MedWorm: Clear Cell Carcinoma

Metastatic renal clear cell carcinoma to the gallbladder

Kidney Cancer Association — Fri, 19 Feb 2010 20:51:46 +0100

Renal cell carcinoma is the most lethal of all urologic malignancies with a high metastatic potential. Approximately 25% of patients present with stage IV disease and up to 40% of patients have disease recurrence after nephrectomy. Computed Tomography is an important imaging modality for initial diagnosis and restaging of this patient population. Although extremely rare, metastatic clear cell renal carcinoma has been reported to metastasize to the gallbladder.02/20/2010 (Source: Kidney Cancer Association)

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Clear cell carcinoma of the lung

General Thoracic and Cardiovascular Surgery — Sat, 13 Feb 2010 06:53:12 +0100

We present here in the case of a patient who underwent resection of clear cell carcinoma of the lung, a rare histological type. A screening test of the 71-yearold woman revealed a 2.0-cm lesion in S4 of the right lung with a diagnosis of bronchioloalveolar carcinoma before resection. Under the guidance of video-assisted thoracoscopy, right middle lobe resection and mediastinal lymph node dissection were performed. The histopathological examination showed clear, slightly acidophilic tumor cells rich in fine granular components proliferating in an alveolar fashion. Immunostaining was diagnostically useful, distinguishing clear cell carcinoma from lung metastasis of renal clear cell carcinoma or clear cell squamous cell carcinoma. Content Type Journal ArticleCategory Case ReportDOI 10...

Thymic clear cell carcinoma

General Thoracic and Cardiovascular Surgery — Sat, 13 Feb 2010 06:53:03 +0100

We report a 42-year-old man with a rare thymic clear cell carcinoma. Marked nodal metastases involved right hilar, mediastinal, and left supraclavicular regions. Complete resection including thymothymectomy, cervicomediastinal nodal dissection, and right upper lobectomy with hilar lymphadenectomy was successful. Postoperative chemoradiation therapy was uneventful. The patient had no recurrence or metastasis until brain metastasis occurred 1 year after surgery. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11748-009-0481-6Authors Tomoyuki Nakano, Jichi Medical University and Saitama Medical Center Department of General Thoracic Surgery and Pulmonary Medicine 1-3311 Yakushiji, Shimotsuke Tochigi 329-0498 JapanShunsuke Endo, Jichi Medical University and Saitama Medical ...

Co-existence of chronic renal failure, renal clear cell carcinoma, and Blau syndrome - Abstract

UroToday — Mon, 08 Feb 2010 23:00:00 +0100

Department of Pediatric Nephrology, Celal Bayar University, Manisa, 45040, Turkey. (Source: UroToday)

Therapy and prognostic features of primary clear cell carcinoma of the liver.

World Journal of Gastroenterology : WJG — Sun, 07 Feb 2010 00:26:17 +0100

CONCLUSION: Postoperative chemotherapy has no obvious effect on survival of patients with PCCCL. Clear cell ratio, capsule formation, preoperative liver function, and vascular invasion were independent risk factors for prognosis. PMID: 20135727 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Primary clear cell carcinoma of hilar bile duct: A case report

Chinese Journal of Digestive Diseases — Wed, 03 Feb 2010 00:00:00 +0100

(Source: Chinese Journal of Digestive Diseases)

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Mucinous but not clear cell histology is associated with inferior survival in patients with advanced stage ovarian carcinoma treated with platinum-paclitaxel chemotherapy

Cancer — Wed, 27 Jan 2010 00:00:00 +0100

Mucinous and clear cell histology have been associated with adverse prognosis in ovarian carcinomas. The authors compared the outcome of these subtypes with that of serous tumors in patients who were treated with combination paclitaxel/platinum at their center.Four hundred twenty patients with histologically confirmed, serous (n = 367), mucinous (n = 24), or clear cell (n = 29) ovarian carcinomas, International Federation of Gynecology and Obstetrics stage III or IV disease, and who were treated with paclitaxel/platinum after cytoreductive surgery were included in this analysis.The median overall survival for each histological subtype was 47.7 months (95% confidence interval [CI], 37.7-57.7 months) for serous, 15.4 months (95% CI, 4.2-26.6 months) for mucinous, and 36.6 months (95% CI, 22....

Co-existence of chronic renal failure, renal clear cell carcinoma, and Blau syndrome

Pediatric Nephrology — Mon, 18 Jan 2010 18:45:57 +0100

We describe here a 14-year-old girl with Blau syndrome with incidentally diagnosed renal carcinoma. The index case presented with growth retardation and recurrent symmetric arthritis. Her clinical symptoms included bilateral cataract due to recurrent uveitis, camptodactyly, and persistent erythematous rash with ichthyosis. Her two sisters and her mother were affected with combinations of these conditions—symmetric polyarthritis, uveitis, and skin involvement—suggesting an autosomal dominant trait. The index case developed a chronic renal insufficiency, and an abdominal computerized tomography scan revealed a 2.5-cm mass in the left kidney. The histopathological examination showed renal clear cell carcinoma, chronic tubulointerstitial nephritis, and giant cell granulomas in both t...

Successful treatment for metastases from renal cell carcinoma with alternation of interferon-alpha subtypes

International Journal of Clinical Oncology — Tue, 12 Jan 2010 06:44:51 +0100

Abstract Here we present a case in which alternation of interferon-alpha (IFN-α) treatments was effective in treating pulmonary metastases and lymph node metastases from renal cell carcinoma (RCC). A 56-year-old man underwent left radical nephrectomy under the diagnosis of left RCC. The histological diagnosis was clear cell carcinoma G2, IFN-α, pT1b. He subsequently underwent two operations for right pulmonary metastasis and right hilar lymph node metastasis. Postoperatively he was treated with intramuscular administration of natural IFN-α (Sumiferon) which prevented definite recurrence for 1 year. However, multiple pulmonary metastases and left hilar lymph node metastasis occurred 11 months after discontinuation of Sumiferon. Therefore, treatment with another ...

Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

Oncogene — Mon, 11 Jan 2010 00:00:00 +0100

Authors: K Yamaguchi, M Mandai, T Oura, N Matsumura, J Hamanishi, T Baba, S Matsui, S K Murphy & I Konishi (Source: Oncogene)

Positive margins after nephron-sparing surgery for renal cell carcinoma: long-term follow-up of patients on active surveillance

BJU International — Fri, 08 Jan 2010 00:00:00 +0100

Study Type [ndash] Therapy (case series)Level of Evidence 4 To analyse our long-term oncological outcomes with active surveillance in patients with positive surgical margins (PSMs) after nephron-sparing surgery (NSS) for renal cell carcinoma (RCC), as this situation is a difficult therapeutic dilemma. We performed open NSS for renal masses with frozen-section analysis of any suspicious zone of the surgical bed, followed by extensive argon-beam coagulation. In patients where the final histopathological examination of the renal mass revealed PSMs, follow-up consisted of computed tomography (CT) every 6 months in the first 2 years and then annually up to 5 years, and thereafter we alternated ultrasonography with CT. From 1995 to 2003 we had 11 cases of microscopic definitive PSMs after NSS fo...

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Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study

Medical Oncology — Thu, 07 Jan 2010 15:59:33 +0100

Abstract The patient was a 30-year-old-pregnant woman (para 1, gradiva 1) without in utero exposure to diethylstilbestrol. A papillary and flat lesion was found by colposcopy in the uterine cervix in the routine examination at 10 pregnancy weeks. Biopsies showed papillary and tubular proliferation of malignant cells with clear glycogen-rich cytoplasm and malignant hobnail cells and were diagnosed as clear cell adenocarcinoma. The patient was treated by radical hysterectomy. The lesion of the cervix (10 × 15 × 5 mm) was clear cell adenocarcinoma with mild invasion into shallow myometrium (pTIb). An immunohistochemical study showed that the tumor cells were positive for pancytokeratins (AE1/3, CAM5.2, KL-1, and polyclonal wide), cytokeratin (CK) 7, ...

Intraperitoneal radioactive phosphorus (32P) and vaginal brachytherapy as adjuvant treatment for uterine papillary serous carcinoma and clear cell carcinoma: The Indiana University experience

Brachytherapy — Tue, 29 Dec 2009 13:46:43 +0100

Conclusions: Adjuvant therapy for UPSC and CCC with intraperitoneal 32P and vaginal brachytherapy after adequate surgical staging and maximal cytoreduction is well tolerated and appears to be effective. Further study is warranted. (Source: Brachytherapy)

Laparoscopic Partial Nephrectomy Using FloSeal for Hemostasis: Technique and Experiences in 102 Patients.

Surgical Innovation — Tue, 22 Dec 2009 00:00:00 +0100

Conclusions. Laparoscopic partial nephrectomy with the use of FloSeal is a feasible and safe method for treatment of small renal masses. The technique is reproducible by surgeons who are used to complex laparoscopic procedures. Patient outcome during follow-up was comparable with data published for open standard procedures. PMID: 20031942 [PubMed - as supplied by publisher] (Source: Surgical Innovation)

Detection of chromosomal aberrations in renal tumors: a comparative study of conventional cytogenetics and virtual karyotyping with single-nucleotide polymorphism microarrays.

Archives of Pathology and Laboratory Medicine — Tue, 01 Dec 2009 00:00:00 +0100

Conclusions.-Our results show that both techniques are able to identify the characteristic chromosomal abnormality for renal tumor subtypes in most cases. Discrepancies can be explained by inherent limitations of each technique, inadequate tumor sampling, and tumor heterogeneity. We conclude that virtual karyotyping is a robust alternative to conventional cytogenetics for the evaluation of chromosomal anomalies in formalin-fixed, paraffin-embedded tissues from renal epithelial neoplasms. PMID: 19961245 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells.

International Journal of Oncology — Thu, 05 Nov 2009 22:16:48 +0100

Authors: Jeong SH, Lee JS, Jeong NY, Kim TH, Yoo KS, Song S, Suh H, Kwon TK, Park BS, Yoo YH Bcl-2 protects cancer cells from the apoptotic effects of various chemotherapeutic agents. Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to bypass chemoresistance in cancer cells. Previously we designed and synthesized the resveratrol analogue HS-1793 displaying stronger antitumor efficacy than resveratrol and further demonstrated the HS-1793 resistance conferred by Bcl-2 in human leukemic U937 cells. We undertook this study to determine if HS-1793 treatment can bypass the anti-apoptotic effects of Bcl-2 in human renal cancer cells, with a specific focus on the involvement of promyelocytic leukemia nuclear bodies (PML-NBs). Experiments were conducted with Bcl-2-ove...

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Severe thrombocytopenia in a patient with metastatic renal cell carcinoma.

Onkologie — Sun, 01 Nov 2009 00:00:00 +0100

CONCLUSIONS: Although very rare, bone marrow carcinosis can occur in patients with mRCC and may present a diagnostic challenge. It is associated with a very poor prognosis. PMID: 19887872 [PubMed - in process] (Source: Onkologie)

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis

International Journal of Clinical Oncology — Sat, 24 Oct 2009 05:57:41 +0100

Abstract We review whether endometriosis-associated ovarian cancer is a specific entity compared with ovarian cancer not associated with endometriosis, with respect to epidemiology, natural history, and clinical diagnosis; we present a review of the English-language literature for ovarian cancer in endometriosis with respect to these three features. A recent prospective study in Japan directly showed that, during a follow-up of up to 17 years of an ovarian endometrioma cohort (n = 6398), 46 incident ovarian cancers were identified, showing that the ovarian cancer risk was significantly elevated in patients with ovarian endometrioma (standardized incidence ratio [SIR], 8.95; 95% confidence interval [CI], 4.12 to 15.3). Advancing age (>40 years) and the size of the endomet...

Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management

International Journal of Clinical Oncology — Sat, 24 Oct 2009 05:57:41 +0100

Abstract Recent molecular and pathological evidence suggests that endometriosis is a monoclonal, neoplastic disease. Moreover, endometriosis serves as a precursor of ovarian cancer (endometriosis-associated ovarian cancer; EAOC), especially of the endometrioid and clear cell subtypes. Although a variety of molecular events, such as p53 alteration, PTEN silencing, K-ras mutations, and HNF-1 activation, have been identified in EAOC, its precise carcinogenic mechanism remains poorly understood. Our recent data indicate that microenvironmental factors, including oxidative stress and inflammation, play an important role in the carcinogenesis and phenotype of EAOC. The management of endometriosis from the standpoint of EAOC is not standardized yet. To this end, clarification of t...

Aberrant expression of p27Kip1-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways

Virchows Archiv — Fri, 23 Oct 2009 18:53:43 +0100

In this study, the expressions of p27Kip1-interacting proteins, i.e., p27Kip1, Skp2, Cks1, cyclin A, cyclin E, and the Ki-67 labeling index (LI), were analyzed in 25 CCAFs (11 benign and 14 borderline) and 15 CCAF-associated CCAs, and compared with the expression status of each protein in the 23 previously studied endometriosis-associated CCAs. Although aberrant expression of all p27Kip1-interacting proteins was more frequent in the CCAF-associated CCAs than in the benign CCAFs, statistical significance was found only for Cks1 overexpression. The frequencies of p27Kip1 downregulation and overexpression of Skp2 and cyclin A were significantly lower in CCAF-associated than in endometriosis-associated CCAs (P < 0.05, respectively). The frequencies of p27Kip1 downregulation and Skp2...

Clinical results and histological changes following preoperative interventional treatment of the aggressive subtype of endometrial cancer

The Chinese-German Journal of Clinical Oncology — Wed, 21 Oct 2009 19:14:47 +0100

Conclusion The preoperative intra-arterial chemotherapy and embolization can improve the operability of resection in patients with aggressive subtype of endometrial carcinoma, reduce the expression of PCNA, adjust malignancy of endometrial carcinoma, and improve prognosis. Content Type Journal ArticleDOI 10.1007/s10330-009-0096-5Authors Yongxiu Qiu, Zhongshan Hospital of Traditional Chinese Medicine Department of Gynecology and Obstetrics Zhongshan 528400 ChinaCunlin Chen, The Southern Medical University Department of Gynecology and Obsterics, Nanfang Hospital Guangzhou 510000 ChinaYili Wei, Zhongshan Hospital of Traditional Chinese Medicine Department of Gynecology and Obstetrics Zhongshan 528400 ChinaJianling Fang, Zhongshan Hospital of Traditional Chinese Medicine D...

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Tumor type and substage predict survival in stage I and II ovarian carcinoma: Insights and implications.

Gynecologic Oncology — Fri, 09 Oct 2009 23:00:00 +0100

CONCLUSIONS: A subset of ovarian carcinoma patients with an excellent outcome can be identified based on tumor type (endometrioid or mucinous) and stage (Ia or Ib). Type is more reproducibly assigned than grade and identifies a larger cohort of women with stage I/II ovarian carcinoma with favorable outcomes (12.2% vs. 6.5%), and therefore is superior to grade in estimating risk of death from ovarian carcinoma. PMID: 19822358 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

HERA Requests Applications for Ovarian Cancer Study

ScanGrants feed — Thu, 08 Oct 2009 23:00:00 +0100

The HERA Women’s Cancer Foundation, a nationally recognized ovarian cancer nonprofit organization, has announced funding for a study focused on type I ovarian cancer; low-grade serous carcinoma, mucinous carcinoma, malignant Brenner tumor and/or clear cell carcinoma. The research will concentrate on the cause, early detection, treatment, and/or understanding of this disease.Scientists and clinicians of non-profit research, medical service and educational institutions located in the U.S are eligible and encouraged to apply. The one-year award for $100,000 will support direct costs of the project, up to 50 percent of salary support, reagents and supplies and other justifiable expenses. Indirect costs are not covered by this award.Letters of intent are due November 1, 2009. Questions a...

De Novo Renal Carcinoma in Renal Transplant Recipients: Effect of Early Treatment

Transplantation Proceedings — Thu, 01 Oct 2009 00:00:00 +0100

Conclusion: The increased risk of tumor in renal transplant recipients leads us to propose extended nephrectomy in the case of suspect lesions in the native kidney. In our patients, 65% of patients had malignant lesions. Good prognosis for these localized tumors justified aggressive therapy even though 35% of transplant recipients were tumor-free. (Source: Transplantation Proceedings)

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo

Cancer Science — Thu, 01 Oct 2009 00:00:00 +0100

We report here that GPC3 was expressed in clear cell carcinoma of the ovary, and not in other carcinomas. To evaluate the phenotype and potential preclinical relevance, we generated an ovarian cancer cell line stably transfected with plasmids encompassing shRNA targeting GPC3. We show that the clear cell carcinoma cell line with silenced GPC3 expression (GPC3 [[minus]]) was more sensitive to paclitaxel than GPC3 (+) cells. In addition, the GPC3 silencing induced sensitization to paclitaxel was associated with the activation of an apoptosis pathway, as shown by flow cytometry. Moreover, we investigated the effect of GPC3 on peritoneal metastases using nude mice. Peritoneal metastases caused by GPC3 ([minus]) were more sensitive to paclitaxel than those caused by GPC3 (+) cells. These result...

Microarray analysis of microRNA expression in renal clear cell carcinoma

European Journal of Surgical Oncology — Mon, 14 Sep 2009 16:13:10 +0100

Conclusion: Our study may help to clarify the molecular mechanisms involved in the pathogenesis of RCCC, and miRNAs potentially serve as a novel diagnostic biomarker of RCCC. (Source: European Journal of Surgical Oncology)

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Paraneoplastic Humorally Mediated Hypercalcemia Induced by Parathyroid Hormone-Related Protein in Gynecologic Malignancies: A Systematic Review.

Onkologie — Sun, 13 Sep 2009 08:36:04 +0100

Authors: Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA Humoral hypercalcemia of malignancy (HHM) is a metabolic phenomenon that is mediated by the paraneoplastic secretion of parathyroid hormone-related peptide (PTHrP). Gynecologic malignant neoplasms complicated by HHM have been reported for organs such as the uterus, cervix, ovary, vulva and the vagina. The purpose of our study was to perform a review of the published cases in the literature and, further, to identify parameters with effect on outcome. Among 34 women with gynecologic neoplasms, 22 suffered from ovarian and 6 from uterine malignancies, while 3 had vulvar and another 3 cervical cancer. Furthermore, clear cell carcinoma was the predominant histology associated with PTH-rP expression. A...

Renal cell carcinoma with bilateral synchronous adrenal gland metastases: a case report

Cases Journal — Tue, 08 Sep 2009 23:00:00 +0100

Conclusion: Patients with bilateral synchronous adrenal metastases should be considered to have disseminated metastatic disease. However, good performance status, the presence of paraneoplastic syndrome and the alleviation of refractory pain are important reasons make an urologist to consider radical nephrectomy in RCC patient with metastases. (Source: Cases Journal)

A Cross-over Response to Sequential Use of Sunitinib after Sorafenib in a Patient with Metastatic Renal Cell Carcinoma

Clinical Oncology — Mon, 07 Sep 2009 17:12:11 +0100

A 62-year-old man underwent a right nephrectomy for clear cell carcinoma of the kidney, but relapsed within 1 year with liver metastases. He was initially treated with sorafenib 400mg orally twice a day; a baseline scan revealed a 32mm index liver metastasis (A). Repeated scanning 6 months later showed progression of the liver metastasis increasing to 54mm (B). Sunitinib, 50mg orally once a day, using a regimen of 4 weeks on and 2 weeks off treatment, was substituted. Three months later, repeat scanning showed a response (C), with a reduction in the liver metastasis to 41mm, which is maintained out to 1 year. (Source: Clinical Oncology)

Novel intronic germline FLCN gene mutation in a patient with multiple ipsilateral renal neoplasms

Human Pathology — Mon, 07 Sep 2009 00:00:00 +0100

We describe here a 64-year-old man with a novel germline mutation in the FLCN gene who presented with 3 phenotypically distinct renal tumors in the same kidney, which were histologically classified as oncocytoma (1.4 cm), oncocytic papillary carcinoma (0.5 cm), and clear cell renal carcinoma (0.8 cm). Genetic analysis of normal kidney tissue revealed a heterozygous germline FLCN mutation (intron 9, IVS9+6 C>T). Additional molecular genetic testing revealed somatic mutations and epigenetic events in genes typically associated with these specific histologic tumor types: oncocytoma harbored a second FLCN mutation (intron 12, IVS12+4 C>T), oncocytic papillary carcinoma harbored promoter methylation of FLCN, and a missense mutation in the MET gene (P246L), whereas clear cell carcinoma harbored ...

Cutaneous metastases in renal cell carcinoma: a case report

Cases Journal — Mon, 24 Aug 2009 23:00:00 +0100

Renal cell carcinoma is the most common form of malignant renal tumour and is extremely lethal. About 25% of the patients develop metastasis at the time of diagnosis, and in many cases during the course of the disease, affecting the lung, lymphatic ganglions, liver, and bone, with skin metastases being quite rare.A 73-year-old patient, who had undergone surgery for adenocarcinoma in the left kidney 10 years previously, visited the dermatological service due to the appearance of recent, rapidly-developing lesion at the back of his neck. It was decided to remove it surgically. The histological study confirmed clear cell carcinoma that was probably of renal origin. A computed tomography scan was performed on the thorax and abdomen, and lesions were observed that were compatible with metastasi...

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Metastatic renal cell carcinoma management

International Braz J Urol — Sat, 22 Aug 2009 11:13:48 +0100

Conclusions: A broader knowledge of clear cell carcinoma molecular biology has permitted the beginning of a new era in mRCC therapy. Benefits of these novel agents in terms of progression-free and overall survival have been observed in patients with mRCC, and, in many cases, have become the standard of care. Sunitinib is now considered the new reference first-line treatment for mRCC. Despite all the progress in recent years, complete responses are still very rare. Currently, many important issues regarding the use of these agents in the management of metastatic renal cancer still need to be properly addressed. (Source: International Braz J Urol)

mTOR Is a Promising Therapeutic Target Both in Cisplatin-Sensitive and Cisplatin-Resistant Clear Cell Carcinoma of the Ovary.

