MedWorm: Dysgerminoma

Pure dysgerminoma of the ovary 35 years on: A single institutional experience.

Gynecologic Oncology — Fri, 22 Jan 2010 00:00:00 +0100

CONCLUSION: The long-term outcome of patients with pure ovarian dysgerminoma is excellent. Recurrences occur within 2 years of diagnosis and are treatable. Patients can be treated with fertility-sparing surgery and can expect good reproductive outcomes. PMID: 20097412 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance

Journal of Pediatric Surgery — Thu, 31 Dec 2009 15:18:28 +0100

Conclusion: By combining our series with 13 in the literature, a 1.8% malignancy rate occurred in 707 patients with ovarian torsion, markedly less than the reported malignancy rate of 10% in children with ovarian masses. Thus, neither a pathologic nor malignant lead point should be assumed in cases of torsion. In our series, which represents the largest series of torsion in the pediatric literature, all malignancies presented as stage I. These data further support the implementation of operative detorsion and close postoperative ovarian surveillance, with reoperation for persistent masses. Further study is needed to determine if delaying resection by weeks in those cases of persistent masses would result in tumor progression and thus change prognosis. (Source: Journal of Pediatric Surgery)

The histology and management of ovarian cysts found in children and adolescents presenting to a children's hospital from 1991 to 2007: a call for more paediatric gynaecologists.

BJOG : An International Journal of Obstetrics and Gynaecology — Sat, 19 Dec 2009 01:38:37 +0100

Conclusions We recommend the greater use of imaging of the pelvis and tumour markers preoperatively. There should be greater use of conservative expectant management or ovarian-sparing surgery in view of the low risk of malignancy in this age group. The practice of removing ovaries for benign cysts may be overcome by appointing more gynaecologists with advanced training skills training in paediatric and adolescent gynaecology. PMID: 20002396 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Nodular lung schistosomiais lesions after chemotherapy for dysgerminoma.

The American Journal of Tropical Medicine and Hygiene — Sat, 29 Aug 2009 07:43:04 +0100

We report an unusual case of pulmonary schistosomiasis in a traveler to Mali that was diagnosed 16 months after primary infection, one month after she finished chemotherapy for a malignant tumor. Serologic analysis showed marked eosinophilia. Our case emphasizes the need to detect parasitic infections in cancer patients with unexplained eosinophilia, particularly in immigrants and travelers to tropical countries. PMID: 19706907 [PubMed - in process] (Source: The American Journal of Tropical Medicine and Hygiene)

Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS9 mutation: A 46 XY phenotypic female with Frasier syndrome

Pediatric Blood and Cancer — Mon, 03 Aug 2009 23:00:00 +0100

We present the clinical, radiological, and genetic (WT1 mutation analysis) of a 46 XY phenotypic female with Frasier syndrome with bilateral gonadoblastoma with dysgerminoma who developed pilocytic astrocytoma. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)

The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma

Molecular Cancer — Wed, 29 Jul 2009 23:00:00 +0100

Conclusion: A role for TRC8 in dysgerminoma may relate to its interaction with Translin. We propose a model in which one copy of TRC8 is disrupted by a palindrome-mediated translocation followed by complete loss of expression through suppression, possibly mediated by miRNA. (Source: Molecular Cancer)

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Commentary to “Precocious puberty in a 7-year-old boy: A novel case”

Journal of Pediatric Urology — Tue, 30 Jun 2009 23:00:00 +0100

The authors present an unusual case of precocious puberty secondary to an unclassified type of mixed germ cell tumor. The tumor differs from a ‘classic’ MGST in that only the germ cells have a high proliferative index. More importantly, the tumor differs from classic forms in that it is the apparent cause of virilization. To date, there are no reported cases of MGST and virilization in the absence of Leydig cell hyperplasia. The authors clearly state that Leydig cell hyperplasia was absent; however they give no explanation for the elevation in testosterone. Possible clues to this problem can be found in women with gonadoblastoma/dysgerminomas, where elevation of sex steroid is seen in the absence of theca or Leydig cell elements. Interestingly, the germ cell elements in the present cas...

SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors

Cancer — Mon, 13 Apr 2009 04:00:00 +0100

The correct diagnosis of metastatic germ cell tumors is critical, because these tumors can be effectively treated and are even cured with modern therapy. Their histopathologic diagnosis can be challenging without immunohistochemical markers, which currently have limitations. SALL4 is a novel stem cell marker essential to maintain pluripotency and self-renewal of embryonic stem cells. In the current study, the authors investigated the utility of SALL4 as a potential diagnostic marker for metastatic germ cell tumors.Ninety metastatic germ cell tumors from testis, ovary, and extragonadal sites were stained with a monoclonal SALL4 antibody. In addition, 170 metastatic nongerm cell malignancies, including 158 carcinomas (6 head and neck, 8 thyroid, 12 lung, 8 breast, 7 hepatocellular, 3 cholang...

Treatment of clitoromegaly of culturally diverse patients

Journal of Pediatric Urology — Mon, 23 Mar 2009 00:00:00 +0100

Conclusions: Regardless of cultural background patients are affected by clitoromegaly. This is demonstrated in these cases by the reported feelings of discomfort, distress, and sexual inactivity due to embarrassment. The long-term significance of clitoromegaly and the value of clitoroplasty for young patients with disorders of sexual differentiation remain controversial. (Source: Journal of Pediatric Urology)

Surgical resection of a dysgerminoma in a mare.

Australian Veterinary Journal — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Harland S, Smith C, Mogg T, Horadagoda N, Dart A A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal with no history of health problems. Ultrasonographic examination of the mass confirmed its presence, but the origin of the mass could not be accurately determined. Routine haematology and serum biochemistry results were within normal limits. The mare was initially treated conservatively with antibiotics, but the mass continued to increase in size, so it was surgically excised. The mass involved the left ovary. The mare showed transient abdominal pain after surgery, but developed no other complications and was in foal 7 months later. On histology, the mass was dia...

The microenvironment of germ cell tumors harbors a prominent antigen-driven humoral response.

Journal of Immunology — Tue, 24 Feb 2009 18:36:02 +0100

Authors: Willis SN, Mallozzi SS, Rodig SJ, Cronk KM, McArdel SL, Caron T, Pinkus GS, Lovato L, Shampain KL, Anderson DE, Anderson RC, Bruce JN, O'Connor KC Germ cell tumors are a heterogeneous group of neoplasms derived from residual primordial tissue. These tumors are commonly found in the brain, testes, or ovaries, where they are termed germinomas, seminomas, or dysgerminomas, respectively. Like several other tumor types, germ cell tumors often harbor an immune cell infiltrate that can include substantial numbers of B cells. Yet little is known about whether the humoral immune response affects germ cell tumor biology. To gain a deeper understanding of the role B cells play in this tumor family, we characterized the immune cell infiltrate of all three germ cell tumor subtypes and defi...

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A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminoma

Journal of Pediatric Surgery — Sun, 01 Feb 2009 05:00:00 +0100

Abstract: An 8-year-old phenotypic female with campomelic dysplasia (CD) and 46,XY sex-reversal presented with renal colic. Medullary nephrocalcinosis, urolithiasis, and renal malrotation were diagnosed by computed tomographic scanning. Pelvic sonogram identified an enlarged left gonad. Genetic testing revealed a novel SOX9 heterozygous deletion of a cytosine at nucleotide 972 (972delC), causing a frameshift at codon 200, introducing a stop codon 18 codons further downstream (P200fsX218). At laparoscopic gonadectomy, a left dysgerminoma was removed. This first reported case of dysgerminoma in a sex-reversed patient with CD who also had urolithiasis stresses the importance of prophylactic gonadectomy and urologic evaluations in this susceptible population. (Source: Journal of Pediatric Surg...

