MedWorm: Colon Cancer

Feedback loop explains inflammatory effect on intestinal lining

ScienceDaily Headlines — Sat, 20 Mar 2010 09:00:00 +0100

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells. Researchers have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations. Interfering with one component of the feedback loop -- a protein called "dickkopf 1" -- may aid in controlling inflammatory bowel diseases. (Source: ScienceDaily Headlines)

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Inflammatory Effect On Intestinal Lining Explained By Feedback Loop

Health News from Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a significantly higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells. Researchers at Emory University School of Medicine have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations... (Source: Health News from Medical News Today)

Inflammatory Effect On Intestinal Lining Explained By Feedback Loop

Immune System / Vaccines News From Medical News Today — Sat, 20 Mar 2010 07:00:00 +0100

survivalratebystage

About.com Colon Cancer — Sat, 20 Mar 2010 00:00:00 +0100

Colon cancer survival rates vary by stage. Getting the facts about survival rates by stage will help you make informed decisions about your colon cancer care. When diagnosed early, colon cancer is highly curable. Even when diagnosed at later stages, new colon cancer treatments are improving survival for people with more advanced disease. (Source: About.com Colon Cancer)

Colon Cancer Drugs Linked to Survival, Considerable Expense

Modern Medicine — Sat, 20 Mar 2010 00:00:00 +0100

New chemotherapy drugs for metastatic colon cancer are associated with longer survival, but at steep costs that Medicare may have difficulty covering in the future, according to research published online March 16 in the Archives of Internal Medicine. (Source: Modern Medicine)

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK

AJP: Gastrointestinal and Liver Physiology — Fri, 19 Mar 2010 16:55:08 +0100

Progastrin and insulin-like growth factors (IGFs) stimulate hyperproliferation of intestinal epithelial cells (IECs) via endocrine/paracrine routes; hyperproliferation is a known risk factor for colon carcinogenesis. In the present study, inhibitory potency of curcumin in the presence or absence of progastrin and/or IGF-II was examined. Progastrin and IGF-II significantly increased proliferation of an immortalized IEC cell line, IEC-18, whereas curcumin decreased the proliferation in a dose-dependent manner. IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and reversed proapoptotic effects of curcumin by >80%; progastrin was relatively ineffective toward reversing proapoptotic effects of curcumin. IEC-18 clones were generated to ...

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Metastases in odontogenic cysts: literature review and case presentation

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Fri, 19 Mar 2010 15:22:23 +0100

Malignant tumors in the oral cavity are relatively rare. About 5% of all malignant growths in the body are localized in the oral cavity. The vast majority of oral malignancies are primary tumors with squamous cell carcinoma being the most frequent and sarcomas occurring very seldom. Secondary tumors caused by hematogenous spread arising from a tumor localized elsewhere in the body are extremely rare. About 1% of all oral cancers are metastases to the jawbones and the surrounding soft tissues. Metastases to the jaws are mainly caused by malignant tumors of the breast, lung, kidney, bone, and colon. They occur in the late state of the disease and are regularly detected by staging examinations including scintigraphy. Even more rare are metastases into odontogenic cysts. Odontogenic cysts incl...

Older patients with colon cancer able to tolerate adjuvant chemotherapy

HemOncToday.com — Fri, 19 Mar 2010 09:32:00 +0100

(Source: HemOncToday.com)

Tennessee State Legislators Mark National Colon Cancer Month With Briefing On Revolutionary New Colon Cancer Test

Health News from Medical News Today — Fri, 19 Mar 2010 00:00:00 +0100

EDP Biotech, a Knoxville-based company today briefed Tennessee state legislators on its revolutionary ColoMarker™ colon cancer test which potentially could save 50,000 lives and more than $12 billion in healthcare costs annually in the U.S. Legislators were also provided the opportunity to personally experience the ColoMarker™ test by enrolling in the control study group for EDP's latest research. The briefing and test were scheduled to coincide with National Colon Cancer Month, which is being observed throughout March 2010... (Source: Health News from Medical News Today)

Tennessee State Legislators Mark National Colon Cancer Month With Briefing On Revolutionary New Colon Cancer Test

Cancer / Oncology News From Medical News Today — Fri, 19 Mar 2010 00:00:00 +0100

[Seminar] Colorectal cancer

LANCET — Fri, 19 Mar 2010 00:00:00 +0100

Substantial progress has been made in colorectal cancer in the past decade. Screening, used to identify individuals at an early stage, has improved outcome. There is greater understanding of the genetic basis of inherited colorectal cancer and identification of patients at risk. Optimisation of surgery for patients with localised disease has had a major effect on survival at 5 years and 10 years. For rectal cancer, identification of patients at greatest risk of local failure is important in the selection of patients for preoperative chemoradiation, a strategy proven to improve outcomes in these patients. Stringent postoperative follow-up helps the early identification of potentially radically treatable oligometastatic disease and improves long-term survival. Treatment with adjuvant fluorop...

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Health Buzz: Gays Kept Out of Clinical Trials

U.S. News - Health — Thu, 18 Mar 2010 17:21:00 +0100

The big risk in ignoring erectile dysfunction; the problem with a blood test for colon cancer. (Source: U.S. News - Health)

Inflammation and Cancer - News on Genetics, Prognosis, and Prevention

DF/HCC: Latest News — Thu, 18 Mar 2010 15:10:14 +0100

Cancer Epidemiology Seminar SeriesWednesday, March 31st, 201012:30 1:20 p.m. Kresge 502Harvard School of Public HealthCornelia Ulrich, MS, PhDFull Member, Fred Hutchinson Cancer Research Center, Cancer Prevention ProgramDirector, National Center for Tumor Diseases (NCT) HeidelbergHead and Full Professor, Division of Preventive Oncology, German Cancer Research Center (DKFZ)Inflammation and Cancer - News on Genetics, Prognosis, and Prevention"This talk will illustrate the influence of inflammatory processes on cancer risk and prognosis, using examples from colon and breast cancer research. The potential for prevention strategies with exercise interventions will be discussed. Dr. Ulrich will provide an evaluation of genetically targeted prevention strategies for NSAIDs. (Source: DF/...

Research Team Demonstrate For The First Time The Important Role Of 2 Proteins In The Process Of Inflammation And Colon Cancer

Health News from Medical News Today — Thu, 18 Mar 2010 13:00:00 +0100

Every day, our gut comes in contact with bacteria, inducing an inflammatory response that is tolerated and controlled. Sometimes the control of inflammation is lost and this can lead to inflammatory bowel disease that may predispose to colon cancer. Caspase-1, an important protein involved in the mechanism of inflammation, has long been believed to be one of the culprits behind excessive inflammation in the colon. Dr. Saleh's team suggests the opposite in a new study... (Source: Health News from Medical News Today)

Research Team Demonstrate For The First Time The Important Role Of 2 Proteins In The Process Of Inflammation And Colon Cancer

Immune System / Vaccines News From Medical News Today — Thu, 18 Mar 2010 13:00:00 +0100

March Is Colorectal Cancer Awareness Month - No. 3 Killer Of Women Is Preventable, Treatable, And Beatable

Health News from Medical News Today — Thu, 18 Mar 2010 12:00:00 +0100

In recognition of Colorectal Cancer Awareness Month, The American College of Obstetricians and Gynecologists reminds ob-gyns and women that the best defense against colorectal cancer-the third leading cause of cancer death among women in the US-is getting screened. The College recommends that all women undergo colorectal cancer screening beginning at age 50, or earlier if they have risk factors for the disease. Colorectal cancer (often referred to as colon cancer) is a slow-growing cancer that affects the cells in the colon and rectum and can spread to other parts of the body... (Source: Health News from Medical News Today)

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Genetic variations influence statin efficacy for lowering colon cancer risk

Cancer Network — Thu, 18 Mar 2010 12:00:00 +0100

Four years ago, at least five years of statin use was found to be associated with a 53% reduction in the risk of colorectal cancer and that association still stands, according to a coauthor of one of the initial studies to make the statin-cancer connection. (Source: Cancer Network)

Room 101: where services go to die

BMJ Online First — Thu, 18 Mar 2010 11:44:07 +0100

(Source: BMJ Online First)

Study Evaluates Costs And Benefits Associated With New Colon Cancer Therapies

Health News from Medical News Today — Thu, 18 Mar 2010 09:00:00 +0100

New chemotherapy agents appear associated with improvements in survival time for patients with metastastic colorectal cancer, but at substantial cost. David H. Howard, Ph.D., and colleagues at Emory University, Atlanta, used a cancer registry database to measure trends in life expectancy and lifetime medical costs in 4,665 patients age 66 and older diagnosed with metastastic colon cancer between 1995 and 2005. Patients were classified according to whether they received one or more of the six chemotherapeutic agents approved for the treatment of metastastic colon cancer between 1996 to 2004... (Source: Health News from Medical News Today)

Study Evaluates Costs And Benefits Associated With New Colon Cancer Therapies

Cancer / Oncology News From Medical News Today — Thu, 18 Mar 2010 09:00:00 +0100

Older Patients With Colon Cancer Less Likely To Receive Chemotherapy After Surgery, And Have Fewer Adverse Events

