MedWorm: Cancer of the Uterus

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Sarcomatosis

Annals of Surgical Oncology — Fri, 03 Feb 2012 07:21:20 +0100

Conclusions A complete cytoreduction and low PCI score appear to be important factors in considering CRS and HIPEC for patients with peritoneal sarcomatosis. Content Type Journal ArticleCategory Regional Cancer TherapiesPages 1-6DOI 10.1245/s10434-012-2240-7Authors George I. Salti, Division of Surgical Oncology, Department of Surgery, The University of Illinois at Chicago, Chicago, IL, USALuay Ailabouni, Division of Surgical Oncology, Department of Surgery, The University of Illinois at Chicago, Chicago, IL, USASamir Undevia, Division of Hematology and Oncology, The University of Chicago, Chicago, IL, USA Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

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Uterine Cancer Surgery hystere

About.com Eating Disorders — Fri, 03 Feb 2012 05:00:00 +0100

A look at what to expect after hysterectomy for all women, with emphasis on women with uterine cancer. Find out what to expect during hysterectomy recovery and learn about estrogen replacement therapy pros and cons in uterine cancer. (Source: About.com Eating Disorders)

Insulin use is not significantly predictive for prostate cancer mortality in diabetic patients: a 12‐year follow‐up study

BJU International — Thu, 02 Feb 2012 05:00:00 +0100

CONCLUSIONS• Insulin use in diabetic patients does not significantly predict the mortality from prostate cancer.• Further confirmation in other ethnicities is needed. (Source: BJU International)

Familial renal cancer as an indicator

Kidney Cancer Association — Thu, 02 Feb 2012 04:24:08 +0100

Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) is a hereditary condition which typically presents with cutaneous and uterine leiomyomata. Papillary type II renal cell carcinoma and other less common histologic subtypes of renal cancer have been reported in HLRCC.02/01/2012 (Source: Kidney Cancer Association)

State of the Fight: Cervical Cancer

Stand Up 2 Cancer — Mon, 30 Jan 2012 22:10:36 +0100

Cervical cancer is a malignant tumor that develops in the cervix - the part of the uterus that extends into the vaginal tract. Worldwide, cervical cancer is the third deadliest form of cancer among women. There are about one-half million new cases per year, and, globally, more than 50 percent of women who get cervical cancer die from it. More than 80 percent of deaths caused by cervical cancer occur in under-developed countries. read more (Source: Stand Up 2 Cancer)

Pretreatment carcinoembryonic antigen level is a risk factor for para-aortic lymph node recurrence in addition to squamous cell carcinoma antigen following definitive concurrent chemoradiotherapy for squamous cell carcinoma of the uterine cervix

Radiation Oncology — Mon, 30 Jan 2012 05:00:00 +0100

Background: To identify pretreatment carcinoembryonic antigen (CEA) levels as a risk factor for para-aortic lymph node (PALN) recurrence following concurrent chemoradiotherapy (CCRT) for cervical cancer. Methods: From March 1995 to January 2008, 188 patients with squamous cell carcinoma (SCC) of the uterine cervix were analyzed retrospectively. No patient received PALN irradiation as the initial treatment. CEA and squamous cell carcinoma antigen (SCC-Ag) were measured before and after radiotherapy. PALN recurrence was detected by computer tomography (CT) scans. We analyzed the actuarial rates of PALN recurrence by using Kaplan-Meier curves. Multivariate analyses were carried out with Cox regression models. We stratified the risk groups based on the hazard ratios (HR). Results: Both pretrea...

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Patterns of care for brachytherapy in Europe: updated results for Spain

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:15 +0100

Conclusion The three most common treatment sites (gynaecological, breast and prostate) remain unchanged from 2002, with prostate treatments showing large increase. Advanced dosimetric techniques (MRI, PET-CT and CT-dosimetry) continue to gain adherents. Some centres treat small numbers of patients, a finding that deserves more attention in terms of cost and quality of care. Although BT remains strong in Spain, it could be further strengthened by making modern dosimetric techniques and treatments more widely available. Content Type Journal ArticleCategory Research ArticlesPages 36-42DOI 10.1007/s12094-012-0759-5Authors Ferran Guedea, Department of Radiation Oncology, Catalan Institute of Oncology, Gran vía s/n, km 2,7, ES-08907 L’Hospitalet de Llobregat, Barcelo...

Fran Drescher Patient Advocate

About.com Eating Disorders — Sat, 28 Jan 2012 05:00:00 +0100

We knew and loved Fran Drescher as The Nanny on TV in the 1990s. Shortly after the show ended, she suffered her first misdiagnosis of uterine cancer. Read about her journey from getting a corrected diagnosis to Fran's work today as advocate, author, movement leader and diplomat. (Source: About.com Eating Disorders)

Fertility Drugs and Cancer

About.com Eating Disorders — Sat, 28 Jan 2012 05:00:00 +0100

Do fertility drugs cause or increase your risk of cancer? A few studies seemed to find a connection between fertility drug use and an increased risk of breast or uterine cancer, but that's only half the story. Learn what you need to know about fertility drugs and cancer risks in this article. (Source: About.com Eating Disorders)

Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance

BMC Cancer — Sat, 28 Jan 2012 05:00:00 +0100

Conclusions: We characterized a self-renewing subpopulation of CICs found among four well known human cancer-derived cell lines (HeLa, SiHa, Ca Ski and C-4 I) and found that they express characteristic markers of stem cell, EMT and radioresistance. The fact that CICs demonstrated a higher degree of resistance to radiation than differentiated cells suggests that specific detection and targeting of CICs could be highly valuable for the therapy of tumors from the uterine cervix. (Source: BMC Cancer)

Hypofractionated radiotherapy as local hemostatic agent in advanced cancer

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Conclusion : Of 25 patients, 22 (88%) responded, and there was complete cessation of bleeding. Both 15 Gray and 20 Gray dose schedule had equal efficacy. Treatment was well tolerated without any intermission. Radiotherapy is a safe and effective option in controlling tumor bleeding. (Source: Indian Journal of Palliative Care)

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Nodal Metastasis Risk in Endometrioid Endometrial Cancer.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:42:57 +0100

CONCLUSION:: Low-risk endometrioid uterine cancer criteria may be used to help guide treatment planning for reoperation in patients with incomplete surgical staging information. LEVEL OF EVIDENCE:: II. PMID: 22270280 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)

The Role of Transabdominal Sonography in Facilitating Successful Brachytherapy Outcomes in Cervical Cancer

Journal of Diagnostic Medical Sonography — Wed, 25 Jan 2012 05:00:00 +0100

This article discusses the etiology, diagnosis, and treatment of cervical cancer. This article further explains the importance of the brachytherapy technique, the role of transabdominal sonography, and how both can lead to a successful outcome for the patient. (Source: Journal of Diagnostic Medical Sonography)

Major Annoucement on Kidney Cancer Vaccine

Kidney Cancer Association — Tue, 24 Jan 2012 22:27:31 +0100

Roswell Park Launches Landmark Immunotherapy Vaccine Trial [Read More] The ability to stretch out the attack for a long-term, durable response suggests that the vaccine may be effective in preventing disease recurrence. The new NY-ESO-1 dendritic cell vaccine is expected to show great promise in patients with bladder, brain, breast, esophageal, gastrointestinal, hepatocellular, kidney, lung, melanoma, ovarian, prostate, sarcoma and uterine tumors. 01/24/2012 (Source: Kidney Cancer Association)

Expression pattern of PAX2 in hyperplastic and malignant endometrium

Archives of Gynecology and Obstetrics — Tue, 24 Jan 2012 12:26:09 +0100

Conclusions PAX2 is expressed in hyperplastic and malignant endometrium as well as proliferative and atrophic endometrium. As the neoplastic lesion progresses from a premalignant state to endometrial cancer, PAX2 expression increases. These findings suggest that PAX2 may contribute to the development of endometrial cancer. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-6DOI 10.1007/s00404-012-2236-3Authors Korhan Kahraman, Department of Obstetrics and Gynecology, Ankara University School of Medicine, 06100 Ankara, TurkeySaba Kiremitci, Department of Pathology, Ankara University School of Medicine, Ankara, TurkeySalih Taskin, Department of Obstetrics and Gynecology, Ankara University School of Medicine, 06100 Ankara, TurkeyDuygu Kankaya, Department ...

DNA repair gene variants in endometrial carcinoma

Medical Oncology — Tue, 24 Jan 2012 06:54:26 +0100

In this study, we investigated the association of the polymorphisms in the DNA repair genes, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys, with endometrium cancer risk. Two hundred and sixty-two women were included in the study. Endometrial biopsy was performed, and on the basis of diagnosis and histological examination, women were divided into two groups: a control group (n = 158) and an endometrial cancer group (n = 104). Genotypes were determined by PCR–RFLP assays in endometrial carcinoma patients and age-matched controls. In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and ...

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Survival from common and rare cancers in Germany in the early 21st century

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: German cancer survival estimates are mostly higher than the 2000–2002 pan-European estimates. Further research is needed to investigate causes responsible for differences between German and USA cancer survival rates. (Source: Annals of Oncology)

Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients

BMC Research Notes — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: A significant prognostic value of MSN and CLDN7 in predicting disease outcomes in patients with EC was not demonstrated. Nevertheless, the high percentage of EC cases with MSN and CLDN7 immunoexpression, and their association with tumor grade and subtypes, suggests that these proteins might play a role in tumorigenesis of endometrial adenocarcinomas. Future studies are needed to shed light on their mechanistic properties in EC cells. (Source: BMC Research Notes)

Primary primitive neuroectodermal tumor of the uterus: A case report with an unusual molecular pathology finding

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Komal Kathuria, Sudeep Gupta, Amita Maheshwari, Ranjan Basak, Sangeeta Desai, Kedar K DeodharJournal of Cancer Research and Therapeutics 2011 7(4):488-490 (Source: Journal of Cancer Research and Therapeutics)

Study linking HRT to breast cancer 'was wrong'

NHS News Feed — Tue, 17 Jan 2012 10:46:00 +0100

Conclusion Researchers have reanalysed the design and data from three studies that had suggested that HRT is associated with an increased risk that breast cancer would develop. They wanted to determine whether HRT caused breast cancer to develop (that the link was “causal”). The researchers looked at a pooled analysis study called the Collaborative Reanalysis, the Women’s Health Initiative randomised controlled trials and the Million Women Study, which was a large prospective cohort study including 800,000 post-menopausal women. The researchers found that these studies each failed to meet the majority of nine criteria which would be need to be met in order to say whether the studies could establish causality. These criteria included whether the women in the studies took HRT before th...

Evaluation of organ doses in brachytherapy treatment of uterus cancer using mathematical reference Indian adult phantom

Radiation Protection Dosimetry — Tue, 17 Jan 2012 05:00:00 +0100

This study also includes a comparison of the dimension of organs in the phantom model with measured values of organs in the various investigated patients. (Source: Radiation Protection Dosimetry)

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14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma [Medical Sciences]

Proceedings of the National Academy of Sciences — Tue, 17 Jan 2012 05:00:00 +0100

We report a transforming 14-3-3 oncoprotein, which we identified through conventional cytogenetics and whole-transcriptome sequencing analysis as a highly recurrent genetic mechanism in a clinically aggressive form of uterine sarcoma: high-grade endometrial stromal sarcoma (ESS). The 14-3-3 oncoprotein results from a t(10;17) genomic rearrangement, leading to fusion between 14-3-3ε (YWHAE) and either of two nearly identical FAM22 family members (FAM22A or FAM22B). Expression of YWHAE–FAM22 fusion oncoproteins was demonstrated by immunoblot in t(10;17)-bearing frozen tumor and cell line samples. YWHAE–FAM22 fusion gene knockdowns were performed with shRNAs and siRNAs targeting various FAM22A exons in an t(10;17)-bearing ESS cell line (ESS1): Fusion protein expression was inhibited, wit...