CT characteristics of ovarian dysgerminoma

The Chinese-German Journal of Clinical Oncology — Wed, 10 Dec 2008 07:48:22 +0100

Conclusion Ovarian dysgerminoma has its CT characteristics. Associated with clinic data, CT is helpful in the diagnosis and differential diagnosis of ovarian dysgerminoma. Content Type Journal ArticleDOI 10.1007/s10330-008-0134-8Authors Xiaoping Yu, Hunan Provincial Tumor Hospital Department of Diagnostic Radiology Changsha 410013 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1610-1979 Journal Volume Volume 7 Journal Issue Volume 7, Number 12 / December, 2008 (Source: The Chinese-German Journal of Clinical Oncology)

Pulmonary cysts in early childhood and the risk of malignancy

Pediatric Pulmonology — Sun, 07 Dec 2008 05:00:00 +0100

Surgery for congenital and early childhood lung cysts is often dictated by symptoms such as respiratory distress, infection or pneumothorax. Asymptomatic cysts present a therapeutic dilemma: surgical intervention and "conservative" observation have advocates. The risk of malignancy in such cysts is considered by some an indication for surgical intervention and is reviewed in this paper. Pleuropulmonary blastoma (PPB) is the most frequent malignancy associated with childhood lung cysts. Although rare, PPB occurs predictably in certain clinical and familial situations. This unique biology of PPB can inform the cyst management decision. The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cy...

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

Reproduction in Domestic Animals — Tue, 04 Nov 2008 00:00:00 +0100

An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-[alpha] and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma. (Source: Reproduction in Domestic Animals)

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch.

Reproduction in Domestic Animals — Mon, 03 Nov 2008 05:00:00 +0100

Authors: Park JK, Goo MJ, Hong IH, Ki MR, Han JY, Jeong KS Contents An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-alpha and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma. PMID: 18992107 [PubMed - as supplied by publisher] (Source: Reproduction in Domestic Animals)

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Management and outcomes of ovarian masses in children and adolescents.

The American Surgeon — Sat, 01 Nov 2008 04:00:00 +0100

Authors: Islam S, Yamout SZ, Gosche JR Ovarian masses in the pediatric age group are rare, and malignancies are even less common. We reviewed our large single-center experience to determine the rate of malignancy and discuss management. We retrospectively reviewed the cases of ovarian masses in children in our institution over a 10-year period. Demographic and tumor-specific data were reviewed and analyzed, and a Student's unpaired t test was used where appropriate. A total of 49 children and adolescents with ovarian masses were found. The mean age at presentation was 13.3 years. Eight masses were malignant (16%) with malignant teratoma, dysgerminoma, and germ cell tumors found. These patients responded to chemotherapy, but there were three recurrences noted that responded to further t...

[Cerebral venous thrombosis in a chemotherapy patient with dysgerminoma.]

Anales de Pediatria — Sat, 01 Nov 2008 04:00:00 +0100

Authors: Latorre González G, López de Silanes de Miguel C, Escribano Gascón AB PMID: 19128751 [PubMed - in process] (Source: Anales de Pediatria)

First Report of Ovarian Dysgerminoma in Cowden Syndrome with Germline PTEN Mutation and PTEN-related 10q Loss of Tumor Heterozygosity.

The American Journal of Surgical Pathology — Sat, 26 Jul 2008 08:54:14 +0100

Page: 1258DOI: 10.1097/PAS.0b013e31816be8b7Authors: Cho, Mee-Yon MD, PhD *; Kim, Hyun Soo MD, PhD +; Eng, Charis MD, PhD ++; Kim, Dae Sung MD, PhD [S]; Kang, Seong Joon MD, PhD [S]; Eom, Minseob MD *; Yi, Sang Yeop MD, PhD [//]; Bronner, Mary P. MD [P] (Source: The American Journal of Surgical Pathology)

The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary.

Gynecologic Oncology — Thu, 19 Jun 2008 04:00:00 +0100

CONCLUSIONS: Prevalence of lymph node metastasis varies according to histology in OGCT and is an independent predictor of poor survival in these patients. These findings highlight the value of lymphadenectomy and may be helpful in creating risk stratification models for individualization of adjuvant therapies. PMID: 18571705 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

The influence of conservative surgical practices for malignant ovarian germ cell tumors

Journal of Surgical Oncology — Wed, 18 Jun 2008 04:00:00 +0100

To evaluate demographics, survival, and surgical trends for patients with malignant ovarian germ cell tumors.SEER data abstracted from 1988 to 2001 and analyzed using Kaplan-Meier and Cox regression models.Of 760 patients, the median age was 23 years. Seventy-six percent of patients presented with stage I-II disease, and 24% with stage III-IV. Fifty-five percent were immature teratomas, 32% dysgerminomas, and 13% yolk sac tumors. Fertility-preserving surgery was performed in 41.2% (n = 313) of patients. In those (Source: Journal of Surgical Oncology)

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Fluorescence in situ hybridization of 12p in germ cell tumors using a bacterial artificial chromosome clone 12p probe on paraffin-embedded tissue: clinical test validation.

