MedWorm: Breast Cancer

Study: Paxil Blocks Cancer Drug's Effects

Health News: CBSNews.com — Tue, 09 Feb 2010 15:30:06 +0100

Canadian Researchers Say Popular Drug Interferes With Breast Cancer Treatment (Source: Health News: CBSNews.com)

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Breast cancer susceptibility variants alter risks in familial disease

Journal of Medical Genetics — Tue, 09 Feb 2010 15:17:08 +0100

Conclusions This study confirms that susceptibility variants in FGFR2, TOX3 and MAP3K1 and on chromosome 8q are all associated with increased risk of cancer in individuals with a family history of breast cancer, whereas CASP8 is protective in this context. The level of risk is dependent on the strength of the family history and the presence of a BRCA1/2 mutation and contributes to the understanding of the use of these variants in clinical risk prediction. (Source: Journal of Medical Genetics)

Anti-depressant "stops" cancer drug

Nursing in Practice — Tue, 09 Feb 2010 14:54:05 +0100

Women taking paroxetine alongside tamoxifen for breast cancer are more likely to die from the disease, claims new research (Source: Nursing in Practice)

Drug "boosts breast cancer deaths"

Pharmacy Europe — Tue, 09 Feb 2010 14:10:41 +0100

Researchers say a study linking paroxetine with increased mortality for women with breast cancer has major implications for clinical practice (Source: Pharmacy Europe)

Cellular Mechanisms of the Anticancer Effects of the Lichen Compound Usnic Acid

Planta Medica — Tue, 09 Feb 2010 14:10:40 +0100

In conclusion, usnic acid had a marked inhibitory effect on growth and proliferation of two different human cancer cell lines and led to loss of mitochondrial membrane potential. Cell survival was little affected; late necrosis was seen in one of the cell lines. No difference was noted between the two enantiomers.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)

Study: Paxil Blocks Cancer Drug Effects

Health News: CBSNews.com — Tue, 09 Feb 2010 14:02:18 +0100

Canadian Researchers Say Popular Drug Interferes With Breast Cancer Treatment (Source: Health News: CBSNews.com)

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Health News of the Day

Clinical Cases and Images — Tue, 09 Feb 2010 13:01:00 +0100

is a daily summary made from the selected links I post on Twitter. It is in bullet-point format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day: Spending on health care in US is 17.3% of GDP, up from 16.2% in 2008 - largest percentage increase in 5 decades http://goo.gl/IZE4 People who drank 2 or more soft drinks a week had an 87% increased risk of pancreatic cancer http://goo.gl/DcXd Thirdhand Smoke (tobacco smoke residue) Creates Indoor Cancer Risk. Nicotine reacts with indoor air pollutant to form carcinogenic compounds called tobacco-specific nitrosamines (TSNAs) http://bit.ly/cRpb4r Mediterranean diet may help prevent dementia - CNN http://bit.ly/a9lGLb Latrepirdine (Dimebon) - oral medication developed for Alzheimer's - may ...

Antidepressant blocks tamoxifen benefit: study

CTV Health — Tue, 09 Feb 2010 12:41:26 +0100

Women prescribed tamoxifen to prevent a recurrence of breast cancer should avoid taking the antidepressant Paxil and its generic equivalents because of a potentially dangerous drug interaction, a study suggests. (Source: CTV Health)

Popular antidepressant 'cancels out' effect of breast cancer drug (The Daily Telegraph, 9 February 2010)

Society for Endocrinology — Tue, 09 Feb 2010 12:00:00 +0100

Canadian scientists have shown that taking the antidepressant paroxetine (brand name Seroxat) to relieve the side effects of the breast cancer drug Tamoxifen could result in a higher mortality when compared to those not taking paroxetine. Experts advise against any sudden decisions but recommend a review of the data to clarify the nature of the interaction. Full article (Source: Society for Endocrinology)

Following DCIS Diagnosis, Psychosicail Interventions Recommended

Dermatology News From Medical News Today — Tue, 09 Feb 2010 11:00:00 +0100

Following DCIS Diagnosis, Psychosicail Interventions Recommended

Health News from Medical News Today — Tue, 09 Feb 2010 11:00:00 +0100

A new analysis has found that women with medium or low levels of income are particularly susceptible to anxiety and depression after being diagnosed with the precancerous breast condition, ductal carcinoma in situ (DCIS). Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study suggests that women with financial hardship may benefit from psychosocial interventions that are designed to accommodate their unique needs... (Source: Health News from Medical News Today)

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Racial Disparities Persist In Diagnosis Of Advanced Breast, Colon Cancer

Breast Cancer News From Medical News Today — Tue, 09 Feb 2010 10:00:00 +0100

Racial Disparities Persist In Diagnosis Of Advanced Breast, Colon Cancer

Health News from Medical News Today — Tue, 09 Feb 2010 10:00:00 +0100

The incidence of advanced breast cancer diagnosis among black women remained 30 percent to 90 percent higher compared to white women between 1992 and 2004, according to new findings by researchers at Fred Hutchinson Cancer Research Center. In addition, the disparity in the incidence of advance colorectal cancer actually widened over this time period as rates fell among whites but increased slightly among blacks. The findings are published online in the inaugural issue of Springer's journal Hormones and Cancer, a publication of the Endocrine Society... (Source: Health News from Medical News Today)

Antidepressant linked to breast cancer deaths

Nursing Times Breaking News — Tue, 09 Feb 2010 09:51:00 +0100

Women taking a popular antidepressant alongside a breast cancer drug have a higher chance of dying from the disease, doctors have said. (Source: Nursing Times Breaking News)

Anti-depressant linked to breast cancer deaths

the Mail online | Health — Tue, 09 Feb 2010 08:42:27 +0100

Researchers have found that the anti-depressant Seroxat can interfere with tamoxifen, which is prescribed to thousands of breast cancer survivors for five years at a time. (Source: the Mail online | Health)

Possible New Approach To Treating Breast And Prostate Cancers

Health News from Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, Loyola University Stritch School of Medicine researchers are zeroing in on a workhorse protein called RSK. When activated, RSK is involved in cell survival, cell proliferation and cell enlargement. These properties contribute towards cancer progression, heart enlargement and tumors associated with a genetic disease called Carney complex. Loyola researchers have discovered that a regulatory protein binds to RSK. This regulatory protein effectively keeps RSK's activity in check... (Source: Health News from Medical News Today)

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Lower Overall Dosage Of Radiotherapy In Fewer Larger Doses As Safe For Breast Cancer Patients

Health News from Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

The chronic side-effects of radiotherapy for early breast cancer, as reported by women themselves, are not any worse when treatment is given in a lower overall dose in fewer but larger treatments according to a trial part funded by Cancer Research UK and published in the Lancet Oncology. The study was part of the 4,451 patient START 1 trials, which were co-ordinated by the Clinical Trials and Statistics Unit at The Institute of Cancer Research and funded by Cancer Research UK, the Medical Research Council and the Department of Health... (Source: Health News from Medical News Today)

Possible New Approach To Treating Breast And Prostate Cancers

Breast Cancer News From Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

Lower Overall Dosage Of Radiotherapy In Fewer Larger Doses As Safe For Breast Cancer Patients

Breast Cancer News From Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

After horrible deaths caused by medical radiation mistakes are uncovered, medical group issues (sort of) an apology

NaturalNews.com — Tue, 09 Feb 2010 07:00:00 +0100

(NaturalNews) In late January, the New York Times published a startling and groundbreaking series of reports by investigative reporter Walt Bogdanich who has uncovered case after case of people who suffered devastating consequences -- including horrendously painful, torture-like deaths -- because of medical mistakes related to radiation treatment. In response to these articles, the American Association of Physicists in Medicine (AAPM) just issued a statement saying the group and its members "deeply regret that these events have occurred, and we continue to work hard to reduce the likelihood of similar events in the future."Nowhere in the statement does the AAPM acknowledge specifically what events they are talking about -- and they do not even mention the almost incomprehensible human suff...

Interaction of serotonin reuptake inhibitors with tamoxifen

BMJ Online First — Tue, 09 Feb 2010 00:05:47 +0100

(Source: BMJ Online First)

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Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study

BMJ Online First — Tue, 09 Feb 2010 00:05:44 +0100

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen’s effectiveness by inhibiting its bioactivation by cytochrome P450 2D6... (Source: BMJ Online First)

Popular antidepressant interferes with cancer drug

Reuters: Health — Tue, 09 Feb 2010 00:04:12 +0100

WASHINGTON (Reuters) - The popular antidepressant drug Paxil may interfere with breast cancer treatments, making patients more likely to relapse and die, researchers in Canada reported on Monday. (Source: Reuters: Health)

Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer

MedlinePlus Health News — Tue, 09 Feb 2010 00:00:00 +0100

Patients should avoid taking the two drugs together, researchers say Source: HealthDay Related MedlinePlus Topics: Antidepressants, Breast Cancer, Cancer Chemotherapy (Source: MedlinePlus Health News)

The Effect of High Gravidity on the Carcinogenesis of Mammary Gland in TA2 Mice

American Journal of Reproductive Immunology — Tue, 09 Feb 2010 00:00:00 +0100

Citation Wang X, Huang C, Sun B, Gu Y, Cui Y, Zhao X, Li Y, Zhang S. The effect of high gravidity on the carcinogenesis of mammary gland in TA2 mice. Am J Reprod Immunol 2010 Spontaneous breast cancer in Tientsin Albinao 2 (TA2) mice, like human pregnancy-associated breast cancer (PABC), often occurs in pregnancy and puerperium, especially in mice with high gravidity. We hypothesized that the dysfunction of cellular immunity caused by the increase of 17[beta]-estradiol (E2) and progesterone (P) might be one of the reasons for carcinogenesis of mammary gland. We investigated the T lymphocyte subsets and the concentration of serum hormone and cytokines in cancer-bearing, pregnant or postpartum TA2 mice using flow cytometry, chemiluminescent immunoassay, and enzyme-linked immunosorbent assay ...