Health News from Medical News Today — Thu, 18 Mar 2010 08:00:00 +0100

Even though older patients with colon cancer are less likely to receive chemotherapy following surgery because of concerns of adverse events, new research indicates that when they do receive this treatment, it is less toxic and of shorter duration than therapy younger patients receive, and older patients experience fewer adverse events, according to a study in the March 17 issue of JAMA, a theme issue on cancer. Study co-author Robert H. Fletcher, M.D., M.Sc., of Harvard Medical School, Boston, presented the findings of the study at a JAMA media briefing... (Source: Health News from Medical News Today)

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Older Patients With Colon Cancer Less Likely To Receive Chemotherapy After Surgery, And Have Fewer Adverse Events

Cancer / Oncology News From Medical News Today — Thu, 18 Mar 2010 08:00:00 +0100

Even though older patients with colon cancer are less likely to receive chemotherapy following surgery because of concerns of adverse events, new research indicates that when they do receive this treatment, it is less toxic and of shorter duration than therapy younger patients receive, and older patients experience fewer adverse events, according to a study in the March 17 issu... (Source: Cancer / Oncology News From Medical News Today)

Costs And Benefits Of New Chemotherapy Drugs Evaluated By Study

Health News from Medical News Today — Thu, 18 Mar 2010 07:00:00 +0100

New chemotherapy agents appear associated with improvements in survival time for patients with metastatic colorectal cancer but at substantial cost. David H. Howard, PhD, and colleagues at Emory University's Rollins School of Public Health (RSPH), used a cancer registry database to measure trends in life expectancy and lifetime medical costs in 4,665 patients age 66 and older diagnosed with metastatic colon cancer between 1995 and 2005... (Source: Health News from Medical News Today)

Colon cancer treatment for older patients often less aggressive than recommended, study finds

UCLA Newsroom: Health Sciences — Thu, 18 Mar 2010 07:00:00 +0100

New results from a major initiative on the quality of cancer care in the United States show that patients with a common type of colon cancer, especially older patients, often do not receive the aggressive treatment with chemotherapy that research shows is associated with better survival. Led by researchers from UCLA and the RAND Corp., a nonprofit research organization, the study is among the first to track how findings from specialty research trials are applied in diverse practices in the community, where a wider variety of patients are treated. The results will appear in the March 17 edition of the Journal of the American Medical Association, which is devoted to developments in cancer care. The study indicates that older patients, and to some extent youn...

Dispatch: Cancer Screening, E-Cigs, First Lady on Food, Taxing "Pizza"

Health Facts and Fears — Thu, 18 Mar 2010 05:00:00 +0100

In its coverage of a new blood test that is being billed as a method to detect colon cancer, U.S. News is appropriately skeptical ... (Source: Health Facts and Fears)

Feedback loop explains inflammatory effect on intestinal lining

EurekAlert! - Medicine and Health — Thu, 18 Mar 2010 04:00:00 +0100

(Emory University) Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells.Researchers have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations. Interfering with one component of the feedback loop -- a protein called "dickkopf 1" -- may aid in controlling inflammatory bowel diseases. (Source: EurekAlert! - Medicine and Health)

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Mayo Researchers Link Obesity To Worse Outcome In Patients Being Treated For Colon Cancer

Cancercompass News: Colorectal Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Patients With Irritable Bowel Syndrome Not More Likely To Develop Polyps Or Colon Cancer, U-M Study Says

Cancercompass News: Colorectal Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Only One State Passed Legislation In 2009 Requiring Insurers To Cover Costs Of Colon Cancer Screening

Cancercompass News: Colorectal Cancer — Thu, 18 Mar 2010 00:00:00 +0100

Progress towards nationwide, state-mandated coverage of colon cancer screening according to accepted medical guidelines has slowed to a crawl as state legislators await the outcome of the health care reform debate at the federal level, a coalition of public health associations and medical professional societies reported. (Source: Cancercompass News: Colorectal Cancer)

A Blood Test for Colon Cancer Sounds Great—But It's Short on Proof

U.S. News - Health — Wed, 17 Mar 2010 19:06:00 +0100

The maker says it can find cancer early, but that’s a far cry from preventing colorectal cancer deaths (Source: U.S. News - Health)

Interventional Radiology Treatment Destroys Colon Cancer Locally, Extends Life

Health News from Medical News Today — Wed, 17 Mar 2010 13:00:00 +0100

Approximately half of Americans living with colorectal cancer will develop liver metastases at some point during the course of their disease. Radiofrequency ablation, a minimally invasive treatment that applies heat directly in the tumor causing cancer cell death with minimal associated injury to the surrounding healthy liver, contributes to prolongation of their life by nearly three years, noted researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla... (Source: Health News from Medical News Today)

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Interventional Radiology Treatment Destroys Colon Cancer Locally, Extends Life

Liver Disease / Hepatitis News From Medical News Today — Wed, 17 Mar 2010 13:00:00 +0100

Approximately half of Americans living with colorectal cancer will develop liver metastases at some point during the course of their disease... (Source: Liver Disease / Hepatitis News From Medical News Today)

Effective Rx for KRAS-mutated colon cancer

Cancer Network — Wed, 17 Mar 2010 12:00:00 +0100

A primer on managing the chemorefractory patient from Eric Van Cutsem, MD, PhD. (Source: Cancer Network)

Older Colon Cancer Patients Less Likely to Get Chemo

MedicineNet Cancer General — Wed, 17 Mar 2010 07:00:00 +0100

Title: Older Colon Cancer Patients Less Likely to Get ChemoCategory: Health NewsCreated: 3/16/2010 12:10:00 PMLast Editorial Review: 3/17/2010 (Source: MedicineNet Cancer General)

Should Colon Cancer Treatment be More Aggressive?

Medical Headlines From Ivanhoe.com — Wed, 17 Mar 2010 05:00:00 +0100

(Ivanhoe Newswire) -- Patients with a common type of colon cancer -- especially older patients -- often are not treated as aggressively with chemotherapy as research shows is necessary to improve survival. (Source: Medical Headlines From Ivanhoe.com)

Could regulating intestinal inflammation prevent colon cancer?

EurekAlert! - Medicine and Health — Wed, 17 Mar 2010 04:00:00 +0100

(McGill University Health Centre) Every day, our gut comes in contact with bacteria, inducing an inflammatory response that is tolerated and controlled. Sometimes the control of inflammation is lost and this can lead to inflammatory bowel disease that may predispose to colon cancer. Caspase-1, an important protein involved in the mechanism of inflammation, has long been believed to be one of the culprits behind excessive inflammation in the colon. Dr. Saleh's team suggests the opposite in a new study. (Source: EurekAlert! - Medicine and Health)

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Could regulating intestinal inflammation prevent colon cancer?

ScienceDaily Headlines — Wed, 17 Mar 2010 04:00:00 +0100

Every day, our gut comes in contact with bacteria, inducing an inflammatory response that is tolerated and controlled. Sometimes the control of inflammation is lost and this can lead to inflammatory bowel disease that may predispose to colon cancer. Caspase-1, an important protein involved in the mechanism of inflammation, has long been believed to be one of the culprits behind excessive inflammation in the colon. Researchers suggest the opposite in a new study. (Source: ScienceDaily Headlines)

Global Gene Expression Analysis Reveals Differences in Cellular Responses to Hydroxyl- and Superoxide Anion Radical-Induced Oxidative Stress in Caco-2 Cells

Toxicological Sciences — Wed, 17 Mar 2010 00:49:57 +0100

Reactive oxygen species–induced oxidative stress in the colon is involved in inflammatory bowel diseases and suggested to be associated with colorectal cancer risk. However, our insight in molecular responses to different oxygen radicals is still fragmentary. Therefore, we studied global gene expression by an extensive time series (0.08, 0.25, 0.5, 1, 2, 4, 8, 16, or 24 h) analyses in human colon cancer (caco-2) cells after exposure to H2O2 or the superoxide anion donor menadione. Differences in gene expression were investigated by hybridization on two-color microarrays against nonexposed time-matched control cells. Next to gene expression, correlations with related phenotypic markers (8-oxodG levels and cell cycle arrest) were investigated. Gene expression analysis resulted in 1404 ...

Experts' guide to saving money in health

BMJ Online First — Wed, 17 Mar 2010 00:05:45 +0100

(Source: BMJ Online First)

Vitamin B6 Ingredient Linked To Lower Colorectal Cancer Risk

Cancercompass News: Colorectal Cancer — Wed, 17 Mar 2010 00:00:00 +0100

Vitamin B6 appears to play a beneficial role in preventing colon cancer, a study published Tuesday concluded. Researchers led by Susanna Larsson of Sweden's National Institute of Environmental medicine traced the beneficial effects to pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6. (Source: Cancercompass News: Colorectal Cancer)

Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells

Journal of Peptide Science — Wed, 17 Mar 2010 00:00:00 +0100

MyoD is a DNA-binding protein capable of specific interactions that involve the helix-loop-helix (HLH) domain. The HLH motif of MyoD can form oligomers with the HLH motif of Id1 (the inhibitor of DNA-binding proteins) that folds into a highly stable helical conformation stabilized by the self-association. The Id family consists of four related proteins that contain a highly conserved dimerization motif known as the HLH domain. In signaling pathways, Id proteins act as dominant negative antagonists of the basic helix-loop-helix (bHLH) family of transcription factors which play important roles in cellular development, proliferation, and differentiation. The mechanism of Id proteins is to antagonize bHLH proteins by binding as dominant negative HLH proteins to form high-affinity heterodimers ...

