MedWorm: Cervical Cancer

Potactasol 4mg powder for concentrate for solution for infusion (topotecan)- New Product

NeLM - SPC Changes — Wed, 08 Feb 2012 05:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Actavis has launched Potactasol 4mg powder for concentrate for solution for infusion (topotecan). Topotecan monotherapy is indicated for the treatment of patients with metastatic carcinoma of the ovary after failure of first-line or subsequent therapy and patients with relapsed small cell lung cancer (SCLC) for whom re-treatment with the first-line regimen is not considered appropriate. It can be used in combination with cisplatin for patients with carcinoma of the cervix recurrent after radiotherapy and for patients with Stage IVB disease. Please refer to the link below for the New SPC for new product Potactasol powder for concentrate for solution for infusion. (S...

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Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

BioMed Central — Wed, 08 Feb 2012 05:00:00 +0100

Conclusions: Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells. (Source: BioMed Central)

Self-Collection and HPV DNA Testing Could Be an Effective Cervical Cancer Screening Method

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Is It Time to Introduce HPV Self-Sampling for Primary Cervical Cancer Screening?

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Pooled Analysis of a Self-Sampling HPV DNA Test as a Cervical Cancer Primary Screening Method

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions The sensitivity of Self-HPV testing compared favorably with that of LBC and was superior to the sensitivity of VIA. Self-HPV testing may complement current screening programs by increasing population coverage in settings that do not have easy access to comprehensive cytology-based screening. (Source: JNCI)

Cytotoxic Triterpenoid Saponins from Ardisia gigantifolia

Planta Medica — Tue, 07 Feb 2012 05:00:00 +0100

Planta MedDOI: 10.1055/s-0031-1298254AbstractThree new triterpenoid saponins, 1–3, together with two known saponins, 4 and 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were elucidated by 1D and 2D NMR spectroscopic studies. Saponins 1, 2, 4, and 5 exhibited significant cytotoxicity against four human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, HepG-2 human hepatoma cells, and BCG human gastric carcinoma cells with IC50 values in the range of 1.9–4.8 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Planta Medica)

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Rural-Urban Trends and Patterns in Cervical CancerRural-Urban Trends and Patterns in Cervical Cancer

Medscape Today Headlines — Tue, 07 Feb 2012 04:00:00 +0100

Does place of residence, whether it's rural or urban, have any effect on whether a woman may develop cervical cancer in her lifetime? This new study looks at almost a half century of data in the US. Journal of Community Health (Source: Medscape Today Headlines)

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Mon, 06 Feb 2012 11:59:14 +0100

UNITED NATIONS, New York—UNFPA has joined Tokyo FM Radio and other Japanese partners, including the Japanese Ministry of Health, Labour and Welfare; Sanrio, maker of the popular 'Hello Kitty' doll; UNIQLO, the global clothing company; and Japan Airlines in the Hellosmile Project—a worldwide effort to prevent cervical cancer. (Source: UNFPA News)

In latest vaccine marketing fraud, CDC says Gardasil shots should be 'routine' for boys

NaturalNews.com — Mon, 06 Feb 2012 06:00:00 +0100

Every male between the ages of 11 and 21 should get a Gardasil vaccine for cervical cancer, and those between the ages of 13 and 21 should also get "catch-up" shots later down the road. This is only the opinion of the U.S. Centers for Disease Control and Prevention's... (Source: NaturalNews.com)

US Pediatricians Recommend Routine HPV Vaccination For Boys

Health News from Medical News Today — Fri, 03 Feb 2012 20:00:00 +0100

As part of a revised standard published this week, the American Academy of Pediatrics says boys should be routinely vaccinated against the human papillomavirus (HPV), a common virus that is spread through sexual contact. Although there are dozens of types of HPV, vaccines can protect both male and females against some of the more common types that can lead to disease and cancer... (Source: Health News from Medical News Today)

Highest-ever levels of multi-drug-resistant TB revealed | Sarah Boseley

Guardian Unlimited Science — Fri, 03 Feb 2012 17:50:00 +0100

This study ought to give further impetus to the drive to find them.TB is an area that I know the IHME will be addressing before long, as part of its project, which has taken five years of work so far, to get the best possible handle on global mortality rates from all causes. They have tackled maternal mortality – their study showed it was lower than thought at a third of a million rather than half a million a year – and given us the first global data on breast and cervical cancer. Since their director Christopher Murray has been studying TB for 30 years, expect some interesting data from that quarter at some point.The WHO report is not (necessarily) about deaths, but they are up against the same problems as IHME – the absence of good data or, in some countries, any data.But a lot of ...

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UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Fri, 03 Feb 2012 12:20:46 +0100

Socioeconomic disparities in the uptake of breast and cervical cancer screening in Italy: a cross sectional study.

BMC Public Health - Latest articles — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions: Inequalities in the uptake of female screening widely exist in Italy. Organized screening programs may have an important role in increasing screening attendance and tackling inequalities. (Source: BMC Public Health - Latest articles)

Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy

BJOG: An International Journal of Obstetrics and Gynaecology — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

Malaria kills twice as many people as previously thought, research finds

Guardian Unlimited Science — Fri, 03 Feb 2012 00:41:00 +0100

Malaria kills 1.2 million people every year, a finding that has implications for global efforts to eliminate the diseaseMalaria kills twice as many people every year as formerly believed, taking 1.2 million lives and causing the deaths not only of babies but also older children and adults, according to research that overturns decades of assumptions about one of the world's most lethal diseases.The findings from the research, published on Friday, which has reanalysed 30 years of data on the disease using new techniques, will force a rethink of the huge global effort that has been under way to eliminate malaria. That ambition now looks highly unlikely by the UN target date of 2015.It also raises urgent questions about the future of the troubled Global Fund to Fight Aids, TB and Malaria, whic...

Assessing the Effectiveness of a Community-Based Sensitization Strategy in Creating Awareness About HPV, Cervical Cancer and HPV Vaccine Among Parents in North West Cameroon

Journal of Community Health — Thu, 02 Feb 2012 18:14:03 +0100

Abstract In 2010, the Cameroon Baptist Convention Health Services (CBCHS) received a donation of HPV vaccine (Gardasil®) to immunize girls of ages 9–13 years in the North West Region of Cameroon. We evaluated the effectiveness of the CBCHS campaign program in sensitizing parents/guardians to encourage HPV vaccine uptake, identified factors that influence parents’ decisions to vaccinate girls, and examined the uptake of cervical cancer screening among mothers. We conducted a cross-sectional survey in four healthcare facilities run by CBCHS, churches and other social settings. A total of 350 questionnaires were distributed and 317 were used for the analysis. There were high levels of awareness about cervical cancer, HPV and HPV vaccine. 75.5% understood HPV is sexua...

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Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

Cancer Immunology, Immunotherapy — Thu, 02 Feb 2012 17:58:29 +0100

In this study, we investigated the immunoregulatory role of IL-1β in the production of soluble MICA of HCC cells. First, we investigated the correlation between the serum IL-1β levels and soluble MICA in CH patients. Serum IL-1β levels were associated with soluble MICA levels in CH patients. The serum IL-1β levels of CH patients with the HCC occurrence were significantly higher than those of CH patients without HCC. We next examined the MICA production of IL-1β-treated HCC cells. Addition of IL-1β resulted in significant increase in the production of soluble MICA in HepG2 and PLC/PRF/5 cells, human HCC cells. But soluble MICA was not detected in both non-treated and IL-1β-treated normal hepatocytes. Addition of IL-1β did not increase the expressions of membrane-bound MICA on ...

Cervical cancer: There's an app for that

USATODAY.com Health — Thu, 02 Feb 2012 14:47:34 +0100

A novel Facebook app is being used to raise awareness about cervical cancer and ways to possibly avoid it, such as screening and vaccination ... (Source: USATODAY.com Health)

Recommendations For HPV And Hepatitis B Vaccinations Broadened By 2012 Adult Immunization Schedule

Health News from Medical News Today — Thu, 02 Feb 2012 09:00:00 +0100

The CDC's Advisory Committee on Immunization Practices (ACIP) now recommends routine HPV vaccination for males aged 11 to 12 years and catch-up vaccination for males aged 13 to 21. These are just two of the changes to the 2012 Recommended Adult Immunization Schedule published February 1 in Annals of Internal Medicine, the flagship journal of the American College of Physicians (ACP). In addition to the changes in the HPV vaccine, the ACIP now recommends vaccination against Hepatitis B for adults younger than age 60 who have diabetes, as soon as possible after diabetes is diagnosed... (Source: Health News from Medical News Today)

Predictive index for lymph node management of major salivary gland cancer

The Laryngoscope — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions:A predictive index using the clinicopathologic factors described in this report can effectively stratify patients into risk groups for nodal metastasis. Comprehensive management based on this risk index should improve treatment outcomes for patients with salivary gland cancer. (Source: The Laryngoscope)

Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis.

