MedWorm: Cancer

Omega 3 curbs precancerous growths in those prone to bowel cancer, study suggests

ScienceDaily Headlines — Sun, 21 Mar 2010 16:51:41 +0100

A purified form of an omega 3 cuts the number and size of precancerous bowel growths (polyps) in people whose genetic makeup predisposes them to bowel cancer, finds new research. (Source: ScienceDaily Headlines)

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Human Genome Sciences Announces Results of Randomized Phase 2 Trial of Mapatumumab in Non-Small Cell Lung Cancer

Drugs.com - Clinical Trials — Sun, 21 Mar 2010 13:55:42 +0100

ROCKVILLE, Md.--(BUSINESS WIRE)--Mar 17, 2010 - Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the results of its randomized Phase 2 trial of mapatumumab (HGS-ETR1) in combination with the chemotherapy agents paclitaxel and carboplatin... (Source: Drugs.com - Clinical Trials)

Biovest Announces Upcoming Conference Calendar to Present on Personalized Cancer Vaccine Targeting B-cell Lymphomas

Drugs.com - Clinical Trials — Sun, 21 Mar 2010 13:55:15 +0100

TAMPA, Fla. & MINNEAPOLIS--(BUSINESS WIRE)--Mar 17, 2010 - Biovest International, Inc. (Other OTC:BVTI) today announced that the company is confirmed to present its personalized cancer vaccine, BiovaxID®, at the following... (Source: Drugs.com - Clinical Trials)

Change of Address Changes Prognosis for Brain Cancer Patient

MedPage Today Public Health — Sun, 21 Mar 2010 13:13:14 +0100

In this second MedPage Today/Milwaukee Journal Sentinel special report, John Fauber describes an oncologist and his patients were successfully battling glioblastoma multiforme until Medicare bureaucracy reached out to her with disastrous consequences. (Source: MedPage Today Public Health)

Novelos Therapeutics Discontinues Current Development Program For NOV-002 In NSCLC

Health News from Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

Novelos Therapeutics, Inc. (OTCBB: NVLT), a biopharmaceutical company focused on the development of therapeutics to treat cancer and hepatitis, announced that primary and secondary endpoints were not met in Novelos' pivotal Phase 3 trial in advanced non-small cell lung cancer (NSCLC) with its lead product, NOV-002, in combination with first-line chemotherapy. Adding NOV-002 to paclitaxel and carboplatin chemotherapy was not statistically or meaningfully different in terms of efficacy-related endpoints or recovery from chemotherapy toxicity versus chemotherapy alone... (Source: Health News from Medical News Today)

Phase 2 Data On Provectus's PV-10 To Be Presented At The 2010 ASCO Scientific Program On June 4 - 8 In Chicago

Health News from Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development-stage oncology and dermatology biopharmaceutical company, announced that data from its Phase 2 study of PV-10 for metastatic melanoma has been accepted for presentation at the 2010 American Society of Clinical Oncology (ASCO) Scientific Program to be held on June 4 - 8, 2010 in Chicago, Illinois. Dr. Sanjiv Agarwala, Chief, Medical Oncology and Hematology at St. Luke's Hospital and Health Network in Bethlehem, PA, and Principal Investigator for Provectus's Phase 2 PV-10 trial site at St... (Source: Health News from Medical News Today)

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Joint Advocacy Conference Brings Urology's Voice To Capitol Hill

Health News from Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

The American Urological Association (AUA) and the American Association of Clinical Urologists (AACU) are pleased to once again co-sponsor the only advocacy meeting specifically devoted to urology. The Fifth Annual Urology Joint Advocacy Conference will be held March 21 through March 23 at the Ritz-Carlton, Washington, DC. One of the highlights of this year's conference will be the unveiling of two pieces of AUA-authored legislation focusing on prostate cancer and urotrauma... (Source: Health News from Medical News Today)

Novelos Therapeutics Discontinues Current Development Program For NOV-002 In NSCLC

Cancer / Oncology News From Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

Phase 2 Data On Provectus's PV-10 To Be Presented At The 2010 ASCO Scientific Program On June 4 - 8 In Chicago

Cancer / Oncology News From Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development-stage oncology and dermatology biopharmaceutical company, announced that data from its Phase 2 study of PV-10 for metastatic melanoma has been accepted for presentation at the 2010 American Society of Clinical Oncology (ASCO) Scientific Program to be held on June 4 - 8, 2010 in Chicago, Illinois. Dr... (Source: Cancer / Oncology News From Medical News Today)

Philips To Unveil Breakthrough In Digital Pathology

Cancer / Oncology News From Medical News Today — Sun, 21 Mar 2010 07:00:00 +0100

At the United States & Canadian Academy of Pathology 2010 annual meeting (March 20-26, Washington DC, USA), Royal Philips Electronics (NYSE: PHG, AEX: PHI) will unveil a work-in-progress pathology slide scanner and associated image management system. These prototype systems will form the basis of the company's future integrated digital pathology solutions... (Source: Cancer / Oncology News From Medical News Today)

Improving initial polyp candidate extraction for CT colonography.

Physica Medica — Sun, 21 Mar 2010 06:40:06 +0100

In this study, we introduce an improved scheme for segmenting IPCs. It consists of two main components. One is geodesic distance-based merging, which merges suspicious patches (SPs) for IPCs. Based on the merged SPs, another component, called convex dilation, grows each SP beyond the inner surface of the colon wall to form a volume of interest (VOI) for that IPC, so that the inner border of the VOI beyond the colon inner surface could be segmented as convex, as expected. The IPC segmentation strategy was evaluated using a database of 50 patient studies, which include 100 scans at supine and prone positions with 84 polyps and masses sized from 6 to 35 mm. The presented IPC segmentation strategy (or VOI extraction method) demonstrated improvements, in terms of having no undesirably merged tr...

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Women in science: Pioneers blaze path for others

The Independent - Science — Sun, 21 Mar 2010 06:15:18 +0100

They have mapped the infinity of space, developed spray-on skin for burns victims, pioneered cancer-beating therapies, created cutting-edge computer chips, discovered the first radio pulsars, and won Nobel prizes. But female science professors are still being asked to make the tea and take notes at meetings by their – often junior – male colleagues. (Source: The Independent - Science)

Role of the micro-environment in Barrett's carcinogenesis.

Biochemical Society Transactions — Sun, 21 Mar 2010 03:09:22 +0100

Authors: Lao-Sirieix P, Fitzgerald RC Most epithelial cancers occur on the background of chronic exposure to damaging agents which is reflected in the long lag phase from development of a pre-invasive lesion to the development of a carcinoma. Luminal refluxate has long been recognized to be associated with Barrett's oesophagus, although causal mechanisms have not been clearly defined. Recently, obesity and dietary nitric oxide have also been implicated in the disease pathogenesis. We have demonstrated that acid can alter cell kinetics and, together with nitric oxide, can induce double-stranded DNA breaks. Aside from exposure to luminal factors, the stromal micro-environment may also be important. There is increasing evidence to suggest that inflammatory pathways such as TGF (transformi...

New models of neoplastic progression in Barrett's oesophagus.

Biochemical Society Transactions — Sun, 21 Mar 2010 03:09:18 +0100

Authors: Pavlov K, Maley CC Research in Barrett's oesophagus, and neoplastic progression to OAC (oesophageal adenocarcinoma), is hobbled by the lack of good pre-clinical models that capture the evolutionary dynamics of Barrett's cell populations. Current models trade off tractability for realism. Computational models are perhaps the most tractable and can be used both to interpret data and to develop intuitions and hypotheses for neoplastic progression. Tissue culture models include squamous cell lines, Barrett's oesophagus cell lines and OAC cell lines, although it was recognized recently that BIC-1, SEG-1 and TE-7 are not true OAC cell lines. Some of the unrealistic aspects of the micro-environment in two-dimensional tissue culture may be overcome with the development of three-dimens...

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation.

Biochemical Society Transactions — Sun, 21 Mar 2010 03:08:57 +0100

Authors: Barros R, Camilo V, Pereira B, Freund JN, David L, Almeida R IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development. After setting the role played by CDX2 (Caudal-type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context. PMID: 20298183 [PubMed - in process] (Source: Biochemical Society Transactions)

The role of Cdx2 in Barrett's metaplasia.

Biochemical Society Transactions — Sun, 21 Mar 2010 03:08:51 +0100

Authors: Colleypriest BJ, Farrant JM, Slack JM, Tosh D Metaplasia (or transdifferentiation) is defined as the transformation of one tissue type to another. Clues to the molecular mechanisms that control the development of metaplasia are implied from knowledge of the transcription factors that specify tissue identity during normal embryonic development. Barrett's metaplasia describes the development of a columnar/intestinal phenotype in the squamous oesophageal epithelium and is the major risk factor for oesophageal adenocarcinoma. This particular type of cancer has a rapidly rising incidence and a dismal prognosis. The homoeotic transcription factor Cdx2 (Caudal-type homeobox 2) has been implicated as a master switch gene for intestine and therefore for Barrett's metaplasia. Normally, ...

