MedWorm: Carcinosarcoma

Squamous cell carcinoma and osteosarcoma arising from a dermoid cyst-a case report and review of literature.

International Journal of Clinical and Experimental Pathology — Sun, 14 Mar 2010 20:24:03 +0100

Authors: Allam-Nandyala P, Bui MM, Caracciolo JT, Hakam A A rare case of multiple malignant tumors (poorly differentiated squamous cell carcinoma and high grade osteosarcoma) arising in an ovarian dermoid cyst of a 55 year old female is reported. To the best of our knowledge, this is the first well documented example of such an unusual combination of tumors arising in a dermoid cyst. The osteosarcoma and squamous cell carcinoma appear to arise in the background of benign teratomatous environment of a dermoid cyst rather than from "pure" mixed mesodermal tumors of the ovary. The tumors did not appear to have well demarcated boundaries with a junction or close intermingling of both cell types, features less favorable for collision tumor or carcinosarcoma. Despite extensive surgery with n...

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A case of rapidly growing pulmonary carcinosarcoma

International Journal of Clinical Oncology — Wed, 10 Mar 2010 16:13:28 +0100

We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A 65-year-old man was referred for further examination of a lung tumor after a routine chest X-ray (CXR) showed a tumor shadow in the right upper lung zone. Chest computed tomography (CT) found a 2.0 cm pulmonary mass with suspected chest wall invasion in the right upper lobe, although cytological evidence of malignancy could not be obtained despite repeated preoperative bronchoscopy. The tumor grew rapidly, indicating the possibility of lung cancer. A right upper lo...

Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells

Journal of Clinical Pathology — Thu, 04 Mar 2010 15:42:50 +0100

Carcinosarcoma of the pancreas is extremely rare and its histogenesis is still unclear. This is a report on a 64-year-old female patient with an intraductal carcinosarcoma arising from intraductal papillary-mucinous carcinoma (IPMC) in the pancreas tail. The carcinosarcoma grew as a polypoid mass within the main pancreatic duct. Histologically, the tumour consisted of adenocarcinoma covering the luminal surface of the lesion with minimal stromal invasion, and osteosarcoma occupying the stroma. Immunohistochemical and gene mutation analyses revealed that both the carcinomatous and sarcomatous tumour cells of the carcinosarcoma, as well as the IPMC cells, expressed TP53 and had identical mutations in KRAS and TP53 genes, indicating that these two neoplastic components of the carcinosarcoma s...

Novel epitheliomesenchymal biphasic stomach tumour (gastroblastoma) in a 9-year-old: morphological, usltrastructural and immunohistochemical findings

Journal of Clinical Pathology — Thu, 04 Mar 2010 15:42:50 +0100

This report describes a probable fourth case of this unique type of neoplasm. The present case arose in the gastric antrum of a 9-year-old boy. While similarities were evident with the other cases, there were some differences. The epithelial component was more predominant and showed more mature morphology. Immunohistochemically, the epithelial component showed immunolabelling for c-KIT and CD56. The mesenchymal component was only focally positive for CD10. Ultrastructually, desmosomes and microvilli were found supporting a truly epithelial lesion. (Source: Journal of Clinical Pathology)

The dynamics of reactive oxygen species in photodynamic therapy with tetra sulfophenyl-porphyrin.

Acta Physiologica Hungarica — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Clichici S, Filip A, Daicoviciu D, Ion RM, Mocan T, Tatomir C, Rogojan L, Olteanu D, Muresan A Photodynamic therapy (PDT) is a promising therapy especially in skin cancer, using the systemic administration of a photosensitizer (PS), followed by the local irradiation of the tumor with visible light. The antitumor effects of PDT are determined especially by the generation of cytotoxic reactive oxygen species (ROS). The 5,10,15,20-tetrasulfophenyl-porphyrin (TSPP) is a synthetic photosensitizer, which proved its efficiency in in vitro studies. Our study evaluates the effects of PDT with TSPP upon the tumor levels of ROS and upon the metalloproteinases 2 (MMP2) activities on Wistar male rats bearing 256 Walker carcinosarcoma in correlation with the accumulation of PS in the tumor ...

Hepatocellular Carcinoma and Hepatic Adenocarcinosarcoma in a Patient with Hepatitis B Virus-Related Cirrhosis

Seminars in Liver Disease — Sat, 20 Feb 2010 14:23:38 +0100

Semin Liver Dis 2010; 30: 107-112DOI: 10.1055/s-0030-1247137ABSTRACTThe authors present the case of a 48-year-old man with hepatitis B cirrhosis, who developed two primary malignant liver tumors that were morphologically distinct from each other. The first tumor was a hepatocellular carcinoma and the second tumor, detected 17 months later was a hepatic carcinosarcoma with cholangiocarcinomatous and sarcomatous components, without any hepatocellular carcinoma component. Clonality studies using microsatellite-based loss of heterozygosity (LOH) demonstrated different LOH patterns existed between the hepatocellular carcinoma and the hepatic carcinosarcoma, indicative of different clonal origins. The authors discuss the histogenesis, histopathologic diagnosis, and clinical behavior of hepatic c...

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Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma.

Acta Cirurgica Brasileira — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSION: The Tacrolimus-treated group developed a more aggressive tumor and a drug-related nephrotoxic effect. PMID: 20126896 [PubMed - in process] (Source: Acta Cirurgica Brasileira)

Primary cutaneous carcinosarcoma: Dermoscopic and immunohistochemical features.

The Australasian Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Upjohn E, Braue A, Ryan A A 73-year-old man presented a 9-month history of an enlarging nodule on his right temple. Dermoscopy revealed a non-pigmented lesion with ulceration, fibrosis and pale globules. An excisional biopsy was carried out and histology showed a biphasic tumour with a basal cell carcinoma like epithelial component and a dermal undifferentiated sarcoma, with pleomorphic spindle cells and numerous osteoclast-like giant cells. Based on immunohistochemistry findings, a diagnosis of primary cutaneous carcinosarcoma was made and the patient underwent wide local excision. PMID: 20148837 [PubMed - in process] (Source: The Australasian Journal of Dermatology)

Long-term Recurrence-free Survival in a Patient with Primary Hepatic Carcinosarcoma: Case Report with a Literature Review

Japanese Journal of Clinical Oncology — Fri, 29 Jan 2010 11:44:42 +0100

A 72-year-old man was found to have a 40 mm mass in liver segment VIII during follow-up abdominal ultrasonography for type C viral hepatitis. Abdominal ultrasound showed a well-defined mass containing a cystic component, and computed tomographic hepatic arteriography showed heterogeneous enhancement except for cystic necrosis. Under a pre-operative diagnosis of atypical hepatocellular carcinoma (HCC), partial resection of liver segment VIII was performed. The encapsulated tumor consisted of a peripheral solid component with a central necrotic area. Histologically, the solid component had a two-layer structure, an HCC component in the external area and a sarcomatous component with neoplastic osteoid formation in the internal area, showing histological transition. Immunohistochemically, the ...

Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination

Diagnostic Pathology — Fri, 29 Jan 2010 00:00:00 +0100

We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient. (Source: Diagnostic Pathology)

[Uterine sarcomas... or uterine carcinosarcomas?]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Thu, 14 Jan 2010 00:00:00 +0100

Authors: Leung F, Terzibachian JJ PMID: 20079975 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

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The Role of Pelvic and/or Para-Aortic Lymphadenectomy in Surgical Management of Apparently Early Carcinosarcoma of Uterus

Annals of Surgical Oncology — Wed, 18 Nov 2009 09:27:37 +0100

Conclusions Pelvic and para-aortic lymphadenectomy should be performed in patients with apparently early carcinosarcoma of the uterus, especially in those with myometrial invasion >1/2 or LVSI. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-009-0833-6Authors Jeong-Yeol Park, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, College of Medicine Seoul KoreaDae-Yeon Kim, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, College of Medicine Seoul KoreaJong-Hyeok Kim, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, College of Medicine Seoul KoreaYong-Man Kim, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, C...

How to deal with prognostic factors and radiotherapy results in uterine neoplasms with a sarcomatous component?

Clinical and Translational Oncology — Wed, 18 Nov 2009 04:59:10 +0100

Conclusions Uterine tumours with a sarcomatous component have a poor outcome in spite of treatment in comparison to endometrial carcinoma, probably due to the higher frequency of adverse prognostic factors. In early stages tumour size was the most determining factor for OS, DFS, LRFS and DMFS. Radiotherapy significantly improved these survivals in advanced cases. Content Type Journal ArticleCategory Research ArticlesDOI 10.1007/s12094-009-0424-9Authors Ángeles Rovirosa, Hospital Clínic i Universitari Radiation Oncology Department ICMHO, IDIBAPS C/Villarroel, 170 ES-08036 Barcelona SpainCarlos Ascaso, IDBAPS, Hospital Clínic i Universitari Biostatistics Unit Barcelona SpainJaume Ordi, Hospital Clínic i Universitari Pathology Department Barcelona SpainMeritxell Aren...

Scientists Release New Data On Endometrial Cancer Therapy

Cancercompass News: Other Cancer — Tue, 17 Nov 2009 00:00:00 +0100

Current study results from the report, 'A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma,' have been published. According to a study from the United Kingdom, Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma. (Source: Cancercompass News: Other Cancer)

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma

Annals of Oncology — Tue, 27 Oct 2009 20:01:10 +0100

Conclusion: This regimen is generally well tolerated with encouraging efficacy. (Source: Annals of Oncology)

Surgical outcome of carcinosarcoma of the gall bladder: A review.

World Journal of Gastroenterology : WJG — Tue, 20 Oct 2009 23:00:00 +0100

Authors: Okabayashi T, Sun ZL, Montgomey RA, Hanazaki K Carcinosarcoma, which comprises less than one percent of all gall bladder neoplasms, is characterized by the presence of variable proportions of carcinomatous and sarcomatous elements. Recently, several reports have described patients suffering from carcinosarcoma of the gall bladder. However, there are no large studies regarding the clinicopathologic features, therapeutic management, and surgical outcome of this disease because the number of patients who undergo resection of gall bladder carcinosarcoma at a single institution is limited. A Medline search was performed using the keywords 'gall bladder' and 'carcinosarcoma'. Additional articles were obtained from references within the papers identified by the Medline search. Optima...

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Pulmonary carcinosarcoma masquerading as a cryptic disseminated malignancy.

Indian Journal of Pathology and Microbiology — Wed, 30 Sep 2009 23:00:00 +0100

We report a case which presented with unusual clinical features and proved cryptic until death. At autopsy, it was a stage IV lung malignancy and histopathology revealed a carcinosarcoma comprising an adenocarcinoma and an osteosarcoma with metastasis to the heart, lymph nodes, and both adrenals. To our knowledge, this is the first case of this subtype with metastasis to the heart. The present case had an unusual clinical presentation and its elusive nature towards diagnosis despite dissemination is noteworthy and unique in the literature. PMID: 19805960 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Hepatic carcinosarcoma demonstrated by Ga-67 scintigraphy

Annals of Nuclear Medicine — Tue, 29 Sep 2009 03:59:26 +0100

Abstract A case of a primary hepatic carcinosarcoma, a very uncommon liver tumor in adults, demonstrated by Ga-67 scintigraphy, was reported. The liver image showed a lesion of low activity in the left lobe of the liver, whereas the Ga-67 image showed a moderate accumulation in the lesion detected by the liver scan and further indicated a high accumulation extending downwards from the hepatic lesion. An autopsy revealed that the huge abdominal tumor was composed of hepatocellular carcinoma and malignant mesenchymoma in the left hepatic lobe and in the lower part of the tumor, respectively. The Ga-67 image demonstrated these two different histological components of the tumor. Content Type Journal ArticleCategory Case ReportDOI 10.1007/BF03164592Authors Seishi Jinnouchi,...

Carcinosarcoma of the duodenum: Report of a case

Surgery Today — Tue, 29 Sep 2009 01:06:53 +0100

This report describes a case of carcinosarcoma of the duodenum. Carcinosarcoma of the duodenum is a very rare tumor. A 72-year-old man was referred to the hospital because of appetite loss. Endoscopy demonstrated an irregularly depressed lesion (type 3) in the descending portion of the duodenum opposite to the ampulla of Vater. Computed tomography showed a thickened duodenal wall and swelling of the abdominal para-aortic lymph nodes. A biopsy specimen revealed a well-differentiated adenocarcinoma. A diagnosis of duodenal carcinoma was made (cT3, cN1, cM1, cStage IV according to the TNM classification). A subtotal stomach-preserving pancreatoduodenectomy and a lymph node resection were performed. On microscopic examination, adenocarcinoma cells and spindle type sarcoma cells were obse...

