MedWorm: Cardiac Sarcoma

Unusual presentation of multiple recurrent cardiac sarcomas as acute acalculous cholecystitis caused by rapid expansion into the right cardiac chamber: report of a case

Surgery Today — Tue, 22 Nov 2011 17:58:35 +0100

Abstract Sarcomas are rare malignant cardiac tumors and their prognosis is extremely poor, with a high recurrence rate despite extensive initial surgical resection. The development of therapeutic alternatives looks bleak for recurrent sarcomas, however, and complete surgical resection is crucial for any hope of survival even for the recurrent patients. We herein report the case of a 38-year-old male patient with multiple recurrent cardiac sarcomas causing acute acalculous cholecystitis 20 months after the resection of the primary tumor. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s00595-011-0022-7Authors Koji Takeda, Department of Cardiovascular Surgery, Sakurabashi Watanabe Hospital, 2-4-32 Kitaku, Umeda, Osaka, 530-0001 JapanTakafumi Ma...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Cardiac sarcomas: therapeutic options?

Future Cardiology — Mon, 19 Sep 2011 14:47:58 +0100

Future Cardiology , September 2011, Vol. 7, No. 5, Pages 595-597. (Source: Future Cardiology)

Pericardial synovial sarcoma of the heart; is it always worth operating?

The Journal of Cardiovascular Surgery — Thu, 15 Sep 2011 00:08:37 +0100

We report the case of a 37 year old male patient who presented with intermittent fever, nocturnal sweating and asthenia. Chest X-ray revealed an enlarged cardiac silhouette. Echocardiography identified pericardial effusion and a mass compressing the right ventricle. After percutaneous drainage of the effusion, the mass was not visible and deemed to have been septations of the effusion. Chest computed tomography (CT) did not show the mass visible on the X-ray. At one month follow-up, the pericardial mass was again visible on echocardiography and confirmed by magnetic resonance imaging (MRI). CT-guided biopsy showed malignant mesenchymal cells. Complete resection was attempted, but not possible due to diffuse infiltration of the epicardium. Histological examination of the resected tissue rev...

Primary cardiac sarcoma mimicking mural thrombus

European Journal of Echocardiography — Mon, 12 Sep 2011 04:00:00 +0100

(Source: European Journal of Echocardiography)

Primary cardiac synovial sarcoma —A case report—

General Thoracic and Cardiovascular Surgery — Wed, 13 Jul 2011 05:57:55 +0100

We report a case of cardiac synovial sarcoma, a very rare primary tumor of the heart. The patient was a 29-year-old man with chief complaint of dyspnea. On echocardiography, a tumor 42 mm in diameter occupying the most space of the left atrium was found. The tumor was obstructed the opening of the mitral valve. He was diagnosed with heart failure due to disturbance of the pulmonary venous return and hemodynamic mitral valve stenosis, and underwent surgery. The tumor was a 5-cm sphere originating in the left atrial posterior wall, and was covered with a sheath and solid. The atrial posterior wall was covered with a peel that appeared to be tumor tissue, and this tissue expanded toward the openings of the pulmonary veins bilaterally and the posterior cusp of the mitral vavle. The tumor...

Primary cardiac angiosarcoma treated by complete tumor resection with cardiac reconstruction

Heart and Lung — Sat, 30 Apr 2011 23:00:00 +0100

We report a case of right atrial angiosarcoma treated by complete tumor resection with cardiac reconstruction with a bovine pericardium patch. (Source: Heart and Lung)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Primary synovial sarcoma of the heart.

Cardiology Journal — Thu, 31 Mar 2011 16:30:04 +0100

We present a further case. This uncommon malignancy has no specific symptoms during its development, which results in delayed diagnosis. Echocardiography, chest computed tomography, and magnetic resonance imaging can provide effective information about this tumor. With the identification of the characteristic and diagnostic chromosomal abnormality t(X; 18), this malignancy will become increasingly recognized. Synovial sarcoma of the heart requires surgical intervention to improve the prognosis. Adjuvant and/or genetic therapy pre- or postoperation can help prolong life. Chemotherapy is usually recommended as it may benefit the patients. The key to treatment in the future is to find new therapeutic agents. Further elucidation of the effects of this chromosomal abnormality may lead to better...