Clinical Cancer Research — Mon, 17 Aug 2009 23:00:00 +0100

CONCLUSION: mTOR is frequently activated in clear cell carcinoma and can be a promising therapeutic target in the management of clear cell carcinoma. Moreover, mTOR inhibition by RAD001 may be efficacious as a second-line treatment of recurrent disease in patients previously treated with cisplatin. (Clin Cancer Res 2009;15(17):5404-13). PMID: 19690197 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

The VHL Tumor Suppressor: Master Regulator of HIF.

Current Pharmaceutical Design — Sat, 15 Aug 2009 02:10:17 +0100

Authors: Haase VH Hypoxia-Inducible Factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix transcription factors that play central roles in cellular adaptation to low oxygen environments. The von-Hippel Lindau tumor suppressor (pVHL) is the substrate recognition component of an E3 ubiquitin ligase and functions as a master regulator of HIF activity by targeting the hydroxylated HIF-alpha subunit for ubiquitylation and rapid proteasomal degradation under normoxic conditions. Mutations in pVHL can be found in familial and sporadic hemangioblastomas, clear cell carcinomas of the kidney, heochromocytomas and inherited forms of erythrocytosis, illustrating the importance of disrupted molecular oxygen sensing in the pathogenesis of these diseases. Tissue-specific gene targe...

Theoretical model of treatment strategies for clear cell carcinoma of the ovary: Focus on perspectives

Cancer Treatment Reviews — Mon, 10 Aug 2009 00:00:00 +0100

Conclusion: The inhibitors that target HNF-1beta and PLK-Emi1 and their downstream signaling molecules would be evaluated. In addition, the therapy currently used in renal CCC should be considered as an alternative for the present treatments or an attractive therapeutic option for ovarian CCC. The challenges accompanying the recent advance are described in this review article. (Source: Cancer Treatment Reviews)

The approach to the patient with paraganglioma.

The Journal of Clinical Endocrinology and Metabolism — Fri, 31 Jul 2009 23:00:00 +0100

Authors: Neumann HP, Eng C The multidisciplinary management of patients with paragangliomas and pheochromocytomas remains challenging. The cornerstone of excellent multidisciplinary management of such patients is genetic classification and management in a tertiary care referral center. Up to one third of all symptomatic presentations of pheochromocytoma or paraganglioma are due to germline mutations in one of six genes defining multiple endocrine neoplasia type 2, von Hippel-Lindau disease, neurofibromatosis type 1, and the paraganglioma syndromes types 1, 3, and 4. This genetic classification forms the basis early diagnosis and follow-up including management of relatives. Easily available clinical information such as tumor location and number, age, gender, and family history must be u...

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Prognostic Factors and Survival of Renal Clear Cell Carcinoma Patients with Bone Metastases.

Pathology Oncology Research — Tue, 28 Jul 2009 23:00:00 +0100

Authors: Szendrői A, Dinya E, Kardos M, Szász AM, Németh Z, Ats K, Kiss J, Antal I, Romics I, Szendrői M In our retrospective study the pathological and clinical factors, influencing the survival of 65 renal clear cell carcinoma patients operated for bone metastasis between 1990 and 2008 were examined. Based on Kaplan-Meier curves age, gender, clinical symptoms, pathological fracture, progression to the soft tissues, localization and size of the metastasis, whether the occurrence of multiplex metastases is multiorganic or only located to the skeletal system and the stage and grade of primary renal cancer did not influence the survival. The survival significantly improved if the bone metastases were solitary, low Fuhrman grade, late onset; and radical surgery was p...

Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer

Cancer Chemotherapy and Pharmacology — Tue, 28 Jul 2009 18:35:43 +0100

Conclusions We first reported that the most relevant genes involved in gemcitabine metabolism are expressed in ovarian carcinoma, and might be associated with more aggressive histotypes. The assessment of the expression levels of RRM2 as marker of clinical outcome deserves further investigation in a larger series of ovarian cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1073-yAuthors Gabriella Ferrandina, Catholic University Department of Oncology Campobasso ItalyValentina Mey, University of Pisa Division of Pharmacology and Chemotherapy, Department of Internal Medicine Pisa ItalySara Nannizzi, University of Pisa Division of Pharmacology and Chemotherapy, Department of Internal Medicine Pisa ItalySimona Ricciardi, Universi...

[Reviews] Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma

Journal of Clinical Pathology — Mon, 27 Jul 2009 23:00:00 +0100

Women with hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome have a high risk for endometrial cancer (EC) and frequently present with a gynaecological cancer as their first or sentinel malignancy. Identification of these patients is important given their personal and family risk for synchronous and metachronous tumours. Modalities to detect ECs for the possibility of HNPCC include microsatellite instability assay, immunohistochemistry for DNA mismatch repair proteins, MLH1 promoter hypermethylation assay and mutational analysis of DNA mismatch repair genes. The revised Bethesda guidelines provide screening criteria for HNPCC in colorectal cancers (CRCs). However, there are currently no such screening recommendations for women with endometrial carcinoma. While age and family...

BRCA2 alteration is important in clear cell carcinoma of the ovary.

Clinical Genetics — Mon, 27 Jul 2009 23:00:00 +0100

Authors: Goodheart M, Rose S, Hattermann-Zogg M, Smith B, De Young B, Buller R BRCA2 has been shown to play a significant role in hereditary ovarian carcinoma. Several cases of clear cell carcinoma (CCC) of the ovary containing BRCA2 mutations have been identified. We hypothesize that sequence variants of the BRCA2 gene are common in CCC of the ovary. Multiple methods were utilized to detect BRCA2 genetic alterations in a cohort of 13 ovarian CCC. These included an LOH analysis for copy number, real-time and methylation-specific polymerase chain reaction (PCR) to probe for BRCA2 promoter methylation, in addition to protein truncation testing (PTT) gel screening for nonsense BRCA2 mutations, and finally direct gene sequencing to either confirm the nonsense mutations or to detect candida...

siRNA targeting Survivin inhibits growth and induces apoptosis in human renal clear cell carcinoma 786-O cells.

Pathology, Research and Practice — Mon, 20 Jul 2009 23:00:00 +0100

Authors: Zhang Y, Chen ZD, Du CJ, Xu G, Luo W We investigated the inhibitory effect of small interfering RNA (siRNA) targeting Survivin gene on cell proliferation and apoptosis in human renal clear cell carcinoma 786-O cells. qRT-PCR, immunocytochemistry, and Western Blot were used to detect Survivin gene expression in 786-O cells. Cell proliferation was determined by BrdU assay and PCNA expression. Cell apoptosis was analyzed through detection of caspase-3 activity, and the effect of Survivin-siRNA on Bcl-2 gene expression was also examined. Forty-eight hours after transfection, Survivin expression was markedly inhibited at the mRNA and protein level. Downregulation of Survivin resulted in a significant inhibition of tumor cell growth. Caspase-3 activity showed that siRNA targeting Su...

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Prevalence of Renal Cell Carcinoma in Patients With Autosomal Dominant Polycystic Kidney Disease and Chronic Renal Failure

Urology — Mon, 20 Jul 2009 23:00:00 +0100

Conclusions: The prevalence of RCC was higher in patients with ADPKD and ESRD, with >1 year on dialysis or renal transplantation undergoing nephrectomy according the protocol. It would be 2 to 3 times more frequent than RCC in patients with ESRD alone. The clinician should maintain a high alert of suspicion for RCC in such patients. (Source: Urology)

Intraventricular metastasis from a clear cell carcinoma of uterine cervix

European Journal of Radiology Extra — Thu, 16 Jul 2009 00:00:00 +0100

We present a 50-year-old woman with history of primary CCA of uterine cervix treated 2 years prior to current presentation noted new onset headache. Brain MRI showed an intraventricular enhancing mass in the left lateral ventricle. Histopathology was consistent with clear cell carcinoma. This is the radiological findings of second case in the literature and demonstrates the potential for spread of primary cervical CCA to the lateral ventricles of brain. (Source: European Journal of Radiology Extra)

Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin

International Journal of Cancer — Mon, 13 Jul 2009 23:00:00 +0100

Clear cell carcinoma (CCC) of the ovary is known to be highly resistant to platinum-based chemotherapy. The purpose of our study was to identify a candidate protein that is associated with chemoresistance of CCC and to investigate the specific mechanism of chemoresistance conferred by the identified protein. Enhanced expression of Annexin A4 (Anx A4) was identified in ovarian CCC cells using 2-D differential gel electrophoresis (2D-DIGE) and mass spectrometry. Anx A4 levels were elevated in CCC cells compared with non-CCC cells as determined by real-time RT-PCR and Western blot analysis. Immunohistochemical analysis of Anx A4 was performed in 126 epithelial ovarian cancer tissue samples and demonstrated significantly elevated levels of Anx A4 protein levels in ovarian CCC tumors compared w...

Clear cell carcinoma of the lower urinary tract in a male patient. Presentation and update on histogenesis and management

Pathology International — Mon, 13 Jul 2009 23:00:00 +0100

(Source: Pathology International)

Seminal Vesicle Metastasis of Renal Cell Carcinoma

Urology — Wed, 08 Jul 2009 00:00:00 +0100

We present an unusual magnetic resonance imaging finding of a 70-year-old man with the seminal vesicle tumor. The patient underwent radical nephrectomy for renal cell carcinoma 4 years ago. Laboratory data, including prostatic-specific antigen, ranged within normal limits. Transrectal needle biopsy disclosed a clear cell carcinoma, which was compatible with the original renal cell cancer. Vesiclectomy was performed. Pathohistologic examination confirmed a metastatic renal cell carcinoma of the seminal vesicle. (Source: Urology)

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Clinical parameters linked with malignancy in endometrial polyps.

Climacteric — Tue, 07 Jul 2009 23:00:00 +0100

Conclusion The prevalence of premalignant and malignant endometrial polyps is very low. Advanced age, menopause, obesity and diabetes increase the risk of endometrial polyp malignancy. PMID: 19591006 [PubMed - as supplied by publisher] (Source: Climacteric)

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Head and Neck Pathology — Mon, 06 Jul 2009 20:04:38 +0100

We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid-Schiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed. ...

Clear cell carcinoma: Review of its histomorphogenesis and classification as a squamous cell lesion

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Wed, 01 Jul 2009 23:00:00 +0100

In current classification schemes, clear cell carcinoma—including both the hyalinized and nonhyalinized variety—is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the typical histomorphology of this neoplasm remains unclear. This review summarizes and illustrates the histologic, ultrastructural, and immunohistochemical evidence for the underlying squamous cell nature of clear cell carcinoma. Squamous cell differentiation is not an uncommon feature of nonneoplastic and neoplastic lesions of the salivary glands. Clear cell carcinoma needs to be added to this list as a unique but specific variety of clear cell squamous carcinoma. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and En...

Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patients

Arquivos Brasileiros de Cardiologia — Thu, 25 Jun 2009 07:26:52 +0100

CONCLUSION: IVC and RA tumor thrombi are more frequent in patients with Wilms' tumor. More postoperative complications are seen in patients with adrenal adenocarcinoma, and the postoperative prognosis is better for patients with Wilms' tumor.FUNDAMENTO: La resección del trombo tumoral en vena cava inferior (VCI) y atrio derecho (AD) aumenta la sobrevida del paciente con cáncer renal/ suprarrenal. OBJETIVO: Evaluar la conducta quirúrgica frente al trombo de la VCI y AD en el tratamiento de los tumores renales y suprarrenales. MÉTODOS: De enero de 1997 a junio de 2007, se evaluaron, retrospectivamente, a 14 pacientes tratados quirúrgicamente para retirada de trombo en VCI y/o AD que transcurre de tumor renal o suprarrenal. De estos, el 64,2% eran del sexo masculino; había el 42,8% de c...

