MedWorm: Clear Cell Carcinoma

Hyalinizing clear cell adenocarcinoma of the oropharynx

Head and Neck — Thu, 02 Feb 2012 05:00:00 +0100

ConclusionImmunohistochemical staining is essential for narrowing the differential diagnosis of these lesions. Treatment is controversial but usually consists of wide local excision and possibly a neck dissection. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Kidney Papillary Carcinoma

Kidney Cancer Association — Wed, 01 Feb 2012 03:55:30 +0100

Kidney clear cell carcinoma is the most common type of kidney cancer, representing approximately 92 percent of such cases. Papillary carcinoma accounts for about 8 percent.02/02/2012 (Source: Kidney Cancer Association)

Value of PAX8 and WT1 Immunostaining in Confirming the Ovarian Origin of Metastatic Carcinoma in Serous Effusion Specimens.

American Journal of Clinical Pathology — Thu, 26 Jan 2012 22:54:33 +0100

Authors: Zhao L, Guo M, Sneige N, Gong Y Abstract We evaluated the detection rates of PAX8 and WT1 immunostaining in 68 (45 as cell blocks, 23 as smears) serous effusion specimens that had a cytologic diagnosis of metastatic carcinoma of ovarian origin. Of the cases, 58 (85%) were positive for PAX8, 56 (82%) were positive for WT1, and 64 (94%) were immunoreactive with either or both markers. Detection rates of PAX8 and WT1 were 85% (44/52) and 92% (48/52), respectively, for metastatic serous carcinoma and 100% (5/5) and 20% (1/5), respectively, for metastatic clear cell carcinoma. Detection rates using cell blocks and smears were 91% and 78%, respectively, with PAX8 and 82% and 83%, respectively, with WT1. We concluded that PAX8 and WT1 had comparable overall detection rates in con...

Clinical features and surgical management of four peculiar cases of intracranial metastases from renal cell carcinoma

Neurological Sciences — Tue, 24 Jan 2012 07:34:35 +0100

In this study, four patients (age range 56–72 years) were treated for intracranial metastases from renal cell carcinoma. The metastasis was solitary in all four patients and was located in the temporoparietal region in two patients, cerebellum in one patient, and bilateral lateral ventricles in one patient. Preoperative magnetic resonance imaging showed hemorrhage and necrosis in the tumor in all four patients, and one patient had edema in the region of the tumor. All patients were treated with craniotomy for tumor resection, and histopathologic examination showed clear cell carcinoma. Marked bleeding occurred in all patients during the operation, but preoperative direct injection of ethanol into epidural metastases (2 patients) was effective in decreasing intraoperative blood...

Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients

BMC Research Notes — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: A significant prognostic value of MSN and CLDN7 in predicting disease outcomes in patients with EC was not demonstrated. Nevertheless, the high percentage of EC cases with MSN and CLDN7 immunoexpression, and their association with tumor grade and subtypes, suggests that these proteins might play a role in tumorigenesis of endometrial adenocarcinomas. Future studies are needed to shed light on their mechanistic properties in EC cells. (Source: BMC Research Notes)

Palliation of dysphagia with radiotherapy for exophytic base tongue metastases in a case of renal cell carcinoma

Indian Journal of Urology — Wed, 04 Jan 2012 05:00:00 +0100

Tabassum Wadasadawala, Prabhash Kumar, Jaiprakash Agarwal, Sarbani Ghosh-LaskarIndian Journal of Urology 2011 27(4):550-552Base tongue involvement is a rare presentation of lingual metastases from renal cell carcinoma. A 48-year-old gentleman was treated with open radical nephrectomy and adjuvant radiotherapy for Stage II Furhman grade I clear cell carcinoma of the left kidney at an outside hospital. He presented metachronously 5 years later with progressive dysphagia and change of voice. Clinicoradiological evaluation revealed a large exophytic mass in the oropharynx with epicenter in the right base of tongue. Metastatic workup revealed widespread dissemination to multiple organs and bone. In view of predominant symptom of dysphagia, base tongue metastasis was treated with protracted cour...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Ovarian Clear-Cell Carcinoma Changing to Produce Parathyroid Hormone-Related Protein with Recurrence

Journal of Gynecologic Surgery — Fri, 23 Dec 2011 14:17:52 +0100

Journal of Gynecologic Surgery Dec 2011, Vol. 27, No. 4: 277-279. (Source: Journal of Gynecologic Surgery)

Unexpected ovarian malignancy after conservative laparoscopic surgery: five case series in a half decade of experience

Archives of Gynecology and Obstetrics — Wed, 21 Dec 2011 20:07:58 +0100

Conclusion The main concern for laparoscopic management of ovarian masses is unexpected malignancy. However, with careful patient selection, proper technique and an experienced operator, laparoscopic treatment of ovarian masses is the best approach and should be implemented, with low risk of unexpected malignancy and recurrence. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2177-2Authors Noraziana Abd Wahab, Department of Obstetrics and Gynecology, Kulliyyah of medicine, Jalan Hospital, International Islamic University, 25710 Kuantan, Pahang, MalaysiaAmphan Chalermchockchareonkit, Department of Obstetrics and Gynecology, Thai-German Multidisciplinary Endoscopic Training Center, Faculty of Medicine Siriraj Hospital, Mahidol ...

Morphometic Analysis of TCGA Glioblastoma Multiforme

BMC Bioinformatics - Latest articles — Tue, 20 Dec 2011 05:00:00 +0100

Conclusion: While subtyping is often performed with genome-wide molecular data, we have shown that it can also be applied to categorizing histology sections. Accordingly, we have identified a subtype that is a predictor of the outcome as a result of a therapeutic regime. Computed representation has become publicly available through our Web site. (Source: BMC Bioinformatics - Latest articles)

Salvage chemotherapy for recurrent or persistent clear cell carcinoma of the ovary: a single-institution experience for a series of 20 patients

International Journal of Clinical Oncology — Fri, 09 Dec 2011 17:07:06 +0100

Conclusion Although most chemotherapeutic regimens for recurrent or persistent CCC have little or no effect, gemcitabine showed modest activity and is the most effective agent we have tested to date. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10147-011-0357-5Authors Kiyoshi Yoshino, Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTakayuki Enomoto, Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanMasami Fujita, Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanYutaka Ueda, Department of Obstetri...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations

Modern Pathology AOP — Fri, 09 Dec 2011 05:00:00 +0100

Authors: Sohei Yamamoto, Hitoshi Tsuda, Masashi Takano, Seiichi Tamai & Osamu Matsubara (Source: Modern Pathology AOP)

Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma

Cancer — Fri, 02 Dec 2011 05:00:00 +0100

CONCLUSION:These findings indicate that ZNF217 overexpression is critical to growth and survival of OCCCs with ZNF217 gene amplification. Furthermore, they suggest that ZNF217 siRNA‐induced phenotypes depend on amplification status of OCCCs. Therefore, ZNF217‐targeted therapy may benefit OCCC patients with ZNF217 amplification. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention

Journal of Cancer Research and Clinical Oncology — Mon, 21 Nov 2011 18:09:32 +0100

Conclusions RCCs were found to be slow growing in a group of untreated renal cell carcinoma patients. However, some tumors progressed in stage under observation. The growth rate of RCC tended to correlate with histologic grade and histologic subtype. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1083-0Authors Xue-Song Li, Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaLin Yao, Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, No. 8 Xishiku St, Xicheng District, Beijing, 100034 ChinaKan Gong, Department ...

Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma

Modern Pathology AOP — Fri, 18 Nov 2011 05:00:00 +0100

Authors: Atsuko Katagiri, Kentaro Nakayama, Mohammed Tanjimur Rahman, Munmun Rahman, Hiroshi Katagiri, Naomi Nakayama, Masako Ishikawa, Tomoka Ishibashi, Kouji Iida, Hiroshi Kobayashi, Yoshiro Otsuki, Satoru Nakayama & Kohji Miyazaki (Source: Modern Pathology AOP)

A prospective blinded comparison of the accuracy of transvaginal sonography and frozen section in the assessment of myometrial invasion in endometrial cancer.

Gynecologic Oncology — Fri, 18 Nov 2011 05:00:00 +0100

CONCLUSION: Intraoperative FS performed better than preoperative TVS in the assessment of myometrial invasion by endometrial cancer. Despite being time-consuming, FS can be regarded as a useful modality in order to decide whether to perform lymphadenectomy in cases with poor visualization of the endometrium at TVS and when TVS gives inconclusive results. PMID: 22108256 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Rare Malignant and Benign Salivary Gland Epithelial Tumors

Surgical Pathology Clinics — Sun, 13 Nov 2011 17:11:53 +0100

Abstract: Although at least 24 distinct histologic salivary gland carcinomas exist, many of them are rare, comprising only 1% to 2% of all salivary gland tumors. These include epithelial-myoepithelial carcinoma, (hyalinizing) clear cell carcinoma, basal cell adenocarcinoma, cystadenocarcinoma, low-grade salivary duct carcinoma (low-grade cribriform cystadenocarcinoma), oncocytic carcinoma, and adenocarcinoma not otherwise specified. Few tumors (clear cell carcinoma and basal cell adenocarcinoma) have unique molecular correlates. Benign tumors, although histologically less diverse, are far more common, with pleomorphic adenoma and Warthin tumor the most common salivary gland tumors. Many benign tumors have malignant counterparts for which histologic distinction can pose diagnostic challenge...

Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: Is it possible?

Human Reproduction — Thu, 10 Nov 2011 05:00:00 +0100

CONCLUSIONS Although our study did not have sufficient power to yield a definite conclusion, our data suggests that at least patients with stage IA CCC may be treated with FSS. (Source: Human Reproduction)

Laparoscopic management of large ovarian tumors: Clinical tips for overcoming common concerns

Journal of Obstetrics and Gynaecology Research — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion: Laparoscopic management of large ovarian tumors is feasible and efficient with appropriate patient selection and experience of surgeons. (Source: Journal of Obstetrics and Gynaecology Research)

Survival Impact of Adjuvant Paclitaxel and Carboplatin for Early-Stage Ovarian Clear-Cell Carcinoma with Complete Surgical Staging

Gynecologic and Obstetric Investigation — Mon, 24 Oct 2011 23:00:00 +0100

Gynecol Obstet Invest (DOI:10.1159/000327924) (Source: Gynecologic and Obstetric Investigation)

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

Human Mutation — Tue, 18 Oct 2011 04:00:00 +0100

AbstractMutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas. To determine the prevalence of mutations in other tumor types, we evaluated 759 malignant neoplasms including those of the pancreas, breast, colon, stomach, lung, prostate, brain and blood (leukemias). We identified truncating mutations in 6% of the neoplasms studied; non‐truncating somatic mutations were identified in an additional 0.4% of neoplasms. Mutations were most commonly found in gastrointestinal samples with 12 of 119 (10%) colorectal and 10 of 100 (10%) gastric neoplasms, respectively, harboring changes. More than half of the mutated colorectal and gastric cancers displayed microsatellite instability and the mutations in these tumors were ou...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Endometrial Carcinomas: A Review Emphasizing Overlapping and Distinctive Morphological and Immunohistochemical Features

Advances in Anatomic Pathology — Sat, 15 Oct 2011 19:38:22 +0100

This review focuses on the most common diagnostic pitfalls and helpful morphologic and immunohistochemical markers in the differential diagnosis between the different subtypes of endometrial carcinomas, including: (1) endometrioid versus serous glandular carcinoma, (2) papillary endometrioid (not otherwise specified, villoglandular and nonvillous variants) versus serous carcinoma, (3) endometrioid carcinoma with spindle cells, hyalinization, and heterologous components versus malignant mixed müllerian tumor, (4) high-grade endometrioid versus serous carcinoma, (5) high-grade endometrioid carcinoma versus dedifferentiated or undifferentiated carcinoma, (6) endometrioid carcinoma with clear cells versus clear cell carcinoma, (7) clear cell versus serous carcinoma, (8) undifferentiated versu...