Primary cardiac low grade sarcomas mimicking myxomas. Pitfall in diagnosis

Diagnostic Histopathology — Mon, 28 Feb 2011 00:00:00 +0100

Abstract: Cardiac sarcomas can resemble myxomas macroscopically and microscopically. These tumours can be easily misdiagnosed unless examined carefully. The presence of spindle cells with mitoses, hypercellular areas the formation of a cellular “cambium” layer beneath the surface and/or an unusual location of the tumour are often helpful in recognizing the true nature of these tumours. (Source: Diagnostic Histopathology)

Outcomes After Right-Side Heart Sarcoma Resection [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Wed, 23 Feb 2011 00:00:00 +0100

Conclusions The patients with right-side heart sarcoma resection had worse survival after resection than that reported for our patients who underwent resection for left-side heart sarcoma or pulmonary artery sarcoma. Because positive surgical margin status is an independent predictor of reduced survival, induction chemotherapy should considered to enhance resectability in right-side heart sarcoma patients, thus maximizing the possibility of obtaining negative surgical margins. (Source: The Annals of Thoracic Surgery)

A primary cardiac sarcoma presenting with superior vena cava obstruction

The American Journal of Emergency Medicine — Mon, 31 Jan 2011 05:00:00 +0100

We describe the case of a 48-year-old man who presented with dyspnea, confusion, and facial swelling with cyanosis. The patient developed life-threatening airway obstruction after administration of anxiolytic. The diagnosis of SVC obstruction secondary to a primary cardiac sarcoma was established based on clinical, radiologic, and post-mortem findings. This is one of very few reported cases of a primary cardiac sarcoma causing SVC obstruction. (Source: The American Journal of Emergency Medicine)

Primary left ventricular cardiac sarcoma.

Cardiology Journal — Thu, 23 Dec 2010 23:10:04 +0100

Authors: Aggeli C, Lampropoulos K, Kartalis A, Felekos J, Kazazaki C, Aggelis A, Dounis V, Pitsavos C, Stefanadis C PMID: 21154270 [PubMed - in process] (Source: Cardiology Journal)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Clinical and pathological features of high grade primary cardiac osteosarcoma [Case report - Thoracic oncologic]

Interactive CardioVascular and Thoracic Surgery — Tue, 21 Dec 2010 00:00:00 +0100

We report one case of primary cardiac osteosarcoma arising from the left atrium of a 42-year-old woman and analyze its clinical and pathological features. Histopathologic examination revealed the tumor was composed of massive osteoid and cartilaginous differentiation embedded in spindle and polygonal cells with marked cytological and nuclear pleomorphism. The patient was alive without recurrence or metastasis at 20 months after surgery without further adjuvant chemotherapy or radiotherapy. (Source: Interactive CardioVascular and Thoracic Surgery)

Primary right atrial sarcoma

Journal of Cancer Research and Therapeutics — Mon, 29 Nov 2010 00:00:00 +0100

Virendra Bhandari, Pramod Sakhi, Kavita Munjal, Amit V Varma, Rakesh Shishodiya, Vishal K JainJournal of Cancer Research and Therapeutics 2010 6(3):347-349Primary malignant tumors of heart are rare with unfavorable prognosis and are mostly diagnosed on autopsy. They have varied presentation and are difficult to diagnose. Most of the cases are benign and others are sarcomas. Here we present a case of primary cardiac sarcoma which had varied presentation and was undiagnosed due to non specific symptoms. Diagnosis of atrial tumor was confirmed on histopathological examination of tissue obtained after thoracotomy. Being inoperable, the patient was given palliative chemotherapy with which we could provide her a better quality of life. (Source: Journal of Cancer Research and Therapeutics)

Large primary cardiac sarcoma on the left ventricular free wall: is total excision contraindicated? [Case report - Cardiac general]

Interactive CardioVascular and Thoracic Surgery — Tue, 19 Oct 2010 23:00:00 +0100

In conclusion, an aggressive attempt at volume reduction such as cardiac autotransplantation may relieve the symptoms, even though such surgery would only be palliative. (Source: Interactive CardioVascular and Thoracic Surgery)

Cardiac Autotransplantation

Operative Techniques in Thoracic and Cardiovascular Surgery: A Comparative Atlas — Tue, 31 Aug 2010 05:10:09 +0100