Prognostic Implications of Polymorphisms and Interleukin-2 Therapy for Renal Cell Carcinoma

The Journal of Urology — Sun, 14 Jun 2009 23:00:00 +0100

In this issue of The Journal de Martino et al (page 728) describe a retrospective analysis of a cohort of 54 white patients with metastatic clear cell carcinoma of the kidney with single nucleotide polymorphisms (SNPs) in the carbonic anhydrase 9 (CA9) gene. The authors previously demonstrated a correlation with CA9 protein expression and responsiveness to interleukin (IL)-2 therapy, while others have disagreed based on immunohistochemical staining. Institutions with a strong immunotherapy program have suggested an association of CA9 expression and IL-2 response. This hypothesis is currently being prospectively tested in a Cytokine Working Group phase II study investigating CA9 expression in patients receiving high dose bolus IL-2 therapy. (Source: The Journal of Urology)

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Characterization of Solid Renal Masses using 64-Slice Multidetector CT Scanner

TheScientificWorldJOURNAL: Newly published articles. — Fri, 12 Jun 2009 00:00:00 +0100

The 64-slice multidetector CT scanner with application of enhancement values correction allows diagnosis of clear cell carcinoma. Also, angiomyolipomas could be identified easily with fat inside at the precontrast scan. (Source: TheScientificWorldJOURNAL: Newly published articles.)

Small Renal Masses: Incidental Diagnosis, Clinical Symptoms, and Prognostic Factors

Advances in Urology — Wed, 10 Jun 2009 00:06:29 +0100

Conclusions. Only some SRMs are benign. The great majority of malign SRMs have good prognosis (low stage and grade, no metastasis) with open or laparoscopic surgical treatment (nephron sparing techniques). Active surveillance is an accepted attitude in selected cases. (Source: Advances in Urology)

Four-arm robotic partial nephrectomy for complex renal cell carcinoma

World Journal of Urology — Fri, 05 Jun 2009 09:47:02 +0100

Conclusion Robotic partial nephrectomy is a safe and feasible procedure. RPN is a preferred approach for complex renal tumors when NSS is indicated. For complex and technical challenging renal tumors, robotic assistance may provide patients the benefit of minimally invasive surgery. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00345-009-0427-8Authors Yu Gong, Zhejiang University College of Medicine Department of Urology, Second Affiliated Hospital 310009 Hangzhou Zhejiang ChinaChuanjun Du, Zhejiang University College of Medicine Department of Urology, Second Affiliated Hospital 310009 Hangzhou Zhejiang ChinaDavid Y. Josephson, City of Hope, National Medical Center Department of Urology and Urologic Oncology Duarte, Los Angeles CA 91010 USATimothy ...

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

Cancer Research — Mon, 01 Jun 2009 04:00:00 +0100

Recent insights into the role of the von-Hippel Lindau (VHL) tumor suppressor gene in hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wide analysis of copy-number changes and gene expression profiles in 90 tumors, including both sporadic and VHL disease-associated tumors, in hopes of identifying new therapeutic targets in ccRCC. We identified 14 regions of nonrandom copy-number change, including 7 regions of amplification (1q, 2q, 5q, 7q, 8q, 12p, and 20q) and 7 regions of deletion (1p, 3p, 4q, 6q, 8p, 9p, and 14q). An analysis aimed at identifying the relevant genes revealed VHL as one of three genes in the 3p ...

Clear cell carcinoma of the minor salivary gland: an autopsy case with multiple metastases 29 years after the initial surgery and a review of the literature

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Mon, 01 Jun 2009 04:00:00 +0100

We report an autopsy case of a tumor with widespread metastases 29 years after initial surgery. At the initial presentation, the patient was a 48-year-old man with a small ulcerative tumor in the right hard palate, and the tumor was excised. Twenty-four years after the initial excision, the first recurrence was detected in the lung. Five years later, the patient died of widespread metastases of the disease at the age of 77. Specimens obtained at the initial excision and at autopsy were very similar histologically and immunohistochemically, and both were clear cell carcinoma of the salivary gland. The patient died of the disease after a very long disease-free period, which reinforces the classification of this tumor as a low-grade malignancy. (Source: Oral Surgery, Oral Medicine, Oral Patho...

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Clear cell adenocarcinoma of the urinary bladder: a short review.

Archives of Pathology and Laboratory Medicine — Sun, 31 May 2009 23:00:00 +0100

Authors: Adeniran AJ, Tamboli P In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential di...

Minimizing tumor burden by extensive cytoreductive surgery decreases postoperative venous thromboembolism in ovarian clear cell carcinoma

Archives of Gynecology and Obstetrics — Thu, 21 May 2009 06:15:54 +0100

Conclusion Minimizing residual tumor by extensive cytoreductive surgery with peri-operative thromboprophylaxis may decrease the incidence of a postoperative VTE in patients with OCCC. Larger, prospective studies are needed to confirm these preliminary findings. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1120-2Authors Myong Cheol Lim, National Cancer Center Center for Uterine Cancer, Research Institute and Hospital 111 Jungbalsan-ro, Ilsandong-gu Goyang-si Gyeonggi-do 410-769 KoreaHee Seok Lee, National cancer Center Center for Lung Cancer, Research Institute and Hospital Goyang Gyeonggi KoreaSokbom Kang, National Cancer Center Center for Uterine Cancer, Research Institute and Hospital 111 Jungbalsan-ro, Ilsandong-gu Goyang-si Gyeonggi-d...

Prognostic significance of histological grade in clear-cell carcinoma of the ovary: a retrospective study of Korean Gynecologic Oncology Group

Annals of Oncology — Thu, 21 May 2009 04:00:00 +0100

Conclusions: The stage, residual tumor, and universal grade were significant prognostic factors in patients with CCC of the ovary. The universal grading system is applicable in determining prognosis of CCC of the ovary. Further clinical trials for optimal chemotherapy are in need. (Source: Annals of Oncology)

The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinoma

International Urology and Nephrology — Sat, 16 May 2009 05:59:56 +0100

Conclusions The MC count was not associated with tumor status such as tumor stage, size, grade, and other clinicopathologic parameters, however, MCs may be related to tumor angiogenesis and acceleration of tumor growth in RCC and therefore need further evaluation in RCC. Content Type Journal ArticleCategory Urology - Original PaperDOI 10.1007/s11255-009-9577-2Authors Mohammad Ghassem Mohseni, University of Tehran Department of Urology Sina Hospital, Hassan Abad Square, Hafez Street 113674911 Tehran IranAbdolreza Mohammadi, University of Tehran Department of Urology Sina Hospital, Hassan Abad Square, Hafez Street 113674911 Tehran IranAmir Said Heshmat, University of Tehran Department of Urology Sina Hospital, Hassan Abad Square, Hafez Street 113674911 Tehran IranFarid ...

Initial Experience with the Radiotracer Anti-1-amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid (Anti-[18F]FACBC) with PET in Renal Carcinoma

Molecular Imaging and Biology — Sat, 16 May 2009 05:56:41 +0100

Conclusions In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0220-5Authors David M. Schuster, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAJonathon A. Nye, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAPeter T. Nieh, Emory University Department of Urology Atlanta GA USAJohn R. Votaw, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USARaghuveer K. Halkar, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAMuta M. Issa, Emory University ...

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Clear cell carcinoma originating from ectopic thymus

General Thoracic and Cardiovascular Surgery — Thu, 14 May 2009 06:55:15 +0100

Abstract Cancer of the mediastinum is known to be a relatively rare disease, and clear cell carcinoma in the mediastinum is especially rare. Ectopic thymus is not uncommon, but clear cell carcinoma originating from ectopic thymus has never been reported. We report a case of clear cell carcinoma originating from ectopic thymus in which there was a good response to steroid-supplemented chemoradiotherapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11748-008-0354-4Authors Masaya Okuda, Kagawa University Department of General Thoracic, Breast, and Endocrinological Surgery, Faculty of Medicine 1750-1 Ikenobe, Miki-cho, Kita-gun Kagawa 761-0793 JapanCheng-long Huang, Kagawa University Department of General Thoracic, Breast, and Endocrinological Surgery, Facult...

[Treatment of metastatic renal cancer: current validity of immunotherapy]

Actas Urologicas Espanolas — Thu, 30 Apr 2009 23:00:00 +0100

CONCLUSIONS: Currently, after the advent of new drugs, use of conventional immunotherapy may be indicated for specific patients with a good general condition undergoing previous nephrectomy for a clear cell carcinoma at least 12 months before occurrence of metastasis in a single organ, preferably the lung, and with normal levels of hemoglobin, calcium, and lactate dehydrogenase, looking for that small percentage of stable and sustained responses. PMID: 19658313 [PubMed - in process] (Source: Actas Urologicas Espanolas)

Targeted Therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinoma

Nature Clinical Practice Oncology — Fri, 24 Apr 2009 08:40:05 +0100

Targeted Therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinoma Nature Reviews Clinical Oncology 6, 253 (2009). doi:10.1038/nrclinonc.2009.45 Author: Ronald M. Bukowski Rini and colleagues provide additional data on bevacizumab and interferon-α in clear-cell carcinoma of the kidney; a comparison of these results with the findings from contemporary trials suggests that bevacizumab and interferon-α is another clinically useful treatment option for patients with metastatic renal-cell carcinoma. (Source: Nature Clinical Practice Oncology)

Primary lung clear cell carcinoma: one case report

The Chinese-German Journal of Clinical Oncology — Tue, 21 Apr 2009 10:07:03 +0100

Content Type Journal ArticleDOI 10.1007/s10330-009-0029-3Authors Li Duan, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaTiecheng Pan, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaXiang Wei, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaMin Hu, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 16...

Aberrant adrenocortical tissue in hernia sac occurring in an adult: case report and review of the literature

Hernia — Wed, 15 Apr 2009 08:01:20 +0100

We report a rare case of aberrant adrenocortical tissue in hernial sac. We review the literature and highlight the clinical implications of this incidental finding. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10029-009-0501-6Authors D. El Demellawy, Northern Ontario School of Medicine Department of Pathology and Laboratory Medicine, William Osler Health Center, Brampton Civic Hospital 2100 Bovaird East Drive Brampton ON CanadaA. Nasr, University of Toronto Department of Pediatric Surgery, Sick Kids Hospital Toronto ON CanadaA. Samkari, McMaster University Department of Pathology and Molecular Medicine, Hamilton Health Sciences Center Hamilton ON CanadaP. Pastolero, University of Toronto Faculty of Science Toronto ON CanadaS. Alowami, McMaster University Department of...

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Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms

Human Pathology — Tue, 14 Apr 2009 23:00:00 +0100

In conclusion, hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms because (1) clear cell carcinoma and serous borderline tumor do not coexist and (2) hobnail-like cells in clear cell carcinoma and serous borderline tumor are immunophenotypically distinct. Recognition of our conclusion may protect a patient with “conspicuous hobnail-like cells in serous borderline tumor” from an erroneous overdiagnosis of “concomitant clear cell carcinoma admixed with serous borderline tumor.” (Source: Human Pathology)

Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma.