Carcinosarcoma of the Ovary: A Review.

Obstetrical & Gynecological Survey — Thu, 24 Sep 2009 17:00:14 +0100

Page: 673DOI: 10.1097/OGX.0b013e3181b8aff3Authors: Cantrell, Leigh A. MD, MSPH *; Van Le, Linda MD + (Source: Obstetrical & Gynecological Survey)

Carcinosarcoma of the breast: report of a case and review of the literature

Gynecological Surgery — Wed, 16 Sep 2009 18:51:58 +0100

We present a female patient with breast CS. Relevant literature is briefly reviewed. A 65-year-old-woman was admitted for the management of a palpable mass of the left breast. Mammography depicted a high-density mass with marginal irregularity and pleomorphic calcification. Subsequent excisional biopsy revealed a biphasic metaplastic breast carcinoma, and the patient underwent a left-modified radical mastectomy. The final histopathologic diagnosis was defined as a metaplastic breast carcinoma of CS type, with a squamous cell epithelial component of intermediate and mainly low-grade differentiation. Recent case series describe CS as an uncommon lesion demonstrating an intimate admixture of adenocarcinoma and sarcoma. Current data represent further evidence of the dedifferentiation the...

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Therapeutic effectiveness of chemoradiotherapy for carcinosarcoma of the esophagus: two case reports and a review of the literature

Esophagus — Tue, 15 Sep 2009 21:44:48 +0100

We report two patients with carcinosarcoma of the esophagus who received neoadjuvant chemoradiotherapy and underwent curative resection. Patient 1 was a 50-year-old man with a type 2 lesion in the upper thoracic esophagus; clinical stage was T3 or partial T4N1M0. After chemoradiotherapy the tumor and the lymph nodes become smaller, and subtotal esophagectomy was performed. Patient 2 was a 66-year-old man with a protruding lesion in the lower thoracic esophagus. Preoperative chemoradiotherapy was administered, and he had a partial response. However, surgery was postponed because of pneumonia; 11 months later, tumor enlargement was confirmed and we then performed subtotal esophagectomy. The therapeutic role and effectiveness of both chemotherapy and radiotherapy remain unclear. We rev...

The Role of Adjuvant Radiation in Uterine Sarcomas

International Journal of Radiation Oncology * Biology * Physics — Mon, 24 Aug 2009 00:00:00 +0100

Conclusion: In the largest retrospective analysis of uterine sarcoma published thus far, AR conferred a 53% reduction in the risk of LRF at 5 years. Use of AR may have broader indications than what are currently accepted in clinical practice. (Source: International Journal of Radiation Oncology * Biology * Physics)

An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: Histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Pathology, Research and Practice — Wed, 05 Aug 2009 23:00:00 +0100

We describe the case of a 62-year-old female with an intracapsular ca ex PA of the buccal mucosa with subsequent metastases to the lung. The metastatic deposits resembled benign PA with no histological evidence of malignancy. This pattern of spread is described with mPA, an entity that caused controversy in the past regarding its exact classification as a benign or malignant tumor. The possibility that ca ex PA originates from a mPA, with intracapsular ca ex PA representing an intermediate lesion in a histological continuum, is discussed. PMID: 19665316 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

Endoscopic polypectomy: a promising therapeutic choice for esophageal carcinosarcoma.

World Journal of Gastroenterology : WJG — Mon, 20 Jul 2009 07:22:07 +0100

Authors: Ji F, Xu YM, Xu CF Esophageal carcinosarcoma is a rare malignant tumor composing of both carcinomatous and sarcomatous elements. Endoscopic therapy is less invasive and may represent an alternative to esophagectomy for superficial esophageal carcinosarcoma. Here, we report a 61-year-old male who was diagnosed as esophageal carcinosarcoma and underwent endoscopic polypectomy with well tolerance and favorable prognosis. We also present a brief review of the literature. PMID: 19610152 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Carcinosarcoma of the Prostate Replacing the Entire Lower Genitourinary Tract

Urology — Tue, 07 Jul 2009 23:00:00 +0100

Less than 100 cases of prostate carcinosarcoma have been described in published studies. Most of these cases describe symptoms due to bladder outlet obstruction that typically results in transurethral resection of the prostate. Our patient presented with tenesmus and stranguria due to prostate carcinosarcoma that developed years after being treated with external radiation and androgen deprivation for prostate adenocarcinoma. Because of the patient's escalating symptoms, a pelvic exenteration with creation of urinary and fecal diversions was performed. Despite the dismal survival associated with prostate carcinosarcoma, palliative surgical extirpation can be successful in patients with debilitating pain. (Source: Urology)

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Spindle cell sarcoma of larynx

Indian Journal of Otolaryngology and Head & Neck Surgery — Tue, 07 Jul 2009 15:21:05 +0100

Abstract Spindle cell carcinoma of larynx is rare tumors constituting only 0.6% of laryngeal neoplasm with predominance in elderly males (average 63 yrs). These tumors were described under various names: pseudosarcoma, Carcinosarcoma, fibromyxosarcoma, mixed sarcoma, polypoidal sarcoma. Immunohistochemistry and electron microscopy suggest that spindle cell carcinoma are true neoplasm and spindle cells are part of the neoplasm and not benign reactive fibroblast. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF03050852Authors Sunil Samdhani, SMS Medical College and Hospital Department of ENT JaipurAnita Choudhary, SMS Medical College and Hospital Department of ENT JaipurVibhuti Ranjan Mahanta, SMS Medical College and Hospital Department of ENT JaipurS...

Establishment and characterization of the NEYS cell line derived from carcinosarcoma of human ovary with special reference to the susceptibility test of anticancer drugs

Human Cell — Wed, 24 Jun 2009 23:00:00 +0100

A cell line designated as NEYS was established from ovarian carcinosarcoma (stage IIIc) of a 56-year-old Japanese woman. The extirpated original tumor was carried in growth medium at 0 °C to the culture room. The primary culture was done on 20 August 2003. The cell line was composed of angular adhesive cells and showed neoplastic and pleomorphic features, such as bizarre aggregation of chromatin granules, an irregular thickening nuclear membrane and multiple large nucleoli. They grew as multi-layered cultures without contact inhibition. The cells proliferated moderately, and population doubling time was about 56 h. The chromosome number showed an underdiploidy of aneuploidy. The modal chromosome numbers were 37 (36%) and 38 (26%). The cultures produced carcinoembryonic antigen (27.4 ng/mL...

Rapid-growth carcinosarcoma of the esophagus arising from 0-IIc squamous cell carcinoma after definitive chemoradiotherapy: a case report

Esophagus — Wed, 17 Jun 2009 09:43:06 +0100

Abstract A case of carcinosarcoma arising from the area of intraepithelial spread of relapsed esophageal squamous cell carcinoma (SCC) after definitive chemoradiotherapy (CRT) is reported herein. A 71-year-old man was referred to our hospital because of a superficial esophageal carcinoma. Definitive CRT was performed because the patient refused surgical treatment. Complete response was recognized after CRT, but tumor relapse was diagnosed 3 months later. The relapsed tumor initially revealed a minimal depression with a small white nodule. This nodule developed to a sessile elevated mass after 1 month and finally to a polypoid tumor 3.2 × 2.3 × 1.5 cm in size within 125 days. A subtotal esophagectomy with two-field lymph node dissection was performed. Histologically, the ...

Malignant neoplasms of the uterus following radiation therapy for cervical carcinoma: a clinical study of 47 cases

The Chinese-German Journal of Clinical Oncology — Mon, 15 Jun 2009 06:50:13 +0100

Conclusion The main uterine neoplasms development after radiation therapy for cervical carcinoma is endometrial carcinomas, of which there is a preponderance of high-risk histological subtypes and a poor prognosis. Most of the uterine sarcomas occurred following radiation therapy for cervical carcinoma are carcinosarcomas and the prognosis is very poor. Content Type Journal ArticleDOI 10.1007/s10330-009-0074-yAuthors Shaokang Ma, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical College Beijing 100021 ChinaLingying Wu, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical College Beijing 100021 China Journal The Chinese-German Journal of Clinical On...

Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism

Cancer Chemotherapy and Pharmacology — Tue, 09 Jun 2009 12:38:17 +0100

Conclusion These results confirm the antitumor effects of celecoxib in W256 cancer model, contributing to elucidating its antitumoral mechanism and corroborating scientific literature about its effect on other types of cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1031-8Authors Amanda Leite Bastos-Pereira, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilDaiana Lugarini, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilAdriana de Oliveira-Christoff, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilThiago Vinicius Ávila, Federal University of Paraná, Bio...

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Bilateral breast metastasis of lung carcinosarcoma

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Thu, 04 Jun 2009 23:00:00 +0100

A 74-year-old woman presented symptoms of coughing with bloody sputum. A mass obliterating the bronchial segment of the superior lobe of the right lung was defined by thoracic computed tomography (CT) and treated by superior lobectomy. Grossly, a firm mass (7.5cm×6cm) with a heterogeneous cut surface from tan-grey to red was found. The tumor showed a diffuse proliferation of spindle-ovoid cells (vimentin+, S100 focally+) and an irregular glandular architecture (pancytokeratin: AE1&AE3+, EMA+). Desmin, smooth muscle actin (SMA), CD34, surfactant apoprotein A and TTF-1 were negative. The peribronchial lymph nodes were negative for metastasis. Fifteen months later, the patient presented with palpable nodules in both breasts. These nodules were defined as well-circumscribed and hypoechoic on ...

Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.

The American Journal of Pathology — Sun, 31 May 2009 23:00:00 +0100

Authors: Saegusa M, Hashimura M, Kuwata T, Okayasu I Uterine carcinosarcomas (UCSs) are considered to represent true examples of the epithelial-mesenchymal transition. Akt plays a key role in the induction of epithelial-mesenchymal transition, but little is known about its involvement in tumorigenesis. Here we examined the functional roles of the Akt/beta-catenin pathway in UCSs. In clinical samples, phospho-Akt (pAkt) expression was found to be significantly increased in mesenchymal compared with epithelial components, exhibiting both positive and negative correlations with nuclear beta-catenin and E-cadherin, respectively. Expression levels of the transcription factor Slug were also significantly up-regulated in the mesenchymal components and strongly correlated with both pAkt and nu...

Carcinosarcoma in the pouch of Douglas

Archives of Gynecology and Obstetrics — Sun, 31 May 2009 08:11:47 +0100

Conclusion The present case shows that carcinosarcoma can occur in the pouch of douglas. It may arise from misplaced Mullerian duct remnants in the pouch of douglas. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1132-yAuthors Tadashi Terada, Shizuoka City Shimizu Hospital Department of Pathology Miyakami 1231 Shimizu-Ku Shizuoka 424-8636 Japan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection?

European Journal of Cancer Care — Thu, 28 May 2009 04:00:00 +0100

We report a carcinosarcoma of the pancreas with liver metastasis combined with gastrointestinal stromal tumour (GIST) of the stomach in a 72-year-old woman who presented with right upper quadrant pain, nausea and vomiting. A radical resection including pancreaticoduodenectomy, left hepatic lobe resection and local resection of the gastric mass was performed. The tumour in the head of pancreas was found to be grossly yellow-white, and it infiltrated the common bile duct and duodenum; the mass of the liver metastasis is solitary. Pathologic examination showed two components separated from each other: one component was a conventional infiltrating pancreatic ductal adenocarcinoma, and the other component showed sarcomatous growth pattern composed of pleomorphic spindle cells. The neoplasm of t...

Clinical manifestation of esophageal carcinosarcoma: a Taiwan experience

Diseases of the Esophagus — Fri, 15 May 2009 04:00:00 +0100

This study aimed to investigate its clinicopathologic features and endoscopic characteristics. The data of patients diagnosed to have esophageal carcinosarcoma pathologically in the past 30 years (January 1976[ndash]December 2007) were reviewed. Of 3318 cases of esophageal malignancy, 12 were diagnosed as esophageal carcinosarcoma, with an incidence of 0.36%. All of the cases were male with a mean age of 62.3 years. Of the 12 tumors, 8 were polypoid type, and 4 were ulcerative type. In the endoscopic ultrasonography examination, the tumors show heterogeneous hypoechoic lesions with irregular outer margins and internal multicystic components. Four patients (33.3%) had previous head and neck squamous cell carcinoma that occurred metachronously. This is the first report about the characterist...