Cardiac tumors are unusual and cardiac malignancy, usually sarcoma, is a very small subset of these. The literature on cardiac sarcomas of the left heart often exhibited multiple operations for local recurrence, which we believed was related to inadequate resection, likely exacerbated by poor anatomic exposure of the posterior heart for complex resection and reconstruction. Since November 1998, we have approached large complex sarcoma of the left atrium or left ventricle using the technique of cardiac explantation, ex vivo tumor resection, and cardiac reconstruction and reimplantation of the heart—cardiac autotransplantation. This allows complete exposure of left heart structures for aggressive resection and accurate reconstruction, permitting the removal if necessary of the entire left ...

Long-Term Survival With Heart Transplantation for Fibrosarcoma of the Heart.

The Annals of Thoracic Surgery — Sat, 31 Jul 2010 21:46:02 +0100

We report a case of a 25-year-old woman with sarcoma of the heart who received a transplant and is clinically well after 7 years. We believe that transplantation must be considered in this kind of pathology for selected cases. PMID: 20667366 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Primary cardiac undifferentiated sarcoma: role of intraoperative imprint cytology and frozen section of two cases

Cardiovascular Pathology — Thu, 29 Jul 2010 23:00:00 +0100

Abstract: Primary cardiac tumors are very rare, and a vast majority of such malignant tumors are sarcomas. Associated symptoms are usually vague and nonspecific resulting in a late diagnosis and poorer prognosis. Most cardiac sarcomas have been reported in autopsy series. Although echocardiography may help make a diagnosis of a cardiac sarcoma, histopathological confirmation is quintessential. Presented here are two cases of patients who underwent successful surgery for the removal of a cardiac tumor, along with echocardiographic, cytological, and histopathological findings as well as a compact literature review. In both patients, the masses were on the surface of the mitral valve, and intraoperative evaluation of frozen sections and imprint cytology were indicative of a “probably malign...

Long-Term Survival With Heart Transplantation for Fibrosarcoma of the Heart [CASE REPORTS]

The Annals of Thoracic Surgery — Tue, 27 Jul 2010 18:48:06 +0100

Primary Cardiac Sarcoma [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Tue, 29 Jun 2010 18:11:04 +0100

Conclusions Cardiac sarcomas are a distinct, rare subset of soft tissue sarcomas with a poor prognosis. Surgery continues to be the central component of successful management. Future clinical efforts should be directed at developing approaches to permit safe radical excision and, potentially, developing effective adjuvant therapy. (Source: The Annals of Thoracic Surgery)

Case report Cerebral metastasis of a primary heart sarcoma

Fri, 07 May 2010 13:13:12 +0100

Primary cardiac sarcomas are exceptionally rare tumours. A brain metastasis of a primary cardiac sarcoma has never been reported before. Although we know lots of primary malignomas spreading to the brain, we never observed cerebral metastases of an atrial spindle cell sarcoma. Cardiac sarcomas are more likely to haematogenously metastasize to the lung or the liver. Here, we describe the case of a young man, who suffered from a cerebral metastasis of a spindle cell sarcoma in the left heart atrium nine years ago. Postoperative whole brain irradiation with 30 Gy was performed. Later on, the patient experienced a local recurrence within the left atrium accompanied by cardiac arrhythmia and mitral valve insufficiency. This case is the very first description of a true cerebral metastasis from a...

Cardiac sarcoma presenting as heart failure and diagnosed as recurrent myxoma by echocardiogram

European Journal of Echocardiography — Fri, 30 Apr 2010 16:23:08 +0100

We report a case of an extremely rare high-grade, undifferentiated cardiac sarcoma. The patient with left atrial myxoma resected 8 months ago presented with pneumonia, congestive heart failure, and subsequently diagnosed to have cardiac sarcoma. Transoesophageal echocardiogram played an important role in diagnosis of left atrial mass. High index of suspicion is required to diagnose left atrial tumour as initially it can present as pneumonia or congestive heart failure and left atrial tumours are not always the myxoma. (Source: European Journal of Echocardiography)

MedWorm Sponsor Message: Find the best January Sales in the UK.

[Malignant primary cardiac tumors in childhood and adolescence.]

