MedWorm: Breast Cancer

Advances In Genetics Give Cancer Fight A Brighter Future

Cancercompass News: Breast Cancer — Sun, 21 Mar 2010 00:00:00 +0100

When the internal bleeding started, Ellen Pulhamus figured she might die soon. Then the 60- year-old Denver woman got the call she believes gave her the gift of time. A biopsy of the tumors from Pulhamus' lung cancer, which had spread to her abdomen, found a very specific rearrangement of genes inside the cancer cells. She was eligible to join a clinical trial at the University of Colorado Cancer Center, testing a drug made to target her particular gene mutation. (Source: Cancercompass News: Breast Cancer)

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Rare ATM Gene Mutations, Plus Radiation, May Increase Risk Of A Second Breast Cancer

Cancercompass News: Breast Cancer — Sun, 21 Mar 2010 00:00:00 +0100

Certain rare mutations in the ataxia telangiectasia mutated (ATM) gene, combined with radiation exposure, may increase a woman's risk of developing a second cancer in the opposite breast, according to a study published onlineMarch 19 in theJournal of the National Cancer Institute. (Source: Cancercompass News: Breast Cancer)

Freezing out breast cancer

ScienceDaily Headlines — Sat, 20 Mar 2010 15:00:00 +0100

Interventional radiologists have opened the door to an encouraging potential future treatment for the nearly 200,000 women who are diagnosed with breast cancer in the United States each year: image-guided, multiprobe cryotherapy. In the first reported study, researchers were able to successfully freeze breast cancer in patients who refused surgery; the women did not have to undergo surgery after treatment to ensure that tumors had been killed. (Source: ScienceDaily Headlines)

Tamoxifen for relapse of ovarian cancer.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: We are unable to make any evidence-based recommendations as we found no comparative studies assessing the effectiveness of tamoxifen in women with recurrent ovarian cancer. There is limited evidence on anti-tumour activity from phase 2 studies, but these contain no data on the effect of tamoxifen on symptom control, QOL or the prolongation of life. PMID: 20238312 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

NO to Breast: When, Why and Why Not?

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Pervin S, Chaudhuri G, Singh R Nitric oxide is a pleiotropic ancestral molecule, which elicits beneficial effect in many physiological settings but is also tenaciously expressed in numerous pathological conditions, particularly breast tumors. Nitric oxide is particularly harmful in adipogenic milieu of the breast, where it initiates and promotes tumorigenesis. Epidemiological studies have associated populations at a greater risk for developing breast cancer, predominantly estrogen receptor positive tumors, to express specific polymorphic forms of endothelial nitric oxide synthase, that produce sustained low levels of nitric oxide. Low sustained nitric oxide generates oxidative stress and inflammatory conditions at susceptible sites in the heterogeneous microenvironment of the ...

Advising soaps

BBC News | Health | UK Edition — Sat, 20 Mar 2010 00:08:11 +0100

'Nursing' Corrie star through breast cancer (Source: BBC News | Health | UK Edition)

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Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent

Molecular Carcinogenesis — Sat, 20 Mar 2010 00:00:00 +0100

Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the involvement of additional modifier genes and/or environmental factors. Somatic inactivating mutations in the p53 gene and genes of the p53 pathway often accompany BRCA1/2-associated tumors. Therefore, we assessed whether these genes are modifiers of penetrance. We genotyped Jewish-Ashkenazi women for functional single-nucleotide polymorphisms (SNPs) in the AKT1 (C>T rs3730358) and the PERP (C>T rs2484067) genes that affect p53-mediated apoptosis, as well as two tag-SNPs in the CHEK2 (C>T rs743184) and the ZBRK...

Estrogens, regulation of p53 and breast cancer risk: a balancing act.

Cellular and Molecular Life Sciences : CMLS — Fri, 19 Mar 2010 17:22:12 +0100

Authors: Jerry DJ, Dunphy KA, Hagen MJ The paradoxical effects of ovarian hormones in both the promotion and prevention of breast cancer have been debated for over 30 years. Genetic studies have demonstrated that ovarian hormones act through NF-kappaB to stimulate proliferation and ductal elongation, whereas the p53 tumor suppressor protein plays a central role in rendering the mammary epithelium resistant to tumorigenesis. Transcriptional profiles now suggest that ovarian hormones stimulate a constellation of genes that interact with NF-kappaB and p53 to arbitrate the competing demands for proliferation and surveillance. Genes that participate in chromatin remodeling are among the acute transcriptional responses to estrogens and progestins. These genes are proposed to initiate epigene...

Science in fiction and fact, John Burnside on Waking Up In Toytown

Guardian Unlimited Science — Fri, 19 Mar 2010 16:56:11 +0100

Two dispatches from the far frontiers of science send our panellists into orbit around such issues as "how many years will it be before we all carry our personal genomes around with us, alongside our mobiles and our wallets?" and "why hasn't ET phoned earth yet?"We hear astrophysicist Paul Davies's views on what the discovery of extra-terrestrial life would do to the religions of the world. And we consult a new book by Barack Obama's medical supremo, Francis Collins, to discover whether genomic medicine will be the saving of us, or our damnation.We also interview the poet and memoirist John Burnside about the problems that plagued his early adulthood, from alcoholism to the neurological condition of apophenia – the experience of perceiving patterns and connections in random objects.Readi...

Science in fiction and fact

Guardian Unlimited Science — Fri, 19 Mar 2010 16:56:11 +0100

Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Fri, 19 Mar 2010 15:22:22 +0100

Conclusion: We identified species not previously identified in chemotherapy patients. Our results suggest a shift to a more complex oral bacterial profile in patients undergoing cancer chemotherapy. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

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Genetics Add Little to Breast Cancer Risk Prediction (CME/CE)

MedPage Today Hematology/Oncology — Fri, 19 Mar 2010 15:13:06 +0100

The addition of genetic information only modestly improved breast cancer risk assessment in an analysis of 5,600 cases. (Source: MedPage Today Hematology/Oncology)

Understanding Radiation-Induced Vascular Disease⁎

Journal of the American College of Cardiology — Fri, 19 Mar 2010 14:00:31 +0100

Radiation injury of blood vessels was originally described more than a century ago and remains a contemporary clinical problem, despite dramatic advances in the field of radiation oncology (). Clinical studies indicate that patients who have previously undergone radiation therapy for various malignancies—such as lymphoma, breast cancer, and head and neck cancer—are at increased risk for developing vascular disease (). The consequences are significant; depending upon the study, the relative risk of suffering a clinical cardiovascular event (i.e., myocardial infarction, stroke) related to radiation therapy ranges from approximately 1.5- to 4.0-fold, and this risk is further amplified in the presence of traditional cardiovascular risk factors (). Most cardiovascular events occur >10 years...

Inner-quadrant breast cancer irradiation linked to CV mortality

MedWire News - Oncology — Fri, 19 Mar 2010 13:55:07 +0100

The risk for death from cardiovascular disease is more than doubled among patients irradiated for inner-quadrant breast cancer compared with those irradiated for outer-quadrant breast cancer, study findings indicate. (Source: MedWire News - Oncology)

Inner-quadrant breast cancer irradiation linked to CV mortality

MedWire News - Breast Cancer — Fri, 19 Mar 2010 13:55:06 +0100

Lapatinib Plus Letrozole for Postmenopausal Patients With Advanced HER2+/HR+ Breast Cancer

Medscape Hematology-Oncology Headlines — Fri, 19 Mar 2010 13:45:34 +0100

This article reviews the data supporting this chemotherapy option. Expert Review of Anticancer Therapy (Source: Medscape Hematology-Oncology Headlines)

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Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model [Genomics and Proteomics]

Journal of Biological Chemistry — Fri, 19 Mar 2010 13:36:02 +0100

Breast cancer is the most common cancer type for women in the western world. Despite decades of research, the molecular processes associated with breast cancer progression are still inadequately defined. Here, we focus on the systematic alteration of metabolism by using the state of the art metabolomic profiling techniques to investigate the changes of 157 metabolites during the progression of normal mouse mammary epithelial cells to an isogenic series of mammary tumor cell lines with increasing metastatic potentials. Our results suggest a two-step metabolic progression hypothesis during the acquisition of tumorigenic and metastatic abilities. Metabolite changes accompanying tumor progression are identified in the intracellular and secreted forms in several pathways, including glycolysis, ...