Molecular Biology Reports — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Sergentanis TN, Economopoulos KP, Choussein S, Vlahos NF Abstract This meta-analysis aims to examine whether the genotype status of MspI and Ile462Val polymorphisms in Cytochrome-P450 1A1 (CYP1A1) is associated with cervical cancer risk. Eligible case-control studies were identified through search in MEDLINE (end of search: October 2010). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random effects models. Concerning MspI polymorphism, six studies were eligible (722 cases and 770 controls); four studies were eligible (350 cases and 519 controls) for Ile462Val. MspI polymorphism was associated with elevated cervical cancer risk (for heterozygous TC vs. TT carriers OR = 1.50, 95% CI: 0.93-2.42, random effects; for homozygous CC vs. TT carriers O...

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A successful rescue with extra-anatomical bypass for massive bleeding of the brachiocephalic artery following salvage pharyngo-esophagectomy

Esophagus — Tue, 31 Jan 2012 07:07:17 +0100

Abstract Massive bleeding from large vessels is a serious and life-threatening complication after radical esophagectomy. Here, we present the rare case of patient survival following two episodes of massive bleeding from a tracheo-brachiocephalic artery fistula after salvage surgery for cervical esophageal cancer following definitive chemoradiation. During the first episode of bleeding, the damaged part of the brachiocephalic artery was transected with an extra-anatomical arterial bypass (right femoro-axillo artery bypass graft) to maintain the arterial blood flow to the brain and the free jejunal graft. During the second bleeding, the distal stump of the brachiocephalic artery was reclosed. During both episodes of bleeding, the musculocutaneous flap was effectively employe...

Cancer mortality‐to‐incidence ratios in Georgia

Cancer — Tue, 31 Jan 2012 05:00:00 +0100

CONCLUSIONS:More fatal cancers, particularly prostate, cervical, and oral cancer in men were detected among blacks, especially in central Georgia, where health behavior and social/economic factors were worse. MIRs are an efficient indicator of survival and provide insight into racial cancer disparities. Additional examination of geographic determinants of cancer fatality in Georgia as indicated by MIRs is warranted. Cancer 2012. © 2012 American Cancer Society (Source: Cancer)

The psychological impact of anal cancer screening on HIV‐infected men

Psycho-Oncology — Tue, 31 Jan 2012 05:00:00 +0100

ConclusionsAnal cancer specific worry increases throughout the screening process. Clear communication prior to procedures about the procedure itself, potential adverse events, the recovery process and non‐technical explanations of results should be implemented in anal screening programmes.Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Ten cases of gastro‐tracheobronchial fistula: a serious complication after esophagectomy and reconstruction using posterior mediastinal gastric tube

Diseases of the Esophagus — Tue, 31 Jan 2012 05:00:00 +0100

SUMMARYGastro‐tracheobronchial fistula (GTF) is a rare but life‐threatening complication specifically observed after esophagectomy and reconstruction using posterior mediastinal gastric tube. Ten cases of GTF were encountered in three hospitals in 2000–2009. Their clinicopathological, surgical, and postoperative care are summarized, together with a review of previously reported cases. GTF was classified as anastomotic leakage (n= 5), gastric necrosis (n= 4), and gastric ulcer type (n= 1). The anastomotic leakage type appeared about 2 weeks (postoperative day [POD]: 8–35) after esophagectomy, was located in the cervical or higher thoracic trachea. Breathing and pneumonia were controlled by tracheal tube placed in the distal of fistula. The gastric necrosis type was noted in patients...

Benefits of Male Circumcision [Letters]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

(Source: JAMA)

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Benefits of Male Circumcision--Reply [Letters]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

(Source: JAMA)

QnAs with Harald zur Hausen [QnAs]

Proceedings of the National Academy of Sciences — Tue, 31 Jan 2012 05:00:00 +0100

The first carcinogenic virus was discovered in chickens in 1911. More than 70 years later, Harald zur Hausen demonstrated that human papillomavirus (HPV) can cause cervical cancer, for which he garnered the 2008 Nobel Prize in Medicine or Physiology. A professor emeritus at the German Cancer Research Center and recently elected member of the National Academy of Sciences, zur Hausen’s contributions to the field of virology have reshaped our understanding of the connections between infectious and chronic diseases. PNAS recently spoke with the Nobel laureate about HPV, undercooked beef, and scientific “dogma.”pnas;109/5/1378/UNFIG01F1unfig01Harald zur Hausen.PNAS:In general, how do viruses cause cancer?zur... (Source: Proceedings of the National Academy of Sciences)

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State of the Fight: Cervical Cancer

Stand Up 2 Cancer — Mon, 30 Jan 2012 22:10:36 +0100

Cervical cancer is a malignant tumor that develops in the cervix - the part of the uterus that extends into the vaginal tract. Worldwide, cervical cancer is the third deadliest form of cancer among women. There are about one-half million new cases per year, and, globally, more than 50 percent of women who get cervical cancer die from it. More than 80 percent of deaths caused by cervical cancer occur in under-developed countries. read more (Source: Stand Up 2 Cancer)

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Mon, 30 Jan 2012 15:37:09 +0100

'Oral cancer risk' in men as HPV rates higher

NHS News Feed — Mon, 30 Jan 2012 09:57:00 +0100

Conclusion This was a relatively large cross-sectional study that estimated the number of oral HPV infections in the US among 14 to 69 year olds. These estimates cannot be directly generalised to the UK. The researchers say that their data provide evidence that oral HPV infection is mainly sexually transmitted. This is because infection was uncommon among participants with no previous sexual partners, but was up to eight times higher among those with previous partners, and increased significantly as the number of partners increased. The researchers do point out, however, that their study did not collect information on possible non-sexual transmission methods. While policy decisions regarding HPV infection generally focus on genital HPV among females, this research demonstrated that, at lea...

Glucocorticoid regulation of a novel HPV E6‐p53‐miR‐145 pathway modulates invasion and therapy resistance of cervical cancer cells

The Journal of Pathology — Mon, 30 Jan 2012 06:38:06 +0100

AbstractGlucocorticoids are stress‐responsive neuroendocrine mediators and play an important role in malignant progression, especially in solid tumors. We demonstrate a novel mechanism by which glucocorticoids modulate p53‐dependent miR‐145 expression in HPV positive cervical cancer cells through induction of E6 proteins. We found that expression of miR‐145 was reduced in cervical cancer tissues. Cortisol induced HPV E6 expression and suppressed p53 and miR‐145 in cervical cancer cells. MiR‐145 expression in cervical cancer cells was wild‐type p53‐dependent, and cortisol‐induced downregulation of miR‐145 expression prevented chemotherapy‐induced apoptosis whereas overexpression of miR‐145 enhanced sensitivity to mitomycin and reversed the chemoresistance induced by ...

Pretreatment carcinoembryonic antigen level is a risk factor for para-aortic lymph node recurrence in addition to squamous cell carcinoma antigen following definitive concurrent chemoradiotherapy for squamous cell carcinoma of the uterine cervix

Radiation Oncology — Mon, 30 Jan 2012 05:00:00 +0100

Background: To identify pretreatment carcinoembryonic antigen (CEA) levels as a risk factor for para-aortic lymph node (PALN) recurrence following concurrent chemoradiotherapy (CCRT) for cervical cancer. Methods: From March 1995 to January 2008, 188 patients with squamous cell carcinoma (SCC) of the uterine cervix were analyzed retrospectively. No patient received PALN irradiation as the initial treatment. CEA and squamous cell carcinoma antigen (SCC-Ag) were measured before and after radiotherapy. PALN recurrence was detected by computer tomography (CT) scans. We analyzed the actuarial rates of PALN recurrence by using Kaplan-Meier curves. Multivariate analyses were carried out with Cox regression models. We stratified the risk groups based on the hazard ratios (HR). Results: Both pretrea...

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Knowledge, attitude and practice in primary and secondary cervical cancer prevention among young adult Italian women.

Vaccine — Mon, 30 Jan 2012 05:00:00 +0100

Authors: Donati S, Giambi C, Declich S, Salmaso S, Filia A, Atti ML, Alibrandi MP, Brezzi S, Carozzi F, Collina N, Franchi D, Lattanzi A, Meda M, Minna MC, Nannini R, Gallicchio G, Bella A, Abstract In Italy since 2007 vaccination against human papillomavirus (HPV) is offered to 11-year-old females, whereas vaccination for older age groups is still a matter of debate. To assess Italian young women's knowledge, attitudes and practice regarding primary and secondary cervical cancer prevention a cross-sectional study among young women aged 18-26 years was conducted in 2008. The survey collected information on in-depth awareness and knowledge regarding Pap testing, HPV infection, HPV vaccine and cervical cancer. The response rate was 57.7% with a wide range of variability (34-84%) amo...

