MedWorm: Endometrial Cancer

HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation

AJP: Endocrinology and Metabolism — Fri, 19 Mar 2010 20:12:53 +0100

Expression of the GABAA receptor has been described previously in the human endometrium in both luminal epithelium and stroma. Its expression is increased during decidualization in rodents and in the implantation window of human endometrium. Here we localized GABA subunit receptor protein in human endometrium and identified regulators of gene expression and activation. GABAA was localized to the cell surface, and expression increased during the window of embryo implantation in human endometrium. The well-differentiated human endometrial adenocarcinoma cell line Ishikawa was treated with progesterone and transfected with pcDNA-HOXA10, HOXA10 siRNA, or respective controls. GABAA receptor mRNA expression was evaluated by real-time RT-PCR. Protein expression and localization were evaluated usi...

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New chemotherapy combination shows promise in endometrial cancer, researchers find

ScienceDaily Headlines — Fri, 19 Mar 2010 09:00:00 +0100

Researchers report that in a small study of women with advanced or recurrent endometrial cancer, gemcitabine and cisplatin, when used in combination, produced a response rate in fifty percent of patients. (Source: ScienceDaily Headlines)

New Chemotherapy Combination Shows Promise In Endometrial Cancer

Health News from Medical News Today — Fri, 19 Mar 2010 07:00:00 +0100

Researchers from The University of Texas M. D. Anderson Cancer Center report that in a small study of women with advanced or recurrent endometrial cancer, gemcitabine and cisplatin, when used in combination, produced a response rate in fifty percent of patients. Jubilee Brown, M.D., associate professor in M. D. Anderson's Department of Gynecologic Oncology, presented the findings at the plenary session of the Society of Gynecologic Oncologists' 41st Annual Meeting on Women's Cancer... (Source: Health News from Medical News Today)

New Chemotherapy Combination Shows Promise In Endometrial Cancer

Cancer / Oncology News From Medical News Today — Fri, 19 Mar 2010 07:00:00 +0100

State-of-the-art of non-hormonal methods of contraception: III. Intrauterine devices.

The European Journal of Contraception and Reproductive Health Care — Fri, 19 Mar 2010 02:10:20 +0100

Authors: Sivin I, Batár I Since the 1959 revival of the IUD, non-hormonal devices have become the most widely used of all reversible contraceptives. Pregnancy rates of copper-releasing IUDs in current use range from approximately 0.5 to 1.5 per hundred continuing users in the first year, with somewhat lower annual pregnancy rates thereafter. Evidence-based research has been systematically conducted and translated into guidelines for eligibility criteria and problem management. Recent device research, beyond the T, Multiload and frameless devices has centred on improved designs such as U ,Y and Slimline shapes, or enhanced copper release, the latter through electrochemical effects or nanotechnology applications. Other IUD research foci concern devices that decrease bleeding and pai...

Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms

Modern Pathology AOP — Fri, 19 Mar 2010 00:00:00 +0100

Authors: Laura J Tafe, Karuna Garg, Ivy Chew, Carmen Tornos & Robert A Soslow (Source: Modern Pathology AOP)

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New chemotherapy combination for endometrial cancer

Medicineworld.org: New Article Alert — Thu, 18 Mar 2010 02:19:18 +0100

Scientists from The University of Texas M. D. Anderson Cancer Center report that in a small study of women with advanced or recurrent endometrial cancer, gemcitabine and cisplatin, when used in combination, produced a response rate in fifty percent of patients. Jubilee Brown, M.D., associate professor in M. D. Anderson's Department of Gynecologic Oncology, presented the findings at today's plenary session of the Society of Gynecologic Oncologists' 41st Annual Meeting on Women's Cancer........ (Source: Medicineworld.org: New Article Alert)

SGO: Hint of Chemoprevention Potential for Lynch Syndrome (CME/CE)

MedPage Today Hematology/Oncology — Wed, 17 Mar 2010 14:13:06 +0100

SAN FRANCISCO (MedPage Today) -- Oral contraceptives and medroxyprogesterone acetate (MPA, DepoProvera) may have potential as chemopreventive agents for endometrial cancer in women with Lynch syndrome, biomarker data from a small randomized trial suggest. (Source: MedPage Today Hematology/Oncology)

Researchers find new chemotherapy combination shows promise in endometrial cancer

EurekAlert! - Medicine and Health — Wed, 17 Mar 2010 04:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) Researchers from the University of Texas M. D. Anderson Cancer Center report that in a small study of women with advanced or recurrent endometrial cancer, gemcitabine and cisplatin, when used in combination, produced a response rate in fifty percent of patients. (Source: EurekAlert! - Medicine and Health)

Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells

Journal of Cellular Biochemistry — Tue, 16 Mar 2010 00:00:00 +0100

In conclusion, curcumin suppresses JAK-STAT signaling via activation of PIAS-3, thus attenuating STAT-3 phosphorylation and tumor cell growth. J. Cell. Biochem. © 2010 Wiley-Liss, Inc. (Source: Journal of Cellular Biochemistry)

Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance

Virchows Archiv — Mon, 15 Mar 2010 17:55:00 +0100

This study investigated the relationship between the immunohistochemical expression of mtTFA and various clinicopathological variables in 276 endometrial carcinomas, including 245 endometrioid adenocarcinomas and 31 nonendometrioid carcinomas (21 serous carcinomas and 10 clear cell adenocarcinomas). Both uni- and multivariate regression analyses were performed. The mtTFA labeling index of endometrioid adenocarcinomas ranged from 0% to 98%, with a median value of 32%, which was selected as the cut-off point for mtTFA expression. The mtTFA expression in endometrioid adenocarcinomas was significantly associated with the surgical stage, myometrial invasion, lymphovascular space invasion, cervical invasion, and lymph node metastasis. In contrast, no correlation between clinicopathologic v...

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From floated to conventional confidence intervals for the relative risks based on published dose–response data

Computer Methods and Programs in Biomedicine — Mon, 15 Mar 2010 16:49:02 +0100

Abstract: A dose–response meta-analysis of epidemiological studies can encounter different types of confidence intervals (floated vs. conventional). This paper illustrates how to back calculate conventional confidence intervals from a set of relative risks reported with floated confidence intervals or floated standard errors. Furthermore, we provide an implementation of the formulas in a user-friendly program developed for Stata software. I exemplify the point using published data about alcohol intake and endometrial cancer incidence from the Million Women Study. (Source: Computer Methods and Programs in Biomedicine)

Endometrial hyperplasia: a clinician's review

Obstetrics, Gynaecology and Reproductive Medicine — Mon, 15 Mar 2010 15:07:39 +0100

Abstract: Endometrial hyperplasia is considered present when the ratio of glandular to stromal tissue of the endometrium is greater than 1:1. Further differentiation is made into simple or complex hyperplasia with or without the presence of cytological atypia. Such changes are caused by excess or unopposed oestrogenic stimulation. Clinically endometrial hyperplasia is often asymptomatic but can present as abnormal uterine bleeding. Many cases are detected incidentally or following abnormal vaginal bleeding by an increase in the normal endometrial thickness on transvaginal ultrasonography (TVS). An endometrial biopsy can be obtained using a pipelle or at hysteroscopy, and examination of this allows a histological diagnosis. Cytological atypia mandates active intervention as its presence cor...

Heterogeneous expression of nestin in myofibroblasts of various human tissues

Pathology International — Mon, 15 Mar 2010 00:00:00 +0100

In conclusion, nestin was expressed in variable proportions of stromal myofibroblasts in human tissues. The differential expression of nestin may indicate phenotypic and functional heterogeneity. Nestin-positive myofibroblast may represent a relatively immature subpopulation of cells with multipotentiality. (Source: Pathology International)

Increased Rate of Glucose Intolerance in Endometrial Cancer a Community-Based Study

Gynecologic and Obstetric Investigation — Sun, 14 Mar 2010 23:00:00 +0100

Gynecol Obstet Invest 1984;18:190-193 (DOI:10.1159/000299079) (Source: Gynecologic and Obstetric Investigation)

Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer

Angiogenesis — Sun, 14 Mar 2010 12:26:49 +0100

Abstract Tumor neovascularization is a complex process that plays a crucial role in the development of many different types of cancer. Vascular endothelial growth factor (VEGF) is a potent mitogen that is involved with mitogenesis, angiogenesis, endothelial survival, and the induction of hematopoiesis. By increasing vascular permeability in endothelial cells, it helps tumors recruit wound-healing proteins fibrin and fibrinogen from the plasma, suggesting that tumor formation is a process of abnormal wound healing dependent on the ability to generate a blood supply. The human female reproductive tract is highly dependent on VEGF for normal functions such as endometrial proliferation and development of the corpus luteum. The unique influence of female sex steroid hormones on...

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Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.

Technology in Cancer Research and Treatment — Sun, 14 Mar 2010 07:46:15 +0100

In this study, we used genome-wide microarray-based comparative genomic hybridization (aCGH) technology to characterize five of the more commonly used endometrial cancer cell lines. We detected DNA copy-number gains in chromosomal regions 2q, 3p, 3q, 5q, 7p, 17q, and19q in all five cell lines. Other common sites of copy-number gains, which were detected in four of five cell lines, included segments of chromosomes 1, 6, 8, 9, 11, 12, and 16. In all five cell lines, we found DNA copy-number losses in regions 3p, 10p, 10q, 11q, 11p, 14q, 15q, 18p, and 21q. Other common sites of genetic aberrations included segments of chromosomes 1, 2, 4, 5, 6, 16, 20, and 22. The genes involved in the copy-number alterations included the oncogenes PIK3CA (3q26.3), K-ras (12p12.1), R-ras (19q13.3-qter), Raf-1...