Pharmacokinetics and its relation to toxicity of pegylated-liposomal doxorubicin in chinese patients with breast tumours

Journal of Clinical Pharmacy and Therapeutics — Tue, 09 Feb 2010 00:00:00 +0100

Conclusions: The study confirms the different pharmacokinetic and toxicity profiles of PLD compared with non-liposomal doxorubicin. The pharmacokinetic profiles in Chinese patients with breast tumours is different from those reported for European patients with metastatic breast cancer. The correlation between toxicities, neutropenia grade and nausea and two of the pharmacokinetic parameters, AUC and Cl, may be useful for guiding the dosing of the agent. (Source: Journal of Clinical Pharmacy and Therapeutics)

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Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

BioMed Central — Tue, 09 Feb 2010 00:00:00 +0100

Conclusion: LDH-A plays an important role in Taxol resistance and inhibition of LDH-A re-sensitizes Taxol-resistant cells to Taxol. This supports that Warburg effect is a property of Taxol resistant cancer cells and may play an important role in the development of Taxol resistance. To our knowledge, this is the first report showing that the increased expression of LDH-A plays an important role in Taxol resistance of human breast cancer cells. This study provides valuable information for the future development and use of targeted therapies, such as oxamate, for the treatment of patients with Taxol-resistant breast cancer. (Source: BioMed Central)

Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal women with breast cancer

NeLM - Mental Health — Tue, 09 Feb 2010 00:00:00 +0100

Source: J Clin Oncol Area: News According to results from the neuropsychological side study of the Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial, the adjuvant use of tamoxifen is associated with a reduction in some aspects of cognitive functioning in postmenopausal patients with breast cancer, whereas exemestane does not seem to be associated with any reduction in function. The TEAM trial was a randomised study comparing the efficacy and safety of five years of adjuvant exemestane (25 mg/d) with 2.5 to 3 years of tamoxifen (20 mg/d) followed by 2 to 2.5 years of exemestane. Participants had adenocarcinoma of the breast, positive oestrogen and/or progesterone receptor status, and had undergone surgery with a curative intent. This neuropsychological sub...

SSRI and Tamoxifen Increase Mortality Risk (CME/CE)

MedPage Today Geriatrics — Mon, 08 Feb 2010 23:34:29 +0100

Overlapping use of tamoxifen and the antidepressant paroxetine (Paxil) significantly increases the risk of breast cancer mortality, data from a large cohort of breast cancer patients showed. (Source: MedPage Today Geriatrics)

Fluorescent In Situ Hybridization As a Primary Test for HER2 Status in Breast Cancer: Controversies [CORRESPONDENCE]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:41 +0100

(Source: Journal of Clinical Oncology)

Physician Preferences and Knowledge Gaps Regarding the Care of Childhood Cancer Survivors: A Mailed Survey of Pediatric Oncologists [Pediatric Oncology]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:40 +0100

Conclusion Pediatric oncologists express a range of preferences with regard to LTFU of CCS. Many appear unfamiliar with LTFU surveillance guidelines. (Source: Journal of Clinical Oncology)

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Validation of a Web-Based Predictive Nomogram for Ipsilateral Breast Tumor Recurrence After Breast Conserving Therapy [Breast Cancer]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:39 +0100

Conclusion IBTR! version 2.0 is accurate in the majority of patients with a low to moderate risk of in-breast recurrence. The nomogram still overestimates risk in a minority of patients with higher risk features. Validation in a larger prospective data set is warranted. (Source: Journal of Clinical Oncology)

Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response [Breast Cancer]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:39 +0100

Conclusion Metronomic dalCMP is safe, well tolerated, and clinically active in MBC. (Source: Journal of Clinical Oncology)

Role of Axillary Clearance After a Tumor-Positive Sentinel Node in the Administration of Adjuvant Therapy in Early Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:39 +0100

Conclusion Absence of knowledge regarding the extent of nodal involvement in the ART arm appears to have no major impact on the administration of adjuvant therapy. (Source: Journal of Clinical Oncology)

Few high-risk women in U.S. take breast cancer drug

Reuters: Health — Mon, 08 Feb 2010 22:15:29 +0100

NEW YORK (Reuters Health) - Only a small number of U.S. women at high risk of breast cancer have chosen to use the drug tamoxifen to lower that risk, according to a study published Monday. (Source: Reuters: Health)

Few High-Risk Women in U.S. Take Breast Cancer Drug

MedlinePlus Health News — Mon, 08 Feb 2010 22:15:29 +0100

Only a small number of U.S. women at high risk of breast cancer have chosen to use the drug tamoxifen to lower that risk, according to a study published Monday. Source: Reuters Health Related MedlinePlus Topics: Breast Cancer, Cancer Chemotherapy (Source: MedlinePlus Health News)

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Auburn Brings Hoops for a Good Cause

OrlandoSentinel: Medical Research — Mon, 08 Feb 2010 20:51:00 +0100

Women's Basketball Invites Fans To The 'Pink Zone' Sunday Against LSU Tigers help raise awareness of breast cancer AUBURN - The Auburn women's basketball team (12-12, 3-8 SEC) is asking fans to step into the "Pink Zone" on Sunday when it hosts LSU (15-... (Source: OrlandoSentinel: Medical Research)

Financial Woes Add Anxiety To Breast Cancer Diagnosis

MedlinePlus Health News — Mon, 08 Feb 2010 19:00:00 +0100

Low- and middle-income women might benefit from psychosocial support, researchers say Source: HealthDay Related MedlinePlus Topic: Breast Cancer (Source: MedlinePlus Health News)

Breast Cancer and Depression

MedlinePlus Health News — Mon, 08 Feb 2010 16:38:13 +0100

Source: HealthDay Related MedlinePlus Topics: Breast Cancer, Depression, Exercise and Physical Fitness, Nutrition (Source: MedlinePlus Health News)

Adjuvant radiotherapy wasteful for low-risk breast cancer

PharmacoEconomics and Outcomes News — Mon, 08 Feb 2010 16:10:21 +0100

(Source: PharmacoEconomics and Outcomes News)

Parental age at childbirth and age of menarche in the offspring

Human Reproduction — Mon, 08 Feb 2010 15:53:06 +0100

CONCLUSIONS We found no significant association between parental age and AOM, but the small sample of advance aged parents (over 30 years) limits the information we have. Future studies with a larger sample or a sample with over-representation of older parents will be of value. (Source: Human Reproduction)

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Tamoxifen Not Being Used Much for Prevention of Breast Cancer

Medscape PublicHealth Headlines — Mon, 08 Feb 2010 15:11:52 +0100

A survey in the United States shows that very few women are taking tamoxifen to prevent breast cancer, even though the drug can cut risk in half. Medscape Medical News (Source: Medscape PublicHealth Headlines)

Less radiotherapy controls tumours

Nursing in Practice — Mon, 08 Feb 2010 14:51:20 +0100

Women fighting breast cancer could be given less radiotherapy after research showed larger doses given less often were just as effective (Source: Nursing in Practice)

Radiotherapy works with less doses

Pharmacy Europe — Mon, 08 Feb 2010 14:07:36 +0100

Fewer and larger doses of breast cancer radiotherapy are just as effective in fighting the disease researchers have claimed (Source: Pharmacy Europe)

Hypofractionated radiation led to better quality of life in breast cancer

HemOncToday.com — Mon, 08 Feb 2010 13:59:00 +0100

(Source: HemOncToday.com)

Fibronectin 1 and CXCL9 candidate biomarkers for breast cancer screening

MedWire News - Oncology — Mon, 08 Feb 2010 13:48:22 +0100

Gene expression profiling has identified fibronectin 1 and chemokine ligand 9 as candidate biomarkers for breast cancer screening, French researchers report. (Source: MedWire News - Oncology)

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Big doses of radiation work best on breast tumours

the Mail online | Health — Mon, 08 Feb 2010 13:36:24 +0100

Breast cancer patients could be spared unnecessary treatments after experts discovered that fewer, larger doses of radiotherapy were just as effective in treating the disease. (Source: the Mail online | Health)

Low-Dose Radiation in Breast Cancer Gets Support (CME/CE)