Cytopathologic findings and differential diagnostic considerations of primary clear cell carcinoma of the lung

Diagnostic Cytopathology — Tue, 11 Oct 2011 04:00:00 +0100

We report here the cytopathological features of CLCC of the lung with an emphasis on differential diagnostic considerations. Diagn. Cytopathol. 2011; © 2011 Wiley‐Liss, Inc. (Source: Diagnostic Cytopathology)

Tumor-to-Tumor Metastasis to Chromophobe Renal Cell Carcinoma: A First Report

Clinical and Developmental Immunology — Wed, 05 Oct 2011 22:54:55 +0100

Tumor-to-tumor metastasis is a rare phenomenon. From our review of the international literature, around 150 cases have been reported since it was first documented by Campbel in 1868. Renal clear cell carcinoma is well known to be the most common recipient of tumor-to-tumor metastasis in all tumors. However, renal chromophobe cell carcinoma has not been reported to be a recipient. Here, we report a first case of colorectal carcinoma metastatic to chromophobe renal cell carcinoma. (Source: Clinical and Developmental Immunology)

Robotic-assisted partial Nephrectomy: initial experience in South America

International Braz J Urol — Tue, 04 Oct 2011 00:39:26 +0100

CONCLUSION: Robotic-assisted partial nephrectomy is safe and represents a valuable option to perform minimally invasive nephron-sparing surgery. (Source: International Braz J Urol)

[Breast carcinoma metastasis into a renal cell carcinoma].

Annales de Pathologie — Sat, 01 Oct 2011 04:00:00 +0100

We report the case of a patient carrying a right breast carcinoma whose imaging exams showed lung and bone metastasic release, and incidentally synchronous right renal tumor. Histologic examination of the renal tumor found a mammary carcinoma metastasis into a clear renal cell carcinoma. This is the second case report of breast cancer with metastasis in a resected renal clear cell carcinoma. PMID: 21982250 [PubMed - in process] (Source: Annales de Pathologie)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Metastases in the mandible: clear cell carcinoma of a horseshoe kidney

International Journal of Oral and Maxillofacial Surgery — Sat, 01 Oct 2011 04:00:00 +0100

Man 60 years of age, smoker of 20 cigarettes a day for 15 years, with no other background at the time of the consultation. The review stomatological intraoral, reveals tumor in molar region left mandibular, with a rounded form, that measured 4cm×3cm, base sessile, coated with mucosa with ulcerated areas. Malignant tumors of the oral cavity and jawbones are approximately 5% of malignant neoplasms, only 1% have been considered metastasis. The majority of metastases in the jaw are diagnosed between the fifth and seventh decades of life, and the anatomic site of the primary carcinoma differs between the genres. In women the first in terms of frequency is breast carcinoma and in men the lung. The low frequency of metastases in maxillary bones of renal cell carcinomas clear cell and even more o...

Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types.

Gynecologic Oncology — Mon, 26 Sep 2011 04:00:00 +0100

CONCLUSION: This study suggests that CCC patients other than those with intraoperative capsule rupture show a considerable risk for mortality despite adjuvant chemotherapy. PMID: 21955484 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Evaluation of Renal Masses With Contrast-Enhanced Ultrasound: Initial Experience

American Journal of Roentgenology — Wed, 21 Sep 2011 04:00:00 +0100

CONCLUSION. Ultrasound features of gray-scale heterogeneity, lesion washout, grade of contrast enhancement, and quantitative measure of peak intensity may be useful for differentiating clear cell carcinoma and non–clear cell renal tumors. (Source: American Journal of Roentgenology)

iASPP and Chemoresistance in Ovarian Cancers - Effects on Paclitaxel-Mediated Mitotic Catastrophe.

Clinical Cancer Research — Fri, 16 Sep 2011 04:00:00 +0100

CONCLUSIONS: Our data demonstrate an association of iASPP overexpression with gene amplification in ovarian cancer and suggest a role of iASPP in poor patient outcome and chemoresistance, through blocking mitotic catastrophe. iASPP should be explored further as a potential prognostic marker and target for chemotherapy. PMID: 21926165 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Ovarian clear cell carcinoma—bad endometriosis or bad endometrium?

The Journal of Pathology — Thu, 08 Sep 2011 04:46:10 +0100

AbstractIt has become increasingly clear that the four main histological subtypes of epithelial ovarian cancer (EOC), high‐grade serous, endometrioid, clear cell and mucinous, are entities with different epidemiologies, clinical presentations, responses to treatment, and ultimate outcomes. In fact, for all intents and purposes, they can be considered different diseases, their only common denominator being that they frequently involve the ovary and pelvic organs. However, clinical practice has not caught up with these insights and the treatment of EOC is that of a single disease entity. In part, this is because we lack detailed knowledge of the molecular mechanisms driving the pathogenesis of each disease, which is vital in order to develop therapeutic approaches against common driver eve...

MedWorm Sponsor Message: Find the best January Sales in the UK.

An Unusual Case of Locally Advanced Glycogen-Rich Clear Cell Carcinoma of the Breast

Karger Publishers — Tue, 06 Sep 2011 17:29:20 +0100

Case Rep Oncol 2011;4:452–457 (DOI:10.1159/000332044) (Source: Karger Publishers)

RNA‐binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours

Histopathology — Thu, 01 Sep 2011 04:00:00 +0100

Conclusions: LIN28 is a sensitive marker for gonadoblastomas, dysgerminomas, ECs, and YSTs. LIN28 can be used to distinguish them from non‐GCTs. (Source: Histopathology)

Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma

Cancer — Mon, 22 Aug 2011 23:00:00 +0100

CONCLUSIONS:The authors concluded that increased EGFR expression occurs in a fraction of patients who have RCC with an unfavorable histologic phenotype. EGFR copy number gain represents 1 possible cause for EGFR overexpression; however, many over expressing tumors have a normal genotype. High polysomy (which is suggested to be predictive of a response to tyrosine kinase inhibitors) occurs in 5.6% of RCCs. Thus, the potential utility of anti‐EGFR medications may be worth further investigation in a small but significant subset of patients with RCC. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

Clinical Pathologic Conference Case 4: Hylanizing Clear Cell Carcinoma

Head and Neck Pathology — Mon, 22 Aug 2011 15:57:33 +0100

Content Type Journal ArticleCategory American Academy of Oral and Maxillofacial Pathology 65th Annual Meeting, San Juan, Puerto RicoPages 1-5DOI 10.1007/s12105-011-0292-9Authors Darren Cox, Department of Pathology and Medicine, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94115, USAChristel Haberland, Pediatric Dentistry, Yale-New Haven Hospital, Hamden, CT 06514, USA Journal Head and Neck PathologyOnline ISSN 1936-0568Print ISSN 1936-055X (Source: Head and Neck Pathology)

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation [Vascular and Interventional Radiology]

Radiology — Mon, 15 Aug 2011 23:00:00 +0100

Conclusion: Percutaneous thermal ablation of renal tumors occurring in renal grafts is effective, with low morbidity. © RSNA, 2011 (Source: Radiology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Alpha‐fetoprotein producing ovarian clear cell carcinoma with a neometaplasia to hepatoid carcinoma arising from endometriosis: A case report

Journal of Obstetrics and Gynaecology Research — Mon, 08 Aug 2011 23:00:00 +0100

In conclusion, the patient had a clear cell ovarian carcinoma with hepatoid carcinoma arising clearly from endometriosis. The recurrent tumors did not show a component of hepatoid carcinoma. Therefore, it is possible to expect better survival with good sensitivity to chemotherapy. (Source: Journal of Obstetrics and Gynaecology Research)

Biopsy‐confirmed de novo renal cell carcinoma (RCC) in renal grafts: a single‐centre management experience in a 2396 recipient cohort

BJU International — Mon, 01 Aug 2011 23:00:00 +0100

CONCLUSIONS• Our findings support evidence that radiological screening of kidney recipients allows the detection of small tumours for which a conservative management by NSS or non‐surgically destructive techniques can be proposed with mid‐term oncological safety.• Systematic tumour biopsy may help in the management and treatment decision.• Several questions remain unanswered such as the importance of mammalian target of rapamycin inhibitors in the chemoprevention of the recurrence and the genetic cell origin of RCC in renal grafts. (Source: BJU International)

Spherule‐like acellular stroma in clear cell carcinoma of the ovary: its utility in frozen section diagnosis

Histopathology — Mon, 01 Aug 2011 04:00:00 +0100

(Source: Histopathology)

Laparoscopic partial nephrectomy for T1a renal tumors is safe and feasible.

Chinese Medical Journal — Mon, 01 Aug 2011 04:00:00 +0100

CONCLUSIONS: LPN for pT(1) stage renal tumor was safe and feasible. Hem-o-lok instead of traditional ligature to clamp the suture when sewing the renal wound could shorten the warm ischemia time. PMID: 21933551 [PubMed - in process] (Source: Chinese Medical Journal)

Clear Cell Carcinoma of the Endometrium Causing Paraneoplastic Retinopathy: Case Report and Review of the Literature

Infectious Diseases in Obstetrics and Gynecology — Fri, 29 Jul 2011 16:20:24 +0100

We reviewed the literature for cases in which gynecologic malignancies caused paraneoplastic retinopathy and ultimately led to blindness. Twenty-eight cases were derived from the literature, and one unique case is described from our institution. Of these 28 cases, 14 patients were diagnosed with endometrial cancer, 7 with ovarian cancer, 5 with cervical cancer, 1 fallopian tube cancer and 1 with concomitant endometrial and ovarian cancers. The average age of patients at the time of diagnosis was 64 years (range, 35–89 years). Typically, ocular manifestations antedate symptoms of the underlying carcinoma by 3–12 months. Information regarding the interval from visual symptoms to time of death is limited, but ranges from several months to several years. Our report is the first to ...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Ovarian clear cell carcinoma as a stress-responsive cancer: Influence of the microenvironment on the carcinogenesis and cancer phenotype

Cancer Letters — Thu, 28 Jul 2011 23:00:00 +0100

Highlights: ► Ovarian endometriosis is known to transform into ovarian cancer, but its etiology is not clarified. ► A stressful microenvironment within the endometriotic cyst may lead to cancer development. ► Ovarian clear cell carcinoma has unique gene expressions, which may serve as a molecular marker. ► Carcinogenic microenvironment affects the phenotype, character and gene expression of a cancer. ► We might be able to develop new treatment based on the analysis of the influence of microenvironment.Abstract: Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometr...

