MedWorm: Breast Cancer

Research Library: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer

Nature Signaling Update — Fri, 20 Nov 2009 15:16:38 +0100

(Source: Nature Signaling Update)

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Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

MedWire News - Breast Cancer — Fri, 20 Nov 2009 13:49:33 +0100

Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests. (Source: MedWire News - Breast Cancer)

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

MedWire News - Oncology — Fri, 20 Nov 2009 13:49:33 +0100

Insurers Say They Won't Alter Mammogram Coverage Despite New Guidelines

Health News from Medical News Today — Fri, 20 Nov 2009 12:00:00 +0100

Insurance companies say mammogram coverage is unlikely to change despite the debate over the effectiveness of breast cancer screenings for women in their forties. (Source: Health News from Medical News Today)

HHS Sec. Sebelius Says New Mammogram Guidelines Will Not Change Federal Policies

Health News from Medical News Today — Fri, 20 Nov 2009 11:00:00 +0100

HHS Secretary Kathleen Sebelius on Wednesday said that federal health insurance programs will not alter their mammogram coverage policies following new recommendations from the U.S. Preventive Services Task Force, the New York Times reports. The guidelines, released earlier this week, promote mammograms every two years for most women starting at age 50. (Source: Health News from Medical News Today)

Esteemed Endorsements Recognize Promising Future Of Breast-Specific Gamma Imaging (BSGI)

Breast Cancer News From Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

Breast-Specific Gamma Imaging/Molecular Breast Imaging (BSGI/MBI) has been recognized and endorsed by two highly esteemed organizations for the fight against breast cancer: The Society of Breast Imaging (SBI) and the American College of Surgeons. Both societies published articles supporting the further application of this breakthrough imaging technology for the early detection of breast cancer. (Source: Breast Cancer News From Medical News Today)

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Esteemed Endorsements Recognize Promising Future Of Breast-Specific Gamma Imaging (BSGI)

Health News from Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

Group recommends less-frequent Pap tests

Los Angeles Times - Science — Fri, 20 Nov 2009 08:00:00 +0100

The cervical cancer screening advice follows another panel's controversial mammogram report, but experts say it's a much different situation. Still, Paps are the only reason some women see a doctor. Only days after a federal panel scaled back on breast cancer screening recommendations for many women, another organization -- the American College of Obstetricians and Gynecologists -- has done the same for a screening credited with drastically reducing the rates of cervical cancer in the U.S. (Source: Los Angeles Times - Science)

Adding tools against breast tumors

ScienceDaily Headlines — Fri, 20 Nov 2009 07:00:00 +0100

At the end of a 10-year, coast-to-coast study of women with an unusual form of breast cancer, medical researchers are making the case for a particular combination of treatments to stop the tumors in their tracks. (Source: ScienceDaily Headlines)

Mammogram Debate Took Group by Surprise

NYT > Health — Fri, 20 Nov 2009 06:27:35 +0100

The Preventive Services Task Force, which urged women to get less-frequent screening for breast cancer, was created to be apolitical. (Source: NYT > Health)

Effect of Collimator and Couch Angle Change on Breast IMRT Dose Distributions.

Journal of Applied Clinical Medical Physics — Fri, 20 Nov 2009 06:02:03 +0100

The objective of this work is to investigate the effects of the collimator and the couch angle change on the dose distribution for breast cancer treatment using intensity modulated tangential photon beams, and thus to determine the clinical acceptable range of the angle change for routine treatment. Ten breast cases treated with intensity modulated tangential photon beams were analyzed in this study. Patient-specific CT data and the RTP files obtained from our home-grown Monte Carlo based breast IMRT treatment planning system were used for IMRT dose re-calculation with collimator or couch angle changes. The isodose distributions and DVHs were compared with the original plans and the effects of the collimator and couch angle change to breast IMRT dose distributions were evaluated. Our resul...

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Group Clarifies Mammography Advice

WSJ.com: Health — Fri, 20 Nov 2009 05:22:49 +0100

The task force that loosened breast-cancer screening guidelines this week clarified its position, in response to the intense backlash its new recommendations have prompted. (Source: WSJ.com: Health)

Group Clarifies Mammograph Advice

WSJ.com: Health — Fri, 20 Nov 2009 02:32:32 +0100

The task force that loosened breast-cancer screening guidelines this week clarified its position, in response to the intense backlash its new recommendations have prompted. (Source: WSJ.com: Health)

Group Clarifies Mammography Advice

WSJ.com: Health — Fri, 20 Nov 2009 00:27:10 +0100

The task force that loosened breast-cancer screening guidelines this week clarified its position, in response to the intense backlash its new recommendations have prompted. (Source: WSJ.com: Health)

Management of Symptomatic Bone Metastases from Breast Cancer with Concomitant Use of External Radiotherapy and Ibandronate: Results of a Prospective, Pilot Study

The Breast Journal — Fri, 20 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Breast Cancer Survivors Disagree With New Mammogram Advice

Cancercompass News: Breast Cancer — Fri, 20 Nov 2009 00:00:00 +0100

After losing her mother to cancer, Shelia Weeks, 61, was advised by her doctor to begin receiving mammograms when she was 36. Her mother's cancer was found in her liver, but started in her breast. There was no widespread detection method such as mammograms at that time. She passed away in 1982. (Source: Cancercompass News: Breast Cancer)

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Characterisation of microRNA expression in post-natal mouse mammary gland development

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: MicroRNAs were expressed in likely co-regulated clusters during mammary gland development. Breast cancer-associated miRNAs were significantly enriched in these clusters. The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation. (Source: BioMed Central)

Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cells

BMC Genomics - Latest articles — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: Our analysis indicated that a time-dependent transcriptional regulatory network including c-FOS, FRA-1, and FHL2 is vital in controlling the ERK signaling pathway through a negative feedback loop for MCF-7 cell differentiation. (Source: BMC Genomics - Latest articles)

Breast Cancer Screening: New Fuel for an Old War of Words and Data

MedPage Today Hematology/Oncology — Thu, 19 Nov 2009 22:44:24 +0100

A controversy that has alternately simmered and boiled for more than 40 years reached a flash point this week when the U.S. Preventive Services Task Force published recommendations for breast cancer screening with mammography. (Source: MedPage Today Hematology/Oncology)

Multifunctional Block Copolymer Micelles for the Delivery of 111In to EGFR-Positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy

Molecular Pharmaceutics — Thu, 19 Nov 2009 19:31:57 +0100

Molecular Pharmaceutics, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Molecular Pharmaceutics)

Dayton group argues for regular mammograms

bizjournals.com Health Care:Health Insurance headlines — Thu, 19 Nov 2009 19:12:07 +0100

The Dayton breast cancer task force disagrees with new recommendations from the U.S. Preventative Services Task Force that women should not receive regular mammograms until they reach their 50s. (Source: bizjournals.com Health Care:Health Insurance headlines)

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Dayton group argues for regular mammograms

bizjournals.com Health Care:Biotechnology headlines — Thu, 19 Nov 2009 19:12:07 +0100

False positive on breast cancer | Sarah Wildman

Guardian Unlimited Science — Thu, 19 Nov 2009 19:00:00 +0100

A panel's recommendation that American women need fewer mammograms would mean more deaths from breast cancerIn the US we've heard the refrain for two decades: early detection saves lives. But this week a federal advisory board decided that while that slogan wasn't false, in the case of breast cancer, it just wasn't true enough. After years of pink ribbons and breast cancer marches and admonishments to examine our breasts, this week the US Preventative Services Task Force bucked conventional wisdom (and the American Cancer Society) claiming that the number of women saved by early detection through mammography was not enough to warrant the recommendations nearly every schoolchild can recite: a mammogram a year after age 40. Citing anxiety – real, as every woman who has waited for her mammo...

