MedWorm: Breast Cancer

Nonprofits' Backers Mobilize

WSJ.com: Health — Fri, 03 Feb 2012 03:10:56 +0100

The Susan G. Komen for the Cure breast-cancer charity grappled with the fallout from its decision to cut funding for Planned Parenthood affiliates, as both groups saw a surge in donations. (Source: WSJ.com: Health)

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Komen struggles to defuse Planned Parenthood crisis

Reuters: Health — Fri, 03 Feb 2012 00:01:37 +0100

WASHINGTON (Reuters) - The world's leading breast cancer charity, Susan G. Komen for the Cure, struggled on Thursday to defuse a growing crisis over its decision to cut funding for Planned Parenthood, which provides abortion and birth control services. (Source: Reuters: Health)

Breast Cancer Action donations surge after Komen-Planned Parenthood fiasco

bizjournals.com Health Care:Pharmaceuticals headlines — Thu, 02 Feb 2012 23:32:25 +0100

Believe it or not, there is a beneficiary of the controversial decision by Susan G. Komen for the Cure to not continue funding breast cancer screening at Planned Parenthood centers. San Francisco-based Breast Cancer Action saw donations from its recent email alerts surge 30-fold from the average volume of click-throughs from the alerts, said spokeswoman Angela Wall. It sent out two alerts Wednesday about the change in Komen’s grant process, which Planned Parenthood has charged was based on pressure from antiabortion activists, and how the change affects Planned Parenthood... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Komen move on Planned Parenthood sparks abortion row

Reuters: Health — Thu, 02 Feb 2012 21:39:47 +0100

WASHINGTON (Reuters) - A decision by Susan G. Komen for the Cure to cut funding for Planned Parenthood erupted into a crisis over abortion rights on Thursday, fueling an angry public debate about the future of the leading breast cancer charity. (Source: Reuters: Health)

Komen charity denies abortion pressure in funding shift

Reuters: Health — Thu, 02 Feb 2012 19:20:44 +0100

WASHINGTON (Reuters) - Breast cancer charity Susan G. Komen for the Cure on Thursday denied political pressure from anti-abortion groups had anything to do with its decision to cut off funding for the Planned Parenthood Federation of America, trying to contain a crisis between the two leading women's health groups. (Source: Reuters: Health)

Dropping Planned Parenthood Is Not Political, Says Susan G. Komen For The Cure

Health News from Medical News Today — Thu, 02 Feb 2012 17:00:00 +0100

Breast cancer charity, Susan G. Komen for the Cure, says that dropping Planned Parenthood from its granting process is not political, and says it is "dismayed and extremely disappointed" that its action has been mischaracterized. The charity says it has taken actions to make its granting process stronger and more effective, resulting in Planned Parenthood being dropped from its list of grantees. In a written communiquÃ© today, Komen says it embarked on a new initiative in 2010 to assess the impact of its community grants... (Source: Health News from Medical News Today)

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Video: Komen charity cuts off Planned Parenthood

Health News: CBSNews.com — Thu, 02 Feb 2012 14:22:07 +0100

Susan G. Komen for the Cure, a leading force in the fight against breast cancer, is being heavily criticized for cutting its ties to Planned Parenthood. CBS News Congressional correspondent Nancy Cordes reports. (Source: Health News: CBSNews.com)

Reactions heated to Planned Parenthood-Komen rift

CTV Health — Thu, 02 Feb 2012 13:26:42 +0100

Planned Parenthood said Wednesday that it received more than $400,000 from 6,000 donors in the 24 hours after news broke that its affiliates would be losing grants for breast screenings from the Susan G. Komen for the Cure breast-cancer foundation. (Source: CTV Health)

Recommended Breast Screening MRI Not Followed Through

Health News from Medical News Today — Thu, 02 Feb 2012 09:00:00 +0100

A study of 64,659 women, recently published in the journal Academic Radiology, found that while 1,246 of these women were at high enough breast cancer risk to recommend additional screening with MRI, only 173 of these women returned to the clinic within a year for the additional screening. "It's hard to tell where, exactly, is the disconnect," says Deborah Glueck, PhD, investigator at the University of Colorado Cancer Center and associate professor of biostatistics and informatics at the Colorado School of Public Health, the paper's senior author... (Source: Health News from Medical News Today)

breastfeeding and breast cancer

About.com Breast Cancer — Thu, 02 Feb 2012 05:00:00 +0100

Although it is unusual to be diagnosed with breast cancer right after becoming a new mom and starting to breastfeed, it does happen. So how does this affect your plans to breastfeed? (Source: About.com Breast Cancer)

Uproar as Komen Foundation Cuts Money to Planned Parenthood

NYT Health — Thu, 02 Feb 2012 04:47:19 +0100

Two organizations dedicated to detecting and curing breast cancer have found themselves on opposite sides of the nation’s divisive debate over abortion. (Source: NYT Health)

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Are we treating the elderly with breast cancer to the same standard as younger patients?

Future Medicine: Aging Health — Thu, 02 Feb 2012 04:00:13 +0100

Aging Health , February 2012, Vol. 8, No. 1, Pages 1-3. (Source: Future Medicine: Aging Health)

Charity pulls plug on Planned Parenthood, inciting critics

USATODAY.com Health — Thu, 02 Feb 2012 01:11:39 +0100

Susan G. Komen for the Cure, the breast cancer awareness foundation known for its pink ribbon, has critics seeing red. (Source: USATODAY.com Health)

Exercise a Good Pick-Me-Up After Cancer Treatment: Study

Cancercompass News: Breast Cancer — Thu, 02 Feb 2012 00:00:00 +0100

Aerobic, resistance and strength training improved weight and well-being (Source: Cancercompass News: Breast Cancer)

Faith voices cheer Planned Parenthood cut off

USATODAY.com Health — Wed, 01 Feb 2012 20:22:00 +0100

Faith voices cheered Susan G. Komen Foundation's cutoff of funds for breast cancer screening at 19 Planned Parenthood affiliates. (Source: USATODAY.com Health)

Breast Cancer Surgery Often Repeated To Take Out More Tissue

Health News from Medical News Today — Wed, 01 Feb 2012 19:00:00 +0100

22.9% of breast cancer patients who undergo partial mastectomies need further operations to remove more tissue, researchers reported in JAMA (Journal of the American Medical Association). The authors, from Michigan State University, added that rates of reexcision vary considerably between surgeons and clinics/hospitals; this variation does not appear to be caused by patients' clinical characteristics. "Excision" means the surgical removal of something, which in this text means a tumor. "Reexcision" means additional surgery in the same area... (Source: Health News from Medical News Today)

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Repeat breast cancer surgery rates vary widely: Why?

Health News: CBSNews.com — Wed, 01 Feb 2012 17:20:23 +0100

Is a second - or third - breast cancer surgery really necessary? New study raises questions (Source: Health News: CBSNews.com)

Video: Breast cancer surgeries: Are they always necessary?

Health News: CBSNews.com — Wed, 01 Feb 2012 16:39:13 +0100

A new study finds that nearly one-in-four women with breast cancer have more than one surgery. Dr. Rache Simmons, chief of breast surgery at NY-Presbyterian Hospital/Weill Cornell Medical Center, talks to Gayle King and Erica Hill about how the number of surgeries could be reduced. (Source: Health News: CBSNews.com)

Health Highlights: Feb. 1, 2012

Primary Care News - Doctors Lounge — Wed, 01 Feb 2012 16:03:00 +0100

Ground Beef-Related Salmonella Outbreak Over: CDC ALS Researcher Dies of Disease He Studied Breast Cancer Charity Severs Ties With Planned Parenthood Study Identifies New Location for Brain Speech Center Indoor Tanning Salons Lie About Health Risks: Investigation (Source: Primary Care News - Doctors Lounge)

Protein structures give disease clues

EurekAlert! - Medicine and Health — Wed, 01 Feb 2012 05:00:00 +0100

(University of California - Davis) Discoveries about the shape and structure of biological molecules could potentially lead to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. (Source: EurekAlert! - Medicine and Health)

Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

BMC Cancer — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: uPA and PAI-1 concentrations in ND were higher in women with atypia and cancer compared to women with benign disease. Combining uPA, PAI-1 and TF in the assessment of women requiring diagnostic breast surgery maximized disease prediction. The assessment of these markers may prove useful in early breast cancer detection. (Source: BMC Cancer)