Ovarian clear cell carcinoma ‐ Bad endometriosis or bad endometrium?

The Journal of Pathology — Mon, 18 Jul 2011 23:00:00 +0100

AbstractIt has become increasingly clear that the four main histologic subtypes of epithelial ovarian cancer (EOC), high‐grade serous, endometrioid, clear cell and mucinous, are entities with different epidemiology, clinical presentation, response to treatment and ultimate outcomes. In fact, for all intents and purposes, they can be considered different diseases; their only common denominator being that they frequently involve the ovary and pelvic organs. However, clinical practice has not caught up with these insights and the treatment of EOC is that of a single disease entity. In part, this is because we lack detailed knowledge of the molecular mechanisms driving the pathogenesis of each disease, which are vital in order to develop therapeutic approaches against common driver events. I...

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation [Vascular and Interventional Radiology]

Continuous Publishing articles — Mon, 18 Jul 2011 23:00:00 +0100

Conclusion: Percutaneous thermal ablation of renal tumors occurring in renal grafts is effective, with low morbidity. © RSNA, 2011 (Source: Continuous Publishing articles)

Cytoplasmic Staining of TTF-1 Antibody in the Diagnosis of Hepatocellular Carcinoma: Study on 299 Cases Using Tissue Microarray

Advances in Pharmacological Sciences — Wed, 06 Jul 2011 14:50:08 +0100

The diagnosis of hepatocellular carcinoma (HCC) remains obscure in some complicated cases. Thyroid transcription factor-1 (TTF-1) was presumed to be helpful in the diagnosis of HCC. This paper aims to study the utility of TTF-1 in the diagnosis and differential diagnosis of HCC and to assign clinicopathological correlations. Immunohistochemical detection of TTF-1 is performed with tissue microarray which contains a total of 781 cases including 299 hepatocellular carcinomas (HCCs), 31 intrahepaticcholangiocarcinomas (ICCs), 86 metastatic adenocarcinomas (MACs), 5 metastatic hepatocellular carcinomas (mHCCs), 9 hepatoblastomas (HBs), 40 renal clear cell carcinomas (RCCs), 215 adjacent nonneoplastic hepatic tissue, and 96 normal hepatic tissue. The result shows that TTF-1 is positive in 55.2%...

Combined Functional Genome Survey of Therapeutic Targets for Clear Cell Carcinoma of the Kidney

Japanese Journal of Clinical Oncology — Wed, 29 Jun 2011 23:00:00 +0100

Conclusions Through a combination of genome-wide expression and functional assays, we identified a set of genes with high potential as targets for drug development. This method is rapid and comprehensive and could be applied to the discovery of diagnostic biomarkers and therapeutic targets for cancers other than clear cell renal cell carcinoma. (Source: Japanese Journal of Clinical Oncology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis

Archives of Gynecology and Obstetrics — Wed, 29 Jun 2011 10:52:48 +0100

Conclusion In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management. Content Type Journal ArticlePages 1-5DOI 10.1007/s00404-011-1957-zAuthors A. Kondi-Pafiti, Pathology Laboratory, University of Athens, Athens, GreeceE. Papakonstantinou, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Iavazzo, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofias Ave, 11528 Athens, GreeceC. Grigoriadis, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 76 Vas.Sofi...

Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm

Human Pathology — Sat, 18 Jun 2011 23:17:13 +0100

Summary: Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer based on a dualistic model of carcinogenesis that divides epithelial ovarian cancer into 2 broad categories designated types I and II. Type I tumors comprise low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas, and Brenner tumors. They are generally indolent, present in stage I (tumor confined to the ovary), and are characterized by specific mutations, including KRAS, BRAF, ERBB2, CTNNB1, PTEN, PIK3CA, ARID1A, and PPP2R1A, which target specific cell signaling pathways. Type I tumors rarely harbor TP53 mutations and are relatively stable genetically. Type II tumors comprise high-gra...

The pathogenesis of endometrial carcinomas at menopause: facts and figures

Journal of Clinical Pathology — Wed, 15 Jun 2011 23:00:00 +0100

Almost a third of the life of a woman is now postmenopausal, and during this period over 80% of endometrial carcinomas develop. This is by far the most common gynaecological malignancy in the industrialised world and, probably, the less completely understood with regard to its pathogenesis after the menopause. For while it is generally thought that these neoplasms are non-oestrogen-induced, we are, at the same time, informed that oestrogenic stimulation is continuous during menopause through increases to oestrone formation in the adipose tissue from androgens of adrenal and ovarian origin. Furthermore, the postmenopausal endometrium has been typified as atrophic, which is indeed true, but is also implied as being inactive, which in fact it is not; in most cases, the postmenopausal endometr...

Hyalinizing clear cell carcinoma: A case report and review of the literature

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Mon, 13 Jun 2011 16:57:28 +0100

We present a case of HCCC affecting the upper vestibule in a 53-year-old man. The patient was treated by surgery and postoperative radiation and did not show recurrence or distant metastases 3 years after treatment. Discussed also are the clinical and pathologic features of this tumor along with the differential diagnosis and a literature review. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Glypican‐3 could be an effective target for immunotherapy combined with chemotherapy against ovarian clear cell carcinoma

Cancer Science — Thu, 09 Jun 2011 23:00:00 +0100

SummaryGlypican‐3 (GPC3) is useful not only as a novel tumor marker, but also as an oncofetal antigen for immunotherapy. We recently established HLA‐A2‐restricted GPC3144‐152 peptide‐specific CTL clones from hepatocellular carcinoma (HCC) patients after GPC3144‐152 peptide vaccination. The present study was designed to evaluate the tumor reactivity of HLA‐A2‐restricted GPC3144‐152 peptide‐specific CTL clone against ovarian clear cell carcinoma (CCC) cell lines. The GPC3144‐152 peptide‐specific CTL clone could recognize HLA‐A2‐positive and GPC3‐positive ovarian CCC cell lines on IFN‐γ ELISPOT assay and showed cytotoxicity against KOC‐7c cells. The CTL clone recognized naturally processed GPC3‐derived peptide on ovarian CCC cells in an HLA‐class‐Irest...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: Cytoplasmic sequestration of CDK2 by p27.

Gynecologic Oncology — Sun, 05 Jun 2011 23:00:00 +0100

CONCLUSIONS: Reduced CDK2 activity via the cytoplasmic sequestration of CDK2 by p27(Thr157) may contribute to suppression of CCC proliferation. A prospective study is needed to determine whether the cytoplasmic sequestration of CDK2 results in the chemoresistance of CCC. PMID: 21652059 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis.

Gynecologic Oncology — Tue, 31 May 2011 23:00:00 +0100

CONCLUSION: This analysis suggests that ovarian CCC patients had poorer prognosis than those with other histological subtypes of EOC, especially in advanced EOC stages. Different treatment strategies may be needed for patients with ovarian CCC. PMID: 21640372 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Clinical genomics of renal epithelial tumors

Cancer Genetics and Cytogenetics — Tue, 31 May 2011 23:00:00 +0100

Kidney and upper urinary tract cancers account for approximately 54,000 cases every year in the United States, and represent about 3.7% of adult malignancies, with more than 13,000 annual deaths. Classification of renal tumors is typically based on histomorphologic characteristics but, on occasion, morphologic characteristics are not sufficient. Each of the most common histologic subtypes harbors specific recurrent genetic abnormalities, such as deletion of 3p in conventional clear cell carcinoma, trisomy 7 and 17 in papillary renal cell carcinoma, multiple monosomies in chromophobe renal cell carcinoma, and a nearly diploid genome in benign oncocytomas. Knowledge of this information can provide diagnostic support and prognostic refinement in renal epithelial tumors. Identification of the ...

The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary.

Clinical Cancer Research — Thu, 26 May 2011 23:00:00 +0100

CONCLUSIONS: Trabectedin is a promising agent for CCC as a first-line chemotherapy and as a second-line treatment for recurrent CCC that had previously been treated with cisplatin or paclitaxel. Moreover, trabectedin combined with everolimus may be more efficacious for the management of CCC. PMID: 21622721 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment [Women's Imaging]

Radiographics recent issues — Wed, 11 May 2011 23:00:00 +0100

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a heterogeneous disease with several histologic subtypes that show characteristic cytogenetic features, molecular signatures, oncologic signaling pathways, and clinical-biologic behavior. Recent advances in histopathology and cytogenetics have provided insights into pathophysiologic features and natural history of OECs. Several studies have shown that high- or low-grade serous, endometrioid, and clear cell carcinomas are characterized by mutations involving the TP53, K-ras/BRAF, CTNNB1, and PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelomic spread of disease beyond the ovaries, whereas low-grade serous and mucinous carcinomas commonly manifest w...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Cytohistological study of clear cell carcinoma of kidney with special reference to nuclear grading and tumor size

Diagnostic Cytopathology — Tue, 10 May 2011 23:00:00 +0100

AbstractSeveral prognostic indicators have shown to predict patients' survival in clear cell carcinoma of kidney. Among these, Fuhrman nuclear grading and tumor size are believed to be two important prognostic factors. The aim of this study was to evaluate the efficacy of fine needle aspiration cytology (FNAC) to classify the clear cell renal cell carcinoma (CRCC) according to nuclear grade and tumor size. A total of 24 patients (15 males, 9 females) suffering from CRCC were included in this study over a period of 5 years (January, 2005 to December, 2009). A preoperative cytologic diagnosis was made by computed tomography guided FNAC and histologic correlation was made after surgery. Cytologic diagnoses were nuclear grade 1 or G1 (four cases), nuclear grade 2 or G2 (11 cases), nuclear grad...

Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma

International Journal of Cancer — Tue, 03 May 2011 23:00:00 +0100

AbstractRenal clear cell carcinoma (RCCC) is the most frequent subpopulation of renal cell carcinoma and is derived from the proximal uriniferous tubules. We have previously reported that an actin‐binding protein, 4.1B/DAL‐1, is expressed in renal proximal tubules, whereas it is inactivated in 45% of RCCC by promoter methylation. In the lung and several epithelial tissues, 4.1B is shown to associate with a tumor suppressor protein, CADM1, belonging to the immunoglobulin‐superfamily cell adhesion molecules. Here, we demonstrate by immunohistochemistry that another member of the CADM‐family protein, CADM4, as well as 4.1B is expressed specifically in human proximal tubules, while CADM1 and 4.1N, another member of the 4.1 proteins, are expressed in the distal tubules. Immunoprecipitat...

Adnexal clear cell carcinoma with comedonecrosis.