Stefanie Spielman, wife of Ohio State and NFL star, dies at 42 after long battle with cancer

OrlandoSentinel: Medical Research — Thu, 19 Nov 2009 17:43:00 +0100

COLUMBUS, Ohio (AP) — Stefanie Spielman, the wife of NFL and Ohio State star Chris Spielman who led a public fight against breast cancer, died Thursday after a lengthy battle with the disease. She was 42. Stefanie Spielman died at the family's home... (Source: OrlandoSentinel: Medical Research)

Stefanie Spielman, wife of NFL star, dies at 42

OrlandoSentinel: Medical Research — Thu, 19 Nov 2009 17:34:00 +0100

Stefanie Spielman, the wife of NFL and Ohio State star Chris Spielman who led a public fight against breast cancer, died Thursday after a lengthy battle with the disease. She was 42. Stefanie Spielman died at the family's home in Upper Arlington,... (Source: OrlandoSentinel: Medical Research)

Secretary Sebelius Statement On New Breast Cancer Recommendations

Health News from Medical News Today — Thu, 19 Nov 2009 17:00:00 +0100

HHS Secretary Kathleen Sebelius issued the following statement today on new breast cancer screening recommendations from the U.S. Preventive Services Task Force: "There is no question that the U.S. Preventive Services Task Force Recommendations have caused a great deal of confusion and worry among women and their families across this country. I want to address that confusion head on. The U.S. (Source: Health News from Medical News Today)

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Secretary Sebelius Statement On New Breast Cancer Recommendations

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 17:00:00 +0100

New Breast Cancer Screening Guidelines Opposed by Societies

Medscape Today Headlines — Thu, 19 Nov 2009 16:35:47 +0100

The ACS, ACR, and ACOG advocate continuing to follow their own current guidelines and not adopting the new USPSTF recommendations. Medscape Medical News (Source: Medscape Today Headlines)

Methods for Compensating for Variable Electrode Contact in EIT

IEEE Transactions on Biomedical Engineering — Thu, 19 Nov 2009 16:31:27 +0100

Electrical impedance tomography (EIT) is an imaging modality that currently shows promise for the detection and characterization of breast cancer. A very significant problem in EIT imaging is the proper modeling of the interface between the body and the electrodes. We have found empirically that it is very difficult, in a clinical setting, to assure that all electrodes make satisfactory contact with the body. In addition, we have observed a capacitive effect at the skin/electrode boundary that is spatially heterogeneous. To compensate for these problems, we have developed a hybrid nonlinear–linear reconstruction algorithm using the complete electrode model in which we first estimate electrode surface impedances, by means of a Levenberg–Marquardt iterative optimization procedu...

Secretary Sebelius Statement on New Breast Cancer Recommendations

News stories via the Rural Assistance Center — Thu, 19 Nov 2009 16:12:13 +0100

HHS Secretary Kathleen Sebelius issued a statement yesterday on new breast cancer screening recommendations from the U.S. Preventive Services Task Force, saying that the guidelines were the product of an outside, expert panel that does not "set federal policy and they don't determine what services are covered by the federal government." (Source: News stories via the Rural Assistance Center)

The History of Oncology

International Journal of Radiation Oncology * Biology * Physics — Thu, 19 Nov 2009 15:21:30 +0100

A Google search on the phrase “history of oncology” brings up approximately 1,700,000 hits, including helpful entries testifying to the excellence of several-thousand individual oncologists and a similar number of promotional advertisements for local, regional, and national self-designated “centers of excellence” in the very latest types of cancer care. With the current hospital marketing emphasis on “cutting-edge” new technologies, it would be easy to imagine that the field of oncology arose in recent decades from peer-reviewed medical evidence drawn from modern biomolecular sciences and digital technologies. However, as most students of medical history are aware, the field of oncology is actually one of the older branches of medicine, and skeletons showing evidence of rudimen...

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Sebelius Statement on New Breast Cancer Recommendations

NurseZone.com Nursing News — Thu, 19 Nov 2009 14:51:40 +0100

Nov. 18, 2009 - HHS Secretary Kathleen Sebelius issued the following statement today on new breast cancer screening recommendations from the U.S. Preventive Services Task Force: (Source: NurseZone.com Nursing News)

Breast Cancer Campaign: New Breast Cancer Research Funding For Belfast

Health News from Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

Individualised radiotherapy treatment based on a person's genetic make up could soon become a reality, according to Breast Cancer Campaign. Professor Kevin Prise from Queen's University Belfast has been awarded a three year project grant by the charity to study how genes are involved in the effectiveness of radiotherapy treatment for breast cancer. (Source: Health News from Medical News Today)

Some Physicians Say New Breast Cancer Screening Guidelines Unlikely To Alter Their Practices

Health News from Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

One day after the release of new breast cancer screening guidelines, many physicians and some medical groups are saying that they do not plan to adopt the new recommendations -- which represent a drastic change -- the New York Times reports (Belluck, New York Times, 11/18). The guidelines, released by the U.S. (Source: Health News from Medical News Today)

Some Physicians Say New Breast Cancer Screening Guidelines Unlikely To Alter Their Practices

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

Breast Cancer Campaign: New Breast Cancer Research Funding For Belfast

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

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Longer consultations improve patient satisfaction with surgical treatment

MedWire News - Oncology — Thu, 19 Nov 2009 13:49:56 +0100

Most low-income women with breast cancer are extremely satisfied with the treatment they received from their surgeon, study findings indicate. (Source: MedWire News - Oncology)

Hall of Famers John Thompson, Kay Yow receive Lapchick Coaching Integrity Awards

OrlandoSentinel: Medical Research — Thu, 19 Nov 2009 13:41:00 +0100

NEW YORK (AP) — John Thompson and Kay Yow first shared a special experience 21 years ago as coaches of the U.S. men's and women's Olympic basketball teams. On Thursday, 10 months after Yow lost a long battle with breast cancer, she and Thompson... (Source: OrlandoSentinel: Medical Research)

Tempest Over New Mammography Guidelines Affect Health Legislation, Insurance Coverage

Health News from Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Newspapers across the country featured front-page follow-up stories on new mammogram recommendations today.The U.S. (Source: Health News from Medical News Today)

Tempest Over New Mammography Guidelines Affect Health Legislation, Insurance Coverage

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Newspapers across the country featured front-page follow-up stories on new mammogram recommendations today.The U.S. Preventive Services Task Force -- "which recommended that women in their 40s should no longer get annual mammograms to screen for breast cancer -- sparked an outcry from those who say that the federal government is more interested in saving money than in improving women's health, even though the panel did not consider costs in its analysis," the (Source: Breast Cancer News From Medical News Today)

Who decides on mammograms? Inside task force

CNN.com - Health — Thu, 19 Nov 2009 12:20:55 +0100

Breast cancer surgeons, cancer organizations and even the White House are expressing concern about new screening recommendations. (Source: CNN.com - Health)

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Breast Cancer & Bacteria

OrlandoSentinel: Medical Research — Thu, 19 Nov 2009 11:47:06 +0100

For more information about the breast cancer & bacteria study, check out www.rush.edu/rumc. Doctors have a gut feeling about breast cancer beginning in the intestines. Bacteria there may be the key to breeding breast tumors. Nurse: "She is receiving... (Source: OrlandoSentinel: Medical Research)

Radiation Breakthrough Gives Breast Cancer Patients Hope In Single Dose

Health News from Medical News Today — Thu, 19 Nov 2009 11:00:00 +0100

A radiation breakthrough to treat breast cancer patients in one day, as opposed to the current average of six weeks, has arrived at Cancer Treatment Centers of America(R) (CTCA) in Philadelphia. CTCA will become the first in the country to offer this treatment option using the Novac7 technology from Rome, Italy. (Source: Health News from Medical News Today)

Radiation Breakthrough Gives Breast Cancer Patients Hope In Single Dose

Radiology / Nuclear Medicine News From Medical News Today — Thu, 19 Nov 2009 11:00:00 +0100