RE: "Stage 1, Grade 3 endometrioid adenocarcinoma of the endometrium: An analysis of clinical outcomes and patterns of recurrence"

Gynecologic Oncology — Sat, 13 Mar 2010 00:00:00 +0100

Authors: O'Malley DM, Fader AN, Rasool N PMID: 20231033 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Pelvic/Para-Aortic Lymphadenectomy May Improve Survival Time From Endometrial Cancer

Medscape Today Headlines — Thu, 11 Mar 2010 18:02:54 +0100

In medium- to high-risk patients with endometrial cancer, systematic removal of pelvic as well as para-aortic lymph nodes may improve survival time vs pelvic lymphadenectomy alone. Medscape Medical News (Source: Medscape Today Headlines)

A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis

International Journal of Clinical Oncology — Thu, 11 Mar 2010 02:49:58 +0100

We present a case of clear cell carcinoma located in the diaphragm in a patient with a medical history of ovarian endometriosis. Ultrasonography revealed the presence of a 2.5-cm nodule on the surface of the liver in a 65-year-old woman. She had undergone right salpingo-oophorectomy for treatment of an endometrial cyst of the right ovary at the age of 43 years and hysterectomy for treatment of a myoma of the uterus at the age of 51 years. We performed laparotomy and found that the tumor had originated from the diaphragm and invaded the liver. The diaphragm and liver were partially resected. Histopathological examination revealed the presence of clear cells and hobnail cells. The clear cells contained pale or eosinophilic cytoplasm and were arranged in a solid pattern. The h...

Distinguishing between primary endocervical and endometrial adenocarcinomas: is a 2-marker (Vim/CEA) panel enough?

Virchows Archiv — Thu, 11 Mar 2010 02:40:39 +0100

In this study, our aim is to investigate whether a 2-marker panel is enough to distinguish between these two gynecologic malignancies. Additionally, we wish to determine which one is the most favorable among eight panels tested, including six 2-marker (ER/CEA, PR/CEA, Vim/CEA, ER/p16INK4a, PR/p16INK4a, Vim/p16INK4a) and two 3-marker (ER/Vim/CEA, ER/Vim/p16INK) panels. A tissue microarray was constructed using paraffin-embedded, formalin-fixed tissues from 35 hysterectomy specimens, including 14 primary endocervical adenocarcinomas and 21 primary endometrial adenocarcinomas. Utilizing the avidin-biotin complex (ABC) method, tissue array sections were immunostained with five commercially available antibodies (ER, Vim, CEA, PR, and p16INK4a) to evaluate their individual frequencies of ex...

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Prolonged long-term survival of low-grade endometrial stromal sarcoma patients with lung metastasis following treatment with medroxyprogesterone acetate

International Journal of Clinical Oncology — Wed, 10 Mar 2010 16:13:27 +0100

Conclusion The patients in this study demonstrate that MPA treatment may extend the survival of patients with LGESS that is metastatic to the lung. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0040-2Authors Kentaro Nakayama, Shimane University School of Medicine Department of Obstetrics and Gynecology 89-1 Enyacho Izumo 693-8501 JapanMasako Ishikawa, Shimane University School of Medicine Department of Obstetrics and Gynecology 89-1 Enyacho Izumo 693-8501 JapanYutaka Nagai, University of the Ryukyus Department of Obstetrics and Gynecology, Faculty of Medicine 207 Uehara, Nishihara Okinawa 903-0215 JapanNobuo Yaegashi, Tohoku University Graduate School of Medicine Department of Obstetrics and Gynecology 1-1 Seiryo-machi, Aoba-ku Sendai 98...

Assessment of gross examination and frozen section of uterine specimen in endometrial cancer patients

Archives of Gynecology and Obstetrics — Wed, 10 Mar 2010 15:21:04 +0100

Conclusion These data confirm the previous reports for the accuracy of gross examination and frozen section diagnosis in early stage and low-grade tumors. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1387-3Authors Fatemeh Ghaemmaghami, Tehran University of Medical Sciences Gynecology Oncology Department, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex Keshavarz blvd. Tehran IranSoheila Aminimoghaddam, Tehran University of Medical Sciences Gynecology Oncology Department, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex Keshavarz blvd. Tehran IranMitra Modares-Gilani, Tehran University of Medical Sciences Gynecology Oncology Department, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex Keshavarz blvd. Tehran IranAzamosadat Mo...

Cervical polyps: evaluation of routine removal and need for accompanying D&C

Archives of Gynecology and Obstetrics — Wed, 10 Mar 2010 15:21:02 +0100

Conclusion Routine removal of cervical polyps, although not mandatory, seems clinically prudent because pathological evaluation is needed to confirm the diagnosis and to rule out other possibilities. 10.9% of postmenopausal patients and 7.8% of premenopausal patients were diagnosed with any endometrial pathology accompanying cervical polyp. Therefore, cervical polyps can be a sign of endometrial disease, especially in postmenopausal women with cervical polyp endometrium should be evaluated more carefully. Content Type Journal ArticleCategory General GynecologyDOI 10.1007/s00404-010-1405-5Authors Esra Esim Buyukbayrak, Dr. Lutfi Kirdar Kartal Education and Research Hospital Department of Gynecology Çanakkale cd. No: 26/11 Atalar, Kartal Istanbul TurkeyAyse Yasemin ...

Prospective external validation of the "ovarian crescent sign" as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology.

The Ultrasound Review of Obstetrics and Gynecology — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSION:: This study confirms previous reports that the presence of the OCS decreases the likelihood of invasive malignancy in adnexal masses. However it is a poor discriminator between benign and malignant adnexal masses. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20217895 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

Treatment options for advanced endometrial carcinoma.

Gynecologic Oncology — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: Clinical trials are planned to further explore how to best incorporate novel agents into the current treatment algorithm with the aim to improve the options in both first- and second-line treatments for women with endometrial adenocarcinomas. PMID: 20223510 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Vaginal Brachytherapy Instead of EBRT for Endometrial Cancer

Medscape Today Headlines — Mon, 08 Mar 2010 19:07:50 +0100

For women with endometrial cancer of high-intermediate risk, adjuvant therapy should be vaginal brachytherapy instead of external beam radiation therapy. Medscape Medical News (Source: Medscape Today Headlines)

Siteman, Washington University get $1.7M to tackle endometrial cancer

bizjournals.com Health Care:Biotechnology headlines — Mon, 08 Mar 2010 16:43:46 +0100

The National Cancer Institute has awarded the Siteman Cancer Center and Washington University School of Medicine in St. Louis a $1.7 million, three-year grant to study endometrial cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)

Combined pelvic, para-aortic lymphadenectomy improves endometrial cancer survival

MedWire News - Ob/Gyn — Mon, 08 Mar 2010 00:00:00 +0100

Endometrial cancer patients at medium to high risk for recurrence who receive complete combined pelvic and para-aortic lymphadenectomy have improved survival compared with patients who undergo removal of just the pelvic lymph nodes, show study findings. (Source: MedWire News - Ob/Gyn)

Polymorphism of the ERα and CYP1B1 genes in endometrial cancer in a Polish subpopulation

Journal of Obstetrics and Gynaecology Research — Sun, 07 Mar 2010 00:00:00 +0100

Conclusions: The CYP1B1 and ER[alpha] genes may play a role in endometrial cancer and the Arg48Gly (142C > G) -CYP1B1 and 975C > G-ER[alpha] polymorphisms may be considered as independent, early diagnostic markers in this disease. (Source: Journal of Obstetrics and Gynaecology Research)

Siteman, Wash. U get $1.7M grant

bizjournals.com Health Care:Biotechnology headlines — Sat, 06 Mar 2010 02:33:45 +0100

The Siteman Cancer Center and Washington University School of Medicine in St. Louis were awarded a three-year, $1.7 million grant by the National Cancer Institute (NCI) to study endometrial cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.

Gynecologic Oncology — Sat, 06 Mar 2010 00:00:00 +0100

CONCLUSIONS: Hypermethylation of CIDEA, HAAO and RXFP3 promoter regions appears to be a frequent event in endometrial carcinomas. Hypermethylation at these loci is strongly associated with microsatellite instability status. Moreover, HAAO methylation predicts disease-free survival in this cohort of patients with endometrioid endometrial cancer. PMID: 20211485 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Brachytherapy Called New Standard for Endometrial CA (CME/CE)

MedPage Today Hematology/Oncology — Fri, 05 Mar 2010 14:40:59 +0100

Endometrial cancer patients with intermediate recurrence risk may be better off with adjuvant internal radiotherapy than with external beam radiation, Dutch researchers said. (Source: MedPage Today Hematology/Oncology)

[Comment] Radiotherapy for endometrial cancer: a key piece in the jigsaw

LANCET — Fri, 05 Mar 2010 00:00:00 +0100

With a rising yearly incidence of more than 20 women per 100 000, endometrial cancer is now the most common gynaecological cancer in developed countries. More than 75% of patients present with disease confined to the uterus. After hysterectomy and bilateral salpingo-oophorectomy, histopathological variables are used to assign risk of recurrence. Endometrial cancer of high-intermediate risk accounts for around 30% of women with early disease, of whom about 15% either have occult metastases or will develop metastatic disease. Adjuvant treatment to reduce the risk of recurrence has traditionally been external beam radiotherapy (EBRT), which is presently offered to about a third of women with endometrial cancer, with or without vaginal brachytherapy (VBT). However, although EBRT reduces the r...

[Articles] Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial

LANCET — Fri, 05 Mar 2010 00:00:00 +0100

This study established whether vaginal brachytherapy (VBT) is as effective as pelvic external beam radiotherapy (EBRT) in prevention of vaginal recurrence, with fewer adverse effects and improved quality of life. (Source: LANCET)

Vaginal radiotherapy better option for cancer

OnMedica Latest News — Fri, 05 Mar 2010 00:00:00 +0100

Internal vaginal radiotherapy as effective as external, with fewer side-effectsRelated items from OnMedicaHerceptin of benefit in more breast cancer casesGuideline to help GPs spot cervical cancer earlyWider surgery improves endometrial Ca survivalMortality higher if using paroxetine and tamoxifenCancer survival rates not improved much in a decade (Source: OnMedica Latest News)

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Vaginal Brachytherapy May Be Best for Endometrial Cancer

Modern Medicine — Fri, 05 Mar 2010 00:00:00 +0100

In patients with high-intermediate-risk endometrial cancer, vaginal brachytherapy is just as effective as pelvic external beam radiotherapy for prevention of vaginal recurrence, has fewer toxic effects and leads to improved quality of life, according to a study in the March 6 issue of The Lancet. (Source: Modern Medicine)

Uterine Tumors with Neuroectodermal Differentiation. A Report of 4 Cases.