Lifetime Cancer Risks in Individuals with Germline PTEN Mutations.

Clinical Cancer Research — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: Lifetime risks for a variety of cancers, now extending to colorectal cancer, kidney cancer, and melanoma, are increased in patients with PTEN mutations. The genotype-phenotype associations here may provide new insights on PTEN structure and function. We propose a comprehensive approach to surveillance of patients with PTEN mutations. Clin Cancer Res; 18(2); 400-7. ©2012 AACR. PMID: 22252256 [PubMed - in process] (Source: Clinical Cancer Research)

Incidence of Venous Thromboembolism in Patients Undergoing Surgical Treatment for Malignancy: An Analysis of ACS NSQIP Data 2005-2008

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:02 +0100

Conclusions: The incidence of VTE is higher in patients with malignant neoplasm undergoing surgical procedures when compared to their benign counterparts. the relative risk of VTE varies by tumor type and is not uniform across patients undergoing surgical procedures. After controlling for patient characteristics known to be associated with VTE, the odds ratio of VTE remained elevated for malignancies of specific sites. Recommendations for VTE prophylaxis for patients undergoing surgical procedures should be based on the overall risk profile of the patient including an adjustment tailored to the specific type of malignancy. (Source: Journal of Surgical Research)

Lim1/LIM1 is expressed in developing and adult mouse and human endometrium

Histochemistry and Cell Biology — Mon, 09 Jan 2012 19:35:15 +0100

Abstract Lim1 encodes a homeodomain transcription factor required for head, kidney and female reproductive tract development in the murine embryo. Recently, Lim1 expression was documented in several adult murine and human organs. In the developing female reproductive tract, Lim1 expression was first detected in the Müllerian ducts. Using immunofluorescence, we detected LIM1 expression in a developmental model of human female reproductive tract which was established by recombination of neonatal uterine mesenchyme with human embryonic stem cells. In addition, we report a dynamic expression of Lim1/LIM1 in neonatal and adult mouse, and adult human endometrial epithelium and stroma as revealed by immunofluorescence and quantitative real-time polymerase chain reaction. LIM1 ex...

The discovery of placenta growth factor and its biological activity.

exp Mol Med — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Falco SD Abstract Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration (Carmeliet and Jain, 2011). Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placental growth factor (PlGF), and the related receptors VEGF receptor 1 (VEGFR-1,...

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Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort

Occupational and Environmental Medicine — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions Cadmium appears to be associated with overall cancer mortality in men and women, but the specific cancers associated differ between men and women, suggesting avenues for future research. Limitations of the study include the possibility of uncontrolled confounding by cigarette smoking or other factors, and the limited number of deaths due to some cancers. (Source: Occupational and Environmental Medicine)

Outcome of investigations for postmenopausal vaginal bleeding in women under the age of 50years.

Gynecologic Oncology — Sun, 08 Jan 2012 05:00:00 +0100

CONCLUSIONS: We found no cases of endometrial cancer amongst 260 women presenting with postmenopausal vaginal bleeding under the age of 50years. These women could be investigated on a less urgent basis depending on the available resources. PMID: 22233690 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

LINE-1 hypomethylation in familial and sporadic cancer

Journal of Molecular Medicine — Sat, 07 Jan 2012 16:55:24 +0100

Abstract Increased and decreased methylation at specific sequences (hypermethylation and hypomethylation, respectively) is characteristic of tumor DNA compared to normal DNA and promotes carcinogenesis in multiple ways including genomic instability. Long interspersed element (LINE), an abundant class of retrotransposons, provides a surrogate marker for global hypomethylation. We developed methylation-specific multiplex ligation-dependent probe amplification assays to study LINE-1 methylation in cases of colorectal, gastric, and endometrial cancer (N = 276), stratified by patient category [sporadic; Lynch syndrome (LS); familial colorectal cancer type X (FCCX)] and microsatellite instability status. Within each patient group, LINE-1 showed lower methylation in tumor DNA ...

Risk of Subsequent Primary Thyroid Cancer after Another Malignancy: Latency Trends in a Population-based Study

Annals of Surgical Oncology — Fri, 06 Jan 2012 16:43:43 +0100

Conclusions Many common cancers are associated with increased risk of SPTC beyond 12 months of initial diagnosis. Although this can be explained partly by continued surveillance bias, radiation effects, and known rare familial associations for some tumors, these factors alone are unlikely to explain the persistent, significant two-way association with renal and breast cancers. Additional research is needed to further define the biological and environmental mechanisms underlying these associations. Content Type Journal ArticleCategory Endocrine TumorsPages 1-10DOI 10.1245/s10434-011-2193-2Authors Geeta Lal, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USAMegan Groff, Department of Surgery, University of Iowa Hospitals and Clin...

MED12 mutations in uterine fibroids – their relationship to cytogenetic subgroups

International Journal of Cancer — Thu, 05 Jan 2012 05:00:00 +0100

AbstractRecurrent chromosomal alterations are found in roughly 20% of all uterine fibroids but in the majority cytogenetic changes are lacking. Recently, mutations of the gene mediator subcomplex 12 (MED12) have been detected in a majority of fibroids but no information is available whether or not they co‐occur with cytogenetic subtypes as e.g. rearrangements of the genes encoding high mobility group AT‐hook (HMGA) proteins. In a total of 80 cytogenetically characterized fibroids from 50 patients we were not only able to confirm the frequent occurrence of MED12 mutations but also to stratify two mutually exclusive pathways of leiomyomagenesis with either rearrangements of MED12 reflected by clonal chromosome abnormalities affecting 12q14∼15 or by mutations affecting exon 2 of MED12. ...

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Systemic Sclerosis and Multiple Cancers of the Female Genital Tract: Prolonged Survival following Current Treatment Strategies

Clinical and Developmental Immunology — Wed, 04 Jan 2012 14:29:49 +0100

Conclusion. Although our patient was diagnosed at advanced stage disease, prolonged survival may be related with radical surgery and postoperative adjuvant chemotherapy according to current treatment strategies. (Source: Clinical and Developmental Immunology)

Fertility sparing management of endometrial adenocarcinoma and atypical hyperplasia: a literature review.

Bulletin du Cancer — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Koskas M, Yazbeck C, Walker F, Delorme P, Azria E, Luton D, Madelenat P Abstract In endometrial carcinoma (EC) and atypical hyperplasia (AH) diagnosed in childbearing years, the principle of uterine sparing consists in prescription of antigonadotropic treatment to obtain the remission of the endometrial lesion and allow pregnancy, always with a close follow-up looking for progression or persistence of the tumour. Studies evaluating this strategy have suggested the safety of such an approach, but numerous questions remain unanswered, like those concerning the type and the duration of treatment, and the systematic use of Assisted Reproductive Technologies… We performed a critical literature review in order to analyse patients and tumoral characteristics, treatment manageme...

Endometrial Stromal Polyps in Rodents: Biology, Etiology and Relevance to Disease in Women.

Toxicologic Pathology — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Davis B Abstract Endometrial stromal polyps (ESP) are a common spontaneous reproductive tract lesion in the female rat. However, there is limited information concerning the etiology, biology, and significance of these polyps as an end point in toxicology and carcinogenicity studies. This paper reviews relevant literature to address these aspects of ESP with respect to potential relevance to human uterine tumors. Endometrial stromal polyps in rodents appear as age-related lesions. There are only a few chemicals tested for carcinogenicity in rat and mouse cancer bioassays associated with increased incidence of ESP with no common characteristics or mechanism of action. Uterine endometrial polyps that occur in women and the uterine stromal polyps that occur in rodents have dis...

Collision of three histologically distinct endometrial cancers of the uterus.

J Korean Med Sci — Sun, 01 Jan 2012 05:00:00 +0100

We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed müllerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcinoma component invaded the underlying myometrium and metastasized to the regional lymph node. Adjuvant chemotherapy and radiation therapy were performed. The patient is sti...

Evaluation and management of abnormal uterine bleeding in premenopausal women.

American Family Physician — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Sweet MG, Schmidt-Dalton TA, Weiss PM, Madsen KP Abstract Up to 14 percent of women experience irregular or excessively heavy menstrual bleeding. This abnormal uterine bleeding generally can be divided into anovulatory and ovulatory patterns. Chronic anovulation can lead to irregular bleeding, prolonged unopposed estrogen stimulation of the endometrium, and increased risk of endometrial cancer. Causes include polycystic ovary syndrome, uncontrolled diabetes mellitus, thyroid dysfunction, hyperprolactinemia, and use of antipsychotics or antiepileptics. Women 35 years or older with recurrent anovulation, women younger than 35 years with risk factors for endometrial cancer, and women with excessive bleeding unresponsive to medical therapy should undergo endometrial biopsy. Tr...

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[Effects of physical activity on cancer risk and disease progression after cancer diagnosis].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Steindorf K, Schmidt M, Ulrich C Abstract Numerous epidemiologic studies have demonstrated that regular physical activity convincingly reduces risk for colon cancer, probably for endometrium and postmenopausal breast cancer, and possibly for premenopausal breast, prostate, lung, and pancreas cancer. Relative risk reductions range from 10-30%. On the absolute scale about 9-19% of the most frequent cancers can be attributed to a lack of sufficient physical activity. Thus, exercise, as a modifiable health behavior, has a strong potential for primary cancer prevention. Current recommendations call for at least 30-60 min of moderate to vigorous activity daily. Physical activity is also increasingly gaining importance in cancer treatment and is now considered to be feasible, sa...

Genetic Disease in the Children of Danish Survivors of Childhood and Adolescent Cancer [Pediatric Oncology]

Journal of Clinical Oncology — Thu, 29 Dec 2011 05:00:00 +0100

Conclusion Mutagenic chemotherapy and radiotherapy doses to the gonads were not associated with genetic defects in children of cancer survivors. However, larger studies need to be conducted to further explore potential associations between high-dose pelvic irradiation and specific adverse pregnancy outcomes. (Source: Journal of Clinical Oncology)

Uterine Cancer

Springer Medicine titles — Wed, 28 Dec 2011 12:07:16 +0100

Screening, Diagnosis, and Treatmentseries:Current Clinical OncologyThere are an estimated 41,000 new cases of Uterine and Endometrial Cancer each year in the United States alone, resulting in roughly 7300 deaths. In Uterine Cancer: Screening, Diagnosis and Treatment, Franco Muggia, Esther Oliva and a panel of prominent medical and gynecologic oncologists survey all aspects of Uterine and Endometrial Cancer, including current screening methods, staging and ... (Source: Springer Medicine titles)

Widespread Expression of {gamma}-Glutamyl Cyclotransferase Suggests It Is Not a General Tumor Marker

Journal of Histochemistry and Cytochemistry — Wed, 28 Dec 2011 05:00:00 +0100

-Glutamyl cyclotransferase (GGCT) contributes to the -glutamyl cycle that regulates glutathione metabolism. Although GGCT has been implicated in several studies as a possible cancer marker, little is known about its distribution in cells and tissues. The authors investigated GGCT expression in normal tissues and tumors using Western blots and immunohistochemistry with a novel anti-GGCT monoclonal antibody. GGCT was detected in most organs and was mainly found in epithelial cells. Although the intracellular distribution was mainly cytoplasmic, in some situations, nuclear staining was strong. A significant increase in the expression of GGCT was found in tumors of the lung, esophagus, stomach, bile duct, and uterine cervix. In contrast, there was a significant decrease in expression in renal ...