Media Coverage Of New Mammography Guidelines Confusing To Some, Says Expert

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

The public may have problems this week sorting through news articles about a government task force's opposition to routine mammograms for women under 50 and articles about breast cancer survivors touting the benefits of early mammograms. But to properly interpret the news, the public must learn to balance the research with the anecdotal evidence says University of Alabama at Birmingham (UAB) Associate Professor of English Cynthia Ryan, Ph.D. (Source: Breast Cancer News From Medical News Today)

US Mammogram Policy Will Not Change Says Health Secretary

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

US secretary for Health and Human Services (HHS) has issued a statement saying that the government policy on what age routine screening mammograms should begin has not changed, following a recent task force recommendation that routine screening mammograms should start at age 50 and not age 40. (Source: Breast Cancer News From Medical News Today)

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Media Coverage Of New Mammography Guidelines Confusing To Some, Says Expert

Health News from Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

Spotlight: New Mammogram Guidelines

TIME.com: Top Science and Health Stories — Thu, 19 Nov 2009 08:22:53 +0100

An independent government panel this week abandoned its long-standing recommendation that healthy women over 40 get a breast-cancer screen once every year or two years (Source: TIME.com: Top Science and Health Stories)

Sebelius distances herself from new mammogram guidelines

Los Angeles Times - Science — Thu, 19 Nov 2009 08:00:00 +0100

The secretary says panel of experts doesn't set federal policy. Some critics link recommendations to healthcare reform debate. Health and Human Services Secretary Kathleen Sebelius said Wednesday that the controversial new guidelines for breast cancer screening do not represent government policy, as the Obama administration sought to keep the debate over mammograms from undermining the prospects for healthcare reform. (Source: Los Angeles Times - Science)

Breast Cancer Screening Policy Won’t Change, U.S. Officials Say

NYT — Thu, 19 Nov 2009 07:06:18 +0100

The White House emphasized that the new screening standards were not binding on either physicians or insurers. (Source: NYT)

Cancer industry desperately needs mammogram screenings to recruit patients and generate repeat business

NaturalNews.com — Thu, 19 Nov 2009 07:00:00 +0100

(NaturalNews) Any time you threaten to take away repeat customer from the businesses that make up the cancer industry, you're in for a political fight. After the United States Preventive Services Task Force released new recommendations advising against mammograms for women under 50 (and recommending only bi-annual screenings after that), the cancer industry went berserk.Mammograms, you see, are the bread and butter of the for-profit cancer industry. They serve two very important purposes:Purpose #1: RECRUIT patients. Mammograms are a clever tool for recruiting patients into a highly-profitable regimen of chemotherapy drugs, radiation and surgery that, nine times out of ten, isn't even medically justified. How's that? Because the detection technology behind mammograms is now so advanced it ...

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Insurers Unlikely to Alter Policies in the Debate Over Mammograms

NYT > Health — Thu, 19 Nov 2009 06:39:29 +0100

Medicare and private health insurers said they were unlikely to change coverage of breast cancer screenings after new guidelines recommended that women wait longer to have mammograms and have fewer of them. (Source: NYT > Health)

Insurers Unlikely to Alter Policies in the Debate Over Mammograms

NYT — Thu, 19 Nov 2009 06:39:29 +0100

Breast Cancer Screening Policy Won’t Change, U.S. Officials Say

NYT > Health — Thu, 19 Nov 2009 06:10:46 +0100

The White House emphasized that the new screening standards were not binding on either physicians or insurers. (Source: NYT > Health)

Breast cancer: Early detection is key

MayoClinic.com Full Feed — Thu, 19 Nov 2009 06:00:00 +0100

Breast cancer — Comprehensive overview covers symptoms, causes, diagnosis, treatment of breast cancer in women. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

Breast Exam Guidelines Raise Furor

WSJ.com: Health — Thu, 19 Nov 2009 05:34:51 +0100

Sebelius tried to dispel concerns that new guidelines on breast-cancer screening threaten insurance coverage amid debate among patients, medical professionals and legislators. (Source: WSJ.com: Health)

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White House backs off cancer test guidelines

Wash Post Health — Thu, 19 Nov 2009 05:00:00 +0100

A top federal health official said Wednesday that the controversial new guidelines for breast cancer screening do not represent government policy, as the Obama administration sought to keep the debate over mammograms from undermining the prospects for health-care reform. (Source: Wash Post Health)

U.S. official says mammograms policy unchanged

Reuters: Health — Thu, 19 Nov 2009 03:00:30 +0100

CHICAGO (Reuters) - U.S. health officials distanced themselves Wednesday from controversial new breast cancer screening guidelines that recommend against routine mammograms for healthy women in their 40s and said federal policy on screening mammograms had not changed. (Source: Reuters: Health)

Mammogram guidelines: What's changed?

MayoClinic.com - Ask a Specialist — Thu, 19 Nov 2009 02:45:03 +0100

Latest mammogram guidelines for breast cancer screening. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com - Ask a Specialist)

Official says mammograms policy unchanged

Reuters: Health — Thu, 19 Nov 2009 02:24:38 +0100

CHICAGO (Reuters) - U.S. health officials distanced themselves on Wednesday from controversial new breast cancer screening guidelines that recommend against routine mammograms for healthy women in their 40s and said federal policy on screening mammograms had not changed. (Source: Reuters: Health)

Susan G. Komen For The Cure(R) Recommends No Impediments To Breast Cancer Screening

Health News from Medical News Today — Thu, 19 Nov 2009 02:00:00 +0100

Susan G. Komen for the Cure®, the world's leading breast cancer advocacy organization, has carefully reviewed the data and new recommendations from the U.S. Preventive Services Task Force (USPSTF) concerning mammography screening. Komen for the Cure issued the following statement today from Eric P. Winer, M.D., chief scientific advisor and chair of Komen's Scientific Advisory Board. (Source: Health News from Medical News Today)

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Susan G. Komen For The Cure(R) Recommends No Impediments To Breast Cancer Screening

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 02:00:00 +0100

Breast Exam Guidelines Raise Furor

WSJ.com: Health — Thu, 19 Nov 2009 01:42:43 +0100

Breast Cancer: Search of Hidden Culprits

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

SPECT/CT for preoperative sentinel node localization

Journal of Surgical Oncology — Thu, 19 Nov 2009 00:00:00 +0100

The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies non-nodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes). J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)

Discontinuation of Radiation Treatment among Medicaid-Enrolled Women with Local and Regional Stage Breast Cancer

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: For women with nonmetastatic breast cancer, radiation therapy is recommended as a necessary component of the breast conserving surgery (BCS) treatment option. The degree to which Medicaid-enrolled women complete recommended radiation therapy protocols is not known. We evaluate radiation treatment completion rates for Medicaid enrollees aged 18[ndash]64 diagnosed with breast cancer. We determine clinical and socio-demographic factors associated with not starting treatment, and with interruptions or not completing radiation treatment. Using data from the Washington State Cancer Registry linked to Medicaid enrollment and claims records, we identified Medicaid enrollees diagnosed with breast cancer from 1997 to 2003 who received BCS. Among the 402 women who met inclusion criteria, 10...