Identification and brief advice could reduce alcohol harm, survey says

BMJ Online First — Fri, 19 Mar 2010 12:25:34 +0100

(Source: BMJ Online First)

Huge Health Disparities Revealed Among Asian-Americans, Native Hawaiians, Asian Immigrants

Health News from Medical News Today — Fri, 19 Mar 2010 12:00:00 +0100

Although Asian Americans have long been portrayed as a "model minority" with few major problems, data released online in the American Journal of Public Health (AJPH) reveal that distinct groups of Asian Americans, Native Hawaiians and Pacific Islanders (AA and NHPI) differ widely in death and disease rates, including from breast cancer and other conditions such as heart disease, and stand to benefit strongly from culturally appropriate care. In the first issue of a major health journal devoted to AA and NHPI populations, data show striking disparities... (Source: Health News from Medical News Today)

Huge Health Disparities Revealed Among Asian-Americans, Native Hawaiians, Asian Immigrants

Breast Cancer News From Medical News Today — Fri, 19 Mar 2010 12:00:00 +0100

Although Asian Americans have long been portrayed as a "model minority" with few major problems, data released online in the American Journal of Public Health (AJPH) reveal that distinct groups of Asian Americans, Native Hawaiians and Pacific Islanders (AA and NHPI) differ widely in death and disease rates, including from breast cancer and other conditions such as heart disease... (Source: Breast Cancer News From Medical News Today)

Celsion Corporation Announces ThermoDox(R) Abstract Accepted For Presentation At The American Society Of Clinical Oncology 2010 Annual Meeting

Health News from Medical News Today — Fri, 19 Mar 2010 10:00:00 +0100

Celsion Corporation ( CLSN) announced that an abstract about the Phase I/II trial of ThermoDox® in Recurrent Chest Wall Cancer (RCW) has been accepted for presentation at the American Society of Clinical Oncology (ASCO) 2010 Annual Meeting. The abstract presents the background, rationale, and design of the DIGNITY study which is ongoing and evaluating ThermoDox in combination with hyperthermia in women with recurrent breast cancer on their chest wall. The ASCO Annual Meeting will be held June 4 - 8, 2010 at the McCormick Place Convention Center in Chicago, Illinois... (Source: Health News from Medical News Today)

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Cancer Prevention Institute Of California Study Of Breast Cancer In Asian American Women Reveals Rising Occurrences

Health News from Medical News Today — Fri, 19 Mar 2010 09:00:00 +0100

Research scientists from the Cancer Prevention Institute of California (CPIC) released the results of a study of breast cancer in Asian women which examined their cancer rates by ethnicity, age and immigrant status. The findings challenge the notion that breast cancer rates are uniformly low across the population of Asian women and indicate rising rates of occurrences in specific ethnic groups. CPIC scientists studied Asian populations in California, the state with the largest and most diverse Asian population in the U.S... (Source: Health News from Medical News Today)

Cancer Prevention Institute Of California Study Of Breast Cancer In Asian American Women Reveals Rising Occurrences

Breast Cancer News From Medical News Today — Fri, 19 Mar 2010 09:00:00 +0100

Research scientists from the Cancer Prevention Institute of California (CPIC) released the results of a study of breast cancer in Asian women which examined their cancer rates by ethnicity, age and immigrant status. The findings challenge the notion that breast cancer rates are uniformly low across the population of Asian women and indicate rising rates of occurrences in specific ethnic groups... (Source: Breast Cancer News From Medical News Today)

Adding Common Genetic Variants To Breast Cancer Risk Models Offers Only Small Benefit

Health News from Medical News Today — Fri, 19 Mar 2010 08:00:00 +0100

Scientists report that breast cancer risk assessment models, which predict a woman's chance of developing breast cancer, do not perform better when they include common inherited genetic variants recently linked to the disease. Therefore, recommendations for breast cancer screening or treatments will remain unchanged for most women. The study, led by investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, appears in the March 18, 2010, New England Journal of Medicine... (Source: Health News from Medical News Today)

Adding Common Genetic Variants To Breast Cancer Risk Models Offers Only Small Benefit

Breast Cancer News From Medical News Today — Fri, 19 Mar 2010 08:00:00 +0100

Mammograms cause 7,000 women to receive false positives each year in the UK

NaturalNews.com — Fri, 19 Mar 2010 07:00:00 +0100

(NaturalNews) Experts from the Nordic Cochrane Centre (NCC) in the U.K. have estimated that about 7,000 British women are improperly diagnosed for breast cancer each year because of mammography. The group is urging the National Health Service (NHS) to reevaluate its breast cancer screening program, citing a failure of mammography to properly diagnose patients.Controversy over the legitimacy of mammography has been heating up worldwide as increasing numbers of medical professionals, industry watchdogs, consumer advocates, and others are recognizing that mammography is failing to achieve what it was intended to do. Not only does it improperly detect cancer cells, but it often subjects women to needless treatments that end up causing them more harm than good.Official British mammography rheto...

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ROC analysis of CT hemodynamic in the diagnosis of breast cancer

The Chinese-German Journal of Clinical Oncology — Fri, 19 Mar 2010 06:47:09 +0100

Conclusion BF and BV among CT hemodynamic parameters have certain diagnostic value in breast cancer, but BF or BV can not yet be single index to confirm or deny the diagnosis. Content Type Journal ArticleDOI 10.1007/s10330-009-0191-7Authors Xiaodong Yuan, The 309th Hospital of PLA Department of Radiology Beijing 100091 ChinaGuokun Ao, The 309th Hospital of PLA Department of Radiology Beijing 100091 ChinaChangbin Quan, The 309th Hospital of PLA Department of Radiology Beijing 100091 ChinaJing Zhang, Tongji Hospital of Tongji University Department of Radiology Shanghai 200065 ChinaPeijun Wang, Tongji Hospital of Tongji University Department of Radiology Shanghai 200065 ChinaYuan Tian, The 309th Hospital of PLA Department of Radiology Beijing 100091 China Journal...

Your Spice Cabinet May Help Fight Breast Cancer

Breast Cancer Chronicles — Fri, 19 Mar 2010 05:50:32 +0100

Now, researchers from the University of Michigan Comprehensive Cancer Center have found several household spices that might be able to limit the growth of tumor cells. (Source: Breast Cancer Chronicles)

Asians Differ When it Comes to Rates of Disease

RWJF News Digest - Quality/Equality — Fri, 19 Mar 2010 04:00:00 +0100

Scientists for decades have lumped Asians into one homogenous group when studying conditions like breast cancer and heart disease, leading to false conclusions that don't take into account the health disparities among different nationalities, researchers now say. (Source: RWJF News Digest - Quality/Equality)

Rare ATM gene mutations, plus radiation, may increase risk of a second breast cancer

EurekAlert! - Medicine and Health — Fri, 19 Mar 2010 04:00:00 +0100

(Journal of the National Cancer Institute) Certain rare mutations in the ataxia telangiectasia mutated (ATM) gene, combined with radiation exposure, may increase a woman's risk of developing a second cancer in the opposite breast, according to a study published online March 19 in the Journal of the National Cancer Institute. (Source: EurekAlert! - Medicine and Health)

Cancer Patients Find Relief In Integrative Medicine Services

Cancercompass News: Breast Cancer — Fri, 19 Mar 2010 00:00:00 +0100

The very instant Penny Kukovec was diagnosed with breast cancer her world permanently changed. Suddenly, it felt as if her life was out of her control. She felt powerless and overwhelmed. There were so many unanswered questions. Why me? What's next? What about my family? The feelings Kukovec experienced are felt by many cancer patients following their initial diagnosis and as they pursue treatment. (Source: Cancercompass News: Breast Cancer)

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MicroRNAs and their target gene networks in breast cancer

Breast Cancer Research — Fri, 19 Mar 2010 00:00:00 +0100

MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that post-transcriptionally inhibit gene expression. Many miRNAs have been implicated in several human cancers, including breast cancer. Here we describe the association between altered miRNA signatures and breast cancer tumorigenesis and metastasis. The loss of several tumor suppressor miRNAs (miR-206, miR-17-5p, miR-125a, miR-125b, miR-200, let-7, miR-34 and miR-31) and the overexpression of certain oncogenic miRNAs (miR-21, miR-155, miR-10b, miR-373 and miR-520c) have been observed in many breast cancers. The gene networks orchestrated by these miRNAs are still largely unknown, although key targets have been identified that may contribute to the disease phenotype. Here we report how the observed perturbations in miRN...