Ovarian preservation during treatment of early stage endometrial cancer.

Bulletin du Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Poilblanc M, Samouelian V, Querleu D Abstract Endometrial cancer staging is based on surgery. No matter the age of the patient, the surgical staging includes at least a total hysterectomy with bilateral salpingo-oophorectomy. Twenty to 25% of the patients diagnosed with endometrial cancer are younger than 45 years. Although some discrepancies among series may be observed, in this population, endometrial cancers are mainly of lower grade, confined to the uterus (without ovarian involvement) and of better prognosis compared to older patients. The impact of premature menopause on the quality of life, cardiovascular and bone systems should not be neglected. This raises the issue of the systematic bilateral oophorectomy legitimacy while staging endometrial cancer staging in y...

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Generation and characterization of orthotopic murine models for endometrial cancer

Clinical and Experimental Metastasis — Sat, 24 Dec 2011 16:45:43 +0100

We describe the generation of two orthotopic murine models for endometrial cancer (EC).The first model is generated from endometrial Hec-1A cancer cells transfected with luciferase and injected directly into the uterus of female mice. This model allows a follow-up with bioluminescence imaging (BLI) along the experiment and generates abdominal dissemination and lymphatic and hematogenous metastases in high percentages, also detectables with BLI. The dissemination pattern of this model imitates the advanced stages of EC in patients, and its molecular profile corresponds to aggressive type 2 EC (p53 positive, hormone receptors negative, high percentage of Ki67 positive cells). The second model is derived from endometrioid human tissue collected from surgical pieces. By injecting this ti...

Intrauterine device embedded into the bladder wall with stone formation: laparoscopic removal is a minimally invasive alternative to open surgery

International Urogynecology Journal — Wed, 21 Dec 2011 20:08:33 +0100

Abstract Spontaneous perforation of the uterus and intravesical intrauterine device (IUD) is very rare. The treatment options for an intravesical IUD are open surgery or cystoscopic removal. Open surgery has been used generally for the removal of IUDs with formation of big stones or partial penetration of the bladder wall. In this case, we removed an IUD (multiload Cu 375®) with calculus that had sunk deeply into the bladder wall via laparoscopic partial cystectomy. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s00192-011-1632-8Authors Dong Gil Shin, Department of Urology, Medical Research Institute, Pusan National University Hospital, 1-10 Ami-Dong, Seo-gu, Pusan, 602-739 South KoreaTae Nam Kim, Department of Urology, Medical Research Institute...

Health Perk

MedlinePlus Health News — Wed, 21 Dec 2011 15:06:20 +0100

Source: HealthDay - Related MedlinePlus Pages: Antioxidants, Uterine Cancer (Source: MedlinePlus Health News)

MR-guided high-intensity focused ultrasound for noninvasive cancer treatment.

Cancer Imaging — Tue, 20 Dec 2011 19:54:02 +0100

Authors: Huisman M, van den Bosch MA Abstract Magnetic resonance (MR)-high-intensity focused ultrasound (HIFU) is an innovative, noninvasive tumour ablation technique. MR imaging and focused ultrasound are combined allowing real-time anatomic guidance and temperature mapping during treatment. Recently, the volumetric ablation approach has been introduced in order to reduce treatment length and provide more homogeneous tumour ablation. After successful treatment of uterine fibroids, MR-HIFU is currently being investigated for the treatment of malignant tumours. Palliative treatment of painful bone metastases is already applied in clinical practice. Several issues need to be further investigated for successful cancer treatment with MR-HIFU, including patient selection criteria, defin...

Hormone may ease menopause symptoms

NHS News Feed — Tue, 20 Dec 2011 18:00:00 +0100

Conclusion This small, randomised controlled trial found that both menopause symptoms and measures of sexual function could be improved by three types of hormone therapy. The study compared a form of HRT, tibolone (a unique drug with oestrogen, progestogen and male hormone activity) and another type of hormone therapy called DHEA, which is not currently licensed for use in the UK. One group of women received vitamin D but no hormone therapies. The study was small, including 48 women in total and 12 in each group. This means there is a higher likelihood the findings are due to chance. Additionally, although the women saw improvements in sexual function, they had normal sexual function at the start of the study and did not have a clinical diagnosis of sexual dysfunction. It is not known whet...

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Safe Criteria for Less Radical Trachelectomy in Patients with Early-Stage Cervical Cancer: A Multicenter Clinicopathologic Study

Annals of Surgical Oncology — Tue, 20 Dec 2011 06:42:35 +0100

Conclusions Less radical trachelectomy may be safe in patients with early-stage cervical cancer who have tumor size ≤1 cm. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1245/s10434-011-2148-7Authors Hee Seung Kim, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, KoreaChel Hun Choi, Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaMyong-Chul Lim, Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, KoreaSuk-Joon Chang, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, KoreaYong Beom Kim, Department of Obstetrics and Gynecology, Seoul National Univers...

The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Tue, 20 Dec 2011 05:00:00 +0100

Conclusions: Malignant mixed műllerian tumour is characterised by a high incidence of lymph node metastases and advanced stage at diagnosis, leading to poorer overall survival than other subtypes of endometrial carcinoma. Clinical trials for MMMT are critical for improving treatment strategies. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

[Cervical cancer screening in Hungary - epidemiological, historical and methodological aspects].

Orvosi Hetilap — Sun, 18 Dec 2011 05:00:00 +0100

Authors: Langmár Z, Németh M, Kornya L Abstract The issue of cervical cancer has been raised again recently, as opposed to other states of the European Union our country shows a high incidence and mortality rate of cervical carcinoma. Although in the 21st century not a single woman should die of cervical cancer, cervical cancer claims the lives of approximately 500 women in Hungary annually until this day. The most typical point of development is where the columnar epithelium of the cervical canal and the squamous epithelium of the uterine cervix meet, the so called transformation zone (squamocolumnar junction). The disease is a several year long process of squamous epithelium metaplasia. This is what provides the opportunity for screening, as by recognizing the lesion in a preca...

Preimplantation genetic diagnosis for inherited breast cancer: first clinical application and live birth in Spain

Familial Cancer — Sat, 17 Dec 2011 16:42:05 +0100

Abstract Carriers of a mutation in BRCA1/2 genes confront a high lifetime risk of breast and ovarian cancer and fifty percent probability of passing the mutation to their offspring. Current options for risk management influence childbearing decisions. The indications for preimplantation genetic diagnosis (PGD) have now been expanded to include predisposition for single-gene, late-onset cancer but few cases have been reported to date despite the favorable opinion among professionals and carriers. A 28-year-old BRCA1 mutation carrier (5273G>A in exon 19) with a strong maternal history of breast cancer and 2 years of infertility decided to pursue PGD to have a healthy descendent after an accurate assessment of her reproductive options. The procedure was approved by the...

Outcomes and toxicities for the treatment of stage IVB cervical cancer

Archives of Gynecology and Obstetrics — Thu, 15 Dec 2011 16:49:53 +0100

Conclusions CCRT using combination chemotherapeutic agents may not have survival advantage over single agent cisplatin-based CCRT. Further improvement in treatment is needed to increase survival outcomes and to decrease treatment-related toxicities in patients with stage IVB cervical cancer. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-9DOI 10.1007/s00404-011-2173-6Authors Jong Ha Hwang, Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 323 Illsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769 KoreaMyong Cheol Lim, Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 323 Illsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769 KoreaSang-Soo Seo, Center for Uterine Cancer, Researc...

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Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase.

Cancer Biology and Therapy — Thu, 15 Dec 2011 05:00:00 +0100

Authors: Chang MY, Smith C, Duhadaway JB, Pyle JR, Boulden J, Peralta Soler A, Muller AJ, Laury-Kleintop LD, Prendergast GC Abstract Indoleamine 2,3-dioxygenase (IDO) modifies adaptive immunity, in part, by determining the character of inflammatory responses in the tissue microenvironment. Small molecule inhibitors of IDO are being developed to treat cancer, chronic infections and other diseases, so the systemic effects of IDO disruption on inflammatory phenomena may influence the design and conduct of early phase clinical investigations of this new class of therapeutic agents. Here, we report cardiac and gastrointestinal phenotypes observed in IDO deficient mice that warrant consideration in planned assessments of the safety risks involved in clinical development of IDO inhibitors...

Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950-2003: An Overview of Cancer and Noncancer Diseases.

Radiation Research — Thu, 15 Dec 2011 05:00:00 +0100

Authors: Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ, Sakata R, Sugiyama H, Kodama K Abstract This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 LSS cohort members with DS02 dose estimates have died. The 6 years of additional follow-up since the previous report provide substantially more information at longer periods after radiation exposure (17% more cancer deaths), especially among those under age 10 at exposure (58% more deaths). Poisson regression methods were used to investigate the magnitude of the ra...

Study Finds Coffee May Lower Risk of Endometrial Cancer

MedlinePlus Health News — Tue, 13 Dec 2011 17:09:17 +0100

Source: American Cancer Society Related MedlinePlus Page: Uterine Cancer (Source: MedlinePlus Health News)

Some muscular dystrophy patients at increased risk for cancer

EurekAlert! - Medicine and Health — Tue, 13 Dec 2011 05:00:00 +0100

(University of Rochester Medical Center) People who have the most common type of adult muscular dystrophy also have a higher risk of getting cancer, according to a paper published today in the Journal of the American Medical Association. Patients with myotonic muscular dystrophy are at increased risk for cancer of the brain, ovary, colon, and the uterine lining known as the endometrium. (Source: EurekAlert! - Medicine and Health)

Cancer Risk Among Patients With Myotonic Muscular Dystrophy [Original Contribution]

JAMA — Tue, 13 Dec 2011 05:00:00 +0100

Conclusion Patients with MMD identified from the Swedish and Danish patient registries were at increased risk of cancer both overall and for selected anatomic sites. (Source: JAMA)

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Contraceptive Pills For Nuns?