HPV Vaccine Not Linked To Autoimmune Disorders, Study

Health News from Medical News Today — Sun, 29 Jan 2012 00:00:00 +0100

A two-year study of nearly 190,000 girls and women, finds that Gardasil, the human papillomavirus (HPV) vaccine made by Merck & Co, does not trigger autoimmune disorders such as lupus, rheumatoid arthritis, type 1 diabetes and multiple sclerosis. The results are published in the Journal of Internal Medicine. Study lead author Dr Chun Chao, a research scientist at the Kaiser Permanente Department of Research & Evaluation in Pasadena, California, said in a statement released on Friday, that: "This kind of safety information may help parents with vaccination decisions... (Source: Health News from Medical News Today)

Too Few Americans Getting Screened for Common Cancers: CDC

Cancercompass News: Breast Cancer — Sun, 29 Jan 2012 00:00:00 +0100

National targets for breast, cervical and colon malignancies still not being met (Source: Cancercompass News: Breast Cancer)

Patterns of care for brachytherapy in Europe: updated results for Spain

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:15 +0100

Conclusion The three most common treatment sites (gynaecological, breast and prostate) remain unchanged from 2002, with prostate treatments showing large increase. Advanced dosimetric techniques (MRI, PET-CT and CT-dosimetry) continue to gain adherents. Some centres treat small numbers of patients, a finding that deserves more attention in terms of cost and quality of care. Although BT remains strong in Spain, it could be further strengthened by making modern dosimetric techniques and treatments more widely available. Content Type Journal ArticleCategory Research ArticlesPages 36-42DOI 10.1007/s12094-012-0759-5Authors Ferran Guedea, Department of Radiation Oncology, Catalan Institute of Oncology, Gran vía s/n, km 2,7, ES-08907 L’Hospitalet de Llobregat, Barcelo...

US Cancer Screening Below National Targets

Health News from Medical News Today — Sat, 28 Jan 2012 11:00:00 +0100

The percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups, according to a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) released on Friday. The report shows that in 2010, the screening rate for breast cancer was 72.4%, compared to the 2020 national target of 81%, for cervical cancer it was 83%, compared to a target of 93%, and for colorectal it was 58.6% percent, compared to a target of 70.5%... (Source: Health News from Medical News Today)

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Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance

BMC Cancer — Sat, 28 Jan 2012 05:00:00 +0100

Conclusions: We characterized a self-renewing subpopulation of CICs found among four well known human cancer-derived cell lines (HeLa, SiHa, Ca Ski and C-4 I) and found that they express characteristic markers of stem cell, EMT and radioresistance. The fact that CICs demonstrated a higher degree of resistance to radiation than differentiated cells suggests that specific detection and targeting of CICs could be highly valuable for the therapy of tumors from the uterine cervix. (Source: BMC Cancer)

Hypofractionated radiotherapy as local hemostatic agent in advanced cancer

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Conclusion : Of 25 patients, 22 (88%) responded, and there was complete cessation of bleeding. Both 15 Gray and 20 Gray dose schedule had equal efficacy. Treatment was well tolerated without any intermission. Radiotherapy is a safe and effective option in controlling tumor bleeding. (Source: Indian Journal of Palliative Care)

Post-treatment follow-up procedures in cervical cancer patients previously treated with radiotherapy

Archives of Gynecology and Obstetrics — Fri, 27 Jan 2012 17:54:59 +0100

Conclusions Chest X-ray and Pap smear can be routinely performed for the first 2 years after radiotherapy, but can be omitted or used sparingly thereafter. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1007/s00404-012-2235-4Authors Seiji Mabuchi, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanFumiaki Isohashi, Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanShintaro Maruoka, Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTakeshi Hisamatsu, Department of Obstetrics and Gynecology, Osaka University Graduate ...

The novel expression of Oct3/4 and Bmi1 in the root development of mouse molars

Cell and Tissue Research — Fri, 27 Jan 2012 17:54:29 +0100

This study aimed to investigate the characteristics of the cells involved in the root elongation. Octamer-binding factor 3/4 (Oct3/4) is known as one of the key regulators in maintaining the pluripotency and self-renewal properties of embryonic stem cells. Bmi1, the polycomb-group transcriptional repressor, has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. At the beginning of root formation, ameloblasts expressed Oct3/4 in the nucleus, except in the apex of the cervical loop, in which Bmi1and cyclinD were expressed. At PN6, the expression of Oct3/4 in the ameloblasts shifted from the nucleus to the cytoplasm, whereas ameloblastin-negative Hertwig’s epithelial root sheath (HERS) cells expressed Bmi1 and cycli...

CDC: Too few Americans getting screened for common cancers

USATODAY.com Health — Fri, 27 Jan 2012 14:54:02 +0100

The number of Americans being screened for colon, breast and cervical cancers still fall below national targets, health officials said. (Source: USATODAY.com Health)

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Oral cancer virus affects 7 per cent in U.S.

CTV Health — Fri, 27 Jan 2012 12:57:32 +0100

About 16 million Americans have oral HPV, a sexually transmitted virus more commonly linked with cervical cancer that also can cause mouth cancer, according to the first nationwide estimate. (Source: CTV Health)

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Fri, 27 Jan 2012 12:34:52 +0100

Men At Greater Risk For Oral HPV Infection, HPV-Related Cancers

Health News from Medical News Today — Fri, 27 Jan 2012 12:00:00 +0100

Oral HPV infection is more common among men than women, explaining why men are more prone than women to develop an HPV related head and neck cancer, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM. Human papillomavirus, or HPV, has recently been linked to some types of head and neck cancer that are becoming more prominent in the United States, mostly among men... (Source: Health News from Medical News Today)

Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla) – no evidence of virus‐induced carcinogenesis

Journal of Medical Primatology — Fri, 27 Jan 2012 09:28:13 +0100

Conclusions Histopathologically and immunohistochemically, the tumour had striking similarities to human endocervicial adenocarcinomas of the common type. However, PCR analysis failed to identify herpes‐ or papillomaviral DNA in the tumor at the time of necropsy, thus leaving the question for cause of the disease open. (Source: Journal of Medical Primatology)

Use of electronic health record data to evaluate overuse of cervical cancer screening

ICMCC: The International Council on Medical and Care Compunetics — Fri, 27 Jan 2012 09:12:36 +0100

Source: Mathias JS et al, J Am Med Inform Assoc, 2012 Content: Background National organizations historically focused on increasing use of effective services are now attempting to identify and discourage use of low-value services. Electronic health records (EHRs) could be used to measure use of low-value services, but few studies have examined this. The aim of [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

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2-Year Study Finds Gardasil Does Not Trigger Autoimmune Conditions After Vaccination

Health News from Medical News Today — Fri, 27 Jan 2012 08:00:00 +0100

Gardasil, the human papillomavirus vaccine that is now recommended for male and female adolescents and young adults, does not trigger autoimmune conditions such as lupus, rheumatoid arthritis, type 1 diabetes or multiple sclerosis after vaccination in young women, according to a new study in the Journal of Internal Medicine. Kaiser Permanente researchers used electronic health records to conduct an observational safety study of 189,629 females aged 9 to 26 years old in California who were followed for six months after receiving each dose of the quadrivalent HPV vaccine in 2006-2008... (Source: Health News from Medical News Today)

Cancer screening - United States, 2010.

MMWR Morb Mortal Wkl... — Fri, 27 Jan 2012 05:00:00 +0100

Authors: Abstract Each year, approximately 350,000 persons are diagnosed with breast, cervical, or colorectal cancer in the United States, and nearly 100,000 die from these diseases. The U.S. Preventive Services Task Force (USPSTF) recommends screening tests for each of these cancers to reduce morbidity and mortality. Healthy People 2020 sets national objectives for use of the recommended cancer screening tests and identifies the National Health Interview Survey (NHIS) as the means to measure progress. Data from the 2010 NHIS were analyzed to assess use of the recommended tests by age, race, ethnicity, education, length of U.S. residence, and source and financing of health care to identify groups not receiving the full benefits of screening and to target specific interventions to...

Development of a Theory-Based (PEN-3 and Health Belief Model), Culturally Relevant Intervention on Cervical Cancer Prevention Among Latina Immigrants Using Intervention Mapping

Health Promotion Practice — Fri, 27 Jan 2012 05:00:00 +0100

The development of efficacious theory-based, culturally relevant interventions to promote cervical cancer prevention among underserved populations is crucial to the elimination of cancer disparities. The purpose of this article is to describe the development of a theory-based, culturally relevant intervention focusing on primary (sexual risk reduction) and secondary (Pap smear) prevention of cervical cancer among Latina immigrants using intervention mapping (IM). The PEN-3 and Health Belief Model provided theoretical guidance for the intervention development and implementation. IM provides a logical five-step framework in intervention development: delineating proximal program objectives, selecting theory-based intervention methods and strategies, developing a program plan, planning for ado...

[Incidental finding of phaeochromocytoma during surgery: The anaesthesiologist's nightmare.]