Archives de Pediatrie — Tue, 23 Mar 2010 00:00:00 +0100

We report here 3 observations of primary malignant cardiac tumors, 2 cases of sarcoma (angiosarcoma and synovial sarcoma) and 1 case of Burkitt's lymphoma. A precise pathological diagnosis is necessary for the proper management of these patients. For sarcoma, treatment associates surgery and chemotherapy. Surgery should be as complete as possible because of the lack of chemotherapy sensitivity of some sarcomas, mainly angiosarcoma and synovial sarcoma. Therefore, the prognosis of cardiac sarcoma remains poor. For primary cardiac lymphoma, management should not be different from lymphoma in other locations. Chemotherapy is the main treatment, and surgery has to be used only when complications occur. Prognosis depends on histology and not lymphoma location, and so is better than the prognosi...

Cerebral metastasis of a primary heart sarcoma.

Neurologia i Neurochirurgia Polska — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Kuhn SA, Walter J, Petersen I, Mueller U, Reichart R, Kalff R Primary cardiac sarcomas are exceptionally rare tumours. A brain metastasis of a primary cardiac sarcoma has never been reported before. Although we know lots of primary malignomas spreading to the brain, we never observed cerebral metastases of an atrial spindle cell sarcoma. Cardiac sarcomas are more likely to haematogenously metastasize to the lung or the liver. Here, we describe the case of a young man, who suffered from a cerebral metastasis of a spindle cell sarcoma in the left heart atrium nine years ago. Postoperative whole brain irradiation with 30 Gy was performed. Later on, the patient experienced a local recurrence within the left atrium accompanied by cardiac arrhythmia and mitral valve insufficiency. T...

Surgical treatment of primary cardiac sarcomas.

Texas Heart Institute Journal — Sat, 31 Oct 2009 12:32:03 +0100

Authors: Blackmon SH, Reardon MJ PMID: 19876427 [PubMed - in process] (Source: Texas Heart Institute Journal)

Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency Experience

Annals of Surgical Oncology — Thu, 15 Oct 2009 05:55:42 +0100

Conclusions Patients with nonmetastatic cardiac sarcoma amenable to complete resection experienced improved survival. However, the high overall rates of disease progression and mortality highlight the need for more effective local and systemic treatments that may be used in conjunction with surgery to improve patient outcomes. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0734-8Authors Pauline T. Truong, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaStuart O. Jones, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaBenjamin Martens, University of British Columbia Vancouver BC CanadaCheryl Alexander, British Columbia Cancer ...

Primary sarcoma of the right ventricle: surgical and adjuvant therapy

General Thoracic and Cardiovascular Surgery — Wed, 23 Sep 2009 05:51:11 +0100

We describe surgical and adjuvant therapeutic management of a right ventricular (RV) sarcoma and pulmonary artery occlusion. Echocardiographic evaluation of a 39-year-old man with exertional dyspnea revealed a tumor mass in the right ventricle, pulmonary trunk, and bilateral pulmonary arteries. The tumor was resected with concomitant pulmonary valvotomy, but the resection was incomplete. The RV outflow was reconstructed with an allograft patch, and a stentless valve was implanted for pulmonary valvular function. The pulmonary trunk and arteries were enlarged with allograft patches. The tumor was undifferentiated sarcoma and caused postoperative pulmonary artery restenosis. Radiotherapy improved pulmonary perfusion (reduction of RV pressure), but the patient died of brain metastasis. ...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Delayed left ventricular free-wall rupture after cardiac sarcoma resection.

Texas Heart Institute Journal — Sat, 27 Jun 2009 15:04:03 +0100

We report the case of a 38-year-old woman who underwent cardiac sarcoma resection and presented later with spontaneous left ventricular free-wall rupture. The original tumor resection required autotransplantation and a transmitral approach, including partial resection of the inner left ventricular wall. Although the patient did well postoperatively, 3 weeks later she developed a large pericardial effusion with tamponade. Intraoperatively, a portion of the left ventricular free wall ruptured and required repair with a Dacron patch. The patient recovered and was discharged from the hospital 3 weeks later. To our knowledge, this is the 1st reported case of spontaneous ventricular rupture after the resection of a cardiac tumor. PMID: 19436818 [PubMed - in process] (Source: Texas Heart Inst...