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Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion

BMC Cancer — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: miR-133a expression was lost in breast cancer tissues, loss of which was associated with lymph nodes metastasis, high clinical stages and shorter relapse-free survivals of patients with breast cancer. Functionally, miR-133a can suppress tumor cell invasion and migration and targeted the expression of FSCN1. Future study will verify whether detection of miR-133a expression can served as a novel biomarker for breast cancer progression and patient prognosis. (Source: BMC Cancer)

Association between breast cancer and allostatic load by race: National Health and Nutrition Examination Survey 1999–2008

Psycho-Oncology — Wed, 01 Feb 2012 05:00:00 +0100

[Comment] Don't pick the loser: lessons from the GeparQuinto trial

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

In The Lancet Oncology, Michael Untch and colleagues report the first efficacy results from the GeparQuinto (GBG 44) study, a randomised phase 3 trial of lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-based and taxane-based chemotherapy. 620 women with HER2-positive operable or locally advanced breast cancer were randomly assigned to receive lapatinib (a tyrosine-kinase inhibitor of HER1 and HER2) or trastuzumab (a monoclonal antibody to the HER2 receptor), concurrent with a planned regimen of four cycles of an anthracycline (epirubicin 90 mg/m2 plus cyclophosphamide 600 mg/m2) followed by four cycles of a taxane (docetaxel 100 mg/m2). (Source: The Lancet Oncology)

[Comment] VEGF Trap for the treatment of malignant ascites

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

About 10% of all cases of ascites are caused by a malignant disease. In developed countries the most common neoplasm associated with ascites is ovarian cancer. The pathophysiology of malignant ascites is multifactorial, and its molecular pathogenesis is only poorly understood. Ascites formation can result from obstruction of lymph vessels by tumour cells, resulting in incomplete absorption of intraperitoneal fluid and protein, especially in patients with lymphoma or breast cancer. Since malignant ascites is usually an exsudate with a high protein concentration, an increased vascular permeability has been implicated in its pathogenesis. (Source: The Lancet Oncology)

[News] US veterans hospitals lack mammography services

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

A sixth of US soldiers are women and they are the fastest growing population served by the US Department of Veterans Affairs (VA), however, most VA hospitals do not offer breast cancer screening or many other women's health services. (Source: The Lancet Oncology)

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[Cancer and Society] The SCAR project: compassion through reality

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

The Pulitzer prize nominated Surviving Cancer: Absolute Reality (SCAR) project is billed as an exhibition to raise awareness of early-onset breast cancer, and it easily achieves this goal. However, an added gravity arises as one wanders through the chilling, 6 feet high portraits of young breast cancer survivors. Aged between 18 and 35 years, these women outwardly display the scars and wounds of their treatment, but deeper metaphors are etched in each photograph. Each represents the story of the devastation of breast cancer in early adulthood, and challenges viewers to re-examine their own lives as a result. (Source: The Lancet Oncology)

The Longitudinal Relationship between Fatigue and Sleep in Breast Cancer Patients Undergoing Chemotherapy

Sleep — Wed, 01 Feb 2012 03:52:03 +0100

Conclusion:Fatigue was significantly associated with subjective reports of poor sleep and objective measures of daytime sleepiness, but not with nocturnal sleep as measured with actigraphy. This relationship between fatigue and sleep warrants further studies to explore their possible common underlying etiology.Citation:Liu L; Rissling M; Natarajan L; Fiorentino L; Mills PJ; Dimsdale JE; Sadler GR; Parker BA; Ancoli-Israel S. The longitudinal relationship between fatigue and sleep in breast cancer patients undergoing chemotherapy. SLEEP 2012;35(2):237-245. (Source: Sleep)

Cancer Group Halts Financing to Planned Parenthood

NYT Health — Wed, 01 Feb 2012 03:48:13 +0100

Susan G. Komen for the Cure was accused of bowing to right-wing pressure in its decision. (Source: NYT Health)

Breast cancer charity ends Planned Parenthood funding

Reuters: Health — Wed, 01 Feb 2012 02:01:26 +0100

(Reuters) - Planned Parenthood said on Tuesday that the leading U.S. breast-cancer charity would no longer provide new funding to the group, which performs abortions and other services at clinics around the country. (Source: Reuters: Health)

Cancer charity halts grants to Planned Parenthood

USATODAY.com Health — Tue, 31 Jan 2012 23:27:45 +0100

The nation's leading breast-cancer charity, Susan G. Komen for the Cure, is halting its financial partnerships with numerous Planned Parenthood ... (Source: USATODAY.com Health)

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Cancer charity halts Planned Parenthood grants

Health News: CBSNews.com — Tue, 31 Jan 2012 22:36:32 +0100

Susan G. Komen for the Cure breast cancer charity and Planned Parenthood in a bitter rift over abortion debate (Source: Health News: CBSNews.com)

Second Breast Cancer Surgery Sometimes Needed

The Doctors Lounge - Oncology — Tue, 31 Jan 2012 22:00:00 +0100

After a partial mastectomy, almost one in four women requires re-excision, study finds (Source: The Doctors Lounge - Oncology)

Repeat Breast Cancer Surgery Guidelines Found Unclear

NYT Health — Tue, 31 Jan 2012 21:29:37 +0100

A study suggests that some lumpectomy patients undergo second operations that they do not need and others might need surgery that they do not get. (Source: NYT Health)

Re-Operation Common After Breast-Conserving Surgery

MedlinePlus Health News — Tue, 31 Jan 2012 21:25:19 +0100

One in four women who have breast-conserving surgery for cancer needs a second operation to remove more breast tissue, suggests a new study that also found the rate of re-operation varied widely by surgeon.Source: Reuters Health Related MedlinePlus Pages: Breast Cancer, Surgery (Source: MedlinePlus Health News)

Lumpectomy Often Not End of Story (CME/CE, with video)

MedPage Today Hematology/Oncology — Tue, 31 Jan 2012 21:12:12 +0100

(MedPage Today) -- Almost a quarter of breast cancer lumpectomies are followed by revision surgery, although that rate varies widely across surgeons and centers. (Source: MedPage Today Hematology/Oncology)

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1 in 4 Partial Mastectomy Patients Have Second Surgery

WebMD Health — Tue, 31 Jan 2012 20:17:01 +0100

Close to 1 in 4 breast cancer patients who have partial mastectomies undergo a second surgery to remove suspicious tissue, but there is little agreement about when the second surgery is needed. (Source: WebMD Health)

The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

Molecular Carcinogenesis — Tue, 31 Jan 2012 14:40:24 +0100

AbstractThe prevalence of obesity, an established risk and progression factor for postmenopausal breast cancer, remains high in US women. Activation of Akt/mammalian target of rapamycin (mTOR) signaling plays a key role in the obesity–breast cancer link. However, the impact of weight normalization in obese postmenopausal women on breast tumorigenesis and/or Akt/mTOR activation is poorly characterized. To model this, ovariectomized female C57BL/6 mice were fed a control diet (n = 20), a calorie restriction (CR) regimen (n = 20), or a diet‐induced obesity (DIO) diet (n = 30). At week 17, DIO mice were switched to control diet, resulting in formerly obese (FOb) mice with weights identical to the controls by week 20. MMTV‐Wnt‐1 mammary tumor cells were injected at 20 wk i...