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Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?

Biochemical Society Transactions — Sun, 21 Mar 2010 03:08:31 +0100

Authors: Graham TA, McDonald SA Recent investigations into Barrett's oesophagus at the level of individual crypts have found significant genetic heterogeneity within a single lesion. Furthermore, this genetic diversity has been shown to predict cancer development. In the present article, we review the genetic alterations implicated in disease progression in Barrett's oesophagus and discuss how genetic diversity could arise during tumorigenesis. Three arguments are discussed: a high mutation rate coupled with strong selection, clonal interaction driving progression, and a hitherto unidentified alteration that disrupts epithelial cell homoeostasis. Suggestions are made for future research to distinguish which of these theories is the predominant mechanism in Barrett's oesophagus-associat...

Patients left in the dark over life-saving drug tests

Guardian Unlimited Science — Sun, 21 Mar 2010 00:07:11 +0100

Red tape means that too few have access to details of clinical trialsTens of thousands of patients are missing life-saving treatments because they are not being told about vital research, according to a new report.The government has said it wants information about clinical trials to be made available to patients to give them the option of becoming involved. But a report in the British Medical Journal warns that the fragmented and bureaucratic system surrounding trials, and Whitehall's reluctance to change it, means that many remain in the dark.Taking part in medical research can give patients access to treatments that may not yet be available on the NHS. And studies show that patients are keen to be involved not just for their own benefit but to help others and advance scientific know...

Advances In Genetics Give Cancer Fight A Brighter Future

Cancercompass News: Breast Cancer — Sun, 21 Mar 2010 00:00:00 +0100

When the internal bleeding started, Ellen Pulhamus figured she might die soon. Then the 60- year-old Denver woman got the call she believes gave her the gift of time. A biopsy of the tumors from Pulhamus' lung cancer, which had spread to her abdomen, found a very specific rearrangement of genes inside the cancer cells. She was eligible to join a clinical trial at the University of Colorado Cancer Center, testing a drug made to target her particular gene mutation. (Source: Cancercompass News: Breast Cancer)

Rare ATM Gene Mutations, Plus Radiation, May Increase Risk Of A Second Breast Cancer

Cancercompass News: Breast Cancer — Sun, 21 Mar 2010 00:00:00 +0100

Certain rare mutations in the ataxia telangiectasia mutated (ATM) gene, combined with radiation exposure, may increase a woman's risk of developing a second cancer in the opposite breast, according to a study published onlineMarch 19 in theJournal of the National Cancer Institute. (Source: Cancercompass News: Breast Cancer)

Research Addresses Side Effects Of Head, Neck Cancer Treatment

Cancercompass News: Other Cancer — Sun, 21 Mar 2010 00:00:00 +0100

Spencer Heyer avoids eating hamburgers and grainy bread. Other than that, he pretty much eats everything else he wants. Anything but something hard, like hard meat, the Wilmington resident said. That's no small thing for Heyer, 74, who underwent treatment five years ago after discovering a lump on the side of his neck. (Source: Cancercompass News: Other Cancer)

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Introduction of laparoscopic colorectal cancer surgery in developing nations

British Journal of Surgery — Sun, 21 Mar 2010 00:00:00 +0100

No Abstract. (Source: British Journal of Surgery)

Cancer Survivors Gather For Uphill Battle

WDSU.com - Health — Sat, 20 Mar 2010 17:32:12 +0100

Cancer survivors gather near the Mississippi River to show in a very real way that cancer is an uphill battle. (Source: WDSU.com - Health)

Causes of Death and Incidence of Cancer in a Cohort of Australian Pesticide-Exposed Workers. - Macfarlane E, Benke G, Del Monaco A, Sim MR.

SafetyLit: All (Unduplicated) — Sat, 20 Mar 2010 15:31:11 +0100

PURPOSE: To determine the rates of mortality and of cancer incidence in a cohort of pesticide-exposed Australian workers. METHODS: The study cohort was assembled using records of former government occupational health surveillance programs. The cohort was t... (Source: SafetyLit: All (Unduplicated))

FDG-PET/CT findings of a metastatic pituitary tumor.

Cancer Imaging — Sat, 20 Mar 2010 15:02:03 +0100

Authors: Yashar I, Daniel E A, Yonglin P The authors report the fluorodeoxyglucose (FDG)-positron emission tomography(PET)/computed tomography (CT) findings of a rare case of growth hormone-secreting pituitary carcinoma with multiple metastatic lesions to the skeleton. A 31-year-old male had presented with acromegaly and had received transsphenoidal resection of a pituitary tumor and adjuvant radiotherapy. However, the tumor recurred with local invasions and the patient underwent more resections and adjuvant chemotherapy. Several months later, the patient developed rising levels of insulin-like growth factor 1 and whole-body FDG-PET/CT scanning revealed multiple hypermetabolic lesions throughout the skeleton compatible with metastasis. PMID: 20299302 [PubMed - in process] (Source: ...

Extrarenal malignant rhabdoid tumors: radiologic findings with histopathologic correlation.

Cancer Imaging — Sat, 20 Mar 2010 15:02:03 +0100

We present rare uterine and hepatic MRT and their computed tomography, magnetic resonance, and ultrasound imaging features with histopathologic correlation. Although the final diagnosis is based largely on histopathology, radiologists should include MRT in their differential considerations, regardless of tumor location, when they are dealing with an extremely aggressive tumor of early childhood. PMID: 20299301 [PubMed - in process] (Source: Cancer Imaging)

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The indeterminate adrenal lesion.

Cancer Imaging — Sat, 20 Mar 2010 15:02:03 +0100

Authors: Anju S, Jon W, Isaac R F, Rodney H R With the increasing use of abdominal cross-sectional imaging, incidental adrenal masses are being detected more often. The important clinical question is whether these lesions are benign adenomas or malignant primary or secondary masses. Benign adrenal masses such as lipid-rich adenomas, myelolipomas, adrenal cysts and adrenal haemorrhage have pathognomonic cross-sectional imaging appearances. However, there remains a significant overlap between imaging features of some lipid-poor adenomas and malignant lesions. The nature of incidentally detected adrenal masses can be determined with a high degree of accuracy using computed tomography (CT) and magnetic resonance imaging (MRI) alone. Positron emission tomography (PET) is also increasingly u...

Freezing out breast cancer

ScienceDaily Headlines — Sat, 20 Mar 2010 15:00:00 +0100

Interventional radiologists have opened the door to an encouraging potential future treatment for the nearly 200,000 women who are diagnosed with breast cancer in the United States each year: image-guided, multiprobe cryotherapy. In the first reported study, researchers were able to successfully freeze breast cancer in patients who refused surgery; the women did not have to undergo surgery after treatment to ensure that tumors had been killed. (Source: ScienceDaily Headlines)

Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancer

Endoscopy — Sat, 20 Mar 2010 14:17:15 +0100

EndoscopyDOI: 10.1055/s-0029-1244022 Endoscopic ultrasound (EUS) has been regarded as the most accurate staging tool in esophageal cancer. Staging results have a strong impact on the decision as to whether a patient should undergo endoscopic treatment, surgery alone, or neoadjuvant therapy. This retrospective study was conducted to analyze the accuracy of esophageal cancer staging using EUS.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)

Drug Combo Meets NSCLC Milestone

MedPage Today Hematology/Oncology — Sat, 20 Mar 2010 14:13:05 +0100

Nanoparticle albumin-bound paclitaxel (Abraxane) met a key milestone in a non-small cell lung cancer clinical trial, the drug's maker said. (Source: MedPage Today Hematology/Oncology)

African–American men better able to cope with prostate cancer diagnosis

MedWire News - Prostate Cancer — Sat, 20 Mar 2010 13:48:34 +0100

African–American men report better emotional well-being than White men following a prostate cancer diagnosis, according to the results of a US study. (Source: MedWire News - Prostate Cancer)

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Mitochondrial Genome Instability in Cancer

Karger Publishers — Sat, 20 Mar 2010 13:45:00 +0100

Cytogenet Genome Res (DOI:10.1159/000300567) (Source: Karger Publishers)

3rd Annual Kidney Cancer Symposium

Kidney Cancer Association — Sat, 20 Mar 2010 12:58:47 +0100

Beth Israel Deaconess 3RD ANNUAL KIDNEY CANCER SYMPOSIUM Friday, June 18, 2010 8:30am – 3:00pm EDT Newton-Marriott Hotel 2345 Commonwealth Avenue Newton, Mass. 02466 Register: 617-632-9270 03/01/2010 (Source: Kidney Cancer Association)

Here's What's Wrong With ObamaCare

Kidney Cancer Association — Sat, 20 Mar 2010 12:40:00 +0100

03/22/2010 (Source: Kidney Cancer Association)