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Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma - Report of an unusual case

Head — Wed, 13 May 2009 04:00:00 +0100

The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods.The SCC was typical, but few cells showed a spindle-shaped pattern. The relapse tumor was a spindle-shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm-actin+, desmin+, caldesmon+, vimentin+, keratin-).The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed in the primary. A fluorescence in situ hybridization (5p) focally detected 3 chromosmomal copies, corresponding to gains on 5p in CGH of leiomyosarcoma.Leiomyosarcoma afte...

Miscellaneous Uterine Malignant Neoplasms Detected during Hysteroscopic Surgery

The Journal of Minimally Invasive Gynecology — Fri, 01 May 2009 04:00:00 +0100

Conclusion: Resectoscopic surgery in women with miscellaneous uterine malignant lesions not adversely affect 5-year survival and long-term prognosis. (Source: The Journal of Minimally Invasive Gynecology)

Recent progress: gynecologic oncology group trials in uterine corpus tumors.

Reviews on Recent Clinical Trials — Thu, 30 Apr 2009 23:00:00 +0100

This article will discuss the background and details of each of these important advances. PMID: 19463102 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)

[Tamoxifen in the adjuvant setting for breast cancer: Reflexions about the risk of uterine carcinosarcoma]

Gynecologie, Obstetrique & Fertilite — Thu, 30 Apr 2009 23:00:00 +0100

Authors: Leung F, Terzibachian JJ, Govyadovskiy A, Bourtembourg A, Maillet R, Riethmuller D A descriptive analysis of available data on reported cases of uterine carcinosarcomas associated with tamoxifen therapy is undertaken. The role of aromatase inhibitors as alternative to tamoxifen therapy in the adjuvant setting of breast cancer is discussed. The eventual implications of the presumed association of uterine carcinosarcoma and tamoxifen therapy on the choice of the therapeutic agent in the adjuvant setting of hormone-sensitive breast cancer are discussed. PMID: 19394886 [PubMed - in process] (Source: Gynecologie, Obstetrique & Fertilite)

Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma

Diagnostic Cytopathology — Thu, 16 Apr 2009 04:00:00 +0100

We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules. He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site. FNAC from the pleural lesions showed myxoid background substance with entrapped cuboidal epithelial cells with atypical nuclei, which were interpreted as mesothelial cells. These cells in contrast to the usual mesothelial cells were not arranged in sheets but rather were huddled in places and formed a pseudoacinar pattern and blended with the myxoid substance.After the diagnosis of a mesothelioma, p...

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Treatment of early uterine sarcomas: disentangling adjuvant modalities

BioMed Central — Wed, 08 Apr 2009 04:00:00 +0100

Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas and "other" sarcomas. The pathological subtype demands a tailored approach. Surgical resection is regarded as the mainstay of treatment. Total abdominal hysterectomy and bilateral salpingo-oophorectomy represents the standard treatment of uterine sarcomas. Pelvic and para-aortic lymph node dissection in carcinosarcomas is recommended, given their high incidence of lymph node metastases, and may have a role in endometrial stromal sarcomas. Adjuvant radiation therapy has historically been of little survival value, but it appears to improve loc...

Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumor

Journal of Hepato-Biliary-Pancreatic Surgery — Tue, 07 Apr 2009 05:57:56 +0100

We report a case of 78-year-old woman histopathologically diagnosed after surgery. Macroscopically, the tumor was a dark-greenish solid mass with a short stalk, filling the gallbladder cavity, and it measured 11.5 × 4.0 × 3.5 cm in diameter. Microscopically, the tumor was composed of abundant loose stroma and a glandular component. Some of the glandular cells had hyperchromatic nuclei with disturbed polarity and were positively stained by p53 (30%) and Ki-67 (30–40%). Part of the stromal component revealed hypercellularity with an irregular nucleus, mitosis (2–3 cells/10 high-power fields), and positivity for Ki-67 (20%) and p53 (50%). We diagnosed this peculiar tumor as “fibroadenoma of the gallbladder with borderline malignancy”. We present the de...

Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier.

Breast Cancer — Mon, 06 Apr 2009 23:00:00 +0100

This report exemplifies that even very uncommon breast tumor types may develop through biallelic inactivation of BRCA1 gene, that has to be considered in the genetic testing settings. PMID: 19350356 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Carcinosarcoma of the gallbladder.

Indian Journal of Pathology and Microbiology — Wed, 01 Apr 2009 04:00:00 +0100

Authors: Agarwal T, Jain M, Goel A, Visayaragavan P, Gupta RK Carcinosarcoma of the gallbladder is an uncommon neoplasm. We herein report the case of a patient with carcinosarcoma of the gallbladder, treated by simple cholecystectomy for a tumor which was confined to the gallbladder. PMID: 19332928 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases.

Indian Journal of Pathology and Microbiology — Wed, 01 Apr 2009 04:00:00 +0100

We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. PMID: 19332899 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

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Carcinosarcoma of the colon: a rare cause of colovesical fistula.

The American Surgeon — Tue, 31 Mar 2009 23:00:00 +0100

Authors: Patel DH, Dang S, Bentley FR, Julka RN, Olden KW, Aduli F Carcinosarcomas are relatively rare tumors composed of both carcinomatous and sarcomatous components. The most common sites involved by this tumor are the head and neck, respiratory tract, uterus, ovaries, and fallopian tubes. Within the gastrointestinal tract this tumor most often occurs in the esophagus, followed by the stomach. Carcinosarcomas are very aggressive tumors associated with a poor prognosis. The first case of carcinosarcoma of the colon was reported in 1986. The case reported here is the only one involving an associated colovesical fistula. PMID: 19385296 [PubMed - indexed for MEDLINE] (Source: The American Surgeon)

Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a case

Surgery Today — Thu, 12 Mar 2009 10:24:43 +0100

Abstract A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm3, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for AFP, but negative for G-CSF. This is the first report of a carcinosarcoma of the gallbl...

Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature

Archives of Gynecology and Obstetrics — Thu, 05 Mar 2009 14:59:40 +0100

Conclusion We suppose that the similar proportion of p53 overexpression in both the epithelial and mesenchymal components may be one of the findings explaining the histogenesis of this tumor by combination theory. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1017-0Authors Kyuichi Kadota, University Hospital, Kagawa University Department of Diagnostic Pathology, Faculty of Medicine 1750-1, Ikenobe Miki-cho Kagawa 761-0793 JapanReiji Haba, University Hospital, Kagawa University Department of Diagnostic Pathology, Faculty of Medicine 1750-1, Ikenobe Miki-cho Kagawa 761-0793 JapanMasashi Ishikawa, University Hospital, Kagawa University Department of Diagnostic Pathology, Faculty of Medicine 1750-1, Ikenobe Miki-cho Kagawa 761-0793 JapanYoshio Kush...

Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma.

Histopathology — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Pristauz G, Moinfar F, Chromecki T, Bader AA, Winter R, Tamussino K PMID: 19309402 [PubMed - in process] (Source: Histopathology)

Differential expression of topoisomerase II alpha protein in salivary gland carcinomas: histogenetic and prognostic implications

BMC Cancer — Fri, 27 Feb 2009 05:00:00 +0100

Background: Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase II alpha (topoII alpha), located at chromosome 17q21-22, is considered a major mediator of cell proliferation and DNA replication. The purpose of this study was to evaluate the expression of topoII in various types of salivary gland tumors and its biological significance. Methods: The protein expression of topoII alpha was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors). The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise spec...

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Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reports.

Reactions Weekly — Sun, 15 Feb 2009 12:38:35 +0100

Page: 31 (Source: Reactions Weekly)

Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reports

Reactions — Sun, 15 Feb 2009 12:14:34 +0100

(Source: Reactions)

Carcinosarcoma of the gallbladder: Report of a case

Surgery Today — Sat, 07 Feb 2009 10:16:48 +0100

This report describes a 70-year-old male patient who was diagnosed by documenting the epithelial and mesenchymal components with histopathological and immunohistochemical methods, and treated by a radical cholecystectomy. The pediculated polypoid tumor had filled the lumen, originating from the gallbladder fundus. The tumor infiltrated the surrounding connective and adipose tissue overlapping the muscular layer of its primary site, but had not perforated the serosa nor invaded the liver. The patient, who was treated only surgically, has remained healthy after 54 months of follow-up, which is the longest documented survival for this disease. This case indicates that curative treatment of a tumor confined to the gallbladder without liver or serosa invasion, or lymph node involvement, ...

Evaluation of prognostic factors and treatment outcomes in uterine carcinosarcoma.

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Fri, 06 Feb 2009 05:00:00 +0100

CONCLUSION: The poor outcome for these patients may reflect the aggressive nature of carcinosarcoma and that at the time of presentation more than 50% have extra-uterine disease, which was associated with significant poorer survival. Systemic adjuvant therapy has not been associated with significant improvement in the outcome. More studies are needed to better define the appropriate treatment for this rare cancer. PMID: 19201517 [PubMed - as supplied by publisher] (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.

American Journal of Obstetrics and Gynecology — Thu, 05 Feb 2009 05:00:00 +0100

CONCLUSION: In uterine carcinosarcoma, estrogen receptor beta expression is elevated and increases with disease progression, whereas estrogen receptor alpha and progesterone receptor are suppressed. Human epidermal growth factor receptor 2 expression is increased, whereas insulin-like growth factor receptor is lower than in normal endometrium. These data support a potential role for estrogen receptor beta in disease progression via crosstalk with human epidermal growth factor receptor 2. PMID: 19200930 [PubMed - as supplied by publisher] (Source: American Journal of Obstetrics and Gynecology)

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P63 is a helpful tool in the diagnosis of a primary cutaneous carcinosarcoma.

Journal of Cutaneous Pathology — Sun, 01 Feb 2009 05:00:00 +0100

Authors: Romanelli P, Miteva M, Schwartzfarb E, Ricotti C, Sullivan T, Abenoza P, Nadji M PMID: 19208080 [PubMed - in process] (Source: Journal of Cutaneous Pathology)

Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis.

Histopathology — Sun, 01 Feb 2009 05:00:00 +0100

Conclusions: Endometrial stromal sarcoma with extensive endometrioid glandular differentiation is rare. The presence of glands often results in diagnostic difficulty with a significant risk of misdiagnosis or delay in diagnosis. It is likely that some cases reported in the literature as aggressive endometriosis represent this entity. PMID: 19236513 [PubMed - in process] (Source: Histopathology)

A True Pulmonary Carcinosarcoma that Required Diagnostic Differentiation from a Pleomorphic Adenoma: A Case Report.

Annals of Thoracic and Cardiovascular Surgery — Sun, 01 Feb 2009 05:00:00 +0100

Authors: Yoshino N, Kubokura H, Yamauchi S, Ohaki Y, Koizumi K, Shimizu K Pulmonary carcinosarcoma is a rarely encountered tumor. We treated a patient who had an intrabronchial polypoid lesion that required a diagnostic differentiation from epithelial-mesenchymal mixed neoplasms inclusive of pleomorphic adenoma, and that was diagnosed by immunohistochemical staining to be a true carcinosarcoma. A 69-year-old man underwent left pneumonectomy in November 2000 with a diagnosis of atelectasis resulting from a tumor obstructing the left lower lobar bronchus, and also a lung abscess. The tumor was initially diagnosed as pleomorphic adenoma, since it contained both benign-looking epithelial and mesenchymal elements, but immunohistochemical staining demonstrated myoglobin-positive rhabdomyosar...

A rare case of primary extragenital retroperitoneal carcinosarcoma with review of the literature

Gynecological Surgery — Thu, 15 Jan 2009 07:50:23 +0100

Abstract Carcinosarcomas are rare, highly aggressive neoplasms that most commonly arise from the female genital tract but can unusually present in extragenital locations. To the best of our knowledge, only three cases of primary retroperitoneal, extragenital carcinosarcomas have been documented in the English literature to date. A 72-year-old woman presented with onset of abdominal pain and urinary retention. Computed tomography scan revealed a mass in the retroperitoneal space with hydronephrosis and partial obstruction of the left ureter. Lost to follow-up at that time, the patient returned 6 months later with a left leg deep vein thrombosis. On exploratory laparotomy at that time, the retroperitoneal mass was found to completely engulf the left ureter, iliac artery...