HER-2 breast cancer may benefit from lapatinib/trastuzumab combination therapy

HemOncToday.com — Tue, 31 Jan 2012 14:00:00 +0100

Baselga J. Lancet. 2012;doi:10.1016/S0140-6736(11)61847-3. (Source: HemOncToday.com)

Spatial Analysis of County-Level Breast Cancer Mortality in Texas

International Journal of Photoenergy — Tue, 31 Jan 2012 11:10:23 +0100

Conclusions. Highest rates of female breast cancer mortality in Texas have shifted over time from southeastern areas towards northern and eastern areas, and breast cancer mortality at the county level is distributed heterogeneously based on racial/ethnic status. Non-Hispanic blacks were at highest risk in the northeastern region and lowest risk in the southern region, while Hispanics were at highest risk in the southern region along the border with Mexico and lowest risk in the northeastern region. (Source: International Journal of Photoenergy)

Nigeria: Breast Cancer - MWAN Seeks Inclusion of Bse Technique in Schools

AllAfrica News: Health and Medicine — Tue, 31 Jan 2012 10:25:56 +0100

Vanguard (Lagos)-Federal government has been urged to include technique of Breast Self Examination into the school curriculum. The Medical Women's Association of Nigeria, MWAN, in a communiqué issued after it's 17th Biennial Scientific Conference and General Assembly in Lagos tagged; "Revisiting the myth behind Maternal and Infant Mortality: Can e-health/m-Health Make a Difference" noted that all females from JSS3 or at menarche should be proficient in the technique of Breast Self Examination, BSE. (Source: AllAfrica News: Health and Medicine)

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Women not following through with recommended breast screening MRI

EurekAlert! - Medicine and Health — Tue, 31 Jan 2012 05:00:00 +0100

(University of Colorado Denver) A study of 64,659 women, recently published in the journal Academic Radiology, found that while 1,246 of these women were at high enough breast cancer risk to recommend additional screening with MRI, only 173 of these women returned to the clinic within a year for the additional screening. (Source: EurekAlert! - Medicine and Health)

Rate of follow-up surgeries after partial mastectomy varies greatly

EurekAlert! - Medicine and Health — Tue, 31 Jan 2012 05:00:00 +0100

(Michigan State University) A new study reveals substantial differences -- by both surgeon and institution -- in the rates of follow-up surgeries for women who underwent a partial mastectomy for treatment of breast cancer.Those differences, which cannot be explained by a patient's medical or treatment history, could affect both cancer recurrence and overall survival rates, according to the study led by Laurence McCahill of Michigan State University. (Source: EurekAlert! - Medicine and Health)

Do we need biomarkers to predict the benefit of adding adjuvant taxanes for treatment of breast cancer?

Breast Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

The current understanding of the molecular biology of breast cancer presents an extremely complex portrait of the disease. Based on this knowledge, considerable efforts are being made to identify biomarkers that will predict the response to a specific treatment while minimizing the risk of unnecessary side effects. In breast cancer, the Ki67 index has been associated with poor prognosis and might play a relevant role in predicting benefit from adjuvant docetaxel, as observed in the article accompanying this editorial. Taxanes are one of the most active cytotoxic agents for breast cancer. However, the role of taxane-based chemotherapy as adjuvant treatment of early breast cancer remains controversial in some subsets of patients. For this reason, the Ki67 index might help to better define th...

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system

Breast Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions: P-I is safe and effective against breast cancer. Liposomal formulation enhances its efficacy; its effect is heavily dependent on the induction of oxidative stress and the suppression of the thioredoxin system. P-I merits further evaluation as an agent for the treatment of breast cancer. (Source: Breast Cancer Research)

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Study finds substantial variability in rate of additional surgery after partial mastectomy

EurekAlert! - Cancer — Tue, 31 Jan 2012 05:00:00 +0100

(JAMA and Archives Journals) Nearly one in four women who undergo a partial mastectomy for treatment of breast cancer have another surgery to remove additional tissue (reexcision), and there is substantial surgeon and institutional variation in the rate of reexcisions that cannot be explained by patients' clinical characteristics, according to a study in the Feb. 1 issue of JAMA. (Source: EurekAlert! - Cancer)

Clinical significance of CD151 overexpression in subtypes of invasive breast cancer

British Journal of Cancer AOP — Tue, 31 Jan 2012 05:00:00 +0100

Authors: M J Kwon, S Park, J Y Choi, E Oh, Y J Kim, Y-H Park, E Y Cho, M J Kwon, S J Nam, Y-H Im, Y K Shin & Y-L Choi (Source: British Journal of Cancer AOP)

Breast cancer: increasing therapy options for HER2-positive early breast cancer

Nature Clinical Practice Oncology — Tue, 31 Jan 2012 05:00:00 +0100

Nature Reviews Clinical Oncology 9, 66 (2012). doi:10.1038/nrclinonc.2011.214 Author: Nadia Harbeck Harbeck, N. Nat. Rev. Clin. Oncol.9, 10–12 (2012); doi:10.1038/nrclinonc.2011.193In the version of this article initially published online the author's name in the citation line was spelled incorrectly. The error has been corrected for the (Source: Nature Clinical Practice Oncology)

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpressed in invasive estrogen receptor (ER)α-negative breast cancers. However, it has not been established whether S100A7 contributes to breast cancer growth or metastasis. Here, we report the consequences of its expression on inflammatory pathways that impact breast cancer growth. Overexpression of human S100A7 or its murine homologue mS100a7a15 enhanced cell proliferation and upregulated various proinflammatory molecules in ERα-negative breast cancer cells. To examine in vivo effects, we generated mice with an inducible form of mS100a7a15 (MMTV-mS100a7a15 mice). Orthotopic implantation of MVT-1 breast tumor cells into the mammary glands of these mice enhanced tumor growth and metastasis. Compared with u...

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

We examined 15 urinary estrogens/estrogen metabolites and breast cancer risk among premenopausal women in a case–control study nested within the Nurses' Health Study II (NHSII). From 1996 to 1999, urine was collected from 18,521 women during the mid-luteal menstrual phase. Breast cancer cases (N = 247) diagnosed between collection and June 2005 were matched to two controls each (N = 485). Urinary estrogen metabolites were measured by liquid chromatography-tandem mass spectrometry and adjusted for creatinine level. Relative risks (RR) and 95% confidence intervals (CI) were estimated by multivariate conditional logistic regression. Higher urinary estrone and estradiol levels were strongly significantly associated with lower risk (top vs. bottom quartile RR: estrone = 0.52; 95% CI, 0.30–0...

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Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that promotes breast cancer progression by diverse mechanisms that remain somewhat unclear. Here we report pharmacologic evidence of a critical role for sphingosine kinase 1 (SphK1) in producing S1P and mediating tumor-induced hemangiogenesis and lymphangiogenesis in a murine model of breast cancer metastasis. S1P levels increased both in the tumor and the circulation. In agreement, serum S1P levels were significantly elevated in stage IIIA human breast cancer patients, compared with age/ethnicity-matched healthy volunteers. However, treatment with the specific SphK1 inhibitor SK1-I suppressed S1P levels, reduced metastases to lymph nodes and lungs, and decreased overall tumor burden of our murine model. Both S1P and a...

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

In this study, we developed and evaluated small molecule inhibitors of Taspase1 as a new candidate class of therapeutic modalities. Genetic deletion of Taspase1 in the mouse produced no overt deficiencies, suggesting the possibility of a wide therapeutic index for use of Taspase1 inhibitors in cancers. We defined the peptidyl motifs recognized by Taspase1 and conducted a cell-based dual-fluorescent proteolytic screen of the National Cancer Institute diversity library to identify Taspase1 inhibitors (TASPIN). On the basis of secondary and tertiary screens the 4-[(4-arsonophenyl)methyl]phenyl] arsonic acid NSC48300 was determined to be the most specific active compound. Structure–activity relationship studies indicated a crucial role for the arsenic acid moiety in mediating Taspase1 inhibi...

Long‐term effect of the self‐management comprehensive coping strategy program on quality of life in patients with breast cancer treated with high‐dose chemotherapy

Psycho-Oncology — Tue, 31 Jan 2012 05:00:00 +0100

ConclusionsThe CCSP improved QOL for patients at 1‐year follow‐up. Patients overwhelmingly reported that CCSP was beneficial. The CCSP as an effective coping intervention has potential as a self‐management program for breast cancer survivors. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

New approach to analyze genetic and clinical data in bisphosphonate‐induced osteonecrosis of the jaw

Oral Diseases — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion: The statistical approach applying PCA to our data may contribute to the better understanding of factors playing role in the development of bisphosphonate‐induced ONJ.© 2012 John Wiley & Sons A/S (Source: Oral Diseases)

Variability in Reexcision Following Breast Conservation Surgery [Original Contribution]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion Substantial surgeon and institutional variation were observed in reexcision following partial mastectomy in women with invasive breast cancer. (Source: JAMA)

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The Challenge of Developing Quality Measures for Breast Cancer Surgery [Editorial]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

(Source: JAMA)

Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587. [Letters]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

(Source: JAMA)

Patient-Centered Care Model Demands Better Physician-Patient Communication [Medical News & Perspectives]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

(Source: JAMA)

Breast cancer vaccine called promising

Health News - UPI.com — Tue, 31 Jan 2012 03:50:56 +0100

PHILADELPHIA, Jan. 30 (UPI) -- A vaccination made using a patient's own cells triggers tumor eradication in nearly 20 percent of those with one type of breast cancer, U.S. researchers said. (Source: Health News - UPI.com)