A Way Out of Soviet-Style Health Care

Kidney Cancer Association — Sat, 20 Mar 2010 12:36:54 +0100

Solzhenitsyn's prophetic warning about the depersonalization of medicine. The following is excerpted from an article with the same headline by Nobel Prize winning economist Milton Friedman that was published in the Wall Street Journal on April 17, 1996. Friedman died in 2006.03/22/2010 (Source: Kidney Cancer Association)

Now for the Slaughter

Kidney Cancer Association — Sat, 20 Mar 2010 12:33:47 +0100

Excuse me, but it is embarrassingreally, embarrassing to our countrythat the president of the United States has again put off a state visit to Australia and Indonesia because he's having trouble passing a piece of domestic legislation he's been promising for a year will be passed next week. What an air of chaos this signals to the world. And to do this to Australia of all countries, a nation that has always had America's back and been America's friend. 03/21/2010 (Source: Kidney Cancer Association)

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The ObamaCare Crossroads

Kidney Cancer Association — Sat, 20 Mar 2010 12:31:39 +0100

The vote is really about who commands the country's medical resources.03/21/2010 (Source: Kidney Cancer Association)

EDITORIAL: Hiding the true cost of Obamacare

Kidney Cancer Association — Sat, 20 Mar 2010 12:30:36 +0100

President Obama keeps saying America needs the Democrats' health care bill to reduce costs. In reality, the government takeover of health care will raise costs and cause a large number of people to lose their health insurance.03/21/2010 (Source: Kidney Cancer Association)

Health-Bill Horse Trading

Kidney Cancer Association — Sat, 20 Mar 2010 12:28:59 +0100

A frenzy of demands and last-minute deal-making threatened to gum up the Democrats' push to pass their landmark health bill Sunday, as wavering House members sought support for favored causes and home-state concerns before signing on.03/21/2010 (Source: Kidney Cancer Association)

Prometheus And Bayer Schering Pharma To Apply Novel Diagnostic Platform To Oncology Therapeutic Candidates

Health News from Medical News Today — Sat, 20 Mar 2010 09:00:00 +0100

Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced the execution of a research collaboration and license agreement with Bayer Schering Pharma AG, Germany, a worldwide leading specialty pharmaceutical company. The collaboration partners Prometheus' proprietary oncology diagnostic platform with Bayer's broad oncology pipeline in an effort to stratify patients to appropriate drug candidates and potentially accelerate the development of novel oncology therapeutic products... (Source: Health News from Medical News Today)

Evidence-Based Protocols In Cancer Treatment Reduce Variation, Improve Efficacy And Safety Of Care

Health News from Medical News Today — Sat, 20 Mar 2010 09:00:00 +0100

MedSolutions, a leading provider of medical cost management services, announced the launch of its oncology management program, which uses evidence-based guidelines to ensure appropriate use of diagnostic imaging, radiation therapy and drugs for cancer patients. "There is a vast and expanding body of research on cancer care, and doctors are understandably challenged to keep up with innovations in technology and best practices in treatment," said Gregg Allen, M.D., MedSolutions' chief medical officer. "This is further complicated by the number of new cancer cases in the U.S... (Source: Health News from Medical News Today)

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Prometheus And Bayer Schering Pharma To Apply Novel Diagnostic Platform To Oncology Therapeutic Candidates

Cancer / Oncology News From Medical News Today — Sat, 20 Mar 2010 09:00:00 +0100

Evidence-Based Protocols In Cancer Treatment Reduce Variation, Improve Efficacy And Safety Of Care

Cancer / Oncology News From Medical News Today — Sat, 20 Mar 2010 09:00:00 +0100

Feedback loop explains inflammatory effect on intestinal lining

ScienceDaily Headlines — Sat, 20 Mar 2010 09:00:00 +0100

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells. Researchers have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations. Interfering with one component of the feedback loop -- a protein called "dickkopf 1" -- may aid in controlling inflammatory bowel diseases. (Source: ScienceDaily Headlines)

Accelerating The Pace Of Discovery In Cancer Research

Health News from Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

Moffitt Cancer Center and Proteacel LLC have announced that they have entered a licensing agreement under which Proteacel has acquired the exclusive rights to the PORE™ technology for delivery of genes into cells. Genes are the instructions that build cells. Defects in these genes cause disease, such as cancer. In order to understand how these genes work and their involvement in a disease process, researchers must study and modify them. The most common way to study gene function is to transfer the gene into cells... (Source: Health News from Medical News Today)

Duke Cell Therapy Center Benefit From Robertson Foundation Donation

Health News from Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

A $10.2 million commitment from the Robertson Foundation to create a state-of-the-art Translational Cell Therapy Center (TCTC) will advance Duke Medicine's pioneering cell therapy research and treatment programs for children and adults with cancer, cerebral palsy, stroke and brain injuries suffered at birth. In making the announcement, Victor J... (Source: Health News from Medical News Today)

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Accelerating The Pace Of Discovery In Cancer Research

Cancer / Oncology News From Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

Duke Cell Therapy Center Benefit From Robertson Foundation Donation

Cancer / Oncology News From Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

Reduction of smoking in Dutch adolescents over the past decade and its health gains: a repeated cross-sectional study

The European Journal of Public Health — Sat, 20 Mar 2010 07:45:28 +0100

Conclusion: This study found that, in the past decade, smoking prevalence among adolescents has declined by almost 50%, potentially resulting in a considerable reduction in new cases of COPD or lung cancer. (Source: The European Journal of Public Health)

A cost-utility analysis of adding a bivalent or quadrivalent HPV vaccine to the Irish cervical screening programme

The European Journal of Public Health — Sat, 20 Mar 2010 07:45:28 +0100

Conclusion: HPV vaccination has the potential to be very cost effective in Ireland. The quadrivalent vaccine is more cost effective than the bivalent vaccine. (Source: The European Journal of Public Health)

The Impact Of Positive Surgical Margins On Mortality Following Radical Prostatectomy During The Prostate Specific Antigen Era

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

UroToday.com - A positive surgical margin (PSM) after radical prostatectomy (RP) for prostate cancer (CaP) is a known risk factor for disease progression. A PSM is reported to occur in 19%-50% of patients undergoing RP. In most studies, biochemical recurrence (BCR) is the primary endpoint used to assess the impact of margin status. A report from the Mayo Clinic that appears in the online edition of the Journal of Urology evaluates the incidence and clinicopathologic features associated with a PSM during the PSA era... (Source: Health News from Medical News Today)

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Inflammatory Effect On Intestinal Lining Explained By Feedback Loop

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a significantly higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells. Researchers at Emory University School of Medicine have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations... (Source: Health News from Medical News Today)

Further Benefits Of Noscapine For Prostate Cancer Revealed By Study

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

New research has revealed a major breakthrough in the use of cough medicine ingredient noscapine as a prophylactic treatment for prostate cancer. The study shows that noscapine inhibited tumor growth in mice and also limited the spread of tumors without causing any side effects. The collaborative pre-clinical laboratory research was conducted by Dr. Israel Barken, of the Prostate Cancer Research and Education Foundation (PCREF), Moshe Rogosnitzky, of the MedInsight Research Institute and Dr. Jack Geller, of the University of California San Diego... (Source: Health News from Medical News Today)

Increased Polyp Detection Rates With Third Eye Retroscope

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Two new studies show an increase in polyp detection rates using the Third Eye Retroscope (TER), a retrograde viewing device, during colonoscopy. The first study found that TER added to standard colonoscopy detected 13.2 percent more polyps than colonoscopy alone, including 11 percent additional adenomas (precancerous polyps). A second study examined endoscopist experience using TER and its impact on polyp detection rates, concluding that polyp detection rates improved significantly with TER... (Source: Health News from Medical News Today)

GenWay Signs Exclusive Agreement To Offer The You Test You Cancer Assessment In Greece

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

GenWay Biotech, Inc., the US-based diagnostic company that recently launched the You Test YouTM Cancer Assessment is expanding this cancer testing program internationally. An agreement has been executed to offer the You Test You*trade; Cancer Assessment in Greece starting in April. Additional agreements are in progress for other European nations as well. GenWay currently offers this test in the United States and Canada. Dr... (Source: Health News from Medical News Today)

Inflammatory Effect On Intestinal Lining Explained By Feedback Loop

Immune System / Vaccines News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

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GenWay Signs Exclusive Agreement To Offer The You Test You Cancer Assessment In Greece

Cancer / Oncology News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

GenWay Biotech, Inc., the US-based diagnostic company that recently launched the You Test YouTM Cancer Assessment is expanding this cancer testing program internationally. An agreement has been executed to offer the You Test You*trade; Cancer Assessment in Greece starting in April. Additional agreements are in progress for other European nations as well... (Source: Cancer / Oncology News From Medical News Today)