Pathology Oncology Research — Fri, 05 Mar 2010 00:00:00 +0100

We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic p...

Effects of HPV-16 E5, E6 and E7 proteins on survival, adhesion, migration and invasion of trophoblastic cells

Carcinogenesis — Thu, 04 Mar 2010 15:26:26 +0100

In conclusion, HPV-16 early proteins enhanced trophoblastic growth and intensify the malignant phenotype by impairing cell adhesion leading to increased cellular motile and invasive properties. HPV-16 E5 participated, with E6 and E7, in these changes by impairing E-cadherin expression, a hallmark of malignant progression. (Source: Carcinogenesis)

The usefulness of immunohistochemistry in tissue microarrays of Human Papillomavirus negative adenocarcinoma of the uterine cervix

BioMed Central — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: The immunoprofiles of ADC with the antibodies studied are rather nonspecific. By using immunohistochemistry in 13 HPV negative ADC, endocervical tumour origin was suspected in five CEA positive cases while two out of three vimentin positive samples were probably of endometrial origin, suggesting that CEA and vimentin may be valuable in distinguishing HPV negative cervical adenocarcinomas from endometrial adenocarcinomas. (Source: BioMed Central)

Artifactual hypoglycaemia secondary to leukaemoid reaction

Practical Diabetes International — Wed, 03 Mar 2010 00:00:00 +0100

Artifactual hypoglycaemia presents clinically as asymptomatic hypoglycaemia, and may be associated with an increased white blood cell count. The authors report a case of artifactual hypoglycaemia secondary to leukaemoid reaction in a patient with endometrial adenocarcinoma. Following thorough investigation and exclusion of true hypoglycaemia, this phenomenon was eventually diagnosed. The importance of awareness in the clinically asymptomatic patient of this phenomenon, taking measures to reduce erroneous laboratory glucose results, and confirmatory testing with a glucometer is emphasised. Copyright © 2010 John Wiley & Sons. (Source: Practical Diabetes International)

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Dietary glycemic index and load in relation to risk of uterine leiomyomata in the Black Women's Health Study.

The American Journal of Clinical Nutrition — Wed, 03 Mar 2010 00:00:00 +0100

CONCLUSIONS: Our results suggest that high dietary GI and GL may be associated with an increased UL risk in some women. The observed associations warrant investigation in future studies. PMID: 20200259 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)

Pseudoneoplastic lesions of the female genital tract.

Archives of Pathology and Laboratory Medicine — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions.-Many benign hyperplastic or reactive processes that occur in the female genital tract may be mistaken for neoplasms both clinically and pathologically. Awareness of the features of such lesions will aid in their correct diagnosis and prevent overtreatment of benign processes. PMID: 20196667 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.

Gynecologic Oncology — Mon, 01 Mar 2010 00:00:00 +0100

CONCLUSIONS.: Genetic variants in CYP11A1 may influence endometrial cancer risk or may be markers for causal variants elsewhere. Polymorphisms in StAR are not associated with endometrial cancer risk, but further research is needed. PMID: 20199803 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Clinicopathologic features of bone metastases and outcomes in patients with primary endometrial cancer.

Gynecologic Oncology — Mon, 01 Mar 2010 00:00:00 +0100

CONCLUSION: Although a rare event, endometrial cancer can metastasize to the bone. If a bone lesion is identified, treatment using a multimodality approach is reasonable, especially if found as an isolated recurrence. PMID: 20199802 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Robotic Pelvic and Aortic Lymphadenectomy for Endometrial Cancer: The Console Surgeon's Perspectives on Surgical Technique and Directing the Assistant

The Journal of Minimally Invasive Gynecology — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions: A systematic routine and effective use of the bedside assistant is essential for successfully completing robotic hysterectomy and aortic and pelvic lymphadenectomy. This manuscript and video illustrates our method emphasizing an efficient and comprehensive technique for this procedure. (Source: The Journal of Minimally Invasive Gynecology)

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Endometrial Stromal Sarcomas: A Review of Potential Prognostic Factors

Advances in Anatomic Pathology — Mon, 01 Mar 2010 00:00:00 +0100

Endometrial stromal tumors are uncommon mesenchymal tumors of the uterus. The classification of these tumors has evolved and the most current World Health Organization classification (2003) divides these neoplasms into: endometrial stromal nodule, low-grade endometrial stromal sarcoma, and undifferentiated endometrial sarcoma. The salient clinicopathologic features of these tumors are described, and a comprehensive review of literature pertaining to potential prognostic factors in endometrial stromal sarcomas is provided. Clinical factors, including age, race, parity and menopausal status, and pathologic factors, including tumor size, tumor stage, nuclear atypia, mitotic activity, tumor necrosis, lymphovascular space invasion, DNA ploidy and proliferative activity, and expression of hormon...

Mullerian Adenosarcoma of the Female Genital Tract

Advances in Anatomic Pathology — Mon, 01 Mar 2010 00:00:00 +0100

Mullerian adenosarcoma is an uncommon, but not rare, mixed tumor containing a neoplastic but benign or mildly atypical epithelial element and a sarcomatous, usually low-grade, stromal component. The most common site is the uterine corpus but adenosarcoma also occurs in the cervix and ovary and more rarely in the vagina, fallopian tube, arising from peritoneal surfaces, or outside the female genital tract, for example in the intestine. Most uterine cases have a polypoid gross appearance, sometimes resulting in the formation of multiple polyps. Characteristic histologic features include a low power "phyllodes-like" architecture with leaf-like projections lined by a variety of benign Mullerian type epithelia, sometimes with squamous metaplasia. Intraglandular stromal protrusions are a charact...

New Data On Endometrial Cancer Epidemiology From Studies From The University Of Florida

Cancercompass News: Other Cancer — Sat, 27 Feb 2010 00:00:00 +0100

Fresh data on endometrial cancer are presented in the report 'Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.' Heat shock protein 70 (HSP70), an intracellular chaperone 'stress protein,' has been identified in the extracellular milieu, where it may exert regulatory effects upon monocytes. HSPs are overexpressed in many cancers and implicated in tumorigenesis, scientists in the United States report. (Source: Cancercompass News: Other Cancer)

Para-Aortic Lymphadenectomy May Improve Endometrial Cancer Survival

Medscape Ob/Gyn & Women's Health Headlines — Fri, 26 Feb 2010 15:51:40 +0100

Removal of para-aortic and pelvic lymph nodes in endometrial cancer patients may be linked with better overall survival than pelvic lymphadenectomy alone, Japanese researchers report in the February 25th online issue of The Lancet. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)

The Potential Mechanism of Tiliroside-Dependent Inhibition of t-Butylhydroperoxide-Induced Oxidative Stress in Endometrial Carcinoma Cells

Planta Medica — Fri, 26 Feb 2010 14:08:41 +0100

Planta MedDOI: 10.1055/s-0029-1240900AbstractThe effects of oxidative stress on collagen and DNA biosynthesis, -galactosidase activity, the expression of the -integrin receptor, FAK, the insulin-like growth factor-I receptor (IGF‐IR), the hypoxia-inducible factor-1 (HIF-1), and the mitogen-activated protein kinases (MAP/ERK, ERK) were evaluated in human endometrial carcinoma cells. Subconfluent cells were subjected to oxidative stress with 30 µM t-butylhydroperoxide (t-BHP) for 1 h per day over the course of 5 days. It was found that oxidative stress contributed to an increase in the -galactosidase activity as well as to the inhibition of collagen and DNA biosynthesis. The mechanism of the process was found at the level of IGF‐IR and HIF-1. An increase in the expre...

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Pelvic plus para-aortic lymphadenectomy best approach for intermediate, high-risk endometrial cancer

HemOncToday.com — Fri, 26 Feb 2010 09:37:00 +0100

(Source: HemOncToday.com)

Removing Lymph Nodes May Boost Endometrial Cancer Survival

MedicineNet Cancer General — Fri, 26 Feb 2010 07:00:00 +0100

Title: Removing Lymph Nodes May Boost Endometrial Cancer SurvivalCategory: Health NewsCreated: 2/25/2010 2:10:00 PMLast Editorial Review: 2/26/2010 (Source: MedicineNet Cancer General)

Removing Lymph Nodes May Boost Endometrial Cancer Survival

MedicineNet Womens Health General — Fri, 26 Feb 2010 07:00:00 +0100

Title: Removing Lymph Nodes May Boost Endometrial Cancer SurvivalCategory: Health NewsCreated: 2/25/2010 2:10:00 PMLast Editorial Review: 2/26/2010 (Source: MedicineNet Womens Health General)

Menopausal symptoms

Clinical Evidence — Thu, 25 Feb 2010 23:00:00 +0100

New evidence; conclusions changed for: Tibolone Two RCTs added comparing tibolone versus placebo. The first RCT found that tibolone (both 1.25 and 2.5 mg) reduced the frequency and severity of hot flushes at 12 weeks. The second RCT evaluated the risk of breast cancer recurrence with tibolone, and was stopped early after finding that tibolone significantly increased the rate of breast cancer at a median follow-up of 3.5 years.Categorisation changed (from Beneficial to Trade-off between benefits and harms). New evidence; conclusion confirmed for: Oestrogens alone Three RCTs evaluating vasomotor symptoms added. All three RCTs found that oestrogen reduced hot-flush frequency and severity compared with placeb...