Cancer Genetics and Cytogenetics — Wed, 28 May 2008 15:27:27 +0100

We describe an interphase FISH assay for detection of increased 12p copy number in germ cell tumors using a bacterial artificial chromosome-derived probe localized to 12p12.1 and a commercially available probe for the centromere of chromosome 12. Twenty-four paraffin-embedded blocks from 14 tumor cases (7 malignant mixed germ cell tumors, 2 dysgerminomas, 4 non-germ cell malignancies arising in germ cell tumors, and 1 mediastinal adenocarcinoma) and 18 normal controls were studied. Negative controls included normal lymph node, lung, and mediastinal tissue. The signals for 12p and 12cen were counted, and the ratio of the averaged signals was calculated; a ratio of 1.3 was considered positive. All germ cell tumors and non-germ cell malignancies arising in germ cell tumors were positive for 1...

Germ cell tumors of the ovary.

Cancer Treatment Reviews — Sat, 29 Mar 2008 04:00:00 +0100

CONCLUSION: MOGCTs are rare neoplasms that affect girls and young women and have excellent prognosis at all stages of disease with optimal therapy. The majority of MOGCTs patients retain their reproductive function. PMID: 18378402 [PubMed - as supplied by publisher] (Source: Cancer Treatment Reviews)

Influence of Tumor Site and Histology on Long-Term Survival in 193 Children with Extracranial Germ Cell Tumors

European Journal of Pediatric Surgery — Wed, 27 Feb 2008 09:37:00 +0100

Eur J Pediatr Surg 2008; 18: 1-6DOI: 10.1055/s-2007-989399Abstract Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histological analysis revealed 152 teratomas (mature: 115, immature: 37), 27 yolk sac tumors, 8 mixed tumors, 2 dysgerminomas, 2 gonadoblastomas, 1 choriocarcinoma and 1 embryonal ...

Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation.

Cancer Letters — Thu, 21 Feb 2008 05:00:00 +0100

Authors: Palma I, Peña RY, Contreras A, Ceballos-Reyes G, Coyote N, Eraña L, Kofman-Alfaro S, Queipo G Gonadoblastoma (GB) is an in situ tumor consisting of a heterogeneous population of mature and immature germ cells, other cells resembling immature Sertoli/granulosa cells, and Leydig/lutein-like cells, may also be present. GB almost exclusively affects a subset of patients with intersex disorders and in 30% of them overgrowth of the germinal component of the tumor is observed and the lesion is term dysgerminoma/seminoma. Several pathways have been proposed to explain the malignant process, and abnormal OCT3/4 expression is the most robust risk factor for malignant transformation. Some authors have suggested that OCT3/4 and beta-catenin might both be involved in the same onc...

[Swyer syndrome: A five-cases report.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Thu, 31 Jan 2008 05:00:00 +0100

CONCLUSION: The risk of gonadal neoplasia is high, dictating early prophylactic removal of these dysgenesic gonads. PMID: 18242875 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

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Clinical analysis of 57 patients with ovarian dysgerminoma

Chinese Journal of Clinical Oncology — Thu, 03 Jan 2008 19:45:24 +0100

Conclusions The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving operation can be considered in early -staged patients, but caution needs to be exercised in the middle to late staged cases. Good results can be achieved with an operation-based combined modality in recurrent patients. Content Type Journal ArticleCategory Original ArticlesDOI 10.1007/BF02782179Authors Yanfang Li, Sun Yat-sen University Department of Gynecologic Oncology, Cancer Center 510060 Guangzhou ChinaMenda LP, Sun Yat-sen University Department of Gynecologic Oncology, Cancer Center 510060 Guangzhou ChinaQiuliang WU, Sun Yat-sen University Department of Pathology, Cancer Center 510060 Guangzhou ChinaFuyuan Liu, Sun Yat-sen Unive...