Increased Polyp Detection Rates With Third Eye Retroscope

Medical Devices News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Two new studies show an increase in polyp detection rates using the Third Eye Retroscope (TER), a retrograde viewing device, during colonoscopy. The first study found that TER added to standard colonoscopy detected 13.2 percent more polyps than colonoscopy alone, including 11 percent additional adenomas (precancerous polyps)... (Source: Medical Devices News From Medical News Today)

The Impact Of Positive Surgical Margins On Mortality Following Radical Prostatectomy During The Prostate Specific Antigen Era

Prostate News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Further Benefits Of Noscapine For Prostate Cancer Revealed By Study

Prostate News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Minimally invasive surgery versus open surgery for the treatment of solid abdominal and thoracic neoplasms in children.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: No RCTs or CCTs evaluating MIS in the treatment of solid intra-thoracic or intra-abdominal neoplasms in children could be identified, therefore no definitive conclusions could be made about the effects of MIS in these patients. Based on the currently available evidence we are not able to give recommendations for the use of MIS in the treatment of solid intra-thoracic or intra-abdominal neoplasms in children. More high quality studies (RCTs and/or CCTs) are needed. To accomplish this, centres specialising in MIS in children should collaborate. PMID: 20238368 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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Angiogenesis-inhibitors for metastatic thyroid cancer.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: There is currently no reliable evidence available from randomized controlled trials regarding the bene fi ts and harms of the use of angiogenesis-inhibitors for treating advanced thyroid cancer. Several trials are ongoing. PMID: 20238360 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: There is not sufficient evidence to determine the optimal method of enteral feeding for patients with head and neck cancer receiving radiotherapy and/or chemoradiotherapy. Further trials of the two methods of enteral feeding, incorporating larger sample sizes, are required. PMID: 20238358 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Surgical management of localised renal cell carcinoma.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: The main source of evidence for the current practice of laparoscopic excision of renal cancer is drawn from case series, small retrospective studies and very few small randomised controlled trials. The results and conclusions of these studies must therefore be interpreted with caution. PMID: 20238346 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: The limited number of patients available for analysis, methodological flaws and a significant over-representation of patients with FIGO stage IIIB prohibit drawing definite conclusions regarding the impact of adding hyperthermia to standard radiotherapy. However, available data do suggest that the addition of hyperthermia improves local tumour control and overall survival in patients with locally advanced cervix carcinoma without affecting treatment related grade 3 to 4 acute or late toxicity. PMID: 20238344 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Different anthracycline derivates for reducing cardiotoxicity in cancer patients.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: We are not able to favour either epirubicin or doxorubicin when given with the same dose. Based on the currently available evidence on heart failure, we conclude that in adults with a solid tumour liposomal-encapsulated doxorubicin should be favoured over doxorubicin. For both epirubicin versus doxorubicin and liposomal-encapsulated doxorubicin versus conventional doxorubicin no conclusions can be made about the effects of treatment in children treated with anthracyclines and also not in patients diagnosed with leukaemia. More research is needed. For other combinations of anthracycline derivates not enough evidence was available to make definitive conclusions about the occurrence of cardiotoxicity in patients treated with anthracyclines. PMID: 20238335 [PubMed - in process...

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Chemotherapy for advanced gastric cancer.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: Chemotherapy significantly improves survival in comparison to best supportive care. In addition, combination chemotherapy improves survival compared to single-agent 5-FU. All patients should be tested for their HER-2 status and trastuzumab should be added to a standard fluoropyrimidine/cisplatin regimen in patients with HER-2 positive tumours. Two and three-drug regimens including 5-FU, cisplatin, with or without an anthracycline, as well as irinotecan or docetaxel-containing regimens are reasonable treatment options for HER-2 negative patients. PMID: 20238327 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Tamoxifen for relapse of ovarian cancer.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: We are unable to make any evidence-based recommendations as we found no comparative studies assessing the effectiveness of tamoxifen in women with recurrent ovarian cancer. There is limited evidence on anti-tumour activity from phase 2 studies, but these contain no data on the effect of tamoxifen on symptom control, QOL or the prolongation of life. PMID: 20238312 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Hepatitis C: What happens in end-stage liver disease?

MayoClinic.com Full Feed — Sat, 20 Mar 2010 05:00:00 +0100

End-stage complications of hepatitis C include liver failure and liver cancer. (Source: MayoClinic.com Full Feed)

Current role of hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from colorectal cancer.

World Journal of Gastroenterology : WJG — Sat, 20 Mar 2010 04:49:08 +0100

Authors: Rampone B, Schiavone B, Martino A, Confuorto G Peritoneal carcinomatosis is one of the most common routes of dissemination of colorectal cancer (CRC). It is encountered in 7% of patients at primary surgery, while it develops in about 4% to 19% of patients after curative surgery and in up to 44% of patients with recurrent CRC. Peritoneal involvement from colorectal malignancies has been considered traditionally as a manifestation of terminal disease, due to limited response to conventional surgical and chemotherapeutic treatments. In the past few years the introduction of cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion has shown promising results in selected patients. Currently, the surgical management of peritoneal surface malignancies of coloni...

Alcohol, nutrition and liver cancer: Role of Toll-like receptor signaling.

World Journal of Gastroenterology : WJG — Sat, 20 Mar 2010 04:48:46 +0100

This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors, S-adenosylmethionine and betaine, prevent the upregulation of the TLR signaling pathways and abrogate the stem cell/progenitor proliferation response when fed with the c...

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Effects on the pouch of different digestive tract reconstruction modes assessed by radionuclide scintigraphy.

World Journal of Gastroenterology : WJG — Sat, 20 Mar 2010 04:48:21 +0100

CONCLUSION: Dual Braun type esophagojejunal anastomosis is the most useful of the three procedures for improving food accommodation in patients with a pouch and can retard evacuation of solid food from the reconstructed pouch. PMID: 20238408 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Role of BMP3 in progression of gastric carcinoma in Chinese people.

World Journal of Gastroenterology : WJG — Sat, 20 Mar 2010 04:48:18 +0100

CONCLUSION: Promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people. PMID: 20238409 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

NO to Breast: When, Why and Why Not?

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Pervin S, Chaudhuri G, Singh R Nitric oxide is a pleiotropic ancestral molecule, which elicits beneficial effect in many physiological settings but is also tenaciously expressed in numerous pathological conditions, particularly breast tumors. Nitric oxide is particularly harmful in adipogenic milieu of the breast, where it initiates and promotes tumorigenesis. Epidemiological studies have associated populations at a greater risk for developing breast cancer, predominantly estrogen receptor positive tumors, to express specific polymorphic forms of endothelial nitric oxide synthase, that produce sustained low levels of nitric oxide. Low sustained nitric oxide generates oxidative stress and inflammatory conditions at susceptible sites in the heterogeneous microenvironment of the ...

The dual role of nitric oxide in glioma.

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Badn W, Siesjö P Malignant gliomas bear the most dismal prognosis of all human cancers despite the progress in therapy of many other tumors. The search for alternative and complementary treatments has therefore a high priority. Emerging knowledge of the dual and diverging role of nitric oxide in glioma biology has focused on possibilities to achieve anti-glioma effects by modulation of nitric oxide (NO) release and function in these tumors. NO has been shown to influence proliferation of glioma cells, vascular function in glioams, invasive capacity of gliomas, effects of chemo and radiotherapy and also immune reactivity against these tumors. The mechanisms behind the reported diverse and dual effects of NO in glioma biology are multiple. Some of the diversity can be expla...

Nitric oxide and pancreatic cancer pathogenesis, prevention, and treatment.

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Wang L, Xie K Pancreatic cancer is hallmarked by aggressive biology and extreme lethality and very high mortality rates. The underlying molecular mechanism of its rapid development and progression is unclear, however. Recent identification and functional validation of nitric oxide (NO) production in pancreatic cancer suggest a role for NO in the pathogenesis of this disease. Conceivably, overproduction of NO imposes an adverse selection pressure on the tumor microenvironment, which causes genetic and epigenetic changes in tumor and tumor stromal cells and promotes the evolution of these cells into more malignant cells conferred with a tremendous survival and growth advantage. Designing effective strategies targeting NO to control pancreatic cancer development and progression r...

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Nitric oxide in cancer therapeutics: interaction with cytotoxic chemotherapy.

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Hirst D, Robson T Nitric oxide is a key second messenger in most tissues, where it is generated at low concentrations, predominantly by the catalytic action of two constitutively expressed isoforms of nitric oxide synthase (NOS). Both of these are found in tumours, but malignancy is also associated with the expression of high levels of the inducible isoform of NOS, which is responsible for generation of high NO() concentrations, not associated with normal physiology. This has profound consequences for the aetiology and malignant progression of primary cancer and metastatic dissemination. It also ensures that tumour vasculature remains highly dilated, so maintaining the abnormally high growth rates, characteristic of malignant disease. This dependency on NO() can be targeted th...