Primary Carcinosarcoma of the Spleen: Case Report of a Rare Tumor and Review of The Literature

International Journal of Surgical Pathology — Wed, 14 Jan 2009 05:00:00 +0100

Carcinosarcoma of extragenital organs is rare. In this article, a case of primary carcinosarcoma of the spleen, which presented as painful splenomegaly is reported. To the best of our knowledge, this is the second reported case of primary splenic carcinosarcoma in English literature. The pathogenesis of these tumors is incompletely understood. No specific treatment guidelines exist for these aggressive tumors, surgery being the mainstay of treatment. The prognosis remains poor regardless of the adjuvant therapy used. (Source: International Journal of Surgical Pathology)

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Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum

Familial Cancer — Thu, 08 Jan 2009 09:07:14 +0100

Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is primarily linked to colorectal and endometrial cancer, but is associated with a broad tumor spectrum. Though not formally part of the syndrome, occasional sarcomas have been reported in individuals with HNPCC. We used the national Danish HNPCC-register to identify HNPCC families in which sarcomas had been diagnosed. Fourteen sarcomas were identified in families with mutations in MSH2, MSH6, and MLH1. The median age at sarcoma diagnosis was 43 (15–74) years. Soft tissue sarcomas predominated followed by uterine sarcomas and eight histopathological subtypes were represented with recurrent diagnoses of liposarcoma, leiomyosarcoma, and carcinosarcoma. Tumor tissue from eight cases was available for analysis of...

[Uterine carcinosarcomas associated with tamoxifen therapy. Report of two cases and review of the literature.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Wed, 07 Jan 2009 05:00:00 +0100

We report two more cases of uterine carcinosarcoma occurring in two postmenopausal patients benefiting from tamoxifen therapy as adjuvant treatment of breast cancer. A review of the literature is undertaken. PMID: 19135318 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Carcinosarcoma of the breast: two case reports and review of the literature

BioMed Central — Tue, 06 Jan 2009 05:00:00 +0100

Carcinosarcoma of the breast, often referred to as metaplastic carcinoma of the breast, is a rare malignancy with two distinct cell lines described as a breast carcinoma of ductal type with a sarcoma-like component. The two cases we describe exemplify the aggressive nature of carcinosarcoma of the breast and support the findings that this tumor type does not express the common receptors found in other breast carcinomas. These case reports also emphasize the need for investigating the role for blockade of the HER-1/EGFR receptor with targeted therapies when found to be over-expressed in the primary tumor. (Source: BioMed Central)

Metastasis of carcinosarcoma of oesophagus to gastrostomy site

The British Journal of Oral & Maxillofacial Surgery — Wed, 31 Dec 2008 00:00:00 +0100

Abstract: Patients with head and neck cancers need a percutaneous endoscopic gastrosotomy (PEG) before start of treatment to ensure adequate nutrition because worsening dysphagia during chemo radiation [Nicholson FB, Korman MG, Richardson MA. Percutaneous endoscopic gastrostomy: a review of indications, complications and outcome. J. Gastroenterol Hepatol 2000; 15: 21–5; Beer KT, Krause KB, Zuercher T, Stanga Z. Early percutaneous endoscopic gastrostomy insertion maintains nutritional state in patients with aerodigestive tract cancer. Nutr Cancer 2005; 52: 29–34.]. However implantation of original tumor to the gastrostomy exit site is rare but serious complication of this procedure and here we report a case of PEG site metastasis along with relevant review of literature. (Source: The Br...

Metastasis of carcinosarcoma of oesophagus to gastrostomy site.

The British Journal of Oral & Maxillofacial Surgery — Mon, 29 Dec 2008 05:00:00 +0100

Authors: Hameed H, Khan YI Patients with head and neck cancers need a percutaneous endoscopic gastrosotomy (PEG) before start of treatment to ensure adequate nutrition because worsening dysphagia during chemo radiation [Nicholson FB, Korman MG, Richardson MA. Percutaneous endoscopic gastrostomy: a review of indications, complications and outcome. J. Gastroenterol Hepatol 2000; 15: 21-5; Beer KT, Krause KB, Zuercher T, Stanga Z. Early percutaneous endoscopic gastrostomy insertion maintains nutritional state in patients with aerodigestive tract cancer. Nutr Cancer 2005; 52: 29-34.]. However implantation of original tumor to the gastrostomy exit site is rare but serious complication of this procedure and here we report a case of PEG site metastasis along with relevant review of literature...

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Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis.

Lung Cancer — Fri, 26 Dec 2008 05:00:00 +0100

Authors: Froio E, D'Adda T, Fellegara G, Martella E, Caruana P, Pruneri G, Pesci A, Rindi G A 58-year-old woman underwent a curative total abdominal hysterectomy with bilateral salpingo-oophorectomy for a uterine carcinosarcoma. Fifteen months later, PET and CT scan revealed three pulmonary nodules and multiple lymphadenopathy. An atypical lung segmentectomy with dissection of the regional lymph nodes was performed. Two of the three nodules showed morphological and immunohistochemical profiles consistent with the diagnosis of large-cell neuroendocrine carcinoma (LCNEC). The third nodule, the surrounding pulmonary parenchyma and lymph nodes showed diffuse sarcoid granulomatosis. Re-review of the histology of the uterine carcinosarcoma revealed LCNEC morphology with immunohistochemical a...

Chemotherapy-Induced Neuronal Maturation in Sinonasal Teratocarcinosarcoma—a Unique Observation

Head and Neck Pathology — Thu, 04 Dec 2008 06:51:30 +0100

We report the first case of a SNTCS in 23 year old male treated with neo-adjuvant chemotherapy followed by cranio-facial resection. The resection specimen displayed cellular maturation in the neuroectodermal component. The patient presented with a short history of nasal obstruction, epistaxis and headache. On imaging, a bone destroying lesion of left paranasal sinuses and nasal cavity was identified. The diagnosis of SNTCS could be offered only on the third biopsy which showed heterogeneous admixture of primitive neuroectodermal, epithelial and mesenchymal elements. An adequate sampling with high index of suspicion is needed to catch hold this rare tumor. Tumor was excised after 4 cycles of neo-adjuvant chemotherapy. On microscopic examination, it showed similar epithelial and m...

Ultrastructural characteristics of nephroblastomas and their relation to DNA ploid

Chinese Journal of Cancer Research — Mon, 01 Dec 2008 06:55:04 +0100

Abstract Fifty-one cases of nephroblastoma were pathologically studied by light and electron microscopy as well as microspectrophotometry. Under light and electron microscope, the tumor appeared to be carcinosarcoma structurally, consisting of epithelial, sarcomatous and undifferentiated tumor cells. Their ultrastructural feature was similar to that of renal tubular epithelial cells and fibroblast. It could differentially be diagnosed from renal mesoblastic tumors by electron microscopy when the tumor was mainly composed of sarcomatous cells. Microspectrophotometer measurement showed an increased mean nuclear DNA content (DI>1.04), belonging to aneuploid tumor, which together with polyploid cells, serving as one of the important characteristics of malignant tumors. In a...

What is your diagnosis? Ventral neck mass in a dog.

Veterinary Clinical Pathology — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Fernandez NJ, Clark EG, Larson VS : A 14-year-old male Labrador Retriever was presented for lethargy and collapse. On physical examination, numerous abnormalities were found, including a large ventral neck mass (100 cm(3)) in the area of the thyroid gland. Fine-needle aspirates revealed 2 apparent populations of cells: one suspected to be a well-differentiated thyroid carcinoma, and the other consisting of large pleomorphic to spindloid cells suggestive of sarcoma. Two days later, the dog died at home. A full necropsy was not performed, but examination of the head and neck revealed a well-encapsulated mass adjacent to the cranial trachea and larynx. A section of the mass was evaluated histologically and a diagnosis of anaplastic thyroid carcinoma was made. Immunohistochemical ...

Uterine sarcoma 2008

Current Oncology Reports — Sun, 23 Nov 2008 06:50:16 +0100

Abstract Uterine sarcomas are a group of rare and usually aggressive soft tissue cancers. They have a wide range of histologic appearances, from myomatous to osteous to stromal. The three major subtypes of uterine sarcomas (listed in decreasing order of incidence) are carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma. Most patients with uterine sarcomas are middle-to older-aged women who present with abnormal uterine bleeding or pelvic mass, which may be confused with leiomyoma. Surgery—including hysterectomy and resection of disease—serves as the main treatment modality. Adjuvant therapies, including radiation, chemotherapy, and/or hormonal therapy, have limited benefit on overall survival; however, this may be due to the lack of good randomized controlle...

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Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome.

Annals of Diagnostic Pathology — Wed, 12 Nov 2008 12:29:48 +0100

We describe the clinicopathologic features and management of a well-documented example of this unique entity that involved a 41-year-old Hispanic man. The patient presented with a history of multiple episodes of epistaxis, nasal obstruction and frontal headaches. Computerized tomography scans and magnetic resonance imaging revealed a large mass filling the left nasal cavity and extending to the cribriform plate with involvement of the ethmoid sinuses, lamina papyracea, and orbit. The patient underwent a complex procedure for a T3N0 tumor. Histologic examination revealed a heterogeneous admixture of epithelial, mesenchymal, and neuroepithelial elements. The mesenchymal components consist of fibrous stroma and myxomatous areas, labeled with calponin and smooth muscle actin. The epithelial co...

TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder

Modern Pathology AOP — Fri, 07 Nov 2008 05:00:00 +0100

Authors: Andrew B Armstrong, Mingsheng Wang, John N Eble, Gregory T MacLennan, Rodolfo Montironi, Puay-Hoon Tan, Antonio Lopez-Beltran, Shaobo Zhang, Lee Ann Baldridge, Helena Spartz & Liang Cheng (Source: Modern Pathology AOP)

Prognostic significance of race and tumor size in carcinosarcoma of gallbladder: a meta-analysis of 68 cases.

International Journal of Clinical and Experimental Pathology — Sun, 02 Nov 2008 19:20:04 +0100

Authors: Zhang L, Chen Z, Fukuma M, Lee LY, Wu M Carcinosarcoma of gallbladder, also named sarcomatoid carcinoma and spindle cell carcinoma, is a rare neoplasm. Its clinical features and prognostic determinants are still poorly understood due to its rarity. We identified 67 qualified cases in published literatures and 1 in our institution. 52 of them were females and 16 males (F:M=3.25:1). 27 were Japanese patients and the rest were mainly from the United States and Europe. The mean age was 68.8 years (median 68 years, range 45-91 years). The average tumor size was 6.9 cm (median 5 cm, range 1.0-24.0 cm, n=49). Adenocarcinoma was the most common epithelial component (79.2%) and squamous cell carcinoma was the least common (9.4%). Spindle cell type was the most common mesenchymal compon...

Malignant phyllodes tumour with intraductal and invasive carcinoma and lymph node metastasis.

Singapore Medical Journal — Sat, 01 Nov 2008 04:00:00 +0100

We describe a 51-year-old woman with a malignant phyllodes tumour with foci of intraductal carcinoma within the tumour and adjacent breast tissue. Though the carcinoma was found to be invasive based on the presence of carcinomatous lymph node metastasis, extensive sampling did not yield an invasive component within the breast, probably because of the marked stromal overgrowth of the phyllodes. A malignant phyllodes tumour with foci of intraductal carcinoma and axillary lymph node metastases was diagnosed rather than carcinosarcoma. Chemotherapy and irradiation were included in the postoperative management. Coexistence of phyllodes tumour and carcinoma is rare, and extensive sampling may be necessary to find the foci of carcinoma within an extensive and obviously malignant stromal overgrowt...

Laryngeal true malignant mixed tumor

Head — Tue, 28 Oct 2008 04:00:00 +0100

We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery. Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues. Immunohistochemical analyses showed a peculiar expression of myoepithelial markers such as p63 and calponin in the glandular epithelial component, whereas malignant spindle cell proliferation was immunoreactive for calponin and actin.These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell. Despite the unfavorable prognosis that has always been described for these neoplasms, the patient is alive with no evidence of recurrences 5 years after surgery. © 2008 W...