Y chromosomal sequences identified in gonadal tissue of two 45,X patients with turner syndrome

Endocrine Pathology — Thu, 08 Nov 2007 16:11:48 +0100

We examined excised gonadal tissue obtained from two 45,X patients for evidence of Y chromosomal material. Both patients had features atypical for individuals with Turner syndrome, a large dysgerminoma in patient 1 and clitoromegaly in patient 2. Southern blot analysis of polymerase chain reaction (PCR)-amplified DNA was performed for five Y chromosome-specific probes (SRY, ZFY, DYZ3, KALY, and DYZ1). Fluorescencein situ hybridization (FISH) with a combination probe specific for the DYZ1/DYZ3 loci was utilized. For both patients, Southern blot analysis of PCR-amplified DNA with primers for the SRY gene was positive. No signals were detected with the other Y chromosome-specific probes for patient 1. For patient 2, positive signals were obtained for all Y-specific probes. FISH was negat...

Müllerian inhibiting substance type II receptor (MISIIR): A novel, tissue-specific target expressed by gynecologic cancers.

Gynecologic Oncology — Mon, 05 Nov 2007 05:00:00 +0100

CONCLUSIONS.: In the largest study to date, we report that MISIIR is highly expressed by a wide variety of gynecologic cancers, including cancers currently without effective systemic therapies. Low levels of expression in select non-gynecologic tissues coupled with high expression in gynecologic malignancies make MISIIR an attractive target for novel therapeutics and tumor-directed imaging in the management of gynecologic cancers. Further investigation into the impact of MISIIR expression and OS is also warranted. PMID: 17988723 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

High-throughput microRNAome analysis in human germ cell tumours

The Journal of Pathology — Mon, 24 Sep 2007 04:00:00 +0100

We reported previously that the miRNAs hsa-miR 371-373 cluster is involved in overruling cellular senescence induced by oncogenic stress, allowing cells to become malignant. Here we report the first high-throughput screen of 156 microRNAs in a series of type II and III GCTs (n = 69, in duplicate) using a quantitative PCR-based approach. After normalization to allow inter-sample analysis, the technical replicates clustered together, and the previous hsa-miRNA 371-373 cluster finding was confirmed. Unsupervised cluster analysis demonstrated that the cell lines are different from the in vivo samples. The in vivo samples, both normal and malignant, clustered predominantly based on their maturation status. This parallels normal embryogenesis, rather than chromosomal anomalies in the tumours. mi...

A case of dysgerminoma of the ovary with early carcinomatous features

Histopathology — Mon, 25 Jun 2007 13:06:27 +0100

Histopathology Volume 0, Issue 0, Page ???-???. (Source: Histopathology)

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Dysgerminoma in three patients with Swyer syndrome

World Journal of Surgical Oncology — Sat, 23 Jun 2007 04:00:00 +0100

Conclusion: In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done. (Source: World Journal of Surgical Oncology)

Could ovarian choriocarcinoma be detected by maternal serum screening for Down syndrome?

Prenatal Diagnosis — Tue, 29 May 2007 04:00:00 +0100

The incidence of ovarian malignancies during gestation ranges from 1 in 8000 to 1 in 20 000 deliveries. Ovarian malignancies that produce human chorionic gonadotropin (hCG) are limited to germ cell tumors, of which dysgerminoma is the most frequent (45%) malignant type encountered in pregnant patients, the others being ovarian choriocarcinoma and mixed germ cell tumors . In women of childbearing age, it is hard to distinguish between metastatic choriocarcinoma on a complete mole and primary ovarian choriocarcinoma. Treatment is based on adnexectomy followed by chemotherapy. Given the extreme rarity of these tumors, the long-term prognosis is difficult to establish. Had the diagnosis for our patient been made during pregnancy, the therapeutic approach would have been discussed in terms of g...

[Malignant ovarian germ cell tumours: a trial of 36 cases.]

Gynecologie, Obstetrique & Fertilite — Tue, 01 May 2007 04:00:00 +0100

CONCLUSION: Surgery in a young patient with malignant ovarian germ cells tumours must be conservative (adnexectomy) (preserving fertility and because of good prognostic). In case of stage IA with part of dysgerminoma and/or immature teratoma and/or embryonal carcinoma certified by surgical staging, strict follow up could be organized (clinic, radiology, AFP, HCG). In case of more than stage IA, chemotherapy is indicated after conservative surgery and surgical staging. PMID: 17350873 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)

Prognostic factors and role of salvage surgery in chemorefractory ovarian germ cell malignancies: A study in Chinese patients.