Targeting the L-arginine-nitric oxide pathway for cancer treatment.

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Ma Q, Wang Z, Zhang M, Hu H, Li J, Zhang D, Guo K, Sha H The action of L-arginine is mainly dependent on its end-product, nitric oxide (NO). The L-arginine/NO pathway has been confirmed to play an important role in tumor development. Recent findings indicate that NO derived from L-arginine could influence angiogenesis factors, vascular permeability, perivascular-cell recruitment and vessel remodeling and maturation. Additionally, the L-arginine/NO pathway could activate a broad array of genes that are functionally involved in proliferation, metastasis and apoptosis. Interestingly, this pathway plays roles in both tumorigensis and tumor killing. The role of the L-arginine/NO pathway in tumor therapy has been well-studied. Members of this pathway have been reported to be promisi...

Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes.

Current Pharmaceutical Design — Sat, 20 Mar 2010 02:36:03 +0100

Authors: Hickok JR, Thomas DD The role of nitric oxide (NO()) as a mediator of cancer phenotype has led researchers to investigate strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain. Unfortunately, NO() serves multiple functions in cancer physiology. In some instances, NO() or nitric oxide synthase (NOS) levels correlate with tumor suppression and in other cases they are related to tumor progression and metastasis. Understanding this dichotomy has been a great challenge for researchers working in the field of NO() and cancer therapy. Due to the unique chemical and biochemical properties of NO(), it's interactions with cellular targets and the subsequent downstream signaling events can be vastly different based upon tumor heteroge...

Obesity’s role in cancer

L.A. Times - Health — Sat, 20 Mar 2010 02:04:23 +0100

It may not cause the disease, but studies show a link between fat and certain types. Packing on the pounds gets a well-deserved bad rap. Most Americans understand that excess weight contributes to heart disease and diabetes, not to mention the urge to hide behind the kids in family photos. But obesity as a risk factor for cancer? (Source: L.A. Times - Health)

Dense lymphocytic infiltrates associated with non-melanoma skin cancer in patients with chronic lymphocytic leukemia.

Dermatol Online J — Sat, 20 Mar 2010 01:42:03 +0100

We report a series of three cases of SCC with a coexisting infiltrate of CLL, including one with perineural involvement, one involving metastatic SCC, and one in which this histologic finding spurred the initial diagnosis of CLL. PMID: 20233561 [PubMed - in process] (Source: Dermatol Online J)

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Vaccine may stop cervical cancer return

Health News - UPI.com — Sat, 20 Mar 2010 00:56:56 +0100

BIRMINGHAM, Ala., March 19 (UPI) -- U.S. researchers said the vaccine to prevent cervical cancer may also protect against post-surgical recurrence of the disease. (Source: Health News - UPI.com)

Advising soaps

BBC News | Health | UK Edition — Sat, 20 Mar 2010 00:08:11 +0100

'Nursing' Corrie star through breast cancer (Source: BBC News | Health | UK Edition)

Cancer scans delayed in NHS funding crisis as doctors fear 'slash and burn' cuts

the Mail online | Health — Sat, 20 Mar 2010 00:02:36 +0100

Vital scans for patients who may have cancer are being postponed by up to six weeks as the NHS grapples with a major funding crisis. (Source: the Mail online | Health)

Setback for cancer test hopes

BBC News | Health | UK Edition — Sat, 20 Mar 2010 00:01:13 +0100

Testing for a virus linked with cervical cancer during traditional screening does not help identify high risk women, say doctors. (Source: BBC News | Health | UK Edition)

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Cancer Control — Sat, 20 Mar 2010 00:00:08 +0100

Authors: Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase recruited to integrin-mediated matrix attachment sites where FAK activity is implicated in the control of cell survival, migration and invasion. Although genetic studies support the importance of FAK activity in promoting tumor progression, it remains unclear whether pharmacological FAK inhibition prevents tumor metastasis. Here, we show that the FAK inhibitor PND-1186 blocks FAK Tyr-397 phosphorylation in vivo and exhibits anti-tumor efficacy in orthotopic breast carcinoma mouse tumor models. PND-1186 (100 mg/kg intraperitoneal, i.p.) showe...

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Debate Continues Over Best Way To Screen For Prostate Cancer

OrlandoSentinel: Medical Research — Sat, 20 Mar 2010 00:00:00 +0100

As a boy, Ophni Davis dreamed of becoming a doctor. Instead, he became a barber. But he still considers it his job to look after people's welfare. So if a man who looks about the right age comes into his Blue Hills Avenue salon in Hartford, Davis will... (Source: OrlandoSentinel: Medical Research)

Bcl-XL and STAT3 mediate malignant actions of γ-irradiation in lung cancer cells

Cancer Science — Sat, 20 Mar 2010 00:00:00 +0100

Previous reports suggest that, in addition to its therapeutic effects, ionizing radiation (IR) increases the invasiveness of surviving cancer cells. Here, we demonstrate that this activity of IR in lung cancer cells is mediated by a signaling pathway involving p38 kinase, phosphoinositide 3-kinase, Akt, and matrix metalloproteinase (MMP-2). The invasion-promoting doses of IR also increased and reduced the levels of vimentin and E-cadherin, respectively, both of which are markers for the epithelial[ndash]mesenchymal transition (EMT). Interestingly, all of these malignant actions of IR were mimicked by the overexpression of Bcl-XL, a pro-survival member of the Bcl-2 family, in lung cancer cells. Moreover, both RNA and protein levels of Bcl-XL were elevated upon irradiation of the cells, and ...

survivalratebystage

About.com Colon Cancer — Sat, 20 Mar 2010 00:00:00 +0100

Colon cancer survival rates vary by stage. Getting the facts about survival rates by stage will help you make informed decisions about your colon cancer care. When diagnosed early, colon cancer is highly curable. Even when diagnosed at later stages, new colon cancer treatments are improving survival for people with more advanced disease. (Source: About.com Colon Cancer)

Effect of simplification from protease inhibitors to boosted atazanavir-based regimens in real-life conditions

HIV Medicine — Sat, 20 Mar 2010 00:00:00 +0100

Atazanavir (ATV) boosted with ritonavir (ATV/r) is a potent, well-tolerated, once-daily protease inhibitor (PI). Few data are available on this agent as a treatment simplification option for patients taking other PIs. The aim of the study was to determine the effectiveness and safety of ATV-containing regimens in patients who have simplified their antiretroviral treatment. SIMPATAZ was a multicentre, prospective, noninterventional study in patients who had undetectable HIV RNA on their current PI-containing therapy and who were switched to an ATV/r-based regimen. Patients underwent a routine physical examination, and data were collected on HIV RNA levels, CD4 cell counts, liver function, lipid parameters, adverse reactions, adherence to treatment and patient satisfaction. A total of 183 pa...

Colon Cancer Drugs Linked to Survival, Considerable Expense

Modern Medicine — Sat, 20 Mar 2010 00:00:00 +0100

New chemotherapy drugs for metastatic colon cancer are associated with longer survival, but at steep costs that Medicare may have difficulty covering in the future, according to research published online March 16 in the Archives of Internal Medicine. (Source: Modern Medicine)

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Liver resection: a regional hospital experience

ANZ Journal of Surgery — Sat, 20 Mar 2010 00:00:00 +0100

Conclusion: Resection provides the best hope of cure for patients with primary or secondary hepatic malignancy. With adequate expertise, liver resections can be performed safely in a regional hospital. (Source: ANZ Journal of Surgery)

Endoscopic extraperitoneal radical prostatectomy: critical analysis of outcomes and learning curve

BJU International — Sat, 20 Mar 2010 00:00:00 +0100

Study Type [ndash] Therapy (case series)Level of Evidence 4OBJECTIVE To assess the outcomes and learning curve of extraperitoneal endoscopic radical prostatectomy (EERP) using cumulative summation charts from a single tertiary referral centre.PATIENTS AND METHODS The data from 300 consecutive men with localized prostate cancer who underwent EERP at Western General Hospital, Edinburgh, UK, between February 2006 and July 2009 were prospectively maintained in a database. The data collected included demographic details, perioperative outcomes, complications and follow-up for functional and oncology outcomes. The learning curve was analysed using generalized linear models for complication rate, operative time and blood loss, using procedure experience.RESULTS The mean (sd, range) operative dura...

Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent

Molecular Carcinogenesis — Sat, 20 Mar 2010 00:00:00 +0100

Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the involvement of additional modifier genes and/or environmental factors. Somatic inactivating mutations in the p53 gene and genes of the p53 pathway often accompany BRCA1/2-associated tumors. Therefore, we assessed whether these genes are modifiers of penetrance. We genotyped Jewish-Ashkenazi women for functional single-nucleotide polymorphisms (SNPs) in the AKT1 (C>T rs3730358) and the PERP (C>T rs2484067) genes that affect p53-mediated apoptosis, as well as two tag-SNPs in the CHEK2 (C>T rs743184) and the ZBRK...