Archives of Pathology and Laboratory Medicine — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Woods MT, Garib GG, Andea AA PMID: 21526948 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Impact of Adjuvant External-Beam Radiation Therapy in Early-Stage Uterine Papillary Serous and Clear Cell Carcinoma

International Journal of Radiation Oncology * Biology * Physics — Tue, 19 Apr 2011 04:00:00 +0100

Conclusion: In FIGO Stage IB–C papillary serous and clear cell uterine carcinoma, adjuvant RT seems to play an important role in improving survival. (Source: International Journal of Radiation Oncology * Biology * Physics)

Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma

Modern Pathology AOP — Thu, 14 Apr 2011 23:00:00 +0100

Authors: Elisabetta Kuhn, Alan K Meeker, Kala Visvanathan, Amy L Gross, Tian-Li Wang, Robert J Kurman & Ie-Ming Shih (Source: Modern Pathology AOP)

MedWorm Sponsor Message: Find the best January Sales in the UK.

[Hyalinizing clear cell carcinoma of the maxilla.]

Revue de Stomatologie et de Chirurgie Maxillo-Faciale — Wed, 13 Apr 2011 23:00:00 +0100

We report a very rare maxillary localization. CASE REPORT: A 48-year-old male patient, without prior medical history, was referred to us for a painless gingival lesion of the right maxilla, extending from tooth 14 to 17, having appeared a few months before. The clinical examination was otherwise normal. Biopsy proved the diagnosis of HCCC. The CT scan revealed extension in maxillary sinus with bone osteolysis, and suspicion of cervical lymph nodes metastasis. The treatment was subtotal maxillectomy, cervical lymph node dissection, and postoperative radiotherapy because of incomplete bony resection. DISCUSSION: HCCC localization in the maxilla is extremely rare. This tumor may recur. The risk of metastasis is low; it concerns mainly lymph nodes. There is no treatment protocol consensus beca...

Low-Grade Clear Cell Carcinoma with Myoepithelial Features in the Submandibular Gland

Indian Journal of Otolaryngology and Head and Neck Surgery — Sat, 02 Apr 2011 05:56:57 +0100

Abstract Clear cell carcinoma is rarely found in the salivary gland. It is classified as a low-grade carcinoma. This case demonstrates a low-grade clear cell carcinoma with myoepithelial features in the submandibular gland which differs from hyalinizing clear cell carcinoma and epithelial-myoepithelial carcinoma. A 32-year-old man presented with a 7 month history of left submandibular swelling. Left submandibular gland excision and left-sided supra-omohyoid neck dissection were performed. Microscopically, the tumor was circumscribed and composed predominantly of cords and nests of clear ovoid cells, set in a densely hyalinizing stroma. These cells are diffusely immunoreactive for cytokeratin AE1/AE3 and focally reactive for vimentin and smooth muscle actin (SMA). Base...

Exploring palliative treatment outcomes in women with advanced or recurrent ovarian clear cell carcinoma.

Gynecologic Oncology — Fri, 01 Apr 2011 23:00:00 +0100

CONCLUSION.: Most patients with advanced or recurrent CCC have a low benefit-to-failure ratio from palliative CT. The role of RT and targeted agents must be explored to improve clinical outcomes for such patients. PMID: 21463887 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Loss of BAF250a ( ARID1A) is frequent in high‐grade endometrial carcinomas

The Journal of Pathology — Thu, 31 Mar 2011 23:00:00 +0100

AbstractMutation of the ARID1A gene and loss of the corresponding protein BAF250a has recently been described as a frequent event in clear cell and endometrioid carcinomas of the ovary. To determine whether BAF250a loss is common in other malignancies, immunohistochemistry (IHC) for BAF250a was performed on tissue microarrays (TMAs) in more than 3000 cancers, including carcinomas of breast, lung, thyroid, endometrium, kidney, stomach, oral cavity, cervix, pancreas, colon, and rectum, as well as endometrial stromal sarcomas, gastrointestinal stromal tumours, sex cord‐stromal tumours and four major types of lymphoma (diffuse large B‐cell lymphoma, primary mediastinal B‐cell lymphoma, mantle cell lymphoma, and follicular lymphoma). We found BAF250a loss is frequent in endometrial carcin...

Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas.

The American Journal of Pathology — Thu, 31 Mar 2011 23:00:00 +0100

Authors: Shih IeM, Panuganti PK, Kuo KT, Mao TL, Kuhn E, Jones S, Velculescu VE, Kurman RJ, Wang TL Exome sequencing of ovarian clear-cell carcinoma has identified somatic mutations in PPP2R1A, a subunit of protein phosphatase 2A. The present study was performed to determine the frequency of PPP2R1A mutations in exon 5, which harbors previously reported mutation hot spots, and adjacent exon 6, in 209 ovarian and 56 uterine tumors of various histologic subtypes. PPP2R1A mutations were demonstrated in 10 of 110 type I ovarian tumors (9.1%) including low-grade serous, low-grade endometrioid, clear-cell, and mucinous carcinomas. In contrast, none of 71 type II ovarian (high-grade serous) carcinomas exhibited PPP2R1A mutations. Moreover, PPP2R1A mutations were observed in 2 of 30 type I ute...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Loss of BAF250a (ARID1A) is frequent in high‐grade endometrial carcinomas

The Journal of Pathology — Thu, 31 Mar 2011 23:00:00 +0100

AbstractMutation of the ARID1A gene and loss of the corresponding protein BAF250a has recently been described as a frequent event in clear cell and endometrioid carcinomas of the ovary. To determine whether BAF250a loss is common in other malignancies, immunohistochemistry (IHC) for BAF250a was performed on tissue microarrays (TMAs) in more than 3000 cancers, including carcinomas of breast, lung, thyroid, endometrium, kidney, stomach, oral cavity, cervix, pancreas, colon and rectum, as well as endometrial stromal sarcomas, gastrointestinal stromal tumours, sex cord‐stromal tumours and four major types of lymphoma (diffuse large B cell lymphoma, primary mediastinal B cell lymphoma, mantle cell lymphoma and follicular lymphoma). We found that BAF250a loss is frequent in endometrial carcino...

Inactivation of O6‐methyguanine‐DNA methyltransferase by promoter hypermethylation: Association of epithelial ovarian carcinogenesis in specific histological types

Journal of Obstetrics and Gynaecology Research — Wed, 30 Mar 2011 23:00:00 +0100

Conclusions: Negative MGMT expression was significantly correlated with MGMT promoter hypermethylation in MSS‐phenotyped tumors of mucinous or clear cell carcinoma. The results suggest that MGMT promoter hypermethylation might be associated with epithelial ovarian carcinogenesis in specific histological types. (Source: Journal of Obstetrics and Gynaecology Research)

Clear cell carcinoma of the major salivary glands in an HIV-infected patient

International Journal of Oral and Maxillofacial Surgery — Thu, 17 Mar 2011 00:00:00 +0100

Abstract: Clear cell carcinoma is a rare type of salivary gland carcinoma. It has a low degree of malignancy and long-term prognosis is favourable after surgical removal. The authors describe the case of a human immunodeficiency virus (HIV) infected 43-year-old woman who presented with a tumour on the floor of the mouth. After biopsy, left suprahyoid lymph node dissection and removal of the submandibular and sublingual glands was performed, followed by radiotherapy. Histologically, the tumour presented the characteristic features of hyalinizing clear cell carcinoma, defined as a variant of clear cell carcinoma by the latest World Health Organization classification. Hyalinizing clear cell carcinoma has a characteristic histological pattern and, to date, there is insufficient information to ...

Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas.

Clinical Breast Cancer — Tue, 15 Mar 2011 00:00:00 +0100

CONCLUSIONS: OCCCs constitute a heterogeneous disease at the genomic level despite having similar histological features. The pattern of genomic aberrations in subgroups of OCCCs is of clinical significance. We have identified recurrently amplified regions that may harbor potential therapeutic targets for subgroups of OCCCs. Clin Cancer Res; 17(6); 1521-34. ©2011 AACR. PMID: 21411445 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)

Correlation between hyaluronic acid, hyaluronic acid synthase and human renal clear cell carcinoma

Chinese Journal of Cancer Research — Sat, 12 Mar 2011 06:52:26 +0100

Conclusion Different from other malignancy, HA and HASs (except for HAS3) may not play important roles in the biological progress of human RCCC. Content Type Journal ArticlePages 59-63DOI 10.1007/s11670-011-0059-6Authors Jian-liang Cai, Peking University Wu Jieping Urological Center, Peking University Shougang Hospital, Beijing, 100144 ChinaMing Li, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Urology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, 100142 ChinaYan-qun Na, Peking University Wu Jieping Urological Center, Peking University Shougang Hospital, Beijing, 100144 China Journal Chinese Journal of Cancer ResearchOnline ISSN 1993-0631Print ISSN 1000-9604 Journal...

MedWorm Sponsor Message: Find the best January Sales in the UK.

RET protein expression in papillary renal cell carcinoma.

Urologic Oncology — Wed, 09 Mar 2011 00:00:00 +0100

CONCLUSIONS:: RET protein may be contributing in part to an adaptation of a papillary growth pattern in certain renal malignancies. Given the possible therapeutic benefit of small molecule inhibitors of RET activation, further work needs to be done to highlight the functional relevance of RET protein expression in papillary RCC. PMID: 21396847 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Typing of ovarian carcinomas: an update

Diagnostic Histopathology — Mon, 07 Mar 2011 00:00:00 +0100

Abstract: Classification of ovarian carcinomas into different subtypes is no longer only an exercise in pattern recognition that lacks clinical and biological significance. Biologically validated diagnostic criteria now separate ovarian carcinomas into specific disease types that have clinical relevance: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, clear cell carcinoma and primary ovarian mucinous carcinoma. This review summarizes the clinical and pathologic features of these types of ovarian carcinoma and provides information about refined diagnostic criteria and the use of ancillary diagnostic techniques for diagnosis. (Source: Diagnostic Histopathology)

Primary clear cell carcinoma of the liver with intracerebral hemorrhage as first presentation: case report.

Onkologie — Thu, 03 Mar 2011 03:45:04 +0100

Authors: Zhou H, Lv L, Ding X PMID: 21346386 [PubMed - in process] (Source: Onkologie)

High-Grade Endometrial Carcinomas

Surgical Pathology Clinics — Tue, 01 Mar 2011 00:00:00 +0100

Abstract: High-grade endometrial carcinomas are a heterogeneous group of clinically aggressive tumors. They include FIGO grade 3 endometrioid carcinoma, serous carcinoma, clear cell carcinoma, undifferentiated carcinoma, and malignant mixed Müllerian tumor (MMMT). Epidemiologic, genetic, biologic prognostic and morphologic differences between these entities are striking in prototypic cases, yet substantial overlap exists and diagnostic criteria and therapeutic approaches that account for the group's diversity are currently insufficient. FIGO grade 3 endometrioid carcinoma demonstrates solid, trabecular or nested growth and may resemble poorly differentiated squamous cell carcinoma. Endometrioid glandular differentiation is usually focally present. Serous carcinoma usually displays papilla...