The American Journal of Pathology — Mon, 06 Apr 2009 04:00:00 +0100

In this study, we analyzed 97 ovarian CCCs for sequence mutations in KRAS, BRAF, PIK3CA, TP53, PTEN, and CTNNB1 as these mutations frequently occur in other major types of ovarian carcinomas. The samples included 18 CCCs for which affinity-purified tumor cells from fresh specimens were available, 69 microdissected tumors from paraffin tissues, and 10 tumor cell lines. Sequence mutations of PIK3CA, TP53, KRAS, PTEN, CTNNB1, and BRAF occurred in 33%, 15%, 7%, 5%, 3%, and 1% of CCC cases, respectively. Sequence analysis of PIK3CA in 28 affinity-purified CCCs and CCC cell lines showed a mutation frequency of 46%. Samples with PIK3CA mutations showed intense phosphorylated AKT immunoreactivity. These findings demonstrate that ovarian CCCs have a high frequency of activating PIK3CA mutations. We...

Heavily Pigmented Renal Cell Carcinoma: A Case Report, With Review of the Literature and Differential Diagnosis

International Journal of Surgical Pathology — Wed, 18 Mar 2009 04:00:00 +0100

Clear cell carcinoma is the most common histotype among renal cell tumors. The prominent vascular network of sinusoidal vessels lined by delicate endothelial cells may often lead to hemorrhagic areas with secondary deposition of chunky birefringent hemosiderin granules. The finding of pigmentation other than iron, and in particular melanin deposits, in renal tumors is a rare occurrence that should lead to differential diagnosis with other primary and metastatic tumors of the kidney. (Source: International Journal of Surgical Pathology)

Multilocular Cystic Nephroma and Multicystic Clear Cell Carcinoma: Two Faces of the Roman God Janus?

International Journal of Surgical Pathology — Wed, 18 Mar 2009 04:00:00 +0100

(Source: International Journal of Surgical Pathology)

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas.

Clinical Cancer Research — Tue, 17 Mar 2009 04:00:00 +0100

CONCLUSION: Our data provide strong circumstantial evidence that PPM1D is a potential therapeutic target for a subgroup of ovarian clear cell carcinomas. PMID: 19293255 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Glycogen-rich clear cell carcinoma of the breast: a case report

Journal of Medical Ultrasonics — Thu, 12 Mar 2009 13:44:50 +0100

Abstract Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare malignant breast tumor. We recently encountered a case of GRCC and report our imaging findings here. The patient was a 49-year-old woman with a mass in her right breast. Mammographic study showed no definite mass shadow because the breast was dense. No calcifications were identified. Ultrasonography disclosed a hypoechoic mass that had a diameter of 1.3 cm, partially irregular borders, heterogeneous internal echoes, and posterior acoustic enhancement, suggesting an invasive carcinoma. Histologic study of core needle biopsy specimens showed a solid proliferation of large clear carcinoma cells, suggestive of a ductal carcinoma. The carcinoma cells possessed clear cytoplasm larger than that typical of ...

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.

Gynecologic Oncology — Mon, 09 Mar 2009 04:00:00 +0100

CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

IGF2BP3 (IMP3) Expression Is a Marker of Unfavorable Prognosis in Ovarian Carcinoma of Clear Cell Subtype

Medscape Pathology Headlines — Fri, 06 Mar 2009 22:35:02 +0100

In this study, IGF2BP3 is evaluated as a potential biomarker for cancer prediction and treatment decisions. Modern Pathology (Source: Medscape Pathology Headlines)

Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients

Molecular Cancer — Thu, 05 Mar 2009 05:00:00 +0100

Conclusion: These data indicate that tuberin deficiency in angiomyolipoma enhances mTOR activation by phosphorylation of S6K and downregulation of protein and mRNA expression of OGG1 resulted in accumulation of oxidized DNA in patients with TSC. These data suggest that tuberin and OGG1 are important proteins in the pathogenesis of angiomyolipoma in TSC patients. (Source: Molecular Cancer)

Glypican-3: A Novel Diagnostic Marker for Hepatocellular Carcinoma and More

Advances in Anatomic Pathology — Sun, 01 Mar 2009 05:00:00 +0100

This article reviews the current information on the application of GPC3 immunostaining in surgical pathology and cytology. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology)

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Epithelial ovarian cancer: Focus on genetics and animal models.

Cell Cycle — Thu, 19 Feb 2009 06:57:45 +0100

Authors: Shan W, Liu J Despite rapid advances in understanding ovarian cancer etiology, epithelial ovarian cancer remains the most lethal form of gynecologic cancers in the United States. The four morphologically-defined epithelial ovarian cancer subtypes-serous, endometrioid, mucinous, and clear cell carcinomas-are generally believed to originate from ovarian epithelial cells. Although it remains unclear how this single cell layer gives rise to morphologically distinct cancers, it has been suggested that early genetic events may direct the differentiation of ovarian epithelial cells. A number of genetic alterations are frequently encountered during ovarian tumorigenesis, including oncogenic activities of KRAS, BRAF and AKT, and silencing mutations of TP53, RB and PTEN. However, knowle...

Angiosarcoma of the Kidney with Minute Clear Cell Carcinomas: A Case Report - Abstract

UroToday — Thu, 05 Feb 2009 23:00:00 +0100

Department of Pathology, The Jikei University School of Medicine, The Jikei Daisan Hospital, 4-11-1, Izumihoncho, Komaeshi, Tokyo 201-8601, Japan.... (Source: UroToday)

Prognostic significance of histological grade in clear-cell carcinoma of the ovary: a retrospective study of Korean Gynecologic Oncology Group.

Ann Oncol — Wed, 04 Feb 2009 05:00:00 +0100

CONCLUSIONS: The stage, residual tumor, and universal grade were significant prognostic factors in patients with CCC of the ovary. The universal grading system is applicable in determining prognosis of CCC of the ovary. Further clinical trials for optimal chemotherapy are in need. PMID: 19193704 [PubMed - as supplied by publisher] (Source: Ann Oncol)

[Novel therapeutic targets in metastatic renal cell carcinoma. Results of the treatment with single-agent bevacizumab in a single institution]

Actas Urologicas Espanolas — Sun, 01 Feb 2009 00:00:00 +0100

CONCLUSIONS: Bevacizumab offers, as single agent, modest activity in the metastatic renal cell carcinoma. The recently labeled use in combination with interferon as well as the newer targeted agents will improve the results of the treatment of this disease in the next future. PMID: 19418836 [PubMed - indexed for MEDLINE] (Source: Actas Urologicas Espanolas)

Small Renal Masses: Incidental Diagnosis, Clinical Symptoms, and Prognostic Factors

Advances in Urology — Thu, 22 Jan 2009 10:35:27 +0100

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Angiosarcoma of the kidney with minute clear cell carcinomas: A case report.

Pathology, Research and Practice — Tue, 13 Jan 2009 05:00:00 +0100

Authors: Fukunaga M A case of renal angiosarcoma with minute clear cell carcinomas in a 61-year-old male is described. The tumor was clinically considered a renal cell carcinoma. The lesion, removed by nephrectomy, was an unencapsulated hemorrhagic mass measuring 8.0cm in diameter. The tumor was histologically characterized by anastomosing vascular channels lined by cytologically atypical endothelial cells. The tumor cells reacted positively with CD31, factor-VIII related antigen, and CD34. A few minute clear cell carcinomas measuring less than 1mm were observed in the periphery of the angiosarcoma. There was no transition between angiosarcoma and renal cell carcinoma. The patient died of a widespread disease 13 months after surgery. This tumor is considered a primary renal angiosarcom...

Relation Between Laminin-5 [gamma]2 Chain and Cell Surface Metalloproteinase MT1-MMP in Clear Cell Carcinoma of the Ovary.

International Journal of Gynecological Pathology — Wed, 24 Dec 2008 10:02:19 +0100

Page: 49DOI: 10.1097/PGP.0b013e3181808021Authors: Kato, Noriko M.D.; Motoyama, Teiichi M.D. (Source: International Journal of Gynecological Pathology)

Distribution of Renal Tumor Growth Rates Determined by Using Serial Volumetric CT Measurements.

Radiology — Sat, 20 Dec 2008 13:58:42 +0100

Conclusion: Growth rates in renal tumors of different sizes, subtypes, and grades represent a wide range and overlap substantially. Small renal tumors appear to be similar to larger ones in nature. (c) RSNA, 2009. PMID: 19092093 [PubMed - in process] (Source: Radiology)

Primary Small Cell Neuroendocrine Carcinoma of the Kidney: Morphological, Immunohistochemical, Ultrastructural, and Cytogenetic Study of a Case and Review of the Literature

Endocrine Pathology — Fri, 19 Dec 2008 08:33:32 +0100

Abstract Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In addition, we have reviewed the literature and compared the published clinicopathological data with our morphological and genetic results. The tumor arose within the kidney parenchyma and showed the typical histological features of a pure small cell PDNEC. Fluorescence in situ hybridization study demonstrated a complex chromosomal assessment indicative of a high degree of chromosome instability with gain of multiple chromosomes, loss of p53, and amplifica...

Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis

APMIS — Fri, 05 Dec 2008 05:00:00 +0100

Kauppila S, Altinörs M, Väre P, Liakka A, Knuuti E, Nissi R. Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis. Case report. APMIS 2008;116:842[ndash]5. Endometriosis, a relatively common disease generally affecting women in the reproductive age group, is mostly found in the pelvic organs. Although endometriosis is a benign disease, some malignant tumors have been reported to develop in endometriotic lesions, most commonly in the ovary. The relationship between endometriosis and malignancy is not well known, but the majority of endometriosis-associated ovarian malignancies are usually endometrioid adenocarcinomas and clear cell carcinomas. The sex cord-like variant of endometrioid adenocarcinoma is a rare tumor that histologically closely resembles t...

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Atypical choriocarcinoma

Chinese Journal of Cancer Research — Mon, 01 Dec 2008 06:55:09 +0100

Abstract Atypical choriocarcinoma is a rare type of gestational trophoblastic disease and only 3 cases were diagnosed among a total of 696 patients with choriocarcinoma admitted to our hospital from 1949 through 1985. Atypical choriocarcinoma is different from the regular choriocarcinoma in both histopathology and clinical manifestations. Morphologically, the tumor cells are predominantly cyto-trophoblast and clinically, the hCG titer is very low which is undetectable by routine biological or immunologic assays. Therefore, it is not infrequently misdiagnosed as sarcoma, squamous cell carcinoma or clear cell carcinoma of the uterus. A comprehensive review of the past history and clinical manifestations is most essential to obtain a correct diagnosis. Content Type Journal ...

Synchronous primary tumors of the kidney and the ovaries: Imaging findings

Journal of Radiology Case Reports — Sat, 29 Nov 2008 16:35:12 +0100

We present a case of an elderly woman, diagnosed with bilateral ovarian clear cell carcinomas and a simultaneous clear cell carcinoma of the right kidney, evaluated by multidetector CT and MR imaging. (Source: Journal of Radiology Case Reports)

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

Virchows Archiv — Thu, 20 Nov 2008 08:10:58 +0100

We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distin...