MedPage Today Hematology/Oncology — Mon, 08 Feb 2010 13:13:05 +0100

About 40% of women in two large breast cancer radiotherapy trials reported being concerned about some aspect of body image over the five years following therapy, but there was little difference between those on standard therapy and low-dose regimens, researchers said. (Source: MedPage Today Hematology/Oncology)

Breast cancer tumours respond to fewer, larger does of radiotherapy

Nursing Times Breaking News — Mon, 08 Feb 2010 12:21:00 +0100

Breast cancer tumours can be kept under control with fewer, larger doses of radiotherapy, research has shown. (Source: Nursing Times Breaking News)

Few Women Take Tamoxifen To Prevent Breast Cancer

Breast Cancer News From Medical News Today — Mon, 08 Feb 2010 10:00:00 +0100

Researchers with the National Cancer Institute (NCI) have found that the prevalence of tamoxifen use for the prevention of breast cancer among women without a personal history of breast cancer is very low. Tamoxifen can reduce the risk of developing breast cancer in women who are at increased risk for developing the disease... (Source: Breast Cancer News From Medical News Today)

Few Women Take Tamoxifen To Prevent Breast Cancer

Health News from Medical News Today — Mon, 08 Feb 2010 10:00:00 +0100

Researchers with the National Cancer Institute (NCI) have found that the prevalence of tamoxifen use for the prevention of breast cancer among women without a personal history of breast cancer is very low. Tamoxifen can reduce the risk of developing breast cancer in women who are at increased risk for developing the disease. Details of this survey are published in the February issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research... (Source: Health News from Medical News Today)

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Radiotherapy For Breast Cancer: A Lower Overall Dose Given In Fewer, Larger Doses Can Result In Better Quality Of Life

Health News from Medical News Today — Mon, 08 Feb 2010 08:00:00 +0100

An article published Online First in The Lancet Oncology reports that radiotherapy for breast cancer patients given as a lower overall dose in fewer higher doses (hypofractionated) compared with the international standard treatment, does not seem to increase adverse symptoms. Also, according to the self-reported experience of patients, it does not result in worse body image. These results add to the evidence that shorter hypofractionated radiotherapy schedules do not cause more side effects in the breast... (Source: Health News from Medical News Today)

Radiotherapy For Breast Cancer: A Lower Overall Dose Given In Fewer, Larger Doses Can Result In Better Quality Of Life

Breast Cancer News From Medical News Today — Mon, 08 Feb 2010 08:00:00 +0100

An article published Online First in The Lancet Oncology reports that radiotherapy for breast cancer patients given as a lower overall dose in fewer higher doses (hypofractionated) compared with the international standard treatment, does not seem to increase adverse symptoms. Also, according to the self-reported experience of patients, it does not result in worse body image... (Source: Breast Cancer News From Medical News Today)

Few women take tamoxifen to prevent breast cancer

EurekAlert! - Social and Behavioral Science — Mon, 08 Feb 2010 05:00:00 +0100

(American Association for Cancer Research) Less than a quarter of one percent of women took tamoxifen in 2000 and 2005 to prevent breast cancer.Further research is recommended to explore explanations for the drug's low use. (Source: EurekAlert! - Social and Behavioral Science)

Few women take tamoxifen to prevent breast cancer

ScienceDaily Headlines — Mon, 08 Feb 2010 05:00:00 +0100

Less than a quarter of one percent of women took tamoxifen in 2000 and 2005 to prevent breast cancer. Further research is recommended to explore explanations for the drug's low use. (Source: ScienceDaily Headlines)

Removal of ovaries following cancer diagnosis improves survival rate

Baylor College of Medicine News — Mon, 08 Feb 2010 05:00:00 +0100

Women who have recently been diagnosed with ovarian cancer or who are at a high risk for developing the disease may benefit from having their ovaries removed, said a gynecologic oncologist at Baylor College of Medicine. “For patients with a new diagnosis of ovarian cancer, surgery significantly impacts their survival,” said Dr. Concepcion Diaz-Arrastia, director of gynecologic oncology and an assistant professor at BCM. “For high-risk women – women who have previously had breast cancer or have a family history of ovarian cancer – surgical removal of the fallopian tubes and ovaries significantly reduces her chances of developing the disease.” Ovarian cancer is cancer of the ovaries, the female organs most important during a woman’s reproductive age....

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Cancer trial opens way to easier treatment

Scotsman.com News - Health — Mon, 08 Feb 2010 00:00:00 +0100

WOMEN with breast cancer could be spared unnecessary treatments after experts discovered fewer, larger, doses were just as effective in battling the disease. (Source: Scotsman.com News - Health)

Estrogen receptor-mediated transcription in three dimensions

Breast Cancer Research — Mon, 08 Feb 2010 00:00:00 +0100

Our understanding of Estrogen Receptor (ER)-mediated transcription in breast cancer cells has evolved significantly in recent years, due to advances in genomic technologies. Genome-wide mapping experiments revealed thousands of ER binding events, but linking them to the target genes has been an ongoing struggle. A recent paper [1] describes a new technique, called ChIA-PET that can directly address these questions. ChIA-PET is an unbiased approach for simultaneously identifying all genome-wide binding events of a transcription factor and at the same time those involved in long-range chromatin loops. (Source: Breast Cancer Research)

Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole

Biopharmaceutics and Drug Disposition — Mon, 08 Feb 2010 00:00:00 +0100

The purpose of this study was to formulate a drug-in-adhesive (DIA) transdermal patch containing letrozole, a third generation aromatase inhibitor for the treatment of breast cancer, using pressure-sensitive-adhesives (PSAs) and to evaluate the percutaneous penetration and pharmacokinetics of letrozole after transdermal administration, compared with that for the oral route. The formulation factors for such a patch, including the PSAs, enhancers and amount of drug loaded were investigated. Among the tested preparations, the formulation with DURO-TAK 87-4098, Azone and propylene glycol showed the highest letrozole permeation. The pharmacokinetic characteristics of an optimized DIA patch containing letrozole were determined using rats, while orally administered letrozole in solution was used ...

Four different malignancies in one patient: a case report

BioMed Central — Mon, 08 Feb 2010 00:00:00 +0100

We report a 78-year-old women who has metachronous quadruple adenocarcinoma, includes bilateral breast cancer, ovarian cancer and retroperitoneal neuroendocrine carcinoma. The development of second cancer in cancer survivors can be expected but third or higher order malignancies are rare. (Source: BioMed Central)

The impact of breast reconstruction on the delivery of chemotherapy

Cancer — Mon, 08 Feb 2010 00:00:00 +0100

The purpose of this study was to evaluate the impact of postmastectomy breast reconstruction on the timing of chemotherapy.The authors included stage I-III breast cancer patients from 8 National Comprehensive Cancer Network institutions for whom guidelines recommended chemotherapy. Surgery type was categorized as breast-conserving surgery (BCS), mastectomy alone, mastectomy with immediate reconstruction (M + IR), or mastectomy with delayed reconstruction (M + DR). A Cox regression analysis was used to assess the association between surgery type and timing of chemotherapy initiation.Of the 3643 patients, only 5.1% received it [ge]8 weeks from surgery. In the multivariate analysis, higher stage, Caucasian and Hispanic race/ethnicity, lower body mass index, and absence of comorbid conditions ...

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Safety of concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer

NeLM - News — Mon, 08 Feb 2010 00:00:00 +0100

Source: Lancet Oncology Area: News According to results from the Phase II CO-HO-RT (Concomitant HOrmono-RadioTherapy) study, letrozole can be safely delivered concomitantly with radiotherapy, shortly after surgery for early stage breast cancer. According to the authors, preclinical studies have suggested that the aromatase inhibitor letrozole may have a radiosensitising effect. They therefore designed this trial to determine whether this effect occurs in vivo, by comparing adjuvant concomitant radiotherapy and letrozole with sequential radiotherapy and letrozole in early breast cancer. A total of 150 postmenopausal women with early-stage breast cancer were randomised to open-label treatment with concurrent radiotherapy and letrozole (n=75) or sequen...

Few Women Taking Tamoxifen to Prevent Breast Cancer

Modern Medicine — Mon, 08 Feb 2010 00:00:00 +0100

Well below 1 percent of American women without a personal history of breast cancer have been taking tamoxifen to prevent breast cancer in the past decade, according to a report in the February issue of Cancer Epidemiology, Biomarkers & Prevention. (Source: Modern Medicine)

Economic Status Linked to Anxiety, Depression in Cancer

Modern Medicine — Mon, 08 Feb 2010 00:00:00 +0100

Women with low socioeconomic status who are diagnosed with breast cancer are likely to suffer higher levels of anxiety and depression than women with medium or high socioeconomic status, according to a study published online Feb. 8 in Cancer. (Source: Modern Medicine)

Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation

Journal of Cellular Physiology — Mon, 08 Feb 2010 00:00:00 +0100

The objective of the present study was to determine how Pfn1 overexpression affects cell-cycle progression of breast cancer cells. We show that Pfn1 overexpression in MDA-MB-231 breast cancer cells causes cell-cycle arrest in G1 phase and dramatically reduced proliferation in culture. Pfn1 overexpression results in increased protein stability of p27kip1 (p27 - a major cyclin-dependent kinase inhibitor) and marked elevation in the overall cellular level of p27. Proliferation defect of Pfn1 overexpressers can be partly rescued by silencing p27 expression thus suggesting a critical role of p27 in Pfn1-induced growth inhibition of MDA-MB-231 cells. Finally, Pfn1 overexpression was found to sensitize MDA-MB-231 cells to apoptosis in response to cytotoxic stimulus thus suggesting for the first t...