Phase I Trial of Gemcitabine Dose Escalation with Concurrent Radiotherapy for Patients with Locally Advanced Pancreatic Cancer

Karger Publishers — Fri, 19 Mar 2010 23:00:00 +0100

Pancreatology 2010;10:6065 (DOI:10.1159/000231978) (Source: Karger Publishers)

Topographical Sensitivity and Specificity of Endorectal Coil Magnetic Resonance Imaging for Prostate Cancer Detection

Karger Publishers — Fri, 19 Mar 2010 23:00:00 +0100

Urol Int (DOI:10.1159/000300572) (Source: Karger Publishers)

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FDA Announces New Rules to Curb Youth Smoking

American Cancer Society :: News and Features — Fri, 19 Mar 2010 22:01:03 +0100

The Food and Drug Administration (FDA) has announced new rules making it harder for tobacco companies to target children and young teens. (Source: American Cancer Society :: News and Features)

Nuclear Commission fines VA over botched prostate cancer radiation therapies

Scientific American Topic - Medical Technology — Fri, 19 Mar 2010 21:55:00 +0100

The U.S. Department of Veterans Affairs (VA) is being fined for botching 97 of 116 procedures to treat prostate cancer among men seeking care at the agency's medical center in Philadelphia. Although the punishment, which adds up to a mere $227,500, might not sound like more than a slap on the wrist, it is coming from the Nuclear Regulatory Commission (NRC) and is one of the largest the commission has ever given out for medical mistakes. [More] (Source: Scientific American Topic - Medical Technology)

Nuclear Commission fines VA over botched prostate cancer radiation therapies

Scientific American - Official RSS Feed — Fri, 19 Mar 2010 21:55:00 +0100

Clinical Trials and Translational Research Advisory Committee

Videocast - All Events — Fri, 19 Mar 2010 20:53:00 +0100

Presented by: Coordinating Center for Clinical Trials, National Cancer InstituteCategory: Advisory BoardsAired date: 03/19/2010 (Source: Videocast - All Events)

NCCN Guideline on Occult Cancer Show Immunohistochemistry Is "Rapidly Changing"

Medscape Today Headlines — Fri, 19 Mar 2010 19:26:15 +0100

The outstanding change in the NCCN update of its guideline for cancer of an unknown primary origin is in the new immunohistochemical markers. Medscape Medical News (Source: Medscape Today Headlines)

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Mesothelioma Treatment Including Photodynamic Therapy Shows Promise in Recent Study

Asbestos and Mesothelioma News — Fri, 19 Mar 2010 18:40:59 +0100

A study published in Seminars in Thoracic and Cardiovascular Surgery investigated the inclusion of photodynamic therapy in multimodality treatment for mesothelioma cancer. Malignant mesothelioma is an aggressive cancer that rarely responds to current treatment methods. Caused almost exclusively by asbestos exposure, mesothelioma rarely responds to treatments such as chemotherapy, radiation or surgery. When these mesothelioma treatments are combined into a multimodality approach some extension in survival rates has been observed in certain mesothelioma patients, encouraging further research into multimodality treatment. Photodynamic therapy (PDT) of the pleura is in an experimental phase and aims to eliminate remaining microscopic cancerous tissue after complete surgical removal of the meso...

SGO: New Option for Recurrent Ovarian Cancer? (CME/CE)

MedPage Today Hematology/Oncology — Fri, 19 Mar 2010 18:19:19 +0100

SAN FRANCISCO (MedPage Today) -- Women with recurrent or relapsed, platinum-sensitive ovarian cancer had a significantly lower risk of subsequent recurrence and less toxicity when treated with carboplatin and pegylated liposomal doxorubicin (PLD, Doxil) than with standard therapy, data from a large European study showed. (Source: MedPage Today Hematology/Oncology)

Levact(R) (bendamustine) Recommended for Approval in Europe for Treating Blood Cancers

HSMN NewsFeed — Fri, 19 Mar 2010 17:59:03 +0100

CAMBRIDGE, England, March 19, 2010 (HSMN NewsFeed) -- Mundipharma announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending that marketing authorisatio... Biopharmaceuticals, Oncology, RegulatoryMundipharma, Levact, bendamustine, non-Hodgkin's lymphoma, leukemia, myeloma (Source: HSMN NewsFeed)

Renal tumour suppressor function of the Birt-Hogg-Dube syndrome gene product folliculin

Journal of Medical Genetics — Fri, 19 Mar 2010 17:53:08 +0100

Conclusion In accordance with clinical data showing distinct renal malignancies arising in BHD patients, in this study FLCN is shown as a general tumour suppressor in the kidney. (Source: Journal of Medical Genetics)

Small-molecule signal-transduction inhibitors: targeted therapeutic agents for single-gene disorders

Journal of Medical Genetics — Fri, 19 Mar 2010 17:53:07 +0100

Mutations affecting over 2000 of the 20 000 or so genes in the human genome have been linked so far to specific inherited diseases, most of which are rare and have been poorly understood. Many of the genes involved encode components of intracellular signalling pathways that regulate processes such as the growth, proliferation, differentiation and survival or programmed death of cells during development and the maintenance of tissues and organs. Mutations that change the function of genes encoding signalling proteins thereby cause disorders ranging from birth defects to cancer. For Mendelian disorders, the essentially causal relationship between mutation and disease may present direct opportunities to therapeutically manipulate intracellular signalling. Here, we review recent examples of th...

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A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum

Journal of Medical Genetics — Fri, 19 Mar 2010 17:53:07 +0100

Conclusion We provide evidence of a novel splice variant of the DNA-PKcs gene associated with radiosensitivity in a patient with xeroderma pigmentosum and report the first double mutant in distinct DNA repair pathways being consistent with viability. (Source: Journal of Medical Genetics)

Clinical application of a lectin-antibody ELISA to measure fucosylated haptoglobin in sera of patients with pancreatic cancer

Clinical Chemistry and Laboratory Medicine — Fri, 19 Mar 2010 17:52:47 +0100

Conclusions: While certain cases showed a discrepancy in fucosylated haptoglobin concentrations between the lectin-antibody ELISA and conventional lectin blotting, this novel type of lectin-antibody ELISA might be useful for a tumor marker for PC. Clin Chem Lab Med 2010;48:505–12. (Source: Clinical Chemistry and Laboratory Medicine)

Eczema Drugs May Need Wider Caution in Kids: FDA Staff

Medscape Dermatology Headlines — Fri, 19 Mar 2010 17:44:19 +0100

Drugs for eczema made by Novartis AG and Astellas Pharma may need their warning labels expanded after dozens of new reported cases of cancer and infection in children, U.S. Food and Drug Administration staff said in documents released on Thursday. Reuters Health Information (Source: Medscape Dermatology Headlines)

Security Scans: Too Much Radiation?

Dr. Weil Q&A — Fri, 19 Mar 2010 17:39:07 +0100

Aside from the privacy issue, I'm alarmed by the proposed use of full body scanners in airports to look for devices hidden under clothing. Won't the scans subject us to needless radiation that can cause cancer and pose other health risks? (Source: Dr. Weil Q&A)

HIPK2-A therapeutical target to be (re)activated for tumor suppression: Role in p53 activation and HIF-1alpha inhibition.

Cell Cycle — Fri, 19 Mar 2010 17:38:12 +0100

Authors: Nardinocchi L, Puca R, Givol D, D'Orazi G Oncosuppressor p53 is often inactivated by either mutations or deregulation of regulatory proteins. These include the homeodomain-interacting protein kinase 2 (HIPK2) that, by phosphorylating p53 at Ser46 modulates p53 response to DNA damage by inducing pro-apoptotic transcription. There is compelling evidence that HIPK2 is also involved in the response to hypoxia by acting as co-suppressor of hypoxia inducible factor 1alpha (HIF-1alpha), a major factor in cancer progression that activates the transcription of genes involved in angiogenesis, glucose metabolism and invasion. Hence conditions that induce HIPK2 deregulation would end up in a multifactorial response leading to tumor chemoresistance by affecting p53 activity on one hand and...

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Scripps, Moffitt share $2M grant

bizjournals.com Health Care:Biotechnology headlines — Fri, 19 Mar 2010 17:37:33 +0100

Researchers at the Scripps Research Institute in Jupiter and the H. Lee Moffitt Cancer Center in Tampa will share a nearly $2 million grant to work on cancer therapies. (Source: bizjournals.com Health Care:Biotechnology headlines)

SGO: No Lung CA Risk Seen with Estrogen (CME/CE)

MedPage Today Hematology/Oncology — Fri, 19 Mar 2010 17:33:21 +0100

SAN FRANCISCO (MedPage Today) -- Unopposed estrogen therapy (ERT) did not increase lung cancer incidence or mortality risk in the Women's Health Initiative (WHI). (Source: MedPage Today Hematology/Oncology)

Estrogens, regulation of p53 and breast cancer risk: a balancing act.