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Early Response to Neo-adjuvant Chemotherapy in Carcinoma of the Breast Predicts Both Successful Breast-Conserving Surgery and Decreased Risk of Ipsilateral Breast Tumor Recurrence

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

In conclusion, the early response to neo-adjuvant chemotherapy may be a useful predictor of both selection of surgical method and IBTR risk. (Source: The Breast Journal)

Estrogen Deprivation Therapy and Colon Cancer Risk in Breast Cancer Patients

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Obesity Increases the Risk of Postmenopausal Breast Cancer and is Associated with More Advanced Stage at Presentation But no Impact on Survival

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose

Cancercompass News: Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

AQUA Technology Recognized As Promising New Strategy For Hormone Receptor Testing In Breast Cancer By NCCN Task Force

Cancercompass News: Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

HistoRx today announced that the Company's proprietary AQUA technology, an automated image analysis platform based on tissue-based quantitative immunofluorescence, was noted in a recent National Comprehensive Cancer Network (NCCN) Task Force Report on hormone receptor testing in breast cancer as one of the promising new strategies being developed for the measurement of ER and PgR in breast cancer tissue. (Source: Cancercompass News: Breast Cancer)

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FNCLCC-PACS 04 trial of trastuzumab for patients with axillary-node-positive breast cancer finds no benefit in adjuvant setting

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: J Clin Oncol Area: News The PACS04 trial initiated in 2001 aimed to evaluate the efficacy of concomitant use of docetaxel with anthracyclines, and the efficacy of trastuzumab given for 1 year after the end of adjuvant chemotherapy in patients with axillary node-positive breast cancer. In this paper, results of the second randomisation (i.e. evaluation of trastuzumab efficacy in the adjuvant setting in human epidermal growth factor receptor 2 (HER2)-positive patients -FNCLCC-PACS 04 trial) are reported. The initial study involved 3010 patients with operable node-positive breast cancer who were randomised to receive adjuvant anthracycline-based chemotherapy with or without docetaxel. Those who presented HER2-overexpressing tumours (n= 528) were secondarily randomised to e...

Oocyte retrieval does not delay adjuvant chemotherapy

MedWire News - Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report. (Source: MedWire News - Breast Cancer)

Oocyte retrieval does not delay adjuvant chemotherapy

MedWire News - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report. (Source: MedWire News - Oncology)

Synthesis and Antiproliferative Activitiy of Novel Diaryl Ureas Possessing a 4H-Pyrido[1,2-a]pyrimidin-4-one Group

Archiv der Pharmazie — Thu, 19 Nov 2009 00:00:00 +0100

We herein disclose a series of novel diaryl urea derivatives possessing a 4H-pyrido[1,2-a]pyrimidin-4-one group as novel potent anticancer compounds. The structures were confirmed by IR, 1H-NMR, and MS. All the compounds were screened for their antiprofilerative activity agaist the human breast cancer cell line (MDA-MB-231). The pharmacological results indicated that most of the compounds showed moderate activity. The best of this series is compound 4c (IC50 = 0.7 [mu]mol/L), with a potency 3.6-fold higher than Sorafenib (IC50 = 2.5 [mu]mol/L), which was approved in 2005. (Source: Archiv der Pharmazie)

The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade

The Journal of Pathology — Thu, 19 Nov 2009 00:00:00 +0100

In the last decade, the development of microarrays and the ability to perform massively parallel gene expression analysis of human tumours were received with great excitement by the scientific community. The promise of microarrays was of apocalyptic dimensions, with some experts envisaging that it would be a matter of a few years for this technology to replace traditional clinicopathological markers in clinical practice and treatment decision-making. The replacement of histopathology by high-tech and more objective approaches to cancer diagnosis, prognostication and prediction was, at that time, a foregone conclusion. Ten years after the initial publications of translational research studies using microarrays, one cannot deny that this technology has changed the way breast cancer is percei...

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Mapping oncology services in regional and rural Australia

Australian Journal of Rural Health — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: Survey data highlight marked cancer service deficiencies in rural and regional Australia. It is not unreasonable to conclude that these deficiencies might contribute to poorer outcomes for cancer patients living in these areas. The results suggest the need for short- and long-term measures to improve access to best-practice cancer services for patients living in regional, rural and remote areas of Australia. (Source: Australian Journal of Rural Health)

CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non-hodgkin's lymphoma

Journal of Clinical Laboratory Analysis — Thu, 19 Nov 2009 00:00:00 +0100

Chemokines and their receptors regulate the trafficking of immune cells during their development, inflammation, and tissue repair. The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/ stromal cell-derived factor-1 (SDF1)-3[prime]A) in CXCL12/SDF1 gene was assessed in breast cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL), since the chemokine CXCL12, previously known as SDF1, and its receptor CXCR4 regulate leukocyte trafficking and many essential biological processes, including tumor growth, angiogenesis, and metastasis of different types of tumors. Genotyping was performed by PCR-RFLP (polymerase chain reaction followed by restriction fragment length polymorphism) using a restriction enzyme HpaII cleavage. No significant difference was observ...

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management [REVIEW ARTICLE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion MRI detects contralateral lesions in a substantial proportion of women, but does not reliably distinguish benign from malignant findings. Relatively high ICDR may be due to selection bias and/or overdetection. Women must be informed of the uncertain benefit and potential harm, including additional investigations and surgery. (Source: Journal of Clinical Oncology)

How to Treat Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Amplified Breast Cancer [EDITORIALS]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

(Source: Journal of Clinical Oncology)

Axillary Reverse Mapping to Prevent Lymphedema After Breast Cancer Surgery: Defining the Limits of the Concept [EDITORIALS]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

(Source: Journal of Clinical Oncology)

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Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Results From the Randomized Phase III TAnDEM Study [Breast Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

Conclusion Trastuzumab plus anastrozole improves outcomes for patients with HER2/hormone receptor–copositive MBC compared with anastrozole alone, although adverse events and serious adverse events were more frequent with the combination. (Source: Journal of Clinical Oncology)

Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor-Positive Metastatic Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

Conclusion This trial demonstrated that a combined targeted strategy with letrozole and lapatinib significantly enhances PFS and clinical benefit rates in patients with MBC that coexpresses HR and HER2. (Source: Journal of Clinical Oncology)

Extensive Nodal Disease May Impair Axillary Reverse Mapping in Patients With Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

Conclusion In patients with clinically negative axillary nodes, additional study is warranted to assess whether ARM may be used to spare the lymphatics from the arm. In the presence of extensive nodal disease, this technique may identify metastatic blue nodes, which demonstrates that there is not reliable separation of arm and breast lymphatic pathways. (Source: Journal of Clinical Oncology)

Prognostic and Predictive Value of HER2 Extracellular Domain in Metastatic Breast Cancer Treated With Lapatinib and Paclitaxel in a Randomized Phase III Study [Breast Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

Conclusion HER2 bECD does not predict lapatinib benefit in patients with HER2-negative MBC. Changes in ECD status correlates with patient outcome regardless of treatment given. Measuring HER2 ECD is not currently recommended for predicting benefit to lapatinib. (Source: Journal of Clinical Oncology)

USPSTF Makes Sweeping Changes to Breast Cancer Screening Recommendations

AAFP Health of the Public — Wed, 18 Nov 2009 23:00:00 +0100

The U.S. Preventive Services Task Force, or USPSTF, has updated its recommendations for breast cancer screening with some significant changes, including a recommendation against routine screening mammography for women ages 40-49 who aren't at increased risk for breast cancer. (Source: AAFP Health of the Public)

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U.S. official says mammograms policy unchanged

Reuters: Health — Wed, 18 Nov 2009 22:12:06 +0100

CHICAGO (Reuters) - U.S. health officials on Wednesday distanced themselves from controversial new breast cancer screening guidelines that recommend against routine mammograms for healthy women in their 40s and said federal policy on screening mammograms has not changed. (Source: Reuters: Health)

U.S. Official Says Mammograms Policy Unchanged

MedlinePlus Health News — Wed, 18 Nov 2009 22:12:06 +0100

U.S. health officials on Wednesday distanced themselves from controversial new breast cancer screening guidelines that recommend against routine mammograms for healthy women in their 40s and said federal policy on screening mammograms has not changed. Source: Reuters Health Related MedlinePlus Topic: Mammography (Source: MedlinePlus Health News)

TP53 codon 72 polymorphism and breast cancer in northern Iran.

Oncology Research — Wed, 18 Nov 2009 21:26:03 +0100

In this study, we investigated p53 codon 72 polymorphism in 42 breast cancer cases and 60 healthy individual in northern Iran. Genomic DNA was extracted from fresh tumor tissues of patients and blood samples of healthy individuals. AS-PCR method was applied for determination of codon 72 polymorphism. The distribution of genotypes in breast cancer cases and controls were different (p = 0.001). Pro allele was significantly associated with the presence of breast cancer (odds ratio = 1.5 and 95% confidence interval = 0.85-2.63). Pro/Pro genotype was overrepresented in breast cancer. Based on these data, it is suggested that Pro allele may modify the risk of breast cancer in northern Iranian women. PMID: 19911701 [PubMed - in process] (Source: Oncology Research)

Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines.