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A phase 1 trial of 2 dose schedules of ABT-510, an antiangiogenic, thrombospondin-1-mimetic peptide, in patients with advanced cancer

Cancer — Fri, 17 Oct 2008 04:00:00 +0100

ABT-510 is a substituted nonapeptide that mimics the antiangiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). The current study was designed to establish the safety of ABT-510 in the treatment of patients with advanced malignancies on a once-daily (QD) and twice-daily dosing schedule.Patients were randomly assigned to 1 of 6 dosing regimens: 20 mg, 50mg, or 100 mg QD or 10 mg, 25 mg, or 50 mg twice daily. ABT-510 was administered by subcutaneous bolus injection in cycles of 28 days. Tumor response and disease progression were monitored at 8-week intervals by computed tomography scan or magnetic resonance imaging.Thirty-six patients were randomly assigned in equal numbers to the 6 study regimens, with an additional 13 patients randomized to the 10-mg-twice-daily and 50-mg...

Carcinosarcoma of the oesophagus.

Singapore Medical Journal — Wed, 01 Oct 2008 04:00:00 +0100

Authors: Gaur DS, Kishore S, Saini S, Pathak VP Oesophageal cancer is the third most common gastrointestinal cancer, especially in the Asian population. Only 1.3 percent of oesophageal cancers cases present as carcinosarcomas. A 43-year-old male who is a chronic smoker presented with progressive dysphagia and weight loss. On barium swallow, a large polypoidal mass was found filling the oesophageal lumen. Gross and microscopical findings along with immunohistochemistry helped in establishing its diagnosis as oesophageal carcinosarcoma. This unusual and controversial malignant tumour is biphasic in nature, composed of both carcinomatous and sarcomatous elements. This case showed a rarer feature that the epithelial element was of the adenocarcinomatous type instead of the expected squamou...

Association between ovarian endometriosis and malignancy in the peri-menopausal period: report of two cases and review of the literature

Gynecological Surgery — Thu, 25 Sep 2008 07:21:41 +0100

We report two cases of peri-menopausal women in which endometriosis was associated to ovarian malignancy. The first case was a 49-year-old woman who underwent laparoscopic oophorectomy for an ovarian endometrioid cyst. Definitive histology showed ovarian endometrioid cyst with endometrioid and clear cell carcinoma. Subsequently, surgical restaging was performed. The other case was a 49-year-old woman who underwent hysterectomy and bilateral oophorectomy for an ovarian mass suggestive of endometriosis and uterine myomas. At frozen section examination, ovarian adenocarcinoma was found and staging procedure was performed. Definitive histology showed carcinosarcoma of the ovary with areas of endometriod adenocarcinoma. Given the non-infrequent association between ovarian endometriosis a...

Malignant Mullerian Mixed Tumor of the Ovary Associated With Yolk Sac Tumor, Neuroepithelial and Trophoblastic Differentiation (Teratoid Carcinosarcoma).

International Journal of Gynecological Pathology — Sat, 20 Sep 2008 09:56:39 +0100

Page: 515DOI: 10.1097/PGP.0b013e31817b06c7Authors: Garcia-Galvis, Olga F. M.D.; Cabrera-Ozoria, Claudia M.D.; Fernandez, Jose Aneiros M.D.; Stolnicu, Simona M.D.; Nogales, Francisco F. M.D. (Source: International Journal of Gynecological Pathology)

Carcinosarcoma of the esophagus producing granulocyte-colony stimulating factor: report of a case

Esophagus — Thu, 18 Sep 2008 06:49:24 +0100

Abstract A 51-year-old man was admitted to the hospital for dysphagia, pyrexia, and leukocytosis. The serum level of granulocyte-colony stimulating factor (G-CSF) was elevated. Barium esophagography and endoscopy revealed a polypoid tumor in the middle portion of the esophagus. After an esophagectomy, the leukocyte count and serum G-CSF level normalized. The pathological diagnosis was carcinosarcoma of the esophagus with two components: namely, squamous cell carcinoma and sarcoma. Moreover, cancer cells were positive for G-CSF antibody. These findings confirmed that the esophageal carcinosarcoma in this case was a G-CSF-producing tumor. Although a G-CSF-producing esophageal carcinosarcoma is very rare, this disease should be considered when a patient has symptoms such as l...

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Basal cell carcinoma with a sarcomatous component (carcinosarcoma): A series of 5 cases and a review of the literature.

Journal of the American Academy of Dermatology — Wed, 17 Sep 2008 17:19:32 +0100

Authors: Rose RF, Merchant W, Stables GI, Lyon CL, Platt A Cutaneous carcinosarcomas are rare biphasic malignant tumors with a malignant epithelial component together with malignant stroma. Five cases treated in the Yorkshire region of England between 2003 and 2006 are presented. The patients were male with an age range from 58 to 84 years. Four lesions occurred on the face and one on the trunk. Each tumor had an epithelial component resembling a typical nodular basal cell carcinoma. The stromal components demonstrated atypical spindle cells and tumor giant cells, undifferentiated stroma, or osteoid formation. All underwent surgical excision and none showed evidence of recurrence (follow-up 3-17 months, one death from unrelated causes). The recent literature concerning the pathogenesis...

Rare and unusual histological variants of prostatic carcinoma: clinical significance

BJU International — Fri, 12 Sep 2008 04:00:00 +0100

We review the clinicopathological features of the following unusual histological variants of prostatic carcinoma: small cell carcinoma, ductal adenocarcinoma, sarcomatoid (carcinosarcoma), basal cell, squamous cell and adenosquamous, and urothelial carcinoma. These variants are rare and account for 5[ndash]10% of carcinomas that originate in the prostate. Some develop from acinar adenocarcinoma after hormonal or radiation therapy. They are usually aggressive tumours that often present with secondary deposits. The outcome is generally poor. Only basal cell carcinoma is seen as a low-grade carcinoma. (Source: BJU International)

Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma

Pathology International — Wed, 10 Sep 2008 04:00:00 +0100

Herein is presented a case of carcinosarcoma of the pancreas in an 82-year-old woman, analyzed on immunohistochemistry and K-ras sequence. The tumor, which arose in the pancreas head, was removed on pancreaticoduodenectomy. The patient died, however, of disseminated intravascular coagulation syndrome from postoperative sepsis 13 days later. Microscopically, the tumor consisted of malignant epithelial (well-differentiated adenocarcinoma cells) and mesenchymal (spindle-shaped tumor cells) components. The adenocarcinoma cells had positive immunostaining for cytokeratin AE1/AE3, cytokeratin 7, epithelial membrane antigen (EMA), CEA and carbohydrate antigen 19-9 (CA 19-9), while focal staining of these proteins was observed in the sarcomatous cells. In contrast, the sarcomatous cells had diffus...

Simultaneous primary carcinosarcoma of the uterus and the bilateral fallopian tubes: an extremely rare case and review of the literature

Gynecological Surgery — Wed, 03 Sep 2008 11:13:10 +0100

Abstract Malignant mixed mullerian tumors (MMMTs) are very rare neoplasms of the fallopian tube, consisting of <1% of all genital sarcomas. The prognosis of fallopian tube MMMTs is poor. In most cases, the patient is lost in the first 2 years. A case of simultaneous primary carcinosarcoma of the uterus and the bilateral fallopian tubes is reported. Six regimens of carboplatin/paclitaxel combination therapy were administered to the patient after surgery. During the 32-month follow-up of the patient, recurrence and metastasis were not determined. The speculations about the pathological origins and the treatment of MMMTs still continue. Although it is an uncommon occurrence, it has been shown that these tumors may exist simultaneously in different genital organs too. ...

Primary Mixed Squamous Carcinoma and Osteosarcoma (Carcinosarcomas) of the Lung Have a CGH Mapping Similar to Primitive Squamous Carcinomas and Osteosarcomas.

Diagnostic Molecular Pathology — Wed, 27 Aug 2008 09:17:37 +0100

Page: 151DOI: 10.1097/PDM.0b013e31815d05b3Authors: Pardo, Javier MD, PhD; Aisa, Gregorio MD; Alava, Enrique de MD, PhD; Sola, Jesus J. MD, PhD; Panizo, Angel MD, PhD; Rodriguez-Spiteri, Natalia MD; Garcia, Juan L. MD; Torre, Wenceslao MD (Source: Diagnostic Molecular Pathology)

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A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma.

Gynecologic Oncology — Tue, 26 Aug 2008 04:00:00 +0100

CONCLUSIONS: Our study corroborates GOG 150 results, and shows that paclitaxel-carboplatin appears to be an efficacious adjuvant chemotherapy regimen for completely resected uterine carcinosarcoma. The role of adjuvant RT in addition to chemotherapy warrants further investigation. PMID: 18755503 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Carcinosarcoma of the Ampulla of Vater.

Journal of Clinical Gastroenterology — Tue, 22 Jul 2008 09:13:29 +0100

Page: 864DOI: 10.1097/MCG.0b013e31804b218bAuthors: Tanaka, Akira MD, PhD *; Hirabayashi, Kenichi MD +; Tobita, Kosuke MD, PhD *; Okamura, Takuho MD *; Takashimizu, Shinji MD, PhD ++; Ishii, Masanori MD *; Dowaki, Shoichi MD, PhD *; Yasuda, Masanori MD, PhD +; Mine, Tetsuya MD, PhD ++; Ogoshi, Kyoji MD, PhD *; Imaizumi, Toshihide MD, PhD *; Makuuchi, Hiroyasu MD, PhD * (Source: Journal of Clinical Gastroenterology)

Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells.

Cellular and Molecular Biology Letters — Wed, 16 Jul 2008 18:10:32 +0100

Authors: Wybieralska E, Koza M, Sroka J, Czyz J, Madeja Z The results of several experimental studies have shown that ascorbic acid inhibits tumor growth and metastasis. Ascorbic acid is an antioxidant that acts as a scavenger for a wide range of reactive oxygen species (ROS). Both tumour metastasis and cell migration have been correlated with the intracellular ROS level, so it was postulated that the inhibitory effect of ascorbic acid derivatives on cell motility may be caused by scavenging of ROS. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and the cell displacement were inhibited by ascorbic acid applied in concentrations ranging from 10 to 250 microM. This effect correlated with a reduction in the intracellular ROS level in...

Gallbladder Sarcoma: A Clinicopathological Study of Seven Cases from the UK and Austria with Emphasis on Morphological Subtypes

Digestive Diseases and Sciences — Fri, 11 Jul 2008 07:26:00 +0100

Conclusion PGBS are rare and mainly occur in the gallbladder body in middle-aged females. They generally present with acute cholecystitis and have a very poor prognosis. A variety of sarcoma types are found with MFH being the predominant variant. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-008-0358-zAuthors E. A. Husain, Aberdeen Royal Infirmary Departments of Histopathology Aberdeen UKR. J. Prescott, Blackburn Royal Infirmary Department of Pathology Blackburn UKS. A. Haider, Queen’s Medical Centre, University of Nottingham Division of Pathology, School of Molecular Sciences Nottingham NG7 2UH UKR. W. T. Al-Mahmoud, Queen’s Medical Centre, University of Nottingham Division of Pathology, School of Molecular Sciences Nottingham NG7 2UH UKB. G. Zelger, Un...

Combination chemotherapy with carboplatin, paclitaxel and pegylated liposomal doxorubicin for advanced or recurrent carcinosarcoma of the uterus: Clinical experience of a single institution.

Gynecologic Oncology — Thu, 03 Jul 2008 04:00:00 +0100

CONCLUSION: The combination of carboplatin, paclitaxel and pegylated liposomal doxorubicin appears to have activity in advanced, persistent or recurrent endometrial carcinosarcoma with an acceptable toxicity profile. PMID: 18602677 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Uterine Carcinosarcomas and Grade 3 Endometrioid Cancers: Evidence for Distinct Tumor Behavior.

Obstetrics and Gynecology — Tue, 01 Jul 2008 04:00:00 +0100

CONCLUSION: Carcinosarcomas present at more advanced stage and have worse survival than grade 3 endometrioid carcinomas. Carcinosarcomas may represent a distinct biologic entity. LEVEL OF EVIDENCE: II. PMID: 18591309 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)

The Management of Uterine Sarcomas.