Cellular and Molecular Life Sciences : CMLS — Fri, 19 Mar 2010 17:22:12 +0100

Authors: Jerry DJ, Dunphy KA, Hagen MJ The paradoxical effects of ovarian hormones in both the promotion and prevention of breast cancer have been debated for over 30 years. Genetic studies have demonstrated that ovarian hormones act through NF-kappaB to stimulate proliferation and ductal elongation, whereas the p53 tumor suppressor protein plays a central role in rendering the mammary epithelium resistant to tumorigenesis. Transcriptional profiles now suggest that ovarian hormones stimulate a constellation of genes that interact with NF-kappaB and p53 to arbitrate the competing demands for proliferation and surveillance. Genes that participate in chromatin remodeling are among the acute transcriptional responses to estrogens and progestins. These genes are proposed to initiate epigene...

Moffitt, Scripps get $2M National Cancer Institute grant

bizjournals.com Health Care:Biotechnology headlines — Fri, 19 Mar 2010 17:22:02 +0100

Researchers at H. Lee Moffitt Cancer Center & Research Institute and Scripps Florida were awarded a five-year, nearly $2 million grant from the National Cancer Institute. (Source: bizjournals.com Health Care:Biotechnology headlines)

More study needed on vitamin D-ovarian cancer link

Reuters: Health — Fri, 19 Mar 2010 17:21:57 +0100

NEW YORK (Reuters Health) - There isn't enough evidence to back or debunk the claim that vitamin D can help reduce the risk of ovarian cancer, despite several recent studies making this claim, the authors of a new review of the scientific literature conclude. (Source: Reuters: Health)

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Kinase inhibitors: Narrowing down the real targets

Nature Chemical Biology — Fri, 19 Mar 2010 17:19:34 +0100

Nature Chemical Biology 6, 249 (2010). doi:10.1038/nchembio.336 Author: Henrik Daub Many kinase inhibitors for cancer therapy are rather nonselective, and their cellular mechanisms of action are incompletely understood. A nested chemical proteomics and chemical genetics strategy reveals which cellular targets of the clinical kinase inhibitor dasatinib functionally relate to its anti-oncogenic activity. (Source: Nature Chemical Biology)

China battling with lifestyle-related diseases

Reuters: Health — Fri, 19 Mar 2010 17:19:27 +0100

HONG KONG (Reuters) - Chronic diseases such as strokes, cancer, and respiratory and heart conditions are China's biggest health problem, the health minister said on Friday, urging citizens to change lifestyle habits. (Source: Reuters: Health)

Infrared spectroscopy aids cancer diagnosis

Chemistry World | Latest News — Fri, 19 Mar 2010 17:13:24 +0100

A genetic algorithm developed by UK scientists could aid the use of infrared spectroscopy in cancer diagnosis (Source: Chemistry World | Latest News)

Cell Biology: Familial Ties in the Nucleus

Editors' Choice — Fri, 19 Mar 2010 17:10:26 +0100

Inherited mutations in tumor suppressor genes cause an increased risk of developing familial cancer syndromes. Many of these familial tumor suppressor genes are also frequently mutated in somatic cancers. The … [Read more] (Source: Editors' Choice)

Science in fiction and fact, John Burnside on Waking Up In Toytown

Guardian Unlimited Science — Fri, 19 Mar 2010 16:56:11 +0100

Two dispatches from the far frontiers of science send our panellists into orbit around such issues as "how many years will it be before we all carry our personal genomes around with us, alongside our mobiles and our wallets?" and "why hasn't ET phoned earth yet?"We hear astrophysicist Paul Davies's views on what the discovery of extra-terrestrial life would do to the religions of the world. And we consult a new book by Barack Obama's medical supremo, Francis Collins, to discover whether genomic medicine will be the saving of us, or our damnation.We also interview the poet and memoirist John Burnside about the problems that plagued his early adulthood, from alcoholism to the neurological condition of apophenia – the experience of perceiving patterns and connections in random objects.Readi...

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Science in fiction and fact

Guardian Unlimited Science — Fri, 19 Mar 2010 16:56:11 +0100

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK

AJP: Gastrointestinal and Liver Physiology — Fri, 19 Mar 2010 16:55:08 +0100

Progastrin and insulin-like growth factors (IGFs) stimulate hyperproliferation of intestinal epithelial cells (IECs) via endocrine/paracrine routes; hyperproliferation is a known risk factor for colon carcinogenesis. In the present study, inhibitory potency of curcumin in the presence or absence of progastrin and/or IGF-II was examined. Progastrin and IGF-II significantly increased proliferation of an immortalized IEC cell line, IEC-18, whereas curcumin decreased the proliferation in a dose-dependent manner. IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and reversed proapoptotic effects of curcumin by >80%; progastrin was relatively ineffective toward reversing proapoptotic effects of curcumin. IEC-18 clones were generated to ...

Lapatinib Minimally Effective for Non-Small-Cell Lung Cancer

Medscape Medical News Headlines — Fri, 19 Mar 2010 16:22:38 +0100

Although well tolerated, lapatinib is minimally effective as monotherapy for advanced or metastatic non-small-cell lung cancer (NSCLC), according to a report in the March 15th Clinical Cancer Research. Reuters Health Information (Source: Medscape Medical News Headlines)

Tell Us What You Think About the Health Care Package

Kidney Cancer Association — Fri, 19 Mar 2010 16:19:18 +0100

House Democrats have posted online the package of changes they want to make to the Senate-approved health care reform bill. Share your comments on the bill.03/21/2010 (Source: Kidney Cancer Association)

A world of procedures and worries: experience of children with a Port-a-Cath

Acta Paulista de Enfermagem — Fri, 19 Mar 2010 15:55:04 +0100

OBJETIVOS: Compreender como é para a criança com câncer a vivência de ser portadora de Port-a-Cath a partir de suas manifestações numa sessão de Brinquedo Terapêutico Dramático e propiciar a ela um meio de alívio. MÉTODOS: Estudo descritivo qualitativo realizado com seis crianças escolares e uma adolescente, cujos dados foram coletados numa sessão de Brinquedo Terapêutico Dramático e submetidos à análise qualitativa de conteúdo. RESULTADOS: Permitiram compreender que os procedimentos intrusivos geram ansiedade, preocupação, medo e dor às crianças, assim como que elas reconhecem a importância dos procedimentos, dos medicamentos, da realização dos exames físico e laboratoriais para o tratamento; reconhecem as vantagens da utilização do Port-a-Cath, mas que sua uti...

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The effects of Chinese calligraphy handwriting and relaxation training in Chinese Nasopharyngeal Carcinoma patients: A randomized controlled trial

International Journal of Nursing Studies — Fri, 19 Mar 2010 15:54:44 +0100

Conclusions: Similar to the effects of relaxation training, calligraphy demonstrated a gradually build-up physiological slow-down, and associated with heightened concentration and improved mood disturbance. Calligraphy offered a promising approach to improved health in cancer patients. (Source: International Journal of Nursing Studies)

Arnault Tzanck, MD (1886-1954)

Transfusion Medicine Reviews — Fri, 19 Mar 2010 15:31:46 +0100

Arnault Tzanck's name is attached to an apparatus he invented that was widely used for transfusing blood in France between the wars, as well a simple test he devised using the microscopic analysis of scrapings from skin cancer lesions, different ganglia, and some forms of dermatitis especially pemphigus. The Tzanck smear is still widely used as a test for herpes, among other diseases. He also experimented with different methods of preserving blood and blood substitutes. Tzanck's most lasting contribution was in the organization of blood transfusion in France that eventually resulted in the creation of the Centre National de Transfusion Sanguine (National Blood Transfusion Center), which was established in 1949 with Tzanck as its first director. In the process, Tzanck educated a whole gener...

TAPE- Clinical Trials and Translational Research Advisory Committee

Videocast - All Events — Fri, 19 Mar 2010 15:25:00 +0100

Presented by: Coordinating Center for Clinical Trials, National Cancer InstituteCategory: Advisory BoardsAired date: 03/10/2010 (Source: Videocast - All Events)

Disease relapse after segmental resection and free flap reconstruction for mandibular osteoradionecrosis

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:37 +0100

Conclusion: This present study confirms that microvascular free flaps are reliable for treatment of advanced mandibular ORN. Nevertheless, there remains a 55 percent incidence of wound-healing complications. The lack of objective clinical criteria to judge the appropriate amount of mandible resection in patients with ORN remains an unresolved issue that resulted in the development of recurrent ORN in 25 percent of patients. Further investigations are needed to better understand the pathophysiology of ORN to prevent postoperative wound complications and disease recurrence. (Source: Otolaryngology - Head and Neck Surgery)

Neck restaging with sentinel node biopsy in T1-T2N0 oral and oropharyngeal cancer: Why and how?