Making a Difference: Joshua Caterbone uses soccer tourney in fight against cancer

OrlandoSentinel: Medical Research — Sat, 06 Feb 2010 15:57:00 +0100

CARROLLTON — Joshua Caterbone knows how cancer can devastate a family. "It's been a rough year for cancer and deaths in our family," he said. Two family members have been diagnosed with the disease — his aunt with breast cancer and his... (Source: OrlandoSentinel: Medical Research)

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Interstitial Pneumonitis after Treatment with Bevacizumab and Pegylated Liposomal Doxorubicin in a Patient with Metastatic Breast Cancer

Chemotherapy — Sat, 06 Feb 2010 13:45:50 +0100

Chemotherapy 2010;56:6970 (DOI:10.1159/000282286) (Source: Chemotherapy)

New Agent To Manage Cancer Related Effusions

Health News from Medical News Today — Sat, 06 Feb 2010 09:00:00 +0100

In the USA each year, 200,000 cancer patients suffer from a malignant pleural effusion development of excessive fluid (pleural effusion) in the chest. Several litres of such fluid can accumulate, and many patients suffer from significant breathlessness and distress. One in four patients with lung cancer, one in every three with breast cancer and most of the patients with mesothelioma will develop a malignant effusion. The current strategy is to induce a pleurodesis (seal the pleural cavity with a chemical agent so no fluid can accumulate)... (Source: Health News from Medical News Today)

Acupuncture Reduces Hot Flashes, Increases Sex Drive

Breast Cancer Chronicles — Sat, 06 Feb 2010 08:06:19 +0100

It's exciting to see a form of complementary medicine that's considered safe and is able to soothe what ails you! If you are receiving hormonal therapy, please give thought to trying acupuncture. (Source: Breast Cancer Chronicles)

IMRT for the breast: a comparison of tangential planning techniques.

Physics in Medicine and Biology — Sat, 06 Feb 2010 05:46:20 +0100

Authors: Smith W, Menon G, Wolfe N, Ploquin N, Trotter T, Pudney D Three intensity-modulated tangential beam radiotherapy plan types for breast cancer treatment were evaluated based on PTV homogeneity index (HI) and equivalent uniform dose (EUD), heart V30 and EUD, whole lung V20 and EUD, and typical planning time compared to conventional 2D plans. 20 early-stage breast cancer patients were CT-scanned in the supine position, and tangential field extent, gantry and collimator angles were chosen. Four treatment plans were created for each patient: conventional, dynamically wedged plan based on the dose distribution on the central axial slice; forward planned IMRT; surface compensated plan created using an Eclipse tool and hybrid IMRT plan combining open and inverse-optimized fields. All ...

Fish and Seafood

About.com Breast Cancer — Sat, 06 Feb 2010 00:00:00 +0100

Fish and seafood is high in omega3 fatty acids, which are very beneficial for your health. Fish is a great way to get your protein, and cut down on saturated fats and calories. Learn more about fish and omega3 fatty acids here. (Source: About.com Breast Cancer)

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Should Human Genes Be Patented? US Federal Court Hearing

Breast Cancer News From Medical News Today — Fri, 05 Feb 2010 19:00:00 +0100

This week a US federal court heard a case that may decide whether it is legal to patent human genes... (Source: Breast Cancer News From Medical News Today)

This isn't the life I dreamed of ...

Guardian Unlimited Science — Fri, 05 Feb 2010 18:30:27 +0100

Carole Jahme shines the cold light of evolutionary psychology on reader's problems. This week: depressionFeeling downtroddenFrom Linda, age 48Dear Carole, The last decade has been a pretty awful one with bad things happening one after the other. My husband had a heart attack and treble heart bypass. This was followed by his being made redundant not once but twice in a relatively short space of time, with all the consequent money worries and stress that brought. My one and only professional job ended in disaster due to bullying. After this, I vowed I would never work for anybody again because I was sick of the nastiness of some women in the workplace as well the failure of organisations to do anything about it. I have since set up a little business from home as a freelancer providing editor...

Lancet: Hypofractionated radiotherapy improves quality-of-life for breast cancer patients

Health Imaging News — Fri, 05 Feb 2010 18:21:11 +0100

Hypofractionated radiotherapy regimens for the treatment of breast cancer patients does not result in increased physical side effects in the breast or detriment to body image and is equally as effective at reducing the risk of further cancer in the breast, which can lead to better quality of life for patients, according to the results of the START study published online Feb. 8 in the Lancet Oncology. (Source: Health Imaging News)

Lancet: Hypofractionated radiotherapy improves quality-of-life for breast cancer patients

Health Imaging News — Fri, 05 Feb 2010 18:21:11 +0100

Can self-esteem, mastery and perceived stigma predict long-term adjustment in women carrying a BRCA1/2-mutation? Evidence from a multi-center study

Familial Cancer — Fri, 05 Feb 2010 18:18:55 +0100

Abstract Little is known about protective and vulnerability factors of long-term adjustment with BRCA1/2 carrier status. Specifically, the role of personal resources and perceptions of stigmatization have not been studied in the context of adjustment with hereditary breast cancer. The present study, therefore, explored associations of personal resources and stigma with cancer-specific anxiety in female BRCA1/2-carriers within a cross-sectional multi-center study. Participants (n = 237) had received carrier notification between 4 months and 8 years before data collection and experienced a low level of cancer-related anxiety on average. Younger age was associated with both higher perceptions of stigma (P = .002) and cancer-specific anxiety (P ...

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Quality of life among women recently diagnosed with invasive breast cancer: the Pathways Study

Breast Cancer Research and Treatment — Fri, 05 Feb 2010 18:17:32 +0100

We describe QOL among 950 women recently diagnosed with invasive breast cancer. Starting in January 2006, we invited women aged ≥21 years who were diagnosed with first primary invasive breast cancer within Kaiser Permanente Northern California (KPNC) to enroll in the Pathways Study, a prospective study of breast cancer survivorship. QOL was measured using the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B), along with sociodemographic and social support information. Clinical characteristics were obtained from the KPNC cancer registry and electronic medical record. We used multivariable linear regression models to identify factors associated with QOL scores calculated from the FACT-B. The mean age ± SD of the sample was 59.6 years (±11.9 yea...

Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer

Journal of Cancer Research and Clinical Oncology — Fri, 05 Feb 2010 17:53:36 +0100

Conclusions These results strongly suggest that PRL-3 expression can indicate the potential role of LNM to some extent. Increasing the risk of tumor metastasis (OR = 3.889). Our results also imply that PRL-3 might be a novel molecular marker for predicting relapse of invasive breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0786-yAuthors Ru-Tian Hao, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaXiao-Hua Zhang, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaYi-Fei Pan, The First Affiliated Hospital of Wenzhou Medical College Department of Surgical Oncology Wenzhou 325000 ChinaHai-Guang Liu, The F...

Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women

Journal of Cancer Research and Clinical Oncology — Fri, 05 Feb 2010 17:53:36 +0100

Conclusion In our study, the 399-Gln allele of XRCC1 increased significantly the risk of BC and it may act as a dominant allele [Arg/Arg vs. (Gln/Gln + Arg/Gln), OR = 4.67 (95% CI 1.65–13.23), p = 0.005]. The combination of variant alleles at codon 399 and in position −77 could affect XRCC1 protein activity, impairing genome integrity and promoting cancer occurrence. Also, the number of SNPs in several genes involved in BER and HRR mechanisms made higher the risk of sporadic BC. We can conclude that genetic variants in multiple repair pathways may have a joint or additive effect in cancer risk. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s00432-010-0791-1Authors Silvia Sterpone, Rome Tre University Department...

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity

Cancer Immunology, Immunotherapy — Fri, 05 Feb 2010 17:52:59 +0100

Abstract Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support hematopoietic recovery are sought. We previously found that a beta-glucan extract from maitake mushroom Grifola frondosa (MBG) enhanced colony forming unit-granulocyte monocyte (CFU-GM) activity of mouse bone marrow and human hematopoietic progenitor cells (HPC), stimulated G-CSF production and spared HPC from doxorubicin toxicity in vitro. This investigation assessed the effects of MBG on leukocyte recovery and granulocyte/monocyte function in vivo after dose intensive paclitaxel (Ptx) in a normal mouse. After a cumulative dose of Ptx (90–120 mg/kg) given to B6D2F1mice, daily oral MBG ...