Removing Lymph Nodes May Boost Endometrial Cancer Survival

MedlinePlus Health News — Thu, 25 Feb 2010 19:00:00 +0100

For medium- to high-risk women, more surgery is better, study shows Source: HealthDay Related MedlinePlus Pages: Lymphatic Diseases, Uterine Cancer (Source: MedlinePlus Health News)

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Extent of Lymph Node Resection Key to Endometrial CA Survival (CME/CE)

MedPage Today Hematology/Oncology — Thu, 25 Feb 2010 16:59:30 +0100

More extensive lymph node excision may boost survival for endometrial cancer patients with at least an intermediate risk of recurrence, Japanese researchers found. (Source: MedPage Today Hematology/Oncology)

Endometrial Cancer: The Complete Removal Of Lymph Nodes Improves Survival (SEPAL Study)

Health News from Medical News Today — Thu, 25 Feb 2010 08:00:00 +0100

The conclusions of the SEPAL study are published Online First. It reports that a complete, systematic removal of both pelvic lymph nodes (lymphadenectomy) and para-aortic lymph nodes, improves survival compared with removal of just the pelvic lymph nodes. The para-aortic lymph nodes are a group of lymph nodes that lie in front of the lumbar vertebral bodies near the aorta. These lymph nodes receive drainage from the lower gastrointestinal tract and the pelvic organs. The findings are relevant for patients at medium to high risk of cancer recurrence... (Source: Health News from Medical News Today)

Endometrial Cancer: The Complete Removal Of Lymph Nodes Improves Survival (SEPAL Study)

Cancer / Oncology News From Medical News Today — Thu, 25 Feb 2010 08:00:00 +0100

The conclusions of the SEPAL study are published Online First. It reports that a complete, systematic removal of both pelvic lymph nodes (lymphadenectomy) and para-aortic lymph nodes, improves survival compared with removal of just the pelvic lymph nodes. The para-aortic lymph nodes are a group of lymph nodes that lie in front of the lumbar vertebral bodies near the aorta... (Source: Cancer / Oncology News From Medical News Today)

Wider surgery improves endometrial Ca survival

OnMedica Latest News — Thu, 25 Feb 2010 00:00:00 +0100

Women at high risk of recurrence need wider removal of lymph nodesRelated items from OnMedicaHerceptin of benefit in more breast cancer casesMortality higher if using paroxetine and tamoxifenMRI in breast cancer fails to cut reoperation rateCancer survival rates not improved much in a decade Symptoms don’t reliably predict ovarian cancer (Source: OnMedica Latest News)

Paper round: Thursday

OnMedica Latest News — Thu, 25 Feb 2010 00:00:00 +0100

"Unimaginable suffering" at hospital, soup salt danger, and moreRelated items from OnMedicaAge discrimination rife in breast cancer treatmentFalls prevention services are not evidence-basedOn the defensiveWider surgery improves endometrial Ca survivalNICE focuses on smoking prevention in schools (Source: OnMedica Latest News)

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Combination Procedure May Be Best for Endometrial Cancer

Modern Medicine — Thu, 25 Feb 2010 00:00:00 +0100

In endometrial cancer patients at high risk of recurrence, combined pelvic and para-aortic lymphadenectomy reduces the risk of recurrence significantly better than systemic pelvic lymphadenectomy, according to a study published online Feb. 25 in The Lancet. (Source: Modern Medicine)

Lasofoxifene in Postmenopausal Women with Osteoporosis

New England Journal of Medicine — Wed, 24 Feb 2010 00:00:00 +0100

Women between 59 and 80 years of age with a bone mineral density T score of -2.5 or less at the femoral neck or spine received the selective estrogen-receptor modulator lasofoxifene (either 0.25 or 0.5 mg daily) or placebo for 5 years. Lasofoxifene was associated with lower risks of fractures, estrogen-receptor-positive breast cancer, coronary heart disease, and stroke, with no increase in endometrial cancer, but there was an increase in venous thromboembolic events. (Source: New England Journal of Medicine)

Mast cells: Are they really related to invasiveness of endometrial carcinoma?

Pathology, Research and Practice — Wed, 24 Feb 2010 00:00:00 +0100

Authors: Go Ksu Erol YA, Ozdemir O PMID: 20188490 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

Relevance of Bcl-x expression in different types of endometrial tissues

Journal of Experimental and Clinical Cancer Research — Tue, 23 Feb 2010 00:00:00 +0100

Conclusion: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)

Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)--a randomised controlled trial of exemestane versus continued tamoxifen after 2-3 years tamoxifen

Annals of Oncology — Mon, 22 Feb 2010 13:25:35 +0100

Conclusion: Switching from tamoxifen to exemestane significantly reverses endometrial thickening associated with continued tamoxifen. (Source: Annals of Oncology)

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Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells.

Molecular and Cellular Biochemistry — Sun, 21 Feb 2010 00:00:00 +0100

Authors: Karna E, Szoka L, Palka JA Although betulinic acid (BA) is known to induce apoptosis and antiangiogenic response in tumor cells, the underlying mechanism of its action is unknown. Deregulation of tissue collagen metabolism is one of the consequences of neoplastic transformation. The final step of collagen degradation is mediated by prolidase [E.C.3.4.13.9] which may play a role in angiogenesis. The formation of new blood vessels is regulated by the hypoxia-inducible factor 1 (HIF-1). The expression of HIF-1 correlates with hypoxia-induced angiogenesis as a result of the induction of vascular endothelial cell growth factor (VEGF). Since BA evokes anticancer activity, its effect on collagen biosynthesis, HIF-1alpha and VEGF expressions, as well as prolidase activity and expressi...

Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility

Clinical Chemistry and Laboratory Medicine — Sat, 20 Feb 2010 16:50:33 +0100

Conclusions: This is the first report on the association of MMP-2, MMP-3 and MMP-7 gene polymorphisms in endometrial cancer. Our results suggest that individuals with the MMP-7 −181 G/G and A/G genotype may have an increased risk of developing endometrial cancer. Clin Chem Lab Med 2010;48:337–44. (Source: Clinical Chemistry and Laboratory Medicine)

The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas

Diagnostic Pathology — Thu, 18 Feb 2010 00:00:00 +0100

Conclusions Although our study provides additional evidence of the potential prognosticrole of c erbB 2, further prospective and controlled studies are required to validate theirclinical usefulness. (Source: Diagnostic Pathology)

Single gene mutation induces endometrial cancer

ScienceDaily Headlines — Fri, 12 Feb 2010 07:00:00 +0100

A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers have found. (Source: ScienceDaily Headlines)

Direct and Buffering Effects of Social Support Among Gynecologic Cancer Survivors.

Annals of Behavioral Medicine — Fri, 12 Feb 2010 00:00:00 +0100

CONCLUSIONS: These results suggest that circumstances for gynecologic cancer survivors burdened with physical symptoms may be worse for those with fewer support resources, providing needed insight into a common target of psychosocial interventions for cancer survivors. PMID: 20151235 [PubMed - as supplied by publisher] (Source: Annals of Behavioral Medicine)

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Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer.

Gynecologic Oncology — Fri, 12 Feb 2010 00:00:00 +0100

CONCLUSIONS: Subgroups of patients with non-endometrioid endometrial cancer and defective MMR may have improved survival after adjuvant radiotherapy. Patients with advanced stage endometrial cancer and defects in mismatch repair may receive less benefit from adjuvant chemotherapy. PMID: 20153885 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Studies From University Of North Carolina Add New Findings In The Area Of Endometrial Cancer

Cancercompass News: Other Cancer — Thu, 11 Feb 2010 00:00:00 +0100

According to recent research from the United States, Obesity and diabetes are strong risk factors that drive the development of type I endometrial cancers. Recent epidemiological evidence suggests that metformin may lower cancer risk and reduce rates of cancer deaths among diabetic patients. (Source: Cancercompass News: Other Cancer)

Fiber intake and endometrial cancer risk.

Acta Oncologica — Thu, 11 Feb 2010 00:00:00 +0100

Discussion. Data suggest the potential importance of lignin in the prevention of endometrial cancer at Italian consumption levels. PMID: 20148644 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Single Gene Mutation Induces Endometrial Cancer

Women's Health / OBGYN News From Medical News Today — Wed, 10 Feb 2010 11:00:00 +0100

A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers at UT Southwestern Medical Center have found in an animal study. The finding suggests that eventually it might be possible to screen women with endometrial cancer to see if they have that mutation and use the drug as targeted therapy, the researchers said... (Source: Women's Health / OBGYN News From Medical News Today)

Single Gene Mutation Induces Endometrial Cancer

Health News from Medical News Today — Wed, 10 Feb 2010 11:00:00 +0100

A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers at UT Southwestern Medical Center have found in an animal study. The finding suggests that eventually it might be possible to screen women with endometrial cancer to see if they have that mutation and use the drug as targeted therapy, the researchers said. "Our data suggest that deficiency of this gene can indicate both how aggressive an endometrial tumor will be and how well it might respond to a specific class of drugs," said Dr... (Source: Health News from Medical News Today)

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Hepatocyte Growth Factor System in the Mouse Uterus: Variation Across the Estrous Cycle and Regulation by 17-Beta-Estradiol and Progesterone.

Biology of Reproduction — Wed, 10 Feb 2010 00:00:00 +0100

In conclusion, HGF, HGFA and MET expression in mouse uterus changes during the estrous cycle in a stage-, cell type- and compartment-specific manner under the influence of estrogen and progesterone. HGF likely plays a role in cyclic endometrial remodeling such as cell proliferation via autocrine/paracrine mechanisms in mouse uterus. PMID: 20147731 [PubMed - as supplied by publisher] (Source: Biology of Reproduction)

Revealing A Potent Suppressor Of Endometrial Cancer

Women's Health / OBGYN News From Medical News Today — Tue, 09 Feb 2010 11:00:00 +0100

Revealing A Potent Suppressor Of Endometrial Cancer

Health News from Medical News Today — Tue, 09 Feb 2010 11:00:00 +0100

Endometrial cancer is the most common cancer of the female reproductive tract, representing 6% of all cancers. There is currently no screening method or biomarker to indicate early presence of disease. "It is a very common malignancy that affects women of all ages" comments paper author Dr. Diego Castrillon. The cancer forms from the cells that grow along the inner lining of the uterus, which is called the endometrium, and usually it is diagnosed following patient reports of abnormal bleeding... (Source: Health News from Medical News Today)

Single gene mutation induces endometrial cancer

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(UT Southwestern Medical Center) A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers at UT Southwestern Medical Center have found in an animal study. (Source: EurekAlert! - Medicine and Health)

Absolute Risk of Endometrial Carcinoma During 20-Year Follow-Up Among Women With Endometrial Hyperplasia [Epidemiology]

Journal of Clinical Oncology — Mon, 08 Feb 2010 23:01:40 +0100

Conclusion Cumulative 20-year progression risk among women who remain at risk for at least 1 year is less than 5% for nonatypical EH but is 28% for AH. (Source: Journal of Clinical Oncology)