Molecular Pathology of Ovarian Carcinomas

Surgical Pathology Clinics — Tue, 01 Mar 2011 00:00:00 +0100

Abstract: This content presents a review of molecular pathology of ovarian cancer. The authors present key molecular features for high-grade and low-grade serous carcinomas, endometrioid carcinomas, clear cell carcinomas, and mucinous carcinomas. Cell lineage, mutation and gene expression, pathway alterations, risk factors, prognostic markers, and treatment targets are discussed. (Source: Surgical Pathology Clinics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Secretory carcinoma of the endometrium: An unusual pattern

Basic and Applied Pathology — Tue, 01 Mar 2011 00:00:00 +0100

We report a case of secretory carcinoma endometrium in a 42‐year‐old woman presenting with irregular vaginal bleeding and underwent a hysterectomy revealing secretory carcinoma endometrium. The histological features of secretory carcinoma are reminiscent of normal early secretory endometrium (17–22 days), displaying a well differentiated glandular pattern having columnar cells with subnuclear or supranuclear vacuolization containing clear glycogenated cytoplasm. It is extremely important to distinguish secretory carcinoma from clear cell carcinoma in view of the excellent prognosis of the former and the unfavorable prognosis of the latter. (Source: Basic and Applied Pathology)

[Nephron-sparing surgery for clear cell carcinoma in a solitary functional kidney. Case report and literature review.]

Cirugia y Cirujanos — Tue, 01 Mar 2011 00:00:00 +0100

Conclusions: Open nephron-sparing surgery has been the standard treatment for small renal masses with peripheral localization; however, in specific cases with deteriorated renal function and tumors >5 cm close to the renal hilum, certain risk must be taken in order to perform this procedure that has proven to be highly effective in preserving renal function. Open nephronsparing surgery represents a highly effective procedure in small renal masses with a nonfunctional contralateral kidney. PMID: 21631983 [PubMed - as supplied by publisher] (Source: Cirugia y Cirujanos)

Occult renal cell carcinoma manifesting with epistaxis in a woman: a case report

BioMed Central — Thu, 24 Feb 2011 00:00:00 +0100

Conclusions: General practitioners and ear, nose and throat (ENT) doctors are very often confronted with epistaxis. A small minority of patients with epistaxis show a primary or metastatic nasal mass. Detection of the origin of secondary sinonasal masses requires a high index of suspicion and examination of infraclavicular sites by a multidisciplinary team. Renal cell carcinoma metastases are prone to severe bleeding during any surgical intervention, therefore, preoperative embolization is recommended. Resection or radiotherapy to the sinonasal metastasis of renal origin is justified in order to prevent recurrent nosebleeds. (Source: BioMed Central)

Primary clear cell carcinoma in the liver: CT and MRI findings.

World Journal of Gastroenterology : WJG — Mon, 21 Feb 2011 00:00:00 +0100

Authors: Liu QY, Li HG, Gao M, Lin XF, Li Y, Chen JY To retrospectively analyze the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of primary clear cell carcinoma of the liver (PCCCL) and compare the imaging appearances of PCCCL and common type hepatocellular carcinoma (CHCC) to determine whether any differences exist between the two groups. PMID: 21412505 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy

European Journal of Cancer — Mon, 21 Feb 2011 00:00:00 +0100

Abstract: Advances in predicting responses to therapies in ovarian cancer have not matched progress seen in other solid-organ tumours: ovarian cancer remains a poor-prognosis disease. There has been a paradigm shift in molecular therapeutics away from targeting individual molecules to whole biological pathways. The aim of this study was to quantitatively measure the activation state of druggable oncogenic pathways by generating a phosphoprotein profile in cancer tissues, in order to establish associations with clinicopathological parameters and to identify treatment groups for targeted therapy. In total we analysed the expression of ten phosphoproteins within eight signalling pathways (PI3K, MAPK, β-catenin, STAT, NFκB, ER, cell cycle and DNA damage response), proliferation (phospho-hist...

MedWorm Sponsor Message: Find the best January Sales in the UK.

A case report of retroaortic left renal vein with tumor thrombus of renal cell carcinoma

Clinical and Experimental Nephrology — Wed, 16 Feb 2011 06:54:25 +0100

Abstract A 75-year-old woman was referred to our department for evaluation of a left renal tumor. Computed tomography and other imaging studies demonstrated a left renal mass and tumor extension into the left renal vein passing caudally behind the aorta. We clinically diagnosed the tumor as renal cell carcinoma (RCC) associated with a retroaortic left renal vein thrombus, and performed a radical nephrectomy. Pathological examination of the surgical specimen showed a grade 2, clear cell carcinoma with a renal vein thrombus and negative surgical margin. Retroaortic left renal vein is a rare anomaly with a prevalence of 1.8–2.4%. RCC associated with a retroaortic left renal vein thrombus is rarer still. To our knowledge, this is only the third case report to describe an RCC...

A rare case of renal and uterine clear cell carcinoma: Which is the primary tumour?

Central European Journal of Medicine — Fri, 11 Feb 2011 11:53:22 +0100

We describe a 52-year old lady who presented with progressive abdominal distension and computerized tomogram scan of the abdomen showing two pathologies; uterine and right renal tumour. It was initially thought to be two distinct tumours (double pathology). Radical nephrectomy and total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed concurrently. Histopathological evaluation of the uterine and right renal tumour however surprised us with a rare form of metastasis from a renal tumour to the uterus. The method of differentiating primary renal cell carcinoma with uterine metastasis, from primary uterine carcinoma with renal metastasis, via immunohistochemistry, is described. Content Type Journal ArticlePages 1-3DOI 10.2478/s11536-011-0008-2Authors Christ...

Hollow spheroids in ascites of ovarian clear cell carcinoma: how are they formed and how do they behave?

Cytopathology — Tue, 08 Feb 2011 00:00:00 +0100

Conclusions: The hollow space in the spheroids originates from spherule‐like hyaluronan‐rich stroma, where water trapping by hyaluronan causes enlargement of the space. The matrix within the hollow space serves as a scaffold that regulates cell polarity and matrix production. (Source: Cytopathology)

Nuclear P27 expression in benign, borderline (LMP) and invasive tumors of the ovary and its association with prognosis: A gynecologic oncology group study.

Gynecologic Oncology — Tue, 08 Feb 2011 00:00:00 +0100

CONCLUSIONS: Low p27 expression could be associated with malignant transformation of the ovarian epithelium and FIGO stage. A cyclin E to p27 ratio >1.0 may be associated with shorter survival in these patients. Further study is required to confirm the trend for increased recurrences with low p27 expression in early stage disease. PMID: 21310472 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Primary clear cell carcinoma of a paratubal cyst: A case report with literature review

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Mon, 07 Feb 2011 00:00:00 +0100

(Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Clear Cell Carcinoma and Clear Cell Odontogenic Carcinoma: a Comparative Clinicopathologic and Immunohistochemical Study

Head and Neck Pathology — Thu, 03 Feb 2011 21:13:03 +0100

In this study the clinicopathologic, histologic, and immunohistochemical features of 17 CCCs and 12 CCOCs are examined. The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated. Content Type Journal ArticlePages 1-7DOI 10.1007/s12105-011-0244-4Authors Elizabeth A. Bilodeau, Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, 3501 Terrace St, Pittsburgh, PA 15261, USAAaron P. Hoschar, Department of Pathology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44106, USAE. Leon Barnes, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA USAJennifer ...

Med Sci Monit 2011; 17(2):CS15-17 "Metastatic renal cell carcinoma diagnosed by capsule endoscopy and double balloon endoscopy"

Medical Science Monitor — Fri, 28 Jan 2011 20:04:28 +0100

Conclusions: CE and DBE are useful diagnostic tools. We recommend investigating the possibility of small intestinal metastases in cases of intestinal bleeding or anemia in patients with a history of malignant tumor. (Source: Medical Science Monitor)

Clinical and Prognostic Value of the Presence of Irregular Giant Nuclear Cells in pT1 Ovarian Clear Cell Carcinoma.

Pathology Oncology Research — Fri, 28 Jan 2011 00:00:00 +0100

Authors: Matsumoto N, Umezawa T, Sasaki T, Nakajima K, Kanetsuna Y, Sasaki H In the early stages of epithelial ovarian cancer, histopathological grading is important. However, the grading of ovarian clear cell carcinoma (OCCC) remains controversial. We aimed to identify irregular giant nuclear cells (IGNCs) by a simple method in clinical practice, and to evaluate the prognostic value of IGNCs in pT1 OCCC. Eighty-seven pT1 OCCC patients who underwent initial surgery at Jikei University Kashiwa Hospital, Chiba, Japan, were retrospectively assessed. Paraffin-embedded tissue sections (PTSs) stained with hematoxylin and eosin were reviewed. Giant nuclear cells (GNCs) were defined as cells with a nuclear length of more than twice the median nuclear length. GNCs with irregular nuclear circumf...

Renal cell carcinoma with metastases to the gallbladder: Four cases from the National Cancer Institute (NCI) and review of the literature.

Urologic Oncology — Fri, 28 Jan 2011 00:00:00 +0100

CONCLUSION: Gallbladder metastasis from RCC is a rare event that may occur synchronously or metachronously with most patients being asymptomatic. Clear cell carcinoma appears to be the primary pathology associated with gallbladder metastasis. High rates of bilateral RCC and pancreatic metastasis suggest novel associations in patients with RCC and gallbladder metastasis. PMID: 21277810 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Immunohistochemical expression of microvascular density and carbonic anhidrase IX in renal carcinoma. Relation to histological type and tumoral progression.

Actas Urologicas Espanolas — Thu, 20 Jan 2011 00:00:00 +0100

CONCLUSIONS: neither MVD nor CAIX expressions were related to tumour progression, but were related to histological subtypes. This fact, added to their co-expression, could prompt the use of the CAIX expression, which is far more reproducible, as a quick and easy approximation to MVD. More research should be done to use it as marker for targeted therapy. PMID: 21256634 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Nature AOP — Wed, 19 Jan 2011 00:00:00 +0100

Authors: Ignacio Varela, Patrick Tarpey, Keiran Raine, Dachuan Huang, Choon Kiat Ong, Philip Stephens, Helen Davies, David Jones, Meng-Lay Lin, Jon Teague, Graham Bignell, Adam Butler, Juok Cho, Gillian L. Dalgliesh, Danushka Galappaththige, Chris Greenman, Claire Hardy, Mingming Jia, Calli Latimer, King Wai Lau, John Marshall, Stuart McLaren, Andrew Menzies, Laura Mudie, Lucy Stebbings, David A. Largaespada, L. F. A.Wessels, Stephane Richard, Richard J. Kahnoski, John Anema, David A.Tuveson, Pedro A. Perez-Mancera, Ville Mustonen, Andrej Fischer, David J. Adams, Alistair Rust, Waraporn Chan-on, Chutima Subimerb, Karl Dykema, Kyle Furge, Peter J. Campbell, Bin Tean Teh, Michael R. Stratton & P. Andrew Futreal The genetics of renal cancer is dominated by inactivation of the VHL tumour s...