Mood and Anxiety Disorders in Breast Cancer: An Update

Current Psychiatry Reviews — Fri, 05 Feb 2010 17:13:32 +0100

(Source: Current Psychiatry Reviews)

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The Tumor Suppressor Protein HBP1 Is a Novel c-Myc-binding Protein That Negatively Regulates c-Myc Transcriptional Activity [Gene Regulation]

Journal of Biological Chemistry — Fri, 05 Feb 2010 14:38:42 +0100

c-Myc is an important transcription factor that regulates cellular proliferation, cell growth, and differentiation. A number of transcriptional co-factors for c-Myc have been described that have binding sites within highly conserved regions of the c-Myc transactivational domain (TAD). Given the importance of the c-Myc TAD, we set out to identify new proteins that interact with this region using a yeast two-hybrid assay. HBP1 was identified in our screen as a protein that interacts with full-length c-Myc but not a c-Myc mutant lacking the TAD. HBP1 is a transcriptional repressor and has been shown to negatively regulate the cell cycle. A correlation between HBP1 under-expression and breast cancer relapse has been described, suggesting that HBP1 may be an important tumor suppressor protein. ...

Recruitment of cAMP-response Element-binding Protein and Histone Deacetylase Has Opposite Effects on Glucocorticoid Receptor Gene Transcription [Signal Transduction]

Journal of Biological Chemistry — Fri, 05 Feb 2010 14:38:37 +0100

In this study, we have identified feedback regulatory domains in the human GR gene promoter and examined the roles of GR, the cAMP-response element-binding protein (CREB), and HDAC-6 in association with promoter elements of the human GR gene. Using breast cancer T47D and HeLa-GR cells, we identify specific negative glucocorticoid-response elements in the GR gene. The feedback regulatory domains were also involved in interactions with CREB. GR-bound negative glucocorticoid-response elements recruited HDAC-6, and this was dependent on treatment with dexamethasone. Both CREB and HDAC-6 formed complexes with GR-dexamethasone. The HDAC-6 LXXLL motif between amino acids 313 and 418 made direct contact with the GR AF-1 domain. Interestingly enough, although the level of GR decreased in CREB knock...

Breast reduction does not interfere with screening mammography

MedWire News - Breast Cancer — Fri, 05 Feb 2010 13:49:47 +0100

Postoperative breast changes following reduction mammoplasty do not hinder analysis of the screening mammogram, Australian researchers report. (Source: MedWire News - Breast Cancer)

Are there sex differences in the work ability of cancer survivors? Norwegian experiences from the NOCWO study

Supportive Care in Cancer — Fri, 05 Feb 2010 08:43:28 +0100

Conclusions OCWA was significantly better in male CSs than in female CSs. Male CSs did not differ from their controls, whilst female CSs scored significantly poorer than their controls. CSs with reduced overall work ability should be identified, and their mental and physical work ability should be examined independent of sex. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-010-0820-2Authors Sævar Berg Gudbergsson, Oslo University Hospital Department of Clinical Cancer Research, The Norwegian Radium Hospital Rikshospitalet 0310 Oslo NorwaySophie D. Fosså, Oslo University Hospital Department of Clinical Cancer Research, The Norwegian Radium Hospital Rikshospitalet 0310 Oslo NorwayAlv A. Dahl, Oslo University Hospital Department of Clinical Canc...

Changes in Circulating Tumor Cell Detection in Patients with Localized Breast Cancer Before and After Surgery

Annals of Surgical Oncology — Fri, 05 Feb 2010 08:03:10 +0100

Conclusions This study provides evidence of the presence of CTCs in approximately 30% of patients with localized breast cancer both before and after surgery, with change from positive to negative and vice versa in 40% of cases. No association with the pathological variables was found, except for vascular invasion and presence of preoperative CTCs. Long-term follow-up will be required to understand the significance of these data. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0918-2Authors Maria T. Sandri, European Institute of Oncology Unit of Laboratory Medicine Via Ripamonti 435 Milan ItalyLaura Zorzino, European Institute of Oncology Unit of Laboratory Medicine Via Ripamonti 435 Milan ItalyMaria C. Cassatella, European Institute of Onco...

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Older Female Cancer Survivors Have Added Health Issues Compared To Their Counterparts

Breast Cancer News From Medical News Today — Fri, 05 Feb 2010 08:00:00 +0100

As cancer survivors live longer, questions arise about what kind of care long-term survivors require. A recently published study from Case Western Reserve University's Mandel School of Applied Social Sciences found 245 older married women who survived cancer had more health problems as compared to a sample of 245 married women without cancer... (Source: Breast Cancer News From Medical News Today)

News From The US Department Of Energy's Oak Ridge National Laboratory February 2010

Breast Cancer News From Medical News Today — Fri, 05 Feb 2010 08:00:00 +0100

HEALTH CARE - Maximizing mammography . . . . . . Mammograms could conceivably save more lives with a technology being developed by researchers at Oak Ridge National Laboratory and the University of Chicago... (Source: Breast Cancer News From Medical News Today)

Cytotoxic Effects of Bilberry Extract on MCF7-GFP-Tubulin Breast Cancer Cells

Journal of Medicinal Food — Fri, 05 Feb 2010 01:53:51 +0100

Journal of Medicinal Food , Vol. 0, No. 0. (Source: Journal of Medicinal Food)

Study Findings Broaden Understanding Of Breast Cancer And Mammographic Density

Cancercompass News: Breast Cancer — Fri, 05 Feb 2010 00:00:00 +0100

According to recent research from the United States, Mammographic density is one of the strongest predictors of breast cancer risk. Recently, it has been suggested that reactive oxygen species may influence breast cancer risk through its influence on mammographic density. (Source: Cancercompass News: Breast Cancer)

New Data From Mayo Clinic Illuminate Research In Colon Cancer

Cancercompass News: Colorectal Cancer — Fri, 05 Feb 2010 00:00:00 +0100

According to recent research from the United States, Genomics and proteomics have held out the promise of individualized medicine for the last 10 or 20 years, but clinical medicine has not yet delivered on this promise. Some cancers, such as breast cancer and some hematologic malignancies, have been at the forefront of individualized therapeutic approaches by integrating molecular biomarkers into treatment decision algorithms. (Source: Cancercompass News: Colorectal Cancer)

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Nursing clinical trial of breast self-examination education in China

International Nursing Review — Fri, 05 Feb 2010 00:00:00 +0100

Conclusion: The clinical trial showed a statistically significant increase in breast self-examination after the nursing education intervention. As no other breast cancer screening method is available in most of China, this method is best suited for the masses of people currently at risk in China. (Source: International Nursing Review)

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient-report and review of cutaneous neoplasms developing at the site of radiotherapy

Journal of Cutaneous Pathology — Fri, 05 Feb 2010 00:00:00 +0100

Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woman who developed a solitary xanthogranuloma within the field of radiotherapy following treatment of her breast cancer is reported. In addition to xanthogranuloma, other benign lesions of keratinocytes, mast cells, endothelial cells and lymphatic cells have been observed at the site of radiation treatment. Also, several malignancies, including hematopoietic cancers, sarcomas, metastatic cancers and common skin cancers, have been observed within radiation ports. A causal relation...

Fine-needle aspiration cytology as the first pathological diagnostic modality in breast lesions: A comparison with core needle biopsy

Basic and Applied Pathology — Fri, 05 Feb 2010 00:00:00 +0100

Conclusions: Our data suggest that FNAC is an accurate and reliable first line diagnostic tool for evaluation of breast lesions when compared with core biopsy. (Source: Basic and Applied Pathology)

Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence (Br J Surg 2009; 96: 1289-1294)

British Journal of Surgery — Fri, 05 Feb 2010 00:00:00 +0100

The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses should be sent electronically via the BJS website (). All letters will be reviewed and, if approved, appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

Authors' reply: Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence (Br J Surg 2009; 96: 1289-1294)

British Journal of Surgery — Fri, 05 Feb 2010 00:00:00 +0100

No Abstract. (Source: British Journal of Surgery)

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A population-based gene signature is predictive of breast cancer survival and chemoresponse.

International Journal of Oncology — Thu, 04 Feb 2010 21:22:44 +0100

This study sought to develop a prognostic scheme based on a 28-gene signature in a broad patient population, including those with advanced disease. Clinically annotated transcriptional profiles of 1,734 breast cancer patients were obtained to validate the 28-gene signature in prognostic categorization. The 28-gene signature generated significant patient stratification with regard to breast cancer disease-free survival (log-rank P<0.0001; n=1,337) and overall survival (log-rank P<0.0001; n=806) in Kaplan-Meier analyses. The gene expression signature provides refined prognosis of disease-free survival (log-rank P<0.006; Kaplan-Meier analysis) within each classic clinicopathologic factor-defined subgroup, including LN-, LN+, ER-, ER+ and tumor grade II. Furthermore, it was investigat...

Cryotreatment as a simple method for cell preparation in autologous tumor cell-based vaccination.