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High pyridoxine intake associated with reduced risk of colorectal cancer

NeLM - News — Wed, 17 Mar 2010 00:00:00 +0100

Source: JAMA Area: News A meta-analysis of prospective studies found an inverse association between risk of colorectal cancer and pyridoxine intake or pyridoxal 5'-phosphate (PLP) blood level. Pyridoxine and related substances, collectively known as vitamin B6, are converted in the body to PLP, a co-enzyme essential in a wide range of enzymatic reactions. Many of these are potentially related to suppression of carcinogenesis. The authors of this meta-analysis aimed to determine whether there was any evidence from prospective published studies for an association between vitamin B6 and risk of colorectal cancer. They carried out a literature search for prospective trials examining vitamin B6 intake or blood (plasma or serum) levels of PLP, where colorectal, colon, or rectal cance...

Observational study: Adjuvant chemotherapy in older patients with stage III colon cancer

NeLM - News — Wed, 17 Mar 2010 00:00:00 +0100

This study used data from patients who participated in the Cancer Care Outcomes Research and Surveillance (CanCORS) study. This US study examined care delivered to population- and health system-based cohorts of patients, including 4713 newly diagnosed with colorectal cancer between 2003 and 2005 and followed up for as long as 15 months. The current ... (Source: NeLM - News)

SIR: Radiology Treatment in Liver Metastases Prolongs Life

Modern Medicine — Wed, 17 Mar 2010 00:00:00 +0100

Minimally invasive radiofrequency ablation to kill colon cancer cells that have metastasized to the liver can extend a patient's life by nearly three years, according to research presented at the Annual Scientific Meeting of the Society of Interventional Radiology, held from March 13 to 18 in Tampa, Fla. (Source: Modern Medicine)

Age likely a factor in colon cancer chemotherapy

Reuters: Health — Tue, 16 Mar 2010 22:48:27 +0100

WASHINGTON (Reuters) - Older patients with colon cancer are less likely to receive chemotherapy after surgery than younger people but have fewer serious side-effects when they do get the treatment, U.S. researchers said on Tuesday. (Source: Reuters: Health)

SIR: RF ablation treatment extends life of colon cancer patients

Health Imaging News — Tue, 16 Mar 2010 16:00:33 +0100

Radiofrequency ablation, a minimally invasive treatment that applies heat directly to the tumor causing cancer cell death with minimal associated injury to the surrounding healthy liver, contributes to the prolongation of patients' lives by nearly three years, according to a study presented at the Society of Interventional Radiology's (SIR) 35th annual scientific meeting in Tampa, Fla. this week. (Source: Health Imaging News)

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SIR: RF ablation treatment extends life of colon cancer patients

Health Imaging News — Tue, 16 Mar 2010 16:00:33 +0100

Older Colon Cancer Patients Less Likely to Get Chemo

MedlinePlus Health News — Tue, 16 Mar 2010 16:00:00 +0100

Study found one in two went without, while 87% of younger patients got it after surgery Source: HealthDay Related MedlinePlus Pages: Cancer Chemotherapy, Colorectal Cancer (Source: MedlinePlus Health News)

A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies

Histochemistry and Cell Biology — Tue, 16 Mar 2010 14:49:23 +0100

In conclusion, tumours differ in the pattern of Fn or Tn-C isoform positivity in the vessel wall, potentially representing a tumour type specific endothelial cell–tumour cell–stromal cell interaction. Carcinoma cells themselves are involved in vascular Tn-C matrix organization. Up to antigen distribution, Fn and Tn-C domain antibodies may serve as vehicles for antiangiogenetic and antifibrotic agents; oncFn/oncTn-C based targeting should be adapted individually. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00418-010-0685-yAuthors Alexander Berndt, University Hospital Jena Institute of Pathology Ziegelmühlenweg 1 07743 Jena GermanyRobert Köllner, University Hospital Jena Institute of Pathology Ziegelmühlenweg 1 07743 Jena GermanyPetra Richter, University ...

Chemo Use Spotty in Older Colon Cancer Patients (CME/CE)

MedPage Today Gastroenterology — Tue, 16 Mar 2010 14:00:00 +0100

Older colon cancer patients tended to undergo milder chemotherapy regimes after surgery than younger patients, with fewer adverse events, but they may not have reaped the full benefits of the treatment, researchers found. (Source: MedPage Today Gastroenterology)

The Value of New Chemotherapeutic Agents for Metastatic Colorectal Cancer [Original Investigation]

Archives of Internal Medicine — Tue, 16 Mar 2010 13:55:32 +0100

Conclusions New chemotherapeutic agents are associated with improvements in survival time but also with substantial costs. The cost-effectiveness ratio for these drugs as a group is below commonly cited estimates of the willingness-to-pay for a life-year. However, open-ended coverage policies for new chemotherapeutic agents may prove difficult to sustain as costs continue to rise.Published online March 16, 2010 (doi:10.1001/archinternmed.2010.36). (Source: Archives of Internal Medicine)

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Adjuvant Chemotherapy Use and Adverse Events Among Older Patients With Stage III Colon Cancer [Original Contribution]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

Conclusion Among patients with stage III colon cancer who underwent surgical resection and received adjuvant chemotherapy, older patients in the community received less-toxic and shorter chemotherapy regimens, and those treated had fewer adverse events than younger patients. (Source: JAMA)

Vitamin B6 and Risk of Colorectal Cancer: A Meta-analysis of Prospective Studies [Review]

JAMA — Tue, 16 Mar 2010 13:50:41 +0100

Conclusion Vitamin B6 intake and blood PLP levels were inversely associated with the risk of colorectal cancer in this meta-analysis. (Source: JAMA)

Living longer: Colon cancer patients gain time with radiofrequency ablation treatment

EurekAlert! - Social and Behavioral Science — Tue, 16 Mar 2010 04:00:00 +0100

(Society of Interventional Radiology) Approximately half of Americans living with colorectal cancer will develop liver metastases at some point during the course of their disease. Radiofrequency ablation, a minimally invasive treatment that applies heat directly in the tumor causing cancer cell death with minimal associated injury to the surrounding healthy liver, contributes to prolongation of their life by nearly three years, note researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla. (Source: EurekAlert! - Social and Behavioral Science)

Study evaluates costs and benefits of new chemotherapy drugs

EurekAlert! - Medicine and Health — Tue, 16 Mar 2010 04:00:00 +0100

(Emory University) New chemotherapy agents appear associated with improvements in survival time for patients with metastatic colorectal cancer but at substantial cost.David H. Howard, Ph.D., and colleagues at Emory University's Rollins School of Public Health, used a cancer registry database to measure trends in life expectancy and lifetime medical costs in 4,665 patients age 66 and older diagnosed with metastatic colon cancer between 1995 and 2005. (Source: EurekAlert! - Medicine and Health)

Study evaluates costs and benefits associated with new colon cancer therapies

EurekAlert! - Medicine and Health — Tue, 16 Mar 2010 04:00:00 +0100

(JAMA and Archives Journals) New chemotherapy agents appear associated with improvements in survival time for patients with metastastic colorectal cancer, but at substantial cost, according to a report in the March 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. (Source: EurekAlert! - Medicine and Health)

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Older patients with colon cancer less likely to receive chemotherapy after surgery

EurekAlert! - Medicine and Health — Tue, 16 Mar 2010 04:00:00 +0100

(JAMA and Archives Journals) Even though older patients with colon cancer are less likely to receive chemotherapy following surgery because of concerns of adverse events, new research indicates that when they do receive this treatment, it is less toxic and of shorter duration than therapy younger patients receive, and older patients experience fewer adverse events, according to a study in the March 17 issue of JAMA, a theme issue on cancer. (Source: EurekAlert! - Medicine and Health)

Colon cancer treatment frequently is less aggressive than recommended, RAND-UCLA study finds

EurekAlert! - Medicine and Health — Tue, 16 Mar 2010 04:00:00 +0100

(RAND Corporation) New results from a major initiative on the quality of cancer care in the United States show that patients with a common type of colon cancer -- especially older patients -- often are not treated as aggressively with chemotherapy as research shows is necessary. The study is among the first to track how findings from research trials are applied in diverse practices in the community. (Source: EurekAlert! - Medicine and Health)

A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes

BMC Cancer — Tue, 16 Mar 2010 00:00:00 +0100

Conclusions: This study describes a high throughput technology that can be used to interrogate DNAs isolated from routinely processed FFPET and identifies the specific mutations that are common to colon cancer. The development of this technology and the ColoCarta panel may provide a mechanism for rapid screening of mutations in clinically relevant genes like KRAS, PIK3CA, and BRAF.Trial Registration: ClinicalTrials.gov: NSABP C-07: NCT00004931 (Source: BMC Cancer)

Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration

British Journal of Cancer AOP — Tue, 16 Mar 2010 00:00:00 +0100

Authors: G Sonvilla, S Allerstorfer, C Heinzle, S Stättner, J Karner, M Klimpfinger, F Wrba, H Fischer, C Gauglhofer, S Spiegl-Kreinecker, B Grasl-Kraupp, K Holzmann, M Grusch, W Berger & B Marian (Source: British Journal of Cancer AOP)

Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis

Radiation Oncology — Tue, 16 Mar 2010 00:00:00 +0100

Conclusions: Pro-inflammatory cytokines play a key role in radiotherapy-induced gastrointestinal mucositis in the sub-acute onset setting. (Source: Radiation Oncology)

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Seniors on Adjuvant Chemo Have Less Toxic Regimens

Modern Medicine — Tue, 16 Mar 2010 00:00:00 +0100

Older patients with colon cancer who receive adjuvant chemotherapy tend to have less-toxic and shorter chemotherapy regimens and suffer fewer adverse events than younger patients, according to a study in the March 17 issue of the Journal of the American Medical Association. (Source: Modern Medicine)

Antioxidant and NF-kappaB inhibitory constituents isolated from Morchella esculenta.