Clinical Oncology — Fri, 20 Jun 2008 04:00:00 +0100

This article reviews the surgical and adjuvant treatments for these tumours. The importance of surgical staging is discussed and the need for careful review of the pathology. Newer classifications will help to distinguish the different types as we now recognise that carcinosarcomas are most likely to be epithelial cancers rather then sarcomas. A critical discussion of the roles of both adjuvant chemotherapy and radiation are discussed. Some recent important trials have helped to give better evidence base on which to plan future treatment strategies. The routine place of adjuvant pelvic radiation seems limited as it only leads to improved local control. To date chemotherapy studies have equally failed to show a benefit. More trials are needed to address these issues. We cannot be complacent...

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature.

Ophthalmology — Mon, 16 Jun 2008 04:00:00 +0100

CONCLUSIONS: Carcinosarcoma may arise in the orbit or extend into the orbit from the paranasal sinuses. This malignant neoplasm should be aggressively treated with a combination of surgical resection, chemotherapy, and radiation therapy. PMID: 18562006 [PubMed - as supplied by publisher] (Source: Ophthalmology)

Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma

Archives of Gynecology and Obstetrics — Thu, 12 Jun 2008 06:23:31 +0100

Conclusion Although cardiac tamponade is rare and has a poor prognosis, it is important for physicians to consider this possibility in the course of treating of uterine carcinosarcoma. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0701-9Authors Shoko Shimizu, Tokyo Women’s Medical University Department of Obstetrics and Gynecology, Faculty of Medicine 8-1 Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanMasazumi Yajima, Tokyo Women’s Medical University Department of Obstetrics and Gynecology, Faculty of Medicine 8-1 Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanAsuka Yoshii, Tokyo Women’s Medical University Department of Obstetrics and Gynecology, Faculty of Medicine 8-1 Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanToshio Nishikawa, Tokyo Women�...

Carcinosarcoma of the rectosigmoid colon in a 13-year-old girl

Pathology International — Wed, 11 Jun 2008 09:07:11 +0100

Pathology International, Volume 58, Issue 7, Page 445-450, July 2008. Reported herein is an unusual case of carcinosarcoma of the colon. A 13-year-old girl was transferred to Chonbuk National University Hospital, Korea with a known pelvic mass. CT and magnetic resonance imaging confirmed a large pelvic mass. A sarcoma was ... (Source: Pathology International)

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BiPar Sciences Expands Clinical Development Of BSI-201 With Phase 2 Trial In Uterine Cancer

Cancercompass News: Gynecological Cancer — Tue, 10 Jun 2008 05:00:00 +0100

BiPar Sciences, Inc. announced it has expanded its clinical trials program through the initiation of an additional Phase 2 study of its lead product candidate BSI-201. The trial will assess BSI-201, the first ADP-ribose polymerase (PARP) inhibitor in the company's DNA repair portfolio, for the treatment of uterine carcinosarcoma or malignant mixed mullerian tumors. This multi-center, open-label, single-arm study in patients with recurrent or advanced uterine carcinosarcomas will evaluate BSI-201 in combination with standard treatment and is being conducted by the Gynecologic Oncology Group, a National Cancer Institute-funded research organization which focuses on gynecologic malignancies. The primary objective of this trial is to determi... (Source: Cancercompass News: Gynecological Cancer...

[Uterine sarcomas: Clinical and histopathological aspects. Report on 15 cases.]

Gynecologie, Obstetrique & Fertilite — Wed, 04 Jun 2008 04:00:00 +0100

CONCLUSION: Uterine sarcomas are rare cancers with poor prognosis. Their symptomatology is non-specific and they are characterized by histopathological diversity. Early diagnosis is essential because patients' survival is correlated to tumour stage. However, preoperative diagnosis is often difficult and definitive diagnosis is frequently achieved after pathological analysis of hysterectomies specimens. PMID: 18538624 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)

So-called Carcinosarcoma of the Esophagus: Report of a Case.

Journal of Nippon Medical School — Sun, 01 Jun 2008 04:00:00 +0100

Authors: Akagi I, Miyashita M, Makino H, Nomura T, Ohkawa K, Tajiri T The carcinosarcoma of the esophagus is a rare malignant neoplasm consisting of both carcinomatous and sarcomatous components. A case of so-called carcinosarcoma of the esophagus is described herein. A 69-year-old man presented with dysphagia and was admitted to our hospital. Imaging studies revealed a localized ulcerative tumor in the middle intrathoracic esophagus without any invasion or metastasis. The patient was initially thought to have squamous cell carcinoma and underwent subtotal esophagectomy with lymphadenectomy. Final diagnosis of the tumor was so-called carcinosarcoma of the esophagus. The patient had an uneventful postoperative course and showed no evidence of recurrence or metastasis in the 4-year posto...

BiPar Sciences Expands Clinical Development Of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial In Uterine Cancer

Cancer / Oncology News From Medical News Today — Thu, 29 May 2008 07:00:00 +0100

Do you have any information on the epidemiology of endometrial carcinosarcomas and current treatment regimes?

NLH Question Answering Service — Tue, 27 May 2008 09:22:38 +0100

We found few reviews on this topic. A CancerBackUp patient information leaflet [1] states"Carcinosarcoma is a rare tumour. (Source: NLH Question Answering Service)

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Carcinosarcoma of the uterus: radiologic-pathologic correlations with magnetic resonance imaging including diffusion-weighted imaging.

Magnetic Resonance Imaging — Wed, 21 May 2008 04:00:00 +0100

Authors: Kato H, Kanematsu M, Furui T, Imai A, Hirose Y, Kondo H, Goshima S, Tsuge Y The authors describe the MRI findings, including diffusion-weighted imaging findings, of histopathologically proven uterine carcinosarcoma in four postmenopausal women. In three of four patients, diffusion-weighted images clearly revealed hypointense areas corresponding to hypocellular regions caused by intratumoral necrosis, and apparent diffusion coefficient (ADC) mapping images indicated that necrotic areas had high ADC values. In the remaining patient, diffusion-weighted and ADC mapping images clearly distinguished components of adenocarcinoma from sarcoma. In all patients, diffusion-weighted and ADC mapping images precisely reflected histopathological findings. Diffusion-weighted images were found...

Primary hepatic sarcomas: CT findings

European Radiology — Thu, 08 May 2008 06:07:48 +0100

Abstract Primary hepatic sarcomas are rare tumors that are difficult to diagnose clinically. Different primary hepatic sarcomas may have different clinical, morphologic, and radiological features. In this pictorial review, we summarized computed tomography (CT) findings of some relatively common types of hepatic sarcomas, including angiosarcoma, epithelioid hemangioendothelioma (EHE), liposarcoma, undifferentiated embryonal sarcoma (UES), leiomyosarcoma, malignant fibrous histiocytoma (MFH), and carcinosarcoma (including cystadenocarcinosarcoma). To our knowledge, hepatic cystadenocarcinosarcoma has not been described in the English literature. The CT findings in our case are similar to that of cystadenocarcinoma, a huge, multilocular cystic mass with a large mural nodule ...

[Clinical analysis of 12 cases of uterine carcinosarcoma.]

Chinese Journal of Cancer — Thu, 01 May 2008 04:00:00 +0100

CONCLUSIONS: Primary surgery is the main treatment for uterine carcinosarcoma. The prognosis of uterine carcinosarcoma is associated with surgicopathologic stage and treatment modalities. PMID: 18479602 [PubMed - in process] (Source: Chinese Journal of Cancer)

Pseudovacuoles--immobilized by high-pressure freezing--are associated with blebbing in walker carcinosarcoma cells.

Journal of Microscopy — Thu, 01 May 2008 04:00:00 +0100

Authors: Vanhecke D, Bellmann R, Baum O, Graber W, Eggli P, Keller H, Studer D By applying high pressure freezing and freeze-substitution, we observed large inclusions of homogeneous appearance in the front of locomoting Walker carcinosarcoma cells that have not been described earlier. Live cell imaging revealed that these inclusions were poor in lipids and nucleic acids but had a high lysine (and hence protein) content. Usually one such structure 2-5 mum in size was present at the front of motile Walker cells, predominantly in the immediate vicinity of newly forming blebs. By correlating the lysine-rich areas in fixed and embedded cells with electron microscopic pictures, inclusions could be assigned to confined, faintly stained cytoplasmic areas that lacked a surrounding membrane; th...

Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur.

Pathology, Research and Practice — Thu, 24 Apr 2008 04:00:00 +0100

We report a new type of secondary malignant giant cell tumor of bone, the malignancy of which was assigned to a carcinosarcoma, i.e., osteosarcoma and squamous cell carcinoma. It occurred 25 years after curettage and bone graft surgery under the diagnosis of giant cell tumor of the right distal femur. Although secondary malignant giant cell tumor is known as a sarcoma arising at the site of a previously diagnosed giant cell tumor, this case should be regarded as a new type of secondary malignant giant cell tumor of bone. PMID: 18440162 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

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Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas.

International Journal of Oncology — Tue, 22 Apr 2008 21:23:03 +0100

Authors: Sorbe B, Johansson B In a complete geographic series of 155 cases of primary uterine sarcomas, prophylactic pelvic irradiation was used as standard postoperative therapy in the majority of the cases. Vaginal brachytherapy was also added as a boost. The histology was leiomyosarcoma in 62 cases (40%), carcinosarcoma in 60 (39%), endometrial stromal sarcoma in 25 (16%), and other types in 8 cases (5%). The primary surgery was extended hysterectomy in 11 cases (7%), simple hysterectomy in 110 (71%), and supravaginal hysterectomy in 12 (8%). In 22 cases (14%) no major surgery was possible. In the complete series, 62 recurrences (40%) were recorded. Local (9%), regional (9%), and distant recurrences (28%) were the most frequent. The type of surgery was associated with the risk of tu...

Endometrioid endometrial adenocarcinoma recurring as carcinosarcoma

Journal of Obstetrics and Gynaecology Research — Wed, 16 Apr 2008 01:19:40 +0100

Journal of Obstetrics and Gynaecology Research, Volume 34, Issue 2, Page 279-282, April 2008. Abstract Müllerian carcinosarcoma is currently regarded as a metaplastic (sarcomatous) carcinoma. Only five cases of pure ovarian adenocarcinoma recurring as carcinosarcoma have been documented in the literature. There are no documented cases of ... (Source: Journal of Obstetrics and Gynaecology Research)

Primary cutaneous carcinosarcoma: case report with expanded immunohistochemical analysis

International Journal of Dermatology — Mon, 14 Apr 2008 23:00:16 +0100

International Journal of Dermatology, Volume 47, Issue 5, Page 496-501, May 2008. An 83-year-old woman presented with a nodular, eroded tumor on the skin between the nose and the upper lip of 18 months’ duration. There were no palpable lymph nodes and no infiltrates on chest radiography. Complete surgical excision showed a tumor ... (Source: International Journal of Dermatology)

[The diagnostic problem of uterine sarcomas: Report on a case of carcinosarcoma mimicking a gastro-intestinal disease.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Fri, 11 Apr 2008 04:00:00 +0100

We present a case of uterine carcinosarcoma diagnosed retrospectively after surgical specimen analysis in a 69-year-old patient presenting gastro-intestinal complaints. At the time of diagnosis, the patient was in FIGO, stage IV. PMID: 18407437 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: An European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874).

European Journal of Cancer — Fri, 28 Mar 2008 04:00:00 +0100

Authors: Reed NS, Mangioni C, Malmström H, Scarfone G, Poveda A, Pecorelli S, Tateo S, Franchi M, Jobsen JJ, Coens C, Teodorovic I, Vergote I, Vermorken JB The management of uterine sarcomas continues to present many difficulties. Primary surgery is the optimal treatment but the role of post-operative radiation remains uncertain. In the mid-1980s, the European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study proposed a trial to evaluate adjuvant radiotherapy, as previous non-randomised studies had suggested a survival advantage and improved local control when post-operative radiation was administered. The study opened in 1987 taking 13 years to accrue 224 patients. All uterine sarcoma subtypes were permitted. Patients were required to have underg...