11C-Acetate PET imaging for renal cell carcinoma

European Journal of Nuclear Medicine and Molecular Imaging — Wed, 19 Nov 2008 07:57:37 +0100

Conclusion AC demonstrates marked uptake in renal cell carcinoma. These preliminary data show that AC is a possible PET tracer for detection of renal cancer. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00259-008-0981-0Authors Nobuyuki Oyama, University of Fukui Department of Urology 23-3 Matsuoka-Shimoaizuki, Eiheiji Fukui 910-1193 JapanHidehiko Okazawa, University of Fukui Biomedical Imaging Research Center Fukui JapanNaoya Kusukawa, University of Fukui Department of Urology 23-3 Matsuoka-Shimoaizuki, Eiheiji Fukui 910-1193 JapanTaisei Kaneda, University of Fukui Department of Urology 23-3 Matsuoka-Shimoaizuki, Eiheiji Fukui 910-1193 JapanYoshiji Miwa, University of Fukui Department of Urology 23-3 Matsuoka-Shimoaizuki, Eiheiji Fukui 910-1193 ...

Hyalinizing clear cell carcinoma

Cancer — Wed, 05 Nov 2008 05:00:00 +0100

(HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor.The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature.To the best of the authors'...

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Expression of angiotensin II receptor type 1 and 2 in ovarian epithelial tumors

Basic and Applied Pathology — Tue, 04 Nov 2008 05:00:00 +0100

Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology)

Loss of DNA Mismatch Repair Protein hMSH6 in Ovarian Cancer is Histotype-Specific.

International Journal of Clinical and Experimental Pathology — Sun, 02 Nov 2008 19:20:04 +0100

Authors: Zhai QJ, Rosen DG, Lu K, Liu J Microsatellite instability (MSI) due to defects in DNA mismatch repair genes may be involved in the development of a subset of human ovarian carcinomas. The role of one such gene, hMSH6, in ovarian cancer is not well documented. We investigated the expression of hMSH6 protein in different histotypes of ovarian carcinoma and the associations between loss of hMSH6 protein and tumor grade, disease stage, familial history of cancer and patient survival. We stained an ovarian carcinoma tissue microarray consisting of formalin-fixed, paraffin-embedded tissue samples from 322 patients with an anti-hMSH6 antibody and scored the results semiquantitatively as negative or positive. Twelve cases were excluded owing to loss of cores during staining. Absence o...

Claudin-1 Protein Expression is a Prognostic Marker of Patient Survival in Renal Cell Carcinomas.

Clinical Cancer Research — Sat, 01 Nov 2008 04:00:00 +0100

CONCLUSIONS: Claudin-1 is expressed in the majority of papillary renal cell carcinomas, suggesting a diagnostic value of this marker. Its expression is an independent prognosticator of shortened disease-specific patient survival in clinically relevant subgroups of clear cell renal cell carcinoma. Further functional studies are needed to clarify the different biological roles of claudin-1 expression in these histologic subtypes of renal cell carcinoma. PMID: 18981000 [PubMed - in process] (Source: Clinical Cancer Research)

Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: High level expression in clear cell carcinoma.

Gynecologic Oncology — Wed, 29 Oct 2008 04:00:00 +0100

CONCLUSIONS: The high level expression of MMP-14 together with in vitro functional analyses suggest that MMP-14 may contribute to both the proliferative capacity and the enhanced parenchymal metastasis of ovarian clear cell carcinoma. PMID: 18976802 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Estrogen and progestin regulate metastasis through the PI3K/AKT pathway in human ovarian cancer.

International Journal of Oncology — Sun, 26 Oct 2008 12:12:05 +0100

Authors: Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y Estrogen and progestin are involved in ovarian carcinogenesis. Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. Therefore, it is critical to understand the signaling pathways that regulate hormone-induced cell migration and invasion in ovarian cancer. We investigated nm23-H1, AKT and pAKT expression by using immunohistochemical staining in ovarian clear cell adenocarcinoma, ovarian benign, borderline and malignant serous tumors and analyzed their relationship with prognostic factors. Using ES-2 and SKOV-3 ovarian cancer cell lines, we studied the modulation of estrogen and progestin on cell migration and invasion as well as their effect on AK...

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Cytological features of chromophobe renal cell carcinoma, classic type. A report of nine cases

Cytopathology — Fri, 24 Oct 2008 04:00:00 +0100

Conclusions: There is increasing evidence that a cytological diagnosis of ChRCC is possible. In our experience the histopathological features of ChRCC were well reflected in cytological samples, allowing specific recognition. In our cases the main differential diagnosis considered was clear cell carcinoma. Cytology can be especially helpful in the evaluation of intraoperative samples. (Source: Cytopathology)

Oxyphilic clear cell carcinoma ovary

Journal of Postgraduate Medicine — Wed, 22 Oct 2008 08:17:03 +0100

Choudhury M, Pujani M, Singh S K, Biswas RJournal of Postgraduate Medicine 2008 54(4):326-327 (Source: Journal of Postgraduate Medicine)

MicroRNA Profiles Help Distinguish Among Renal Cell Carcinomas and Hold Prognostic Potential

Medscape Medical News Headlines — Mon, 20 Oct 2008 15:26:00 +0100

The expression profiles of 25 micro (mi)RNAs of chromophobe renal cell carcinoma (CHRCC), papillary renal cell carcinoma (PRCC), and clear cell carcinoma (CCRCC) were analyzed. A total of 7 miRNAs in CCRCC were upregulated, as were 9 in PRCC, and 20 in CHRCC. Medscape Medical News (Source: Medscape Medical News Headlines)

Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c

The Journal of Pathology — Fri, 17 Oct 2008 04:00:00 +0100

We investigated expression profiles of microRNA (miRNA) in renal cell carcinoma [clear cell carcinomas (CCC) and chromophobe renal cell carcinomas (ChCC)] and in normal kidneys by using a miRNA microarray platform which covers a total of 470 human miRNAs (Sanger miRBase release 9.1). Unsupervised hierarchical cluster analysis revealed that CCC and ChCC were separable and that no subgroups were identified in CCCs. We found that 43 miRNAs were differentially expressed between CCC and normal kidney, of which 37 were significantly down-regulated in CCC and the other 6 were up-regulated. We also found that 57 miRNAs were differentially expressed between ChCC and normal kidney, of which 51 were significantly down-regulated in ChCC and the other 6 were up-regulated. Together, these observations i...

Wilms' tumor gene 1 (WT1) in endometrial carcinoma.

Gynecologic Oncology — Wed, 15 Oct 2008 04:00:00 +0100

CONCLUSION: Although WT1 is expressed in a majority of endometrial carcinomas, a heterogeneous staining pattern is observed. This information is important for WT1-directed immunotherapy. PMID: 18929401 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report and review of the literature

Fertility and Sterility — Wed, 01 Oct 2008 04:00:00 +0100

Conclusion(s): The malignant transformation of abdominal wall endometrioma has not been clearly elucidated, owing to its rarity. However, the eventuality should always be considered, and the prognosis improved through wide surgical excision. (Source: Fertility and Sterility)

Primary clear cell carcinoma of the nasopharynx.

Otolaryngology - Head and Neck Surgery — Wed, 01 Oct 2008 04:00:00 +0100

Authors: Cheng LH, Lin YS, Lee JC PMID: 18922351 [PubMed - in process] (Source: Otolaryngology - Head and Neck Surgery)

Oral cavity metastasis of renal cell carcinoma: a case report

Journal of Medical Case Reports — Mon, 29 Sep 2008 04:00:00 +0100

Conclusion: Metastatic renal cell carcinoma is part of the differential diagnosis for patients presenting with a new head or neck lesion in the setting of a history of kidney cancer. The physician needs to be prepared for the increased risk of bleeding and understand the importance of immunohistochemical staining to differentiate between metastatic renal cell carcinoma and malignancies of salivary origin. Unfortunately, the prognosis is invariably poor in these patients. (Source: Journal of Medical Case Reports)

RASSF1A protein expression and correlation with clinicopathological parameters in renal cell carcinoma

BioMed Central — Fri, 26 Sep 2008 04:00:00 +0100

Conclusions: While most tumors demonstrate a loss of RASSF1A protein, a subset of tumors was identified to exhibit substantial RASSF1A protein expression and show increased tumor progression. Thus RCC tumorigenesis without depletion of RASSF1A may be associated with an adverse clinical outcome. (Source: BioMed Central)

Association between ovarian endometriosis and malignancy in the peri-menopausal period: report of two cases and review of the literature

Gynecological Surgery — Thu, 25 Sep 2008 07:21:41 +0100

We report two cases of peri-menopausal women in which endometriosis was associated to ovarian malignancy. The first case was a 49-year-old woman who underwent laparoscopic oophorectomy for an ovarian endometrioid cyst. Definitive histology showed ovarian endometrioid cyst with endometrioid and clear cell carcinoma. Subsequently, surgical restaging was performed. The other case was a 49-year-old woman who underwent hysterectomy and bilateral oophorectomy for an ovarian mass suggestive of endometriosis and uterine myomas. At frozen section examination, ovarian adenocarcinoma was found and staging procedure was performed. Definitive histology showed carcinosarcoma of the ovary with areas of endometriod adenocarcinoma. Given the non-infrequent association between ovarian endometriosis a...

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Intraoperative Assessment of Clear Cell Carcinoma of the Ovary.

International Journal of Gynecological Pathology — Sat, 20 Sep 2008 09:56:39 +0100

Page: 475DOI: 10.1097/PGP.0b013e31816b5cffAuthors: Stewart, Colin J. R. F.R.C.P.A.; Brennan, Barbara A. F.R.C.P.A.; Hammond, Ian G. F.R.A.N.Z.C.O.G.; Leung, Yee C. F.R.A.N.Z.C.O.G.; McCartney, Anthony J. F.R.A.N.Z.C.O.G.; Ruba, Sukeerat F.R.C.P.A. (Source: International Journal of Gynecological Pathology)

Advanced-stage renal cell carcinoma treated by radical nephrectomy and adjacent organ or structure resection

BJU International — Mon, 08 Sep 2008 04:00:00 +0100

To examine the effect of radical nephrectomy (RN) with adjacent organ and structure resection on survival, as invasion of adjacent organs in patients with renal cell carcinoma (RCC) is rare. After institutional review board approval, we reviewed our database and statistically analysed of patients with pathological stage T3 or T4 RCC who had RN and resection of a contiguous organ or structure. We identified 38 patients of 2464 (1.5%) who had RN with adjacent organ or structure resection. The median (interquartile range) size of the mass was 11 (8[ndash]14) cm, and the follow-up 13 (5[ndash]33) months. Most patients (68%) were pT4 stage and had conventional clear cell carcinoma (95%). Fourteen patients (37%) had positive surgical margins. The liver (10) was the most commonly resected adjacen...

Re: Jehonathan H. Pinthus, Nir Kleinmann, Britton Tisdale et al. Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney. Eur Urol 2008;54:866-74.

European Urology — Sun, 07 Sep 2008 04:00:00 +0100

Authors: Kapoor S PMID: 18789573 [PubMed - as supplied by publisher] (Source: European Urology)

The role of radiotherapy in the management of resected uterine papillary serous and clear cell carcinoma.