Oncology Research — Wed, 18 Nov 2009 21:26:03 +0100

Authors: Elahian F, Kalalinia F, Behravan J It is hypothesized that anti-inflammatory drugs regulate breast cancer resistance protein (BCRP) expression. Hence, we examined the effects of indomethacin and dexamethasone on BCRP expression in MCF cells. For evaluation of BCRP mRNA expression, relative quantitative PCR and comparative C1 method was exploited. BCRP protein expression was measured flow cytometrically with the monoclonal antibody (mAb) BXP-21. Dexamethasone showed a dose-independent and a time-dependent effect on decreasing the mRNA level of BCRP gene in comparison with control in MCF-7 and MCF-7/MX breast cancer cell lines, whereas no changes were noted in the presence of indomethacin. The level of BCRP protein, expressed as a ratio of the corresponding control, was decrease...

Sebelius Statement on New Breast Cancer Recommendations

HSMN NewsFeed — Wed, 18 Nov 2009 21:22:47 +0100

WASHINGTON--(HSMN NewsFeed)--HHS Secretary Kathleen Sebelius issued the following statement today on new breast cancer screening recommendations from the U.S. Preventive Services Task Force: There is no question that the U.S. Preventive Services Task F... Devices, Oncology, Radiologymammogram, mammography, breast cancer (Source: HSMN NewsFeed)

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Sebelius: U.S. policy on mammograms 'unchanged'

Wash Post Health — Wed, 18 Nov 2009 20:31:59 +0100

A top Obama administration official on Wednesday appeared to try to distance the federal government from controversial new guidelines recommending fewer women routinely undergo mammograms to screen for breast cancer. (Source: Wash Post Health)

Sebelius: mammograms still vital in saving lives

USATODAY.com Health — Wed, 18 Nov 2009 20:01:01 +0100

Federal policy on who should get breast cancer screening has not changed, Health and Human Services Secretary Kathleen Sebelius ... (Source: USATODAY.com Health)

Health officials say policy on mammograms unchanged

Reuters: Health — Wed, 18 Nov 2009 19:30:56 +0100

Ex-Kiss drummer talks about surviving breast cancer

CTV Health — Wed, 18 Nov 2009 18:32:30 +0100

Former Kiss drummer Peter Criss is speaking out about his own breast cancer diagnosis two years ago in an effort to encourage other men to get tested for the disease if they think something is amiss. (Source: CTV Health)

Medical Experts Weigh In On Mammogram Controversy

Wed, 18 Nov 2009 17:04:16 +0100

Sweeping new U.S. breast cancer screening guidelines are calling for an end to routine mammograms for women in their 40s and for women 50 to 74 they suggest a mammogram every other year. At age 40, yearly mammograms become part of a woman's life to look for breast cancer. Now a government task force says it is okay to wait until you're 50 to get this screening test. Some women are concerned about waiting an extra decade. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

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Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose

HSMN NewsFeed — Wed, 18 Nov 2009 16:27:46 +0100

Cancer Treatment Centers of America will be First in Country to Offer New Technology from Italy PHILADELPHIA, Nov. 18 (HSMN NewsFeed) -- A radiation breakthrough to treat breast cancer patients in one day, as opposed to the current average of six week... Devices, OncologyHitesys, Novac7, Intraoperative Radiotherapy, IORT, radiotherapy (Source: HSMN NewsFeed)

UCLA researchers create 'fly paper' to capture circulating cancer cells

UCLA Newsroom: Health Sciences — Wed, 18 Nov 2009 16:00:00 +0100

Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor. These cells, known as circulating tumor cells, or CTCs, can provide critical information for examining and diagnosing cancer metastasis, determining patient prognosis, and monitoring the effectiveness of therapies. Metastasis — the most common cause of cancer-related death in patients with solid tumors — is caused by marauding tumor cells that leave the primary tumor site and ride in the bloodstream to set up colonies in other parts of the body. The current gold standard for examining the disease status of tumors is ...

New mammography guidelines unleash storm of controversy

Healthcare IT News — Wed, 18 Nov 2009 15:49:22 +0100

The argument over the right age for women to begin mammograms was pushed to the center of the healthcare reform and technology debate with Monday's release of new guidelines from the U.S. Preventive Services Task Force. New advice from the task force, a government panel of scientists and physicians, calls for skipping screenings for women between the ages of 40 and 49 and beginning routine scans at 50. (Source: Healthcare IT News)

Rethinking Screening Mammography

Medscape Internal Medicine Headlines — Wed, 18 Nov 2009 15:37:33 +0100

What is the controversy about screening mammograms according to a recently published JAMA study? Dr. Andrew Kaunitz discusses if you should still recommend breast cancer screening in this video blog. Medscape Ob/Gyn & Women's Health (Source: Medscape Internal Medicine Headlines)

Breast Cancer Treatment Leaves Patients With Chronic Pain

OncologySTAT What Patients Are Reading — Wed, 18 Nov 2009 13:50:12 +0100

Long after patients complete their treatments for breast cancer, many still experience lingering pain and discomfort. Danish researchers found that nearly half of the breast cancer survivors they surveyed... (Source: OncologySTAT What Patients Are Reading)

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BRCA1 Gene Mutation Linked to Low Oocyte Reserves

OncologySTAT Latest News — Wed, 18 Nov 2009 13:50:10 +0100

ATLANTA (EGMN) - Women with the BRCA1 gene mutation have an increased risk of having low oocyte reserves, according to a first-of-its-kind study of 80 women with breast cancer."We hypothesize that because... (Source: OncologySTAT Latest News)

Kiss Drummer Talks About His Breast Cancer

WDSU.com - Health — Wed, 18 Nov 2009 13:41:57 +0100

Former Kiss drummer Peter Criss speaks about his recent bout with breast cancer. (Source: WDSU.com - Health)

Ex-Kiss Drummer Battled Male Breast Cancer

Health News: CBSNews.com — Wed, 18 Nov 2009 13:13:18 +0100

Cancer Overwhelmingly Associated with Women Strikes 2,000 Men a Year (Source: Health News: CBSNews.com)

Kiss Drummer Reveals Breast Cancer Fight

Wed, 18 Nov 2009 13:04:11 +0100

Former Kiss drummer Peter Criss is speaking out about his recent bout with breast cancer. The rocker known as "Catman" is encouraging other men to get tested as soon as they suspect something might be wrong. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

Invitation to Roche investor science event from SABCS 2009

Roche Investor Update — Wed, 18 Nov 2009 13:00:00 +0100

We kindly invite investors and analysts to participate in a conference call to discuss new clinical data and results presented during the 32nd Annual San Antonio Breast Cancer Symposium, 9-13 December 2009, San Antonio, Texas. (Source: Roche Investor Update)

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Startling New Mammogram Guidelines Incite Debate About Risk, Cost

Health News from Medical News Today — Wed, 18 Nov 2009 13:00:00 +0100

The Washington Post: "Women in their 40s should stop routinely having annual mammograms and older women should cut back to one scheduled exam every other year, an influential federal task force has concluded, challenging the use of one of the most common medical tests" (Stein, 11/17). (Source: Health News from Medical News Today)

Startling New Mammogram Guidelines Incite Debate About Risk, Cost

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 13:00:00 +0100

Annals Of Internal Medicine Publishes New USPSTF Breast Cancer Screening Guidelines

Health News from Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

In an update to its 2002 recommendations, the U.S. Preventive Services Task Force (USPSTF) now recommends against routine breast cancer screening for women under the age of 50. Women between the ages of 40 and 49 at high risk for breast cancer should talk to their doctor about the best time to start regular, biennial screening mammography. (Source: Health News from Medical News Today)

Revised Guidelines Say Most Women Can Begin Mammograms At Age 50

Health News from Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

Most women should begin routine mammograms to screen for breast cancer at age 50, not 40 as previously recommended, according to new guidelines from the U.S. Preventive Services Task Force that aim to reduce harm from overtreatment, the New York Times reports. According to the Times, the new guidelines differ significantly from the task force's last recommendations and from those of other groups. (Source: Health News from Medical News Today)

Revised Guidelines Say Most Women Can Begin Mammograms At Age 50

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

Most women should begin routine mammograms to screen for breast cancer at age 50, not 40 as previously recommended, according to new guidelines from the U.S. Preventive Services Task Force that aim to reduce harm from overtreatment, the New York Times reports. (Source: Breast Cancer News From Medical News Today)

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Annals Of Internal Medicine Publishes New USPSTF Breast Cancer Screening Guidelines

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

Effect of alpha tocopherol acetate in Walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases.