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A potent suppressor of endometrial cancer is revealed

EurekAlert! - Social and Behavioral Science — Mon, 08 Feb 2010 05:00:00 +0100

(The Company of Biologists) Treatment of endometrial cancer has not advanced significantly in 30 years and there are no screening tests to promote early detection. Researchers at the University of Texas Southwestern Medical Center and Harvard Medical School developed a new approach to specifically target genetic changes to the endometrial cells in mice. Using this new technique, they show that loss of an emerging tumor suppressor causes abnormal growth and widespread malignancy of cells lining the uterus. (Source: EurekAlert! - Social and Behavioral Science)

A potent suppressor of endometrial cancer is revealed

ScienceDaily Headlines — Mon, 08 Feb 2010 05:00:00 +0100

Treatment of endometrial cancer has not advanced significantly in 30 years and there are no screening tests to promote early detection. Researchers have developed a new approach to specifically target genetic changes to the endometrial cells in mice. Using this new technique, they show that loss of an emerging tumor suppressor causes abnormal growth and widespread malignancy of cells lining the uterus. (Source: ScienceDaily Headlines)

Differences in the Soluble HLA-G Blood Serum Concentration Levels in Patients with Ovarian Cancer and Ovarian and Deep Endometriosis

American Journal of Reproductive Immunology — Mon, 08 Feb 2010 00:00:00 +0100

Conclusion sHLA-G blood serum concentration levels would seem to provide important information regarding the degree of immune system regulation disturbance in both ectopic endometrial cells and the cancer cell suppressive microenvironment. (Source: American Journal of Reproductive Immunology)

Surgical outcomes of robotic-assisted surgical staging for endometrial cancer are equivalent to traditional laparoscopic staging at a minimally invasive surgical center.

Gynecologic Oncology — Sat, 06 Feb 2010 00:00:00 +0100

CONCLUSION: Robotic-assisted surgery is an acceptable alternative to laparoscopy for minimally invasive staging of endometrial cancer. In addition to the improved ease of operation, visualization, and range of motion of the robotic instruments, robotic surgery results in a lower mean blood loss, although longer operative time. More data are needed to determine if the rates of urinary tract injuries and other surgical complications can be reduced with the use of robotic surgery. PMID: 20144471 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Vaginal polyp: an unusual cause of postmenopausal bleeding

Gynecological Surgery — Thu, 04 Feb 2010 18:12:06 +0100

We present this unusual case of fibroepithelial polyp of the vagina as a cause for PMB. Vaginal fibroepithelial polyp is a rare lesion, and although benign, it can be confused with malignant connective tissue lesions. Treatment is simple excision, and recurrence is extremely uncommon. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10397-010-0554-7Authors Janaki Putran, Colchester Hospital University NHS Foundation Trust Department of Obstetrics and Gynaecology Turner Road Colchester CO4 5JL UKRachana Gupta, Colchester Hospital University NHS Foundation Trust Department of Obstetrics and Gynaecology Turner Road Colchester CO4 5JL UK Journal Gynecological SurgeryOnline ISSN 1613-2084Print ISSN 1613-2076 (Source: Gynecological Surgery)

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Paraneoplastic consumptive coagulopathy related to intramyometrial low-grade endometrial stromal sarcoma coexistent with adenomyosis diagnosed 7 years after laparoscopic-assisted myomectomy

Archives of Gynecology and Obstetrics — Thu, 04 Feb 2010 18:10:08 +0100

Conclusions This case illustrates a rare but potentially life-threatening consumptive coagulopathy caused by intramyometrial low-grade ESS that was assumed to secondarily arise from stromal cells of adenomyosis developed in postmyomectomy scar. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1376-6Authors Akihiro Takeda, Gifu Prefectural Tajimi Hospital Department of Obstetrics and Gynecology 5-161 Maebata-cho Tajimi Gifu 507-8522 JapanSanae Imoto, Gifu Prefectural Tajimi Hospital Department of Obstetrics and Gynecology 5-161 Maebata-cho Tajimi Gifu 507-8522 JapanMasahiko Mori, Gifu Prefectural Tajimi Hospital Department of Obstetrics and Gynecology 5-161 Maebata-cho Tajimi Gifu 507-8522 JapanTomoko Nakano, Gifu Prefectural Tajimi Hospit...

Uterus conserving prolapse surgery—what is the chance of missing a malignancy?

International Urogynecology Journal — Thu, 04 Feb 2010 18:08:31 +0100

Conclusions Conserving a prolapsed uterus without further investigations runs the risk of missing women with endometrial malignancy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00192-010-1101-9Authors Arasee Renganathan, Medway Maritime Hospital London UKRobin Edwards, Medway Maritime Hospital Windmill Road Gillingham Kent ME7 5NY UKJonathan R. A. Duckett, Medway Maritime Hospital Windmill Road Gillingham Kent ME7 5NY UK Journal International Urogynecology JournalOnline ISSN 1433-3023Print ISSN 0937-3462 (Source: International Urogynecology Journal)

Role of Artemin in Endometrial Cancer Investigated

Modern Medicine — Thu, 04 Feb 2010 00:00:00 +0100

Endometrial tumors that produce high levels of artemin are more oncogenic and invasive, according to a study published online Jan. 29 in Endocrinology. (Source: Modern Medicine)

The Levels of the Endocannabinoid Receptor CB2 and Its Ligand 2-Arachidonoylglycerol Are Elevated in Endometrial Carcinoma.

Endocrinology — Thu, 04 Feb 2010 00:00:00 +0100

In conclusion, the endocannabinoid system seems to play an important role in human endometrial carcinoma, and modulation of CB2 activity/expression may account for a tumor-suppressive effect. PMID: 20133454 [PubMed - as supplied by publisher] (Source: Endocrinology)

Total laparoscopic hysterectomy with pelvic/aortic lymph node dissection for endometrial cancer-a consecutive series without case selection and comparison to laparotomy.

Gynecologic Oncology — Thu, 04 Feb 2010 00:00:00 +0100

CONCLUSIONS: For clinically localized endometrial cancer, TLH/BSO/LND can functionally duplicate operative time equivalent to "open" procedures, while improving nodal yield, and minimizing influence of BMI on conversion to laparotomy and case selection. PMID: 20138346 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Atypical Hyperplasia Carries High Long-Term Risk of Endometrial Cancer

Medscape Ob/Gyn & Women's Health Headlines — Wed, 03 Feb 2010 18:49:08 +0100

The cumulative 20-year risk of endometrial carcinoma for women with atypical endometrial hyperplasia is 28%, compared with a combined rate of less than 5% for women with simple or complex hyperplasia, according to a new report. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)

Endometrial cancer in Puerto Rico: incidence, mortality and survival (1992-2003)

BMC Cancer — Wed, 03 Feb 2010 00:00:00 +0100

Conclusions: The lower burden of endometrial cancer in Puerto Rico suggests the presence of protective factors or lower exposure to risk factors in this population, although increases in incidence suggest changes in the occurrence of lifestyles and environmental risk factors. Meanwhile, the lower five-year survival from endometrial cancer among Puerto Ricans suggests a health disparity for this group in areas such as quality of care and/or differences in terms of stage at diagnosis and associated comorbidities. Assessment of disease risk factors and characteristics, and access and response to treatment is required to further understand these results. (Source: BMC Cancer)

Role of Artemin in Endometrial Cancer Investigated

Modern Medicine — Wed, 03 Feb 2010 00:00:00 +0100

Endometrial tumors that produce high levels of artemin are more oncogenic and invasive, according to a study published online Jan. 29 in Endocrinology. (Source: Modern Medicine)

Fine Tuning of Endometrial Function by Estrogen and Progesterone Through microRNAs.

Biology of Reproduction — Wed, 03 Feb 2010 00:00:00 +0100

Authors: Lessey BA Progesterone suppresses estrogen at multiple levels in the normal secretory phase endometrium including the induction of microRNAs. If progesterone-stimulated miRNAs are disrupted, expression from the mRNA targets of each miRNA may fail to be suppressed, allowing excessive cell proliferation. In fact, recent work by others is already confirming the hypothesis that miRNAs are diagnostic smoking guns for various diseases like endometriosis. This is an area of intense investigation and one that is worth watching, especially for those interested in the endometrium, infertility, cancer, and even contraception. The study published in Biology of Reproduction by Kuokkanen et al. on miRNA expression in endometrial epithelium sets the stage to look for miRNAs as a mechanism fo...

Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers

JNCI — Tue, 02 Feb 2010 21:01:32 +0100

Conclusion We have obtained precise and accurate estimates of both absolute and relative cancer risks for MSH6 mutation carriers. (Source: JNCI)

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Molecular alterations in uterine serous carcinoma.

Gynecologic Oncology — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Since optimal treatment of uterine serous carcinoma remains unknown, novel therapeutic approaches need to be actively pursued. The molecular targets discussed warrant further investigation and suggest a potential role for therapeutic agents targeting HER-2 and EGFR, as well as downstream targets such as the PI3K-AKT-mTOR pathway in the treatment of uterine serous carcinoma. PMID: 20109727 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Breast cancer in cowden syndrome: manifestation of a familial cancer syndrome.

Clinical Journal of Oncology Nursing — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Erickson J, Lyon DE Cowden syndrome is a familial cancer predisposition syndrome associated with an increased risk for breast, thyroid, and endometrial cancers and benign manifestations. With early detection and appropriate therapeutic treatment, many of its associated tumors and cancers are treatable. By better understanding mutations such as Cowden syndrome, additional targeted therapies can be developed and delivered. PMID: 20118023 [PubMed - in process] (Source: Clinical Journal of Oncology Nursing)

The role of prostacyclin in lung cancer.

Translational Research : the journal of laboratory and clinical medicine — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Tennis MA, Vanscoyk M, Keith RL, Winn RA Prostanoids are bioactive lipids that interact with 7-membrane-spanning G-protein-coupled receptors on target cells to impart their biologic effects.(1) They include prostaglandins, prostacyclin, and thromboxane. Prostanoids are widely distributed; mediate several diverse biologic effects like platelet aggregation and smooth-muscle contraction; and are known to be involved in allergies, acquired immunity, and cancer metastasis.(2) Prostanoids have also been associated with breast and endometrial cancer promotion, and with the inhibition of melanoma. The role of prostanoids in the development of lung disease has been poorly understood. In particular, prostacyclin possesses significant anti-inflammatory and antimetastatic properties and i...