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Thu, 04 Sep 2008 04:00:00 +0100

CONCLUSIONS: Hysterectomy with adjuvant radiotherapy significantly improves disease-free survival within 2 years post-hysterectomy and significantly reduces loco-regional failures over hysterectomy alone. PMID: 18774213 [PubMed - as supplied by publisher] (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Unusual clear cell tumours of the jaws clinical and histopathological considerations: a case report

BioMed Central — Mon, 01 Sep 2008 04:00:00 +0100

Conclusion: The authors report a case of a clear cell neoplasm involving the jaw in which histopathological exam presented an indeterminate histology. The histological characteristics of this tumor make it unique in the international literature. (Source: BioMed Central)

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Unusual clear cell tumours of the jaws - clinical and histopathological considerations: a case report

Journal of Medical Case Reports — Mon, 01 Sep 2008 04:00:00 +0100

Clear Cell Adenocarcinoma of Urinary Bladder and Urethra: Another Urinary Tract Lesion Immunoreactive for P504S.

Archives of Pathology and Laboratory Medicine — Mon, 01 Sep 2008 04:00:00 +0100

Conclusion.-The immunohistochemical profile of clear cell carcinomas shares some similarity to conventional urothelial carcinoma; however, it deviates from those tumors in being positive for P504S and negative for p63. This staining profile may suggest a nonurothelial origin for these tumors, may serve as a useful tool in the differential diagnosis of this tumor, and may reflect its etiology. Because similar expression of P504S is also seen in nephrogenic adenomas, this marker should not be used to differentiate nephrogenic adenomas from clear cell adenocarcinomas. PMID: 18788852 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

A subcutaneous mandibulotomy approach for a salivary clear cell carcinoma of the retromolar trigone

Irish Journal of Medical Science — Tue, 12 Aug 2008 07:34:12 +0100

Conclusion This is the first occasion a subcutaneous mandibulotomy approach for an oral tumour has been described in Great Britain and Ireland, the second reported case of clear cell carcinoma originating in the retromolar trigone region and only the fourth case of associated lymph nodal metastases. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11845-008-0201-8Authors B. G. Fennessy, St James Hospital Department of Otorhinolaryngology Head and Neck Surgery Dublin 8 IrelandP. Sheahan, St James Hospital Department of Otorhinolaryngology Head and Neck Surgery Dublin 8 IrelandM. Toner, Trinity College School of Dental Science Dublin 2 IrelandC. Timon, St James Hospital Department of Otorhinolaryngology Head and Neck Surgery Dublin 8 Ireland Journal I...

Prognostic factors in endometrial carcinoma

Journal of Obstetrics and Gynaecology Research — Thu, 24 Jul 2008 04:00:00 +0100

Endometrial carcinoma is the most common malignancy of the female genital tract in industrialized countries, and occurs predominantly after the menopause. Although most endometrial carcinomas are detected at low stage, there is still a significant mortality from the disease. In postmenopausal women, prolonged life expectancy, changes in reproductive behavior and prevalence of overweight and obesity, as well as hormone replacement therapy use, may partially account for the observed increases of incidence rates in some countries. In order to improve treatment and follow-up of endometrial carcinoma patients, the importance of various prognostic factors has been extensively studied. The identification of high-risk groups would make it possible to avoid unnecessary adjuvant treatment among pati...

Reverse Transcriptase Inhibitors Promising Against Renal Clear-Cell Carcinoma

Medscape Nephrology Headlines — Thu, 17 Jul 2008 15:26:19 +0100

The non-nucleoside reverse transcriptase (RT) inhibitors efavirenz and nevirapine induce cell differentiation and enhance the immunogenic phenotype in human renal clear-cell carcinoma (RCC), according to Italian researchers. Reuters Health Information (Source: Medscape Nephrology Headlines)

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Retroperitoneal laparoscopic radical nephrectomy: Intermediate oncological results

World Journal of Urology — Wed, 16 Jul 2008 05:57:56 +0100

Conclusions The laparoscopic retroperitoneal radical nephrectomy offers intermediate oncological results compatible with appropriate carcinological efficacy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00345-008-0306-8Authors Stéphane Larré, Henri Mondor University Hospital Department of Urology Créteil FranceChaker Kanso, Henri Mondor University Hospital Department of Urology Créteil FranceAlexandre De La Taille, Henri Mondor University Hospital Department of Urology Créteil FranceAndras Hoznek, Henri Mondor University Hospital Department of Urology Créteil FranceDimitrios Vordos, Henri Mondor University Hospital Department of Urology Créteil FranceRené Yiou, Henri Mondor University Hospital Department of Urology Créteil FranceClément-C...

Prognostic implication of endometriosis in clear cell carcinoma of the ovary.

Gynecologic Oncology — Wed, 16 Jul 2008 04:00:00 +0100

CONCLUSIONS: Our study suggests that the presence of endometriosis in patients with CCC of the ovary is associated with progression free and OS advantages with no difference in initial resectability. PMID: 18639330 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Clear cell carcinoma, not otherwise specified, of salivary glands: a clinicopathologic study of 4 cases and review of the literature.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Wed, 02 Jul 2008 04:00:00 +0100

We report the clinicopathologic and immunohistochemical features of 4 cases. The results were then analyzed collectively with the approximate 60 cases of CCC-NOS reported in the English-language literature to define the characteristics of this unusual neoplasm. Combining our cases with those in the literature, a total of 66 cases, confirms that CCC-NOS is a low-grade malignant neoplasm with distinctive clinical and pathologic features. It arises primarily in the minor salivary glands (91% of cases), particularly in the palate or base of tongue, and usually occurs in patients >30 years of age (mean 54.2 years) with a female-to-male ratio of 1.4:1; 12.3% of patients experience local recurrences, 19.3% develop positive regional lymph nodes, 8.8% have distant metastases, and 3.5% die of the...

[Renal cell carcinoma with colon metastases: an infrequent site for metastases.]

Cirugia y Cirujanos — Tue, 01 Jul 2008 04:00:00 +0100

Conclusions: RCC metastases are most frequent in lung, liver, and bone and less frequent in brain, skin, and soft tissue. Metachromic metastases are identified in the first to second year after nephrectomy in most cases. Survival of patients who present metastasis <1 year after nephrectomy is 33 months vs. patients who present metastasis after 1 year from nephrectomy (55 months). Metastatic clear cell carcinoma requires surgery and immunotherapy. Surgery is the first step for disease control and metastatecomies are indicated in localized disease or when one organ is affected and surgically accessible. PMID: 18778546 [PubMed - in process] (Source: Cirugia y Cirujanos)

A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma.

Yonsei Medical Journal — Sat, 28 Jun 2008 16:16:48 +0100

Conclusion: A comprehensive prognostic stratification model was developed to predict survival and stratify patients for prospective clinical trials. PMID: 18581596 [PubMed - in process] (Source: Yonsei Medical Journal)

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Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients?

Annals of Oncology — Wed, 25 Jun 2008 04:00:00 +0100

Conclusion: Our data suggest that patients with pTI–IIb CCC who underwent lymphadenectomy did not show a significant improvement in survival. There was no significant difference in the overall and disease-free survival rates in pTI–IIb CCC patients regardless of the completion of surgical staging lymphadenectomy. (Source: Annals of Oncology)

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Fertility and Sterility — Thu, 12 Jun 2008 23:00:00 +0100

Conclusion(s): Laparoscopic fertility-sparing staging in early ovarian malignancies is feasible and safe in selected and counseled patients and should be performed in experienced gynecological oncology centers trained in endoscopic procedures. (Source: Fertility and Sterility)

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies.

Fertility and Sterility — Thu, 12 Jun 2008 04:00:00 +0100

CONCLUSION(S): Laparoscopic fertility-sparing staging in early ovarian malignancies is feasible and safe in selected and counseled patients and should be performed in experienced gynecological oncology centers trained in endoscopic procedures. PMID: 18555237 [PubMed - as supplied by publisher] (Source: Fertility and Sterility)

Radical surgery effective for clear cell carcinoma of the cervix

MedWire News - Ob/Gyn — Tue, 10 Jun 2008 00:00:00 +0100

Despite the discontinuation of diethylstilbestrol during pregnancy, clear cell carcinoma of the cervix represents a growing proportion of cervical cancer cases, say researchers. (Source: MedWire News - Ob/Gyn)

Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1β

Modern Pathology AOP — Fri, 06 Jun 2008 04:00:00 +0100

Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1β Modern Pathology advance online publication, June 6, 2008. doi:10.1038/modpathol.2008.95 Authors: Lisa Kim, Jie Liao, Meng Zhang, Mark Talamonti, David Bentrem, Sambasiva Rao & and Guang-Yu Yang (Source: Modern Pathology AOP)

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Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?

Gynecologic Oncology — Thu, 05 Jun 2008 04:00:00 +0100

CONCLUSIONS: Although there is no worldwide criterion for FSS in CCC patients at present, it seems that, in selected patients, this surgical approach could be adopted. This should be investigated by additional studies in a larger series. PMID: 18538833 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Clinicopathologic Significance of Nuclear Grooves and Inclusions in Renal Cell Carcinoma: Image Database Construction and Quantitative Scoring.

Archives of Pathology and Laboratory Medicine — Sun, 01 Jun 2008 04:00:00 +0100

Conclusions.-Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas. Furthermore, nuclear inclusions might be an independent prognostic factor for clear cell RCC. PMID: 18517276 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)

[Vaginal metastasis from renal cell carcinoma]

Actas Urologicas Espanolas — Sun, 01 Jun 2008 04:00:00 +0100

We present a case of metastatic RCC in a 75-year-old woman, initially presenting with haematuria and vaginal pain. Workup further revealed a renal tumor and a vaginal mass. A nephrectomy and local vaginal excision were performed, leading to the diagnosis of metastatic RCC. This case illustrate the variability in RCC presentation. Also, because vaginal clear cell carcinoma is rare, all such lesions should be considered potentially renal in origin. PMID: 18655352 [PubMed - in process] (Source: Actas Urologicas Espanolas)

Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.

Biochemical and Biophysical Research communications — Sat, 31 May 2008 14:53:00 +0100

Authors: Ivanov SV, Ivanova AV, Salnikow K, Timofeeva O, Subramaniam M, Lerman MI Mutations in the VHL gene are associated with highly vascular tumors of kidney, brain, retina, and adrenal gland. The inability of the mutant VHL protein to destabilize HIF-1 plays a crucial role in malignant angiogenesis. VHL is also associated with ECM assembly but the molecular mechanisms of this activity remain unclear. We used expression arrays and cell lines with different VHL status to identify ECM-associated genes controlled by VHL. One of them, adhesion-associated TGFBI, was repressed by VHL and overexpressed in renal, gastrointestinal, brain, and other tumors. Analyzing the mechanism of TGFBI up-regulation in clear cell carcinoma, we identified a novel VHL target, a Kruppel-like transcriptional ...

Pediatric Renal Adenocarcinoma: A Review of Our Series.