Chemico-Biological Interactions — Wed, 18 Nov 2009 10:22:24 +0100

Authors: Badraoui R, Blouin S, Moreau MF, Gallois Y, Rebai T, Sahnoun Z, Baslé M, Chappard D The pathophysiological changes and the oxidative-antioxidative status were evaluated in the bone microenvironment of rat inoculated with Walker 256/B mammary gland carcinoma cells, and used alpha-tocopherol acetate (ATA) as a countermeasure. Walker 256/B cells were injected into the right femora of aged male rats. Animals were randomized into three groups: 12 rats were injected with saline (control group); 14 rats were injected with Walker 256/B cells (5x10(4)) in the medullar cavity (W256 group); 14 rats were inoculated with Walker 256/B cells and treated with ATA (45mg/kg BW) (W256+ATA group). After 20 days, rats were euthanized and the femurs were radiographed. Micro architectural param...

American Society Of Breast Diseases Continues To Support Annual Mammograms For Women Over 40

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

The Executive Committee of the American Society of Breast Disease issued the following response to changes in breast cancer screening recommendations issued by the United States Preventive Services Task Force on November 16, 2009. The new U.S. Preventive Services Task Force's recommendations on screening mammography, clinical breast exam, and self-examination conflict with the facts. (Source: Breast Cancer News From Medical News Today)

New Combination Therapy Could Deliver Powerful Punch To Breast Cancer

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

A powerful new breast cancer treatment could result from packaging one of the newer drugs that inhibits cancer's hallmark wild growth with another that blocks a primordial survival technique in which the cancer cell eats part of itself, researchers say. (Source: Breast Cancer News From Medical News Today)

New Combination Therapy Could Deliver Powerful Punch To Breast Cancer

Health News from Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

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American Society Of Breast Diseases Continues To Support Annual Mammograms For Women Over 40

Health News from Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

Odontoid metastasis: a potential lethal complication

Journal of Orthopaedics and Traumatology — Wed, 18 Nov 2009 09:28:49 +0100

We describe a 40-year-old woman with a history of breast cancer who presented with neck and shoulder pain of 1 week duration with no neurological deficit. Following clinical examination, radiographs taken of the cervical spine was normal. Radiographs repeated 3 weeks later revealed a large lytic lesion of the odontoid occupying 70–80% of the peg. Further investigation including magnetic resonance imaging and bone scan showed no further spinal lesions. She underwent cyclical radiotherapy with complete resolution of the odontoid peg lesion and clinically was asymptomatic at 2 years. Metastatic lesions of the odontoid are atypical, and this case reinforces the necessity of early detection to evade disastrous consequences. Content Type Journal ArticleCategory Case Rep...

USPSTF Mammography Recommendations Will Result In Countless Unnecessary Breast Cancer Deaths Each Year

Health News from Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

If cost-cutting U.S. Preventive Services Task Force (USPSTF) mammography recommendations are adopted as policy, two decades of decline in breast cancer mortality could be reversed and countless American women may die needlessly from breast cancer each year. (Source: Health News from Medical News Today)

Cytori Completes Enrollment In International Breast Cancer Reconstruction Study; Interim Data To Be Presented Dec. 12

Health News from Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

Cytori Completes Enrollment In International Breast Cancer Reconstruction Study; Interim Data To Be Presented Dec. 12

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

Cytori Therapeutics (NASDAQ:CYTX) completed enrollment in a 70-patient, international breast cancer reconstruction study, RESTORE 2. The study is evaluating the use of cell-enriched fat grafting to restore functional and cosmetic deformities in women who have undergone partial mastectomy for early breast cancer. Interim data on the first 32 patients who have reached the six-month follow-up will be presented as a poster at the San Antonio Breast Cancer Symposium December 12, 2009 at 7 a.m. U. (Source: Breast Cancer News From Medical News Today)

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USPSTF Mammography Recommendations Will Result In Countless Unnecessary Breast Cancer Deaths Each Year

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

Mastectomy not being overused for breast cancer treatment, study suggests

ScienceDaily Headlines — Wed, 18 Nov 2009 07:00:00 +0100

With there being a concern that mastectomy is excessively used as a treatment for breast cancer, a survey of nearly 2,000 women indicates that breast-conserving surgery was attempted as the initial therapy for about 75 percent of those surveyed, according to a new study. (Source: ScienceDaily Headlines)

American Cancer Society admits mammograms and cancer screenings are over-hyped

NaturalNews.com — Wed, 18 Nov 2009 07:00:00 +0100

(NaturalNews) Dr. Otis Brawley, chief medical officer of the American Cancer Society, recently participated in an interview with the New York Times concerning a Journal of the American Medical Association analysis of breast and prostate cancer screening. The study questioned the legitimacy of such screenings in saving lives, a notion confirmed by Dr. Brawley as legitimate. Adding that the supposed benefits of screening have been "exaggerated", Dr. Brawley's comments have fueled a firestorm of controversy since they fly in the face of what the organization has been saying and promoting for years. Cancer screenings essentially have no benefit Prostate-specific antigen (PSA) cancer screenings are considered by many to be ineffective in identifying legitimate cancers and in reducing prostate c...

One in Three Cancers Diagnosed with Free Mammogram Screening Is an "Overdiagnosis"

NaturalNews.com — Wed, 18 Nov 2009 07:00:00 +0100

(NaturalNews) In countries with public breast cancer screening programs, one in every three diagnosed with invasive breast cancers would never have produced symptoms in a patient before she died of other causes, a new study has revealed."Screening for cancer may lead to earlier detection of lethal cancers but also detects harmless ones that will not cause death or symptoms," wrote the researchers, from the Nordic Cochrane Center in Denmark, in the British Medical Journal."The detection of such cancers, which would not have been identified clinically in someone's remaining lifetime, is called overdiagnosis and can only be harmful to those who experience it."Researchers analyzed breast cancer diagnosis rates among both screened unscreened women in Australia, Canada, Norway, Sweden and the Un...

Breast cancer prevention: Lifestyle can reduce risk

MayoClinic.com Full Feed — Wed, 18 Nov 2009 06:00:00 +0100

Breast cancer prevention — More exercise, less alcohol and other measures reduce breast cancer risk. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

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Five common single nucleotide polymorphisms in the PALB2 gene and susceptibility to breast cancer in eastern Chinese population

Breast Cancer Research and Treatment — Wed, 18 Nov 2009 05:22:53 +0100

Abstract Certain rare germline mutations in the PALB2 gene have been confirmed to increase susceptibility to breast cancer in diverse populations, but it has not been very clear that whether some common polymorphic variants in PALB2 also increase breast cancer risk. We conducted a case–control study to validate the association of common variations in the PALB2 gene and breast cancer in eastern Chinese population. A total of six common single nucleotide polymorphisms (rs8053188, rs16940342, rs249954, rs447529, rs249935, and rs3096145), which tagged the known common variants (minor allele frequency >0.1) of PALB2, were genotyped among 660 cases and 756 cancer-free controls by SNPstream assay. Except rs3096145, other five SNPs passed the quality assessment criteria with ...