Health News from Medical News Today — Mon, 12 Dec 2011 16:00:00 +0100

Compared with women who have children, Catholic nuns like any other women who do not bear children (nulliparous women) are at an increased risk of dying from ovarian, uterine, and breast cancer. According to a comment by Dr Kara Britt, Monash University, Melbourne, Australia, and Professor Roger Short, University of Melbourne, Australia, published Online First by The Lancet, the contraceptive pill should be given to Catholic nuns for health reasons as they reduce overall mortality and uterine and ovarian cancer deaths, rather than as a contraceptive measure... (Source: Health News from Medical News Today)

Thematic reviews issues published in Journal of Endocrinology

Society for Endocrinology — Mon, 12 Dec 2011 12:00:00 +0100

Journal of Endocrinology is publishing a series of thematic reviews issues commissioned around central themes. The latest of these 'Understanding the diversity of sex steroid action' edited by Matti Poutanen is now published FREE online. This issue includes: The diversity of sex steroid action: regulation of metabolism by estrogen signaling by Malin Hedengran Faulds, Chunyan Zhao, Karin Dahlman-Wright and Jan-Ake Gustafsson. The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer by Eric W-F Lam, Kunal Shah and Jan J Brosens. The diversity of sex steroid action: novel functions of hydroxysteroid (17?) dehydrogenases as revealed by genetically modified mouse models by Taija Saloniemi, Heli Jokela, Leena Strauss, P...

Should Nuns Be Given The Pill For Health Reasons?

Health News from Medical News Today — Mon, 12 Dec 2011 08:00:00 +0100

Professor Roger Short, from the University of Melbourne, and Dr Kara Britt, from Monash University, argue in a comment piece in The Lancet, that since the contraceptive pill reduces overall mortality and mortality specifically linked to ovarian and uterine cancer, nuns should be given the pill for health, rather than contraceptive, reasons. Nulliparous women - or women who do not have children - have more ovulatory menstrual cycles than women who have children, due to the absence of pregnancy and lactation. This increased number of cycles increases cancer risk... (Source: Health News from Medical News Today)

A 48-year-old African American Female Presents With Severe Uterine Bleeding

Cancer Network — Sat, 10 Dec 2011 02:00:01 +0100

A 48-year-old African American female presents with severe uterine bleeding. She states that she has been bleeding very heavily for the past two days and the flow is increasing. She is also diabetic and hypertensive. Pelvic examination revealed an enlarged irregularly shaped uterus. A large mass was noted by ultrasonography and the uterus was removed. A section of the mass is evaluated. (Source: Cancer Network)

AgNOR, p16 and human papillomavirus in low-grade squamous intra-epithelial lesions of the uterine cervix. Preliminary report.

Biotechnic and Histochemistry — Fri, 09 Dec 2011 05:00:00 +0100

Authors: Hidalgo J, Rocher A, López J, Gamboni M, Vighi S, Canessa O, Peressini S, Guerra F, di Carlo M, Palaoro L, Tatti S Abstract It has been shown that infection with high-risk human papillomaviruses (HR-HPV) is related to the development of cervical cancer. The persistence of the virus in intra-epithelial lesions of cervix uteri (SILs) is the basis for the application of HPV testing for screening and management of patients. Most infections by HR-HPVs resolve spontaneously, however, and do not progress to dysplasia or cancer. p16INK4a is a useful biomarker of cervical intra-epithelial neoplasia and could be a marker for the progression of low-grade squamous intra-epithelial lesions (LSILs) to high-grade squamous intra-epithelial lesions (HSILs), because it correlates independe...

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Give Nuns The Pill For Health Reasons ?

Health News from Medical News Today — Fri, 09 Dec 2011 02:00:00 +0100

Women who have children have lower risks of breast, ovarian, and uterine cancer compared childless (nulliparous) women, so researchers have suggested the possibility of giving them the pill to regulate their menstrual cycles and statistically improve their health, rather than for contraceptive reasons... (Source: Health News from Medical News Today)

Should nuns take birth control pills? What study says

Health News: CBSNews.com — Thu, 08 Dec 2011 20:00:12 +0100

Nearly 95,000 nuns worldwide "pay a terrible price for their chastity," because they face more risk for breast, ovarian, uterine cancers, authors said (Source: Health News: CBSNews.com)

Should nuns take the Pill to fight cancer?

NHS News Feed — Thu, 08 Dec 2011 18:00:00 +0100

Conclusion This opinion piece, which linked together different pieces of research, raises a serious issue: the increased risk of reproductive cancers among nuns and other women who do not bear children. It argued that nuns should be offered the pill because it has been shown to reduce the risk of two of these cancers and has also been shown to reduce mortality rates overall. However, the research cited by the authors as showing that the pill reduces mortality rates was an epidemiological study that cannot show any causal effect between the pill and reduced mortality. It is quite possible that women taking the pill lived longer because of other factors. Furthermore, the pill has side effects including headaches, weight changes and breast tenderness. It also carries a small increase in the r...

Catholic church should allow nuns to take contraceptive pill to reduce mortality rate, say scientists

Guardian Unlimited Science — Wed, 07 Dec 2011 18:06:52 +0100

Not having children puts nuns at a greater risk of cancer – and a loophole in the rules allows them to take the pillNuns should be given the contraceptive pill to reduce the high death rates from breast, ovarian and uterine cancer that result from their childlessness, say scientists.Not having children is a risk factor for cancer because pregnancy, as well as breastfeeding a baby, reduces the number of ovulatory cycles a woman has in her lifetime. More ovulatory cycles increases cancer risk. Women who begin their periods at an early age and hit the menopause late also have a higher risk.In the first half of the 20th century, scientists who studied nearly 32,000 Catholic nuns in the US established that their death rates from breast, ovarian and uterine cancer were higher than for other wo...

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause

British Journal of Pharmacology — Wed, 07 Dec 2011 06:57:49 +0100

The ancestral status of oestrogen receptor (ER) in the family of the steroid receptors has probably contributed to the pleiotropic actions of oestrogens, and in particular, that of 17β‐oestradiol (E2). Indeed, in addition to their well‐described role in sexual development and reproduction, they influence most of the physiological processes. The pathophysiological counterpart of these actions includes prevention of osteoporosis, atheroma and type 2 diabetes, and also the promotion of uterus and breast cancer growth. Thus, the major challenge consists in uncoupling some beneficial actions from other deleterious ones, that is, selective ER modulation. Tamoxifen and raloxifene are already used, as they prevent the recurrence of breast cancer and mimic oestrogen action mainly on bone. Both...

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Combined E7-Dendritic Cell-Based Immunotherapy and Human Sodium/Iodide Symporter Radioiodine Gene Therapy with Monitoring of Antitumor Effects by Bioluminescent Imaging in a Mouse Model of Uterine Cervical Cancer

Cancer Biotherapy and Radiopharmaceuticals — Tue, 06 Dec 2011 21:26:39 +0100

Cancer Biotherapy & Radiopharmaceuticals Dec 2011, Vol. 26, No. 6: 671-679. (Source: Cancer Biotherapy and Radiopharmaceuticals)

Whole-body MRI in neurofibromatosis: incidental findings and prevalence of scoliosis

Skeletal Radiology — Tue, 06 Dec 2011 17:04:00 +0100

Conclusions Incidental findings in the neurofibromatoses frequently involve the skeleton. Given the relatively high incidence of unsuspected osteonecrosis and stress fractures, close attention to the skeleton on WBMRI is advised. In addition, knowledge of common incidental findings can help clinicians prepare patients who undergo WBMRI for potential unexpected findings. Content Type Journal ArticleCategory Scientific ArticlePages 1-7DOI 10.1007/s00256-011-1333-xAuthors Jacob L. Jaremko, Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USAPeter J. MacMahon, Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General H...

An audit of indications and complications associated with elective hysterectomy at a public service hospital in South Africa

International Journal of Gynaecology and Obstetrics — Tue, 06 Dec 2011 05:00:00 +0100

Conclusion: Most hysterectomies were carried out abdominally rather than vaginally, in part because many patients presented with advanced cancer or other condition that warranted this approach. Because of resource constraints, patients with benign conditions were more likely to be offered surgery if they had a clearly defined condition. (Source: International Journal of Gynaecology and Obstetrics)

Do uterine risk factors or lymph node metastasis more significantly affect recurrence in patients with endometrioid adenocarcinoma?

Gynecologic Oncology — Tue, 06 Dec 2011 05:00:00 +0100

CONCLUSIONS: Patients with H-IR disease based on uterine characteristics alone have substantial risk of nodal involvement. Knowledge of LN status may better define risk, prognosis, and postoperative treatment. PMID: 22155415 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Locally advanced colorectal cancer: results of surgical treatment and prognostic factors

Arquivos de Gastroenterologia — Sun, 04 Dec 2011 09:45:50 +0100

CONCLUSIONS: Locally advanced carcinomas were found in 13.2% of patients. Survival rates were negatively affected by rectal location and adverse histological features. Number of involved organs and neoplastic adhesions did not influenced chances of survival. A radical R0 extended resection was achieved in a high proportion of cases, resulting in a 60% cancer-free survival under acceptable operative risks.OBJETIVOS: Avaliar a incidência, os resultados operatórios e os fatores prognósticos relacionados aos tumores colorretais localmente avançados. MÉTODOS: A população deste estudo foi constituída por 679 pacientes com câncer colorretal tratados entre 1997 e 2007. Dados clínicos, cirúrgicos e histológicos foram analisados. RESULTADOS: Noventa pacientes (mulheres 61%; idade media 5...

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Confirmatory factor analysis of the Sexual Adjustment and Body Image Scale in women with gynecologic cancer

Cancer — Sun, 04 Dec 2011 01:25:37 +0100

CONCLUSIONS:These results confirm the 2‐factor structure of the SABIS‐G and provide evidence that this is a valid and reliable instrument to measure changes in body image and sexuality in women after a diagnosis of GC. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.

Gynecologic Oncology — Sat, 03 Dec 2011 05:00:00 +0100

CONCLUSIONS: The increased expression of ER stress markers in endometrioid endometrial carcinomas suggests a role for ER stress, the UPR and, possibly, GRP78 in endometrial cancer. Whether this mechanisms have a substantial function in the pathogenesis of malignant transformation of human endometrium is still under investigation in our laboratory. PMID: 22146569 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Estimation of Cancer Incidence and Mortality Attributable to Overweight, Obesity, and Physical Inactivity in China.

Nutrition and Cancer — Fri, 02 Dec 2011 05:00:00 +0100

This study evaluated the proportion of cancers of colon, rectum, pancreas, breast (postmenopausal), endometrium, and kidney attributable to overweight [30 kg/m(2) > body mass index (BMI) ≥ 25 kg/m(2))/obesity (BMI ≥ 30 kg/m(2)) and physical inactivity in China in 2005. Data of prevalence of overweight/obesity and lack of physical activity were derived from cross-sectional surveys among representative samples of Chinese population, and data of relative risks on cancers were derived from meta-analyses or large-scale studies from China and East Asian populations. The attributable fractions were calculated by combining both data of prevalence and relative risks. In China in 2005, 0.32% of cancer deaths and 0.65% of cancer cases were attributable to overweight and obesity combined. Lack ...

Trends in bilateral oophorectomy at the time of hysterectomy for benign disease.

Obstetrics and Gynecology — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSION: : Age, route of hysterectomy, and concomitant gynecologic diagnoses influence oophorectomy rate. From 2001 to 2006, a significant decrease in the performance of oophorectomy at the time of benign hysterectomy was noted in women aged younger than 55 years. Recent studies of complications of hormone therapy and prophylactic oophorectomy may have influenced patients' and physicians' decision-making, leading to lower oophorectomy rates. LEVEL OF EVIDENCE: : II. PMID: 22105256 [PubMed - in process] (Source: Obstetrics and Gynecology)

A phase II study single agent of aflibercept (VEGF Trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma. A trial of the Princess Margaret Hospital, Chicago and California Cancer Phase II Consortia.