Are estrogen receptor positive breast cancers in BRCA1 mutation carriers sporadic?

Breast Cancer Research — Fri, 19 Mar 2010 00:00:00 +0100

There is a strong association between BRCA1 mutation carrier status and estrogen receptor negative breast cancer. This has led to the idea that estrogen receptor positive breast cancers in BRCA1 mutation carriers may be incidental or sporadic in nature and not as a direct result of BRCA1 dysfunction. A recent paper in Breast Cancer Research challenges this view. (Source: Breast Cancer Research)

Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

BioMed Central — Fri, 19 Mar 2010 00:00:00 +0100

Conclusion: Polymorphisms within the IGF1 gene and related genes were associated with plasma levels of IGF1, IGFBP3 and mammographic density in this study of postmenopausal women. (Source: BioMed Central)

Breast Cancer Progression Factors Identified

Modern Medicine — Fri, 19 Mar 2010 00:00:00 +0100

Progressive disease after neoadjuvant chemotherapy for breast cancer is associated with factors ranging from race to advanced tumors, which are also linked to a response to chemotherapy, according to research published online March 15 in the Journal of Clinical Oncology. (Source: Modern Medicine)

Benefits of Case Management Seen in Breast Cancer Program

Modern Medicine — Fri, 19 Mar 2010 00:00:00 +0100

Case management for low-income women who receive free breast cancer screening and diagnostic services may reduce their time to diagnosis, according to research published online March 16 in the Archives of Internal Medicine. (Source: Modern Medicine)

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Tocotrienols activity in MCF-7 breast cancer cells: Involvement of ER[beta] signal transduction

Molecular Nutrition — Fri, 19 Mar 2010 00:00:00 +0100

In this study, we report that, in MCF-7 breast cancer cell, expressing both ER[alpha] and ER[beta], PTRF treatment increases ER[beta] nuclear translocation, as demonstrated by immunofluorescence experiments and significantly inhibits ER[alpha] expression (-458.91-fold of change) and complete disappearing of the protein from the nucleus. Moreover, PTRF treatment induces ER-dependent genes expression (macrophage inhibitory cytokine-1, early growth response-1 and Cathepsin D) which is inhibited by the ER inhibitor, ICI 182.780, and induces DNA fragmentation. Finally, cDNA-array experiments suggest that the activation of specific pathways in cells treated with [gamma]-TT with respect to [alpha]-TT. Our data suggest a novel potential molecular mechanism for TTs activity. (Source: Molecular Nutr...

Qualitative screening of phenolic compounds in olive leaf extracts by hyphenated liquid chromatography and preliminary evaluation of cytotoxic activity against human breast cancer cells.

Analytical and Bioanalytical Chemistry — Fri, 19 Mar 2010 00:00:00 +0100

Authors: Fu S, Arráez-Roman D, Segura-Carretero A, Menéndez JA, Menéndez-Gutiérrez MP, Micol V, Fernández-Gutiérrez A In this work, high-performance liquid chromatography (HPLC) coupled to electrospray time-of-flight mass spectrometry (ESI-TOF-MS) and electrospray ion trap multiple-stage tandem mass spectrometry (ESI-IT-MS(2)) has been applied to screen phenolic compounds in olive leaf extracts. The use of a small particle size C18 column (1.8 mum) provided great resolution and made separation of a lot of isomers possible. The structural characterization was based on accurate mass data obtained by ESI-TOF-MS, and the nature of fragmentation ions were further confirmed by ESI-IT-MS(2) when possible. In addition, we employed tetrazolium salt (MTT)-based assa...

Significance of Sentinel Lymph Node Micrometastases in Patients With Breast Cancer [CORRESPONDENCE]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:37 +0100

(Source: Journal of Clinical Oncology)

Micrometastases and Isolated Tumor Cells in Breast Cancer Are Indeed Associated With Poorer Outcome [CORRESPONDENCE]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:37 +0100

(Source: Journal of Clinical Oncology)

Early Diagnosis of Hereditary Breast Cancer by Magnetic Resonance Imaging: What Is Realistic? [EDITORIALS]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

(Source: Journal of Clinical Oncology)

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Lifestyle and Breast Cancer Risk: The Way Forward? [EDITORIALS]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

(Source: Journal of Clinical Oncology)

Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial [Breast Cancer]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

Conclusion In women at elevated familial risk, quality-assured MRI screening shifts the distribution of screen-detected breast cancers toward the preinvasive stage. In women undergoing quality-assured MRI annually, neither mammography, nor annual or half-yearly ultrasound or CBE will add to the cancer yield achieved by MRI alone. (Source: Journal of Clinical Oncology)

Alberta Physical Activity and Breast Cancer Prevention Trial: Sex Hormone Changes in a Year-Long Exercise Intervention Among Postmenopausal Women [Breast Cancer]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

Conclusion This trial found that previously sedentary postmenopausal women can adhere to a moderate- to vigorous-intensity exercise program that results in changes in estradiol and SHBG concentrations that are consistent with a lower risk for postmenopausal breast cancer. (Source: Journal of Clinical Oncology)

Aspirin Intake and Survival After Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

Conclusion Among women living at least 1 year after a breast cancer diagnosis, aspirin use was associated with a decreased risk of distant recurrence and breast cancer death. (Source: Journal of Clinical Oncology)

First-Line Trastuzumab Plus Epirubicin and Cyclophosphamide Therapy in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Cardiac Safety and Efficacy Data From the Herceptin, Cyclophosphamide, and Epirubicin (HERCULES) Trial [Breast Cancer]

Journal of Clinical Oncology — Thu, 18 Mar 2010 22:01:36 +0100

Conclusion The HEC regimen is a promising treatment option for patients with HER2-positive MBC. The lower incidence of DLC with HEC, compared with the historic incidence associated with trastuzumab plus doxorubicin, supports further evaluation of the regimen, especially in adjuvant or neoadjuvant settings. (Source: Journal of Clinical Oncology)

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Sentinel Node Identification Rate and Nodal Involvement in the EORTC 10981-22023 AMAROS Trial

Annals of Surgical Oncology — Thu, 18 Mar 2010 19:39:50 +0100

Conclusions With a 97% detection rate in this prospective international multicenter study, the SNB procedure is highly effective, especially when the combined method is used. Further nodal involvement in patients with micrometastases and isolated tumor cells in the sentinel node was similar—both were 18%. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0945-zAuthors Marieke E. Straver, The Netherlands Cancer Institute Department of Surgical Oncology Amsterdam The NetherlandsPhilip Meijnen, The Netherlands Cancer Institute Department of Radiation Oncology Amsterdam The NetherlandsGeertjan van Tienhoven, Academic Medical Centre Department of Radiation Oncology Amsterdam The NetherlandsCornelis J. H. van de Velde, University Medical Centre ...

Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment — Thu, 18 Mar 2010 19:32:37 +0100

Abstract In this article, inconsistency of the association of polymorphisms of fibroblast growth factor receptor 2 (FGFR2) with breast cancer is noted. Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case–control studies. The results showed that all these three polymorphisms were significantly associated with altered breast cancer risk in any model (co-dominant, dominant, or recessive model) and in stratification based on ethnicity and study design. In the subgroup analyses for postmenopausal women, significantly increased risks were found for rs1219648 and...

Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of 131I by carbamazepine in breast cancer cells

Breast Cancer Research and Treatment — Thu, 18 Mar 2010 19:32:34 +0100

In conclusion, CBZ represents another potent stimulator of atRA-induced functional NIS expression resulting in an enhanced selective killing effect of 131I in MCF-7 breast cancer cells. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0835-xAuthors Michael J. Willhauck, Ludwig-Maximilians-University, Klinikum Grosshadern Department of Internal Medicine II Marchioninistrasse 15 81377 Muenchen GermanyDennis J. O`Kane, Mayo Clinic Department of Laboratory Medicine and Pathology Rochester MN USANathalie Wunderlich, Ludwig-Maximilians-University, Klinikum Grosshadern Department of Internal Medicine II Marchioninistrasse 15 81377 Muenchen GermanyBurkhard Göke, Ludwig-Maximilians-University, Klinikum Grosshadern Department of Internal Medicine II Marchioninis...

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase

Breast Cancer Research and Treatment — Thu, 18 Mar 2010 19:32:34 +0100

Abstract AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 μM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with ...