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Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas

APMIS — Wed, 05 Mar 2008 13:16:54 +0100

APMIS, Volume 116, Issue 2, Page 107-117, February 2008. Näyhä V, Stenbäck F. Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. APMIS 2008;116:107–17. Carcinosarcomas of the female genital tract are a heterogeneous group of ... (Source: APMIS)

[CASE REPORTS] Esophageal Carcinosarcoma With Basaloid Squamous Cell Carcinoma and Osteosarcoma

The Annals of Thoracic Surgery — Fri, 29 Feb 2008 05:00:00 +0100

We present here the first case of a carcinosarcoma of the esophagus that had a basaloid squamous cell carcinoma component in addition to the osteosarcoma and without a transitional zone. A 57-year-old man was diagnosed with a polypoid tumor in middle third of the esophagus causing dysphagia. Local recurrence and solitary pulmonary metastasis occurred 16 and 30 months after initial excision of the tumor, respectively. Prompt and aggressive surgical resection is mandatory for carcinosarcoma of the esophagus. (Source: The Annals of Thoracic Surgery)

Immunohistochemical analysis of carcinomatous and sarcomatous components in the uterine carcinosarcoma: A case report.

Pathology, Research and Practice — Mon, 25 Feb 2008 10:06:14 +0100

We report a case of 50-year-old peri-menopausal woman diagnosed to have early-stage (IB due to FIGO) uterine carcinosarcoma of the homologous type with superficial (3mm) myo-invasion. The patient showed no clinical symptoms of the disease and had no family history of female genital tract malignancies. Positive immunostaining for steroid receptors (estrogen-alpha and progesterone receptors), cytokeratin, and EGFR was detected only in the carcinomatous area, whereas beta-catenin, BCL-2, COX-2, p16(INK4a), PTEN, RB-1, and vimentin were immunoreactive in both components. Androgen receptor, CD10, desmin, HER-2/neu, and P53 were found to be negative either in the carcinomatous or in the sarcomatous area. Tumor proliferative activity was higher in the carcinomatous (25%) than in the sarcomatous (...

Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma.

The Annals of Thoracic Surgery — Sat, 23 Feb 2008 20:32:46 +0100

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

Cancer Research — Fri, 15 Feb 2008 05:00:00 +0100

Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. In carcinoma cells, EMT can be associated with increased aggressiveness, and invasive and metastatic potential. To assess the occurrence of EMT in human breast tumors, we conducted a tissue microarray–based immunohistochemical study in 479 invasive breast carcinomas and 12 carcinosarcomas using 28 different markers. Unsupervised hierarchical clustering of the tumors and statistical analysis showed that up-regulation of EMT markers (vimentin, smooth-muscle-actin, N-cadherin, and cadherin-11) and overexpression of proteins involved in extracellular matrix remodeling and invasion (SPARC, laminin, and fascin), together with reduction of characterist...

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Cutaneous Carcinosarcoma: Report of a Case with Myofibroblastic Sarcomatous Component

Dermatologic Surgery — Wed, 06 Feb 2008 15:56:30 +0100

Dermatologic Surgery, Volume 0, Issue 0, Page ???, OnlineEarly Articles. The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus

International Journal of Gynecological Cancer — Wed, 23 Jan 2008 21:37:03 +0100

International Journal of Gynecological Cancer, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Hoskins PJ, Le N. Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 2008.CA125 is a well-recognized marker for endometrial cancer. Uterine malignant mixed müllerian ... (Source: International Journal of Gynecological Cancer)

High-grade Trichoblastic Carcinosarcoma.

The American Journal of Dermatopathology — Wed, 23 Jan 2008 10:55:19 +0100

Page: 62DOI: 10.1097/DAD.0b013e31815c6c7fAuthors: Kazakov, Dmitry V MD, PhD *; Vittay, George MD +; Michal, Michal MD *; Calonje, Eduardo MD, Dip RCPath ++ (Source: The American Journal of Dermatopathology)

Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus

International Journal of Gynecological Cancer — Wed, 23 Jan 2008 00:00:00 +0100

Abstract. Hoskins PJ, Le N. Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 2008;18:1200[ndash]1201. CA125 is a well-recognized marker for endometrial cancer. Uterine malignant mixed müllerian tumors (MMMTs) are increasingly being recognized as an aggressive adenocarcinoma, not a sarcoma. There are no data in the literature regarding CA125 in this malignancy. One hundred twelve women with surgically staged MMMT, diagnosed between July 1990 and September 2005, had a retrospective chart review performed. Preoperative CA125 levels were available in 29 (26%) women. Seventeen (49%) women had levels above the upper limit of normal of 35 k[mu]/L. Mean levels increased with increasing surgical stage: stage ...

[Phase I and Clinical Pharmacology] Phase I Trial of the Novel Mammalian Target of Rapamycin Inhibitor Deforolimus (AP23573; MK-8669) Administered Intravenously Daily for 5 Days Every 2 Weeks to Patients With Advanced Malignancies

Journal of Clinical Oncology — Thu, 17 Jan 2008 05:00:00 +0100

Conclusion The MTD of this phase I trial using an accelerated titration design was determined to be 18.75 mg/d. Deforolimus was well tolerated and showed encouraging antitumor activity across a broad range of malignancies when administered intravenously on the QDx5 schedule. On the basis of these overall results, a dose of 12.5 mg/d is being evaluated in phase II trials. (Source: Journal of Clinical Oncology)

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Synchronous Carcinosarcoma of the Intrapancreatic Bile Duct and Carcinoma in Situ of Wirsung Duct: A Case Report.

Pancreas — Sun, 13 Jan 2008 09:41:45 +0100

Page: 95DOI: 10.1097/MPA.0b013e31813e64b5Authors: Aurello, Paolo MD, PhD *; Milione, Massimo MD +; Dente, Mario MD *; D'Angelo, Francesco MD, PhD *; Nigri, Giuseppe MD, PhD *; Del Gaudio, Massimo MD *; Valabrega, Stefano MD *; Ramacciato, Giovanni MD, FACS * (Source: Pancreas)

Molecular genetic aberrations of ovarian and uterine carcinosarcomas—a CGH and FISH study

Virchows Archiv — Sat, 12 Jan 2008 16:33:36 +0100

In this study, we used a molecular–genetic approach to elucidate the tumorigenesis of carcinosarcomas of these organs correlating our findings with the specific biphasic pattern of these tumors. We analyzed a series of 30 paraffin-embedded carcinosarcomas of the ovary and the uterus using comparative genomic hybridization (CGH) and fluorescence in-situ hybridization (FISH). In general, gains (85%) were observed more frequently, than losses (30%). Characteristic and frequent chromosomal amplification was observed on chromosome 8q and 20q (42 and 70%). FISH revealed c-myc (8q24.12) and ZNF217 (20q13.2) amplification in 78 and 87%. Amplification of ZNF217 was mostly seen in both tumor components, whereas amplification of c-myc was observed less often in the sarcomatous than in the car...

Pancreatic carcinosarcoma. Case report of multimodal therapy and review of the literature.

JOP — Fri, 11 Jan 2008 00:06:17 +0100

CONCLUSION: Carcinosarcoma of the pancreas is a very rare disease having a dismal prognosis. In addition to reviewing the literature on this entity, we present the first published case where gemcitabine was administered as a treatment modality in combination with surgery. PMID: 18182744 [PubMed - in process] (Source: JOP)

Primary adrenocortical sarcomatoid carcinoma: case report and review of literature

Virchows Archiv — Fri, 14 Dec 2007 15:57:04 +0100

We report a case of AC in a 31-year-old man presenting as a nonfunctional tumor, with a histological biphasic pattern combining few areas of differentiated AC and extensive areas of sarcomatoid spindle cell proliferation. The patient died 3 months of locoregional and distant recurrences after surgery despite apparently total tumor resection and VP16-cisplatinum chemotherapy. This case underlines the necessity to identify and isolate these carcinoma’s subtypes with worse prognosis and the difficulties to distinguish them from metastatic carcinomas and retroperitoneal sarcomas, in relation to the particular adrenal cortex immunoprofile. According to the World Health Organization principles of terminology, we suggest these tumors be collectively classified as “adrenal sarcomato...

Prognosis of uterine corpus cancer after tamoxifen treatment for breast cancer

Breast Cancer Research and Treatment — Fri, 07 Dec 2007 16:37:10 +0100

In conclusion, this large study clearly shows that tamoxifen-associated tumors have less favorable histological features and a worse survival. Our results can be applied when weighing risks and benefits of tamoxifen versus other hormonal agents used in the prevention and treatment of breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-007-9823-1Authors Wilhelmina E. Hoogendoorn, The Netherlands Cancer Institute Department of Epidemiology Plesmanlaan 121 1066 CX Amsterdam The NetherlandsHarry Hollema, University Medical Center Groningen, University of Groningen Department of Pathology Groningen The NetherlandsHester H. van Boven, The Netherlands Cancer Institute Department of Pathology Amsterdam The NetherlandsElisabeth Bergman, Comprehensive Cancer Cen...

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Sarcomatoid Carcinoma with a Predominant Basaloid Squamous Carcinoma Component: The First Report of an Unusual Biphasic Tumor of the Ureter

Japanese Journal of Clinical Oncology — Wed, 05 Dec 2007 05:00:00 +0100

Malignant tumors of the ureter that display biphasic patterns are very rare; they include carcinosarcomas, sarcomatoid carcinomas and carcinomas with pseudosarcomatous stroma. Although the distinction between carcinosarcomas and sarcomatoid carcinomas has been extensively discussed in the past, the recent World Health Organization classification of urinary tract tumors (2004) does not distinguish the two lesions and use the term sarcomatoid carcinoma to represent these biphasic tumors. The epithelial components of previously reported ureteral biphasic tumors comprise transitional cell carcinoma, squamous cell carcinoma, carcinoma in situ, small cell carcinoma and adenocarcinoma. In this paper, we report the first case of sarcomatoid carcinoma of the ureter with a predominant basaloid squam...

Uterine Carcinosarcoma in a Patient with Hereditary Non-polyposis Coli.

Clinical Oncology — Wed, 05 Dec 2007 05:00:00 +0100

Authors: Sayers I, Allerton R PMID: 18065215 [PubMed - as supplied by publisher] (Source: Clinical Oncology)

Radiographic and histological evaluation of bisphosphonate alendronate and metotrexate effects on rat mandibles inoculated with Walker 256 carcinosarcoma.

Acta Cirurgica Brasileira — Sat, 01 Dec 2007 05:00:00 +0100

CONCLUSION: The bisphosphonate alendronate exherted an osteoprotective effect and induced bone neoformation on the Walker 256 carcinosarcoma inoculated in rat mandibles. The combination of metotrexate with bisphosphonate alendronate is more successful than treatment with the agents alone in controlling the growth of neoplastic cells and in stimulating reactive new bone. Therefore, this may be an alternative treatment to malignant lesions of maxillaries with osteolysis. PMID: 18235934 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)

What is the cause of a woman's progressive dyspnea? Carcinosarcoma of lung.

Journal of Cardiology — Sat, 01 Dec 2007 05:00:00 +0100

Authors: Shimokawahara H, Tanaka H, Kashima K, Sonoda M, Nakamura K PMID: 18186315 [PubMed - indexed for MEDLINE] (Source: Journal of Cardiology)

Metastases to soft tissue

Cancer — Mon, 26 Nov 2007 05:00:00 +0100

Metastatic tumors presenting as soft tissue masses are relatively rare and can be the source of diagnostic confusion both clinically and pathologically. The authors' experience was reviewed at a large academic medical center over a 30-year period (1971-2000) with metastases to soft tissue.The tumors in the study included mainly lesions involving skeletal muscle or skeletal muscle and subcutaneous tissue of the upper and lower limbs, trunk, shoulders, and buttocks. Direct extension from tumors originating in bone or adjacent organs, tumors involving the skin or areas known to contain abundant lymph nodes (ie, axilla, groin), and hematopoietic malignancies were excluded.One hundred and eighteen cases were identified; 60 patients were women and 58 were men. The age range was 20 to 87 years (m...

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Antitumoral Activity Induced by Alkylating Agents Conjugated to Poly(maleic anhydride-alt-vinyl acetate)

Journal of Bioactive and Compatible Polymers — Tue, 20 Nov 2007 05:00:00 +0100

New polyanionic polymer conjugates with antitumoral activity are synthesized by chemically binding mustard type alkylating derivatives of di-(ß-chloroethyl)-amine and tri-(ß-chloroethyl)-amine, respectively, onto poly(maleic anhydride-alt-vinyl acetate). The structures of the compounds are verified by FTIR, 1H NMR, and elemental analysis. The antitumoral activity of these polymeric drugs is evaluated in vivo using carcinosarcoma Walker 256 solid tumors in Wister rats. The conjugates exhibit antitumor regression (ATR) values between 25 and 44% depending on comonomers' structure. In addition, an accumulation in the solid tumors (enhanced permeability and retention (EPR) effect) by these compounds is observed. These compounds also cause small organotropic effects, such as increase...