Gynecologic Oncology — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSIONS: Single agent aflibercept has modest activity in patients with uterine leiomyosarcoma and minimal activity in women with carcinosarcoma. PMID: 22138373 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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[Synchronous primary endometrial and fallopian tube cancers: one case report].

Journal of Southern Medical University — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Wang H, Xiao SS, Zeng F Abstract OBJECTIV: A patient was admitted for menopause for 2 years and abnormal vaginal bleeding and abdominal pain for 2 months. Gynecological examination revealed uterine atrophy without abnormal findings in the bilateral adnexa. CA125 and CEA levels were normal. The patient underwent laparoscopically assisted vaginal hysterectomy with bilateral salpingo-oophorectomy. Pathological examination of the surgical specimens revealed synchronous primary cancers stage Ia in both the endometrium and the right fallopian tube. The patient then received 6 cycles of chemotherapy with oxaliplatin combined with docetaxel given intravenously and remained alive without evidence of recurrence. Synchronous primary endometrial and fallopian tube cancer is a rare cli...

Comparison of diversity of torque teno virus 1 in different mucosal tissues and disorders.

Acta Microbiologica et Immunologica Hungarica — Thu, 01 Dec 2011 05:00:00 +0100

In conclusion, genotype and even subtype distribution may be important in association with diseases, therefore using this classification for characterization of intraspecies diversity of TTV1 is proposed. PMID: 22207290 [PubMed - as supplied by publisher] (Source: Acta Microbiologica et Immunologica Hungarica)

Clear Cell Cancer of the Uterine Corpus: The Association of Clinicopathologic Parameters and Treatment on Disease Progression

Clinical and Developmental Immunology — Wed, 30 Nov 2011 23:54:38 +0100

This paper presents a single-institution experience regarding the clinicopathologic features and treatment strategies used in uterine clear cell cancer (UCC), a rare, aggressive histologic subtype of uterine cancer with poor prognosis and discusses parameters associated with progression-free survival (PFS) and overall survival (OS). A retrospective chart review was performed on all patients (n=80) diagnosed with UCC and treated between 1994 and 2009 at a single academic institution. Data on demographics, FIGO stage, treatment regimens, and recurrences were collected. Patients with early-stage UCC had an excellent survival regardless of adjuvant therapy. Advanced-stage patients had a worse survival. Vaginal apex brachytherapy was associated with an increased OS (P=0.02) but not PFS (P=0.10)...

Familial renal cancer as an indicator of hereditary leiomyomatosis and renal cell cancer syndrome

Familial Cancer — Wed, 30 Nov 2011 04:39:08 +0100

We describe the case of a 31-year-old man in which the pathology review of his renal carcinoma and a positive family history of renal carcinoma allowed for the identification of a pathogenic mutation in the FH gene (c.698G>A;p.R233H) confirming the diagnosis of HLRCC. Recognition of this syndrome allowed for appropriate surveillance as well as identification of at-risk family members. Pathology review is essential for accurate diagnosis of a hereditary cancer syndrome in the setting of familial renal cancer. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10689-011-9485-3Authors Victoria M. Raymond, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-2200, USACasey M. Herron, Department of Internal Medicine, University of Mic...

Combination Hormone Therapy and Breast Tenderness Leads to Greater Risk of Breast Cancer

Cancer Network — Tue, 29 Nov 2011 12:00:00 +0100

Is estrogen plus progestin better than estrogen alone for symptom relief in menopausal women? For women who have not had a hysterectomy, adding progestin to estrogen therapy counteracts the increased risk of uterine cancer from estrogen monotherapy. However, the progestin and estrogen combination increases breast cancer risk. (Source: Cancer Network)

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Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers

American Journal of Human Biology — Mon, 28 Nov 2011 05:00:00 +0100

Conclusions:Our data expand the information on genetic variation at the PR locus in non‐western populations and support an argument for more work on the genetic epidemiology of cancer among nonwestern populations. Am. J. Hum. Biol. 2011. © 2011 Wiley Periodicals, Inc. (Source: American Journal of Human Biology)

Quality of life, lifestyle behavior and employment experience: A comparison between young and midlife survivors of gynecology early stage cancers.

Gynecologic Oncology — Wed, 23 Nov 2011 05:00:00 +0100

CONCLUSIONS: To enhance quality of life and to promote healthy lifestyle behavior of female cancer patients, particularly in younger age, it is essential to assure multidisciplinary approaches with specific medical intervention and psychosocial supports. Indeed, midlife adults seem to have a more rapid adaptive tendency to return towards levels of well-being, following cancer diagnosis and treatment, than younger patients. PMID: 22119994 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Patient reported late effects of gynecological cancer treatment.

Gynecologic Oncology — Wed, 23 Nov 2011 05:00:00 +0100

CONCLUSION: Women with gynecological cancers experience a plethora of late effects; however, very few of them have access to a survivorship plan to cope with these issues. Patient reported side effects, especially sexual dysfunction, occur more commonly than previously reported. Patient-focused tools to evaluate these side effects and access to survivorship plans are needed for comprehensive care of gynecologic cancer survivors. PMID: 22119992 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Laparoscopically guided minilaparotomy: a minimally invasive approach for the treatment of gynaecologic diseases in morbidly obese patients

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Wed, 23 Nov 2011 05:00:00 +0100

Abstract: Objective: Obese patients are at greater risk of gynaecologic surgery. Laparotomy is generally performed, even though this approach is regarded as highly invasive, whereas laparoscopy, though minimally invasive, is relatively contraindicated because of the high conversion rates to laparotomy. In light of this, we propose laparoscopically guided transverse minilaparotomy (LGTM) as a minimally invasive alternative technique. The rationale of diagnostic laparoscopy is to evaluate the feasibility of a minimally invasive approach. We have evaluated the feasibility and compared the outcomes with a historical group treated with laparotomy (LPTM), in morbidly obese patients (MOP) subjected to gynaecologic surgery.Study design: From November 2004, MOPs with body mass index (BMI) ≥40kg/m...

Study Links Coffee to Lower Risk of Endometrial Cancer

MedlinePlus Health News — Tue, 22 Nov 2011 19:00:00 +0100

Women who drank at least 4 cups a day had lower disease rates, but cause-and-effect unproven Source: HealthDay Related MedlinePlus Pages: Antioxidants, Uterine Cancer (Source: MedlinePlus Health News)

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Coffee drinkers show lower uterine cancer risk

Reuters: Health — Tue, 22 Nov 2011 18:41:34 +0100

NEW YORK (Reuters Health) - Women who down four or more cups of coffee a day may have a reduced risk of developing cancer in the lining of their uterus, researchers reported Tuesday. (Source: Reuters: Health)

Breast Tenderness With Combo Hormone Therapy May Signal Breast Cancer

Health News from Medical News Today — Tue, 22 Nov 2011 08:00:00 +0100

The debate about using menopausal hormone therapies to relieve symptoms in post-menopausal women has been ongoing. Is the combination therapy of estrogen and progestin better or worse than just giving women estrogen alone? In women who still have a uterus (those who have not had a hysterectomy), progestin counteracts the increased risk of uterus cancer when estrogen is given alone, but at the expense of an increase in breast cancer risk compared to estrogen alone... (Source: Health News from Medical News Today)

Expression of Endoglin in Primary Endometrial Cancer.

Oncology — Tue, 22 Nov 2011 05:00:00 +0100

Conclusions: An increase in endoglin protein expression level may interfere with the oncogenic potential of TGF-β(1) and TGF-β type II receptor in endometrial cancer. Correlation of the endoglin level with pronounced cancer malignancy suggests that it may be regarded as a potential prognostic marker of primary endometrial cancer. PMID: 22116456 [PubMed - as supplied by publisher] (Source: Oncology)

Endometrial Stromal Sarcoma: analysis of recurrence following adjuvant treatment.

Gynecologic Oncology — Tue, 22 Nov 2011 05:00:00 +0100

CONCLUSIONS: ESS is a rare cancer that is difficult to study. We found removal of the adnexa and post-operative treatment with progestin therapy decreased recurrence rates. These two treatment strategies should be considered in the treatment of patients with all stages of ESS. PMID: 22119993 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Summaries: International Kidney Cancer Symposium

Kidney Cancer Association — Sun, 20 Nov 2011 21:48:07 +0100

Conclusion: there is no increased risk of doing the lymph node dissection early on. Dr. Eggener-CON Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients. A Mayo study revealed no data showing therapeutic benefit in high risk patients. For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nodes. A tumor > 10 cm with sarcomatoid features and tumor necrosis is also associated with positive nodes. Looking at several studies, t...

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Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil.

Sao Paulo Medical Journal — Sun, 20 Nov 2011 21:06:02 +0100

CONCLUSION: FZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium. PMID: 22069131 [PubMed - in process] (Source: Sao Paulo Medical Journal)

Vascular endothelial growth factor (VEGF) - part 2: in endocrinology and oncology.

Endokrynologia Polska — Sun, 20 Nov 2011 03:42:05 +0100

Authors: Kajdaniuk D, Marek B, Foltyn W, Kos-Kudła B Abstract Endocrine glands are well vascularised and the structure of their vessels facilitates the exchange of various substances, including hormones. These glands are a frequent experimental model in research on VEGF and angiogenesis. VEGF participates in the pathogenesis of diabetes. Diabetic nephropathy is in essence a microvascular disease that develops as a result of a confluence of haemodynamic and metabolic perturbations. Diabetic retinopathy is the commonest microvascular complication of diabetes mellitus and is the leading cause of blindness. In diabetic retinopathy, ischaemic states, and hence tissue hypoxia and angiogenesis, take place. The participation of angiogenesis and VEGF in the pathogenesis of neoplastic disea...

Breast tenderness during combination hormone therapy linked to higher cancer risk

UCLA Newsroom: Health Sciences — Fri, 18 Nov 2011 23:13:19 +0100

This study showed that developing new breast tenderness after the start of hormone therapy was associated with increased breast cancer risk only in women on the combination estrogen-plus-progestin therapy, not estrogen therapy alone," said the study's first author, Dr. Carolyn Crandall, a UCLA professor of general internal medicine and a scientist with the Jonsson Cancer Center. The study appears in the Nov. 17 early online edition of the peer-reviewed journal Breast Cancer Research and Treatment. A previous study by Crandall, published last month, found that breast tenderness was much more pronounced after the initiation of estrogen-and-progestin therapy than after estrogen therapy alone. The association between this new-onset tenderness and changes in breast density also wa...

"Because of their praiseworthy modesty, they consult too late": regime of hope and cancer of the womb, 1800-1910.

Bulletin of the History of Medicine — Fri, 18 Nov 2011 20:00:06 +0100

"Because of their praiseworthy modesty, they consult too late": regime of hope and cancer of the womb, 1800-1910. Bull Hist Med. 2011;85(3):356-83 Authors: Löwy I Abstract Summary:The birth of the "do not delay" principle in cancer treatment has often been linked with developments in late nineteenth century: the rise of histology and cellular theory of malignancy that favored the definition of cancer as a local pathology, then the development of radical surgical techniques that transformed malignant tumors into a potentially curable condition. This text seeks to nuance this view. It points out important continuities in the understanding of the natural history of uterine cancers. At its center, the wish, already present in early nineteenth century, is to det...

Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix

International Journal of Cancer — Fri, 18 Nov 2011 05:00:00 +0100

AbstractHuman leukocyte antigen (HLA)‐G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA‐G polymorphism on risk of high‐grade cervical intraepithelial neoplasia (HG‐CIN) and cervical cancer in a Canadian population. We analyzed 1372 women from participants recruited between 2001 and 2009 in the ongoing Biomarkers of Cervical Cancer Risk (BCCR) case‐control study. A total of 539 women with histologically‐confirmed HG‐CIN and invasive cancer formed the case series, and 833 women with normal cytology served as controls. Cervical specimens were tested for human papillomavirus (HPV) DNA using the MY09/11 PCR protocol and HLA‐G allele...

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Genes involved in the immediate early response and epithelial‐mesenchymal transition are regulated by adipocytokines in the female reproductive tract

Molecular Reproduction and Development — Fri, 18 Nov 2011 05:00:00 +0100

AbstractObesity increases the risk of female reproductive tract cancers, but the underlying mechanistic link between the two is ill‐defined. Thus, the objective of the current study was to identify obesity‐dependent changes in the expression of immediate early (IE) genes that contribute to cell proliferation and differentiation, and epithelial‐mesenchymal transition (EMT) genes that promote cell migration. When HeLa cells were treated for 0‐48 hrs with IGF‐1, leptin, TNFα, or IL‐6, each individual adipocytokine altered the abundance of IE (cJUN, cFOS, and cMYC) and EMT (SNAI1, SNAI2, and TWIST1) mRNA abundance. For example, IGF‐1 increased cJUN and cFOS and decreased cMYC; leptin increased cFOS; IL‐6 increased cFOS and cMYC; and TNFα increased cJUN and cFOS mRNA abundan...

A prospective blinded comparison of the accuracy of transvaginal sonography and frozen section in the assessment of myometrial invasion in endometrial cancer.

Gynecologic Oncology — Fri, 18 Nov 2011 05:00:00 +0100

CONCLUSION: Intraoperative FS performed better than preoperative TVS in the assessment of myometrial invasion by endometrial cancer. Despite being time-consuming, FS can be regarded as a useful modality in order to decide whether to perform lymphadenectomy in cases with poor visualization of the endometrium at TVS and when TVS gives inconclusive results. PMID: 22108256 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Recognition of parametrial invasion, an important landmark when treating cervical cancer.

Gynecologic Oncology — Fri, 18 Nov 2011 05:00:00 +0100

CONCLUSION: Clear histological criteria together with the use of Masson trichrome stains to distinguish smooth muscle from fibrous tissue improved concordance rates in identifying parametrial invasion by tumor to near 100% PMID: 22108255 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Genes involved in the immediate early response and epithelial–mesenchymal transition are regulated by adipocytokines in the female reproductive tract

Molecular Reproduction and Development — Fri, 18 Nov 2011 05:00:00 +0100

AbstractObesity increases the risk of female reproductive tract cancers, but the underlying mechanistic link between the two is ill‐defined. Thus, the objective of the current study was to identify obesity‐dependent changes in the expression of immediate early (IE) genes that contribute to cell proliferation and differentiation, and epithelial–mesenchymal transition (EMT) genes that promote cell migration. When HeLa cells were treated for 0–48 hr with IGF‐1, leptin, TNFα, or IL‐6, each individual adipocytokine altered the abundance of IE (cJUN, cFOS, and cMYC) and EMT (SNAI1, SNAI2, and TWIST1) mRNA abundance. For example, IGF‐1 increased cJUN and cFOS and decreased cMYC; leptin increased cFOS; IL‐6 increased cFOS and cMYC; and TNFα increased cJUN and cFOS mRNA abundanc...

Combined E7-Dendritic Cell-Based Immunotherapy and Human Sodium/Iodide Symporter Radioiodine Gene Therapy with Monitoring of Antitumor Effects by Bioluminescent Imaging in a Mouse Model of Uterine Cervical Cancer

Cancer Biotherapy and Radiopharmaceuticals — Fri, 18 Nov 2011 04:05:46 +0100

Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. (Source: Cancer Biotherapy and Radiopharmaceuticals)

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Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract

Journal of Clinical Pathology — Thu, 17 Nov 2011 05:00:00 +0100

Conclusions KS is a potentially useful marker for the supportive diagnosis of the primary site of metastatic carcinomas or unknown primary carcinomas, especially in the abdominal cavity. (Source: Journal of Clinical Pathology)

A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases

Journal of Clinical Pathology — Thu, 17 Nov 2011 05:00:00 +0100

Conclusion The higher proportion of positive labelling of Syn, CD56, CgA, and NSE in SCCC implicated that they are valuably applied in a differential diagnosis of the malignancy. The patients with SCCC receive one to three types of therapies, including surgery, chemotherapy and radiotherapy, and have a poor prognosis. (Source: Journal of Clinical Pathology)

Ecological study suggests oral contraceptive use associated with prostate cancer?

NeLM - News — Wed, 16 Nov 2011 05:00:00 +0100

Source: BMJ Area: News According to the results of an ecological study published in the BMJ Open, a significant association between oral contraceptive (Ocs) and prostate cancer (Pca) has been shown, and it is hypothesised, that the OC effect may be mediated through environmental oestrogen levels. Researchers evaluated the association between Pca incidence and mortality and population-based use of oral contraceptives (OCs). Data from the International Agency for Research on Cancer were used to retrieve age-standardised rates of prostate cancer in 2007, and data from the United Nations World Contraceptive Use 2007 report were used to retrieve data on contraceptive use. These analyses were performed by individual nations and by continents worldwide. According to the res...

The Role of Autophagy in Human Endometrium.

Biology of Reproduction — Wed, 16 Nov 2011 05:00:00 +0100

In conclusion, these results indicate that autophagy is involved in the endometrial cell cycle affecting apoptosis and is most prominent during the late secretory phase. PMID: 22088918 [PubMed - as supplied by publisher] (Source: Biology of Reproduction)

Hereditary leiomyomatosis and renal cell cancer presenting as metastatic kidney cancer at 18 years of age: implications for surveillance

Familial Cancer — Tue, 15 Nov 2011 16:48:45 +0100

We describe the patient and family data, evaluate current evidence on renal cancer risk and surveillance in HLRCC and consider the advantages and disadvantages of starting surveillance for renal cancer in childhood. We also discuss the targeted therapies administered to our patient. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10689-011-9491-5Authors Karin Y. van Spaendonck-Zwarts, Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The NetherlandsSadhanna Badeloe, Department of Dermatology, Haaglanden Hospital, The Hague, The NetherlandsSjoukje F. Oosting, Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, The NetherlandsSjoerd Hovenga, Department of In...

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Cancer of the body of the uterus: trends in mortality and incidence in England, 1985–2008

BJOG: An International Journal of Obstetrics and Gynaecology — Tue, 15 Nov 2011 05:00:00 +0100

Conclusions After many years of declining rates, uterine cancer has become more common in the first decade of this century. One possible contributor to this increase may be an association with the increase in body mass index in women, but other causes are possible and are discussed. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

Cancer of the body of the uterus: trends in mortality and incidence in England, 1985-2008.

BJOG : An International Journal of Obstetrics and Gynaecology — Tue, 15 Nov 2011 05:00:00 +0100

Conclusions After many years of declining rates, uterine cancer has become more common in the first decade of this century. One possible contributor to this increase may be an association with the increase in body mass index in women, but other causes are possible and are discussed. PMID: 22082282 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women

Infectious Agents and Cancer — Mon, 14 Nov 2011 05:00:00 +0100

Conclusions: In women with no evidence of cytological abnormalities, the most prevalent genotypes were HPV58 with HPV16, 35, 52, 66 and 73 occurring equally. Although numerical constraints limit inference, findings that 91% of ICC harbor only a small number of HPV genotypes suggests that prevention efforts including vaccine development or adjuvant screening should focus on these genotypes. (Source: Infectious Agents and Cancer)

Papillomavirus E5: the smallest oncoprotein with many functions

Molecular Cancer — Fri, 11 Nov 2011 05:00:00 +0100

Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the etiopathogenesis of other cancer types. The early oncoproteins of PVs: E5, E6 and E7 are known to contribute to tumour progression.While the oncogenic activities of E6 and E7 are well characterised, the role of E5 is still rather nebulous. The widespread causal association of PVs with cancer makes their study worthwhile not only in humans but also in animal model systems. The Bovine PV (BPV) system has been the most useful animal model in understanding the oncogenic potential of PVs due to the pivotal role of its E5 oncoprotein in cell transformation....

Expression profiles of carcinosarcoma of the uterine corpus—are these similar to carcinoma or sarcoma?

Genes, Chromosomes and Cancer — Thu, 10 Nov 2011 05:00:00 +0100

In this study, we compared the gene expression profiles of CS, EC, and uterine sarcoma (US) and evaluated the role of EMT and chromosomal aberrations in CS tumor formation. Frozen tissues of 46 patients (14 CS, 24 EC, and 8 US) were included. The similarity was examined by Gene Set Enrichment Analysis (GSEA), Fisher's exact test, and clustering using “intrinsic gene set”. We examined the expression of 39 EMT‐related genes and evaluated TGF‐beta signaling by phospho‐SMAD2/3 (p‐SMAD2/3) staining. Chromosomal regions differing between CS and EC were identified by chromosomal GSEA and comparative genomic hybridization (CGH) microarrays. Three statistical methods confirmed that CS resembled US rather than EC. Acquired markers of EMT were upregulated and attenuated markers of EMT wer...

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Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody

Journal of Experimental and Clinical Cancer Research — Thu, 10 Nov 2011 05:00:00 +0100

Background: We evaluated the expression of human trophoblastic cell-surface marker (Trop-2) and the potential of hRS7 - a humanized monoclonal anti-Trop-2 antibody - as a therapeutic strategy against treatment-refractory human uterine (UMMT) and ovarian (OMMT) carcinosarcoma cell lines.Materials and MethodsTrop-2 expression was evaluated by immunohistochemistry (IHC) in paraffin-embedded tumor tissues, by real-time polymerase-chain-reaction (RT-PCR) and flow-cytometry in cell lines. Sensitivity to hRS7 antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity was tested using 5-hour chromium-release assays against UMMT and OMMT cells. Results: Trop-2 expression was elevated in 9 of 26 (35%) UMMT and 8 of 14 (57%) OMMT tissues tested by IHC. Positivity for Trop-2...

Cancer-Associated Nummular Loss of RPE: Expanding the Clinical Spectrum of Bilateral Diffuse Uveal Melanocytic Proliferation.

Wed, 09 Nov 2011 15:45:20 +0100

This report describes a case of cancer-associated nummular retinal pigment epithelium loss associated with uterine cancer. The patient had progressive visual loss despite treatment with plasmapheresis, intravenous immunoglobulin, and local injection of corticosteroids. Clinical deterioration was corroborated by extension of the areas of retinal pigment epithelium loss, progression of cataracts, and growth of pigmented choroidal and iris lesions. Previously published cases of cancer-associated nummular retinal pigment epithelium loss did not describe the presence of cataracts or uveal melanocytic lesions. This case expands the clinical spectrum of bilateral diffuse uveal melanocytic proliferation. PMID: 22045614 [PubMed - in process] (Source: Ophthalmic Surgery, Lasers and Imaging : the...