Weekly administration of temsirolimus for heavily pretreated patients with clear cell carcinoma of the ovary: a report of six cases

International Journal of Clinical Oncology — Mon, 17 Jan 2011 20:14:44 +0100

In conclusion, weekly TEM shows a potential therapeutic benefit for patients with CCC of the ovary. Further studies including a translational approach are needed to select candidates for whom TEM therapy would be beneficial. Content Type Journal ArticlePages 1-5DOI 10.1007/s10147-010-0177-zAuthors Masashi Takano, Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanYoshihiro Kikuchi, Department of Gynecology, Ohki Memorial Kikuchi Cancer Clinic for Women, Tokorozawa, Saitama 359-1133, JapanKazuya Kudoh, Department of Obstetrics and Gynecology, Nishisaitama-chuo National Hospital, Tokorozawa, Saitama 359-1151, JapanTomoko Goto, Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, T...

Risk Factors, Prognosis, and Management of Early and Late Intrahepatic Recurrence After Resection of Primary Clear Cell Carcinoma of the Liver

Annals of Surgical Oncology — Sat, 15 Jan 2011 06:58:14 +0100

Conclusion PCCCL has a better prognosis and tends to recur later than HCC. Early and late recurrences of PCCCL are linked to different predictive factors. The time to recurrence and feasibility of curative treatment are the best determinants for the prognosis. Content Type Journal ArticlePages 1-9DOI 10.1245/s10434-010-1540-zAuthors Tao Li, Department of General Surgery, Qilu Hospital, Shandong University, Jinan, ChinaJia Fan, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, ChinaLun-Xiu Qin, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, ChinaJian Zhou, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, ChinaHui-Chuan Sun, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, Chin...

2010 — November Case of the Month

CAP Case of the Month — Thu, 06 Jan 2011 16:25:00 +0100

A 60-year-old man presented with abdominal pain, constipation and melena. The patient underwent nephrectomy for clear cell carcinoma of the kidney 7 years ago. Colonoscopy revealed an ill-defined mass in the sigmoid colon with normal overlying mucosa. Abdominal CT showed a 4.0 cm hypervascular mass on the serosal aspect of the sigmoid colon. (Source: CAP Case of the Month)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Subtype specific mutation of PPP2R1A in endometrial and ovarian carcinomas

The Journal of Pathology — Wed, 05 Jan 2011 00:00:00 +0100

AbstractPPP2R1A mutations have recently been described in 3/42 (7%) of clear cell carcinomas of the ovary. PPP2R1A encodes the α isoform of the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) holoenzyme. This putative tumour suppressor complex is involved in growth and survival pathways. Through targeted sequencing of PPP2R1A we identified somatic missense mutations in 40.8% (20/49) of high‐grade serous endometrial tumours, and 5.0% (3/60) of endometrial endometrioid carcinomas. Mutations were also identified in ovarian tumours at lower frequencies: 12.2% (5/41) of endometrioid, and 4.1% (2/49) of clear cell carcinomas. No mutations were found in 50 high‐grade and 12 low‐grade serous carcinomas. Amino acid residues affected by these mutations are highly con...

Subtype‐specific mutation of PPP2R1A in endometrial and ovarian carcinomas

The Journal of Pathology — Wed, 05 Jan 2011 00:00:00 +0100

AbstractPPP2R1A mutations have recently been described in 3/42 (7%) of clear cell carcinomas of the ovary. PPP2R1A encodes the α‐isoform of the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) holoenzyme. This putative tumour suppressor complex is involved in growth and survival pathways. Through targeted sequencing of PPP2R1A, we identified somatic missense mutations in 40.8% (20/49) of high‐grade serous endometrial tumours, and 5.0% (3/60) of endometrial endometrioid carcinomas. Mutations were also identified in ovarian tumours at lower frequencies: 12.2% (5/41) of endometrioid and 4.1% (2/49) of clear cell carcinomas. No mutations were found in 50 high‐grade and 12 low‐grade serous carcinomas. Amino acid residues affected by these mutations are highly c...

Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior

Human Pathology — Wed, 05 Jan 2011 00:00:00 +0100

Summary: Ovarian clear cell carcinoma is found more often confined to the ovary (stage I) than high-grade serous carcinoma. The RHO GTPase family of proteins is involved in tumor invasion and metastasis through regulation of the cytoskeleton. The expression of several RHO family genes, including RHOA, RHOC, CDC42, and 3 ARHGDIs (Rho GDP dissociation inhibitors), was studied by real-time polymerase chain reaction in 22 clear cell carcinomas and 31 high-grade serous carcinomas. Immunoreaction for p21-activated kinase 1 (a downstream effector of CDC42) was also investigated on 6 tissue microarrays containing 76 carcinomas (13 clear cell carcinomas and 63 high-grade serous carcinomas). Eight clear cell carcinomas (8/21; 38%) were at stage I, whereas only 3 high-grade serous carcinomas (3/31; 1...

Contrast-enhanced endoscopic ultrasonography (CE-EUS) findings in adrenal metastasis from renal cell carcinoma

Journal of Medical Ultrasonics — Tue, 04 Jan 2011 17:52:48 +0100

We describe a solitary left adrenal gland mass in a patient who had undergone simultaneous gastrectomy and right nephrectomy for advanced gastric cancer and renal cell carcinoma (RCC), respectively. Contrast-enhanced endoscopic ultrasonography (CE-EUS) findings indicated a hypervascular adrenal mass, and EUS-guided fine needle aspiration (EUS-FNA) revealed clear cell carcinoma. Adrenalectomy confirmed metastatic clear cell carcinoma of the kidney. Content Type Journal ArticleDOI 10.1007/s10396-010-0297-0Authors Susumu Hijioka, Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanAkira Sawaki, Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, JapanNobumas...

Sarcomatoid renal cell carcinoma.

Saudi Journal of Kidney Diseases and Transplantation — Sat, 01 Jan 2011 00:00:00 +0100

We report a case of a 70-year-old male patient, who presented with acute left upper quadrant abdominal pain and was diagnosed to have SRCC after pathological examination. The patient is on high dose interleukin (IL-2)-based immunotherapy and is apparently free of disease six months after surgery. PMID: 21196626 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Hyalinizing clear cell carcinoma of the base of tongue: A distinct and rare entity.

Indian Journal of Pathology and Microbiology — Sat, 01 Jan 2011 00:00:00 +0100

We present a case of HCCC involving the base of tongue, in a 73-year-old male, clinically diagnosed as fibroma. Laser excision of the mass was done. Histopathological examination showed an infiltrating lesion composed predominantly of clear cells. The differential diagnosis included other salivary gland lesions having a clear cell component and metastatic clear cell renal carcinoma. Immunohistochemistry was useful in ruling out these lesions exhibiting clear cell component from clear cell carcinoma. Imaging studies revealed no lesion in either kidney. Since, HCCC has a better prognosis and the adequate treatment is wide excision, it needs to be differentiated from other carcinomas with clear cells. No further therapy was given to the patient. One year after the surgery, the patient is symp...

Disease-specific Survival in Patients with Renal Cell Carcinoma: An Audit of a Large Series from Korea

Japanese Journal of Clinical Oncology — Fri, 31 Dec 2010 00:00:00 +0100

Conclusions Tumours found in young adults show more favourable histological features than those found in older adults. However, according to results from multivariate analysis, young patients do not have higher disease-specific survival rate after adjusting for clinical and pathological variables. (Source: Japanese Journal of Clinical Oncology)

Classification of ovarian carcinomas based on pathology and molecular genetics

Clinical and Translational Oncology — Wed, 29 Dec 2010 17:05:55 +0100

Abstract Malignant epithelial tumours (carcinomas) are the most common ovarian cancers and the most lethal gynaecological malignancies. Based on light microscopy and molecular genetics, ovarian carcinomas are subdivided into at least five main subtypes that account for over 95% of cases and are inherently different diseases, as indicated by differences in epidemiological and genetic risk factors, precursor lesions, patterns of spread, molecular events during oncogenesis, response to chemotherapy and outcome. For successful subtype-specific treatment, reproducible pathological diagnosis of tumour cell type is critical. Recent investigations have also demonstrated that a significant number of cancers traditionally thought to be primary ovarian tumours (particularly serous, e...

A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib

International Journal of Clinical Oncology — Wed, 15 Dec 2010 15:52:33 +0100

We report a case of Xp11.2 translocation renal cell carcinoma (RCC) whose lung metastases were effectively treated with sunitinib. A 43-year-old woman presenting with upper abdominal pain was diagnosed with a left renal tumor. Laparoscopic left radical nephrectomy was performed. Histopathological examination of the surgical specimen revealed a clear-cell carcinoma of the left kidney. Two years later, multiple lung metastases were detected and the patient was treated daily with 50 mg sunitinib. A computed tomography scan performed after 2 cycles of sunitinib treatment revealed partial regression of these metastases. The partial regression has been maintained for >3 years. In retrospective evaluation of the primary RCC, tumor cells showed strong nuclear staining for transc...

New Insights of Pattern Recognition Receptors and Their Ligands in Gynecologic Pathologies.

Human Immunology — Tue, 14 Dec 2010 00:00:00 +0100

CONCLUSION: Recent advances in innate immunity illuminate the molecular mechanism underlying inflammation-induced carcinogenesis. Upregulation of PRRs expression may synergize with activation of HNF-1beta signaling to accelerate endometriosis proliferation and cause carcinogenesis. PMID: 21167248 [PubMed - as supplied by publisher] (Source: Human Immunology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Genetics of pheochromocytomas and paragangliomas

Best Practice and Research. Clinical Endocrinology and Metabolism — Wed, 01 Dec 2010 00:00:00 +0100

Pheochromocytoma and paraganglioma are tumors of the sympathetic or parasympathetic paraganglia. Pheochromocytoma is the tumor of the main sympathetic paraganglia, which is the adrenal medulla. The sympathetic paraganglioma secretes catecholamine while the parasympathetic do not. Both of them originate from neural crest cells and share similar mechanisms of tumor development. The same genetic alteration may predispose to the development of sympathetic and parasympathetic paraganglioma.The best known hereditary forms of pheochromocytoma and paraganglioma are the von Hippel–Lindau disease, in which pheochromocytoma may be associated with CNS hemangioblastoma, retinal angioma, pancreatic endocrine tumor/cysts and renal clear cell carcinoma/cysts; the multiple endocrine neoplasia type 2, i...

Natural history of renal cell carcinoma: a case with 18 years follow-up

Clinical and Experimental Nephrology — Tue, 30 Nov 2010 07:01:40 +0100

Abstract A 53-year-old woman presented to our hospital with a non-metastatic 4 cm renal mass in the right kidney. The patient rejected treatment, but consented to follow-up observation of her condition. The patient underwent a series of computed tomography scans to monitor the progression of the disease. We were able to observe not only an increase in renal mass size, but also involvement of para-aortic lymph nodes, inferior vena cava, and metastasis to the lung. Eighteen years after diagnosis, the subject was hospitalized and died as a result of complications of the disease. Autopsy showed the pathologic diagnosis of the renal mass to be a grade 2 clear cell carcinoma. The literature contains several papers that describe the natural history of renal masses and carcin...