The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation

Breast Cancer Research and Treatment — Thu, 18 Mar 2010 19:32:33 +0100

We report that it is 1280- to 6700-fold more potent than the PHSCN peptide at blocking α5β1 mediated SUM-149 PT and MDA-MB-231 human breast cancer cell invasion of naturally occurring basement membranes in vitro. Chou–Talalay analysis of these data suggested that invasion inhibition by the PHSCN dendrimer was highly synergistic. We also report that, consistent with its enhanced invasion-inhibitory potency, the PHSCN dendrimer is 700- to 1100-fold more effective than the PHSCN peptide at preventing SUM-149 PT and MDA-MB-231 extravasation in the lungs of athymic, nude mice. Our results also show that many extravasated SUM-149 PT and MDA-MB-231 cells go on to develop into metastatic colonies, and that pretreatment with the PHSCN dendrimer is more than 100-fold more effective at reduc...

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PTEN mutation spectrum in breast cancers and breast hyperplasia

Journal of Cancer Research and Clinical Oncology — Thu, 18 Mar 2010 19:27:54 +0100

Conclusions The incidence of PTEN mutations is relatively high in patients with sporadic breast cancer in the region of Yunnan, China and exists at the early stage of breast cancer development. The PTEN mutations have significant effect on the expression silencing of PTEN protein indicating the important role of PTEN mutation in carcinogenesis of breast cancers. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0781-3Authors JuLun Yang, Kunming General Hospital/Kunming Medical College Department of Pathology 212 Daguan Road Kunming 650032 Yunnan ChinaYan Ren, Kunming General Hospital/Kunming Medical College Department of Pathology 212 Daguan Road Kunming 650032 Yunnan ChinaLi Wang, Kunming General Hospital/Kunming Medical College Department o...

Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells

Virchows Archiv — Thu, 18 Mar 2010 19:27:51 +0100

Abstract Histo-blood group antigens CD173 (H2) and CD174 (Lewis Y) are known to be developmentally regulated carbohydrate antigens which are expressed to a varying degree on many human carcinomas. We hypothesized that they might represent markers of cancer-initiating cells (or cancer stem cells, CSC). In order to test this hypothesis, we examined the co-expression of CD173 and CD174 with stem cell markers CD44 and CD133 by flow cytometry analysis, immunocytochemistry, and immunohistochemistry on cell lines and tissue sections from breast cancer. In three breast cancer cell lines, the percentage of CD173+/CD44+ cells ranged from 17% to >60% and of CD174+/CD44+ from 21% to 57%. In breast cancer tissue sections from 15 patients, up to 50% of tumor cells simultaneously expres...

Prognostic and predictive value of 16p12.1 and 16q22.1 copy number changes in human breast cancer

Cancer Genetics and Cytogenetics — Thu, 18 Mar 2010 16:03:07 +0100

Abstract: The present study investigated DNA copy number changes mapping to the p and q arms of chromosome 16 in breast cancer with the goal to determine their potential in identifying breast cancer patients with poor prognosis. We identified the minimal overlapping regions on chromosome 16 that are commonly deleted and amplified in breast tumors. Fluorescence in situ hybridization was used to screen a custom-made breast carcinoma tissue microarray representing all tumor grades, in order to detect DNA copy number changes mapping to 16p12.1 and 16q22.1. We generated 16q/16p ratios for each patient and examined the correlation between DNA copy number alterations and the patients' clinical and pathological parameters. We observed lower q/p ratios in grade I invasive carcinomas, compared with ...

Maintaining Fertility in Young Women with Breast Cancer

Current Treatment Options in Oncology — Thu, 18 Mar 2010 15:40:18 +0100

Opinion statement Breast cancer effects nearly 200,000 American women each year, with 9% of these women still in their childbearing years. For this subset of future survivors, the issue of fertility may be a significant quality-of-life concern. Both the causes and treatments for infertility in young breast cancer patients must be thoroughly understood by the multidisciplinary team caring for these women in order for the caregivers to be effective advocates for their patients. Radiation, cytotoxic chemotherapy, and hormonal therapy all effect ovarian function to greater or lesser degrees, with the incidence of permanent post-treatment amenorrhea following systemic treatment for breast cancer in women age 50 or younger estimated as between 33% and 76%. The science of fertil...

Adding Common Genetic Variants to Breast Cancer Risk Models Offers Only Small Benefit

MedlinePlus Health News — Thu, 18 Mar 2010 15:36:06 +0100

Source: National Cancer Institute - Related MedlinePlus Pages: Breast Cancer, Genetic Testing (Source: MedlinePlus Health News)

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A case of metastatic esophageal tumor from breast cancer

Esophagus — Thu, 18 Mar 2010 15:10:35 +0100

Abstract A 58-year-old woman was admitted to our hospital with the complaint of dysphagia that had developed 37 months after initiation of treatment for breast cancer. Endoscopy revealed severe stenosis 32 cm from the incisors through which the endoscope could not pass. No mucosal irregularities were observed, and biopsies of the stenotic lesion were negative for malignancy. Computed tomography showed wall thickening of the midthoracic esophagus and left pleural effusion, which had increased metabolic activity as detected by 18F-fluorodeoxyglucose positron emission tomography. Cytological examination of the pleural effusion showed adenocarcinoma compatible with metastasis from a prior lobular carcinoma of the breast. Vinorelbine effectively relieved her symptoms, and the di...

Inflammation and Cancer - News on Genetics, Prognosis, and Prevention

DF/HCC: Latest News — Thu, 18 Mar 2010 15:10:14 +0100

Cancer Epidemiology Seminar SeriesWednesday, March 31st, 201012:30 1:20 p.m. Kresge 502Harvard School of Public HealthCornelia Ulrich, MS, PhDFull Member, Fred Hutchinson Cancer Research Center, Cancer Prevention ProgramDirector, National Center for Tumor Diseases (NCT) HeidelbergHead and Full Professor, Division of Preventive Oncology, German Cancer Research Center (DKFZ)Inflammation and Cancer - News on Genetics, Prognosis, and Prevention"This talk will illustrate the influence of inflammatory processes on cancer risk and prognosis, using examples from colon and breast cancer research. The potential for prevention strategies with exercise interventions will be discussed. Dr. Ulrich will provide an evaluation of genetically targeted prevention strategies for NSAIDs. (Source: DF/...

Breast Cancer Risk

MedlinePlus Health News — Thu, 18 Mar 2010 15:01:54 +0100

Source: HealthDay - Related MedlinePlus Pages: Breast Cancer, Women's Health (Source: MedlinePlus Health News)

Genomic Testing Adds Little to the Prediction of Breast Cancer Risk

Medscape Today Headlines — Thu, 18 Mar 2010 14:58:33 +0100

When 10 recently identified SNPs associated with breast cancer were added to a commonly used risk-assessment tool, performance only moderately improved. Medscape Medical News (Source: Medscape Today Headlines)

Novelos Therapeutics Discontinues Current Development Program for NOV-002 in NSCLC

Drugs.com - Pharma News — Thu, 18 Mar 2010 14:33:36 +0100

NOV-002 Phase 2 Development Continues in Breast Cancer Indication; Seeking to Build Clinical Stage Oncology Pipeline NEWTON, Mass.--(BUSINESS WIRE)--Mar 18, 2010 - Novelos Therapeutics, Inc. (OTCBB: NVLT), a biopharmaceutical company focused on the... (Source: Drugs.com - Pharma News)

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Detection and identification of potential biomarkers of breast cancer

Journal of Cancer Research and Clinical Oncology — Thu, 18 Mar 2010 14:14:03 +0100

Conclusions We have identified a set of biomarkers that could discriminate breast cancer from non-cancer controls. An efficient strategy, including SELDI-TOF-MS analysis, HPLC purification, MALDI-TOF-MS trace and LC-MS/MS identification, has been proved very successful. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0775-1Authors Yuxia Fan, Zhengzhou University Department of General Surgery, The First Affiliated Hospital Zhengzhou 450052 Henan People’s Republic of ChinaJiachen Wang, Zhengzhou University Department of General Surgery, The First Affiliated Hospital Zhengzhou 450052 Henan People’s Republic of ChinaYang Yang, Huazhong University of Science and Technology Department of Thoracic Surgery, Union Hospital, Tongji Medical College...

Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays

Springer protocols feed by Pharmacology/Toxicology — Thu, 18 Mar 2010 14:12:12 +0100

In this study, we describe a method using this technology to study the generation of alternative mRNA transcripts in breast cancer cells that differ in the levels of a particular integrin, α3β1. (Source: Springer protocols feed by Pharmacology/Toxicology)

Case managers reduce diagnostic delay following an abnormal mammogram

MedWire News - Oncology — Thu, 18 Mar 2010 13:49:55 +0100

Implementing case management to a national breast cancer screening program reduces the time to diagnosis among low-income women with an abnormal mammogram, US research shows (Source: MedWire News - Oncology)

Adding Common Genetic Variants to Breast Cancer Risk Models Offers Only Small Benefit

National Institutes of Health (NIH) News Releases — Thu, 18 Mar 2010 13:01:00 +0100

Adding Common Genetic Variants to Breast Cancer Risk Models Offers Only Small Benefit

National Institutes of Health (NIH) News Releases — Thu, 18 Mar 2010 13:01:00 +0100

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Soy foods may reduce recurrence risk in breast cancer patients

Cancer Network — Thu, 18 Mar 2010 12:00:00 +0100

Study in Asian population runs counter to previous concern that phytoestrogen in soy may increase disease risk. (Source: Cancer Network)

Available Genetic Information Adds Only Modestly to Breast Cancer Risk Predictions

Physician's First Watch current issue — Thu, 18 Mar 2010 11:34:25 +0100

(Source: Physician's First Watch current issue)

Dynamic Regulation of CD24 and the Invasive, CD44posCD24neg Phenotype in Breast Cancer Cell Lines

Medscape Today Headlines — Thu, 18 Mar 2010 11:04:28 +0100

Investigators demonstrated that noninvasive, epithelial-like CD44posCD24pos cells readily give rise to invasive, mesenchymal CD44posCD24neg progeny in vivo and in vitro. Breast Cancer Research (Source: Medscape Today Headlines)

Radiation Breakthrough Gives Breast Cancer Patients Hope In Single Dose

Health News from Medical News Today — Thu, 18 Mar 2010 11:00:00 +0100

Technology never before offered in the U.S. that allows patients to receive one dose of radiation during surgery, as opposed to the current average of six weeks, was successfully delivered to several breast cancer patients last week including the sister of the man responsible for bringing the technology from Italy... (Source: Health News from Medical News Today)

Radiation Breakthrough Gives Breast Cancer Patients Hope In Single Dose

Radiology / Nuclear Medicine News From Medical News Today — Thu, 18 Mar 2010 11:00:00 +0100

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Agendia To Play Pivotal Role In ISPY-2 Trial For Breast Cancer

Breast Cancer News From Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

Agendia To Play Pivotal Role In ISPY-2 Trial For Breast Cancer

Health News from Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

Agendia, a world leader in molecular cancer diagnostics, announced it will participate in the highly anticipated I-SPY 2 TRIAL for breast cancer, set to launch at the first of nearly twenty research sites. I-SPY 2 is an exciting and groundbreaking new clinical trial model that will help scientists quickly and efficiently test the most promising drugs in development for women with higher risk, rapidly growing breast cancers-women for whom an improvement over standard treatment could dramatically change the odds of survival... (Source: Health News from Medical News Today)

Blocking Cancer In Its Path: New Cellular Defect Discovered

Health News from Medical News Today — Thu, 18 Mar 2010 07:00:00 +0100

UCSF researchers have discovered that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility. The scientists also found that a new generation of inhibitory drugs offers promise in correcting this defect. According to the study team, this discovery has broad clinical implications in the fight against cancer and could affect treatment of lymphoma and many other forms of the disease, including prostate cancer, breast cancer, colorectal cancer, brain cancer and multiple myeloma... (Source: Health News from Medical News Today)

Virtually all kidney disease patients on dialysis have vitamin D deficiency

NaturalNews.com — Thu, 18 Mar 2010 07:00:00 +0100

(NaturalNews) Research abounds that adequate vitamin D is essential for good health (http://www.naturalnews.com/Vitamin_D.html). Unfortunately, however, millions of Americans are not getting enough of this so-called "sunshine" vitamin. Now it turns out that one group in particular is almost universally lacking in vitamin D. According to a study slated for publication in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN), kidney disease patients who have low blood protein levels and who start dialysis during the winter are at extremely high risk of being seriously deficient in vitamin D.Ishir Bhan, MD, of Massachusetts General Hospital, and his research team studied data from 908 U.S. dialysis patients in the Accelerated Mortality on Renal Replacement (ArMO...

Newer Genetic Info Adds Little to Predicting Breast Cancer

MedicineNet Cancer General — Thu, 18 Mar 2010 07:00:00 +0100

Title: Newer Genetic Info Adds Little to Predicting Breast CancerCategory: Health NewsCreated: 3/17/2010 6:10:00 PMLast Editorial Review: 3/18/2010 (Source: MedicineNet Cancer General)

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Genes don't help predict breast cancer

Health News - UPI.com — Thu, 18 Mar 2010 05:29:40 +0100

WASHINGTON, March 18 (UPI) -- The inclusion of newly discovered genetic factors modestly improved the performance of risk models for breast cancer, U.S. researchers said. (Source: Health News - UPI.com)

Studies show huge health disparities among Asian-Americans, native Hawaiians, Asian immigrants

EurekAlert! - Social and Behavioral Science — Thu, 18 Mar 2010 04:00:00 +0100

(Burness Communications) Although Asian-Americans have long been portrayed as a "model minority" with few major problems, data released online today in the American Journal of Public Health reveal that distinct groups of Asian Americans, native Hawaiians and Pacific Islanders (AA and NHPI) differ widely in death and disease rates, including from breast cancer and other conditions such as heart disease, and stand to benefit strongly from culturally appropriate care. (Source: EurekAlert! - Social and Behavioral Science)

Study seeking drugs to match each women's breast cancer tumors; 2 Illinois hospitals involved

OrlandoSentinel: Medical Research — Thu, 18 Mar 2010 01:08:00 +0100

CHICAGO (AP) — A big new nationwide study on personalizing breast cancer treatment has Illinois connections. Loyola University Medical Center and the University of Chicago are among the nearly 20 centers involved. And Abbott Labs in North Chicago... (Source: OrlandoSentinel: Medical Research)

New Weapon in Breast Cancer Battle

OrlandoSentinel: Medical Research — Thu, 18 Mar 2010 00:00:00 +0100

There's a potential new weapon in the battle against breast cancer. Researchers say super-cold gas can kill tumors, and make sure they never return. The way it works is, doctors inject through a needle the super-cold gas into a patient around the tumor.... (Source: OrlandoSentinel: Medical Research)

Effort Aims To Spike Breast Cancer With New Approach

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Many women live with breast cancer that does not respond to standard medical treatment, a condition that researchers at the Virginia G. Piper Cancer Center at Scottsdale Healthcare want to change by aggressively targeting specific genes. (Source: Cancercompass News: Breast Cancer)

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Genomic Health Announces Publication Of Study Using Oncotype DX In Node-Negative And Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Genomic Health, Inc. announced the publication of positive results from a large international study which demonstrated that the Oncotype DX breast cancer Recurrence Score (RS) result is a significant independent predictor of distant recurrence in both node-negative and node- positive, hormone receptor-positive, postmenopausal breast cancer patients who are treated with either anastrozole or tamoxifen. (Source: Cancercompass News: Breast Cancer)

Lapatinib plus capecitabine feasible for advanced HER2-positive breast cancer

MedWire News - Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Lapatinib combined with capecitabine is an active treatment option for women with advanced human epidermal growth factor receptor (HER)2-positive breast cancer, including those with progressive central nervous system disease, UK researchers report. (Source: MedWire News - Breast Cancer)

Lapatinib plus capecitabine feasible for advanced HER2-positive breast cancer

MedWire News - Oncology — Thu, 18 Mar 2010 00:00:00 +0100

Novel Clinical Trial Will Rapidly Screen Promising Drugs for Breast Cancer

UCSF Medical Center — Thu, 18 Mar 2010 00:00:00 +0100

A unique national clinical trial for breast cancer — novel in its design, collaborative scope, and ability to serve as a prototype for many other diseases — gets underway this week at UCSF. (Source: UCSF Medical Center)

Optimization of preventive health care facility locations

International Journal of Health Geographics — Thu, 18 Mar 2010 00:00:00 +0100

Conclusions: Experiments based on a real application for the Alberta breast cancer screening program show that our work can increase the accessibility of breast cancer screening services in the province. (Source: International Journal of Health Geographics)

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Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells

Journal of Cellular Physiology — Thu, 18 Mar 2010 00:00:00 +0100

The cyclin-dependent kinase inhibitor protein p21Waf1/Cip1 is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21Waf1/Cip1 gene. Estradiol induces p21Waf1/Cip1 mRNA expression within 30-60 min independent of new protein synthesis in the estrogen receptor [alpha] (ER[alpha]) positive human breast cancer cell line MCF-7. Similar to other estradiol responsive promoters, the p21Waf1/Cip1 upstream promoter region has several estrogen response element (ERE) half-sites nestled in AP-1 binding sites, which are positioned upstream to Sp1 binding sites. Using the chromatin immunoprecipitation (ChIP) assay, we show that estradiol stimulation resulted in the recruitment of transcription factors ER[alpha], Sp1, and Sp3 to the p21Waf1/Cip1 upstream promoter element. The Sp1 ...