Comparison of physical activity levels between cancer survivors and non-cancer participants in the 2009 BRFSS

Journal of Cancer Survivorship — Wed, 09 Nov 2011 07:04:16 +0100

Conclusions This study demonstrates higher PA levels among prostate cancer survivors and lower PA levels among middle-aged cervical and endometrial cancer survivors, compared to sex- and age group-matched general populations. Content Type Journal ArticlePages 1-9DOI 10.1007/s11764-011-0204-8Authors Soyang Kwon, Consortium to Lower Obesity in Chicago Children, Children’s Memorial Hospital, 2300 Children’s Plaza Box #157, Chicago, IL 60614, USANingqi Hou, Department of Health Studies, University of Chicago, Chicago, IL, USAMeme Wang, Division of Community Health Sciences, University of Illinois, Chicago, IL, USA Journal Journal of Cancer SurvivorshipOnline ISSN 1932-2267Print ISSN 1932-2259 (Source: Journal of Cancer Survivorship)

Intraoperative frozen section is essential for assessment of myometrial invasion but not for histologic grade confirmation in endometrial cancer: a ten-year experience

Archives of Gynecology and Obstetrics — Wed, 09 Nov 2011 07:03:49 +0100

Conclusions Evaluation of the histologic grade by EB and of the depth of myometrial invasion by intraoperative biopsy is a good option for deciding the necessity of lymphadenectomy. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-011-2135-zAuthors Ebru Ozturk, Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, TurkeyEbru Dikensoy, Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, TurkeyOzcan Balat, Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, TurkeyMete Gurol Ugur, Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, TurkeyAbdullah Aydin, Department of Pathology, Gaziantep University, Gaziantep, Turkey Journal Archives of Gyneco...

The Need for Investigations to Elucidate Causes and Effects of Abnormal Uterine Bleeding

Seminars in Reproductive Medicine — Mon, 07 Nov 2011 05:00:00 +0100

This article describes a modern perspective on the basic investigations for abnormal uterine bleeding (AUB) in low-resource settings compared with a much more detailed approach for high-resource settings, bearing in mind issues of effectiveness and cost effectiveness. AUB includes any one or more of several symptoms, and it should be evaluated for the characteristics of the woman's specific bleeding pattern, her “complaint” and the presence of other symptoms (especially pain), the impact on several aspects of body functioning and lifestyle, and the underlying cause(s), especially cancer. Ideally, the evaluation is comprehensive, considering each of the potential etiological domains defined by the International Federation of Gynecology and Obstetrics PALM-COEIN system for the classifica...

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Incidental Detection of Breast Apocrine Carcinoma via Endometrial Cytology.

The Tohoku Journal of Experimental Medicine — Fri, 04 Nov 2011 07:05:02 +0100

Authors: Shiota M, Kotani Y, Umemoto M, Tobiume T, Hoshiai H Abstract Breast apocrine carcinoma is a rare malignancy characterized histologically by a predominance of acidophilic tumor cells exhibiting apocrine metaplasia. Apocrine tumors represent only about 0.4% of all breast cancers. Many cases are diagnosed at stage I or II; thus, the prognosis is better than that for other types of breast cancer. Here we present a 57-year-old female patient with primary apocrine breast carcinoma that was incidentally discovered by endometrial cytology. The patient had undergone routine uterine cancer screening at the age of 56 with resulting positive endometrial cytology. Subsequent histological examination of an endometrial biopsy revealed suspected metastatic uterine adenocarcinoma. Further ...

'English' diet could save lives in rest of UK

NHS News Feed — Thu, 03 Nov 2011 17:25:00 +0100

Conclusion This study suggests that improving the average diet in Wales, Scotland and Northern Ireland could reduce variations in disease mortality rates across the UK. This modelling study was based on observational data, so the results should be interpreted cautiously and considered as theoretical estimates only. The study had several limitations, stemming from weaknesses in modelling as well as limitations to the underlying observational research: Models rely on theoretical scenarios, and can only estimate how diseases occur and progress in the real world. Multiple factors contribute to the development of the illnesses examined here, and diet is only one of them. Smoking, drinking alcohol, exercise habits and genetics are all risk factors for cardiovascular disease, strokes and certa...

Life‐threatening anaphylaxis to leuprorelin acetate depot: Case report and review of the literature

International Journal of Urology — Thu, 03 Nov 2011 04:00:00 +0100

We present the first case report of a Japanese man who developed anaphylaxis to leuprorelin acetate depot during the treatment of metastatic prostate cancer and recovered successfully by conservative treatment. A drug‐lymphocyte stimulation test showed that not only leuprorelin acetate itself, but also its vehicle polylactic and glycolic acids, might be responsible for the anaphylaxis to leuprorelin acetate depot. Because anaphylaxis can be lethal, the present case suggests that one should bear in mind the possibility of anaphylaxis in all patients who receive gonadotropin‐releasing hormone analog depot and monitor such patients carefully. (Source: International Journal of Urology)

Early-Life Exposures and Early Onset Uterine Leiomyomata in Black Women in the Sister Study

EHP-in-Press — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early onset fibroids in blacks were similar to those in whites. However in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early onset fibroids in blacks. The general consistency of early-life findings for blacks and whites supports a possible role of early-life factors in fibroid development. (Source: EHP-in-Press)

Clinical outcome of patients with uterine sarcomas

Journal of Cancer Research and Therapeutics — Wed, 02 Nov 2011 04:00:00 +0100

Conclusion: Although limited by small sample size and retrospective nature, ours is the only study on US being reported from India. Our results have demonstrated FIGO stage of the disease, histopathology and use of PORT to be the significant prognostic factor for survival. Use of chemotherapy in future trials is warranted. (Source: Journal of Cancer Research and Therapeutics)

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Additional rectal and sigmoid mucosal points and doses in high dose rate intracavitary brachytherapy for carcinoma cervix: A dosimetric study

Journal of Cancer Research and Therapeutics — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: Our dosimetric study suggests that sigmoid points and 0.1 cm 3 receive significantly higher doses than rectal points during ICA-HDR in carcinoma of the uterine cervix. No definite conclusion on reproducible spatial distribution on orthogonal X-rays could be achieved. To document and reduce sigmoid doses, some form of 3D image-based planning is necessary. (Source: Journal of Cancer Research and Therapeutics)

The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer

International Journal of Obesity — Tue, 01 Nov 2011 04:00:00 +0100

Authors: A Villavicencio, G Aguilar, J Acuña, F Gabler, E Soto, F Gaete, P Peñaloza, M Celis & G I Owen (Source: International Journal of Obesity)

HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers.

Cell Research — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E Abstract Tumor stroma drives the growth and progression of cancers. A heparin-binding epidermal growth factor-like growth factor, HB-EGF, is an EGF receptor ligand that stimulates cell growth in an autocrine or paracrine fashion. While elevated expression of HB-EGF in cancer cells and its contribution to tumor progression are well documented, the effects of HB-EGF expression in the tumor stroma have not been clarified. Here, we show that HB-EGF is expressed in stromal fibroblasts where it promotes cancer cell proliferation. In uterine cervical cancers, HB-EGF was detected immunohistochemically in the stroma proximal to the cancer epithelium. Proliferation of cerv...

Vaginal tumors in childhood: the experience of St. Jude Children's Research Hospital

Journal of Pediatric Surgery — Tue, 01 Nov 2011 04:00:00 +0100

Conclusions: Vaginal tumors are extremely rare in the pediatric population. Early recognition of symptoms like bleeding and a protruding vaginal mass may prevent morbidity and mortality. Our findings confirm the good prognosis of vaginal RMS. (Source: Journal of Pediatric Surgery)

Food safety involving ingestion of foods and beverages prepared with phthalate-plasticizer-containing clouding agents.

J Formos Med Assoc — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Yen TH, Lin-Tan DT, Lin JL Abstract In May 2011, the illegal use of the phthalate plasticizer di(2-ethylhexyl) phthalate in clouding agents for use in foods and beverages was reported in Taiwan. This food scandal has caused shock and panic among the majority of Taiwanese people and has attracted international attention. Phthalate exposure is assessed by ambient monitoring or human biomonitoring. Ambient monitoring relies on measuring chemicals in environmental media, foodstuff and consumer products. Human biomonitoring determines body burden by measuring the chemicals, their metabolites or specific reaction products in human specimens. In mammalian development, the fetus is set to develop into a female. Because the female phenotype is the default, impairment of testosteron...

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Opinions and expectations of women in the treatment of cervical and uterine cancer in Spain

Future Medicine: Women's Health — Mon, 31 Oct 2011 16:25:39 +0100

Women's Health , November 2011, Vol. 7, No. 6, Pages 709-718. (Source: Future Medicine: Women's Health)

Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes

Molecular Cancer — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: We conclude that the grade of genomic instability rather than the histopathological subtype correlates with specific gene and protein expression changes. The identified genes and proteins might be useful as molecular targets for improved diagnostic and therapeutic intervention and merit prospective validation. (Source: Molecular Cancer)

HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers

Cancer Research — Sun, 30 Oct 2011 04:00:00 +0100

Tumor stroma drives the growth and progression of cancers. A heparin-binding epidermal growth factor–like growth factor, HB-EGF, is an EGF receptor ligand that stimulates cell growth in an autocrine or paracrine fashion. While elevated expression of HB-EGF in cancer cells and its contribution to tumor progression are well documented, the effects of HB-EGF expression in the tumor stroma have not been clarified. Here, we show that HB-EGF is expressed in stromal fibroblasts where it promotes cancer cell proliferation. In uterine cervical cancers, HB-EGF was detected immunohistochemically in the stroma proximal to the cancer epithelium. Proliferation of cervical cancer cells in vitro was enhanced by coculture with fibroblasts isolated from tumor tissues of patients with cervical cancer. Inhi...

ARID1A, a Factor That Promotes Formation of SWI/SNF-Mediated Chromatin Remodeling, Is a Tumor Suppressor in Gynecologic Cancers

Cancer Research — Sun, 30 Oct 2011 04:00:00 +0100

ARID1A (BAF250A) promotes the formation of SWI/SNF chromatin remodeling complexes containing BRG1 or BRM. It has emerged as a candidate tumor suppressor based on its frequent mutations in ovarian clear cell and endometrioid cancers and in uterine endometrioid carcinomas. Here, we report that restoring wild-type ARID1A expression in ovarian cancer cells that harbor ARID1A mutations is sufficient to suppress cell proliferation and tumor growth in mice, whereas RNA interference–mediated silencing of ARID1A in nontransformed epithelial cells is sufficient to enhance cellular proliferation and tumorigenicity. Gene expression analysis identified several downstream targets of ARID1A including CDKN1A and SMAD3, which are well-known p53 target genes. In support of the likelihood that p53 mediates...