Carbonic Anhydrase IX Expression in Renal Neoplasms: Correlation With Tumor Type and Grade.

American Journal of Clinical Pathology — Tue, 23 Nov 2010 23:36:14 +0100

Authors: Genega EM, Ghebremichael M, Najarian R, Fu Y, Wang Y, Argani P, Grisanzio C, Signoretti S Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma ha...

Editorial Comment

The Journal of Urology — Fri, 12 Nov 2010 00:00:00 +0100

In this study the presence of clear cells in PRCC was independently associated with aggressive pathological characteristics and poorer prognosis after nephrectomy. These clear cells had specific molecular characteristics, such as staining for CK7, AMACR and increased VEGF-R2, compared to clear cell carcinoma. Although findings are compelling, the biological significance of clear cells in at least 5% of tumor cells, the cutoff point used in this study, is not fully understood. No correlation was observed between the extent of clear cell involvement and pathological variables. Also, the incidence of PRCC with clear cells in this cohort was quite high at 39% and may not be representative what is observed in other practice settings. (Source: The Journal of Urology)

A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings

Cancer Immunology, Immunotherapy — Wed, 10 Nov 2010 17:22:11 +0100

Abstract MUC1 over-expression in renal clear-cell carcinoma (RCC) is associated with poor prognosis. This phase II study determined the efficacy and tolerability of TG4010, a cancer vaccine based on a modified vaccinia virus expressing MUC1 and interleukin-2, in combination with cytokines, as first-line therapy in metastatic RCC. Thirty-seven patients with progressive, MUC1-positive RCC received TG4010 108 pfu/inj weekly for 6 weeks, then every 3 weeks until progression, when TG4010 was continued in combination with interferon-α2a and interleukin-2. Assessments included clinical response (primary endpoint), safety, time to treatment failure (TTF), overall survival (OS), and immune response. No objective clinical responses occurred. Five of the 27 evaluable p...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Metastasis to scalp of clear cell carcinoma.

Actas Urologicas Espanolas — Mon, 01 Nov 2010 00:00:00 +0100

Authors: Navarrete-Gutiérrez G, Fuentes-Valencia A, Salaverría-Cáceres J, Vela-Jiménez G PMID: 21159302 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

Introduction

Seminars in Diagnostic Pathology — Mon, 01 Nov 2010 00:00:00 +0100

Several important conditions of the endometrium (non-neoplastic, preneoplastic, and neoplastic) will be discussed in this issue of Seminars in Diagnostic Pathology. Particular attention is given to precancerous lesions and experts in the field will highlight the advantages and disadvantages of using the traditional WHO classification system and the Endometrial Intraepithelial Neoplasia (EIN) concept. In addition, two articles will be devoted to the two main clinicopathological categories of endometrial carcinoma: type I (endometrioid carcinoma and their variants) and type II (namely serous and clear cell carcinoma). Because it is not uncommon in daily practice to encounter tumors with mixed features, we have included one chapter that discusses carcinomas exhibiting ambiguous morphologic, i...

Nonendometrioid endometrial carcinomas

Seminars in Diagnostic Pathology — Mon, 01 Nov 2010 00:00:00 +0100

Clinicopathologic studies support a classification of endometrial carcinoma into two main categories (type I and type II). Type I cancers consist of endometrioid and mucinous carcinomas, with the former being the most common, whereas serous and clear cell carcinomas are the so-called “prototype” of type II cancers. Nonendometrioid carcinomas account for approximately 10% of endometrial carcinomas and differ from endometrioid carcinomas in terms of patient demographics, morphologic features, and biological behavior. Molecular studies have provided further insights into the differing alterations involved in the development and progression of these tumors. This review summarizes the characteristic clinical, morphologic, immunophenotypic, and molecular features of the various subtypes of n...

von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas.

Clinical Cancer Research — Mon, 25 Oct 2010 23:00:00 +0100

CONCLUSIONS: Elevated PHD1 concomitant with decreased PHD2 are causatively related to Rpb1 hydroxylation and oncogenesis in human RCC tumors with WT VHL gene. Thus, P1465-hydroxylated Rpb1 and PHD1 represent attractive drug targets for new RCC treatments. Clin Cancer Res; 16(21); 5142-52. ©2010 AACR. PMID: 20978146 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary

Journal of Clinical Pathology — Fri, 22 Oct 2010 23:00:00 +0100

Conclusions Results suggest that the overexpression of GPC3 may be related to the low-level proliferation of tumours; it may be associated with resistance to taxane-based chemotherapy and a poor prognosis in CCC of the ovary. (Source: Journal of Clinical Pathology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Strong cytotoxic effect of the bradykinin antagonist BKM‐570 in ovarian cancer cells – analysis of the molecular mechanisms of its antiproliferative action

FEBS Journal — Fri, 22 Oct 2010 00:00:00 +0100

The standard chemotherapy for epithelial ovarian cancer (EOC) patients is currently a combination of taxane and platinum. However, most EOC patients still suffer relapses, and there is an immediate need for the development of novel and more effective therapeutic modalities against this deadly disease. Recently, the nonpeptide bradykinin (BK) antagonist 2,3,4,5,6‐pentafluorocinnamoyl‐(o‐2,6‐dichlorobenzyl)‐l‐tyrosine‐N‐(4‐amino‐2,2,6,6‐tetramethyl‐piperidyl) amide (BKM‐570) was shown to cause impressive growth inhibition of lung and prostate tumors, displaying superior in vivo inhibitory effects than convential chemotherapeutic drugs. Here, we investigated BKM‐570 cytotoxic effects in two EOC cell lines, derived from different EOC histopathologies: a clear cell...

Strength of molecular cytogenetic analyses for adjusting the diagnosis of renal cell carcinomas: a study of four cases with complete or hybrid morphology of clear cell carcinomas

Cancer Genetics and Cytogenetics — Sat, 16 Oct 2010 14:33:20 +0100

We present one other case, that of a 54-year-old patient, whose histology was characteristic of a CCC but whose karyotype, complemented with FISH, revealed a carcinoma with an Xp11.2 translocation. This type of chromosomal anomaly is usually seen in worse-prognosis RCC with papillary structures in children and young adults. Its incidence is, therefore, probably underestimated in adults because of the absence of systematic cytogenetic analysis of RCC. (Source: Cancer Genetics and Cytogenetics)

Occurrence of other tumors in patients with GIST

Surgical Oncology — Fri, 08 Oct 2010 20:03:42 +0100

Conclusions: We discovered a 13.8% incidence of non-GIST tumors in a series of 101 GIST cases under our care. This association should always be considered in the management of patients with GIST. (Source: Surgical Oncology)

[Report] Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

Science: Current Issue — Thu, 07 Oct 2010 20:34:35 +0100

Genetic analysis of a rare but aggressive form of ovarian cancer implicates a chromatin remodeling defect in disease development.Authors: Siân Jones, Tian-Li Wang, Ie-Ming Shih, Tsui-Lien Mao, Kentaro Nakayama, Richard Roden, Ruth Glas, Dennis Slamon, Luis A. Diaz Jr., Bert Vogelstein, Kenneth W. Kinzler, Victor E. Velculescu, Nickolas Papadopoulos (Source: Science: Current Issue)

Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling

Cancer Science — Thu, 30 Sep 2010 23:00:00 +0100

The purpose of this study was to investigate a new modality of therapy against ovarian clear cell carcinoma (OCCC), a chemoresistant subtype of ovarian cancer. Microarray datasets of ovarian cancer cell lines and cancer tissues were analyzed using bioinformatic tools. The gene expression profile of OCCC was similar to that of renal cell carcinoma (RCC). This similarity was at least partially due to hepatocyte nuclear factor 1 pathway activation common to both malignancies. In addition, oncogenic pathway alterations were characteristic of OCCC including hypoxia inducible factor 1 alpha subunit and relatively high Ras activities. Therefore, we predicted that the multi‐kinase inhibitor sorafenib, which is approved for RCC and suppresses Ras activity, would also be effective against OCCC. Or...

MedWorm Sponsor Message: Find the best January Sales in the UK.

MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

BMC Cancer — Thu, 16 Sep 2010 23:00:00 +0100

Background: The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods: Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results: MAL2 and TPD5...

Primary clear cell carcinoma of the nasopharynx: a case report

The Chinese-German Journal of Clinical Oncology — Thu, 16 Sep 2010 05:49:09 +0100

Abstract Primary clear cell carcinoma of the nasopharynx is a rare and locally invasive minor salivary gland neoplasm, only two cases have been reported yet in the literature. Now a 57-year man, with primary nasopharyngeal clear carcinoma, received radiotherapy and chemotherapy. After treatment, the mass of nasopharynx visibly reduced. Follow-up two months and repeated MRI, CT, abdominal B-ultrasonograpy, electronic nasopharyngoscopy, no tumor recurrence or metastasis. Content Type Journal ArticleDOI 10.1007/s10330-010-0611-8Authors Fangzheng Wang, Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou, 310022 ChinaZhenfu Fu, Department of Radiation Oncology, Zhejiang Tumor Hospital, Hangzhou, 310022 China Journal The Chinese-German Journal of Clini...

Cancer biology: Ovarian cancer culprits

Nature — Tue, 14 Sep 2010 23:00:00 +0100

Nature 467, 254 (2010). doi:10.1038/467254c N. Engl. J. Med. doi:10.1056/NEJMoa1008433 (2010); Science doi:10.1126/science.1196333 (2010)Genome sequencing has revealed two genes involved in a deadly form of ovarian cancer.Ovarian clear-cell carcinoma is aggressive and difficult to treat. David Huntsman at the British Columbia (Source: Nature)

Genes tied to deadliest ovarian cancers identified

ScienceDaily Headlines — Mon, 13 Sep 2010 08:59:06 +0100

Scientists have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. (Source: ScienceDaily Headlines)

Genetic Mutations Linked With Deadly Ovarian Cancer

Modern Medicine — Sun, 12 Sep 2010 23:00:00 +0100

Ovarian clear cell carcinoma, a particularly aggressive form of ovarian cancer often resistant to standard therapy, appears to be associated with mutations of two specific genes, according to research published online Sept. 8 in Science. (Source: Modern Medicine)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Researchers Identify Genes Tied to Deadliest Ovarian Cancers-9/8/10

Johns Hopkins Medicine News — Fri, 10 Sep 2010 10:06:36 +0100

Gene Mutation May Shift Endometriosis Toward Ovarian Cancer

Medscape Today Headlines — Thu, 09 Sep 2010 16:21:30 +0100

Two new studies identify chromatin-remodeling mutations in ovarian clear-cell carcinomas. Medscape Medical News (Source: Medscape Today Headlines)

Researchers Identify Genes Tied To Deadliest Ovarian Cancers

Health News from Medical News Today — Thu, 09 Sep 2010 09:00:00 +0100

Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. In an article published online in the September 8 issue of Science Express, the researchers report that they found an average of 20 mutated genes per each ovarian clear cell cancer studied... (Source: Health News from Medical News Today)

2 Genes Have Possible Link to Deadly Ovarian Cancer

Cancercompass News: Gynecological Cancer — Thu, 09 Sep 2010 00:00:00 +0100

Scientists say findings may lead to new therapies for ovarian clear cell carcinoma (Source: Cancercompass News: Gynecological Cancer)

Research News: Researchers find genes linked to clear-cell ovarian cancer

OCRF News — Wed, 08 Sep 2010 23:00:00 +0100

Researchers have identified two new genetic mutations that cause a significant number of the hardest-to-treat kinds of ovarian cancer, and say they point to a new "on-off" switch for tumors.Researchers have identified two new genetic mutations that cause a significant number of the hardest-to-treat kinds of ovarian cancer, and say they point to a new "on-off" switch for tumors.They hope their findings may eventually help doctors better tailor cancer treatments and also lead to the development of drugs to treat these forms of cancer. The findings, published by two separate teams of researchers in the journal Science and the New England Journal of Medicine, also suggest a previously unknown mechanism for how cancer begins. The genes affect ovarian clear cell carcinoma, one of the most ag...