Robotic Surgery Works for Staging Endometrial Ca

Ob.Gyn. News — Mon, 01 Feb 2010 00:00:00 +0100

Major Finding: Robotic surgery was associated with significantly less blood loss and shorter hospital stays than laparotomy for the surgical staging of endometrial cancer. (Source: Ob.Gyn. News)

Intraoperative sentinel lymph node detection by vital dye through laparoscopy or laparotomy in early endometrial cancer

Journal of Surgical Oncology — Fri, 29 Jan 2010 00:00:00 +0100

Recent studies reported the feasibility of intraoperative lymphatic mapping in women with endometrial cancer but none of these studies compared the sentinel lymph nodes (SLNs) detection rates obtainable through laparoscopy or laparotomy. The purpose of this study was to address this issue.Thirty-four patients with clinical stage I-II endometrial cancer were enrolled in this prospective comparative trial. Four milliliters of Patent Blue Violet were injected into the cervix after the induction of general anesthesia. The assessment of SLNs was done in 17 patients through laparoscopy and in 17 patients through laparotomy as first step of systematic pelvic lymphadenectomy. Both SLNs and non-SLNs were evaluated for micrometastases.The SLNs detection rate was significantly higher (82%) for laparo...

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Laparoscopy Feasible and Safe in Older Women With Endometrial Cancer

Medscape Ob/Gyn & Women's Health Headlines — Thu, 28 Jan 2010 17:32:27 +0100

Laparoscopic surgery for endometrial cancer can be done safely in older women (>65 years), with immediate operative outcomes comparable to those in younger women, Italian researchers report. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)

Reports On Endometrial Cancer Findings Provide New Insights

Cancercompass News: Other Cancer — Thu, 28 Jan 2010 00:00:00 +0100

New research, 'Laparoscopic versus open surgery for endometrial cancer: a minimum 3-year follow- up study,' is the subject of a report. According to recent research from Varese, Italy, The paucity of long-term oncologic results published in the literature still prevents the scientific community from cementing the place of laparoscopy as the procedure of choice for managing endometrial cancer. (Source: Cancercompass News: Other Cancer)

Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes

Journal of Ovarian Research — Thu, 28 Jan 2010 00:00:00 +0100

Conclusion: Endometrioid ovarian cancer exhibits an alteration in the expression of IL-1RA, a key protector against tumorogenic effects of IL-1. This alteration evokes the same alteration observed in endometriotic cells in previous studies. This suggests a possible link between the endometrium, the tissue ectopic endometriosis and endometrioid ovarian cancer. (Source: Journal of Ovarian Research)

Data On Endometrial Cancer Discussed By Researchers At University Medical Center

Cancercompass News: Other Cancer — Thu, 28 Jan 2010 00:00:00 +0100

In this recently published article, scientists in Beer Sheva, Israel conducted a study To look for an association between the measles virus and endometrial carcinoma, the most frequent cancer of the female genital tract in our area. Thirty- six of 49 patients with endometrial carcinoma were studied to detect fingerprints of the measles virus. (Source: Cancercompass News: Other Cancer)

Epithelial-Stromal Interaction and Progesterone Receptors in the Mouse Uterus

Seminars in Reproductive Medicine — Wed, 27 Jan 2010 15:53:59 +0100

Semin Reprod Med 2010; 28: 027-035DOI: 10.1055/s-0029-1242990ABSTRACTHealthy uterine function depends on the balanced interaction of the ovarian steroids estrogen and progesterone (P4) signaling through their respective receptors. The expression of each receptor is regulated by the other through crucial cross talk between the epithelial and stromal compartments. Ablation of the progesterone receptor (PR) results in complete infertility in mice, and evidence increasingly demonstrates that the PR is a major mediator of epithelial-stromal cross talk and events leading to the disruption of this communication can lead to P4 resistance in the uterus. This resistance, through impaired P4 signaling, can be at the level of the PR itself, coregulators, and downstream effectors. The mechanisms underl...

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Role of Progesterone in Endometrial Cancer

Seminars in Reproductive Medicine — Wed, 27 Jan 2010 15:53:59 +0100

Semin Reprod Med 2010; 28: 081-090DOI: 10.1055/s-0029-1242998ABSTRACTProgesterone is a key hormone in the endometrium that opposes estrogen-driven growth. Insufficient progesterone will result in unopposed estrogen action that could lead to the development of endometrial hyperplasia and adenocarcinoma. Although these endometrial neoplasias can regress in response to progestin treatment, this does not occur in all instances. To understand this resistance to progesterone and to improve on existing hormonal therapies, it is imperative that the molecular mechanisms of progesterone action through its receptor be deciphered in endometrial cancer. This review highlights what is known thus far regarding the efficacy of progestin therapy in the clinic and the role of progesterone in endometrial can...

Lynch Syndrome--Related Endometrial Carcinomas Show a High Frequency of Nonendometrioid Types and of High FIGO Grade Endometrioid Types

International Journal of Surgical Pathology — Wed, 27 Jan 2010 06:50:28 +0100

Although endometrial cancer (EC) represents the second most common cancer after colonic cancer in patients with Lynch syndrome (LS), the pathologic features and behavior of LS-related EC are not well recognized. ECs from 23 patients (mean age 46.2 years) with MSH2 (16), MLH1 (6), and MLH1/MSH2 (1) constitutional mutations were evaluated for histologic type, FIGO grade, FIGO stage, association with tumors in other sites, and survival. For every LS-associated tumor, 2 same-age cases from patients with no family history of LS-associated cancer were evaluated (sporadic group). In LS-associated EC there were 13 (56.5%) endometrioid (eec) and 10 (43.5%) nonendometrioid carcinomas (neec), and among the sporadic tumors there were 44 (95.7%) eec and 2 (4.3%) neec (P = .001). The eec in women with g...

Management of drainage for malignant ascites in gynaecological cancer

NeLM - Oncology — Wed, 27 Jan 2010 00:00:00 +0100

Source: Cochrane Library Area: Evidence > Disease Focused Reviews Background Most patients with advanced ovarian cancer and some patients with advanced endometrial cancer need repeated drainage for malignant ascites. Guidelines to advise those involved in the drainage of ascites are usually produced locally and are generally not evidence-based but mainly based on clinicians' anecdotal evidence and experience. To discover whether there are ways of managing drains that have been demonstrated to improve the efficacy and quality of the procedure is key in making recommendations which could improve the quality of life (QOL) for women at this critical period of their lives. Objectives To evaluate the benefit and harms of different practices in the management of drains for mali...

The heterogeneity of epithelial ovarian cancer

Cancer — Wed, 27 Jan 2010 00:00:00 +0100

Epithelial ovarian cancer is heterogeneous and comprises 4 major rare subtypes - mucinous, clear cell, low-grade serous, and endometrioid - all distinct from the more common high-grade serous carcinoma. Women with uncommon histotypes should be triaged to separate clinical trials. (Source: Cancer)

Lymphadenectomy for endometrial cancer: The controversy.

Gynecologic Oncology — Wed, 27 Jan 2010 00:00:00 +0100

Authors: Seamon LG, Fowler JM, Cohn DE PMID: 20110120 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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HOXA10 Regulates Endometrial GABAA {pi} Receptor Expression and Membrane Translocation.

Am J Physiol Endocri... — Tue, 26 Jan 2010 00:00:00 +0100

Authors: Sadeghi H, Taylor HS Expression of the GABA(A) pi receptor has been previously described in the human endometrium in both luminal epithelium and stroma. Its expression is increased during decidualization in rodents and in the implantation window of human endometrium. Here we localized GABA pi subunit receptor protein in human endometrium and identified regulators of gene expression and activation. GABA(A) pi was localized to the cell surface and expression increased during the window of embryo implantation in human endometrium. The well-differentiated human endometrial adenocarcinoma cell line Ishikawa was treated with progesterone, transfected with pcDNA/HOXA10, HOXA10 siRNA or respective controls. GABA(A) pi receptor mRNA expression was evaluated by real time RT-PCR. Protein...

Endometrial Profile of Tamoxifen and Low-Dose Estradiol Combination Therapy.

Clinical Cancer Research — Tue, 26 Jan 2010 00:00:00 +0100

CONCLUSIONS: These findings characterize a novel phenotype resulting from estrogen + SERM co-therapy. The predominance of Tam effects on endometrial proliferation, morphology, and transcriptional profiles suggests that endometrial risks for E(2) + Tam may be similar to Tam alone. Clin Cancer Res; 16(3); 946-56. PMID: 20103679 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Relationship of atypical glandular cell cytology, age, and human papillomavirus detection to cervical and endometrial cancer risks.

Obstetrics and Gynecology — Mon, 25 Jan 2010 04:55:29 +0100

CONCLUSION:: High-risk HPV testing may distinguish between risk of endometrial cancer and cervical cancer in women with AGC cervical cytology, particularly in women aged 50 years or older. LEVEL OF EVIDENCE:: III. PMID: 20093895 [PubMed - in process] (Source: Obstetrics and Gynecology)

FGFR2 mutations are rare across histologic subtypes of ovarian cancer.

Gynecologic Oncology — Mon, 25 Jan 2010 00:00:00 +0100

CONCLUSIONS: Despite the low incidence of FGFR2 mutations in ovarian cancer, the two FGFR2 mutations identified in ovarian tumors (S252W, Y376C) overlap with the oncogenic mutations previously identified in endometrial tumors, suggesting activated FGFR2 may contribute to ovarian cancer pathogenesis in a small subset of ovarian tumors. PMID: 20106510 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

[Are there still contra-indications to laparoscopic treatment of endometrial carcinoma?]