Imprint cytology of primary cardiac sarcomas: a report of 3 cases

Annals of Diagnostic Pathology — Thu, 21 May 2009 23:00:00 +0100

This study elucidated the cellular characteristics and immunohistochemistry for cardiac sarcomas using imprint smears as an aid to cytopathologic diagnosis. (Source: Annals of Diagnostic Pathology)

[Case report - Cardiac general] Prolonged survival with left atrial spindle cell sarcoma

Interactive CardioVascular and Thoracic Surgery — Thu, 14 May 2009 04:00:00 +0100

This report describes a 48-year-old gentleman who underwent multiple surgeries to achieve an 11-year survival since the diagnosis. The operative techniques have been described. (Source: Interactive CardioVascular and Thoracic Surgery)

Prolonged survival with left atrial spindle cell sarcoma [Case report - Cardiac general]

Interactive CardioVascular and Thoracic Surgery — Wed, 13 May 2009 23:00:00 +0100

Primary cardiac sarcoma presenting as shock

Indian Journal of Thoracic and Cardiovascular Surgery — Sat, 25 Apr 2009 07:23:07 +0100

We report an adult male who presented to emergency department with shock. Echocardiography revealed a huge right ventricular mass obstructing the right ventricular outflow tract and he underwent emergency resection of the mass. Subsequent histopathology confirmed the diagnosis of fibromyxosarcoma. Primary cardiac sarcoma presenting as circulatory shock is a rare phenomenon. Content Type Journal ArticleDOI 10.1007/s12055-009-0008-xAuthors Rangaraj Ramalingam, Sri Jayadeva Institute of Cardiology Department of Cardiology Bangalore 560069 IndiaNagaraja Moorthy, Sri Jayadeva Institute of Cardiology Department of Cardiology Bangalore 560069 IndiaVenugopal Ram Rao, Sri Jayadeva Institute of Cardiology Department of Cardiothoracic and Vascular Surgery Bangalore 560069 IndiaManjunath Chole...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Outcomes after surgical resection of cardiac sarcoma in the multimodality treatment era

The Journal of Thoracic and Cardiovascular Surgery — Thu, 02 Apr 2009 23:00:00 +0100

Conclusions: Multimodal therapy can achieve reasonable survival for patients with resected cardiac sarcomas. Patients with local tumor recurrence or metastatic disease may still benefit from aggressive treatment. (Source: The Journal of Thoracic and Cardiovascular Surgery)

An Uncommon Cause of Heart Failure: Cardiac Sarcomas in the Left Atrium

The Journal of Emergency Medicine — Mon, 09 Mar 2009 00:00:00 +0100

A 26-year-old woman presented to our emergency department (ED) with 2 days of progressive dyspnea. The patient presented with general soreness and a productive cough with sputum 1 week before the ED visit. She became febrile 5 days later. The patient was alert and responsive on ED presentation, with an initial temperature of 35.3°C, a heart rate of 117 beats/min, a respiratory rate of 28 breaths/min, a blood pressure of 116/74 mm Hg, and an oxygen saturation of 90% with a 100% non-rebreathing mask. Physical examination revealed engorged jugular veins, bilateral basal crackles over lung fields, muffled heart sounds, and bilateral pitting edema of the lower legs. Pink frothy sputum was also noted. Laboratory tests revealed a white blood cell count of 27,600/mm3, with 85% segmented neutrophi...

Primary cardiac undifferentiated sarcoma of the right atrium presenting with cardiac tamponade

Cardiovascular Pathology — Sun, 01 Mar 2009 05:00:00 +0100

This report illustrates the serial imaging of a primary cardiac undifferentiated sarcoma of the right atrium using echocardiography, chest X-ray, and computed tomography. Transthoracic echocardiography on presentation showed an extensive mass of the right atrial free wall with an impending cardiac tamponade. Symptoms were controlled with pericardiocentesis, pericardial window, and radiotherapy but recurred 8 months later with pleural effusion and tumor spread to the great arteries. Primary cardiac sarcoma (PSC) is a rare and aggressive malignancy that is usually diagnosed late due to its nonspecific symptoms. Cytology and cardiac biopsy may be negative, and suspicion for the tumor is warranted in recurrent pericardial effusion. Analogous to parietal pleural biopsy in lung tumors with pleur...