Pharmacogenetics of Target Genes Across Doxorubicin Disposition Pathway: A Review.

Current Drug Metabolism — Thu, 18 Mar 2010 00:00:00 +0100

Authors: Lal S, Mahajan A, Chen WN, Chowbay B Increased understanding of the molecular mechanisms of tumor heterogeneity combined with rapid advances in the field of pharmacogenetics and pharmacogenomics have fuelled studies on individualizing anticancer therapy. Doxorubicin (Adriamycin), is an anthracycline glycoside antibiotic originally produced by Streptomyces peucetius var. caesius, and is widely used either as a single agent or in combination with other chemotherapeutic regimens for curative, adjuvant, and palliative treatment in cancer patients. The pharmacogenetics of doxorubicin has not been well characterized. The polygenic influence of functional candidate gene variants across doxorubicin biochemical pathway is hypothesized to contribute to its heterogeneity in disposition, ...

Research From BioTechnology Institute Provide New Insights Into Breast Cancer Risk Factors

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

New research, 'Pregnancy and lactation after breast cancer elevate plasma prolactin, do not shorten and may prolong survival,' is the subject of a report. According to a study from Israel, The affliction of breast cancer is doubled for young patients wishing to have a child. Because estrogens can cause breast cancer and its elevation during pregnancy, clinical advice historically restricted pregnancy to at least 5 years post-diagnosis. (Source: Cancercompass News: Breast Cancer)

Research From Fred Hutchinson Cancer Research Center In The Area Of Breast Cancer Prevention Published

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Fresh data on breast cancer are presented in the report 'Migraine history and breast cancer risk among postmenopausal women.' Both migraine and breast cancer are hormonally mediated. Two recent reports indicate that women with a migraine history may have a lower risk of postmenopausal breast cancer than those who never suffered migraines, scientists in the United States report. (Source: Cancercompass News: Breast Cancer)

Papaya Extract Thwarts Growth Of Cancer Cells In Lab Tests

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

The humble papaya is gaining credibility in Western medicine for anticancer powers that folk cultures have recognized for generations. University of Florida researcher Nam Dang, M.D., Ph.D., and colleagues in Japan have documented papaya's dramatic anticancer effect against a broad range of lab-grown tumors, including cancers of the cervix, breast, liver, lung and pancreas. (Source: Cancercompass News: Breast Cancer)

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Acupuncture May Relieve Joint Pain Caused By Some Breast Cancer Treatments

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

A new study, led by researchers at the Herbert Irving Comprehensive Cancer Center at NewYork- Presbyterian Hospital/Columbia University Medical Center, demonstrates that acupuncture may be an effective therapy for joint pain and stiffness in breast cancer patients who are being treated with commonly used hormonal therapies. Results were published in the Journal of Clinical Oncology. (Source: Cancercompass News: Breast Cancer)

Newly Published Data Shows Chronix Biomedical's Serum DNA Assays Can Detect Early-Stage Breast Cancer

Cancercompass News: Breast Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Chronix Biomedical announced publication of a study that supports the utility of its serum DNA blood tests for the early and accurate detection of breast cancer. The Chronix tests detect the circulating DNA that is released into the blood stream by damaged and dying cells. (Source: Cancercompass News: Breast Cancer)

Breast cancer drugs get faster screening

CBC | Health — Wed, 17 Mar 2010 21:47:07 +0100

Experimental breast cancer drugs will be tested under a new DNA matching approach that aims to find which treatments work best and more quickly for certain patients. (Source: CBC | Health)

Tests for genes don't predict breast cancer better

Reuters: Health — Wed, 17 Mar 2010 21:39:09 +0100

BOSTON (Reuters) - Studying genes linked to breast cancer may someday lead to better treatments, but they do little to improve a doctor's ability to predict who is likely to develop a tumor, researchers reported on Wednesday. (Source: Reuters: Health)

Tests for Genes Don't Predict Breast Cancer Better

MedlinePlus Health News — Wed, 17 Mar 2010 20:39:09 +0100

Studying genes linked to breast cancer may someday lead to better treatments, but they do little to improve a doctor's ability to predict who is likely to develop a tumor, researchers reported on Wednesday.Source: Reuters Health Related MedlinePlus Pages: Breast Cancer, Genes and Gene Therapy (Source: MedlinePlus Health News)

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Breast Density Gains Acceptance As Breast Cancer Risk Factor

JNCI — Wed, 17 Mar 2010 20:01:15 +0100

(Source: JNCI)

Population-Based Study of Contralateral Prophylactic Mastectomy and Survival Outcomes of Breast Cancer Patients

JNCI — Wed, 17 Mar 2010 20:01:15 +0100

Conclusions CPM is associated with a small improvement in 5-year breast cancer–specific survival mainly in young women with early-stage ER-negative breast cancer. This effect is related to a higher baseline risk of contralateral breast cancer. (Source: JNCI)

Breast Cancer Prognosis and Occult Lymph Node Metastases, Isolated Tumor Cells, and Micrometastases

JNCI — Wed, 17 Mar 2010 20:01:15 +0100

Conclusion The presence (vs the absence) of metastases of 2 mm or less in diameter in axillary lymph nodes detected on single-section examination was associated with poorer disease-free and overall survival. (Source: JNCI)

SIR: Cryotherapy Conserves the Breast (CME/CE, with video)

MedPage Today Hematology/Oncology — Wed, 17 Mar 2010 19:28:43 +0100

TAMPA (MedPage Today) -- Multiprobe cryotherapy was safe and effective in breast cancer patients and didn't require subsequent surgery to ensure that all tumor cells were killed, researchers reported here. (Source: MedPage Today Hematology/Oncology)

Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose

HSMN NewsFeed — Wed, 17 Mar 2010 18:35:34 +0100

Cancer crusader's own sister is among first to receive Intraoperative Radiation Therapy on the Novac7 PHILADELPHIA, March 17 (HSMN NewsFeed) -- Technology never before offered in the U.S. that allows patients to receive one dose of radiation during su... Devices, OncologyNew Radiant Technology, Novac7, intraoperative radiation therapy, radiotherapy (Source: HSMN NewsFeed)

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Breast Cancer Study Aims to Speed Drugs, Cooperation

MedlinePlus Health News — Wed, 17 Mar 2010 16:49:56 +0100

Researchers launched a unique collaboration on Wednesday aimed at getting cancer drugs to the market more quickly in which three companies will cooperate with the U.S. government and non-profit groups to test five experimental breast cancer drugs. Source: Reuters Health Related MedlinePlus Pages: Breast Cancer, Medicines (Source: MedlinePlus Health News)

Association of sporadic breast cancer with PTEN/MMAC1/TEP1 promoter hypermethylation

Medical Oncology — Wed, 17 Mar 2010 15:51:54 +0100

In this study, PTEN promoter status and its correlation with genetic and pathologic parameters were analyzed in genomic DNA from Iranian patients with breast cancer. DNA methylation patterns in the CpG islands were determined by a methylation-specific PCR (MSP) assay. PTEN promoter methylation was found to be present in 37 of 53(70%) tumor tissues and none in 20 normal counterparts. Moreover, promoter methylation was found in patients with heterozygote mutation in the PTEN gene. The pathological history of cancerous tissue sections showed that PTEN gene could be inactivated at the stages III and IV in sporadic breast cancer. These findings suggested that promoter hypermethylation of PTEN might contribute to the progression of sporadic breast cancer in human. Content Type Journal A...