International Journal of Oncology — Thu, 04 Feb 2010 21:22:42 +0100

In this study, we demonstrated that a preparation containing cryotreated human breast cancer cells has the same capacity as a preparation containing irradiated human breast cancer cells to induce the activation of immune cells in vivo. The vaccine strategy proposed in this study may provide the experiment basis for the use of autologous or allogeneic breast cancer cells in the cell-based vaccine approach for the treatment of breast cancer and other types of cancer as well. PMID: 20126982 [PubMed - in process] (Source: International Journal of Oncology)

Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231.

International Journal of Oncology — Thu, 04 Feb 2010 21:22:08 +0100

Authors: Blanckaert V, Ulmann L, Mimouni V, Antol J, Brancquart L, Chénais B Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorporation i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a resu...

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:44 +0100

Abstract Rapamycin and its analogues inhibit mTOR, which leads to decreased protein synthesis and decreased cancer cell proliferation in many experimental systems. Adenosine 5′- monophosphate-activated protein kinase (AMPK) activators such as metformin have similar actions, in keeping with the TSC2/1 pathway linking activation of AMPK to inhibition of mTOR. As mTOR inhibition by rapamycin is associated with attenuation of negative feedback to IRS-1, rapamycin is known to increase activation of AKT, which may reduce its anti-neoplastic activity. We observed that metformin exposure decreases AKT activation, an action opposite to that of rapamycin. We show that metformin (but not rapamycin) exposure leads to increased phosphorylation of IRS-1 at Ser789, a site previously rep...

Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:43 +0100

Abstract Given the greatly elevated risks of contralateral breast cancer (CBC) observed in breast cancer patients who carry mutations in BRCA1 and BRCA2, it is critical to determine the effectiveness of standard adjuvant therapies in preventing CBC in mutation carriers. The WECARE study is a matched, case–control study of 708 women with CBC as cases and 1,399 women with unilateral breast cancer (UBC) as controls, including 181 BRCA1/BRCA2 mutation carriers. Interviews and medical record reviews provided detailed information on risk factors and breast cancer therapy. All study participants were screened for BRCA1 and BRCA2 mutations using denaturing high-performance liquid chromatography (DHPLC) to detect genetic variants in the coding and flanking regions of the genes. Co...

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Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:40 +0100

Abstract Large genomic rearrangements (LGR) represent substantial proportion of pathogenic mutations in the BRCA1 gene, whereas the frequency of rearrangements in the BRCA2 gene is low in many populations. We screened for LGRs in BRCA1 and BRCA2 genes by multiplex ligation-dependent probe amplification (MLPA) in 521 unrelated patients negative for BRCA1/2 point mutations selected from 655 Czech high-risk breast and/or ovarian cancer patients. Besides long range PCR, a chromosome 17-specific oligonucleotide-based array comparative genomic hybridization (aCGH) was used for accurate location of deletions. We identified 14 patients carrying 8 different LGRs in BRCA1 that accounted for 12.3% of all pathogenic BRCA1 mutations. No LGRs were detected in the BRCA2 gene. In a subgroup o...

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:39 +0100

Abstract The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been widely reported, but results were inconsistent and underpowered. To clarify the effects of MTHFR polymorphisms on the risk of breast cancer, an updated meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of breast cancer was conducted. Eligible articles were identified by search of databases including MEDLINE, PubMed, Web of Science, EMBASE and Chinese Biomedical Literature database (CBM) for the period up to January 2010. Finally, a total of 41 studies with 16,480 cases and 22,388 controls were included, all for C677T polymorphism and 20 with 12,170 cases and 15,865 controls for A1298C polym...

Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:39 +0100

Abstract Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to adjuvant tamoxifen or no adjuvant treatment. Immunohistochemical (IHC) staining included ER, PR, HER2, epidermal receptor growth factor (EGFR), vascular endothelial growth factor A (VEGF-A), and vascular endothelial growth factor receptor 2 (VEGFR2). EGFR and HER2 gene copy number was defined by fluorescence in situ hybridization (FISH). All patients were included in the ...

BRCA2 N372H polymorphism and breast cancer susceptibility: a meta-analysis involving 44,903 subjects

Breast Cancer Research and Treatment — Thu, 04 Feb 2010 18:13:39 +0100

In conclusion, this meta-analysis suggests that the BRCA2 372H allele may be a low-penetrant risk factor for developing breast cancer. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0767-5Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaKai Xue, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaJian Zhang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai Chi...

Are patients receiving enough information about healthcare rationing? A qualitative study

Journal of Medical Ethics — Thu, 04 Feb 2010 15:41:36 +0100

Discussion Clinical professionals need to understand patients' need for detailed information when it comes to rationing, and to understand that they are the main gateway for this to be provided. However, disclosure could be distressing for both patients and professionals, and thus the most sensitive and acceptable ways to make this information available requires further investigation. (Source: Journal of Medical Ethics)

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DoD Breast Cancer Predoctoral Traineeship Award

Grants.gov — Thu, 04 Feb 2010 15:15:15 +0100

Funding Opportunity Number: W81XWH-10-BCRP-PREDOC Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementGrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCFDA Number: 12.420Eligible Applicants Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Agency Name DOD-AMRAA (Source: Grants.gov)

Proteins Modified by the Lipid Peroxidation Aldehyde 9,12-Dioxo-10(E)-dodecenoic Acid in MCF7 Breast Cancer Cells

Chemical Research in Toxicology — Thu, 04 Feb 2010 14:28:14 +0100

Chemical Research in Toxicology, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Chemical Research in Toxicology)

Letrozole plus bevacizumab ‘feasible’ for metastatic breast cancer

MedWire News - Oncology — Thu, 04 Feb 2010 13:48:30 +0100

Treatment with the aromatase inhibitior letrozole plus the anti-vascular endothelial growth factor antibody bevacizumab is feasible in postmenopausal patients with hormone receptor-positive metastatic breast cancer, US research shows. (Source: MedWire News - Oncology)

Array-painting in breast cancer

Society for Endocrinology — Thu, 04 Feb 2010 12:00:00 +0100

Unger et al. describe an ambitious approach to discover radiation-induced oncogenic rearrangements in breast cancer cell lines. Several chromosomal translocations were identified and mapped, and the aberrant expression of genes participating in the rearrangements was demonstrated. Although the functional consequence of these rearrangements on mammary cell tumorigenesis needs further study, this is a valuable approach to scan the genome for potentially novel radiation-induced fusion genes. Unger et al., Endocrine-Related Cancer. DOI: 10.1677/ERC-09-0065 (Source: Society for Endocrinology)

Plasma sex hormones and breast cancer

Society for Endocrinology — Thu, 04 Feb 2010 12:00:00 +0100

This nested case-control study by Woolcott and colleagues extends the existing evidence of the association between sex hormones and breast cancer risk from mainly white study populations into a multiethnic cohort. The study confirms, for the first time, that high levels of sex hormones and low levels of sex hormone-binding globulin are associated with increased breast cancer risk in an ethnically diverse population. Woolcott et al., Endocrine-Related Cancer. DOI: 10.1677/ERC-09-0211 (Source: Society for Endocrinology)

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Prolactin Blocks Oncogene Associated With Poor Prognosis In Breast Cancer

Health News from Medical News Today — Thu, 04 Feb 2010 09:00:00 +0100

Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive. Publishing in the journal Cancer Research, the researchers discovered that prolactin, a pituitary hormone that normally stimulates breast development and milk production, in fact reduces levels of an oncogene called BCL6. The BCL6 protein has previously been shown to play a role in poorly differentiated breast cancer, which carries a poorer prognosis. According to Hallgeir Rui, M.D., Ph.D... (Source: Health News from Medical News Today)

Prolactin Blocks Oncogene Associated With Poor Prognosis In Breast Cancer

Breast Cancer News From Medical News Today — Thu, 04 Feb 2010 09:00:00 +0100

Watchful Waiting Instead of Biopsy?

Breast Cancer Chronicles — Thu, 04 Feb 2010 08:45:24 +0100

Researchers from the University of Virginia recently proposed that short-term follow-up, or "watchful waiting," be used as a reasonable alternative to invasive biopsies of palpable breast lesions (meaning, they can be felt)--if those lesions display traits typical of benign growths. (Source: Breast Cancer Chronicles)

The Role of Histone Modifications and Variants in Regulating Gene Expression in Breast Cancer

Journal of Mammary Gland Biology and Neoplasia — Thu, 04 Feb 2010 06:46:33 +0100

Abstract The role of epigenetic phenomena in cancer biology is increasingly being recognized. Here we focus on the mechanisms and enzymes involved in regulating histone methylation and acetylation, and the modulation of histone variant expression and deposition. Implications of these epigenetic marks for tumor development, progression and invasiveness are discussed with a particular emphasis on breast cancer progression. Content Type Journal ArticleDOI 10.1007/s10911-010-9167-zAuthors Mathieu Dalvai, Université de Toulouse, LBME 118 route de Narbonne 31062 Toulouse FranceKerstin Bystricky, Université de Toulouse, LBME 118 route de Narbonne 31062 Toulouse France Journal Journal of Mammary Gland Biology and NeoplasiaOnline ISSN 1573-7039Print ISSN 1083-3021 (Sourc...