An unusual case of spinal column metastasis after orthotopic transplantation for cardiac sarcoma.

Journal of Neurosurgery.Spine — Wed, 01 Oct 2008 04:00:00 +0100

Authors: McLoughlin GS, Sciubba DM, Ali SK, Weinkauf JG, Fourney DR The authors describe a patient who underwent orthotopic cardiac transplantation after an undifferentiated cardiac sarcoma was diagnosed. While receiving immunosuppressive therapy, the patient developed spinal column metastases and cauda equina syndrome requiring surgical decompression and stabilization. This occurred despite an exhaustive search for metastatic disease prior to the transplantation. To the authors' knowledge, this represents the first reported case of an undifferentiated cardiac sarcoma metastasis to the spine. This previously healthy 18-year-old woman presented with a myocardial infarction. Investigations revealed a left atrial tumor, which was resected. Following local recurrence, the patient underwent...

Stereotactic radiosurgery for a cardiac sarcoma: a case report.

Technology in Cancer Research and Treatment — Sat, 13 Sep 2008 12:03:36 +0100

We report a case of a 75-year-old man with a pulmonary artery sarcoma, recurrent following surgical resection. To palliate symptoms of this recurrence, he underwent CyberKnife stereotactic radiosurgery with a clinical and radiographic response of his treated disease. No acute or sub-acute toxicity was seen until the patient's death due to metastatic disease 10 weeks following treatment. The feasibility and short-term safety of this technique are reviewed, with emphasis on the stereotactic planning considerations, such as mediastinal organ movement and radiation tolerance. PMID: 18783285 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival.

Human Pathology — Thu, 03 Jul 2008 04:00:00 +0100

Authors: Zhang PJ, Brooks JS, Goldblum JR, Yoder B, Seethala R, Pawel B, Gorman JH, Gorman RC, Huang JH, Acker M, Narula N Although cardiac sarcomas are rare in comparison to their soft tissue counterparts, they are the second most common type of primary cardiac neoplasm. Of the few hundred cases reported, most has been based on autopsy series. A series of 27 cardiac sarcomas removed at surgery for curative and diagnostic intent were reviewed for clinicopathologic features with correlation to available postoperative follow-up data in 17 patients. There were 6 angiosarcomas, 6 myxofibrosarcomas, 3 malignant peripheral nerve sheath tumors, 3 leiomyosarcomas, 2 synovial sarcomas, 1 epithelioid hemangioendothelioma, 1 chondrosarcoma, 1 osteosarcoma, and 4 poorly differentiated sarcomas. Th...

Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience.

Human Pathology — Sun, 01 Jun 2008 04:00:00 +0100

In conclusion, angiosarcoma and unclassified sarcomas are the most common sarcomas of the heart accounting for 76%, but rare tumors such as synovial sarcoma and leiomyosarcoma may also occur in this organ. The survival of cardiac sarcomas is poor. PMID: 18538171 [PubMed - in process] (Source: Human Pathology)

Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy.

International Journal of Hematology — Sat, 24 May 2008 04:00:00 +0100

Authors: Koželj M, Zorman D, Mrevlje B, Cernelč P, Zver S A 52-year-old man presented with clinical and echocardiographic signs of cardiac tamponade. A transthoracic echocardiogram revealed a large right atrial mass that obstructed the superior vena cava flow. Cardiac magnetic resonance imaging and computed tomography demonstrated extracardiac tumour invasion of the free atrial wall extending to the right pulmonary hilus. Intracardiac echocardiography-guided biopsy of the tumour revealed the tissue diagnosis-granulocytic sarcoma of the heart. The patient was effectively treated with radiotherapy, chemotherapy and allogeneic haematopoietic stem cell transplantation. He has remained free of the disease for 12 months after treatment. PMID: 18498027 [PubMed - as supplied by...

Isolated Left-Sided Metastatic Sarcoma of the Heart with Limb Ischemia. A Case Report

JBJS [Am] — Thu, 01 May 2008 04:00:00 +0100

(Source: JBJS [Am])

Isolated left-sided metastatic sarcoma of the heart with limb ischemia. A case report.