Natural Product Research — Tue, 16 Mar 2010 00:00:00 +0100

Authors: Kim JA, Lau E, Tay D, De Blanco EJ Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells. The methylene chloride extract, which showed the highest antioxidant activity, led to the isolation of four fungal sterols, 1-4, and trilinolein (5), in addition to methyl myristate (6), 1-linoleoylglycerol (7), and ceramide (8). The isolated compounds were identified through the analysis of various spectroscopic methods. In the hydroxyl radical assay, 5-dihydroergosterol exhibited significant antioxidant activity. All compounds isolated were also tested using an enzyme-based Elisa NF-kappaB assay. Fungal sterols and trilinolein showed significant inhibition of NF-kappaB ac...

NCCN Colon Cancer Guideline Update Includes BRAF Testing, Adjuvant Chemotherapy

Medscape Today Headlines — Mon, 15 Mar 2010 20:48:21 +0100

Recommendations on the clinical use of the BRAF testing and on adjuvant therapies highlight this year's NCCN update to its colon cancer guidelines. Medscape Medical News (Source: Medscape Today Headlines)

Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin

Cancer Research — Mon, 15 Mar 2010 04:07:29 +0100

Evidence of chemopreventive activity against colon cancer is provided for the first time for a natural product derived from a milk thistle plant. (Source: Cancer Research)

The relation between different dimensions of alcohol consumption and burden of disease: an overview

Addiction — Mon, 15 Mar 2010 00:00:00 +0100

Conclusions Overall, these findings indicate that alcohol impacts many disease outcomes causally, both chronic and acute, and injuries. In addition, a pattern of heavy episodic drinking increases risk for some disease and all injury outcomes. Future studies need to address a number of methodological issues, especially the differential role of average volume versus drinking pattern, in order to obtain more accurate risk estimates and to understand more clearly the nature of alcohol[ndash]disease relationships. (Source: Addiction)

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Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity

Journal of Cellular Physiology — Mon, 15 Mar 2010 00:00:00 +0100

Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded protein response (UPR), which enhances cell survival by induction of the stress proteins. We have established a screening method to discover anticancer agents that could preferentially inhibit tumor cell viability under glucose-deprived conditions. Here we identify arctigenin (ARC-G) as an active compound that shows selective cytotoxicity and inhibits the UPR during glucose deprivation. Indeed, ARC-G blocked expression of UPR target genes such as phosphorylated-PERK, ATF4, CHOP, ...

To Beat Colon Cancer, Munch on Magnesium

About.com Colon Cancer — Mon, 15 Mar 2010 00:00:00 +0100

Plenty of studies tell us that diet and nutrition can affect colon cancer risk. Now researchers are honing in on which nutrients may be an important part of the colon cancer-food connection. For the study Japanese researchers collected diet and health information from 87,117 people with an average age of 57. They followed this group for about eight years to see who developed colon cancer and whether this was related to a person's dietary habits. Men with the highest average intake of magnesium had 52% lower risk of developing colon cancer compared with men getting the least magnesium. The men with reduced colon cancer risk were getting at least 327 milligrams (mg) of magnesium per day. What About Magnesium Supplements? Remember that this study focused on magnesium from food sources, no...

Location in the large bowel influences the APC mutations observed in FAP adenomas

Familial Cancer — Sun, 14 Mar 2010 11:28:58 +0100

This study aimed to investigate whether colonic location also influences the APC mutation spectrum in FAP. 127 1–2 mm mildly dysplastic adenomas from 5 patients with a codon 1309 germline mutation, and 41 from 3 patients with mutations proximal to codon 1265, were analysed to assess the frequency of loss of heterozygosity (LOH). We chose polyps from different locations in the colon. Immunohistochemistry for beta-catenin, caspase-3 and Ki-67 was performed to assess Wnt pathway activation, apoptosis and proliferation. In polyps from patients with a 1309 mutation, the frequency of LOH showed a gradient from rectum (highest) to caecum/ascending colon (lowest), but this was not present in patients with proximal germline APC mutations. Crypt-by-crypt analysis confirmed the LOH findi...

Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case–control study in an Indian population

Journal of Cancer Research and Clinical Oncology — Sun, 14 Mar 2010 11:26:27 +0100

Conclusions The combined effects of putative risk alleles/genotypes for different DNA repair pathways may strengthen the susceptibility to rectal cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0809-8Authors Jingwen Wang, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanYang Zhao, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanJing Jiang, The First Hospital, Jilin University Department of Hematology and Oncology Changchun ChinaVendhan Gajalakshmi, Epidemiological Research Center Chennai IndiaKiyonori Kuriki, University of Shizuoka Hygiene and Preventive Medicine, School of Food and Nutritional Sc...

Gardening: It's Good For Your Health

Cancercompass News: Breast Cancer — Sun, 14 Mar 2010 00:00:00 +0100

Daily physical activity is a prerequisite for good health. Gardening is an excellent way to be physically active while growing healthy vegetables and fruits, as well as beautiful flowers. Active people are less likely than inactive people to be obese or have high blood pressure, type 2 diabetes, osteoporosis, coronary artery disease, stroke, depression, colon cancer and premature death. (Source: Cancercompass News: Breast Cancer)

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Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution

Arquivos de Gastroenterologia — Sat, 13 Mar 2010 14:23:58 +0100

CONCLUSIONS: Carcinoid tumors of the colon are frequently right-sided and may be clinically occult until an advanced stage is reached. Based on the relatively poor survival rates reported, it is recommended that, in addition to standard surgical resection, vigorous surveillance for metastatic disease must be performed, particularly during the first 2 years after surgery. In addition, these patients require evaluation of the entire gastrointestinal tract for evidence of coexisting malignancy, along with an extended period of follow-up, because tumor recurrences after 5 years are not uncommon.CONTEXTO: Carcinóides cólicos, excluindo aqueles que se originam no apêndice cecal, são extremamente raros. Devido a esta raridade, as características e comportamento desta neoplasia permanecem ind...

Identification of native Bacillus thuringiensis strain from South India having specific cytocidal activity against cancer cells

Journal of Applied Microbiology — Sat, 13 Mar 2010 00:00:00 +0100

Conclusions: Our observations imply that B. thuringiensis LDC-391 is different from the already reported parasporin producers, as it is showing variation in the target specificity.Significance and Impact of the Study: Characterizing these proteins can pave the way to alleviate problems associated with neoplastic transformation and cancer progression. (Source: Journal of Applied Microbiology)

Therapy Guidance for Patients with Colorectal Cancer Discussed at NCCN® Annual Conference

National Comprehensive Cancer Network — Sat, 13 Mar 2010 00:00:00 +0100

Highlights of the latest version of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines™) for Colon and Rectal Cancer were presented at the NCCN 15th Annual Conference by Paul F. Engstrom, MD, of Fox Chase Cancer Center. Engstrom discussed specific recommendations for therapies and provided guidance on patients who benefit most from select regimens. March 11, 2010 HOLLYWOOD, FL — Despite statistics stating that colorectal cancer is the fourth most frequen... (Source: National Comprehensive Cancer Network)

Colon Cancer Awareness Month Brings New Resources

About.com Colon Cancer — Sat, 13 Mar 2010 00:00:00 +0100

March is Colorectal Cancer Awareness month. To recognize this important public health event, the American College of Gastroenterology (ACG) has created several terrific resources about colon and rectal cancer: Audio Q & A on Colorectal Cancer Screening, in which ACG experts answer common questions about: Colorectal cancer Colorectal cancer screening options Colonoscopy screening How to prepare for a colon cancer screening test African American risk factors for colorectal cancer And much more Colon Cancer Resource Page with information and tools for patients and doctors. The What to Expect During a Colonoscopy video, where patients can learn about the colonoscopy test. The video follows a patient who undergoes the potentially lifesaving exam. It is documentary-style ...

Biotransformation of L: -Selenomethionine and Selenite in Rat Gut Contents.

Biological Trace Element Research — Sat, 13 Mar 2010 00:00:00 +0100

Authors: Krittaphol W, McDowell A, Thomson CD, Mikov M, Fawcett JP L: -Selenomethionine (SeMet) and sodium selenite are widely used selenium nutritional supplements with potential benefit in preventing cancer. However, supplementation is not without risks of toxicity if intake is too high. The aim of the present study was to investigate SeMet and selenite metabolism in the gastrointestinal tract with particular focus on the formation of the volatile selenium excretion products, dimethylselenide (DMSe) and dimethyldiselenide (DMDSe). Adult male Wistar rats (n = 5) were euthanized, their intestinal tracts removed and the contents of jejunum, ileum, caecum and colon used to prepare 10% suspensions in saline. SeMet and selenite (0.5-0.6 mM) were then incubated with these suspensions at 37 ...