Letter to the Editor: Breast Cancer in Young Women in Africa: Are There Genetic and Clinical Differences with European Ancestry Patients?

World Journal of Surgery — Thu, 04 Feb 2010 06:44:20 +0100

Content Type Journal ArticleDOI 10.1007/s00268-010-0436-1Authors Georgios Baltogiannis, University Hospital of Ioannina Department of Surgery Ioannina TK 45110 GreeceD. H. Roukos, Ioannina University School of Medicine Department of Surgery Ioannina Greece Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

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Breast pathology

BMJ Online First — Thu, 04 Feb 2010 00:10:41 +0100

(Source: BMJ Online First)

Wrap Your Hands Around A Bowl Of One Of These Hearty Soups

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Almost nothing tastes better on a cold, gray day than a piping bowl of soup. And almost nothing more easily feeds a crowd. So we asked readers to send us their favorite soup and stew recipes - - the ones they simmer on the stove when there's a chill in the air, or when they find themselves with a house full of guests. (Source: Cancercompass News: Breast Cancer)

Cranberry

About.com Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Cranberries may show up on your holiday table, in your juice glass, or on a string around your Christmas tree. They are loaded with antioxidants, and have plenty of power to kill bacteria. Did you know that extract of cranberry may kill cancer too? Learn more about cranberries. (Source: About.com Breast Cancer)

Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation

BMC Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Conclusions: CASP8 and maspin expression were reduced in breast cancer cells due to promoter methylation. Selective application of demethylating agents could offer novel therapeutic opportunities in breast cancer. (Source: BMC Cancer)

Genes Found Linked To Breast Cancer Drug Resistance Could Guide Future Treatment Choices

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Researchers at Dana-Farber Cancer Institute have discovered a gene activity signature that predicts a high risk of cancer recurrence in certain breast tumors that have been treated with commonly used chemotherapy drugs. (Source: Cancercompass News: Breast Cancer)

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Medifocus, Inc. Announces Food And Drug Administration FDA Update For Its Pivotal Phase III Clinical Trial For Treatment Of Breast Cancer: Files Response To Two Remaining Questions

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Medifocus, Inc. is pleased to announce that it has filed on January 22, 2010, its response to two (2) remaining questions with the FDA in the United States of America (USA) to obtain clearance to initiate a pivotal phase III clinical trial using the Company's Microfocus APA 1000 System for the treatment of breast cancer in the USA and worldwide. (Source: Cancercompass News: Breast Cancer)

Research Describes Breast Cancer And Treatment For Depression

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Women taking tamoxifen for the treatment or prevention of recurrence of breast cancer are likely to take antidepressants either for a psychiatric disorder or for hot flashes. Recent evidence suggested that some antidepressants inhibit the metabolism of tamoxifen to its more active metabolites by the cytochrome P450 2D6 (CYP2D6) enzyme, thereby decreasing the anticancer effect, scientists in Montreal, Canada report. (Source: Cancercompass News: Breast Cancer)

Women With Breast Cancer May Benefit From Autologous Stem Cell Transplantation

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Compared to conventional chemotherapy, autologous stem cell transplantation can extend event-free survival for breast cancer patients. Clinical trials provide proof of this for breast cancer with and without distant metastases. However, there are indications that this type of stem cell transplantation can more frequently give rise to severe complications affecting almost all organ systems. (Source: Cancercompass News: Breast Cancer)

Yale University: Women With Variants In 'Clock' Gene Have Higher Risk Of Breast Cancer

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

A Yale University-led team of researchers has demonstrated for the first time that variants in a gene responsible for regulating the body's circadian rhythm may lead to breast cancer. The study appears as an OnlineFirst publication of the journal Cancer Research. (Source: Cancercompass News: Breast Cancer)

Physical Activity Associated With Healthier Aging

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Physical activity appears to be associated with a reduced risk or slower progression of several age-related conditions as well as improvements in overall health in older age, according to a commentary and four articles published in the January 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. (Source: Cancercompass News: Breast Cancer)

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IsoRay Announces It Has Provided Seeds To Canada For Research Initiatives To Expand The Use Of Cesium-131 For New Cancer Applications

Cancercompass News: Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

IsoRay, Inc. announced that it has successfully shipped the first set of Cesium-131 brachytherapy seeds to a Canadian customer for the purpose of furthering research and development of Cesium-131 in Canada. Cesium-131 is currently approved by Health Canada for the treatment of low-risk prostate cancers and has been cleared by the US FDA for treatment of a wide variety of malignant disease (e.g. prostate, head and neck, brain, breast, lung, eye, etc.). (Source: Cancercompass News: Breast Cancer)

New Data From Mayo Clinic Illuminate Research In Colon Cancer

Cancercompass News: Colorectal Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Letrozole plus bevacizumab ‘feasible’ for metastatic breast cancer

MedWire News - Breast Cancer — Thu, 04 Feb 2010 00:00:00 +0100

Epithelial-Stromal Interaction 1 (EPSTI1) Substitutes for Peritumoral Fibroblasts in the Tumor Microenvironment.

The American Journal of Pathology — Thu, 04 Feb 2010 00:00:00 +0100

Authors: de Neergaard M, Kim J, Villadsen R, Fridriksdottir AJ, Rank F, Timmermans-Wielenga V, Langerød A, Børresen-Dale AL, Petersen OW, Rønnov-Jessen L Tumor cells can activate stroma, yet the implication of this activation in terms of reciprocal induction of gene expression in tumor cells is poorly understood. Epithelial Stromal Interaction 1 (EPSTI1) is an interferon response gene originally isolated from heterotypic recombinant cultures of human breast cancer cells and activated breast myofibroblasts. Here we describe the first immunolocalization of EPSTI1 in normal and cancerous breast tissue, and we provide evidence for a role of this molecule in the regulation of tumor cell properties and epithelial-mesenchymal transition. In general, no EPSTI1 staining was obser...

Diagnostic value of vacuum-assisted breast biopsy for breast carcinoma: a meta-analysis and systematic review

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:58:00 +0100

Abstract As mammography screening has its limitation in diagnosis in breast carcinoma, minimally invasive procedures offer a better option. We conducted a systematic review to establish the overall value of Vacuum-assisted breast biopsy (VAB) for the diagnosis of breast cancer. After a review and quality assessment of 21 studies, sensitivity, specificity and other measures of accuracy of VAB for evaluating breast lesions were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall accuracy. Underestimate rate of atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) were also calculated. The summary estimates for VAB in diagnosis of breast carcinoma were as follows: sensitivity, 0.981 (95% confidenc...

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Global breast cancer seasonality

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:58 +0100

Abstract Human breast cancer incidence has seasonal patterns that seem to vary among global populations. The aggregate monthly frequency of breast cancer diagnosis was collected and examined for 2,921,714 breast cancer cases diagnosed across 64 global regions over spans from 2 to 53 years. Breast cancer is consistently diagnosed more often in spring and fall, both in the Northern and Southern Hemispheres, regardless of presumable menopausal status (≤50, >50). This seasonality is increasingly more prominent as population distance from the equator increases and this latitude dependence is most pronounced among women living in rural areas. Moreover, the overall annual incidence (2005–2006), per 100,000 population, of breast cancer increased as the latitude of popu...

Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:58 +0100

Abstract In breast cancer, recent studies suggest that the value of HER2 for predicting response to anthracycline-based chemotherapy may be more likely related to the concomitant amplification of the TOP2A gene. Here, we study the association between HER2 or TOP2A status and response to anthracycline-based preoperative chemotherapy and explore the interaction between HER2 or TOP2A status and intense dose-dense (IDD) chemotherapy. HER2 and TOP2A gene alterations were quantified by fluorescence in situ hybridization in primary tumor core biopsies from 373 high-risk primary breast cancer patients (tumors ≥3 cm or inflammatory) that received an IDD or conventionally scheduled anthracycline-based preoperative chemotherapy. HER2 was amplified in 94/350 tumors (27%) of whi...

Population-based survival-cure analysis of ER-negative breast cancer

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:56 +0100

This study investigated the trends over time in age and stage specific population-based survival of estrogen receptor negative (ER−) breast cancer patients by examining the fraction of cured patients and the median survival time for uncured patients. Cause-specific survival data from the Surveillance, Epidemiology, and End Results program for cases diagnosed during 1992–1998 were used in mixed survival cure models to evaluate the cure fraction and the extension in survival for uncured patients. Survival trends were compared with adjuvant chemotherapy data available from an overlapping patterns-of-care study. For stage II N+ disease, the largest increase in cure fraction was 44–60% (P = 0.0257) for women aged ≥70 in contrast to a 7–8% point increase for women aged &...

Depressive symptoms among young breast cancer survivors: the importance of reproductive concerns

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:56 +0100

This study investigates whether concerns about reproduction after breast cancer treatment were associated with long-term depressive symptoms. Participants include 131 women diagnosed with early-stage breast cancer at age 40 or younger participating in the Women’s Healthy Eating and Living (WHEL) Survivorship Study. Participants were enrolled an average of 1.5 years postdiagnosis and depressive symptoms were monitored 6 times throughout the average additional 10 year follow-up period. Detailed recall of reproductive concerns after treatment was collected an average of 12 years postdiagnosis. Multilevel regression was used to evaluate whether mean long-term depressive symptoms differed as a function of reproductive concerns and significant covariates. Multilevel regres...

COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case–control studies

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:55 +0100

In conclusion, COMT Val158Met polymorphism may be a low-penetrant risk factor for breast cancer development in European population. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0759-5Authors Haixia Ding, The First Affiliated Hospital of Nanjing Medical University Department of Geriatrics 300 Guangzhou Road 210029 Nanjing ChinaYuanyuan Fu, Nanjing Medical University Dental Research Institute, School of Stomatology 210029 Nanjing ChinaWeixian Chen, The First Affiliated Hospital of Nanjing Medical University Department of Geriatrics 300 Guangzhou Road 210029 Nanjing ChinaZhanwei Wang, Nanjing Medical University Department of Epidemiology and Biostatistics 140 Hanzhong Road 210029 Nanjing China Journal Breast Cancer Research and TreatmentOnline ISSN 1573...

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Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:54 +0100

Abstract Elevated mammographic density (MD) is one of the strongest risk factors for sporadic breast cancer. Epidemiologic evidence suggests that MD is, in part, genetically determined; however, the relationship between MD and BRCA1/2 mutation status is equivocal. We compared MD in unaffected BRCA1/2 mutation carriers enrolled in the U.S. National Cancer Institute’s Clinical Genetics Branch’s Breast Imaging Study (n = 143) with women at low-to-average breast cancer risk enrolled in the same study (n = 29) or the NCI/National Naval Medical Center’s Susceptibility to Breast Cancer Study (n = 90). The latter were BRCA mutation-negative members of mutation-positive families or women with no prior breast cancer, a Pedigree Assessment Tool score &...

Information from CTC measurements for metastatic breast cancer prognosis—we should do more than selecting an “optimal cut point”

Breast Cancer Research and Treatment — Wed, 03 Feb 2010 17:57:54 +0100

Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s10549-010-0762-xAuthors T. Fehm, University of Tübingen Department of Gyn./OB Calwer Str. 7 72076 Tübingen GermanyW. Sauerbrei, University Medical Center Freiburg Institute of Medical Biometry and Informatics 79104 Freiburg Germany Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment)

Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study

Cancer Causes and Control — Wed, 03 Feb 2010 17:57:36 +0100

Conclusion For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9510-0Authors Jenny N. Poynter, University of Southern California Department of Preventive Medicine Los Angeles CA USABryan Langholz, University of Southern California Department of Preventive Medicine Los Angeles CA USAJoan Largent, University of California Department of Epidemiology Irvine CA USALene Mellemkjær, Danish Cancer Society Institute of Cancer Epidemiology Copenhagen DenmarkLeslie Bernstein, City of Hope National Medi...

PIKing the right isoform: the emergent role of the p110β subunit in breast cancer

Virchows Archiv — Wed, 03 Feb 2010 17:55:55 +0100

Abstract Class IA phosphoinositide-3’-kinases (PI3Ks) regulate many cellular processes. Despite a clear implication of PI3K in cancer, the involvement of each of its isoforms namely p110α and p110β in the development of breast cancer remains elusive. Until recently, the spotlight was given to the α subunit; however, the p110β isoform has now emerged as an interesting target as well. In order to determine the importance of both these subunits in breast cancer, we aimed to study the expression of p110α and p110β in a series of invasive breast carcinomas. We constructed tissue microarrays from 315 invasive breast carcinomas and performed immunohistochemistry for p110α and β, correlating the expression patterns with clinicopathological parameters. Furthermore, overal...

A HER2-binding Affibody molecule labelled with 68Ga for PET imaging: direct in vivo comparison with the 111In-labelled analogue

European Journal of Nuclear Medicine and Molecular Imaging — Wed, 03 Feb 2010 17:54:56 +0100

Conclusion 68Ga-ABY-002 is easy to label and provides high-contrast imaging within 2 h after injection. This makes it a promising candidate for clinical molecular imaging of HER2 expression in malignant tumours. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1367-7Authors Vladimir Tolmachev, Uppsala University Division of Biomedical Radiation Sciences, Rudbeck Laboratory 751 81 Uppsala SwedenIrina Velikyan, Uppsala University Department of Biochemistry and Organic Chemistry Uppsala SwedenMattias Sandström, Uppsala University Hospital Hospital Physics, Department of Oncology Uppsala SwedenAnna Orlova, Uppsala University Division of Biomedical Radiation Sciences, Rudbeck Laboratory 751 81 Uppsala Sweden Journal European Journal...

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Feasibility of FDG PET/CT to monitor the response of axillary lymph node metastases to neoadjuvant chemotherapy in breast cancer patients

European Journal of Nuclear Medicine and Molecular Imaging — Wed, 03 Feb 2010 17:54:56 +0100

Conclusion The high accuracy in visualizing lymph node metastases and the sufficiently high SUVmax and tumour to background ratio at baseline suggest that it is feasible to monitor the axillary response with FDG PET/CT, especially in triple-negative tumours. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1343-2Authors Marieke E. Straver, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Surgical Oncology Plesmanlaan 121 1066 CX Amsterdam The NetherlandsTjeerd S. Aukema, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Nuclear Medicine Plesmanlaan 121 1066 CX Amsterdam The NetherlandsRenato A. Valdes Olmos, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Depart...

Talking With a Patient About Anthracycline- vs Nonanthracycline-Based Chemotherapy

Clinical Care Options Oncology - Breast Cancer — Wed, 03 Feb 2010 17:08:14 +0100

CCO Virtual Presentation - Peter Ravdin, MD, PhD, discusses the differences between anthracycline and nonanthracycline chemotherapy regimens and how to best communicate these differences in treatment choices to patients with breast cancer. (Source: Clinical Care Options Oncology - Breast Cancer)

Neoadjuvant Trastuzumab for Locally Advanced Breast Cancer: NOAH Results

Medscape Internal Medicine Headlines — Wed, 03 Feb 2010 15:40:52 +0100

When should trastuzumab be started in women with either HER2-positive locally advanced breast cancer or inflammatory breast cancer? Medscape Medical News (Source: Medscape Internal Medicine Headlines)

Synchronous Ovarian Cancer in a Patient with Pleomorphic Lobular Breast Cancer: A Therapeutic Dilemma

Clinical Oncology — Wed, 03 Feb 2010 15:36:35 +0100

Sir — A 49-year-old premenopausal female patient presented with a breast lump and abdominal distention. Her personal history was unremarkable and a family history revealed ovarian cancer in her aunt and thyroid cancer in her brother. On physical examination, a 4cm mass in her right breast and an axillary fixed lymphadenopathy of 2cm were palpated and ascites was detected. Biopsy from the breast lump showed pleomorphic lobular carcinoma, grade 3, oestrogen receptor and progesterone receptor were both positive with HER2 overexpression immunohistochemically. Abdominal computed tomography revealed peritoneal carcinomatosis, ascites and a 15mm left ovarian cyst. A chest X-ray and a bone scan were normal. Diagnostic paracentesis was carried out to rule out a second intra-abdominal malignancy a...

A Study of Medical Intervention in Routine Breast Cancer Follow-up

Clinical Oncology — Wed, 03 Feb 2010 15:36:34 +0100

Conclusions: A significant number of interventions were undertaken from the clinic. A large proportion of these could be co-ordinated from primary care, if adequate guidelines are in place. However, rapid advances in breast cancer management should be considered, and cost-effectiveness needs to be studied before making strong recommendations as to where breast cancer follow-up is best managed. (Source: Clinical Oncology)

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Attitudes of Canadian Radiation Oncologists towards Post-lumpectomy Radiotherapy for Elderly Women with Stage I Hormone-responsive Breast Cancer

Clinical Oncology — Wed, 03 Feb 2010 15:36:34 +0100

Conclusions: Although there is significant variation in practice patterns and attitudes among radiation oncologists regarding post-lumpectomy radiotherapy for elderly, low-risk breast cancer patients, the vast majority value patient choice and would be willing to use a decision aid designed for this population in their practice. (Source: Clinical Oncology)

Screening for breast cancer post reduction mammoplasty

Clinical Radiology — Wed, 03 Feb 2010 15:36:28 +0100

Conclusion: Postoperative breast changes following reduction mammoplasty do not significantly hinder analysis of the screening mammogram. (Source: Clinical Radiology)

Criteria for the safe avoidance of needle sampling in young women with solid breast masses

Clinical Radiology — Wed, 03 Feb 2010 15:36:28 +0100

Conclusion: Application of the proposed criteria would spare a significant number of young women unnecessary needle sampling. (Source: Clinical Radiology)

DoD Breast Cancer Multi-Team Award

Grants.gov — Wed, 03 Feb 2010 15:15:25 +0100

Funding Opportunity Number: W81XWH-10-BCRP-MTA Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementGrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCFDA Number: 12.420Eligible Applicants Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Agency Name DOD-AMRAA (Source: Grants.gov)