Gynecologie, Obstetrique & Fertilite — Mon, 25 Jan 2010 00:00:00 +0100

Authors: Leblanc E, Samouelian V, Boulanger L, Narducci F Laparoscopic treatment is becoming a standard of care for early endometrial carcinoma. However, not all patients are suitable for this approach. A review of the current literature provides some arguments to differentiate absolute contra-indications from relative ones, for which, whenever possible, some options are suggested. PMID: 20106706 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)

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New Endometrial Cancer Research Published

Cancercompass News: Other Cancer — Fri, 22 Jan 2010 00:00:00 +0100

The objective of the study was to assess the association between tea consumption and endometrial cancer. Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles, investigators in Shanghai, People's Republic of China report. (Source: Cancercompass News: Other Cancer)

High Risk of Colorectal, Endometrial, and Lynch Syndrome Cancers for MSH6 Mutation Carriers

Gastroenterology — Fri, 22 Jan 2010 00:00:00 +0100

Persons carrying the germ-line MSH6 mutation are at high risk by 80 years of age for colorectal and endometrial cancers as well as any cancer associated with Lynch syndrome, according to a new study published online December 22, 2009 in the Journal of the National Cancer Institute. (Source: Gastroenterology)

F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2

BMC Cell Biology - Latest articles — Thu, 21 Jan 2010 00:00:00 +0100

Conclusions: Taken together, we have shown a novel mechanism whereby epithelial prostaglandin F2alpha-FP signaling regulates endothelial cell network formation and proliferation. In addition we provide novel in vitro evidence to suggest that prostaglandin F2alpha can directly regulate endothelial cell network formation but not endothelial cell proliferation. These findings have relevance for pathologies where the FP receptor is aberrantly expressed, such as endometrial adenocarcinoma, and provide in vitro evidence to suggest that targeting the FP receptor could provide an anti-angiogenic approach to reducing tumour vasculature and growth. (Source: BMC Cell Biology - Latest articles)

Ultrastaging of lymph node in uterine cancers

Journal of Experimental and Clinical Cancer Research — Thu, 21 Jan 2010 00:00:00 +0100

Conclusion: In uterine cancers, H&E, serial sectioning and IHC appears the best histological combined technique to detect micrometastases. Although accumulating data have proved the relation between the risk of recurrence and the presence of micrometastases, their clinical implications on indications for adjuvant therapy has to be clarified. (Source: Journal of Experimental and Clinical Cancer Research)

Novel Hydroxysteroid (17{beta}) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice.

The American Journal of Pathology — Thu, 21 Jan 2010 00:00:00 +0100

Authors: Saloniemi T, Järvensivu P, Koskimies P, Jokela H, Lamminen T, Ghaem-Maghami S, Dina R, Damdimopoulou P, Mäkelä S, Perheentupa A, Kujari H, Brosens J, Poutanen M Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly active estrone into highly potent estradiol. Here we report that female transgenic mice expressing human HSD17B1 invariably develop endometrial hyperplasia in adulthood. These mice also fail to ovulate and have enhanced peripheral conversion of estrone into estradiol in a variety of target tissues, including the uterus. As in humans, endometrial hyperplasia ...

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The association between metabolic abnormality and endometrial cancer: A large case-control study in China.

Gynecologic Oncology — Thu, 21 Jan 2010 00:00:00 +0100

CONCLUSIONS.: Our findings support the hypothesis that metabolic abnormalities or insulin resistance may promote the initiation and progression of endometrial cancer. The effective treatment of type 2 diabetes might contribute to endometrial cancer prevention. PMID: 20096921 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Tyrosine kinase expression in pulmonary metastases and paired primary tumors [Institutional report - Thoracic oncologic]

Interactive CardioVascular and Thoracic Surgery — Wed, 20 Jan 2010 23:13:41 +0100

Tyrosine kinase inhibitors against the receptors of vascular endothelial growth factor (VEGFR), epidermal growth factor (EGFR) and the platelet derived growth factor (PDGFR) are increasingly used in the treatment of progressive cancers. However, the expression of these receptors especially in lung metastases has not been examined. Tissue specimen from 35 lung metastases of 33 patients with renal cell carcinoma (n=8), sarcoma (n=10), colorectal carcinoma (n=6), otolaryngologic carcinoma (OLC, n=4), testicular and endometrial cancer (n=1 each), malignant melanoma (n=1), adrenal cancer (n=2), malignant fibrous histiocytoma and malignant peripheral nerve sheath tumor (n=1 each) have been immunohistochemically tested for the expression of PDGFR /β, VEGFR and EGFR. None of the patients had ...

A cancer stem cell origin for human endometrial carcinoma?

Reproduction — Wed, 20 Jan 2010 00:00:00 +0100

Authors: Hubbard S, Gargett C Endometrial cancer (EC) is the most common gynaecological malignancy affecting women in the Western world. Cancer stem cells (CSCs) are defined as a subset of tumour cells with the capacity to self renew and give rise to the differentiated cells that comprise the bulk of the tumour. Given that a rare population of epithelial stem/progenitor cells has been identified in human endometrium, it is possible that these or their progeny may be the source of the putative cancer stem cell that may initiate and maintain EC. Studies have shown that some cells within EC have the capacity to initiate clones that undergo self renewing cell division and form tumours in vivo that can be serially passaged, demonstrating self renewal, proliferation and differentiation abili...

Equine estrogen-induced mammary tumors in rats.

Toxicology Letters — Wed, 20 Jan 2010 00:00:00 +0100

Authors: Okamoto Y, Liu X, Suzuki N, Okamoto K, Kim HJ, Laxmi YR, Sayama K, Shibutani S Long-term hormone replacement therapy is associated with an increased risk of breast, ovarian and endometrial cancers in women. Equine estrogens are a principal component of hormone replacement therapy; however, their tumorigenic potential toward mammary tissue and reproductive organs has not been extensively explored. A pellet containing equilin was inserted under the skin of female ACI rats and the development of mammary tumors was monitored. Histological examination revealed premalignant lesions such as apocrine metaplasia in whole-mount preparations of mammary gland from the equilin-treated rats. ACI rats given 10mg equilin developed palpable mammary tumors at 13 weeks of treatment, and 37.5% of...

High risk for neoplastic transformation of endometriosis in a carrier of lynch syndrome

Familial Cancer — Tue, 19 Jan 2010 17:47:30 +0100

Abstract Lynch syndrome is an autosomal dominant cancer-susceptibility disorder caused by mutations in DNA mismatch repair genes. Women with Lynch syndrome have an increased lifetime risk for endometrial and ovarian cancers. While there is evidence of efficacy for prophylactic surgery, no standard recommendations have been developed to support screening for premalignant endometrial and ovarian epithelial lesions in high-risk women. Here, we report a case of a healthy woman carrying a germline mutation in MLH1 gene with endometrial intra-epithelial neoplasia and ovarian endometriotic lesions exhibiting a loss of MLH1 protein expression. This case report illustrates the malignant potential of endometriosis, and highlights the need for a meticulous management of gynecologic p...

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Differential sensitivity of human endometrial carcinoma cells with different PTEN expression to mitogen-activated protein kinase signaling inhibits and implications for therapy

Journal of Cancer Research and Clinical Oncology — Tue, 19 Jan 2010 17:42:14 +0100

Conclusions PTEN-deficient endometrial cancer cells exhibit higher p38MAPK activity, and genetic studies demonstrate that p38MAPK functions dependently of AKT. Furthermore, PTEN loss sensitizes cells to p38MAPK inhibition in endometrial carcinoma cells. These findings indicate that inhibitors of p38MAPK have the potential to be effective in the treatment of endometrial cancer patients with PTEN-deficient tumors and should be evaluated in this setting. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0756-4Authors Lan Xiao, Sun Yat-sen University Department of Obstetrics and Gynecology, The Third Affiliated Hospital 600 TianHe Road 510630 Guangzhou People’s Republic of ChinaYue-bo Yang, Sun Yat-sen University Department of Obstetrics and Gyn...

Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases

Journal of Experimental and Clinical Cancer Research — Tue, 19 Jan 2010 00:00:00 +0100

Conclusion: The present endometriosis model would be useful for investigation of the mechanisms of angiogenesis process involved in the peritoneal attachment of endometrial cells, as well as of the effects of therapeutic drugs, particularly with antiangiogenic activity. (Source: Journal of Experimental and Clinical Cancer Research)

Endometriosis-associated ovarian cancer: A ten-year cohort study of women living in the Estrie Region of Quebec, Canada

Journal of Ovarian Research — Tue, 19 Jan 2010 00:00:00 +0100

Conclusion: Our findings highlight that the number of cases of ovarian cancer is constantly increasing in the last ten years and that endometriosis represents a serious risk factor which accelerates its apparition by about 5.5 years. (Source: Journal of Ovarian Research)

Cochrane review: Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen

NeLM - Drug Specific Reviews — Tue, 19 Jan 2010 00:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Adjuvant tamoxifen reduces the risk of breast cancer recurrence in women with estrogen receptor-positive breast cancer. Tamoxifen also increases the risk of postmenopausal bleeding, endometrial hyperplasia, polyps, and endometrial cancer. The levonorgestrel-releasing intrauterine system (LNG-IUS) causes profound endometrial suppression. This systematic review considered the evidence that the LNG-IUS prevents the development of endometrial pathology in women taking tamoxifen as adjuvant endocrine therapy for breast cancer. Objectives To determine the effectiveness of the levonorgestrel intrauterine system in preventing the development of endometrial hyperplasia, polyps, and adenocarcinoma in pre and post...

Endometrial Cancer: Often Curable When Caught Early

Cancer / Oncology News From Medical News Today — Fri, 15 Jan 2010 10:00:00 +0100

Postmenopausal women who experience vaginal bleeding should see a doctor promptly. According to the January issue of Mayo Clinic Health Letter, vaginal bleeding is a symptom that occurs early in the course of endometrial cancer, when the chance of a complete cure is the greatest. Even one drop of blood is abnormal in postmenopausal women. The endometrium is the inner lining of the uterus... (Source: Cancer / Oncology News From Medical News Today)

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Endometrial Cancer: Often Curable When Caught Early

Health News from Medical News Today — Fri, 15 Jan 2010 10:00:00 +0100

Postmenopausal women who experience vaginal bleeding should see a doctor promptly. According to the January issue of Mayo Clinic Health Letter, vaginal bleeding is a symptom that occurs early in the course of endometrial cancer, when the chance of a complete cure is the greatest. Even one drop of blood is abnormal in postmenopausal women. The endometrium is the inner lining of the uterus. Endometrial cancer develops when cells divide and grow abnormally, potentially invading other layers of the uterine tissue or even spreading beyond the uterus... (Source: Health News from Medical News Today)

Researchers Report Details Of New Studies For Endometrial Cancer Immunology

Cancercompass News: Other Cancer — Fri, 15 Jan 2010 00:00:00 +0100

Investigators publish new data in the report 'p53 overexpression in morphologically ambiguous endometrial carcinomas correlates with adverse clinical outcomes.' According to a study from the United States, The distinction between uterine serous and endometrioid carcinomas can usually be achieved by morphologic examination alone. (Source: Cancercompass News: Other Cancer)

GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.