Gynecologic Oncology — Mon, 23 Apr 2007 04:00:00 +0100

CONCLUSIONS.: Chemorefractory cases with dysgerminoma or immature teratoma appear to have better outcome than the other subtypes. When offered standard BEP/PVB regimen as salvage chemotherapy, patients with chemorefractory disease after non-BEP/PVB primary chemotherapy have better prognosis. Optimal cytoreduction during salvage surgery does benefit chemorefractory patients. PMID: 17459461 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminoma

Archives of Gynecology and Obstetrics — Wed, 07 Mar 2007 07:43:08 +0100

Conclusion??This case report illustrates the difficulties arising from diagnosis of malignancy during pregnancy. Although combined treatment with paclitaxel and carboplatin is not considered a first-line therapy for ovarian dysgerminoma, in this case report it elicited an excellent response, and there were no adverse effects on the foetus. Content TypeJournal Article JournalArchives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

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Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers

Molecular Cancer — Fri, 02 Feb 2007 05:00:00 +0100

Conclusion: This study provides new data supporting two distinct but overlapping pathways in OGCT development; one involving spontaneous KIT mutation(s) leading to increased survival and proliferation of undifferentiated oogonia, the other related to presence of Y chromosome material and ensuing gonadal dysgenesis in phenotypic females. (Source: Molecular Cancer)

Ovarian dysgerminoma and Apert syndrome

Pediatric Blood and Cancer — Mon, 22 Jan 2007 07:00:00 +0100

We report the case of a 13-year-old female with Apert syndrome who developed an ovarian dysgerminoma. The FGFR2 exon 7 sequencing showed the classical Apert syndrome c.758C > G transversion (p.Pro253Arg). The genomic analyses of the tumor cells showed low level gains and losses of several chromosomes. This is the second report of the association of Apert syndrome with cancer. Our observation raises the hypothesis of a role for FGFR2 mutations in tumorigenesis. Pediatr Blood Cancer © 2007 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)

OCT4: biological functions and clinical applications as a marker of germ cell neoplasia

The Journal of Pathology — Tue, 21 Nov 2006 07:00:00 +0100

Germ cell tumours (GCTs) are a heterogeneous group of neoplasms, which develop in the gonads as well as in extragonadal sites, that share morphological patterns and an overall good prognosis, owing to their responsiveness to current surgical, chemotherapeutic, and radiotherapeutic measures. GCTs demonstrate extremely interesting biological features because of their close relationships with normal embryonal development as demonstrated by the pluripotentiality of some undifferentiated GCT variants. The similarities between GCTs and normal germ cell development have made it possible to identify possible pathogenetic pathways in neoplastic transformation and progression of GCTs. Genotypic and immunophenotypic profiles of these tumours are also useful in establishing and narrowing the different...

Laparotomy for post chemotherapy residue in ovarian germ cell tumors

Journal of Postgraduate Medicine — Wed, 15 Nov 2006 02:26:05 +0100

Conclusion</b> : Our study suggests that patients with absence of teratoma element initially, radiological residue of<5 cm and normalization of serum markers after two cycles of chemotherapy do not require surgery to assessthe nature of post-chemotherapy residue. However, laparotomy should be performed in patients with tumorsthat initially contain teratoma element and in those with sluggish tumor marker response after two cycles ofchemotherapy since they have a high chance of having viable postchemotherapy residue. (Source: Journal of Postgraduate Medicine)

Severe malignancy-associated hypercalcemia in dysgerminoma

Pediatric Blood and Cancer — Tue, 26 Sep 2006 03:33:02 +0100

We describe a 16-year-old girl with an ovarian dysgerminoma associated with severe hypercalcemia, a metabolic abnormality infrequently reported with this disease. We review some of the potential causes of malignancy-associated hypercalcemia and current treatment strategies. It is our recommendation that calcium levels should be monitored in all children with solid ovarian masses. Hypercalcemia seen in these situations may not improve until the tumor is removed. Pediatr Blood Cancer 2006; 47:621-623. © 2005 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)

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