Annales Francaises d'Anesthesie et de Reanimation — Fri, 27 Jan 2012 05:00:00 +0100

We report the case of a patient who presented hypertension paroxysmal with acute pulmonary oedema followed by cardiocirculatory arrest during gynaecological surgery for resection of latero-aortic lymph nodes suspected to be cervical cancer metastases. This intervention, originally oncologic, has discovered ectopic phaeochromocytoma a posteriori. The management of perioperative serious adverse events revealing the undiagnosed phaeochromocytoma is discussed. PMID: 22285940 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)

Cancer Screening Falls Short, CDC Says (CME/CE)

MedPage Today Infectious Disease — Thu, 26 Jan 2012 21:43:04 +0100

(MedPage Today) -- Large numbers of Americans who should have screening exams for breast, colon, and cervical cancer are not getting them, government researchers said. (Source: MedPage Today Infectious Disease)

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HPV Self-Testing Effective in Rural Chinese WomenHPV Self-Testing Effective in Rural Chinese Women

Medscape Today Headlines — Thu, 26 Jan 2012 21:33:16 +0100

HPV self-testing as a screen for cervical cancer could increase coverage of the large number of geographically isolated Chinese women and of all women who do not have ready access to healthcare. Medscape Medical News (Source: Medscape Today Headlines)

Well: Oral HPV More Common in Men Than Women

NYT — Thu, 26 Jan 2012 19:30:23 +0100

About one in 15 Americans is infected with oral human papillomavirus, a sexually transmitted virus that causes throat cancers, and the disease is especially common among men, new research shows. (Source: NYT)

Vital Signs: Patterns: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 19:30:23 +0100

Vital Signs: Risks: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 19:30:23 +0100

US Cancer Screenings Not Meeting Goals, Says CDCUS Cancer Screenings Not Meeting Goals, Says CDC

Medscape Today Headlines — Thu, 26 Jan 2012 18:41:36 +0100

Testing for cancer of the breast, cervix, and colon/rectum is recommended. Medscape Medical News (Source: Medscape Today Headlines)

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7% Of Americans Have Oral HPV

Health News from Medical News Today — Thu, 26 Jan 2012 17:00:00 +0100

A study published online in JAMA on Thursday suggests 7% of men and women in the US carry the Human papillomavirus (HPV), the virus that causes a distinct form of cancer that affects the part of the throat that sits at the back of the mouth. The study suggests oral HPV infection is predominantly sexually transmitted, and estimates that men are nearly three times more likely to have the virus than women. Maura L. Gillison, Professor in the College of Medicine at Ohio State University (OSU), and others carried out the study... (Source: Health News from Medical News Today)

Self-HPV Testing Could Be An Effective Cervical Cancer Screening Method

Health News from Medical News Today — Thu, 26 Jan 2012 17:00:00 +0100

A study published January 23 in the Journal of the National Cancer Institute , has found that self-HPV (human papillomavirus) testing, in low-resource settings, may be a more effective way to screen for cervical cancer than liquid-based cytology (LBC) and visual inspection with acetic acid (VIA). Cervical cancer is one of the most prevalent cancers found in women. Each year, around 530,000 women are diagnosed with the disease, resulting in an estimated 275,000 deaths... (Source: Health News from Medical News Today)

Too Few Americans Getting Screened for Common Cancers

MedlinePlus Health News — Thu, 26 Jan 2012 17:00:00 +0100

National targets for breast, cervical and colon malignancies still not being metSource: HealthDay Related MedlinePlus Pages: Cancer, Health Disparities, Health Screening (Source: MedlinePlus Health News)

Correlation between physical status of human papilloma virus and cervical carcinogenesis

Journal of Huazhong University of Science and Technology -- Medical Sciences -- — Thu, 26 Jan 2012 16:50:03 +0100

Summary The prevalence of human papilloma virus (HPV)-16 in patients with cervical cancer, the physical status of HPV-16 in patients with cervical lesions, and the role of HPV-16 integration in cervical carcinogenesis were investigated. HPV genotyping was performed by using PCR approach with the primer GP5+/GP6+ and type-specific primer on biopsy specimens taken operatively from 198 women. Multiple PCR was done to detect physical status of HPV-16 in a series of cervical liquid-based cytology samples and biopsy specimens obtained from different cervical lesions with HPV-16 infection, including 112 specimens with cervical cancer, 151 specimens with CIN I, 246 specimens with CIN and 120 specimens with CINIII. The results showed that there were 112 cervical cancer samples (56....

Well: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 15:49:41 +0100

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DIY smear test works for cervical cancer

New Scientist - Health — Thu, 26 Jan 2012 15:29:55 +0100

A do-it-yourself smear test could enable millions of women in poorer countries to head off cervical cancer (Source: New Scientist - Health)

Robotic assisted surgery for gynaecological cancer.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: Well-designed RCTs are required as only low quality evidence from CCTs is available. These studies support the use of robotic assisted surgery for endometrial cancer and cervical cancer, but these findings present a high risk of bias. PMID: 22258988 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Indications Of A Benefit In Primary HPV Testing

Health News from Medical News Today — Thu, 26 Jan 2012 08:00:00 +0100

Precursors of cervical cancer can be detected and treated earlier / Risk of over-treatment Studies currently available provide indications and a "hint" that precursors of cervical cancer can be detected and treated earlier, and consequently tumours occur less often, in women who underwent testing for human papillomavirus (HPV). In this context, an HPV test can be used alone or in addition to a Papanicolaou test (Pap smear). However, both screening procedures also carry a risk of harm in the form of unnecessary treatments after testing (over-treatment)... (Source: Health News from Medical News Today)

Women Can Take Steps to Prevent Cervical Cancer

MedicineNet Cancer General — Thu, 26 Jan 2012 07:00:00 +0100

Title: Women Can Take Steps to Prevent Cervical CancerCategory: Health NewsCreated: 1/25/2012 6:05:00 PMLast Editorial Review: 1/26/2012 (Source: MedicineNet Cancer General)

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Too Few Americans Getting Screened for Common Cancers: CDC

The Doctors Lounge - Gastroenterology — Thu, 26 Jan 2012 05:00:00 +0100

National targets for breast, cervical and colon malignancies still not being met (Source: The Doctors Lounge - Gastroenterology)

Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cells of undetermined significance (ASC-US) in Catalonia, Spain.

BMC Infectious Diseases — Thu, 26 Jan 2012 05:00:00 +0100

Conclusions: Triage of ASC-US with hrHPV testing showed a high sensitivity for the detection of CIN2+ and a high negative predictive value after 3 years of follow-up. The results of this study are in line with the current guidelines for triage of women with ASC-US in the target age range of 25-65. Non adherence to guidelines will lead to unnecessary medical interventions. Further investigation is needed to improve specificity of ASC-US triage. (Source: BMC Infectious Diseases)

CDC: Cancer Screening Below Target Rates

WebMD Health — Thu, 26 Jan 2012 05:00:00 +0100

Screening rates for breast, cervical, and colorectal cancer remain below target levels in the United States and are especially low among Asians and Hispanics, the CDC reports. (Source: WebMD Health)

Women Can Take Steps to Prevent Cervical Cancer

Cancercompass News: Gynecological Cancer — Thu, 26 Jan 2012 00:00:00 +0100

Regular Pap tests, HPV vaccine go a long way in warding off the disease, experts say (Source: Cancercompass News: Gynecological Cancer)

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Advaxis reports safety and survival data of cancer drug

Drug Development Technology — Thu, 26 Jan 2012 00:00:00 +0100

Advaxis has reported the preliminary data on the safety and clinical benefit of ADXS-HPV with or without cisplatin in Indian women with recurrent / refractory cervical cancer who have failed cytotoxic therapy from an ongoing randomised Phase II trial… (Source: Drug Development Technology)

Women Can Take Steps to Prevent Cervical Cancer

The Doctors Lounge - Oncology — Wed, 25 Jan 2012 22:00:00 +0100

Regular Pap tests, HPV vaccine go a long way in warding off the disease, experts say (Source: The Doctors Lounge - Oncology)

Do-It-Yourself HPV TestHelps Screen for Cervical Cancer (CME/CE)

MedPage Today Public Health — Wed, 25 Jan 2012 16:35:37 +0100

(MedPage Today) -- Patient-collected specimens for human papillomavirus DNA testing detected precancerous cervical lesions with accuracy comparable to that of cytology-based Pap screening and visual inspection, data from screening studies showed. (Source: MedPage Today Public Health)

Do-It-Yourself HPV Test Helps Screen for Cervical Cancer (CME/CE)

MedPage Today Hematology/Oncology — Wed, 25 Jan 2012 16:35:37 +0100

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Disruption of CTCF at the miR-125b1 locus in gynecological cancers

BMC Cancer — Wed, 25 Jan 2012 05:00:00 +0100

Conclusions: A reduction of miR-125b1 expression in cancers, correlated with methylation, repressive histone marks and loss of CTCF binding at the promoter region. (Source: BMC Cancer)

Adjunctive testing for cervical cancer screening in low resource settings

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Wed, 25 Jan 2012 05:00:00 +0100

ConclusionsSequential testing combination of VIA and HPV, followed by colposcopy and directed biopsy for diagnosis, combines economic viability with high scientific fidelity. The high specificity and negative predictive value reduce referral and treatment rates, as well as number of visits required for diagnosis. HPV (P) followed by reflex Pap is a suitable option for high resource situations with access to liquid‐based cytology. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

The Role of Transabdominal Sonography in Facilitating Successful Brachytherapy Outcomes in Cervical Cancer

Journal of Diagnostic Medical Sonography — Wed, 25 Jan 2012 05:00:00 +0100

This article discusses the etiology, diagnosis, and treatment of cervical cancer. This article further explains the importance of the brachytherapy technique, the role of transabdominal sonography, and how both can lead to a successful outcome for the patient. (Source: Journal of Diagnostic Medical Sonography)

Fibroblast growth factor receptor-3 in urothelial tumorigenesis☆

Urologic Oncology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Iyer G, Milowsky MI Abstract Fibroblast growth factor receptor-3 (FGFR3) is a receptor tyrosine kinase implicated in the tumorigenesis of multiple malignancies, including bladder and other urothelial cancers, multiple myeloma, and cervical cancer. In urothelial carcinoma (UC), constitutive receptor activation occurs most commonly through substitution of a wild-type residue with cysteine in the extracellular domain of FGFR3, thereby resulting in dimerization (through disulfide bridge formation) and subsequent stimulation of tyrosine kinase activity. Activating mutations of FGFR3 have been observed in up to 70% of non-muscle-invasive bladder tumors, while overexpression of a wild-type receptor, found in approximately 40% of tumors, has been correlated with more invasive dise...