Second Breast Cancer Surgery Sometimes Needed

Cancercompass News: Breast Cancer — Tue, 31 Jan 2012 00:00:00 +0100

After a partial mastectomy, almost one in four women requires re-excision, study finds (Source: Cancercompass News: Breast Cancer)

Intraoperative Radiation Therapy

Cancercompass News: Breast Cancer — Tue, 31 Jan 2012 00:00:00 +0100

For selected patients IORT provides quick and precisely targeted treatment. (Source: Cancercompass News: Breast Cancer)

Pregnant with Cancer

Cancercompass News: Breast Cancer — Tue, 31 Jan 2012 00:00:00 +0100

Women who are diagnosed with cancer during pregnancy carry a precious burden. (Source: Cancercompass News: Breast Cancer)

BPA and the Single, Spacey, Sex-Starved Male

Psychology Today Sex Center — Mon, 30 Jan 2012 21:27:46 +0100

Among the many subtle evils of BPA, a chemical used in food packaging, is its effect on manhood. What is it doing on a societal level? read more (Source: Psychology Today Sex Center)

Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy

Breast Cancer Research and Treatment — Mon, 30 Jan 2012 16:07:44 +0100

Abstract Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor receptor 2 (Her-2). They are neither susceptible to endocrine therapy nor to a therapy using the anti-Her-2 antibody, trastuzumab. Therefore, an efficient targeted therapy is warranted. Triple-negative breast tumors frequently express membrane bound estrogen receptor G-protein coupled receptor (GPR30). As proof of principle, we analyzed the consequences of a knock-down of GPR30 expression on the growth regulation of triple-negative breast cancer cell lines. Cells of triple-negative breast cancer cell lines were transfected with siRNA against GPR30 or control siRNA, and cell growth was stimulated either with 10−9 M 17β-estr...

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Identification of distinct subgroups of breast cancer patients based on self-reported changes in sleep disturbance

Supportive Care in Cancer — Mon, 30 Jan 2012 16:06:02 +0100

Conclusions A high percentage of women has significant sleep disturbance prior to surgery that persists during subsequent treatments (i.e., radiation therapy and chemotherapy). Clinicians need to perform routine assessments and initiate appropriate interventions to improve sleep prior to and following surgery. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00520-012-1381-3Authors Christina Van Onselen, Department of Physiological Nursing, School of Nursing, University of California, 2 Koret Way-N631Y, San Francisco, CA 94143-0610, USABruce A. Cooper, Department of Physiological Nursing, School of Nursing, University of California, 2 Koret Way-N631Y, San Francisco, CA 94143-0610, USAKathryn Lee, Department of Physiological Nursing, School ...

Meetings

International Journal of Radiation Oncology * Biology * Physics — Mon, 30 Jan 2012 09:33:54 +0100

March 3-4, 2012 3rd Asian Breast Cancer Congress (Source: International Journal of Radiation Oncology * Biology * Physics)

In Regard to “Breast Cancer Recurrent on Supraclavicular Node(s): What Is the Treatment?” (Int J Radiat Oncol Biol Phys 2011;80:1453–1457)

International Journal of Radiation Oncology * Biology * Physics — Mon, 30 Jan 2012 09:33:53 +0100

To the Editor: In a recent issue of this journal, Reddy et al. reported encouraging overall survival data after isolated supraclavicular nodal recurrence (ISNR) in breast cancer patients previously submitted to mastectomy and doxorubicin-based chemotherapy with or without irradiation. The prognosis of ISNR is generally poor: it has been shown that patients have a 5-year survival rate ranging between 5% and 35% . Reddy et al. reported that at the time of relapse the treatment was principally oriented to systemic therapy, whereas an “aggressive local approach” was delivered in only 6 patients, 3 of whom received radiation. In this retrospective analysis the authors observed an overall 3-year survival rate of 49%, with a 3-year distant metastasis–free survival rate of 40% in 47 patien...

Validating Fiducial Markers for Image-Guided Radiation Therapy for Accelerated Partial Breast Irradiation in Early-Stage Breast Cancer

International Journal of Radiation Oncology * Biology * Physics — Mon, 30 Jan 2012 09:33:53 +0100

Conclusion: Fiducial markers are stable throughout the course of APBI. Planning target volume margins when using bony landmarks should be 10 mm and can be reduced to 6 mm if using fiducials. (Source: International Journal of Radiation Oncology * Biology * Physics)

Accuracy Of Mammogram Readings Improved With Visual Nudge

Health News from Medical News Today — Mon, 30 Jan 2012 08:00:00 +0100

In 2011 - to the consternation of women everywhere - a systematic review of randomized clinical trials showed that routine mammography was of little value to younger women at average or low risk of breast cancer. The review showed, for example, that for every 50-year-old woman whose life is prolonged by mammography, dozens are treated unnecessarily - some with harmful consequences - or treated without benefit. Hundreds are told they have breast cancer when they do not. Cindy M... (Source: Health News from Medical News Today)

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Pre-op MRI reduces repeat surgery for breast cancer patients

AuntMinnie.com Headlines — Mon, 30 Jan 2012 07:00:00 +0100

The use of preoperative MRI in women with newly diagnosed breast cancer enables (more) (Source: AuntMinnie.com Headlines)

4-week vaccination regimen knocks out early breast cancer tumors, Penn researchers report

EurekAlert! - Medicine and Health — Mon, 30 Jan 2012 05:00:00 +0100

(University of Pennsylvania School of Medicine) Researchers at the Perelman School of Medicine at the University of Pennsylvania report that a short course of vaccination with an anti-HER2 dendritic cell vaccine made partly from the patient's own cells triggers a complete tumor eradication in nearly 20 percent of women with ductal carcinoma in situ, an early breast cancer. (Source: EurekAlert! - Medicine and Health)

Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells

Molecular Carcinogenesis — Mon, 30 Jan 2012 05:00:00 +0100

AbstractBreast cancer patients with HER‐2 positive or estrogen receptor negative tumors have a poor prognosis because these tumors are aggressive and respond poorly to standard therapies. Histone deacetylase (HDAC) inhibitors have been shown to decreased cell survival, which suggests that HDAC inhibitors may be developed for preventing and treating breast cancer. Curcumin has anti‐inflammatory and proapoptotic effects in cancer cells. We determined whether the HDAC inhibitor, Tricostatin A (TSA) in combination with curcumin would produce greater antiproliferative and apoptotic effects than either agent alone. Increasing the concentration of curcumin from 10 to 20 µM enhanced the growth inhibitory effects of the combination in SkBr3 and 435eB breast cancer cells, which was accompanie...

Validation of the Gail model for predicting individual breast cancer risk in a prospective nationwide study of 28,104 Singapore women

Breast Cancer Research — Mon, 30 Jan 2012 05:00:00 +0100

Conclusions: The GM over-predicts the risk of invasive breast cancer in an Asian developed-country setting as demonstrated in a large prospective trial, with the largest difference seen in older women aged between 60 and 64 years old. The reason for the discrepancy is likely to be multifactorial, including a true reduction of breast cancer, as well as lower mammographic screening prevalence locally. (Source: Breast Cancer Research)

Breastfeeding and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

Conclusions We conclude that breastfeeding possibly decreases the risk of breast cancer among Japanese women. (Source: Japanese Journal of Clinical Oncology)

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miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer

Molecular Cancer — Mon, 30 Jan 2012 05:00:00 +0100

Conclusion: Loss of miR-31 expression in TNBC cell lines is attributed to hypermethylation of its promoter-associated CpG island. Together, our results provide the initial evidence for a mechanism by which miR-31, an important determinant of the invasion metastasis cascade, is regulated in breast cancer. (Source: Molecular Cancer)

Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and Anthocianin (Ixor(R))

Radiation Oncology — Mon, 30 Jan 2012 05:00:00 +0100

IntroductionThis is an observational study and the aim is to evaluate the effect of dietary supplements based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor(R)) in reducing skin toxicity due to external beam radiotherapy in patients affected by breast cancer. Materials and Methods: 71 patients were enrolled and they were divided in two different groups: a control group (CG) of 41 patients treated with prophylactic topical therapy based on hyaluronic acid and topical steroid therapy in case of occurrence of radiodermatitis, and a Ixor-Group (IG) of 30 patients treated also with an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor(R)) at a dose of 2 tablets/day, starting from 10 days before the radiation treatment until 10 days after the end of treatmen...