MedWorm Sponsor Message: Find the best January Sales in the UK.

2 Genes Have Possible Link to Deadly Ovarian Cancer

The Doctors Lounge - Health News — Wed, 08 Sep 2010 22:00:00 +0100

Scientists say findings may lead to new therapies for ovarian clear cell carcinoma (Source: The Doctors Lounge - Health News)

Researchers identify genes tied to deadliest ovarian cancers

EurekAlert! - Cancer — Wed, 08 Sep 2010 04:00:00 +0100

(Johns Hopkins Medical Institutions) Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. (Source: EurekAlert! - Cancer)

Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy.

Endokrynologia Polska — Wed, 01 Sep 2010 00:00:00 +0100

Conclusions: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland. (Pol J Endocrinol 2010; 61 (5): 427-429). PMID: 21049452 [PubMed - in process] (Source: Endokrynologia Polska)

Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.

Cancer Science — Tue, 31 Aug 2010 23:00:00 +0100

(Source: Cancer Science)

Immunohistochemical evidence for the over-expression of Glutathione peroxidase 3 in clear cell type ovarian adenocarcinoma

Medical Oncology — Sat, 21 Aug 2010 05:50:33 +0100

In this study, the expression of GPX3 mRNA and protein was analyzed for ovarian cancer tissues to test its applicability as a biomarker that can distinguish the four major histologic types of epithelial ovarian cancer. A public microarray dataset containing 99 ovarian cancer and 4 normal ovary samples was downloaded, and GPX3 mRNA expression was analyzed. The expression of GPX3 protein was measured by immunohistochemical staining in 40 epithelial ovarian cancer tissues, 10 for each of the serous, endometrioid, mucinous, and clear cell type. Histoscores were made from the immunohistostaining, and analysis of variance (ANOVA) was performed to quantitate the differences in protein level. Analysis of genomic dataset confirms a GPX3 overexpression in clear cell type ovarian adenocarcinoma...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor: Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene

Annals of Diagnostic Pathology — Mon, 16 Aug 2010 04:00:00 +0100

Abstract: A 34-year-old pregnant woman with bilateral kidney tumors 9.5 and 2.5 cm in maximum diameter is presented. The larger tumor was clear renal cell carcinoma. The smaller contralateral tumor was focally HMB45 positive and had unusual histomorphology, including features resembling clear renal cell carcinoma with features of both t(6;11)- and t(X;17)/ASPL-TFE3 carcinomas. This tumor displayed a complex karyotype. A novel germ line mutation in the VHL gene (c.439A>G/p.I147V) was also identified in this patient. (Source: Annals of Diagnostic Pathology)

Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary

Expert Opinion: Expert Opinion on Therapeutic Targets: Table of Contents — Mon, 09 Aug 2010 06:57:58 +0100

Expert Opinion on Therapeutic Targets, Volume 14, Issue 9, Page 963-971, September 2010. (Source: Expert Opinion: Expert Opinion on Therapeutic Targets: Table of Contents)

Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells.

Gynecologic Oncology — Sun, 08 Aug 2010 23:00:00 +0100

CONCLUSIONS: We have demonstrated for the first time the presence of elevated levels of GPC3 protein associated with cell growth inhibition in CCC cells. Our data suggest that GPC3 has the potential to become a novel therapeutic target for ovarian CCC patients. PMID: 20701957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Radical trachelectomy for clear cell carcinoma of the cervix in a 6-year old: a case report, review, and description of the surgical technique

Journal of Pediatric Surgery — Sat, 31 Jul 2010 23:00:00 +0100

We describe a young patient with clear cell carcinoma of the cervix who, through a multidisciplinary collaboration, was managed by a fertility-sparing alternative surgical approach—a radical trachelectomy. We present the surgical technique and review the current evidence regarding the use of radical trachelectomy as a fertility-sparing procedure in young patients with cervical cancer. (Source: Journal of Pediatric Surgery)

[Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance.]

Journal of Southern Medical University — Wed, 30 Jun 2010 23:00:00 +0100

CONCLUSION: Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC. PMID: 20650808 [PubMed - in process] (Source: Journal of Southern Medical University)

MedWorm Sponsor Message: Find the best January Sales in the UK.

[Review] Targeted therapies for rare gynaecological cancers

The Lancet Oncology — Sun, 27 Jun 2010 23:00:00 +0100

Some gynaecological cancers are uncommon, such as sex cord-stromal tumours, malignant germ-cell tumours, vulvar carcinoma, melanoma of the female genital tract, clear-cell carcinoma of the ovary and endometrium, neuroendocrine tumours of the cervix, and gestational trophoblastic neoplasia. All these cancers have different clinicopathological characteristics, suggesting different molecular biological pathogeneses. Despite aggressive treatment, some cancers recur or respond poorly to therapy. Comprehensive knowledge of the molecular biology of each cancer might help with development of novel treatments that maximise efficacy and minimise toxic effects. Targeted therapy is a new treatment strategy that has been investigated in various tumours in clinical and laboratory settings. Since these c...

CRABP1-reduced expression is associated with poorer prognosis in serous and clear cell ovarian adenocarcinoma

Journal of Cancer Research and Clinical Oncology — Tue, 22 Jun 2010 18:33:44 +0100

Conclusions The present study is the first to demonstrate that the reduced expression of CRABP1 has a potential as a prognostic marker for serous adenocarcinoma which is the most frequent histological ovarian tumor type and also for clear cell carcinoma that often exhibits chemo-resistance. Further study is necessary to clarify how CRABP1 protein expression was altered and how CRABP1 affects ovarian carcinoma cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0930-8Authors Takahito Miyake, Osaka Rosai Hospital Department of Obstetrics and Gynecology 1179-3, Nagasone, Kita-ku Sakai, Osaka 591-8025 JapanYutaka Ueda, Osaka University Graduate School of Medicine Department of Obstetrics and Gynecology 2-2 Yamada-oka Suita, Osaka 565-0871 J...

The Pediatric Renal Clear Cell “Sugar” Tumor: Pseudo-alveolar Structure Mimicking Clear Cell Renal Carcinoma

Urology — Tue, 22 Jun 2010 00:00:00 +0100

We report a renal benign PEST in a 16-year-old boy, which is the first such case to be reported in the pediatric kidney. The tumor was composed of clear and eosinophilic epithelioid cells, growing with nest and pseudoalveolar structure, which can be confused with renal clear cell carcinoma. The tumor cells were positive for melanocytic and negative for epithelial markers. The tumor was enucleated, and the patient was well without recurrence 21 months after surgery. (Source: Urology)

Response to: "Ovarian clear cell carcinoma: High risk of venous thromboembolism"

Gynecologic Oncology — Mon, 14 Jun 2010 23:00:00 +0100

Response to: "Ovarian clear cell carcinoma: High risk of venous thromboembolism" Gynecol Oncol. 2010 Jun 15; Authors: Duska LR, Horowitz N PMID: 20557925 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Epidemiologic characteristics of renal cell carcinoma in Brazil

International Braz J Urol — Sat, 12 Jun 2010 14:33:55 +0100

CONCLUSIONS: RCC in Brazil is more common in white men in their sixth decade of life. Ultrasound is the main diagnostic tool for the diagnosis of clear cell carcinoma and we found that localized disease was predominant. A national registry of RCC is feasible and may provide valuable information. (Source: International Braz J Urol)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Ovarian metastasis after radical nephrectomy for primary renal clear cell carcinoma: a diagnostic challenge

Gynecological Surgery — Fri, 11 Jun 2010 19:48:39 +0100

Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10397-010-0595-yAuthors Mathieu Luyckx, Université Catholique de Louvain Department of Gynecology, Cliniques Universitaires de Mont-Godinne 7430 Yvoir BelgiumJacques Donnez, Université Catholique de Louvain Department of Gynecology, Cliniques Universitaires Saint-Luc Avenue Hippocrate, 10 1200 Brussels BelgiumMonique Delos, Université Catholique de Louvain Department of Gynecology, Cliniques Universitaires de Mont-Godinne 7430 Yvoir BelgiumJoseph Kerger, Université Catholique de Louvain Department of Gynecology, Cliniques Universitaires de Mont-Godinne 7430 Yvoir BelgiumOlivier Donnez, Université Catholique de Louvain Department of Gynecology, Cliniques Universitaires de Mont-Godinne 7430 Yvoir Belgium Journal Gyn...

Genetic heterogeneity and chromatin modifiers in renal clear cell carcinoma

Future Oncology — Tue, 08 Jun 2010 10:25:40 +0100

Future Oncology , June 2010, Vol. 6, No. 6, Pages 897-900. (Source: Future Oncology)

A case of metachronous splenic metastasis from renal cell carcinoma after 14 years

International Journal of Surgery — Sun, 30 May 2010 23:00:00 +0100

We present a case of a patient who developed a metachronous splenic metastasis from renal clear cell carcinoma, for which he has undergone a left nephrectomy 14 years earlier. During his routine follow up a CT scan showed a splenic mass which was considered an isolated metastasis possibly originating from the renal cancer. A splenectomy was performed and histopatological examination of the spleen confirmed the presence of clear cell carcinoma with infiltration of the capsule. Splenic metastases are uncommon and from the reported literature we understand that splenic metastasis from renal cell carcinoma is extremely rare. The optimal treatment seems to be splenectomy with a good long term outcome. With this report the authors would like to discuss the possibility that it could be a case of ...

Evaluation of neuroendocrine markers in renal cell carcinoma

Diagnostic Pathology — Tue, 11 May 2010 23:00:00 +0100

Conclusions: Serotonin, CD56 and NSE but not synaptophysin and chromogranin A are expressed in RCCs. However, the prognostic potential of these markers remains obscure. (Source: Diagnostic Pathology)