Uterine Corpus Tumors

Cancer Network — Fri, 28 Oct 2011 12:00:00 +0100

This treatment guide covers the epidemiology, etiology and risk factors, signs and symptoms, screening and diagnosis, pathology, staging and prognosis, and the treatment of endometrial cancer. It also covers the treatment of uterine sarcomas and gestational trophoblastic diseases. (Source: Cancer Network)

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Cervical Cancer

Cancer Network — Fri, 28 Oct 2011 12:00:00 +0100

Of the predominant gynecologic cancers, cancer of the uterine cervix is the least common, with only 12,200 new cases anticipated in the United States in 2010. Nevertheless, approximately 4,210 women die of cancer of the uterine cervix annually in the United States. (Source: Cancer Network)

Peritoneal keratin granuloma associated with endometrioid adenocarcinoma of the uterine corpus.

Diagnostic Pathology — Fri, 28 Oct 2011 04:00:00 +0100

We present a 69-year-old woman with a chief complaint of postmenopausal bleeding. She was diagnosed as having an endometrioid adenocarcinoma by biopsy, and underwent a total abdominal hysterectomy. At the time of surgery, granulation tissue-like nodules were found on the peritoneal serosa of the uterus. In the intraoperative cytology of peritoneal washing, atypical cells were noted. The intraoperative frozen section of the peritoneal nodule revealed granulation tissue with proliferating mesothelial cells. Microscopic examination of the permanent section showed keratin granulomas without viable adenocarcinoma cells on the serosal surface of the ovaries, fallopian tubes and broad ligaments. Postoperative chemotherapy was administered. She has been alive with no evidence of recurrence for 6 m...

Med Sci Monit 2011; 17(11):CR618-625 "Determination of CA-125 levels in the serum, cervical and vaginal secretions, and endometrium in Chinese women with precancerous disease or endometrial cancer"

Medical Science Monitor — Wed, 26 Oct 2011 17:52:00 +0100

Conclusions: Endo.metrial CA-125 expression together with its levels in the serum and cervical and vaginal secretions can be used as a potential biomarker in the diagnosis of precancerous diseases and endometrial carcinoma (Source: Medical Science Monitor)

Is imaging relevant for treatment choice in early stage cervical uterine cancer?

Surgical Oncology — Wed, 26 Oct 2011 04:00:00 +0100

Conclusion: Based on imaging, accurate selection of patients for treatment choice is still lacking in patients with early cervical cancer. (Source: Surgical Oncology)

JCOG Radiation Therapy Study Group: History and Achievements

Japanese Journal of Clinical Oncology — Tue, 25 Oct 2011 04:00:00 +0100

The Radiation Therapy Study Group (RTSG) of the Japan Clinical Oncology Group (JCOG) was established in 2003. The missions of this group are to develop new standards of care with innovative, advanced technology radiation therapy, both for single- and multi-modality cancer treatment, and to improve radiation therapy quality and outcomes of JCOG trials conducted by other organ-oriented groups. In 2004, the first RTSG trial, a Phase II study of stereotactic body radiation therapy for Stage IA non-small cell lung cancer (JCOG 0403), was initiated. Four other trials are currently open for accrual. JCOG 0702 is a Phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer. JCOG 0701 is a Phase III study comparing accelerated fractionation with conventi...

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Time Trends in Uterus Cancer Mortality Between 1955 and 2008 in Japan, USA and Europe Based on the WHO Mortality Database

Japanese Journal of Clinical Oncology — Tue, 25 Oct 2011 04:00:00 +0100

(Source: Japanese Journal of Clinical Oncology)

Postmenopausal estradiol‐progestagen therapy and risk for uterine cervical cancer

International Journal of Cancer — Tue, 25 Oct 2011 04:00:00 +0100

AbstractThe aim of this study was to evaluate the association of postmenopausal estradiol‐progestagen therapy (EPT) with the risk for precancerous lesions, squamous cell carcinoma and adenocarcinoma of the uterine cervix. All Finnish women who had used EPT in 1994‐2008 for at least 6 months (n=243,857) at the age of 50 years or more were identified from the national Medical Reimbursement Registry and linked to the Finnish Cancer Registry. The incidence of cervical precancerous or cancerous lesions among EPT users was compared to that in the background population. There were 210 EPT users with squamous lesions (178 with precancerous and 32 with cancer) and 79 EPT users with glandular lesions (14 precancerous and 65 adenocarcinomas). The ever use of EPT did not associate with the inciden...

Postmenopausal estradiol–progestagen therapy and risk for uterine cervical cancer

International Journal of Cancer — Tue, 25 Oct 2011 04:00:00 +0100

AbstractThe aim of this study was to evaluate the association of postmenopausal estradiol–progestagen therapy (EPT) with the risk for precancerous lesions, squamous cell carcinoma and adenocarcinoma of the uterine cervix. All Finnish women who had used EPT in 1994–2008 for at least 6 months (n = 243,857) at the age of 50 years or more were identified from the national Medical Reimbursement Registry and linked to the Finnish Cancer Registry. The incidence of cervical precancerous or cancerous lesions among EPT users was compared to that in the background population. There were 210 EPT users with squamous lesions (178 with precancerous and 32 with cancer) and 79 EPT users with glandular lesions (14 precancerous and 65 adenocarcinomas). The ever use of EPT did not associate with the incid...

Weight Gain Might Raise Endometrial Cancer Risk

MedlinePlus Health News — Mon, 24 Oct 2011 09:00:00 +0100

Extra pounds put on after menopause could up the odds, research suggests Source: HealthDay Related MedlinePlus Pages: Body Weight, Menopause, Uterine Cancer (Source: MedlinePlus Health News)

Postmenopausal Endometrial Bleeding

Ultrasound Clinics — Mon, 24 Oct 2011 04:00:00 +0100

Uterine bleeding in postmenopausal women is caused by endometrial atrophy, endometrial hyperplasia, endometrial polyp, submucosal leiomyoma, and endometrial cancer. Although most postmenopausal uterine bleeding is attributed to benign causes, the most common presenting symptom of endometrial cancer is uterine bleeding. Endovaginal sonography is generally accepted as an initial diagnostic tool to evaluate endometrium. It allows triaging patients who need endometrial biopsy and histologic diagnosis versus hysterosonography and hysteroscopy. Hysterosonography can be useful not only in the confirmation and characterization of focal endometrial pathologic conditions but it can also provide guidance to localize and treat focal endometrial pathologic conditions. (Source: Ultrasound Clinics)

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Extra Pounds Suspected in Raised Endometrial Cancer Risk

MedlinePlus Health News — Sun, 23 Oct 2011 23:00:00 +0100

Significant postmenopausal weight gain should be avoided, researcher urges Source: HealthDay Related MedlinePlus Pages: Body Weight, Menopause, Uterine Cancer (Source: MedlinePlus Health News)

Breast tenderness following combo hormone therapy linked to increased breast density

UCLA Newsroom: Health Sciences — Fri, 21 Oct 2011 18:28:41 +0100

Post-menopausal women who experience breast tenderness after starting combination hormone therapy have a higher risk of breast cancer than women who don't, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center has shown. One reason for this, they now say, may be that these women's breasts are becoming more dense. Such new-onset tenderness was found to be more pronounced after the start of combination estrogen-and-progestin therapy than with estrogen therapy alone. The link between new-onset tenderness and changes in breast density also was more pronounced in women on combination therapy, said the study's first author, Dr. Carolyn Crandall, a UCLA professor of general internal medicine and a scientist with the Jonsson Cancer Center. Multiple population studies...

Obesity and perioperative outcomes in endometrial cancer surgery

Archives of Gynecology and Obstetrics — Fri, 21 Oct 2011 16:00:27 +0100

Conclusion Obesity increases surgical blood loss and operative time. However, obesity does not affect length of hospital stay, number of lymph nodes harvested, or perioperative complications in uterine cancer staging surgery. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-6DOI 10.1007/s00404-011-2116-2Authors Joseph T. Santoso, University of Tennessee-West Clinic, 1588 Union Avenue, Memphis, TN 38104, USAGinny Barton, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USAShannon Riedley-Malone, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USAJim Y. Wan, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN...

Multidetector computed tomography in the study of pancreatic metastases

La Radiologia Medica — Fri, 21 Oct 2011 15:59:16 +0100

Conclusions MDCT allowed pancreatic metastases characterisation in 70.5% of cases. The lesions were the manifestation of widely disseminated neoplastic disease, with the exception of metastases from RCC, which were exclusively located in the pancreas. Content Type Journal ArticleCategory Abdominal Radiology / Radiologia AddominalePages 1-9DOI 10.1007/s11547-011-0736-zAuthors G. Angelelli, DiMIMP, Sezione di Diagnostica per Immagini, Università degli Studi di Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyM. Mancini, DiMIMP, Sezione di Diagnostica per Immagini, Università degli Studi di Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyP. Pignataro, DiMIMP, Sezione di Diagnostica per Immagini, Università degli Studi di Bari, Piazza Giulio Cesare 11, 70124 Bari, Ital...

The Complexity of Hereditary Cancer Syndromes

Cancer Network — Wed, 19 Oct 2011 12:00:00 +0100

Counseling women at high risk for ovarian and uterine cancer is a complex process, from genetic diagnosis to the management of at-risk women. Rimes and colleagues have presented these challenging issues, and suggested ways to manage them, very well. (Source: Cancer Network)

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Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma.

Gynecologic Oncology — Tue, 18 Oct 2011 04:00:00 +0100

CONCLUSION: Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in patients with endometrial cancer. Future exploration of SNCG as a potential therapeutic target for selected patients could be of interest. PMID: 22015044 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Clinical outcome of patients with FIGO stage IA2 squamous cell carcinoma of the uterine cervix.

Gynecologic Oncology — Tue, 18 Oct 2011 04:00:00 +0100

CONCLUSION: We may conclude that conservative management of stage IA2 MIC is safe when exact evaluation of tumor extension and surgical margins of the cone are considered, and results in very low risk of recurrence, lymph node disease, and death caused by cancer. We believe that our experience will contribute to the achievement of the international consensus concerning the treatment of IA2 MIC. PMID: 22014630 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure - Effects in reproductive organs.

Chemosphere — Mon, 17 Oct 2011 04:00:00 +0100

Authors: Brunnberg S, Andersson P, Poellinger L, Hanberg A Abstract The dioxin/aryl hydrocarbon receptor (AhR) mediates most toxic effects of dioxins. In utero/lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) impairs fetal/neonatal development and the developing male reproductive tract are among the most sensitive tissues. TCDD causes antiestrogenic responses in rodent mammary gland and uterus and in human breast cancer cell lines in the presence of estrogen. Also, more recently an estrogen-like effect of TCDD/AhR has been suggested in the absence of estrogen. A transgenic mouse expressing a constitutively active AhR (CA-AhR) was developed as a model mimicking a situation of constant exposure to AhR agonists. Male and female reproductive tissues of CA-AhR mice wer...

Lobular endocervical glandular hyperplasia in a woman with Peutz–Jeghers syndrome: a case report

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 17 Oct 2011 04:00:00 +0100

Peutz–Jeghers syndrome (PJS) is an autosomal dominant genetic disease characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa. Rare genital tract tumors, such as Sertoli tumors of the testis, sex cord tumors with annular tubules, and minimal deviation adenocarcinoma (MDA), have been reported in patients with PJS . Most uterine cervical cancers in patients with PJS are MDA; few cases of lobular endocervical glandular hyperplasia (LEGH) in patients with PJS have been reported . The case reported here is of LEGH in an unmarried woman with PJS who was successfully treated by simple trachelectomy for fertility preservation. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)