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I Have Colon Polyps: Now What?

Health News from Medical News Today — Fri, 12 Mar 2010 11:00:00 +0100

M. D. Anderson Cancer Center are encouraging men and women to learn more about colon polyps and how they affect a person's risks for cancer. "Finding out you have colon polyps doesn't have to be frightening," said Gottumukkala S. Raju, M.D., professor in the Department of Gastroenterology, Hepatology and Nutrition at M. D. Anderson. "Most colon polyps are not cancer. Yet, certain kinds of polyps may make you more likely to develop colon cancer." The colon is part of the large intestine. A colon polyp is a growth on the inside lining of the colon... (Source: Health News from Medical News Today)

I Have Colon Polyps: Now What?

Public Health News From Medical News Today — Fri, 12 Mar 2010 11:00:00 +0100

M. D. Anderson Cancer Center are encouraging men and women to learn more about colon polyps and how they affect a person's risks for cancer. "Finding out you have colon polyps doesn't have to be frightening," said Gottumukkala S. Raju, M.D., professor in the Department of Gastroenterology, Hepatology and Nutrition at M. D. Anderson. "Most colon polyps are not cancer... (Source: Public Health News From Medical News Today)

Clinicopathological Features of Colon Polyps from African-Americans

Digestive Diseases and Sciences — Fri, 12 Mar 2010 06:50:07 +0100

Conclusion There was a ratio of 8:1 for neoplastic to hyperplastic polyps in our study, which is more than what has been reported in Caucasians (7:1). Our data shows a shift in polyps from the left side to the right side of the colon in recent years. This data is consistent with the lack of a reduction in the incidence of colon cancer in African-Americans. Screening is thus very important in AA to reduce the incidence of colon cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1133-5Authors Mehdi Nouraie, Howard University College of Medicine Department of Medicine and Cancer Center 2041 Georgia Avenue, N.W. Washington DC 20060 USAFatemeh Hosseinkhah, Howard University College of Medicine Department of Medicine and Cancer Center 204...

Short-Term Outcomes of Laparoscopic Colectomy for Transverse Colon Cancer

Journal of Gastrointestinal Surgery — Fri, 12 Mar 2010 06:49:22 +0100

Conclusions Laparoscopic resection for TCC can be performed safely with similar short-term postoperative outcomes seen for colon cancer at other sites. Laparoscopic resection may be associated with faster gastrointestinal recovery and shorter length of hospital stay, compared with open surgery. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-010-1182-2Authors Takashi Akiyoshi, Cancer Institute Hospital Gastroenterological Center, Department of Gastroenterological Surgery 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanHiroya Kuroyanagi, Cancer Institute Hospital Gastroenterological Center, Department of Gastroenterological Surgery 3-10-6 Ariake, Koto-ku Tokyo 135-8550 JapanYoshiya Fujimoto, Cancer Institute Hospital Gastroenterological Center, Dep...

Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo

Molecular Cancer — Fri, 12 Mar 2010 00:00:00 +0100

In this study, we explored the specific role of mTORC2 in colon cancer using a short hairpin RNA expression system to silence the mTORC2-associated protein rictor. We found that downregulation of rictor in HT29 and LS174T colon cancer cells significantly reduced cell proliferation. Knockdown of rictor also resulted in a G1 arrest as observed by cell cycle analysis. We further observed that LS174T cells deficient for rictor failed to form tumors in a nude mice xenograft model. Taken together, these results show that the inhibition of mTORC2 reduces colon cancer cell proliferation in vitro and tumor xenograft formation in vivo. They also suggest that specifically targeting mTORC2 may provide a novel treatment strategy for colorectal cancer. (Source: Molecular Cancer)

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Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms.

Molecular Biology Reports — Fri, 12 Mar 2010 00:00:00 +0100

In this study we show that TNFalpha, but not LPS, was significantly able to stimulate the production of NO in HSV-tk transduced 9L glioblastoma cell lines, mediated by the up-regulation of iNOS transcript and iNOS protein. The TNFalpha-induced up-regulation of iNOS expression was mediated by MAPK and NF-kappaB signaling pathways as revealed by using selective pharmaceutical inhibitors. A culture liquid extract of the edible and medicinal mushroom Marasmius oreades that was previously shown to inhibit iNOS expression in MCF-7 was utilized to prepare fractions and evaluate their ability to affect TNFalpha-induced iNOS expression in HSV tk transduced 9L cell lines. While most of the tested fractions were shown to inhibit TNFalpha-induced iNOS expression, they targeted different signaling path...

Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Biochemical Pharmacology — Fri, 12 Mar 2010 00:00:00 +0100

Authors: Thapa D, Babu D, Park MA, Kwak MK, Lee YR, Kim JM, Kwon TK, Kim JA Nonsteroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) has received greater attention as a novel molecular target for anticancer therapeutics in recent years. We identified a novel synthetic hexahydrocannabinol analog, LYR-8 [(1-((9S)-1-hydroxy-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-2-yl)ethanone)], as a potent NAG-1 and apoptosis inducer in a panel of human cancer cells. LYR-8 did not possess any affinity for cannabinoid receptor CB(1) or CB(2), which eliminates the concern about potential psychoactive side effects. LYR-8 dramatically induced NAG-1 expression and apoptosis in HCT116 (wild-type p53) and HT29 (mutant p53) colon cancer cells. The NAG-1 expression by LYR-8 was n...

Obesity linked to poor colon cancer prognosis

ScienceDaily Headlines — Thu, 11 Mar 2010 17:31:32 +0100

Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a new study. (Source: ScienceDaily Headlines)

Obesity and Colon Cancer a Deadly Combination

Medical Headlines From Ivanhoe.com — Thu, 11 Mar 2010 05:00:00 +0100

(Ivanhoe Newswire) -- Obese patients with colon cancer may have a greater chance of dying from the disease compared to those at a normal weight. (Source: Medical Headlines From Ivanhoe.com)

Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells

Journal of Cancer Research and Clinical Oncology — Thu, 11 Mar 2010 02:40:43 +0100

Conclusion In summary, our results identify both PPARγ and PPARβ/δ as an alternative COX-independent mechanism of VEGF induction in colorectal tumor cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0856-1Authors Clemens Röhrl, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaUlrike Kaindl, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaInga Koneczny, Medical University of Vienna Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research Borschkegasse 8a 1090 Vienna AustriaXenia Hudec, Medical Univer...

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Mayo Researchers Link Obesity To Worse Outcome In Patients Being Treated For Colon Cancer

Health News from Medical News Today — Thu, 11 Mar 2010 01:00:00 +0100

It's long been known that obesity is linked to increased risk of developing colon cancer, but now researchers at the Mayo Clinic campus in Minnesota have found that obesity is associated with worse outcomes in patients who have already been diagnosed and treated for the cancer. The authors found that obesity was significantly associated with a greater number of tumor-containing regional lymph nodes and worse survival rates, independent of other tumor features... (Source: Health News from Medical News Today)

Mayo Researchers Link Obesity To Worse Outcome In Patients Being Treated For Colon Cancer

Cancer / Oncology News From Medical News Today — Thu, 11 Mar 2010 01:00:00 +0100

The antitumor activity of the fungicide ciclopirox

International Journal of Cancer — Thu, 11 Mar 2010 00:00:00 +0100

Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results indicate that CPX inhibited cell proliferation and induced apoptosis in human rhabdomyosarcoma (Rh30), breast carcinoma (MDA-MB231) and colon adenocarcinoma (HT-29) cells in a concentration-dependent manner. By cell cycle analysis, CPX induced accumulation of cells in G1/G0 phase of the cell cycle. Concurrently, CPX downregulated cellular protein expression of cyclins (A, B1, D1 and E) and cyclin-dependent kinases (CDK2 and CDK4) and upregulated expression of the CDK inhibitor...

Expression and Functional Research of TLR4 in Human Colon Carcinoma.

The American Journal of the Medical Sciences — Thu, 11 Mar 2010 00:00:00 +0100

CONCLUSION:: TLR4 is expressed on human colon carcinoma cells and functionally active. It may play important roles in promoting immune escape of human colon carcinoma cells by inducing immunosuppressive factors and apoptosis resistance. PMID: 20228668 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

Regeneration, in vitro glycoalkaloids production and evaluation of bioactivity of callus methanolic extract of Solanum tuberosum L.

Fitoterapia — Thu, 11 Mar 2010 00:00:00 +0100

Authors: Al-Ashaal HA Callus and differentiated shoots initiated from Solanum tuberosum L on MS media contained BA, IAA, and Kin. Glycoalkaloids produced in callus and shoots in concentrations higher than original tubers using HPLC. Callus methanolic extract had promising anticancer activity with low IC(50) values against human carcinoma cell lines of breast, lymphoplastic leukemia, larynx, liver, cervix, colon, and brain, IC(50) (mug/mL) were 2.7, 3.7, 6, 6.7, 10, 13.6, and 22.3 respectively. Antioxidant capacity of the extract (76.4%) performed using ESR. Preliminary screening showed that the extract exhibited in vitro virucidal activity against Herpes simplex. The extract possessed in-vitro schistomicidal and fasciolicidal activity. PMID: 20227470 [PubMed - as supplied by publis...