A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

Breast Cancer Research and Treatment — Wed, 18 Nov 2009 05:22:52 +0100

Abstract MicroRNAs (miRNAs) regulate pathways involved in cell differentiation, proliferation, development, and apoptosis by degradation of target mRNAs and/or repression of their translation. Although the single nucleotide polymorphisms (SNPs) in miRNAs target sites have been studied, the effects of SNPs in miRNAs are largely unknown. In our study, we first systematically sequenced miRNA genes reported to be involved in breast cancer to identify/verify SNPs. We analyzed four SNPs, one located in the pre-miRNA and the other three located in miRNA flanking regions, for a putative association with breast cancer risk. The SNP rs895819, located in the terminal loop of pre-miRNA-27a, showed a protective effect. In a large familial breast cancer study cohort, the rare [G] allele...

Gene promoter methylation is associated with increased mortality among women with breast cancer

Breast Cancer Research and Treatment — Wed, 18 Nov 2009 05:22:51 +0100

Abstract To better understand breast cancer etiology and progression, we explored the association between promoter methylation status of three breast cancer-related genes (BRCA1, APC, and p16) and survival in a large cohort of women with breast cancer. About 800 archived tumor tissues were collected from women diagnosed with a first primary invasive or in situ breast cancer in 1996–1997. The vital status of the participants was followed through the end of year 2005 with a mean follow-up time of 8.0 years. Promoter methylation was assessed by methylation-specific PCR (for BRCA1) and MethyLight (for APC and p16). The association of promoter methylation and breast cancer mortality was evaluated by Cox-proportional hazards models. Methylated promoters were found in 59.0,...

Reciprocal regulation of ZEB1 and AR in triple negative breast cancer cells

Breast Cancer Research and Treatment — Wed, 18 Nov 2009 05:22:51 +0100

Abstract Zinc-finger enhancer binding protein (ZEB1) is a transcription factor involved in the progression of cancer primarily through promoting epithelial to mesenchymal transition (EMT). ZEB1 represses the expression of E-cadherin by binding to E-box sequences in the promoter, thus decreasing epithelial differentiation. We show that ZEB1 and androgen receptor (AR) cross-talk in triple negative breast cancer cell lines. Chromatin immunoprecipitation analysis demonstrates that ZEB1 binds directly to the E-box located in the AR promoter. ZEB1 suppression by stably transfecting shRNA in a triple negative breast cancer cell line resulted in a decrease of AR mRNA, protein, and AR downstream targets. ZEB1 knockdown in triple negative breast cancer cells sensitized the cells to ...

Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

Breast Cancer Research and Treatment — Wed, 18 Nov 2009 05:22:48 +0100

This study showed no evidence for altered risk of breast cancer for individuals with the GSTT1 and GSTM1 deletion variants, but did report that the GSTP1 Ile105Val (rs1695) variant was associated with increased breast cancer risk in carriers. We investigated the association between these three GST polymorphisms and breast cancer risk using existing data from 718 women BRCA1 and BRCA2 mutation carriers from Australia, the UK, Canada, and the USA. Data were analyzed within a proportional hazards framework using Cox regression. There was no evidence to show that any of the polymorphisms modified disease risk for BRCA1 or BRCA2 carriers, and there was no evidence for heterogeneity between sites. These results support the need for replication studies to confirm or refute hypothesis-generatin...

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Prognostic and predictive factors and genetic analysis of early breast cancer

Clinical and Translational Oncology — Wed, 18 Nov 2009 04:59:13 +0100

Abstract The great heterogeneity of breast cancer makes it impossible to firmly predict which patients with early-stage tumours will or will not need systemic treatments according to the conventional prognostic factors currently employed. In fact, a substantial percentage of patients receive medical treatment for a disease that will not relapse, while another proportion of patients regarded as having good prognostic factors according to the classic criteria do not receive treatment and suffer disease relapse. Considering that most oncological treatments have short- and long-term toxic effects, new methods capable of offering a more precise prognosis need to be developed. The individualisation of the diagnosis of patients with breast cancer based on molecular and gene expre...

Targeted therapy of metastatic breast cancer

Clinical and Translational Oncology — Wed, 18 Nov 2009 04:59:07 +0100

Abstract Breast cancer is a heterogeneous disease characterised by a dysregulation of multiple pathways related to cell differentiation, cell cycle control, apoptosis, angiogenesis and development of metastasis. Acting against these pathways provides therapeutic targets for new targeted biologic therapies, which, in the future, might constitute a key for fighting cancer. The development of molecular technology in recent years has allowed a further comprehension of these mutations and dysregulated pathways leading to oncogenesis. New targeted biologic therapies will block essential functions of cancer cells and tumour stroma. A growing number of therapy options, alone or in combination with background treatments (chemotherapy, hormone therapy, radiotherapy), will allow onco...

Breastfeeding reduces breast cancer risk: a case–control study in Tunisia

Cancer Causes and Control — Wed, 18 Nov 2009 04:43:46 +0100

In this report, we examined the relationship between mother’s breastfeeding history and her risk of breast cancer, in a case–control study in Tunisia between 2006 and 2009. About 400 breast cancer cases and 400 controls were included. Cases and controls were interviewed using a standardized structured questionnaire to obtain information on breastfeeding and other risk factors. Mean duration of breastfeeding per child was significantly associated with a reduced risk of breast cancer for women who breastfed for >24 months per child. The OR was 0.46 (95% CI, 0.28–0.76) when compared those who breastfed for <6 months. The test for trend was significant (p = 0.01). A significantly reduced risk of breast cancer was found for those whose lifetime duration of b...

Mammographic Screening and Risk Factors for Breast Cancer

American Journal of Epidemiology — Wed, 18 Nov 2009 04:11:06 +0100

Screening mammography can distort estimated effects in breast cancer risk models due to associations with other risk factors. Mammography information was available in the Nurses’ Health Study from 1988, and 1,815 incident breast cancers were accrued through 2000 among 55,625 women with risk factor data. Logistic models were fit for screening mammography, and inverse probability weighting was used to adjust parameters in an established breast cancer risk model. Approximately 80% of women in each 2-year follow-up period had screening mammograms, which were positively associated with history of benign breast disease, family history of breast cancer, hormone therapy, alcohol use, physical activity, multivitamins, and calcium supplements, and negatively associated with postmenopause, curr...

NCI Statement On Breast Cancer Screening

Health News from Medical News Today — Wed, 18 Nov 2009 01:00:00 +0100

NCI appreciates the U.S. Preventive Services Task Force's careful review and analysis of the evidence regarding breast cancer screening for women at average risk. The take-away message is that each woman needs to consider her individual benefits and risks and discuss them with her health care provider before making a decision on when to start screening mammography and how often to get one. (Source: Health News from Medical News Today)

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NCI Statement On Breast Cancer Screening

Breast Cancer News From Medical News Today — Wed, 18 Nov 2009 01:00:00 +0100

Importance of the development time of isolated bone metastasis in breast cancer

Langenbeck's Archives of Surgery — Wed, 18 Nov 2009 00:08:32 +0100

Conclusion Development time of bone metastasis has no effect on clinical progression, time to progression, and overall survival in breast cancer. Content Type Journal ArticleDOI 10.1007/s00423-009-0561-1Authors Sevim Turanli, Ankara Oncology Education and Research Hospital Department of General Surgery Demetevler 06200 Ankara Turkey Journal Langenbeck's Archives of SurgeryOnline ISSN 1435-2451Print ISSN 1435-2443 (Source: Langenbeck's Archives of Surgery)

Worldwide first experiences with vacuum-assisted closure as alternative treatment method to repair defects of an extended thoracic wall recurrence of breast cancer

Archives of Gynecology and Obstetrics — Wed, 18 Nov 2009 00:08:12 +0100

Conclusion Using vacuum-assisted wound closure one can avoid autologous-tissue treatment in the case of extensive loco-regional recurrences. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1277-8Authors Darius Dian, Ludwig-Maximillians-University Hospital Department of Obstetrics and Gynaecology Munich GermanyVera Bodungen, Ludwig-Maximillians-University Hospital Department of Obstetrics and Gynaecology Munich GermanyIsabelle Himsl, Ludwig-Maximillians-University Hospital Department of Obstetrics and Gynaecology Munich GermanyVisnja Drinovac, Ludwig-Maximillians-University Hospital Department of Obstetrics and Gynaecology Munich GermanyIoannes Mylonas, Ludwig-Maximillians-University Hospital Department of Obstetrics and Gynaecology Munich...