Experts recommend genetic counseling for young sarcoma patients

Thrive, Children's Hospital Boston — Sun, 29 Jan 2012 13:41:39 +0100

Genetic testing may help sarcoma patients and their famlies know their risk of other cancers later in life If your child is diagnosed with a sarcoma—a tumor in connective tissue like muscles or bones—it’s natural to become totally focused on his immediate recovery. But what if beating sarcoma wasn’t the only time your child might face cancer? Data shows that there is a link between sarcomas and Li-Fraumeni syndrome, a rare condition that raises a person’s risk of developing one or more cancers to as high as 85 percent. Cancers typically diagnosed in patients with Li-Fraumeni syndrome include breast cancer, sarcomas, brain tumors, acute leukemia and adrenal cortical carcinoma. Recently, the list has been expanded to include colon cancer and stomach cancer. Li-Fraumeni syndrome m...

Collaborative efforts needed to reduce cancer burden in Africa

MedWire News - Breast Cancer — Sun, 29 Jan 2012 13:23:43 +0100

Collaborative efforts among private and government health agencies, and the health industries are required to reduce the growing burden of cancer in Africa, say researchers. (Source: MedWire News - Breast Cancer)

Discovery Of Rotational Motion Of Cells That Plays A Critical Role In Their Normal Development Has Major Implications For Breast Cancer Research

Health News from Medical News Today — Sun, 29 Jan 2012 08:00:00 +0100

In a study that holds major implications for breast cancer research as well as basic cell biology, scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini. This rotation, which the researchers call "CAMo," for coherent angular motion, is necessary for the cells to form spheres... (Source: Health News from Medical News Today)

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Protect against breast cancer risk factors with flax seeds

NaturalNews.com — Sun, 29 Jan 2012 06:00:00 +0100

In the United States 1 in 8 women will be diagnosed with invasive breast cancer during her lifetime, and 1 in 3 of them will die from the disease. In 2011, there were 2.6 million breast cancer survivors coping with this diagnosis which is both personally devastating... (Source: NaturalNews.com)

how do pink ribbon donations

About.com Breast Cancer — Sun, 29 Jan 2012 05:00:00 +0100

Shop for the Cure - will it really help if you buy items adorned with pink ribbons? Where does all the money go - and how is it divided up among research, education, and sheer profit for corporations? Learn more about pink ribbons and charitable donations. (Source: About.com Breast Cancer)

HLA Alleles in Breast Cancer.

Pathology Oncology Research — Sun, 29 Jan 2012 05:00:00 +0100

Authors: Ozturk OG PMID: 22286960 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)

The Quality of Life of Young Women with Nonmetastatic Breast Cancer and their Partners’: Specific Needs Require Development of Specific Questionnaires for Each of them

The Breast Journal — Sun, 29 Jan 2012 05:00:00 +0100

(Source: The Breast Journal)

Goal adjustment, physical and sedentary activity, and well‐being and health among breast cancer survivors

Psycho-Oncology — Sun, 29 Jan 2012 05:00:00 +0100

ConclusionsGoal adjustment capacities can exert beneficial effects on breast cancer survivors' well‐being and physical health by facilitating adaptive levels of physical and sedentary activity. Integrating goal adjustment processes into clinical practice may be warranted. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

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Anti-Cancer Activities of Tea Epigallocatechin-3-Gallate in Breast Cancer Patients under Radiotherapy.

Current Molecular Medicine — Sun, 29 Jan 2012 03:18:43 +0100

Authors: Zhang G, Wang Y, Zhang Y, Wan X, Li J, Liu K, Wang F, Liu Q, Yang C, Yu P, Huang Y, Wang S, Jiang P, Qu Z, Luan J, Duan H, Zhang L, Hou A, Jin S, Hsieh TC, Wu E Abstract The purpose of this study was to test the hypothesis that administration of epigallocatechin-3-gallate (EGCG), a polyphenol present in abundance in widely consumed tea, inhibits cell proliferation, invasion, and angiogenesis in breast cancer patients. EGCG in 400 mg capsules was orally administered three times daily to breast cancer patients undergoing treatment with radiotherapy. Parameters related to cell proliferation, invasion, and angiogenesis were analyzed while blood samples were collected at different time points to determine efficacy of the EGCG treatment. Compared to patients who received radioth...

Too Few Americans Getting Screened for Common Cancers: CDC

Cancercompass News: Breast Cancer — Sun, 29 Jan 2012 00:00:00 +0100

National targets for breast, cervical and colon malignancies still not being met (Source: Cancercompass News: Breast Cancer)

Drug 'increases risk' of carpel tunnel syndrome for cancer patients

Nursing Times Breaking News — Sun, 29 Jan 2012 00:00:00 +0100

Risk of carpal tunnel syndrome is higher in breast cancer patients given the drug exemestane than in those treated with tamoxifen, according to an international study in the Lancet Oncology. (Source: Nursing Times Breaking News)

Predicting compliance and survival in palliative whole-brain radiotherapy for brain metastases

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:15 +0100

Conclusions Results suggest that the geriatric tools analysed could offer information on brain palliative radiotherapy complementary to that offered by the more usual tools. It will be interesting to study if our data could be extrapolated to the general palliative oncological field. Content Type Journal ArticleCategory Research ArticlesPages 43-49DOI 10.1007/s12094-012-0760-zAuthors Sebastià Sabater, Department of Radiation Oncology, Complejo Hospitalario Universitario, C/Hermanos Falcó, 37, ES-02006 Albacete, SpainEncarna Mur, Department of Radiation Oncology, Sant Joan University Hospital, Reus, Tarragona, SpainKatrin Müller, Department of Radiation Oncology, Sant Joan University Hospital, Reus, Tarragona, SpainMeritxell Arenas, Department of Radiation Oncolog...

Proteomic research progress in lymphatic metastases of cancers

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:11 +0100

Abstract Lymph node metastasis (LNM) is recognised as an important factor involved in malignant tumour progression by interfering with a favourable prognosis. It is involved in a variety of cancers. Proteins are believed to play important roles in the LNM of cancers. The rapid achievements of state-of-the-art proteomic techniques have emerged as the key technologies successfully applied to identify markers for cancers at high-throughput level by providing novel targets and creating possible therapeutic interventions in cancer research. This review summarises recent progress in proteomic research in hepatocarcinoma, gastric cancer, oesophageal cancer, colorectal cancer, breast cancer, lung cancer and nasopharyngeal cancer. Actin, heat-shock proteins (HSPs), annexins, cytoke...

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Upper limb progressive resistance training and stretching exercises following surgery for early breast cancer: a randomized controlled trial

Breast Cancer Research and Treatment — Sat, 28 Jan 2012 16:51:29 +0100

In conclusion, a supervised exercise program provided some, albeit small, additional benefit at 6 months post-intervention to women who had been provided with written information and reminders to use their arm. Both the groups reported few impairments including swelling immediately following the intervention and 6 months post-intervention. Notably, resistance training in the post-operative period did not precipitate lymphedema. Content Type Journal ArticleCategory Clinical TrialPages 1-10DOI 10.1007/s10549-012-1964-1Authors Sharon L. Kilbreath, Faculty of Health Sciences, University of Sydney, P.O. Box 170, Lidcombe, Sydney, NSW 1825, AustraliaKathryn M. Refshauge, Faculty of Health Sciences, University of Sydney, P.O. Box 170, Lidcombe, Sydney, NSW 1825, AustraliaJane ...