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Lymphoepithelial pancreatic cyst: an atypical benign pancreatic mass presenting with a "cheerios-like" appearance.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

CONCLUSION: This particular finding could help in the differential diagnosis of this benign lesion from other pancreatic masses. PMID: 20208329 [PubMed - in process] (Source: JOP)

Intraductal Papillary Mucinous Neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

Authors: Bussom S, Saif MW The diagnosis and treatment of intraductal papillary mucinous tumors (IPMN) of the pancreas has evolved over the last decade. IPMN is a disease of the ductal epithelium and represent a spectrum of disease, ranging from benign to malignant lesions, making the early detection and characterization of these lesions important. As with villous adenomas of the colon, not all IPMNs will develop into adenocarcinoma. Definitive management is surgical resection for appropriate candidates, as benign lesions harbor malignant potential. Growing controversy revolves around issues of natural history, management of small-branch-duct lesions, ability to predict malignancy and/or progression, and surveillance strategies. Given these controversies, novel methods are needed to he...

AZ Researchers Get $1.5M to Study Vitamin D Effect on Cancer

Health — Wed, 10 Mar 2010 18:52:31 +0100

A $1.5 million grant will enable researchers at the Arizona Cancer Center to study the relationship between vitamin D and colon cancer. (Source: Health)

Thyroid cancer is the most common cancer associated with acromegaly

Pituitary — Wed, 10 Mar 2010 18:28:48 +0100

Abstract The aim of the study was to screen the malignancy in an acromegalic patient group and to determine whether there was any increased risk and the incidence of malignancy and its association with disease characteristics such as duration of disease, latency in diagnosis, and GH and IGF-1 levels. One hundred-five (65 female, 40 male) patients with acromegaly followed and treated at Cerrahpasa Medical School, Endocrinology and Metabolism outpatient clinic between 1983 and 2007 were included in this study. The patients were screened with colonoscopy, mammography, and thyroid and prostate ultrasonography (US). Malignancy was detected in 16 (15%) patients. Thyroid cancer was found in 5 patients (4.7%), breast cancer in 3 (2.8%), colon cancer in 2 (1.9%), lung cancer in 2 (...

Current Status of Chromoendoscopy and Narrow Band Imaging in Colonoscopy

Clinics in Colon and Rectal Surgery — Wed, 10 Mar 2010 17:13:26 +0100

Clinics in Colon and Rectal Surgery 2010; 23: 021-030DOI: 10.1055/s-0030-1247853ABSTRACTColonoscopy, the preferred procedure for colon cancer screening, has well-documented limitations. To improve colonoscopy's effectiveness, augmented endoscopy techniques, such as chromoendoscopy and narrow band imaging (NBI) have been evaluated. Both techniques are inexpensive, safe, and relatively easy to perform. Chromoendoscopy has an increasingly important role in surveillance of IBD, but significant work is needed to determine the optimal staining techniques and mucosal surface pattern analysis before this technique can be incorporated into routine clinical practice. NBI is a much newer technology with far less data. Well-designed prospective randomized controlled trials have failed to identify a be...

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Laparoscopy for Colon and Rectal Cancer

Clinics in Colon and Rectal Surgery — Wed, 10 Mar 2010 17:13:26 +0100

Clinics in Colon and Rectal Surgery 2010; 23: 051-058DOI: 10.1055/s-0030-1247856ABSTRACTLaparoscopy has emerged as a useful tool in the surgical treatment of diseases of the colon and rectum. Specifically, in the application of colon cancer, a laparoscopic-assisted approach offers short-term benefits to patients while maintaining a long-term oncologic outcome. Hand-assisted laparoscopic surgery may help decrease operative times while preserving the benefits of laparoscopy. The literature on the use of laparoscopy for rectal cancer is still in its early stages. Limited data suggest short-term benefits without compromising oncologic outcome; however, data from large multicenter trials will clarify the role of laparoscopy in the treatment of rectal cancer. Robotic proctectomy is a novel techn...

Renal tubular acidosis secondary to capecitabine, oxaliplatin, and cetuximab treatment in a patient with metastatic colon carcinoma: a case report and review of the literature

International Journal of Clinical Oncology — Wed, 10 Mar 2010 16:13:28 +0100

We report a case of renal tubular acidosis (RTA) secondary to capecitabine, oxaliplatin, and cetuximab administration in a 63-year-old woman with liver metastasis from colon carcinoma who had partial treatment response. On day 5 posttreatment, she arrived to the emergency room with severe weakness, and blood tests demonstrated hypokalemia with metabolic acidosis. Urine potassium levels were elevated, and the transtubular potassium gradient (TTKG) was 6.6, consistent with hypokalemic RTA with associated Fanconi syndrome, which presented as hyperphosphaturia, uricaciduria, and loss of protein and sugar in the urine. She was treated with intravenously administered potassium and fluids. RTA is one type of nephrotoxicity induced by chemotherapy, and it is reversible in mild cases when app...

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells

Journal of Cancer Research and Clinical Oncology — Wed, 10 Mar 2010 16:10:23 +0100

Conclusions These results suggest that hypoxia induce the expression of HIF-1α and MDR1/P-gp in colon carcinoma and HIF-1α expression may be associated with the gene MDR1 (P-gp) and interactively involved in the occurrence of tumor multidrug resistance. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0828-5Authors Zhenyu Ding, Third Military Medical University Department of Oncology, Southwest Hospital 30 Gaotanyan Street, Shapingba District Chongqing 400038 ChinaLi Yang, Third Military Medical University Department of Oncology, Southwest Hospital 30 Gaotanyan Street, Shapingba District Chongqing 400038 ChinaXiaodong Xie, General Hospital of Shenyang Military Region Department of Oncology Shenyang 110840 Liaoning ChinaFangwei Xie, Third Mi...

PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of colorectal cancer cells

Journal of Cancer Research and Clinical Oncology — Wed, 10 Mar 2010 16:10:15 +0100

Conclusion Our results demonstrate that PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of HCT-116 colorectal cancer cells, which could constitute a potential therapeutic target for treatment of this cancer type. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0836-5Authors Wallace Martins de Araújo, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia Celular Rua André Cavalcanti 37, 5° andar 20230-051 Rio de Janeiro RJ BrazilFlavia Castello Branco Vidal, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia Celular Rua André Cavalcanti 37, 5° andar 20230-051 Rio de Janeiro RJ BrazilWaldemir Fernandes de Souza, Instituto Nacional de Câncer, Rio de Janeiro Divisão de Biologia ...

Virus 'kills prostate cancer'

NHS News Feed — Wed, 10 Mar 2010 15:47:00 +0100

Conclusion This is early research on a new treatment for prostate cancer. It is worth noting that: The virus has already been tested, and shown some success, in treatment for other cancers. This means that the route to clinical use may be shorter for this treatment indication but it will not get around the fact that many more patients will need to be tested in rigorous trials to see if the treatment is better than current alternatives. The treatment seemed to have very few side effects, which is a positive sign for a cancer treatment. The researchers acknowledge that it is unfortunate that the reovirus did not seem to infect non-cancerous tissue after the injection as this means that it is unlikely that the virus could spread to other areas of the prostate cancer and kill these, i...

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Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study

International Journal of Colorectal Disease — Wed, 10 Mar 2010 15:33:45 +0100

Conclusion Multiple serrated polyps were associated with an increased personal risk of CRC. A subset of patients with the highest polyp numbers was more likely to be male and to have no family history of CRC. This result suggests heterogeneous modes of inheritance and has implications for studies investigating the genetic basis of multiple serrated polyps. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0907-8Authors Daniel D. Buchanan, QIMR Familial Cancer Laboratory Herston, Brisbane Q 4006 AustraliaKevin Sweet, Ohio State University Division of Human Genetics Columbus OH 43221 USAMusa Drini, The Royal Melbourne Hospital Department of Colorectal Medicine and Genetics Parkville, Melbourne VIC 3050 AustraliaMark A. Jenkins, University of ...

Obesity and Colon Cancer

MedlinePlus Health News — Wed, 10 Mar 2010 15:11:57 +0100

Source: HealthDay - Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News)

Inside Colonoscopy Screenings

Health News: CBSNews.com — Wed, 10 Mar 2010 13:37:34 +0100

Dr. Mark Pochapin Explains How Doctors Perform This Important Test for Colon Cancer (Source: Health News: CBSNews.com)

Link Between Obesity And Poor Colon Cancer Prognosis

Health News from Medical News Today — Wed, 10 Mar 2010 12:00:00 +0100

Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Obesity has long been established as a risk factor for cancer, but our study in colon cancer patients shows that obesity predicts a poorer prognosis after the cancer is surgically removed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic in Rochester... (Source: Health News from Medical News Today)

Link Between Obesity And Poor Colon Cancer Prognosis

Obesity / Weight Loss / Fitness News From Medical News Today — Wed, 10 Mar 2010 12:00:00 +0100

Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research... (Source: Obesity / Weight Loss / Fitness News From Medical News Today)

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Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer

Health News from Medical News Today — Wed, 10 Mar 2010 09:00:00 +0100

Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D., professor of Internal Medicine at the University of Michigan Medical School. "They think the symptoms represent something more sinister... (Source: Health News from Medical News Today)

Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer

GastroIntestinal News From Medical News Today — Wed, 10 Mar 2010 09:00:00 +0100

Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D... (Source: GastroIntestinal News From Medical News Today)