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:37 +0100

Conclusion: The SN biopsy technique appeared to be the best staging method in cN0 patients and provided evidence that routinely undiagnosed lymph node invasion may have clinical significance. (Source: Otolaryngology - Head and Neck Surgery)

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Bax, cytochrome c, and caspase-8 staining in parotid cancer patients: Markers of susceptibility in radiotherapy?

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:37 +0100

Conclusion: Bax, cytochrome c, and caspase-8 protein expression failed to independently predict survival in parotid cancer patients. However, patients with bax (−) or caspase-8 (−) tumors should be considered as candidates for adjuvant radiotherapy in order to achieve better local disease control. (Source: Otolaryngology - Head and Neck Surgery)

Complications of esophagoscopy in an academic training program

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:34 +0100

Conclusion: The 2.6 percent esophageal perforation rate observed in this study is higher than that typically reported for rigid esophagoscopy. When performed as part of routine panendoscopy, no synchronous esophageal tumors were found, questioning the value of esophagoscopy in this setting. All perforations occurred in patients with a history of head and neck cancer and were associated with the level of the surgeon's experience in performing rigid endoscopy. (Source: Otolaryngology - Head and Neck Surgery)

Metastases in odontogenic cysts: literature review and case presentation

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Fri, 19 Mar 2010 15:22:23 +0100

Malignant tumors in the oral cavity are relatively rare. About 5% of all malignant growths in the body are localized in the oral cavity. The vast majority of oral malignancies are primary tumors with squamous cell carcinoma being the most frequent and sarcomas occurring very seldom. Secondary tumors caused by hematogenous spread arising from a tumor localized elsewhere in the body are extremely rare. About 1% of all oral cancers are metastases to the jawbones and the surrounding soft tissues. Metastases to the jaws are mainly caused by malignant tumors of the breast, lung, kidney, bone, and colon. They occur in the late state of the disease and are regularly detected by staging examinations including scintigraphy. Even more rare are metastases into odontogenic cysts. Odontogenic cysts incl...

Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Fri, 19 Mar 2010 15:22:22 +0100

Conclusion: We identified species not previously identified in chemotherapy patients. Our results suggest a shift to a more complex oral bacterial profile in patients undergoing cancer chemotherapy. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Loss of expression of TIMP3 in clear cell renal cell carcinoma

Kidney Cancer Association — Fri, 19 Mar 2010 15:17:41 +0100

In clear cell renal cell carcinoma (CCRCC), vascular endothelial growth factor (VEGF) represents the central positive mediator of tumour angiogenesis while VEGF receptor (VEGFR) is the primary target of anti-angiogenic therapies. TIMP3 is a physiological VEGFR-2 antagonist and thus could be considered as an anti-angiogenic factor. We therefore determined the status of this physiological inhibitor in CCRCC.03/21/2010 (Source: Kidney Cancer Association)

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Glowing Dye Improves Cancer Removal in Kidney

Kidney Cancer Association — Fri, 19 Mar 2010 15:16:18 +0100

A new way to provide clear images of cancerous tumors in the kidney during surgery promises to help physicians preserve as much kidney function as possible while still removing all the malignant tissue a significant advance as doctors discover that saving as much healthy kidney tissue as possible is crucial for the future health of cancer patients.03/17/2010 (Source: Kidney Cancer Association)

Noscapine for Prostate Cancer

Disabled World — Fri, 19 Mar 2010 15:14:49 +0100

Study shows further benefits of noscapine for prostate cancer - New research has revealed a major breakthrough in the use of cough medicine ingredient noscapine as a prophylactic treatment for prostate cancer. (Source: Disabled World)

Laparoscopic Radical Nephrectomy For Renal Cell Carcinoma

Kidney Cancer Association — Fri, 19 Mar 2010 15:13:14 +0100

In 73 patients with kidney cancer undergoing laparoscopic radical nephrectomy and followed for mean 11.2 years, cancer-specific and overall survival were 78% and 35%, respectively. Cancer recurred in 11% of patients; in 7%, the recurrence occurred late at 8-10 years after surgery.03/21/2010 (Source: Kidney Cancer Association)

Genetics Add Little to Breast Cancer Risk Prediction (CME/CE)

MedPage Today Hematology/Oncology — Fri, 19 Mar 2010 15:13:06 +0100

The addition of genetic information only modestly improved breast cancer risk assessment in an analysis of 5,600 cases. (Source: MedPage Today Hematology/Oncology)

New Agents for Metastatic Colorectal Cancer Increase Survival, Cost (CME/CE)

MedPage Today Gastroenterology — Fri, 19 Mar 2010 15:13:04 +0100

The newer agents used against metastatic colorectal cancer are associated with increased survival, and although the costs are substantial they fall within the range of most willingness-to-pay estimates, researchers said. (Source: MedPage Today Gastroenterology)

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BES: 'Mild' Parathyroid Disease Poses Mortality Risk (CME/CE)

MedPage Today Endocrinology — Fri, 19 Mar 2010 15:13:03 +0100

MANCHESTER, England (MedPage Today) -- Patients with "mild" hyperparathyroidism die from cardiovascular disease and cancer at more than twice the rate of other people, suggesting that current practices of merely watching such patients may need revision, a researcher said here. (Source: MedPage Today Endocrinology)

The Psychosocial Impact of Completing Childhood Cancer Treatment: A Systematic Review of the Literature

Journal of Pediatric Psychology — Fri, 19 Mar 2010 15:11:47 +0100

Conclusions Completing treatment can be a psychologically complex time for children as they wait to make the transition from "cancer patient" to long-term "cancer survivor." Further high-quality research targeting the needs of these children is warranted. (Source: Journal of Pediatric Psychology)

Roche Increased Avastin Sales Efforts; Doubles US Force

Kidney Cancer Association — Fri, 19 Mar 2010 15:11:40 +0100

The moves come after Roche paid $46.8 billion to takeover Genentech Inc., which developed the drug. Avastin was Roche's biggest seller in 2009 with sales of about $5.9 billion, making up about 13% of its total, but it has faced multiple setbacks in its development since the deal closed about a year ago.03/20/2010 (Source: Kidney Cancer Association)

UK cancer death risk is 70% higher in men

Kidney Cancer Association — Fri, 19 Mar 2010 15:10:02 +0100

Unhealthy lifestyles and a 'stiff upper lip' make men up to 70 per cent more likely to die from cancer than women, doctors have warned.03/20/2010 (Source: Kidney Cancer Association)

Shutting out soft tissue cancers in the cold

ScienceDaily Headlines — Fri, 19 Mar 2010 15:00:00 +0100

Cryotherapy, an interventional radiology treatment to freeze cancer tumors, may become the treatment of the future for cancer that has metastasized in soft tissues (such as ovarian cancer) and in bone tumors. Such patients are often not candidates for surgery and would benefit from minimally invasive treatment, say researchers. (Source: ScienceDaily Headlines)

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Coloproctology

Springer Medicine titles — Fri, 19 Mar 2010 14:19:18 +0100

series:Springer Specialist Surgery SeriesColoproctology is an essential aid for those who need a practical understanding of particularly complex procedures in this specialty.Edited and authored by outstanding surgeons in their fields, this book brings the reader expertise in surgery and management across the various conditions encountered in colorproctology, from Sigmoid Diverticulitis to colorectal cancer. Didactic in its approach, ... (Source: Springer Medicine titles)

Lilly Discloses Full List Of Drugs In Conn. Theft

Drugs.com - Pharma News — Fri, 19 Mar 2010 14:05:22 +0100

From Associated Press (March 18, 2010) INDIANAPOLIS -- Drug maker Eli Lilly and Co. said that thieves who broke into one of its warehouses over the weekend made off with drugs including the cancer treatments Alimta and Gemzar, and the blood thinner... (Source: Drugs.com - Pharma News)

N.L. colorectal cancer screening targets those 50 to 74

CTV Health — Fri, 19 Mar 2010 14:05:07 +0100

The Newfoundland and Labrador government is bringing in a new colorectal cancer screening program. (Source: CTV Health)

Sustained Inflammation Due to Nuclear Factor-Kappa B Activation in Irradiated Human Arteries

Journal of the American College of Cardiology — Fri, 19 Mar 2010 14:00:31 +0100

Conclusions: In the present study, we found sustained inflammation due to NF-κB activation in human radiated arteries. The results are supported by previous in vitro findings suggesting that deoxyribonucleic acid injury, after radiation, activates NF-κB. We also suggest that HOXA9 might be involved in the regulation of NF-κB activation. The observed sustained inflammatory response can explain cardiovascular disease years after radiation. (Source: Journal of the American College of Cardiology)