US Cancer Screening Below National Targets

Health News from Medical News Today — Sat, 28 Jan 2012 11:00:00 +0100

The percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups, according to a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) released on Friday. The report shows that in 2010, the screening rate for breast cancer was 72.4%, compared to the 2020 national target of 81%, for cervical cancer it was 83%, compared to a target of 93%, and for colorectal it was 58.6% percent, compared to a target of 70.5%... (Source: Health News from Medical News Today)

Prostate cancer's 'forgotten 10,000'

Telegraph Health — Sat, 28 Jan 2012 07:00:04 +0100

Thousands of men with prostate cancer are being "forgotten" because it is still regarded as an "old man's disease", MPs are to be warned. (Source: Telegraph Health)

Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes

Breast Cancer Research and Treatment — Sat, 28 Jan 2012 06:42:12 +0100

Abstract In order to investigate the implications of cyclooxygenase-2 (COX-2) expression in combination with Ki-67 on breast cancer outcomes, the COX-2 and Ki-67 expression levels and other clinicopathologic parameters were investigated in 861 breast cancers. Clinicopathological parameters and survival were investigated in association with the expression levels of both COX-2 and Ki-67 using univariate and multivariate analyses. COX-2 expression was positive in 493 (57.3%) of invasive tumors. COX-2 was associated with favorable markers, but was not related to survival outcome by itself. However, COX-2 in proliferative tumors [COX-2(+)/Ki-67(+)] were significantly associated with unfavorable factors and the worst survival, but COX-2 in non-proliferative tumors [COX-2(+)/Ki-6...

Ann Romney and Breast Cancer

About.com Eating Disorders — Sat, 28 Jan 2012 05:00:00 +0100

Ann Romney was diagnosed with breast cancer in 2008. Learn more about her battle with the disease and how she was diagnosed. (Source: About.com Eating Disorders)

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Cancer Screening Rates Low Among Ethnic Groups, USA

Health News from Medical News Today — Fri, 27 Jan 2012 18:00:00 +0100

Not only are relatively few Americans screened for cancer, but there are considerable disparities between ethnic and racial groups in the country, says a new report issued by NCI (National Cancer Institute) and the CDCF (Centers for Disease Control and Prevention). The authors added that screening rates are especially low among Hispanic and Asian Americans. The report is called "Cancer Screening in the United States - 2010." The Healthy People 2020 target of 81% screening rate for breast cancer was not met in 2010, which reached 72.4%... (Source: Health News from Medical News Today)

Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study

Breast Cancer Research and Treatment — Fri, 27 Jan 2012 17:55:30 +0100

Abstract NEWEST (Neoadjuvant Endocrine Therapy for Women with Estrogen-Sensitive Tumors) is the first study to compare biological and clinical activity of fulvestrant 500 versus 250 mg in the neoadjuvant breast cancer setting. We hypothesized that fulvestrant 500 mg may be superior to 250 mg in blocking estrogen receptor (ER) signaling and growth. A multicenter, randomized, open-label, Phase II study was performed to compare fulvestrant 500 mg (500 mg/month plus 500 mg on day 14 of month 1) versus fulvestrant 250 mg/month for 16 weeks prior to surgery in postmenopausal women with ER+ locally advanced breast cancer. Core biopsies at baseline, week 4, and surgery were assessed for biomarker changes. Primary endpoint: change in Ki67 labe...

Adherence and discontinuation of adjuvant hormonal therapy in breast cancer patients: a population-based study

Breast Cancer Research and Treatment — Fri, 27 Jan 2012 17:55:29 +0100

Abstract Adherence to long-term pharmacological treatment for chronic conditions is often less than optimal. Till date, a limited number of population-based studies have assessed adherence to adjuvant hormonal therapy in breast cancer, a therapy with proven benefits in terms of reductions of recurrence and mortality. We aimed to examine rates of adherence and early discontinuation in Sweden where prescribed medications are subsidized for all residents and made available at reduced out-of-pocket costs. Individual-level data were obtained from Regional Clinical Quality Breast Cancer Registers, the Swedish Prescribed Drug Register, and several other population-based registers. Multivariate logistic regression was used to analyze factors associated with adherence to prescribed...

Body size and the risk of postmenopausal breast cancer subtypes in the California Teachers Study cohort

Cancer Causes and Control — Fri, 27 Jan 2012 17:55:04 +0100

Conclusions The effects of body size on postmenopausal breast cancer risk differed by hormone receptor subtype, and among women with ER+PR+ tumors, by HT use and early adult body size. Content Type Journal ArticleCategory Original paperPages 1-13DOI 10.1007/s10552-012-9897-xAuthors Alison J. Canchola, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USAHoda Anton-Culver, Department of Epidemiology, School of Medicine, University of California, Irvine, CA, USALeslie Bernstein, Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USAChristina A. Clarke, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USAKatherine Hend...

Consensus Guidelines: Neoadjuvant Therapy in Breast CancerConsensus Guidelines: Neoadjuvant Therapy in Breast Cancer

Medscape Today Headlines — Fri, 27 Jan 2012 17:20:33 +0100

Key recommendations of an international consensus on neoadjuvant systemic therapy in primary breast cancer are discussed by Dr. Lidia Schapira. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

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Axillary dissection versus no axillary dissection in women with invasive breast cancer and sentinel node metastasis.

Canadian Journal of Surgery — Fri, 27 Jan 2012 16:01:01 +0100

Authors: Latosinsky S, Berrang TS, Cutter CS, George R, Olivotto I, Julian TB, Hayashi A, Baliski C, Croshaw RL, Erb KM, Chen J PMID: 22269305 [PubMed - in process] (Source: Canadian Journal of Surgery)

Oncotype DX testing a winner for guiding breast cancer therapy

PharmacoEconomics and Outcomes News — Fri, 27 Jan 2012 15:13:30 +0100

(Source: PharmacoEconomics and Outcomes News)

An Update on Metastatic Breast Cancer

Clinical Care Options Oncology - Breast Cancer — Fri, 27 Jan 2012 14:43:38 +0100

Learning Module - In this CME-certified slideset, William J. Gradishar, MD, FACP, and Kathy D. Miller, MD, provide an analysis of key data on metastatic breast cancer presented at the 2011 Annual Meeting of the AACR-CTRC San Antonio Breast Cancer Symposium. (Source: Clinical Care Options Oncology - Breast Cancer)

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer

NMR in Biomedicine — Fri, 27 Jan 2012 08:25:29 +0100

Altered choline phospholipid metabolism is a hallmark of cancer, leading to malignant choline metabolite profiles consisting of low glycerophosphocholine (GPC) and high phosphocholine (PC) in human breast cancers. Glycerophosphocholine phosphodiesterase (GPC‐PDE) catalyzes the degradation of GPC to free choline and glycerol‐3‐phosphate. The gene(s) encoding for the GPC‐PDE(s) responsible for GPC degradation in breast cancers have not yet been identified. Here, we demonstrate for the first time that the GPC‐PDE encoded by glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) is associated with breast cancer malignancy. Two human breast cancer cell lines (n = 8 and n = 10) and primary human breast tumor samples (n = 19) were studied with combined MRS and q...

p38{beta} Regulates Iodide Transporter in Breast Cancer Cells [Gene Regulation]

Journal of Biological Chemistry — Fri, 27 Jan 2012 05:00:00 +0100

This study demonstrates differential regulation of NIS by distinct p38 isoforms in breast cancer cells and thyroid cells. Targeting isoform-selective activation of p38 may enhance NIS induction, resulting in higher efficacy of 131I concentration and treatment of breast cancer. (Source: Journal of Biological Chemistry)

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PTP{epsi} in Human Breast Cancer Cells [Molecular Bases of Disease]

Journal of Biological Chemistry — Fri, 27 Jan 2012 05:00:00 +0100

In this study, we have investigated the functional role of PTPϵ in human breast cancer cell lines. We found the up-regulation and activation of receptor PTPϵ (RPTPϵ) in MCF-7 cells and MDA-MB-231 upon PMA, FGF, and serum stimulation, which depended on EGFR and ERK1/2 activity. Diminishing the expression of PTPϵ in human breast cancer cells abolished ERK1/2 and AKT activation, and decreased the viability and anchorage-independent growth of the cells. Conversely, stable MCF-7 cell lines expressing inducible high levels of ectopic PTPϵ displayed higher activation of ERK1/2 and anchorage-independent growth. Our results demonstrate that expression of PTPϵ is up-regulated and activated in breast cancer cell lines, through EGFR, by sustained activation of the ERK1/2 pathway, generating a po...

Cancer screening - United States, 2010.

MMWR Morb Mortal Wkl... — Fri, 27 Jan 2012 05:00:00 +0100

Authors: Abstract Each year, approximately 350,000 persons are diagnosed with breast, cervical, or colorectal cancer in the United States, and nearly 100,000 die from these diseases. The U.S. Preventive Services Task Force (USPSTF) recommends screening tests for each of these cancers to reduce morbidity and mortality. Healthy People 2020 sets national objectives for use of the recommended cancer screening tests and identifies the National Health Interview Survey (NHIS) as the means to measure progress. Data from the 2010 NHIS were analyzed to assess use of the recommended tests by age, race, ethnicity, education, length of U.S. residence, and source and financing of health care to identify groups not receiving the full benefits of screening and to target specific interventions to...

Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer

BMC Cancer — Fri, 27 Jan 2012 05:00:00 +0100

Conclusions: Both ECM1 and VEGF-C were overexpressed in breast cancer tissue samples. ECM1 expression was positively correlated with estrogen responsiveness and the metastatic properties of breast cancer. We conclude, therefore, that ECM1 and VEGF-C may have a synergistic effect on lymphangiogenesis to facilitate lymphatic metastasis of breast cancer. (Source: BMC Cancer)

Breast Cancer Radiotherapy and Coronary Artery Stenosis: Location, Location, Location [EDITORIALS]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

Potential Utility of an Expression Array Signature for Predicting Anthracycline Responsiveness or Resistance [COMMENTS AND CONTROVERSIES]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

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Distribution of Coronary Artery Stenosis After Radiation for Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion An increase of stenosis in mdLAD + dD in irradiated left-sided BC and an association between high-risk RT and stenosis in hotspot areas for radiation indicate a direct link between radiation and location of coronary stenoses. (Source: Journal of Clinical Oncology)

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases [Neurooncology]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion Prognostic factors for patients with brain metastases vary by diagnosis, and for each diagnosis, a robust separation into different GPA scores was discerned, implying considerable heterogeneity in outcome, even within a single tumor type. In summary, these indices and related worksheet provide an accurate and facile diagnosis-specific tool to estimate survival, potentially select appropriate treatment, and stratify clinical trials for patients with brain metastases. (Source: Journal of Clinical Oncology)

Making Sense of Clinical Trial Data: Is Inverse Probability of Censoring Weighted Analysis the Answer to Crossover Bias? [STATISTICS IN ONCOLOGY]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Ideally, therapeutic interventions are evaluated through randomized clinical trials. These trials are commonly analyzed with an intent-to-treat (ITT) approach, whereby patients are analyzed in their assigned treatment group regardless of actual treatment received. If an interim analysis of such trials demonstrates compelling evidence of a difference in benefit, ethical considerations often dictate that the trial be unblinded and participants be provided access to the more efficacious agent. Because interim analysis may not address longer-term outcomes of interest, important clinical questions such as overall survival benefit—the ultimate test of efficacy to many—may remain unanswered. The ensuing crossover disturbs randomization and may lead to biased longer-term analysis, comp...

Tamoxifen and anastrozole as a sequencing strategy in postmenopausal patients with endocrine-responsive early breast cancer

NeLM - News — Fri, 27 Jan 2012 05:00:00 +0100

Source: JCO Area: News The authors of this paper present the 5-year outcome analysis of Austrian Breast and Colorectal Cancer Study Group 8 (ABCSG-8). The ABCSG-8 study ABCSG-8 is a prospective, multicentre randomised, open-label study comparing 5 years of tamoxifen (TAM) treatment with 2 years of TAM followed by 3 years of anastrozole (ANA). Study participants were in the low- to moderate-risk group of endocrine receptor positive, postmenopausal patients with breast cancer not receiving any other systemic therapy. Random assignment occurred immediately after surgery, and no (neo) adjuvant chemotherapy was allowed. Both groups of patients were treated with an initial 2 years of tamoxifen (TAM) and sequenced to anastrozole (ANA) versus TAM for an additional 3 years. The primary ...

Consumer Information on: M-Vu Algorithm Engine - P100005

Food and Drug Adminstration (FDA): CDRHNew — Fri, 27 Jan 2012 05:00:00 +0100

The M-Vu Algorithm Engine is a software application designed to process digitized film images of the breast. The software analyzes the images and marks suspicious areas consistent with breast cancer for review by a radiologist. The results are displayed o (Source: Food and Drug Adminstration (FDA): CDRHNew)

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M-Vu Algorithm Engine

Medical Device Approvals — Fri, 27 Jan 2012 05:00:00 +0100

The M-Vu Algorithm Engine is a software application designed to process digitized film images of the breast. The software analyzes the images and marks suspicious areas consistent with breast cancer for review by a radiologist. The results are displayed o (Approved: 1/23/2012) (Source: Medical Device Approvals)

Knowledge of Antioxidants and Breast Cancer Risk Among Women Attending Breast Cancer Risk Assessment Clinics

Health Promotion Practice — Fri, 27 Jan 2012 05:00:00 +0100

This qualitative study used semistructured interviews to examine the accuracy of knowledge concerning antioxidants and health among a convenience sample of 79 women attending a breast cancer risk assessment clinic. Despite a high level of familiarity (98%) with the word antioxidant, few participants could name more than one of these compounds and most relied on print media (41.6%) and radio/TV (22.2%) for antioxidant information. Thematic content analysis revealed participants’ beliefs that antioxidants were strongly linked to reduced breast cancer risk and improved health. They described antioxidant functions that take place before (e.g., "Prevention . . . a best defense mechanism" and "To boost strength and good health") or after (e.g., "Fights diseases, free radicals, and cancer,"...

Harms of screening mammography for breast cancer in Japanese women.

Breast Cancer — Fri, 27 Jan 2012 05:00:00 +0100

CONCLUSIONS: The results, although preliminary, indicate the possibility that the harms of screening mammography for Japanese women are less than those for American women. PMID: 22282164 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Factors Noted to Affect Breast Cancer Treatment Decisions of Women Aged 80 and Older

Journal of the American Geriatrics Society — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionThe quality of physician documentation about decision‐making in these women was high. A great amount of thoughtful and complex decision‐making involving patients, family, and physicians occurs after a woman aged 80 and older is diagnosed with breast cancer. (Source: Journal of the American Geriatrics Society)

Mammography screening using independent double reading with consensus: Is there a potential benefit for computer-aided detection?

Acta Radiologica — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionCAD may have the potential to increase cancer detection by up to 16%, and to reduce the number of interval cancers by up to 20% in SFM and FFDM screening programs using independent double reading with consensus review. The influence of true- and false-positive CAD marks on decision-making can, however, only be evaluated in a prospective clinical study. PMID: 22287148 [PubMed - as supplied by publisher] (Source: Acta Radiologica)

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Breast Cancer Tissue Bank Opens To All, UK

Health News from Medical News Today — Fri, 27 Jan 2012 00:00:00 +0100

The first national breast cancer tissue bank in the UK has opened its vaults of precious breast cancer tissue to all researchers in the UK and Ireland, providing a massive boost to breast cancer research. The bank is a unique collaboration of four leading research institutions and the NHS. Donor's breast tissue samples, blood samples, as well as data about the donor's breast cancer are all stored in this revolutionary new bank... (Source: Health News from Medical News Today)

Image Analysis of HER2 Immunohistochemical Staining: Reproducibility and Concordance With Fluorescence In Situ Hybridization of a Laboratory-Validated Scoring Technique.

American Journal of Clinical Pathology — Thu, 26 Jan 2012 22:55:27 +0100

Authors: Minot DM, Voss J, Rademacher S, Lwin T, Orsulak J, Caron B, Ketterling R, Nassar A, Chen B, Clayton A Abstract Image analysis of the HER2 immunohistochemical (IHC) stain can help determine which breast cancer patients may benefit from HER2-targeted therapy. We studied the concordance of HER2 IHC and fluorescence in situ hybridization (FISH) as well as reproducibility of surgical pathologist (SP) and cytotechnologist (CT) interpretations using manual and image analysis methodologies on 154 IHC cases. Concordances with FISH were good for IHC negative (0, 1+) cases (range, 97%-100%) and positive (3+) cases (range, 87%-100%). Image analysis had fewer equivocal (2+) results (10.4%) than CT (14.9%) and SP (16.2%) manual methods, with higher concordances to FISH (31%, 26%, and 20...

Link Between Parabens and Breast Cancer?Link Between Parabens and Breast Cancer?

Medscape Today Headlines — Thu, 26 Jan 2012 20:34:47 +0100

A new study has found traces of parabens in breast cancer tumors. Do they play a role in the development of cancer? Medscape Medical News (Source: Medscape Today Headlines)

Avastin fights early breast cancer in 2 studies: Will it be re-approved?