Clinical Cancer Research — Fri, 15 Jan 2010 00:00:00 +0100

CONCLUSION: These results suggest that GSK690693 or other Akt inhibitors might have therapeutic efficacy in human cancers with hyperactivated Akt and/or a dependence on Akt signaling for tumor progression. PMID: 20075391 [PubMed - in process] (Source: Clinical Cancer Research)

Stereotactic body radiotherapy for local boost irradiation in unfavourable locally recurrent gynaecological cancer

Radiotherapy and Oncology — Fri, 15 Jan 2010 00:00:00 +0100

Conclusion: Image-guided SBRT for local dose escalation resulted in high rates of local control but was associated with significant late toxicity. (Source: Radiotherapy and Oncology)

Endometrial Cancer: Often Curable When Caught Early

Mayo Clinic Health Information — Thu, 14 Jan 2010 18:18:17 +0100

According to the January issue of Mayo Clinic Health Letter, vaginal bleeding is a symptom that occurs early in the course of endometrial cancer, when the chance of a complete cure is the greatest. (Source: Mayo Clinic Health Information)

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Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer Phenotypes

Cancer Research — Thu, 14 Jan 2010 05:08:20 +0100

Microsatellite instability is associated with 10% to 15% of colorectal, endometrial, ovarian, and gastric cancers, and has long been used as a diagnostic tool for hereditary nonpolyposis colorectal carcinoma–related cancers. Tumor-specific length alterations within microsatellites are generally accepted to be a consequence of strand slippage events during DNA replication, which are uncorrected due to a defective postreplication mismatch repair (MMR) system. Mutations arising within microsatellites associated with critical target genes are believed to play a causative role in the evolution of MMR-defective tumors. In this review, we summarize current evidence of mutational biases within microsatellites arising as a consequence of intrinsic DNA sequence effects as well as variation in ...

Myocardin Functions as an Effective Inducer of Growth Arrest and Differentiation in Human Uterine Leiomyosarcoma Cells

Cancer Research — Thu, 14 Jan 2010 05:08:20 +0100

An unusual mechanism of cell cycle deregulation is revealed in uterine leiomyosarcomas, which along with endometrial tumors are the two most common uterine tumors encountered clinically. (Source: Cancer Research)

Long-Term Risk of Cancer High for Endometrial Hyperplasia

Modern Medicine — Thu, 14 Jan 2010 00:00:00 +0100

Women with endometrial hyperplasia are at much higher long-term risk of developing endometrial cancer if their hyperplasia is atypical, according to a study published online Jan. 11 in the Journal of Clinical Oncology. (Source: Modern Medicine)

Stereotactic body radiotherapy for local boost irradiation in unfavourable locally recurrent gynaecological cancer.

Wed, 13 Jan 2010 00:00:00 +0100

CONCLUSION: Image-guided SBRT for local dose escalation resulted in high rates of local control but was associated with significant late toxicity. PMID: 20079550 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms

European Journal of Cancer — Wed, 13 Jan 2010 00:00:00 +0100

Abstract: Sorafenib induces apoptosis and enhances Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced cell killing of tumoural cells. We have investigated the effects of the multikinase inhibitor Sorafenib alone or in combination with TRAIL and agonistic Fas antibodies on endometrial carcinoma cells. We have also focused on the search of the differential molecular mechanisms by which Sorafenib induces cell death and the ones involved in sensitisation to TRAIL. In the present study, we show that Sorafenib induces apoptosis of both endometrial cancer cell lines and human primary cultures and sensitises these cells to TRAIL and agonistic Fas antibodies (aFas)-induced apoptosis. However, Raf/MEK/ERK inhibition by Sorafenib was not responsible for Sorafenib cell death or T...

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Anti-breast cancer potential of SS1020, a novel antiestrogen lacking estrogenic and genotoxic actions

International Journal of Cancer — Wed, 13 Jan 2010 00:00:00 +0100

Long-term treatment with tamoxifen (TAM) increases the risk of developing endometrial cancer in women. Several antiestrogens developed in last decades have been discontinued from clinical testing because of their undesirable effects on the uterus. To avoid such serious side-effect while increasing the drug's anti-breast cancer potential, new triphenylethylene antiestrogens, 2E-3-{4-[(E)-4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]-phenyl} acrylic acid (SS1020) and 2E-3-{4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenyl}acrylic acid (SS1010), were designed as safer alternatives. Unlike TAM, SS1020 does not present significant uterotrophic potential in rats; in contrast, SS1010, a compound removing a 4-OH moiety from SS1020, represented weak uterotrophic activity. The structurally related co...

Reports Outline Endometrial Cancer Study Findings From R.W. Holloway And Colleagues

Cancercompass News: Other Cancer — Tue, 12 Jan 2010 00:00:00 +0100

In this recently published article, scientists in the United States conducted a study To provide an objective analysis of surgical performance of robotic-assisted laparoscopic hysterectomy (RALH) with lymphadenectomy for endometrial cancer during the learning phase of the procedure and to assess Opportunities for improvement. (Source: Cancercompass News: Other Cancer)

The effect of overweight and obesity on proliferation and activation of AKT and ERK in human endometria.

Gynecologic Oncology — Tue, 12 Jan 2010 00:00:00 +0100

CONCLUSION: These results show correlation between obesity (and overweight) and increased endometrial cell proliferation, and the activation of AKT and ERK1,2. These features could be related with the higher risk to develop type-I EC in overweight and obese women. PMID: 20074784 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway

Oncogene — Mon, 11 Jan 2010 00:00:00 +0100

Authors: S Murayama-Hosokawa, K Oda, S Nakagawa, S Ishikawa, S Yamamoto, K Shoji, Y Ikeda, Y Uehara, M Fukayama, F McCormick, T Yano, Y Taketani & H Aburatani (Source: Oncogene)

Germline Mutations and Polymorphisms in the Origins of Cancers in Women

Journal of Oncology — Sun, 10 Jan 2010 13:46:57 +0100

Several female malignancies including breast, ovarian, and endometrial cancers can be characterized based on known somatic and germline mutations. Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. The contributions of any single genetic variation or mutation in a population depend on its frequency and penetrance as well as tissue-specific functionality. Genome wide association studies, fluorescence in situ hybridization, comparative genomic hybridization, and candidate gene studies have enumerated genetic contributors to cancers in women. These include p53, BRCA1, BRCA2, STK11, PTEN, CHEK2, ATM, BRIP1, PALB2, FGFR2, TGFB1, MDM2, MDM4 as well as several other ...

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Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome

Familial Cancer — Fri, 08 Jan 2010 21:41:44 +0100

Abstract Lynch syndrome is an autosomal dominant cancer susceptibility syndrome characterized by the early development of microsatellite unstable colorectal, endometrial and other cancers. Lynch syndrome is caused by germline heterozygous loss-of-function sequence mutations within the mismatch repair genes MLH1, MSH2, MSH6 or PMS2. Some individuals with Lynch syndrome have constitutional epimutations, characterized by promoter methylation and transcriptional inactivation of a single allele in normal somatic tissues, while others lack identifiable pathogenic changes in the germline. We hypothesized that analysis of the relative levels of allelic expression of MLH1 would assist in the identification of cryptic pathogenic defects of MLH1 in five presumed Lynch syndrome cases wh...

Tea may prevent endometrial cancer, but needs study

Reuters: Health — Fri, 08 Jan 2010 21:40:40 +0100

TORONTO (Reuters Health) - Tea may protect against endometrial cancer, but more research is needed before it's clear if the antioxidant-rich beverage offers a real benefit, a recent analysis found. (Source: Reuters: Health)

IRS1 Regulation by Wnt/{beta}-Catenin Signaling and Varied Contribution of IRS1 to the Neoplastic Phenotype [Mechanisms Of Signal Transduction]

Journal of Biological Chemistry — Fri, 08 Jan 2010 14:36:09 +0100

Dysregulation of β-catenin levels and localization and constitutive activation of β-catenin/TCF (T cell factor)-regulated gene expression occur in many cancers, including the majority of colorectal carcinomas and a subset of ovarian endometrioid adenocarcinomas. Based on the results of microarray-based gene expression profiling we found the insulin receptor substrate 1 (IRS1) gene as one of the most highly up-regulated genes upon ectopic expression of a mutant, constitutively active form of β-catenin in the rat kidney epithelial cell line RK3E. We demonstrate expression of IRS1 can be directly activated by β-catenin, likely in part via β-catenin/TCF binding to TCF consensus binding elements located in the first intron and downstream of the IRS1 transcriptional star...

Endometrial Carcinoma with Extra-abdominal Metastasis: Improved Prognosis Following Cytoreductive Surgery

Annals of Surgical Oncology — Fri, 08 Jan 2010 09:15:51 +0100

Conclusions This is the first demonstration that aggressive cytoreductive surgery for stage IVb endometrial carcinoma with extra-abdominal metastasis has a beneficial role. However, further investigation is still required to establish better standard therapy for stage IVb endometrial cancer. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-009-0892-8Authors Yutaka Ueda, Osaka University Graduate School of Medicine Department of Obstetrics and Gynecology Osaka JapanTakayuki Enomoto, Osaka University Graduate School of Medicine Department of Obstetrics and Gynecology Osaka JapanTakashi Miyatake, Osaka University Graduate School of Medicine Department of Obstetrics and Gynecology Osaka JapanTomomi Egawa-Takata, Osaka University Graduate School ...