Obese Colon Cancer Survivors Face Poorer Prognosis

MedicineNet Cancer General — Wed, 10 Mar 2010 07:00:00 +0100

Title: Obese Colon Cancer Survivors Face Poorer PrognosisCategory: Health NewsCreated: 3/9/2010 2:10:00 PMLast Editorial Review: 3/10/2010 (Source: MedicineNet Cancer General)

Obese Colon Cancer Survivors Face Poorer Prognosis

MedicineNet Diabetes General — Wed, 10 Mar 2010 07:00:00 +0100

Title: Obese Colon Cancer Survivors Face Poorer PrognosisCategory: Health NewsCreated: 3/9/2010 2:10:00 PMLast Editorial Review: 3/10/2010 (Source: MedicineNet Diabetes General)

Overexpression of translocator protein in inflammatory bowel disease: Potential diagnostic and treatment value

Inflammatory Bowel Diseases — Wed, 10 Mar 2010 00:00:00 +0100

Inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn's disease, are chronic inflammatory disorders that increase the risk for colorectal cancer. The mitochondrial translocator protein (TSPO) is a high-affinity drug- and cholesterol-binding protein expressed in the colon and its expression is increased in colon cancers. The aim of this study was to investigate TSPO expression in IBD biopsies and to establish an animal model of IBD to examine the role of TSPO. In addition, we evaluated the potential use of TSPO drug ligands in diagnosing and treating IBD.TSPO expression in IBD biopsies was evaluated using immunohistochemistry. IBD was induced in a rat experimental model via treatment with dextran sodium sulfate (DSS). Colon morphology, TSPO expression, and proinflammatory...

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Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer

Drugs.com - Clinical Trials — Tue, 09 Mar 2010 19:11:28 +0100

Researchers say that obesity leads to more aggressive colon cancer and that the risk differs between men and women ROCHESTER, Minn.--(BUSINESS WIRE)--Mar 9, 2010 - It's long been known that obesity is linked to increased risk of developing... (Source: Drugs.com - Clinical Trials)

Obese Colon Cancer Survivors Face Poorer Prognosis

MedlinePlus Health News — Tue, 09 Mar 2010 19:00:00 +0100

Study found chances of recurrence, death higher than among normal-weight patients Source: HealthDay Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News)

Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer

News from Mayo Clinic — Tue, 09 Mar 2010 18:44:16 +0100

Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: News from Mayo Clinic)

Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer

Mayo Clinic Research News — Tue, 09 Mar 2010 18:44:16 +0100

Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Research News)

Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer

Mayo Clinic Rochester News — Tue, 09 Mar 2010 18:44:16 +0100

Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Rochester News)

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The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases

Journal of Biomedicine and Biotechnology — Tue, 09 Mar 2010 17:06:44 +0100

In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects. (Source: Journal of Biomedicine and Biotechnology)

Video: Peter Yarrow on Colon Health

Health News: CBSNews.com — Tue, 09 Mar 2010 14:49:37 +0100

Singer Peter Yarrow spoke with Harry Smith about the death of Mary Travers and his campaign for colon cancer prevention. (Source: Health News: CBSNews.com)

'Giant colon' promotes colorectal cancer screening

CTV Health — Tue, 09 Mar 2010 13:56:15 +0100

The Colorectal Cancer Association of Canada, in conjunction with government partners, has been taking a "giant colon" on the road to cities across Ontario to educate people about the disease and to promote the need for screening. (Source: CTV Health)

Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer

Medscape Today Headlines — Tue, 09 Mar 2010 12:04:24 +0100

Does hormone replacement therapy in menopausal women decrease the risk of invasive colon cancer? American Journal of Epidemiology (Source: Medscape Today Headlines)

Obesity linked to poor colon cancer prognosis

EurekAlert! - Social and Behavioral Science — Tue, 09 Mar 2010 05:00:00 +0100

(American Association for Cancer Research) Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Social and Behavioral Science)

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Patients with Irritable Bowel Syndrome not more likely to develop polyps, colon cancer

EurekAlert! - Medicine and Health — Tue, 09 Mar 2010 05:00:00 +0100

(University of Michigan Health System) Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies. (Source: EurekAlert! - Medicine and Health)

Metastasis of colon cancer to the thyroid gland: A case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach

Diagnostic Cytopathology — Tue, 09 Mar 2010 00:00:00 +0100

Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms. However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging. In particular, metastasis of colon cancer to the thyroid gland is very rare. In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated. FNA cytology showed necrosis and atypical tall columnar cells; since, the patient at age 60 had undergone surgery for a sigmoid-rectal cancer metastasizing to the liver and subsequently to the lung, a suspicion of metastasis from colon cancer was raised. This was corroborated by cell-block immunocytochemistry showing a cytokeratin (CK) 7 negative/CK20-positive staining pattern; thyreoglobulin and TTF-1 ...

Wall effects in continuous microfluidic magneto-affinity cell separation

Biotechnology and Bioengineering — Tue, 09 Mar 2010 00:00:00 +0100

We present a theoretical and experimental study that provides a quantitative description of hydrodynamic wall interactions and wall rolling velocity of cells. A transient convection model describes the transport of cells in two-phase microfluidic flow under the influence of an external magnetic field. Transport of cells along the microchannel walls is also considered via an additional equation. Results show the variation of cell flux in the fluid phases and the wall as a function of a dimensionless parameter arising in the equations. Our results suggest that conditions may be optimized to maximize cell separation while minimizing contact with the wall surfaces. Experimentally measured cell rolling velocities on the wall indicate the presence of other near-wall forces in addition to fluid s...

Obesity Linked to Higher Mortality Rate in Colon Cancer

Modern Medicine — Tue, 09 Mar 2010 00:00:00 +0100

In patients with colon cancer, obesity was associated with higher rates of cancer recurrence and mortality, according to research published online March 9 in Clinical Cancer Research. (Source: Modern Medicine)

Obesity Is an Independent Prognostic Variable in Colon Cancer Survivors.

Clinical Cancer Research — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: Obesity is an independent prognostic variable in colon cancer survivors and shows gender-related differences. These data suggest that obesity-related biological factors can influence clinical outcome. Clin Cancer Res; 16(6); 1884-93. PMID: 20215553 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer.

Clinical Cancer Research — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: CDDO-Me abrogated the immune suppressive effect of MDSCs and improved immune responses in tumor-bearing mice and cancer patients. It may represent an attractive therapeutic option by enhancing the effect of cancer immunotherapy. Clin Cancer Res; 16(6); 1812-23. PMID: 20215551 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Lynch Syndrome-Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry.

Clinical Cancer Research — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: MMR deficiency was identified in 51% of breast cancers arising in known mutation carriers. Breast cancer therefore may represent a valid tissue option for the detection of MMR deficiency in which spectrum tumors are lacking. Clin Cancer Res; 16(7); OF1-11. PMID: 20215533 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Optimized St. John's Wort (Hypericum perforatum L.) Germplasm Lines Exert Cytotoxicity in HT-29 Colon Cancer Cells via Downregulation of NF-κB

Journal of Complementary and Integrative Medicine — Mon, 08 Mar 2010 20:55:35 +0100

Extracts of two germplasm lines of St. John's wort (SJW; Hypericum perforatum L.) selected for enhanced hypericin and hyperforin content were evaluated for potential activity against colon cancer. Bioactivity was assessed in signaling pathways of tumor necrosis factor-a (TNF-α) and nuclear transcription factor-κB (NF-κB) in HT-29 colon cancer cells. Both extracts and the hypericin standard significantly inhibited growth of HT-29 cells. Levels of active NF-κB were reduced in cells treated with either of the plant extracts or hypericin, but the purified hyperforin standard was comparatively ineffective. The combination of TNF-α and SJW treatments had significantly higher cytotoxic effects, and reduced the expression of NF-κB, inhibitor of NF-κBs (IκBa), IκB kinase b (IKKb), and TNF ...

Positron Emission Tomography-Computed Tomography in Paraneoplastic Neurologic Disorders: Systematic Analysis and Review [Original Contribution]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusion In a paraneoplastic neurologic context, PET-CT improves the detection of cancers when other screening test results are negative, particularly in the setting of seropositivity for a neuronal nuclear or cytoplasmic autoantibody marker of cancer. Published online January 11, 2010 (doi:10.1001/archneurol.2009.336). (Source: Archives of Neurology)

Chemotherapy-Associated Peripheral Sensory Neuropathy Assessed Using In Vivo Corneal Confocal Microscopy [Images in Neurology]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

(Source: Archives of Neurology)

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Screening and Identification of Recombinant Anti-Idiotype Antibodies against Gastric Cancer and Colon Cancer Monoclonal Antibodies by a Phage-Displayed Single-Chain Variable Fragment Library

Journal of Biomolecular Screening — Mon, 08 Mar 2010 17:34:28 +0100

Several monoclonal antibodies (McAbs) have been developed that show high sensitivity and specificity to gastric cancer and colorectal cancer. However, few of the antigens recognized by these antibodies have been identified. The authors now report the selection of anti-idiotype (anti-id) antibodies of MGb1 McAb against gastric cancer and MC5 McAb against colorectal cancer using phage-displayed single-chain variable fragment (ScFv) libraries. After purification, the anti-id antibodies were approximately 30 kd and could be recognized by MGb1/MC5 McAb. Anti-id antibodies significantly blocked the binding of MGb1 and MC5 to gastric cancer/colorectal cancer cells, respectively, suggesting that the antibodies were specific to MGb1 and MC5. Antibodies against gastric and colorectal cancer could be...