The Journal of Bone and Joint Surgery. American volume — Thu, 01 May 2008 04:00:00 +0100

Authors: Maheshwari AV, Muro-Cacho CA, Cohen JJ, Keisch M, Klos RB, Temple HT PMID: 18451405 [PubMed - indexed for MEDLINE] (Source: The Journal of Bone and Joint Surgery. American volume)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Malignant primary cardiac tumors

Cancer — Mon, 21 Apr 2008 04:00:00 +0100

Primary cardiac sarcomas are uncommon. The authors undertook to review the Mayo Clinic's experience with primary cardiac sarcomas consisting of 34 patients seen over a 32-year period.The patient database at the Mayo Clinic was searched to identify patients with malignant tumors of the heart seen during the 32-year period between 1975 and 2007. Thirty-four patients with primary cardiac sarcomas were identified and their medical records reviewed for details pertaining to presenting symptoms, staging modalities, treatment approaches, and outcomes.Of the 34 patients, 17 were men and 17 were women. The median age was 44 years. The mean duration of symptoms at the time of diagnosis was 3.6 months. The most common histologic type was angiosarcoma (41%). The median follow-up for the entire group w...

Primary cardiac sarcoma.

Indian Journal of Pathology and Microbiology — Tue, 01 Jan 2008 05:00:00 +0100

Authors: Khadilkar UN, Harish R, Tantry G, Kumar S, Tiwari A Primary cardiac sarcomas are uncommon entities. The diagnosis of sarcoma is not made preoperatively because of the rarity of the lesion and the nonspecific nature of the signs and symptoms. This is a report of a case of primary sarcoma arising from the left atrium, in a patient who presented with acute dyspnoea; the sarcoma resembled an atrial myxoma on echocardiography. PMID: 18417846 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Low-grade myofibroblastic sarcoma of the heart causing sudden death.

Cardiovascular Pathology — Sat, 29 Dec 2007 01:54:24 +0100

We present a case of a primary cardiac sarcoma presenting as sudden death in a 5-year-old Asian girl. Pathologic examination of the lesion confirmed that this was an atypical myofibroblastic neoplasm, consistent with a low-grade sarcoma. Pediatric cardiac sarcomas are rare in general, and this is the first reported case of a valvular low-grade myofibroblastic sarcoma presenting in a child. PMID: 18160061 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology)

Primary cardiac sarcoma: reports of two cases and a review of current literature

Journal of Cardiothoracic Surgery — Tue, 24 Jul 2007 04:00:00 +0100

We report the cases of two patients presenting with features of obstruction and embolism and a presumed diagnosis of left atrial myxoma. At operation they were unexpectedly found to have large tumours raising strong suspicions of malignancy. Due to the extensive involvement of intracardiac structures with little possibility of reconstruction together with poor general condition of the patient, debulking was deemed to be the only viable option. Subsequent histology confirmed the diagnosis of sarcoma in both patients. Surgery produced immediate and effective symptom relief. The first patient died four months after the operation and second patient is still alive at 12 months after her operation. A brief review of literature on cardiac sarcoma is presented. (Source: Journal of Cardiothoracic S...

[CASE STUDIES] Intimal Cardiac Sarcoma in a Pregnant Woman

Asian Cardiovascular and Thoracic Annals — Tue, 23 Jan 2007 07:00:00 +0100

A 29-year-old female patient in the 28th week of pregnancy was diagnosed with a cardiac tumor. We performed tumor excision and mitral valve replacement, and her baby was born successfully with cesarean section on the 9th day after cardiac surgery. After this event, 8 cycles of chemotherapy were administered. After 10 months, metastatic intimal sarcoma of the right ovary developed, and a right salpingo-oophorectomy and omentectomy was performed. However, the patient died of sudden onset of intractable ventricular fibrillation. (Source: Asian Cardiovascular and Thoracic Annals)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Cardiac autotransplantation for surgical resection of a primary malignant left ventricular tumor.

Texas Heart Institute Journal — Fri, 12 Jan 2007 23:33:02 +0100

We report the case of a patient who had a large, primary, intracavitary, left ventricular sarcoma that was successfully removed by cardiac explantation and ex vivo reconstruction with use of the cardiac autotransplantation technique. This is the 1st report describing the use of cardiac autotransplantation to surgically resect an intracavitary left ventricular malignancy. PMID: 17215979 [PubMed - in process] (Source: Texas Heart Institute Journal)

[LETTERS TO THE EDITOR] Survival after radical resection of cardiac sarcomas

European Journal of Cardio-Thoracic Surgery — Fri, 01 Dec 2006 07:00:00 +0100

(Source: European Journal of Cardio-Thoracic Surgery)

Primary cardiac sarcoma in pregnancy: a case report.