Health News: CBSNews.com — Thu, 26 Jan 2012 14:47:23 +0100

Avastin's approval for treating breast cancer was revoked by FDA in November, 2011 (Source: Health News: CBSNews.com)

New breast cancer treatment available in Italy

Pharmacy Europe — Thu, 26 Jan 2012 14:19:00 +0100

Halaven® (eribulin) improves survival for women with locally advanced or metastatic breast cancer (Source: Pharmacy Europe)

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Halaven® available in Italy for breast cancer

Pharmacy Europe — Thu, 26 Jan 2012 14:19:00 +0100

Treatment for locally advanced or metastatic disease available under national reimbursement (Source: Pharmacy Europe)

Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature

Vascular Health and Risk Management — Thu, 26 Jan 2012 14:07:42 +0100

Kyrgias G, Theodorou K, Zygogianni A, Tsanadis K, Zervoudis S, Tzitzikas, Koukourakis M (Source: Vascular Health and Risk Management)

Avastin may fight early breast cancers in certain women

CTV Health — Thu, 26 Jan 2012 13:15:19 +0100

Surprising results from two new studies may reopen debate about the value of Avastin for breast cancer. The drug helped make tumours disappear in certain women with early-stage disease, researchers found. (Source: CTV Health)

Malignant melanoma, breast cancer and other cancers in patients with parkinson disease

International Journal of Cancer — Thu, 26 Jan 2012 13:06:48 +0100

This study confirms a lower cancer risk among people with Parkinson disease. Increased risks for malignant melanoma, non‐melanoma skin cancer and breast cancer might be due to shared risk factors with Parkinson disease. (Source: International Journal of Cancer)

Younger Breast Cancer Patients Have More Adverse Quality of Life Issues

Cancer Network — Thu, 26 Jan 2012 13:00:01 +0100

Breast cancer survivorship continues to rise, but the long-lasting psychosocial and quality-of-life changes that occur after treatment need to be studied, as treatment outcomes can lead to negative side effects that outlast the treatment. (Source: Cancer Network)

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Breast cancer: Reprogramming ERα

Nature Reviews Cancer — Thu, 26 Jan 2012 12:49:58 +0100

Nature Reviews Cancer 12, 79 (2012). doi:10.1038/nrc3209 Author: Gemma K. Alderton This paper maps oestrogen receptor-α (ERα) binding to chromatin in frozen samples of breast tumours to identify changes in ERα-mediated gene expression, which are modulated by FOXA1 and which correlate with prognosis. (Source: Nature Reviews Cancer)

Breast Cancer Survival - Why Avastin And Sutent Don't Help

Health News from Medical News Today — Thu, 26 Jan 2012 12:00:00 +0100

Avastin and Sutent, two breast cancer drugs, do not lead to longer survival, probably because they encourage an increase in the number cancer stem cells in breast tumors, according to a study carried out on mice by researchers from the Michigan Comprehensive Cancer Center, and published in the Proceedings of the National Academy of Sciences (early edition). Even though Sutent (sunitinib) and Avastin (bevacizumab) do shrink breast cancer tumors and slow down the rate at which the cancer develops, their effects are short-lived - the cancers starts growing again and metastasizes (spreads)... (Source: Health News from Medical News Today)

Cutaneous Silicone Granuloma Mimicking Breast Cancer after Ruptured Breast Implant

Clinical and Developmental Immunology — Thu, 26 Jan 2012 11:22:23 +0100

We describe a case of cutaneous silicone granuloma in the breast exhibiting unusual growth mimicking breast cancer after a ruptured implant. (Source: Clinical and Developmental Immunology)

Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: Prophylactic antibiotics administered preoperatively reduce the risk of SSI in patients undergoing surgery for breast cancer. Further studies involving patients undergoing immediate breast reconstruction are needed as studies have identified this group as being at higher risk of infection than those who do not undergo immediate breast reconstruction. PMID: 22258962 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

UC to Host Forum on Breast Cancer Risks and Prevention

UCSF Medical Center — Thu, 26 Jan 2012 08:00:00 +0100

WHAT: The Athena Breast Health Forum will host the first of an ongoing series of live discussions between breast cancer experts, health care providers, patients and community members about critical issues and advances in breast health. (Source: UCSF Medical Center)

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Avastin May Help Fight Early Breast Cancer

MedicineNet Cancer General — Thu, 26 Jan 2012 07:00:00 +0100

Title: Avastin May Help Fight Early Breast CancerCategory: Health NewsCreated: 1/26/2012 11:00:00 AMLast Editorial Review: 1/26/2012 (Source: MedicineNet Cancer General)

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

BMC Cancer — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion: ALDH1 expression and its prognostic effect are age-dependent. Our results support the hypothesis that breast cancer biology is different in elderly patients compared to their younger counterparts and emphasizes the importance of taking into consideration age-specific interactions in breast cancer research. (Source: BMC Cancer)

psychological impact of a breast cancer diagnosis

About.com Breast Cancer — Thu, 26 Jan 2012 05:00:00 +0100

A diagnosis of breast cancer is one of the most devastating things a woman can hear. After such shocking news, it is normal to feel a range of emotions, from despair to rage. But for some patients, even once the initial confusion and grief have dissipated, a serious mental health issue may develop. Learn what your emotional symptoms may be, and when and how to get help. (Source: About.com Breast Cancer)

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telling your kids about breast

About.com Breast Cancer — Thu, 26 Jan 2012 05:00:00 +0100

Most experts advise that parents talk to their children about their breast cancer as soon as they are able to manage their own emotions. Talking to your kids about your breast cancer diagnosis is very hard. Here are some good tips for talking to your kids about breast cancer. (Source: About.com Breast Cancer)

JTCC brings leading experts to present 2011 San Antonio Breast Cancer Symposium research

EurekAlert! - Medicine and Health — Thu, 26 Jan 2012 05:00:00 +0100

(John Theurer Cancer Center) The Breast Cancer Division of the John Theurer Cancer Center at Hackensack University Medical Center, one of the nations top 50 cancer centers, will recap and explain research from the 2011 San Antonio Breast Cancer Symposium on Friday, Feb. 17 from 7 a.m.-3 p.m. during its ninth annual Northern New Jersey Breast Cancer Conference. (Source: EurekAlert! - Medicine and Health)

RCTs: Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer

NeLM - News — Thu, 26 Jan 2012 05:00:00 +0100

Source: N Engl J Med Area: News The efficacy of neoadjuvant chemotherapy, as measured by the rate of pathological complete response varies according to breast-cancer subtype. When anthracyclines, taxanes, and agents directed against HER2 (if indicated) are used, approximately 30 to 40% of all breast cancers that are HER2-positive or triple-negative are completely eradicated locally at the time of surgery. Long-term follow-up studies have shown a consistent correlation between pathological complete response and low rates of relapse and death among patients with these two subtypes of breast cancer. Two RCTs of neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer have been published in the New England Journal of Medicine (NEJM). The GeparQuinto phase...

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

Blood — Thu, 26 Jan 2012 05:00:00 +0100

Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide association studies have identified 14 independently replicated common single nucleotide polymorphisms that influence breast cancer risk. To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (com...

The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis

BioMed Central — Thu, 26 Jan 2012 05:00:00 +0100

The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. (Source: BioMed Central)

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Accuracy of Unenhanced MR Imaging in the Detection of Axillary Lymph Node Metastasis: Study of Reproducibility and Reliability [Breast Imaging]

Radiology — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion: Unenhanced MR imaging techniques showed high accuracy in the preoperative evaluation of axillary status in patients with invasive breast cancer. Results indicate reliable and reproducible assessment with DW imaging, but it is unlikely to be useful in clinical practice. © RSNA, 2011 (Source: Radiology)

The Two-County Breast Screening Trial Cannot Provide a Reliable Estimate of the Effect of Breast Cancer Screening [Letters to the Editor]

Radiology — Thu, 26 Jan 2012 05:00:00 +0100

(Source: Radiology)

The dynamic Yin-Yang interaction of CXCR4 and CXCR7 in breast cancer metastasis

Breast Cancer Research — Thu, 26 Jan 2012 05:00:00 +0100

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer

BMC Cancer — Thu, 26 Jan 2012 05:00:00 +0100

Conclusions: Collectively, this work supports that Spy1 is a unique activator of Cdk1 in breast cancer cells and may represent a valuable drug target and/or a prognostic marker for subsets of breast cancers. (Source: BMC Cancer)