The Golden Standard In The Diagnosis Of Carcinosarcomas Is Histochemistry

Cancer / Oncology News From Medical News Today — Thu, 15 Nov 2007 11:00:00 +0100

A case study of carcinosarcoma has been published in the World Journal of Gastroenterology. The patient in the study was the first case of gastric carcinosarcoma obtained in this part of the world . The patient was admitted by Dr. Tomislav Randjelovic as surgeon and Dr. Branka Filipovic as gastroenterologist. The operation was performed by Dr. [click link for full article] (Source: Cancer / Oncology News From Medical News Today)

Clinical outcome of metastatic uterine leiomyosarcoma and carcinosarcoma in a single institute

Journal of Obstetrics and Gynaecology Research — Mon, 12 Nov 2007 19:40:16 +0100

Journal of Obstetrics and Gynaecology Research, Volume 33, Issue 6, Page 818-822, December 2007. Abstract Aim: To investigate the clinical outcome of uterine sarcomas, particularly in patients with pulmonary and abdominal metastasis, treated at a single institute. Methods: We identified five patients with uterine leiomyosarcoma (LMS), one patient ... (Source: Journal of Obstetrics and Gynaecology Research)

Prognostic Features of Surgical Stage I Uterine Carcinosarcoma.

The American Journal of Surgical Pathology — Sat, 27 Oct 2007 01:18:12 +0100

Page: 1653DOI: 10.1097/PAS.0b013e3181161ba3Authors: Ferguson, Sarah E. MD *; Tornos, Carmen MD +; Hummer, Amanda PhD ++; Barakat, Richard R. MD *; Soslow, Robert A. MD + (Source: The American Journal of Surgical Pathology)

18F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma

European Journal of Nuclear Medicine and Molecular Imaging — Sun, 21 Oct 2007 00:03:34 +0100

Conclusions The preliminary results suggest that 18F-FDG PET is beneficial in excluding falsely inoperable disease for curative therapy and in making a decision on palliation for better quality of life instead of aggressive treatment under the guidance of PET. PET seems to have limited value in post-therapy surveillance or restaging after failure. Content Type Journal ArticleCategory Original articleDOI 10.1007/s00259-007-0533-zAuthors Kung-Chu Ho, Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Nuclear Medicine and Molecular Imaging Center Taoyuan TaiwanChyong-Huey Lai, Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Gynecologic Oncology, Department of Obstetrics and Gynecology 5 Fu-Shin ...

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Esophageal carcinosarcoma with granulocyte colony-stimulating factor: a case report

Esophagus — Thu, 18 Oct 2007 16:17:15 +0100

Abstract A 62-year-old man was admitted to our hospital for dysphagia, leukocytosis, and pyrexia. The serum level of granulocyte colony-stimulating factor (G-CSF) was high and immunostaining of a biopsy specimen of esophageal tumor using anti-granulocyte-macrophage colony-stimulating factor (anti-GM-CSF) antibody demonstrated GM-CSF expression in the cytoplasm of the tumor cells. After esophagectomy, the leukocyte count and serum G-CSF level normalized. Histologically, this tumor was diagnosed as a carcinosarcoma with two components: squamous cell carcinoma and sarcoma. Tumor cells were also positive for G-CSF receptor, suggesting autocrine growth regulation by G-CSF. Moreover, tumor cells were positive for Ki-67, cyclin D1, p53, and epidermal growth factor receptor (EGFR),...

Granulocyte-colony stimulating factor-producing esophageal carcinosarcoma: a case report

Esophagus — Thu, 18 Oct 2007 16:17:14 +0100

Abstract An 80-year-old man presented at our hospital with chest oppression and vomiting. An endoscopic examination revealed a tumor in the lower portion of the esophagus, and the patient was diagnosed as possibly having esophageal carcinosarcoma based on a histological examination of endoscopic biopsy specimens. During the initial medical examination, the patient had a high leukocyte count and a high level of serum granulocyte-colony stimulating factor (G-CSF). Moreover, immunohistochemical examination revealed cells that were positive for antibodies against G-CSF. Therefore, we diagnosed the patient as possibly having a G-CSF-producing esophageal carcinosarcoma. The patient died of tumor 4 months after the initial diagnosis. Content Type Journal ArticleCategory CASE RE...

Differences in Survival Among Patients With Sarcomatoid Carcinoma, Carcinosarcoma and Urothelial Carcinoma of the Bladder.

The Journal of Urology — Fri, 12 Oct 2007 04:00:00 +0100

CONCLUSIONS: Compared to patients with urothelial carcinoma those with sarcomatoid carcinoma and carcinosarcoma present at a more advanced stage and are at greater risk for death even after adjusting for stage at presentation. The survival rate of sarcomatoid carcinoma is better than that of carcinosarcoma, offering some justification for the continued differentiation of these tumor types for clinical prognostication. PMID: 17936803 [PubMed - as supplied by publisher] (Source: The Journal of Urology)

Ovarian carcinosarcomas: Clinicopathological prognostic factors and evaluation of chemotherapy regimens containing platinum.

Gynecologic Oncology — Thu, 11 Oct 2007 04:00:00 +0100

CONCLUSIONS.: Hemorrhagic ascites can be used in the initial differential diagnosis of ovarian carcinosarcomas. Stage, optimal debulking and type of adjuvant therapy were statistically significant prognostic predictors of ovarian carcinosarcomas. We advise that patients with ovarian carcinosarcomas should be treated by optimal cytoreduction followed by adjuvant platinum/taxan or platinum/ifosfamide combinations. PMID: 17936342 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma.

Gynecologic Oncology — Wed, 10 Oct 2007 04:00:00 +0100

CONCLUSION.: Preoperative CA125 elevation is a marker of extrauterine disease and deep myometrial invasion in patients with uterine CS. Postoperative CA125 elevation is an independent prognostic factor for poor survival. These findings indicate that CA125 may be a clinically useful serum marker in the management of patients with CS. PMID: 17935762 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results

European Radiology — Fri, 05 Oct 2007 15:54:53 +0100

Abstract Our purpose is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC) measurement in differentiating malignant from benign uterine endometrial cavity lesions. We retrospectively evaluated 25 uterine endometrial cavity lesions in 25 female patients: endometrial carcinoma (n = 11), carcinosarcoma (n = 2), submucosal leiomyoma (n = 8), and endometrial polyp (n = 4). Diffusion-weighted images were performed at 1.5 T with b factors of 0–1,000/mm2. The region of interest was defined within the tumor on T2-weighted EPI image and then manually copied to an ADC map. Thereby, the ADC value was obtained. We compared ADC values between malignant and benign lesions using Student’s t-test. The mean and standard deviation of ADC values (�...

Carcinosarcoma of the stomach: A case report and review of the literature.

World Journal of Gastroenterology — Wed, 03 Oct 2007 00:05:40 +0100

We report the case of a 62-year-old man with gastric carcinosarcoma, along with its clinical, macroscopic and histopathological features. Macroscopically, a specimen of deformed stomach was obtained that measured 200 mm multiply 150 mm multiply 100 mm. A 150 mm multiply 100 mm multiply 50 mm exophytic tumoral mass (Borrmann type I) was found, which involved the posterior wall from the cardia to the antrum. Histopathologically, a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia, with interposed fascicles of fusiform atypical cells and numerous large, rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18, epithelial membrane antigen, carcinoembryonic antigen, chromogranin A and vimentin. Liver metastases were diagnosed 8 mo pos...

Carcinosarcoma of urinary bladder mimicking vesical calculus: a case report.

Indian Journal of Pathology and Microbiology — Mon, 01 Oct 2007 04:00:00 +0100

We report a 50 year old male who presented with a short history of gross hematuria. An ultrasonogram detected a mass arising from the right lateral wall of the urinary bladder. Computed tomography of the abdomen revealed that the mass was a calcified lesion mimicking a bladder stone. Cystoscopy confirmed the presence of the calcified lesion and biopsy revealed a rare biphasic tumor of the urinary bladder comprising of osteosarcoma and a papillary urothelial neoplasm of low malignant potential. The rarity of this tumor and its associated exuberant calcification make this case an interesting one. PMID: 18306574 [PubMed - indexed for MEDLINE] (Source: Indian Journal of Pathology and Microbiology)

Carcinosarcoma de la mama: un tumor de histogénesis controvertida

Clinical and Translational Oncology — Sun, 23 Sep 2007 18:22:04 +0100

We present, here, a patient with mammary carcinosarcoma a difficult diagnosis. Treatment for the patient was a modified radical mastectomy, and adjuvant therapy. Content Type Journal ArticleCategory Case ReportsDOI 10.1007/BF02710172Authors Juana Teresa Santiago Pérez, Hospital Clínico Quirúrgico Docente Dr. Salvador Allende Freyre de Andrade 114, entre Juan Delgado y D'Strampes Víbora 10500 Cíudad de la Habana CubaMercedes R. Pérez Vázquez, Hospital Clínico Quirúrgico Docente Dr. Salvador Allende Freyre de Andrade 114, entre Juan Delgado y D'Strampes Víbora 10500 Cíudad de la Habana CubaAmparo de la C. Rivera Valdespino, Hospital Clínico Quirúrgico Docente Dr. Salvador Allende Freyre de Andrade 114, entre Juan Delgado y D'Strampes Víbora 10500 Cíudad de la Habana Cu...

Robotic-Assisted Laparoscopic Cystoprostatectomy for Prostatic Carcinosarcoma - Abstract

UroToday — Tue, 11 Sep 2007 23:00:00 +0100

Department of Urology, University of California at Irvine, Orange, California 90803, USA. (Source: UroToday)

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A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus.

Gynecologic Oncology — Tue, 04 Sep 2007 04:00:00 +0100

CONCLUSION.: We did not find a statistically significant advantage in recurrence rate or survival for adjuvant CIM over WAI in patients with uterine CS. However, the observed differences favor the use of combination chemotherapy in future trials. PMID: 17822748 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Carcinosarcoma of the uterine cervix: Case report and discussion.

Gynecologic Oncology — Mon, 27 Aug 2007 04:00:00 +0100

Authors: Laterza R, Seveso A, Zefiro F, Formenti G, Mellana L, Donadello N, Donadello N, Riva C, Bolis P BACKGROUND.: Cervical carcinosarcomas are rare neoplasms; optimal treatment is unclear. CASE 1.: A 42-year-old woman underwent abdominal hysterectomy because of bleeding, anaemia and uterine fibromatosis. Histology showed a homologous carcinosarcoma of the cervix. Laparoscopic re-staging (pelvic lymphadenectomy, bilateral salpingo-oophorectomy) was negative for neoplasia. Adjuvant chemotherapy with ifosfamide and cisplatin was performed. At 48 months of follow-up, the patient is NED. CASE 2.: A 74-year-old woman reporting vaginal bleeding, with carcinosarcoma on the cervical biopsy, underwent radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraortic lymphadenectomy...

Endometrial carcinosarcoma presenting as a tibial metastasis

International Journal of Clinical Oncology — Tue, 14 Aug 2007 07:31:15 +0100

Abstract Metastasis to a lower-extremity bone is an extremely rare event in patients with endometrial carcinoma. A 64-year-old woman presented with progressive right leg pain but no gynecologic complaints. A diagnostic workup revealed primary endometrial carcinosarcoma with an isolated tibial metastasis. Though the patient received only local irradiation to the tibial lesion, complete resolution of symptoms resulted. Six months after the radiotherapy, the intraabdominal disease progressed and the patient died. We note that tibial metastasis is one of the possible presenting symptoms in patients with endometrial malignant tumors. Irradiation can improve their quality of life and so may be effective in the management of symptomatic tibial metastasis. Content TypeJournal Ar...

Prognoses and Prognostic Factors of Carcinosarcoma, Endometrial Stromal Sarcoma and Uterine Leiomyosarcoma: A Comparison with Uterine Endometrial Adenocarcinoma.

Oncology — Thu, 09 Aug 2007 04:00:00 +0100

Conclusion: Our results demonstrate that the clinical behavior of carcinosarcoma strongly resembles that of G3 endometrial adenocarcinoma, setting it apart from other 'pure' uterine sarcomas. Copyright (c) 2006 S. Karger AG, Basel. PMID: 17690557 [PubMed - as supplied by publisher] (Source: Oncology)