene among High-risk Women in Japan

Japanese Journal of Clinical Oncology — Mon, 02 Nov 2009 11:24:26 +0100

‘Cost saving’ was suggested in our recent economic evaluation of chemoprevention of breast cancer targeting women at high risk in Japan. However, this budget impact analysis reveals that the introduction of chemoprevention appears to be not budget saving for ~20 years, whereas the level of budget impact seems affordable. (Source: Japanese Journal of Clinical Oncology)

Genetic Variation Of Enzyme Linked With Outcomes For Women Receiving Tamoxifen

ScienceDaily Headlines — Mon, 02 Nov 2009 10:00:00 +0100

Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a new study. (Source: ScienceDaily Headlines)

Thousands of women 'having unnecessary breast surgery'

the Mail online | Health — Mon, 02 Nov 2009 08:09:45 +0100

Guidance on breast cancer screening is being rewritten after a study found thousands of women were having unnecessary surgery. (Source: the Mail online | Health)

Depression symptoms and health-related quality of life among patients with metastatic breast cancer in programme of palliative cancer care.

Neoplasma — Mon, 02 Nov 2009 05:28:06 +0100

This study was local prospective and cross-sectional. It was carried at Department of Clinical Oncology and Radiation Therapy of Charles University Hospital in Hrader Králové, Czech Republic. Dates were obtained during year 2008 among 41 patients with metastatic breast cancer in programme of palliative cancer care. The mean age for all 41 subjects was 58 years old (aged 41 - 80 years old). The Czech version of Zung self-rating depression scale was performed for evaluation of depression symptoms. The Czech version of genetic EuroQol questionnaire EQ-5D was performed for evaluation of level of HRQoL. The statistical evaluation presents that mean ZSDS (Zung self-rating depression score) certifies the presence of signs of moderately depression symptoms among patients with metastatic ...

Additional, specialized radiation not necessary for some women after mastectomy

EurekAlert! - Medicine and Health — Mon, 02 Nov 2009 05:00:00 +0100

(American Society for Radiation Oncology) After mastectomy, breast cancer patients who receive radiation treatment to the lymph nodes located behind the breast bone do not live longer than those who do not receive radiation to this hard-to-treat area, according to a randomized 10-year study presented at the plenary session, Nov. 2, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO). (Source: EurekAlert! - Medicine and Health)

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Adapting space-industry technology to treat breast cancer

EurekAlert! - Medicine and Health — Mon, 02 Nov 2009 05:00:00 +0100

(Rush University Medical Center) Researchers at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy. The study is examining the utility of three-dimensional thermal tomography in radiation oncology. (Source: EurekAlert! - Medicine and Health)

Early-stage, HER2-positive breast cancer patients at increased risk of recurrence

EurekAlert! - Medicine and Health — Mon, 02 Nov 2009 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at the University of Texas M. D. Anderson Cancer Center. (Source: EurekAlert! - Medicine and Health)

Early stage, HER2-positive breast cancer patients at increased risk of recurrence

EurekAlert! - Cancer — Mon, 02 Nov 2009 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) Early stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early stage disease who do not express the aggressive protein, according to a study led by researchers at the University of Texas M. D. Anderson Cancer Center. (Source: EurekAlert! - Cancer)

Breast Cancer Prevention: Patient Decision Making and Risk Communication in the High Risk Setting

The Breast Journal — Mon, 02 Nov 2009 00:00:00 +0100

This study provides insight into the decision making process of women at high risk for breast cancer and highlights the importance of addressing patient preferences for interventions and risk perception during risk assessment and counseling consultations. (Source: The Breast Journal)

Obesity is a Risk Factor for Developing Postoperative Lymphedema in Breast Cancer Patients

The Breast Journal — Mon, 02 Nov 2009 00:00:00 +0100

Abstract: Lymphedema (LE) is a well-known postoperative complication after axillary node dissection (ALND). Although, sentinel lymph node dissection (SLND) involves more focused surgery and less disruption of the axilla, early reports show up to 13% of patients experience some symptoms of LE. The purpose of this study was to determine predictors of arm LE in our patients under going SLND with or without an ALND. One hundred and thirty-seven breast cancer patients were treated at a comprehensive cancer center. Prospective measurement of arm volume was carried every 6 months from date of diagnosis. This data base was retrospectively reviewed for tumor stage, treatment, and subjective complaints of LE. Objective LE was defined as a change greater than 200 mL compared with the control arm. Uni...

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Time to First Tumor Progression as Outcome Predictor of a Second Trasuzumab-Based Therapy beyond Progression in HER-2 Positive Metastatic Breast Cancer1

The Breast Journal — Mon, 02 Nov 2009 00:00:00 +0100

Abstract: In a previous analysis performed on a cohort of 37 HER-2 positive metastatic breast cancer (MBC) patients treated with trastuzumab beyond progression, we found that a second trastuzumab-based therapy is associated with a considerable response rate and preserved time to progression as compared with a first trastuzumab-based therapy. In the present study, we extended the analysis to a total of 69 patients treated in four different italian Institutions, also trying to identify clinical predictors of sensitivity to a second trastuzumab-based therapy beyond progression. Efficacy results on the overall population confirmed that a second trastuzumab-based therapy beyond progression is an active regimen (27.5% of responses and 6.5 months of time to progression, respectively). Median time...

Patterns of Surgical Treatment for Women with Breast Cancer in Relation to Age

The Breast Journal — Mon, 02 Nov 2009 00:00:00 +0100

Abstract: Although treatment recommendations have been advocated for all women with early breast cancer regardless of age, it is generally accepted that different treatments are preferred based on the age of the patient. The aim of this study was to assess the pattern of breast cancer surgery after adjusting for other major prognostic factors in relation to patient age. Data on cancer characteristics and surgical procedures in 31,298 patients with early breast cancer reported to the National Breast Cancer Audit between 1999 and 2006 were used for the study. There was a close association between age and surgical treatment pattern after adjusting for other prognostic factors, including tumor size, histologic grade, number of tumors, lymph node positivity, lymphovascular invasion (LVI), and e...

Why Mammo not US

About.com Breast Cancer — Mon, 02 Nov 2009 00:00:00 +0100

Why don't doctors ask for an annual ultrasound instead of a mammogram? A mammogram is painful and uses radiation - an ultrasound is comfortable and uses sound waves. Why do we still need mammograms? Learn more about mammograms and ultrasounds for breast cancer screening here. (Source: About.com Breast Cancer)

BCAM Life Lessons

About.com Breast Cancer — Mon, 02 Nov 2009 00:00:00 +0100

Lorene felt like she had been put into a fiery kiln when she was diagnosed with breast cancer. She was shocked, but she endured the surgeries and learned how much she appreciated her life. As a mother and wife, Lorene had good reasons to stay alive. Lorene shares her life lesson from breast cancer here. (Source: About.com Breast Cancer)