J Korean Med Sci — Thu, 19 Oct 2006 05:21:03 +0100

We report a pregnant woman at 27(+5) weeks gestation who was admitted to the hospital with acute-onset dyspnea. A mass was found on the left atrium by transthoracic echocardiography. Subsequently, the intracardiac mass was removed, and mitral valve replacement and modified DeVega tricuspid annuloplasty were performed. The patient was diagnosed with a undifferentiated sarcoma, and gave birth to a 1,230 g living baby boy by Caesarean section from preterm contraction at 29(+5) weeks gestation. The patient then received systemic chemotherapy. However, 10 months after the initial clinical onset, the patient suddenly died. Surgery is the standard treatment for cardiac tumors, and their removal should always be attempted, even in pregnant women. Although the overall survival rates of the patients...

[CASE STUDIES] Malignant Peripheral Nerve Sheath Tumor of the Heart

Asian Cardiovascular and Thoracic Annals — Wed, 27 Sep 2006 06:00:00 +0100

A 32-year-old man presented with dyspnea, chest pain, palpitations and ankle edema and was found to have a tumor involving the heart. This was diagnosed as malignant peripheral nerve sheath tumor, a rare sarcoma of the heart. Immunohistochemistry was utilized to establish the diagnosis. The details of the patient’s clinical course, and imaging findings with morphological and immunohistochemistry data are reported. (Source: Asian Cardiovascular and Thoracic Annals)

[REVIEW PAPER] Primary Left Atrial Leiomyosarcoma: Literature Review and Lessons of a Case

Asian Cardiovascular and Thoracic Annals — Wed, 27 Sep 2006 06:00:00 +0100

Primary cardiac sarcoma is an uncommon disease. In particular, leiomyosarcoma of cardiovascular origin is extremely rare. Half of all cardiac leiomyosarcomas are located in the left atrium. Due to the extreme rarity of left atrial leiomyosarcoma, there is no great experience in its management. This review includes a report of a case of left atrial leiomyosarcoma followed up over 45 months. The literature review examines the distribution of left atrial leiomyosarcoma, the physiological reasons for the tendency of cardiac leiomyosarcoma to be localized to the left atrial cavity, the clinical and physical appearance of this disease, and the key differences between left atrial leiomyosarcoma and the most common left atrial tumor, myxoma. The morphological features, using light and electron mic...

MedWorm Sponsor Message: Find the best January Sales in the UK.

[REVIEWS] Primary cardiac sarcoma

European Journal of Cardio-Thoracic Surgery — Fri, 26 May 2006 06:00:00 +0100

This article addresses these issues, deals with the surgically relevant modes of presentation, rather than the histopathology, and reviews the diagnosis and management options for the various sarcomas, categorized by the site and extent of cardiac involvement. Clinicians should be familiar with the presentation of these tumours and have a high index of suspicion, since the potential for long-term survival following resection does exist. Wide surgical resection remains the cornerstone of sarcoma therapy. Complete characterization of tumour extent using echocardiography and CT/MRI is mandatory to achieve this goal. Radical resections such as ‘bench surgery’ and transplantation may reduce local recurrence, but the risk of metastatic disease remains. The clinical experience with su...

Primary synovial sarcoma of the mitral valve.

Cardiovascular Pathology — Tue, 01 Nov 2005 05:00:00 +0100

Authors: Miller DV, Deb A, Edwards WD, Zehr KJ, Oliveira AM Primary cardiac synovial sarcoma is a rare malignancy, comprising approximately 5% of cardiac sarcomas and less than 0.1% of all primary cardiac tumors. Herein, we describe a synovial sarcoma arising on the anterior mitral leaflet in a 66-year-old man. The histopathologic diagnosis was supported by the immunohistochemical profile and the presence of the SYT-SSX1 fusion transcript identified by molecular genetic studies. PMID: 16286044 [PubMed - indexed for MEDLINE] (Source: Cardiovascular Pathology)