Better communication may improve understanding of genomic test results

MedWire News - Oncology — Wed, 17 Mar 2010 13:50:21 +0100

US researchers report that a significant number of women do not fully understand discussions about their genomic-based recurrence risk for breast cancer. (Source: MedWire News - Oncology)

Breast cancer study aims to speed drugs, cooperation

Reuters: Health — Wed, 17 Mar 2010 11:36:04 +0100

WASHINGTON (Reuters) - Researchers launched a unique collaboration aimed at getting cancer drugs to the market more quickly on Wednesday -- one in which three companies will cooperate with government and non-profit groups to test five experimental breast cancer drugs. (Source: Reuters: Health)

Short-Term Follow-Up of Palpable Breast Lesions With Benign Features

Medscape Today Headlines — Wed, 17 Mar 2010 11:04:30 +0100

Short-term follow-up of palpable breast lesions with benign features showed a low prevalence of breast cancer (3%), suggesting that ultrasound or mammography is a reasonable alternative to biopsy. American Journal of Roentgenology (Source: Medscape Today Headlines)

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Use of Erythropoietin-Stimulating Agents in Breast Cancer Patients: A Risk Review|74

Medscape Today Headlines — Wed, 17 Mar 2010 11:04:30 +0100

When should erythropoietin-stimulating agents be prescribed and how should these agents be dosed and monitored? American Journal of Health-System Pharmacy (Source: Medscape Today Headlines)

Encouraging Interventional Radiology Potential Treatment For Breast Cancer With Cryotherapy

Medical Devices News From Medical News Today — Wed, 17 Mar 2010 11:00:00 +0100

Encouraging Interventional Radiology Potential Treatment For Breast Cancer With Cryotherapy

Health News from Medical News Today — Wed, 17 Mar 2010 11:00:00 +0100

Freezing Out Breast Cancer

Breast Cancer News From Medical News Today — Wed, 17 Mar 2010 10:00:00 +0100

Freezing Out Breast Cancer

Health News from Medical News Today — Wed, 17 Mar 2010 10:00:00 +0100

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Agendia To Play Pivotal Role In ISPY-2 Trial For Breast Cancer

Pharmaceutical Online News — Wed, 17 Mar 2010 09:36:00 +0100

Agendia, a world leader in molecular cancer diagnostics, announced today it will participate in the highly anticipated I-SPY 2 TRIAL for breast cancer, set to launch at the first of nearly twenty research sites. (Source: Pharmaceutical Online News)

Case Managers Help Low-Income Women Receive More Timely Breast Cancer Diagnosis

Health News from Medical News Today — Wed, 17 Mar 2010 09:00:00 +0100

Case management appears to be associated with more appropriate follow-up and shorter time to diagnostic resolution among low-income women who receive an abnormal result on a mammogram, according to a report in the March 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Rebecca Lobb, Sc.D., M.P.H., of the Centre for Research on Inner City Health, St... (Source: Health News from Medical News Today)

Case Managers Help Low-Income Women Receive More Timely Breast Cancer Diagnosis

Breast Cancer News From Medical News Today — Wed, 17 Mar 2010 09:00:00 +0100

The 'ice ball' therapy that wipes out breast cancer cells

the Mail online | Health — Wed, 17 Mar 2010 07:55:46 +0100

The technique called cryotherapy is already used to treat prostate cancer. It involves inserting several needle-like 'cryoprobes' into the tumour and passing super-cold gas through them. (Source: the Mail online | Health)

US Preventative Services Task Force Mammography Recommendations Could Hinder Early Detection

Health News from Medical News Today — Wed, 17 Mar 2010 07:00:00 +0100

New research findings published in the March issue of the Journal of the American College of Surgeons indicate that some breast cancers continue to be detected as a palpable lump rather than being found through mammographic screening. Patients who presented with palpable tumors - those detected as a result of breast complaint or during examination - had larger tumors and were at a more advanced stage at diagnosis. The women who underwent yearly mammographic screening had the lowest rate of palpable presentation, in keeping with the reported benefit of mammography for early detection... (Source: Health News from Medical News Today)

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US Preventative Services Task Force Mammography Recommendations Could Hinder Early Detection

Breast Cancer News From Medical News Today — Wed, 17 Mar 2010 07:00:00 +0100

Pfizer Hid Evidence That HRT Causes Cancer

NaturalNews.com — Wed, 17 Mar 2010 07:00:00 +0100

(NaturalNews) A Philadelphia jury has found drug giant Pfizer Inc. guilty of deliberately ignoring evidence that hormone replacement therapy (HRT) drug Prempro increased women's risk of breast cancer, ordering it to pay unspecified damages to defendant Connie Barton.Millions of women used Prempro and other HRT drugs up until 2002, when the groundbreaking Women's Health Initiative study found that taking the drugs significantly increased women's risk of breast cancer and death from cardiovascular disease. The risk was so striking that researchers called an early halt to the study out of concern for participants' lives. The drugs were -- and still are -- marketed to relieve the symptoms of menopause, such as hot flashes, mood swings and night sweats.More recent research suggests that HRT dru...

Freezing Tumors Shows Promise Against Prostate, Breast Cancer

MedicineNet Cancer General — Wed, 17 Mar 2010 07:00:00 +0100

Title: Freezing Tumors Shows Promise Against Prostate, Breast CancerCategory: Health NewsCreated: 3/16/2010 10:10:00 AMLast Editorial Review: 3/17/2010 (Source: MedicineNet Cancer General)

Freezing Tumors Shows Promise Against Prostate, Breast Cancer

MedicineNet Mens Health General — Wed, 17 Mar 2010 07:00:00 +0100

Title: Freezing Tumors Shows Promise Against Prostate, Breast CancerCategory: Health NewsCreated: 3/16/2010 10:10:00 AMLast Editorial Review: 3/17/2010 (Source: MedicineNet Mens Health General)

Freezing Out Breast Cancer

Disabled World — Wed, 17 Mar 2010 02:34:50 +0100

First reported study shows encouraging interventional radiology potential treatment for breast cancer with cryotherapy, no need to undergo surgery after to ensure tumor killed. (Source: Disabled World)

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Octyl Methoxycinnamate Modulates Gene Expression and Prevents Cyclobutane Pyrimidine Dimer Formation but not Oxidative DNA Damage in UV-Exposed Human Cell Lines

Toxicological Sciences — Wed, 17 Mar 2010 00:49:58 +0100

Octyl methoxycinnamate (OMC) is one of the most widely used sunscreen ingredients. To analyze biological effects of OMC, an in vitro approach was used implying ultraviolet (UV) exposure of two human cell lines, a primary skin fibroblast (GM00498) and a breast cancer (MCF-7) cell lines. End points include cell viability assessment, assay of cyclobutane pyrimidine dimers (CPDs) and oxidated DNA lesions using alkaline elution and lesion-specific enzymes, and gene expression analysis of a panel of 17 DNA damage–responsive genes. We observed that OMC provided protection against CPDs, and the degree of protection correlated with the OMC-mediated reduction in UV dose. No such protection was found with respect to oxidative DNA lesions. Upon UV exposure in the presence of OMC, the gene expres...

Prostaglandin E2 Induces CYP1B1 Expression via Ligand-Independent Activation of the ER{alpha} Pathway in Human Breast Cancer Cells

Toxicological Sciences — Wed, 17 Mar 2010 00:49:57 +0100

Breast cancer is a major cause of death worldwide. Human cytochrome P450 (CYP) 1B1 is a key enzyme in the metabolism of 17β-estradiol, and CYP1B1-metabolized 4-hydroxyestradiol is a marker for breast cancer. Furthermore, overexpression of cyclooxygenase-2 (COX-2), which produces prostaglandin E2 (PGE2), has been detected in invasive breast carcinomas. However, the interaction between PGE2 and CYP1B1 expression in human breast cancer is unclear. Here, we investigated the effect of PGE2 on CYP1B1 expression and its mechanism in breast cancer cells. PGE2 significantly increased CYP1B1 protein and messenger RNA expression and dose dependently enhanced CYP1B1 promoter activity in human breast cancer MCF-7 cells. Transient transfection with human CYP1B1 (hCYP1B1) deletion promoter construct...