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization.

Virology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Vandermark ER, Deluca KA, Gardner CR, Marker DF, Schreiner CN, Strickland DA, Wilton KM, Mondal S, Woodworth CD Abstract The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. I...

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Identification of a 7-gene signature that predicts relapse and survival for early stage patients with cervical carcinoma

Medical Oncology — Tue, 24 Jan 2012 18:13:14 +0100

In this study, we investigate whether gene expression profiling of cervical cancer could be used to predict the prognosis of patient. A series of 100 primary cervical cancer patients who underwent radical hysterectomy between January 2001 and October 2006 were analyzed for gene expression profiles by using a custom oligonucleotide microarray containing probes for 1440 human tumor-related gene transcripts. Supervised analysis of gene expression data identified 19 genes that exhibited differential expression between cervical cancer and normal cervix. Then, all 100 patients were divided into the training (n = 50) and testing sets (n = 50). Using Cox regression and risk-score analysis, we identified a 7-gene (UBL3, FGF3, BMI1, PDGFRA, PTPRF, RFC4, and NOL7) signature f...

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Tue, 24 Jan 2012 12:32:02 +0100

Cervical Cancer Screening Via Self-Collection

Health News from Medical News Today — Tue, 24 Jan 2012 10:00:00 +0100

Human papillomavirus (HPV) testing of self-collected specimens may be a more effective way to screen for cervical cancer in low-resource settings compared to visual inspection with acetic acid (VIA) and liquid-based cytology (LBC), according to a study published in the Journal of the National Cancer Institute. Cervical cancer is the third most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths... (Source: Health News from Medical News Today)

p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.

Cell Cycle — Tue, 24 Jan 2012 09:52:05 +0100

In this study, we demonstrate that there is no obvious different cytotoxic response between cancer cells with and without functional p53, including the isogenic colon cancer cell lines HCT116p53(+/+) and HCT116p53(-/-), breast cancer cell line MCF7, lung cancer cell line A549 and cervical carcinoma cell line HeLa, after treatment with either siRNA against Plk1, the kinase domain inhibitors BI 2536 and BI 6727 or the PBD inhibitor Poloxin. We suggest that the p53 status is not a predictor for the response of Plk1 inhibition, at least not directly. Yet, the long-term outcomes of losing p53, such as genome instability, could be associated with the cytotoxicity of Plk1 inhibition. Further studies are required to investigate whether other circumstances of cancer cells, such as DNA replication/d...

Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes.

Cell Cycle — Tue, 24 Jan 2012 09:50:44 +0100

Authors: He H, Luo Y Abstract Integrated high-risk human papillomavirus (HPV) DNA was frequently detected in the genomes of cervical carcinoma cells. The HPV E6 and E7 oncoproteins disrupt the functions of tumor suppressors p53 and Rb; thus, understanding the mechanism by which HPV E6 and E7 gene expression is regulated in cancer cells is highly relevant to cancer biology. Brg1 is a catalytic subunit of the SWI/SNF chromatin remodeling complexes that function in the transcriptional regulation of certain cellular genes. Here, we show that knockdown of Brg1 in HeLa cells leads to cell cycle arrest, p53 and Rb protein accumulation and, interestingly, downregulated expression of HPV18 E6 and E7 genes. Brg1 binds the HPV18 LCR in a JunB- and p300-dependent manner and is required for eff...

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Merkel Cell Carcinoma of Unknown Primary Origin

Annals of Surgical Oncology — Tue, 24 Jan 2012 07:52:34 +0100

Conclusions Nodal MCCUP is a rare disease affecting primarily elderly white men. Recurrence is observed in approximately one-third of patients, with a 104 month median overall survival after a multimodal treatment approach consisting of surgery along with adjuvant chemotherapy and radiotherapy in the majority of patients. Content Type Journal ArticleCategory MelanomasPages 1-7DOI 10.1245/s10434-011-2213-2Authors Jeremiah L. Deneve, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USAJane L. Messina, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USASuroosh S. Marzban, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USARicardo J. Gonzalez, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, ...

HPV testing: Indications of a benefit in primary screening

EurekAlert! - Medicine and Health — Tue, 24 Jan 2012 05:00:00 +0100

(Institute for Quality and Efficiency in Health Care) Studies currently available provide indications and a "hint" that precursors of cervical cancer can be detected and treated earlier, and consequently tumors occur less often, in women who underwent testing for HPV than in women who solely received a Pap smear. However, both screening procedures carry the risk of unnecessary treatments after testing. (Source: EurekAlert! - Medicine and Health)

Subcarinal Node Metastasis in Thoracic Esophageal Squamous Cell Carcinoma [ORIGINAL ARTICLES: GENERAL THORACIC]

The Annals of Thoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions Longer tumor length, higher pathologic T stage, lower histologic grade, and positive lymph node metastases of other groups are associated with a higher frequency of subcarinal node metastasis. Subcarinal node metastasis indicates worse prognosis of patients with thoracic esophageal squamous cell carcinoma compared with paraesophageal node metastasis. (Source: The Annals of Thoracic Surgery)

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

BMC Cancer — Tue, 24 Jan 2012 05:00:00 +0100

Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected. Methods: Chromosom...

Women urged to have smear tests

The Irish Times - Health — Tue, 24 Jan 2012 00:19:24 +0100

HEALTH BRIEFING:REGULAR SCREENING stops cervical cancer, according to health specialists at the start of European Cervical Cancer Prevention Week, which runs until Saturday. (Source: The Irish Times - Health)

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Older single women 'dismissing cervical cancer risk'

Telegraph Health — Mon, 23 Jan 2012 07:00:26 +0100

A rise in the number of single older women is putting more at risk of cervical cancer, a charity is warning. (Source: Telegraph Health)

Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G(2)-M arrest and apoptosis in HeLa cells.

Acta Pharmacologica Sinica — Mon, 23 Jan 2012 05:00:00 +0100

Conclusion:6-Chloro-4-(methoxyphenyl) coumarin is a novel microtubule-targeting agent that induces G(2)-M arrest and apoptosis in HeLa cells. PMID: 22266726 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

Isolation and Cytotoxic Activity of Selaginellin Derivatives and Biflavonoids from Selaginella tamariscina

Planta Medica — Mon, 23 Jan 2012 05:00:00 +0100

Planta MedDOI: 10.1055/s-0031-1298175AbstractFive selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin (6), hinokiflavone (7), pulvinatabiflavone (8), and 7′′-O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1-9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two ne...

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Sat, 21 Jan 2012 12:11:32 +0100

Results in a New Study Published in the Annals of Medicine Show...