Proteins May Predict Spread of Colon Cancer

MedlinePlus Health News — Mon, 08 Mar 2010 17:00:00 +0100

Discovery could lead to blood test that would aid prevention efforts, scientist says Source: HealthDay Related MedlinePlus Page: Colorectal Cancer (Source: MedlinePlus Health News)

Funny Name, Serious Goals for Colon Cancer Awareness

About.com Colon Cancer — Mon, 08 Mar 2010 11:57:51 +0100

March is Colon Cancer Awareness month. Raising awareness of this disease is so vitally important. Colon cancer is one of the most preventable cancers, yet nearly 50,000 Americans lose their lives to colon cancer every year in the United States. It is the second leading cause of cancer deaths in the US. The Undy 5000 The Colon Cancer Alliance (CCA) is doing their part to raise awareness and funds to fight colon cancer. CCA has created a series of running races called The Undy 5000. In a funny play on words, each race is referred to as "a brief run to fight colon cancer." Each race is 5 kilometers (3.1 miles) in length, which is 5000 meters. Cancer-specific races, walks, and other events are a successful and valuable way to raise awareness and funds to fight cancer. The Undy 5000 colon cance...

Elderly patients aggressively over-treated with pharmaceuticals

NaturalNews.com — Mon, 08 Mar 2010 07:00:00 +0100

(NaturalNews) Researchers from the Cochrane Collaboration research group have determined that seniors over the age of 80 are being given too many drugs and in too high of doses. Particularly with high blood pressure, doctors are too aggressively treating the elderly with pharmaceuticals which is doing them more harm than good.According to the U.S. Centers for Disease Control and Prevention (CDC), nearly a quarter of all Americans between 20 and 75 have hypertension while roughly 70 percent of those over 75 have it.The conventional approach to treating high blood pressure is to prescribe a variety of drugs that, together, doctors hope will achieve a target of 140/90 mmHg. However after scouring several studies to see if such treatments are actually working, Dr. James Wright, head of Cochran...

Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility

Oncogene — Mon, 08 Mar 2010 00:00:00 +0100

Authors: D Krndija, H Schmid, J-L Eismann, U Lother, G Adler, F Oswald, T Seufferlein & G von Wichert (Source: Oncogene)

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Prevent Cancer Foundation Promotes Colon Cancer Awareness Month

About.com Colon Cancer — Mon, 08 Mar 2010 00:00:00 +0100

In honor of March being Colon Cancer Awareness Month, the Prevent Cancer Foundation is kicking off a tour of their Cancer Super Colon educational program. This innovative program uses a large model of the colon to raise awareness of colon cancer and educate people about colon health. People can literally "tour the colon", by walking through the life-size, medically accurate colon model. Nearly two dozen Super Colon educational events are taking place throughout the US from now through October 2010. The tour is showing up all across the country, from California, to South Dakota, Texas, Florida, Michigan, and places in between. Visit the Prevent Cancer Foundation Super Colon Website to find an event near you and for more information. Prevent Cancer Foundation Promotes Colon Cancer Awareness ...

Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon.

The British Journal of Nutrition — Mon, 08 Mar 2010 00:00:00 +0100

In conclusion, ageing and chronic alcohol consumption alter genomic DNA methylation, p16 promoter methylation and p16 gene expression in the mouse colon, and dietary folate availability can further modify the relationship with alcohol in the young mouse. PMID: 20205967 [PubMed - as supplied by publisher] (Source: The British Journal of Nutrition)

For Best Colon Cancer Screening, Know Your Options

About.com Colon Cancer — Mon, 08 Mar 2010 00:00:00 +0100

Colon cancer screening options run the gamut in terms of accuracy, scientific evidence for effectiveness, amount of the colon examined, the need for sedation, and more. New research shows that having a full understanding of all of the aspects of each type of colon cancer screening method can help people better determine which test meets their needs. Which Tests, Which Outcomes Researchers wanted to find out how people felt about different colon cancer screening methods before and after being educated about thirteen aspects of each test. The colon cancer screening methods studied were: Fecal occult blood testing Flexible sigmoidoscopy Colonoscopy Double-contrast barium enema The aspects of each test that study participants learned about were: Accuracy: How well does the...

Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.

World Journal of Gastroenterology : WJG — Sun, 07 Mar 2010 00:00:00 +0100

Authors: Guiu B, Vincent J, Guiu S, Ladoire S, Ortega-Deballon P, Cercueil JP, Chauffert B, Ghiringhelli F Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper...

Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases

BMC Cancer — Sun, 07 Mar 2010 00:00:00 +0100

Conclusions: This study describes cellular and macromolecular changes contributing to immunological escape mechanisms during metastatic growth in a colorectal liver metastases mouse model simulating the situation in human cancer. (Source: BMC Cancer)

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Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines

Journal of Experimental and Clinical Cancer Research — Sun, 07 Mar 2010 00:00:00 +0100

Conclusion: This is the first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines. The involvement of ROS and caspase activation was highly variable among the five cell lines, although all were susceptible to TRD induced cell death. Our results indicate, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity. (Source: Journal of Experimental and Clinical Cancer Research)

Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53.

Cancer Biology and Therapy — Sat, 06 Mar 2010 19:28:05 +0100

Authors: Carney BK, Cassimeris L Stathmin, a microtubule regulatory protein, is overexpressed in many cancers and required for survival of several cancer lines. In a study of breast cancer cell lines, Alli et al. (Oncogene. 26:1003-12) proposed that stathmin is required for survival of cells lacking p53, but this hypothesis was not tested directly. Here we tested their hypothesis by examining cell survival in cells depleted of stathmin, p53 or both proteins. Comparing HCT116 colon cancer cell lines differing in TP53 genotype, stathmin depletion resulted in significant death only in cells lacking p53. As a second experimental system, we compared the effects of stathmin depletion from HeLa cells, which normally lack detectable levels of p53 due to expression of the HPV E6 protein. Stathm...

Selective Suicide Gene Therapy of Colon Cancer Exploiting the Urokinase Plasminogen Activator Receptor Promoter

BioDrugs — Sat, 06 Mar 2010 14:07:50 +0100

(Source: BioDrugs)

Researchers find oncogene is important in pancreatic cancer growth and spread

ScienceDaily Headlines — Sat, 06 Mar 2010 10:00:00 +0100

Researchers have found that PKC-iota (PKC-i), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. They also found that genetically inhibiting PKC-i in laboratory animals led to a significant decrease in pancreatic tumor growth and spread. (Source: ScienceDaily Headlines)

Foxp3 Expression in p53-dependent DNA Damage Responses [Signal Transduction]

Journal of Biological Chemistry — Fri, 05 Mar 2010 14:37:12 +0100

The forkhead transcription factor, Foxp3, is thought to act as a master regulator that controls (suppresses) expression of the breast cancer oncogenes, SKP2 and HER-2/ErbB2. However, the mechanisms that regulate Foxp3 expression and thereby modulate tumor development remain largely unexplored. Here, we demonstrate that Foxp3 up-regulation requires p53 function, showing that Foxp3 expression is directly regulated by p53 upon DNA damage responses in human breast and colon carcinoma cells. Treatment with the genotoxic agents, doxorubicin or etoposide, induced Foxp3 expression in p53-positive carcinoma cells, but not in cells lacking p53 function. Furthermore, knock down of endogenous wild-type p53 using RNA interference abrogated Foxp3 induction by genotoxic agents, and exogenous expression o...

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Contrasting US and European approaches to colorectal cancer screening: which is best?

Gut — Fri, 05 Mar 2010 11:12:52 +0100

In the recent 1–2 decades, we have seen a considerable development in colorectal cancer (CRC) screening modalities and programme implementation, but major challenges remain. While CRC is still the second leading cause of cancer death in both the USA and Europe, there are limited data on the efficacy and effectiveness of all screening modalities except for the faecal occult blood test (FOBT). Newer screening tests, such as faecal immunochemical tests, molecular markers and CT colonography are being introduced and variably adopted, though overall rates of screening are suboptimal. Professional societies and governmental bodies have endorsed screening, though recommended approaches are quite variable, which may help to explain the great variation in screening practices. Unfortunately, q...

Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer

Gut — Fri, 05 Mar 2010 11:12:51 +0100

Conclusion This study provides the first evidence that high VFA independently predicts a poorer outcome in patients given first-line bevacizumab-based treatment for MCC. However, this predictive biomarker needs to be validated in a different dataset. (Source: Gut)

CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver

Gut — Fri, 05 Mar 2010 11:12:51 +0100

Conclusion CD10 expression in CRC cells abrogates the anti-tumour effect of hepatic MENK by degrading it, which enhances liver metastasis of CD10-positive CRC cells. (Source: Gut)

Blood Test May Predict Colon Cancer Spread

MedicineNet Cancer General — Fri, 05 Mar 2010 07:00:00 +0100

Title: Blood Test May Predict Colon Cancer SpreadCategory: Health NewsCreated: 3/5/2010 10:50:00 AMLast Editorial Review: 3/5/2010 10:50:46 AM (Source: MedicineNet Cancer General)