Urology — Fri, 23 May 2008 04:00:00 +0100

CONCLUSIONS: Adenocarcinoma is an uncommon histopathologic type of pediatric renal tumor. In patients with hematuria and abdominal or flank pain, we should consider this tumor as a possible diagnosis. PMID: 18502480 [PubMed - as supplied by publisher] (Source: Urology)

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Immunohistochemical Detection of the von Hippel-Lindau Gene Product (pVHL) in Human Tissues and Tumors: A Useful Marker for Metastatic Renal Cell Carcinoma and Clear Cell Carcinoma of Ovary and Uterus

Medscape Urology Headlines — Wed, 21 May 2008 15:36:32 +0100

Regarding immunodetection of the von Hippel-Lindau (VHL) tumor suppressor gene product, is a specific rabbit polyclonal anti-pVHL antibody a useful diagnostic marker for renal and nonrenal neoplasms? American Journal of Clinical Pathology (Source: Medscape Urology Headlines)

Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Central European Journal of Medicine — Wed, 14 May 2008 06:19:34 +0100

Abstract We analyzed the clinicopathological features and survival rates of the patients with renal cell carcinoma younger than 50 years old. Between 2004 and 2007, 28 patients between 19–49 years underwent surgery for renal cell carcinoma. Presenting symptoms, type of the surgery performed, postoperative outcomes and duration of follow-up were recorded. Mean age was 41.5±7.6 years and 75% of patients were male. The tumor was symptomatic in 19(67.9%) and incidental in 9(32.1%) patients. Radical nephrectomy and nephron-sparing surgery were performed in 18(64.3%) and 10(35.7%) patients, respectively. The most common histologic type was clear cell(67.9%). The mean tumor diameters were 3.5±0.95 and 7.4±5.2 cm in the incidental and symptomatic groups, respectively(p=0.035)....

Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors.

Human Pathology — Mon, 12 May 2008 04:00:00 +0100

Authors: Romero-Sánchez M, Peiper SC, Evans B, Wang Z, Catasús L, Ribe A, Prat J, Giri JG A novel class of putative progestin binding proteins has been recently identified as potential mediators of rapid nongenomic hormone actions. The proteins designated membrane progestin receptor (mPR) alpha, beta, and gamma were initially discovered in fish and shown to have a role in oocyte maturation. The predicted multiple membrane spanning domain structure of the mPRs resembles that of heptahelical G-protein-coupled receptors. Phylogenetic analysis indicated that the mPRs belong to the large progestin and adiponectin Q receptor (PAQR) gene family. Based on the reported expression of the 3 mPRs in hormone-responsive tissues of the female reproductive tract and on the role of steroid ho...

Glycogen-rich clear cell carcinoma of the breast

World Journal of Surgical Oncology — Tue, 29 Apr 2008 04:00:00 +0100

Conclusions: Glycogen-rich clear cell carcinoma of the breast is a rare tumor, its clinical behavior reported to be rather aggressive so far, might varies depending on special characteristics such as low grade and strongly positive ER expression (Source: World Journal of Surgical Oncology)

P-glycoprotein activity in renal clear cell carcinoma

Urologic Oncology: Seminars and Original Investigations — Sun, 27 Apr 2008 23:00:00 +0100

Conclusions: Percentage of cells extruding daunorubicin in RCCC is elevated, indicating that P-gp activity may contribute to multidrug resistance in RCCC. (Source: Urologic Oncology: Seminars and Original Investigations)

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P-glycoprotein activity in renal clear cell carcinoma.

Urologic Oncology — Fri, 25 Apr 2008 04:00:00 +0100

CONCLUSIONS: Percentage of cells extruding daunorubicin in RCCC is elevated, indicating that P-gp activity may contribute to multidrug resistance in RCCC. PMID: 18440836 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas

Virchows Archiv — Wed, 16 Apr 2008 14:50:29 +0100

In conclusion, KAI-1 and p53 show inverse expression. The reduced KAI-1 expression may be the result of dysregulated p53 function and could be an important step in the endometrial carcinogenesis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00428-008-0608-7Authors Juliane Briese, University Clinic Hamburg-Eppendorf Section on Endocrinology and Metabolism of Ageing Hamburg GermanyHeinrich M. Schulte, University of Leeds, St. James’s Hospital Department of Pathology and Tumor Biology Beckett Street LS9 7TF Leeds UKMaria Sajin, Endokrinologikum Hamburg GermanyChristoph Bamberger, University Clinic Hamburg-Eppendorf Section on Endocrinology and Metabolism of Ageing Hamburg GermanyKatja Redlin, University of Leeds, St. James’s Hospital Department of Pathology and ...

[Genitourinary Imaging] Pixel Distribution Analysis: Can It be Used to Distinguish Clear Cell Carcinomas from Angiomyolipomas with Minimal Fat?

Continuous Publishing articles — Tue, 15 Apr 2008 04:00:00 +0100

Conclusion: Once AMLs with visible fat on CT images are excluded, pixel histogram analysis cannot be used to distinguish between AMLs and CCRCCs. © RSNA, 2008 (Source: Continuous Publishing articles)

Pixel Distribution Analysis: Can It be Used to Distinguish Clear Cell Carcinomas from Angiomyolipomas with Minimal Fat?

Radiology — Tue, 15 Apr 2008 04:00:00 +0100

Conclusion: Once AMLs with visible fat on CT images are excluded, pixel histogram analysis cannot be used to distinguish between AMLs and CCRCCs. (c) RSNA, 2008. PMID: 18413886 [PubMed - as supplied by publisher] (Source: Radiology)

Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study

Journal of Huazhong University of Science and Technology -- Medical Sciences -- — Fri, 11 Apr 2008 19:45:46 +0100

Content Type Journal ArticleDOI 10.1007/BF02888644Authors Chen Xue-shi, Wuhan Medical College Department of Pathology Wuhan Journal Journal of Huazhong University of Science and Technology -- Medical Sciences --Online ISSN 1993-1352Print ISSN 1672-0733 Journal Volume Volume 5 Journal Issue Volume 5, Number 2 / June, 1985 (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)

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Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers.

Gynecologic Oncology — Fri, 04 Apr 2008 04:00:00 +0100

CONCLUSIONS: Our data suggest that women with clear cell ovarian cancer present at a younger age, are more likely to be Asian, and have a poorer prognosis compared to serous cancers. PMID: 18395777 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Overexpression of osteopontin in clear cell carcinoma of the ovary: close association with HNF-1β expression

Histopathology — Thu, 03 Apr 2008 11:26:38 +0100

Histopathology, Volume 0, Issue 0, Page ???, November 2004. Kato N & Motoyama T(2008) HistopathologyOverexpression of osteopontin in clear cell carcinoma of the ovary: close association with HNF-1β expressionAims: Transcription factor hepatocyte nuclear factor (HNF)-1β is selectively expressed in clear cell ... (Source: Histopathology)

Clear cell carcinoma of the cervix: A multi-institutional review in the post-DES era.

Gynecologic Oncology — Wed, 02 Apr 2008 04:00:00 +0100

DISCUSSION: This series provides insight into the management of early stage CCCC in the post-DES era. Although these patients may be at slightly higher risk of nodal spread, clear cell histology by itself does not appear to portend a worse prognosis than squamous cell carcinoma of the cervix in the absence of traditional risk factors. Our data suggest that patients with low risk early stage CCCC may be managed with radical surgery alone, without the need for adjuvant chemotherapy or radiation. PMID: 18394687 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Immunohistochemical detection of the von Hippel-Lindau gene product (pVHL) in human tissues and tumors: a useful marker for metastatic renal cell carcinoma and clear cell carcinoma of the ovary and uterus.

American Journal of Clinical Pathology — Tue, 01 Apr 2008 04:00:00 +0100

Authors: Lin F, Shi J, Liu H, Zhang J, Zhang PL, Wang HL, Yang XJ, Schuerch C Genetic alteration of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary and sporadic clear cell renal cell carcinomas (RCCs). Inconsistent data on immunodetection of the VHL gene product (pVHL) in normal tissues and tumors have been reported. We immunohistochemically reevaluated the usefulness of a specific rabbit polyclonal anti-pVHL antibody in 531 cases of renal and nonrenal neoplasms and normal tissues. Positive immunostaining was observed in nearly 100% of primary renal neoplasms, 95% of metastatic RCCs, and 90% of clear cell carcinomas of the ovary and uterus. In normal tissues, positive immunoreactivity was observed only in renal tubules, exocrine pancreas, islets, and bil...

Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma

Cancer Science — Sat, 29 Mar 2008 00:53:28 +0100

Cancer Science, Volume 99, Issue 4, Page 653-658, April 2008. Clear cell carcinoma (CCC) accounts for 4% to 12% of epithelial ovarian cancer in Western countries and, for some unknown reasons, it comprises more than 20% of such cancers in Japan. CCC shows unique clinical features such as a high incidence of stage I ... (Source: Cancer Science)

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Oncofetal Protein Glypican-3 Distinguishes Yolk Sac Tumor From Clear Cell Carcinoma of the Ovary.

The American Journal of Surgical Pathology — Wed, 26 Mar 2008 23:38:27 +0100

Page: 600DOI: 10.1097/PAS.0b013e31815a565aAuthors: Esheba, Ghada E. MSc; Pate, Lisa L. MD; Longacre, Teri A. MD (Source: The American Journal of Surgical Pathology)

Chondromatous differentiation in clear cell carcinoma of the ovary: a rare finding challenging the differential diagnosis

Archives of Gynecology and Obstetrics — Sat, 15 Mar 2008 09:14:30 +0100

Conclusion A rare case of benign appearing chondromatous differentiation in an ovarian clear cell carcinoma of the ovary is described, and the significance of this finding is discussed. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-008-0624-5Authors Metin Akbulut, Pamukkale University Department of Pathology, School of Medicine Denizli TurkeyOsman Zekioglu, Ege University Department of Pathology, School of Medicine Bornova, Izmir TurkeyMustafa Cosan Terek, Ege University Department of Obstetrics and Gynecology, School of Medicine Bornova, Izmir TurkeyNecmettin Ozdemir, Ege University Department of Pathology, School of Medicine Bornova, Izmir Turkey Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source...

BMI-1 Expression is Inversely Correlated with the Grading of Renal Clear Cell Carcinoma.

Pathology Oncology Research — Sat, 15 Mar 2008 04:00:00 +0100

Authors: Kozakowski N, Soleiman A, Pammer J BMI-1 regulates cell proliferation and differentiation, is involved in stem cell maintenance and can act as an oncogene. We investigated BMI-1 expression in healthy normal kidney and in 77 renal tumours by immunohistochemistry, and correlated it with tumour differentiation. BMI-1 could regularly be demonstrated in distal tubules and in Bowman's capsule, whereas it was mostly lacking in proximal tubules, indicating that it may rather be a differentiation marker of different renal cell populations than a stem cell marker. In contrast to previous studies demonstrating a correlation between BMI-1 expression and malignancy, we showed that its expression was inversely correlated with the differentiation grade of clear cell carcinoma. Furthermore, d...

Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney.

European Urology — Tue, 11 Mar 2008 04:00:00 +0100

CONCLUSIONS: Lower blood levels of adiponectin are positively associated with clear-cell RCC aggressiveness and could potentially be used as a biomarker. PMID: 18343565 [PubMed - as supplied by publisher] (Source: European Urology)