PRWeb: Medical Pharmaceuticals — Sat, 21 Jan 2012 05:56:11 +0100

The publication of the startling results of a Canadian study involving the effectiveness of the Human Papillomavirus (HPV) vaccine against cervical cancer demonstrate that vaccine policy and...(PRWeb January 18, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9112116.htm (Source: PRWeb: Medical Pharmaceuticals)

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Guided Therapeutics Provides Update on PMA Application for LuViva(R) Advanced Cervical Scan and Timing for Filing of CE Mark

HSMN NewsFeed — Fri, 20 Jan 2012 23:25:36 +0100

Company to Host Conference Call with Investors on January 23 at 10 A.M. EST NORCROSS, Ga.--(Healthcare Sales & Marketing Network)-- Guided Therapeutics, Inc. (OTCBB & OTCQB: GTHP) today announced that the company plans to seek an independent panel revie... Devices, Diagnostics, Oncology, FDA, RegulatoryGuided Therapeutics, LuViva, Advanced Cervical Scan, cervical cancer (Source: HSMN NewsFeed)

Aspirin - Ability To Prevent Cervical Cancer In HIV Infected Women

Health News from Medical News Today — Fri, 20 Jan 2012 16:00:00 +0100

According to a study published in the current issue of the journal Cancer Prevention Research, aspirin should be assessed for its ability to prevent cervical cancer developing in women infected with HIV. Aspirin has the potential to provide considerable benefit for women in Africa, the Caribbean and Latin America, regions where death rates from cervical cancer are extremely high. The study was conducted by global health investigators at New York-Presbyterian Hospital/Weill Cornell Medical Center and cancer specialists in New York, Haiti and Qatar... (Source: Health News from Medical News Today)

Aspirin Merits Testing For Prevention Of Cervical Cancer In HIV-Infected Women

Health News from Medical News Today — Fri, 20 Jan 2012 09:00:00 +0100

Research conducted by NewYork-Presbyterian Hospital/Weill Cornell Medical Center global health investigators and cancer specialists in New York, Qatar and Haiti suggests that aspirin should be evaluated for its ability to prevent development of cervical cancer in HIV-infected women. The report, published in the current issue of journal Cancer Prevention Research, says this simple and inexpensive solution has the potential to provide enormous benefit for women in the Caribbean, Latin America and Africa, who suffer from a disproportionately high rate of cervical cancer death... (Source: Health News from Medical News Today)

$1.6 million grant awarded to develop cervical cancer screening program for under, uninsured

Baylor College of Medicine News — Fri, 20 Jan 2012 05:00:00 +0100

(Source: Baylor College of Medicine News)

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer

Indian Journal of Human Genetics — Fri, 20 Jan 2012 05:00:00 +0100

Koushik ChattopadhyayIndian Journal of Human Genetics 2011 17(3):132-144Cervical cancer is the second most common cancer in women worldwide. This is caused by oncogenic types of human papillomavirus (HPV) infection. Although large numbers of young sexually active women get HPV-infected, only a small fraction develop cervical cancer. This points to different co-factors for regression of HPV infection or progression to cervical cancer. Host genetic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review is to compile the advances in the field of host genetics of cervical cancer. MEDLINE database was searched using the terms, 'HPV', '...

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Cytotoxic Salan-Titanium(IV) Complexes: High Activity Toward a Range of Sensitive and Drug-Resistant Cell Lines, and Mechanistic Insights.

ChemMedChem — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Manna CM, Braitbard O, Weiss E, Hochman J, Tshuva EY Abstract The cytotoxicities of highly efficient salan-Ti(IV) complexes toward a range of cell lines, including drug-resistant cells, are reported along with preliminary mechanistic insights. Five salan-Ti(IV) complexes were investigated toward eight different human and murine cancer-derived cell lines, including colon, ovarian, lung, cervical, pancreatic, leukemic, skin, and breast. The salan complexes are more active toward the cells analyzed than cisplatin and the known titanium compound (bzac)(2) Ti(OiPr)(2) , and no cell line resistant to the salan complexes was identified. Moreover, the salan-Ti(IV) complexes are highly active toward both cisplatin-sensitive (A2780) and cisplatin-resistant (A2780CisR) human ovarian ...

[Left renal vessels as an upper margin of para-aortic lymphadenectomy in cervical cancer: Because we could or because we should?]

Gynecologie, Obstetrique et Fertilite — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Ouldamer L, Marret H, Body G PMID: 22266394 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

Cervical Cancer: The Preventable Gynecologic Cancer

MedlinePlus Health News — Thu, 19 Jan 2012 06:19:49 +0100

Source: Centers for Disease Control and Prevention Related MedlinePlus Pages: Cervical Cancer, HPV (Source: MedlinePlus Health News)

Loss of gene function as a consequence of human papillomavirus DNA integration

International Journal of Cancer — Thu, 19 Jan 2012 05:00:00 +0100

AbstractIntegration of the HPV (human papillomavirus) genome into the host chromatin is a characteristic step in cervical carcinogenesis. Integration ensures constitutive expression of the viral oncogenes E6 and E7 which drive carcinogenesis. However, integration also has an impact on host DNA. There is increasing evidence that integration not only occurs in fragile sites and translocation breakpoints but also in transcriptionally active regions. Indeed, a substantial number of integration sites actually disrupt host genes and may thereby affect gene expression. No doubt, even subtle changes in gene expression may influence the cell phenotype but small fold changes are difficult to quantify reliably in biopsy material. We have therefore addressed the question whether a complete loss of gen...

Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion : Preoperative conditions like hypertension and higher creatinine levels predict development of cervical anastomotic leakage after esophageal cancer surgery. Postoperative consequences accompanying leakage include pulmonary complication and prolonged hospitalization. (Source: Journal of Cancer Research and Therapeutics)

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Diagnostic value of acetic acid comparing with conventional Pap smear in the detection of colposcopic biopsy-proved CIN

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: Since diagnostic values of VIA is comparable to Pap smear, and it performs well in detecting a high grade lesion, we conclude that VIA can be used as a screening modality for cervical cancer in low resource settings. (Source: Journal of Cancer Research and Therapeutics)

P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas

Journal of Clinical Pathology — Thu, 19 Jan 2012 05:00:00 +0100

Conclusions Results suggest that p16 expression is an important predictive factor of LN metastasis in cervical cancer patients. Moreover, p16 overexpression is associated with a poor prognosis. Therefore, immunohistochemical evaluation of p16 expression is of potential value for treatment planning in cervical carcinomas. (Source: Journal of Clinical Pathology)

Transcriptional analysis of human papillomavirus type 16 in histological sections of cervical dysplasia by in situ hybridisation

Journal of Clinical Pathology — Thu, 19 Jan 2012 05:00:00 +0100

Conclusions This data represents new information on HPV-16 viral transcription events that bring into question some of the current beliefs on the mechanism of HPV-16 infection in the progression to cervical cancer. Results support high expression of the E5 and E7 oncogenes in cervical dysplasias infected by HPV-16 in contrast to the low levels identified for the E6 oncogene and a possible alternative transcript for the E2 gene. The diagnostic utility of the detection of HPV-16 RNA transcripts is becoming more apparent and a renewed look at their in situ localisation in cervical biopsies could be beneficial. (Source: Journal of Clinical Pathology)

Use of electronic health record data to evaluate overuse of cervical cancer screening.

Journal of the American Medical Informatics Association — Thu, 19 Jan 2012 05:00:00 +0100

ConclusionSecondary analysis of EHR data can accurately measure the use of low-value services such as Pap testing performed sooner than recommended in women at low risk of cervical cancer. Similar application of our methodology could facilitate efforts to simultaneously improve quality and decrease costs, maximizing value in the US healthcare system. PMID: 22268215 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)

Time trends in cervical cancer epidemiology in the Slovak Republic: reflection on the non-implementation of screening with international comparisons.

Neoplasma — Thu, 19 Jan 2012 04:30:02 +0100

Time trends in cervical cancer epidemiology in the Slovak Republic: reflection on the non-implementation of screening with international comparisons. Neoplasma. 2012;59(2):121-8 Authors: Ondrusova M, Zubor P, Ondrus D Abstract Cervical cancer is a serious public health problem with high geographical variations in incidence, mainly due to historical patterns of risk factors and the influence of screening activities. To reduce both cervical cancer incidence and mortality is the primary objective of organized screening and annual reports of high quality utilising accepted interventional measures. Currently, the time-trends in overall incidence and mortality from cervical cancer in the Slovak Republic are implacable. The high incidence values of this condition that have stabi...

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Review of cytology and histopathology as part of the NHS Cervical Screening Programme audit of invasive cervical cancers

Cytopathology — Wed, 18 Jan 2012 05:51:56 +0100

Conclusions: In spite of the excellent quality of cytology in England, a high proportion of negative cytology taken up to three and a half years before diagnosis were considered to contain abnormal cells by reviewers informed of the subsequent cancer. Continuing these reviews, with a strong focus on education, will ensure a clear understanding of these slides and further reduce the risk of developing cervical cancer. (Source: Cytopathology)

Type 1 and type 2 cervical carcinomas: some cervical cancers are more difficult to prevent with screening

Cytopathology — Wed, 18 Jan 2012 05:51:54 +0100

R. M. Austin and C. Zhao  Type 1 and type 2 cervical carcinomas: some cervical cancers are more difficult to prevent with screeningAlthough the Papanicolaou (Pap) smear is medical history’s most successful cancer screening test, some cervical cancers are more difficult to prevent with screening than others. Cervical cancers that are difficult to prevent are seen disproportionately among interval cancers arising in previously screened women and in Pap test litigation. These include (i) rapidly progressing cervical cancers; (ii) cervical cancers in younger women; (iii) glandular cervical cancers; and (iv) cervical cancers in elderly women. Screening protocols have generally been designed to optimize prevention of slower‐growing cervical squamous carcinomas in middle‐aged women. To fo...