Breast cancer screening: Mammogram recommendation hearings called

OrlandoSentinel: Medical Research — Wed, 18 Nov 2009 00:00:00 +0100

In 1997, a federal committee of medical experts recommended against routine mammograms for women in their 40s, sparking a political uproar that led to congressional hearings and a unanimous Senate vote condemning the findings. Now 12 years later, a... (Source: OrlandoSentinel: Medical Research)

Lehigh Valley health professionals question federal panel's finding that women under 50 don't need regular breast cancer screenings

OrlandoSentinel: Medical Research — Wed, 18 Nov 2009 00:00:00 +0100

''I think it's more important if it's in your family history. I'm not on the high-risk end.'' Susan Palmer 43, of Easton ''Insurance companies without a doubt are going to say they're not going to pay for it.'' Marilyn Burgess 51, of Bethlehem... (Source: OrlandoSentinel: Medical Research)

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Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community setting

Breast Cancer Research — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions: The marked increase in the 1990s in the use of adjuvant therapy for DCIS patients treated with BCS in the community setting only partially explains the 50% decline in risk of recurrence risk. Changes in pathology factors have likely also contributed to this decline. (Source: Breast Cancer Research)

Boehringer Ingelheim and GlaxoSmithKline back EFA`s call for urgent improvements in care for people with lung disease this World COPD Day

Boehringer Ingelheim RSS-Newsfeed — Wed, 18 Nov 2009 00:00:00 +0100

Brussels, Ingelheim and London, 18 November 2009 - Boehringer Ingelheim and GSK, companies with a strong heritage in COPD (chronic obstructive pulmonary disease) and a commitment to improved patient care, have today announced their support of The European Federation of Allergy and Airways Diseases Patients` Associations` (EFA) call for urgent improvement in the care of people with COPD. To coincide with World COPD Day 2009, EFA has published a comprehensive overview of COPD in Europe, the EFA Book on COPD in Europe: Sharing and Caring which highlights local successes and serious shortfalls in the way the disease is diagnosed and managed. COPD is a chronic lung disease associated with a high level of mortality. According to the latest World Health Orgainzation (WHO) estimates, 210 millio...

Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death

Breast Cancer Research — Wed, 18 Nov 2009 00:00:00 +0100

The high rate of glucose utilization by cancer cells has been well characterized. Recent data suggest that when normal mammary epithelial cells are cultured under nonadherent conditions, glucose consumption decreases, ATP levels fall, and concentrations of reactive oxygen species rise. The rise in reactive oxygen species causes death of nonadherent cells, which can be suppressed with antioxidants. Nonadherent ErbB2-transformed mammary epithelial cells maintain glucose transport and antioxidant production; however, antioxidants appear to enhance anchorage-independent growth. These findings integrate aspects of glucose metabolism, anoikis suppression and antioxidant production in tumor cell biology and suggest that antioxidant therapy could stimulate tumor survival. (Source: Breast Cancer Re...

Novel Strategies for Bone-Directed Therapy Across the Cancer Continuum

Clinical Care Options Oncology - Breast Cancer — Wed, 18 Nov 2009 00:00:00 +0100

CCO Slideset - Download slides from the independent symposium presented for attendees of the IX International Meeting on Cancer-Induced Bone Disease by Allan Lipton, MD; Robert E. Coleman, MD, FRCP; G. David Roodman, MD, PhD; and Matthew R. Smith, MD, PhD on October 29, 2009. (Source: Clinical Care Options Oncology - Breast Cancer)

Applications submitted to FDA for bevacizumab (Avastin®) in first-line treatment of metastatic breast cancer

NeLM - Oncology — Wed, 18 Nov 2009 00:00:00 +0100

Source: BioSpace Area: News According to BioSpace, Genentech has submitted two supplemental Biologics License Applications (sBLAs) to the U.S. FDA for bevacizumab (Avastin®) for the first-line treatment of women with advanced (metastatic) HER2-negative breast cancer. One sBLA is based on the Phase III AVADO study that compared bevacizumab in combination with docetaxel chemotherapy, to docetaxel alone in this setting. The other is based on the Phase III RIBBON 1 study that investigated bevacizumab in combination with a taxane, anthracycline-based or capecitabine chemotherapy (compared with the chemotherapies alone). Both studies met their primary endpoints of improving progression-free survival. Data from AVADO and RIBBON 1 are being submitted as part of Genentech's ...

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Results of the first phase 1 clinical trial of the HER-2/neu peptide (GP2) vaccine in disease-free breast cancer patients

Cancer — Wed, 18 Nov 2009 00:00:00 +0100

HER-2/neu, overexpressed in breast cancer, is a source of immunogenic peptides that include GP2 and E75. Phase 2 testing of E75 as an adjuvant vaccine has suggested a clinical benefit. GP2, derived from the transmembrane portion of HER-2/neu, has differing binding characteristics and may be more immunogenic than E75. Results of the first phase 1 trial of GP2 peptide vaccine are presented.Disease-free, lymph node-negative, human leukocyte antigen (HLA)-A2+ breast cancer patients were enrolled. This dose escalation trial included 4 groups to determine safety and optimal GP2 peptide/granulocyte-macrophage colony-stimulating factor (GM-CSF) dose. Toxicities were monitored. Immunologic response was assessed ex vivo via the HLA-A2:immunoglobulin dimer assay to detect GP2-specific CD8+ T cells (a...

Longitudinal change of treatment-related upper limb dysfunction and its impact on late dysfunction in breast cancer survivors: A prospective cohort study

Journal of Surgical Oncology — Wed, 18 Nov 2009 00:00:00 +0100

To investigate the prevalence of upper limb dysfunction (ULD) and subtypes after breast cancer surgery and to identify factors associated with late ULD.Among 191 enrolled patients, 191 were evaluated at 3 months, 187 at 6 months, and 183 at 12 months after surgery. Pain, shoulder range of motion, muscle strength, and arm circumference were assessed. Based on symptoms and physical examinations, the types of ULD common after breast cancer treatment were diagnosed and categorized.The prevalence of ULD after surgery were 24.6%, 20.9%, and 26.8% at 3, 6, and 12 months, respectively. The most common types of ULD were pectoralis tightness at 3 and 6 months and lymphedema at 12 months. Patients with pectoralis tightness or lymphedema at 3 or 6 months showed a higher prevalence of rotator cuff dise...

Annual Screening Mammography Continues to be Recommended in Updated NCCN Guidelines for Breast Cancer Screening and Diagnosis

National Comprehensive Cancer Network — Wed, 18 Nov 2009 00:00:00 +0100

November 16, 2009 FORT WASHINGTON, PA — The National Comprehensive Cancer Network (NCCN) recently updated the NCCN Clinical Practice Guidelines in Oncology™ for Breast Cancer Screening and Diagnosis and continues to recommend annual clinical breast examinations and mammography for women 40 years and older at normal risk. “For women age 40 and over, the benefits of annual breast screening continue to outweigh the risks,” says Therese B. Bevers, MD, of the... (Source: National Comprehensive Cancer Network)

UCSF Experts Weigh In on New Guidelines for Breast Cancer Screening

UCSF Medical Center — Wed, 18 Nov 2009 00:00:00 +0100

Following a major reversal on breast cancer screening recommendations, several UCSF experts are hopeful that future prevention efforts will focus less on one-size-fits-all care and more on individualized risk assessment. (Source: UCSF Medical Center)