Climate Change And Poisonous Chemicals Focus Of New UN Study

Cancercompass News: Breast Cancer — Wed, 17 Mar 2010 00:00:00 +0100

A major new United Nations study will examine the influence of climate change and some of the worlds most hazardous chemicals on human health and the environment. The 12-month study, announced by the Secretariat of the Stockholm Convention, will provide the scientific community and policymakers with a better understanding of the effects of climate change on emissions, environmental distribution, toxicity and exposure to what is known as persistent organic pollutants (POPs). (Source: Cancercompass News: Breast Cancer)

Top five cancer controversies explained by experts at Cancer Research UK

Daily Express - Health — Wed, 17 Mar 2010 00:00:00 +0100

TALKING too long on your phone gives you brain tumours, deodorants give you breast cancer, reusing plastic water bottles releases cancer-causing chemicals. We've all heard the rumours, but should we take them seriously? (Source: Daily Express - Health)

The BRCAPRO 5.0 model is a useful tool in genetic counseling and clinical management of male breast cancer cases

European Journal of Human Genetics — Wed, 17 Mar 2010 00:00:00 +0100

Authors: Ines Zanna, Piera Rizzolo, Francesco Sera, Mario Falchetti, Paolo Aretini, Giuseppe Giannini, Giovanna Masala, Alberto Gulino, Domenico Palli & Laura Ottini (Source: European Journal of Human Genetics)

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Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma

European Journal of Clinical Investigation — Wed, 17 Mar 2010 00:00:00 +0100

Conclusion The high percentage of promoter methylation in the sFRP5 gene in OCCA indicates its importance in the development of OCCA and is a potential useful marker for prognoses and target for treatment of OCCA. (Source: European Journal of Clinical Investigation)

A qualitative analysis of acute skin toxicity among breast cancer radiotherapy patients

Psycho-Oncology — Wed, 17 Mar 2010 00:00:00 +0100

Conclusions: Implications of results are as follows: (1) skin toxicity affects numerous dimensions of QOL, and assessment approaches and psychosocial interventions should address this; (2) individual differences may affect the experience of skin toxicity and should be considered in treatment and education approaches; and (3) participants' own creativity and problem-solving should be used to improve the treatment experience. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Drug Combo Found Effective in HER2-Amplified Gastric Cancer

Modern Medicine — Wed, 17 Mar 2010 00:00:00 +0100

Lapatinib (Tykerb) and trastuzumab (Herceptin), two drugs already used in breast cancer treatment, are probably effective when used in combination against upper gastric cancers with the mutation for amplified expression of the human epidermal growth factor receptor 2 protein, according to a study in the March 1 issue of Clinical Cancer Research. (Source: Modern Medicine)

Genetic Variants Help Little in Breast Cancer Risk Model

Modern Medicine — Wed, 17 Mar 2010 00:00:00 +0100

Adding recently discovered common genetic variants to traditional risk models for breast cancer makes only a modest improvement in predictive value, according to research published in the March 18 issue of the New England Journal of Medicine. (Source: Modern Medicine)

Performance of Common Genetic Variants in Breast-Cancer Risk Models

New England Journal of Medicine — Wed, 17 Mar 2010 00:00:00 +0100

In this study, the addition of data on genetic variants associated with breast cancer yielded only a minor improvement in the performance of the model. (Source: New England Journal of Medicine)

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A Tiny Step Closer to Personalized Risk Prediction for Breast Cancer

New England Journal of Medicine — Wed, 17 Mar 2010 00:00:00 +0100

The completion of the first draft sequence of the Human Genome Project in 2001 heralded the arrival of personalized medicine, in which the risk and course of a disease can ... (Source: New England Journal of Medicine)

Case managers reduce diagnostic delay following an abnormal mammogram

MedWire News - Breast Cancer — Wed, 17 Mar 2010 00:00:00 +0100

Myriad breast cancer patent very broad, study finds

Reuters: Health — Tue, 16 Mar 2010 22:53:36 +0100

WASHINGTON (Reuters) - Myriad Genetics' disputed patent on the BRCA1 breast cancer gene is "surprisingly broad" and could interfere with future research, three experts said on Tuesday. (Source: Reuters: Health)

Sexual Pain and Dysfunction after Cancer Treatment

Women Speak — Tue, 16 Mar 2010 19:57:00 +0100

Patients undergoing cancer therapy are faced with many difficult side effects and changes in their bodies. For women, a frequent but unexpected side effect of cancer therapy is painful intercourse. Painful intercourse or dyspareunia may result from physical changes in the vagina following radiation and/or surgery or a depletion of the female hormone, estrogen, which can cause vaginal dryness. Female patients receiving certain chemotherapy agents may be at risk for premature menopause due to the effect of medication(s). Women with cancers of the cervix, uterus, ovaries, or vagina/vulva may undergo radical surgery or radiation, which leads to scarring and narrowing of the vagina. During treatment, most women and physicians are concerned with their battle against cancer, and there is ra...

Sexual Pain and Dysfunction after Cancer Treatment

Women Speak — Tue, 16 Mar 2010 19:57:00 +0100

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LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

The Wnt/β-catenin signaling pathway is activated in breast cancer, a leading cause of cancer mortality in women. Because mutations in... (Source: Proceedings of the National Academy of Sciences)

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells [Cell_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive... (Source: Proceedings of the National Academy of Sciences)

Cryotherapy successfully freezes breast cancer

AuntMinnie.com Headlines — Tue, 16 Mar 2010 18:50:34 +0100

Using image-guided multiprobe cryotherapy, researchers in Detroit have successfully (more) (Source: AuntMinnie.com Headlines)

Quantum dots highlight tumour heterogeneity

Nanotechweb.org journal highlights — Tue, 16 Mar 2010 18:20:06 +0100

Sensitive and specific test reveals differences among individual breast-cancer cells (Source: Nanotechweb.org journal highlights)

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

Breast Cancer Research and Treatment — Tue, 16 Mar 2010 14:50:08 +0100

In this study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2). Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samples. Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. β2-AR expression induced by epinephrine and involvement of ERK signaling were validated. The data indicate that Her2 overexpression and excessive phosphorylation of ERK cause epinephrine autocrine release from breast cancer cells, resulting in up-regulation of β2-AR expression. The data also showed that catecholamine prominently stimulated Her2 mRNA expression and promoter activity. The activation and nuclear transl...

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AIM: Case management improves time to diagnosis of breast cancer

Health Imaging News — Tue, 16 Mar 2010 14:12:13 +0100

Case management can improve the time to diagnosis of breast cancer for low income, underinsured women, according to an article published in the March 22 issue of the Archives of Internal Medicine. (Source: Health Imaging News)

AIM: Case management improves time to diagnosis of breast cancer

Health Imaging News — Tue, 16 Mar 2010 14:12:13 +0100

Timely Care After an Abnormal Mammogram Among Low-Income Women in a Public Breast Cancer Screening Program [Original Investigation]

Archives of Internal Medicine — Tue, 16 Mar 2010 13:56:15 +0100

Conclusions Case management to assist women in overcoming logistic and psychosocial barriers to care may improve time to diagnosis among low-income women who receive free breast cancer screening and diagnostic services. Programs that provide services to coordinate care, in addition to free screening and diagnostic tests, may improve population health.Published online March 16, 2010 (doi:10.1001/archinternmed.2010.22). (Source: Archives of Internal Medicine)

Screening and Detection of Breast Cancer and Prostate Cancer [Letters]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

(Source: JAMA)

Screening and Detection of Breast Cancer and Prostate Cancer [Letters]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

(Source: JAMA)

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Screening and Detection of Breast Cancer and Prostate Cancer [Letters]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

(Source: JAMA)

Screening and Detection of Breast Cancer and Prostate Cancer--Reply [Letters]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

(Source: JAMA)

Freezing Tumors Shows Promise Against Prostate, Breast Cancer

MedlinePlus Health News — Tue, 16 Mar 2010 13:00:00 +0100

Cryotherapy prevented need for surgery in one group, and thwarted recurrence in the other Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Prostate Cancer (Source: MedlinePlus Health News)

Involvement of Breast Cancer Resistance Protein (BCRP1/ABCG2) in the Bioavailability and Tissue Distribution of trans-Resveratrol in Knockout Mice

Journal of Agricultural and Food Chemistry — Tue, 16 Mar 2010 12:28:36 +0100

Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)