Aspirin merits testing for prevention of cervical cancer in HIV-infected women

EurekAlert! - Medicine and Health — Wed, 18 Jan 2012 05:00:00 +0100

(New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College) Research conducted by NewYork-Presbyterian Hospital/Weill Cornell Medical Center global health investigators and cancer specialists in New York, Qatar and Haiti suggests that aspirin should be evaluated for its ability to prevent development of cervical cancer in HIV-infected women. (Source: EurekAlert! - Medicine and Health)

Cost-effectiveness of cervical cancer screening: cytology versus human papillomavirus DNA testing.

BJOG : An International Journal of Obstetrics and Gynaecology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions Increasing the interval between screening rounds and changing the primary test from cytology to HPV testing can improve the effectiveness and decrease the costs of cervical cancer screening in the Netherlands. PMID: 22251259 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Cost‐effectiveness of cervical cancer screening: cytology versus human papillomavirus DNA testing

BJOG: An International Journal of Obstetrics and Gynaecology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions Increasing the interval between screening rounds and changing the primary test from cytology to HPV testing can improve the effectiveness and decrease the costs of cervical cancer screening in the Netherlands. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

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A poly(glycerol-sebacate-(5-fluorouracil-1-acetic acid)) polymer with potential use for cancer therapy

Journal of Bioactive and Compatible Polymers — Wed, 18 Jan 2012 05:00:00 +0100

In this study, 5-fluorouracil-1-acetic acid was chemically conjugated with poly(glycerol-sebacate) (PGS) to form a unitary polymer poly(glycerol-sebacate- (5-fluorouracil-1-acetic acid)) (PGS-5-FU-CH2COOH). The structure, the in vitro antitumor activity of 5-FU-CH2COOH, the in vitro degradation, the drug release, and antitumor activity as well as the in vivo degradation and tissue biocompatibility of PGS-5-FU-CH2COOH were investigated. The 5-FU-CH2COOH inhibited HeLa (human cervical cancer cell line) and SGC-7901 (human gastric adenocarcinoma cell line) tumor cells with a half maximal inhibitory concentration (IC50) of 0.196 and 0.267 μM, respectively, after a 3-day incubation. The in vitro drug release profiles of PGS-5-FU-CH2COOH exhibited a biphasic release with an initial exponentia...

Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer.

Clinical Cancer Research — Wed, 18 Jan 2012 05:00:00 +0100

CONCLUSIONS: Activation of the PI3K/Akt pathway is associated with incomplete metabolic response in cervical cancer. Targeted inhibition of PI3K/Akt may improve response to chemoradiation. PMID: 22235101 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Clinical Utility of Functional Imaging with 18F-FDOPA in Von Hippel-Lindau Syndrome.

The Journal of Clinical Endocrinology and Metabolism — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions:(18)F-FDOPA PET is a useful complementary imaging study to detect neuroendocrine tumors in patients with VHL undergoing surveillance, especially in those suspected to have adrenal pheochromocytoma or unusual ectopic locations. PMID: 22259055 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Solar cheilosis: An ominous precursor: Part I. Diagnostic insights

Journal of the American Academy of Dermatology — Tue, 17 Jan 2012 18:08:57 +0100

Squamous cell carcinoma (SCC) of the lower lip is a deadly nonmelanoma skin cancer. Its precursor, a distinctive cutaneous neoplasia analogous to cervical dysplasia, is known by the confusing term actinic cheilitis. Solar cheilosis (SC) is a more appropriate designation. It represents incipient SCC in situ. SC is widely recognized as an ultraviolet light–induced precancer of the lower lip that is typically seen in light-skinned individuals and others with poorly pigmented lower lips. Lip SCC is one of the most common malignancies of the oral cavity. SCC is much more likely to metastasize from the lip than cutaneous surfaces, with a 5-year overall survival rate of less than 75%. SC results from long-term exposure to ultraviolet radiation. The occurrence of SC is dose-dependent and is infl...

Gynecologic Cancer

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

Like many areas in oncology, gynecologic oncology has made several important recent advances in both the prevention and the treatment of reproductive malignancies. New knowledge related to risk factors for endometrial and ovarian cancer has led to novel strategies to reduce risks through diet, contraception choices, and other factors. Important advances have also occurred in the understanding of genetic risks for gynecologic cancers and genetic testing can now identify individuals at substantial risk. Patients at genetic risk can reduce their risk through the use of oral contraception and other choices if they have not completed their families or undergo definitive prophylactic surgery when they no longer desire future pregnancies. Cervical cancer is an area of particular advancement in pr...

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New Biologic Agents for the Treatment of Gynecologic Cancers

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

This article provides an update on the state of targeted therapy testing in gynecologic cancers. (Source: Hematology/Oncology Clinics of North America)

Physiological 18F-FDG uptake by the spinal cord: is it a point of consideration for cancer patients?

Journal of Neuro-Oncology — Tue, 17 Jan 2012 07:19:32 +0100

Abstract It is essential to be familiar with normal patterns of 18F FDG distribution in the whole body for accurate PET interpretation. We assessed FDG uptake by the spinal cord to evaluate its characteristics in cancer patients. For 101 cancer patients who underwent 18F FDG PET/CT the spinal cord along its segments was visually assessed for FDG uptake, regarding MaxSUV-measurement ≥1 as cut-off point. This assessment was correlated with the patient’s database variables. MRI and FDG PET-CT follow-up were included in the evaluation of positive subjects with FDG cord uptake. Forty-nine (48.5%) were positive for FDG cord uptake. The most encountered sites were the eleventh and twelfth dorsal vertebrae (36/49; 73.5%), all cervical (24/49; 49%), and the first lumbar segments ...

The value of PET/CT to assess clinically negative necks

European Archives of Oto-Rhino-Laryngology — Tue, 17 Jan 2012 07:18:53 +0100

Abstract The aim was to evaluate the efficacy of [18F]-2-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in evaluating metastasis of head and neck squamous cell carcinoma (HNSCC) to the cervical lymph nodes, with specific attention to the efficacy in regard to clinically negative necks. This was a retrospective review of 243 patients with HNSCC between years 2005 and 2007 treated at a comprehensive cancer care institution who underwent pre-operative PET/CT and neck dissection with either an N0 (112 patients) or N+ (131 patients) clinical nodal status. PET/CT findings were correlated with histopathological results of surgical specimens. A majority of the primary sites were oral cavity and oropharynx (70%), followed by larynx, unknown primary and ...

Be aware of common cervical cancer symptoms

Baylor College of Medicine News — Tue, 17 Jan 2012 05:00:00 +0100

(Source: Baylor College of Medicine News)

Help prevent cervical cancer with HPV vaccine

Baylor College of Medicine News — Tue, 17 Jan 2012 05:00:00 +0100

Getting the human papillomavirus, or HPV, vaccine provides an important preventative benefit against cervical cancer, said a gynecologic oncologist from Baylor College of Medicine . "Disease prevention and early detection are key in the battle against cancer," said Dr. Celestine Tung, an assistant professor in the department of obstetrics and gynecology in the division of gynecologic oncology at BCM. "With cervical cancer, now we have a way to prevent it with the HPV vaccine." HPV and cervical cancer Approximately 95 percent of cervical cancers are associated with HPV infections, and between 70 to 80 percent of cervical cancers are related to HPV 16 and HPV 18 viral subtypes or strains, Tung said. HPV is the most common sexually transmitted infection affecting between 3...

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HPV DNA testing in population-based cervical screening (VUSA-Screen study): results and implications

British Journal of Cancer AOP — Tue, 17 Jan 2012 05:00:00 +0100

Authors: D C Rijkaart, J Berkhof, F J van Kemenade, V M H Coupe, L Rozendaal, D A M Heideman, R H M Verheijen, S Bulk, W Verweij, P J F Snijders & C J L M Meijer (Source: British Journal of Cancer AOP)

Cancer burden in Africa and opportunities for prevention

Cancer — Tue, 17 Jan 2012 05:00:00 +0100

AbstractCancer is an emerging public health problem in Africa. About 715,000 new cancer cases and 542,000 cancer deaths occurred in 2008 on the continent, with these numbers expected to double in the next 20 years simply because of the aging and growth of the population. Furthermore, cancers such as lung, female breast, and prostate cancers are diagnosed at much higher frequencies than in the past because of changes in lifestyle factors and detection practices associated with urbanization and economic development. Breast cancer in women and prostate cancer in men have now become the most commonly diagnosed cancers in many Sub‐Saharan African countries, replacing cervical and liver cancers. In most African countries, cancer control programs and the provision of early detection and treatme...

Prognostic Significance of Adenocarcinoma Histology in Women with Cervical Cancer.

Gynecologic Oncology — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSION: Cervical adenocarcinomas are more common in younger women and white patients. Adenocarcinoma histology negatively impacts survival for both early and advanced-stage carcinomas. PMID: 22266551 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)](n) complexes against human cancer cell lines.

Toxicology in Vitro — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Dvořák Z, Starha P, Sindelář Z, Trávníček Z Abstract The 1d-polymeric iron(III) complexes [Fe(salen)(μ-L)](n) (1-6), involving a deprotonated form of the N-donor heterocyclic compounds (l) imidazole (complex 1), 1,2,4-triazole (2), benztriazole (3), 5-methyltetrazole (4), 5-aminotetrazole (5) and 5-phenyltetrazole (6), were studied for their in vitro cytotoxic activity against human cancer cell lines including lung carcinoma (A549), cervix epithelial carcinoma (HeLa), osteosarcoma (HOS), malignant melanoma (G361), breast adenocarcinoma (MCF7), ovarian carcinoma (A2780) and cisplatin-resistant ovarian carcinoma (A2780cis). Cytotoxicity in vitro (IC(50)=0.39-0.48μM) was achieved for 2-6 against A2780 (IC(50) of cisplatin equals 11.5μM) as well as for 5 and 6 agains...

January 2012 Newsletter and Updates from The Hysterectomy Association

The Hysterectomy Association — Mon, 16 Jan 2012 18:46:53 +0100

Welcome to 2012 and we will shortly be entering the Chinese Year of the Dragon – it will arrive with a roar on 23rd January and symbolises luck. Here in the Hysterectomy Association office we hope that all our lovely subscribers receive the luck they want and need for their ongoing health. January is famously the time to get colds and bugs too (when you are in the Western Hemisphere at least) so it’s essential to wrap up warm if you go out and to avoid anyone who happens to be suffering – especially if you are recovering from surgery. Perhaps now is the time to think about catching up on all those books you were planning to read or the films you wanted to watch. Our Latest News DHEA Hormone may help to ease menopause symptoms and improve sex lives - Researchers in Ita...

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Cervical screening age set to rise in Scotland and Wales

HealthcareRepublic Pharmacist News — Mon, 16 Jan 2012 16:04:00 +0100

Scotland and Wales look set to raise the age women are first invited by their GP for cervical cancer screening to 25, after an expert panel said testing younger women may cause more harm than good. (Source: HealthcareRepublic Pharmacist News)

Mechanisms of Cyst Formation in Metastatic Lymph Nodes of Head and Neck Squamous Cell Carcinoma

Diagnostic Pathology — Mon, 16 Jan 2012 05:00:00 +0100

Cystic change in metastatic lymph nodes occurs in certain types of tumors and mostly in squamous cell carcinoma of the head and neck. In the majority of cases, psuedocystic change is the mechanism of cyst formation. However, sometimes a true cyst cavity is formed. This occurrence is unexplained and some theories are introduced to explain it. In this paper, related articles and introduced concepts are reviewed and the best conclusions of present hypotheses are provided. Cystic SCC in cervical lymph node is now considered as a typical presentation of metastatic SCC arising in the oro/nasopharynx. True cystic cavities have eosinophilic fluid content and present active transport mechanism across the epithelium; Cytokeratin7 is also expressed in the lining of these cysts, which is an accepted m...

Cervical cancer among Aboriginal women in Canada.

cmaj — Mon, 16 Jan 2012 05:00:00 +0100

Authors: Demers AA, Kliewer EV, Remes O, Onysko J, Dinner K, Wong T, Jayaraman GC PMID: 22249991 [PubMed - as supplied by publisher] (Source: cmaj)

Highlights from this issue

Sexually Transmitted Infections — Sun, 15 Jan 2012 05:00:00 +0100

New approaches to partner notification have emerged over the past decade. This month we publish the clinical and economic results of a trial of ‘Accelerated Partner Therapy’, a form of expedited partner therapy adapted to the legislative framework of the UK.1 An editorial by Dombrowski and Golden2 provides a perspective from ‘across the pond’ on the potential of Accelerated Partner Therapy. Policymakers and practitioners will always have to adapt partner notification practice to local professional and cultural contexts, so it is good to see new models of partner notification emerging that may serve the needs of countries where straightforward patient delivered therapy is not approved. We are pleased to include an editorial this month by David Gurnham, an academic la...

Confusion regarding cervical cancer screening and chlamydia screening among sexually active young women

Sexually Transmitted Infections — Sun, 15 Jan 2012 05:00:00 +0100

Conclusion Many younger women in an urban community health centre believed that cervical cancer screening also screens for chlamydia and were confused about chlamydia screening schedules. As there is limited knowledge of the revised ACOG cervical cancer screening guidelines, there is a risk that currently low chlamydia screening rates may decrease further after these new guidelines are better known. Obstetrician gynaecologists and primary care providers should educate younger women about the differences between chlamydia and cervical cancer screening and encourage sexually active younger women to have annual chlamydia screening. (Source: Sexually Transmitted Infections)

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[Study of surplus cost of robotic assistance for radical hysterectomy, versus laparotomy and standard laparoscopy.]

Gynecologie, Obstetrique et Fertilite — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: The average cost for radical hysterectomy was highest for robotic, followed by standard laparoscopy, and least for laparotomy. However, over only 2 years of use, this difference tends to decrease. Medico-economic impact is the main restraint for robotic assistance development, and needs to be assessed permanently. PMID: 22252053 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

Woman, 23, died of cervical cancer 'because doctors said she was too young for a smear test'

the Mail online | Health — Sat, 14 Jan 2012 02:52:12 +0100

Mercedes Curnow (pictured) from Cornwall, first went to her GP at 20 years old but her mother says her symptoms were 'ignored' because of her age. (Source: the Mail online | Health)

The use of hyperbaric oxygen for treating delayed radiation injuries in gynecologic malignancies: a review of literature and report of radiation injury incidence

Supportive Care in Cancer — Fri, 13 Jan 2012 17:17:19 +0100

Conclusions There is level A evidence for using HBOT to treat radiation proctitis. There is level B evidence for using HBOT to treat radiation cystitis and necrosis. The incidence delayed radiation injuries can be as high as 23%. This has relevance in practice guidelines for the treatment of delayed radiation injuries in gynecologic malignancies. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00520-012-1379-xAuthors Scott Allen, Medical College of Wisconsin, Milwaukee, WI 53226, USAChris Kilian, Medical College of Wisconsin, Milwaukee, WI 53226, USAJenise Phelps, Medical College of Wisconsin, Milwaukee, WI 53226, USAHarry T. Whelan, Medical College of Wisconsin, Milwaukee, WI 53226, USA Journal Supportive Care in CancerOnline ISSN ...

Doe Race And Gender Play Role? Obesity And Cancer Screening

Health News from Medical News Today — Thu, 12 Jan 2012 14:00:00 +0100

According to a recent study by researchers in Family and Community Medicine at the Thomas Jefferson University published in the current issue of the Journal of Obesity, obesity is associated with higher rates of prostate cancer screening amongst all races and ethnic differences as well as lower rates of cervical cancer screening predominantly in white women. The study examined the role of obesity in cancer screening rates for prostate, cervical as well as breast and colorectal cancers across race, ethnicity and gender... (Source: Health News from Medical News Today)

Does Race And Gender Play Role? Obesity And Cancer Screening

Health News from Medical News Today — Thu, 12 Jan 2012 14:00:00 +0100

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Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

Journal of Cancer Research and Clinical Oncology — Wed, 11 Jan 2012 17:51:11 +0100

Conclusions microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion. Content Type Journal ArticleCategory Original PaperPages 1-4DOI 10.1007/s00432-012-1147-9Authors Jinjin Yu, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaYuan Wang, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaRuofan Dong, Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi, 214062 People’s Republic of ChinaXiaoyan Huang, Department...

PCR-based Mass Spectrometry System for High-risk HPVPCR-based Mass Spectrometry System for High-risk HPV

Medscape Today Headlines — Wed, 11 Jan 2012 11:19:07 +0100

This clinical trial assessed the utility of the MALDI-TOF mass spectrometry system for cervical cancer screening. Can this complex technology be effective for reaching under-served populations? American Journal of Clinical Pathology (Source: Medscape Today Headlines)

How Obesity Affects Cancer Screening

Health News from Medical News Today — Wed, 11 Jan 2012 08:00:00 +0100

Researchers in Family and Community Medicine at Thomas Jefferson University recently found that obesity was linked to higher rates of prostate cancer screening across all races/ethnic differences and lower rates of cervical cancer screening, most notably in white women. Their study on the role of obesity in cancer screening rates for prostate, cervical as well as breast and colorectal cancers across race/ethnicity and gender is examined in the current issue of the Journal of Obesity... (Source: Health News from Medical News Today)

Viral infections and human cancers: the legacy of Denis Burkitt

British Journal of Haematology — Wed, 11 Jan 2012 05:00:00 +0100

SummaryDenis Parsons Burkitt was born in 1911, and in the late 1950s, described the disease that has come to be known as Burkitt lymphoma based on cases he observed in Uganda. Subsequently, Burkitt lymphoma was recognized as the first human tumour associated with an infectious agent when Epstein–Barr virus was isolated from samples supplied by Burkitt. It is now recognized that over one‐quarter of cancers worldwide are tied to infections. Notably, liver cancer is linked to hepatitis B virus and hepatitis C virus infections, and cervical cancer to infections involving the human papilloma viruses. In addition, immunocompromise arising from infection with the human immunodeficiency virus allows tumours (e.g., Kaposi sarcoma) caused by other viruses to arise. More than 50 years after the...