MedWorm: Endometrial Cancer

Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a case report.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

We report herein a first case of endometrial dedifferentiated endometrioid carcinoma in a 51-year old woman in Chinese population. We performed immunoperoxidase studies for 12 markers. Among them, cytokeratins, keratin 7, keratin 18, EMA, estrogen receptor (ER), progesterone receptor (PR), and vimentin show significantly differential expression between differentiated and undifferentiated area. PMID: 22295150 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

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Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells

Cancer Science — Tue, 07 Feb 2012 05:00:00 +0100

Endometrial cancer is the most common malignancy of the female genital tract and is associated with poor prognosis. It is primarily a hormone‐dependent cancer that is regulated by steroid hormones, including estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor in estrogen receptor (ER)‐positive breast cancer. In the present study, we investigated the expression of FOXA1 in endometrial cancers by immunohistochemical analysis. Nuclear immunoreactivity for FOXA1 was detected in 40 of 109 cases (37%), and was found to be negatively associated with lymph node status (P = 0.033). In ER‐positive Ishikawa endometrial cancer cells, small interfering RNA‐mediated downregulation of FOXA1 promoted cel...

Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: V Seebacher, S Polterauer, C Grimm, J Rahhal, G Hofstetter, E-M Bauer, H Husslein, H Leipold, C Marth, A Reinthaller & N Concin (Source: British Journal of Cancer AOP)

Illness perceptions in cancer survivors: what is the role of information provision?

Psycho-Oncology — Mon, 06 Feb 2012 05:00:00 +0100

ConclusionImproving the patients' illness perceptions by tailoring the information provision to the needs of patients may help patients to get a more coherent understanding of their illness and will possibly lead to a better health‐related quality of life. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Robotic Surgery: Ready for Prime Time in Endometrial Cancer?Robotic Surgery: Ready for Prime Time in Endometrial Cancer?

Medscape Today Headlines — Fri, 03 Feb 2012 21:20:17 +0100

Laparoscopic hysterectomy reduces complications and improves quality of life, but it is still not widely embraced, and the benefits of robotic surgery remain unclear. Medscape Medical News (Source: Medscape Today Headlines)

Efficacy and Safety of Testosterone in the Management of Hypoactive Sexual Desire Disorder in Postmenopausal Women

The Journal of Sexual Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusion. Transdermal testosterone appears to be an effective and safe therapy for postmenopausal women with HSDD. Davis SR and Braunstein GD. Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

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Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing

Modern Pathology AOP — Fri, 03 Feb 2012 05:00:00 +0100

Authors: Bojana Djordjevic, Bryan T Hennessy, Jie Li, Bedia A Barkoh, Rajyalakshmi Luthra, Gordon B Mills & Russell R Broaddus (Source: Modern Pathology AOP)

Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus

Endocrine — Thu, 02 Feb 2012 18:15:13 +0100

Abstract RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the steroidal regulation of uterine RECK is lacking. To address this gap in our knowledge, we examined steroidal regulation and cellular expression of Reck mRNA and protein within the mouse uterus in vivo. Uterine Reck mRNA and protein were decreased by estrogen, while progesterone alone had no effect. The estrogen-induced down regulation could be partially blocked by progesterone. RECK was localized primarily to luminal and glandular epithelial cells and the ...

[Lynch syndrome - epidemiology, clinical features, molecular genetics, screening, therapy].

Zeitschrift fur Gastroenterologie — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Schneider R, Fürst A, Möslein G Abstract Lynch syndrome is characterised by a familial predisposition of colorectal and endometrial carcinomas in association with a variety of other cancers. The underlying autosomal dominant inheritance has a penetrance of 85 - 90 %. The molecular genetic underlying mechanism is a mutation in one of the mismatch-repair genes. The identification of the molecular genetic basis of Lynch syndrome enabled the implementation of predictive testing in families with a proven mutation. A prerequisite to detect patients with Lynch syndrome is a knowledge of the clinical and histopathological features of this disease. Typical for Lynch syndrome associated carcinomas is the early age of onset of about 45 years as well as the characteristic localisa...

Vaginal relapse after laparoscopic hysterectomy in early endometrial carcinoma: does the intrauterine manipulator affect the results?

Gynecological Surgery — Mon, 30 Jan 2012 16:06:02 +0100

Content Type Journal ArticleCategory Case reportPages 1-3DOI 10.1007/s10397-012-0727-7Authors Santiago Domingo, Department of Obstetrics and Gynaecology, Hospital Universitario La Fe, Bulevar Sur, s/n, 46026 Valencia, SpainAlfredo Perales-Puchalt, Department of Obstetrics and Gynaecology, Hospital Universitario La Fe, Bulevar Sur, s/n, 46026 Valencia, SpainJose María Vila-Vives, Department of Obstetrics and Gynaecology, Hospital Universitario La Fe, Bulevar Sur, s/n, 46026 Valencia, SpainMarta Gurrea, Department of Obstetrics and Gynaecology, Hospital Universitario La Fe, Bulevar Sur, s/n, 46026 Valencia, SpainAntonio Pellicer, Department of Obstetrics and Gynaecology, Hospital Universitario La Fe, Bulevar Sur, s/n, 46026 Valencia, Spain Journal Gynecological SurgeryOnline ISSN...

Incidence rates of endometrial hyperplasia, endometrial cancer, and hysterectomy from 1980 to 2003 within a large prepaid health plan

International Journal of Cancer — Mon, 30 Jan 2012 05:00:00 +0100

AbstractObesity strongly increases risk of endometrial cancer and is projected to increase current and future endometrial cancer incidence. In order to fully understand endometrial cancer incidence, one should also examine both hysterectomy, which eliminates future risk of endometrial cancer, and endometrial hyperplasia (EH), a precursor that prompts treatment (including hysterectomy). Hysterectomy and EH are more common than endometrial cancer, but data on simultaneous temporal trends of EH, hysterectomy, and endometrial cancer are lacking. We used linked pathology, tumor registry, surgery, and administrative datasets at the Kaiser Permanente Northwest Health Plan to calculate age‐adjusted and age‐specific rates, 1980‐2003, of EH only (N=5990), EH plus hysterectomy (N=904), hysterec...

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Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study

Breast Cancer Research and Treatment — Fri, 27 Jan 2012 17:55:30 +0100

Abstract NEWEST (Neoadjuvant Endocrine Therapy for Women with Estrogen-Sensitive Tumors) is the first study to compare biological and clinical activity of fulvestrant 500 versus 250 mg in the neoadjuvant breast cancer setting. We hypothesized that fulvestrant 500 mg may be superior to 250 mg in blocking estrogen receptor (ER) signaling and growth. A multicenter, randomized, open-label, Phase II study was performed to compare fulvestrant 500 mg (500 mg/month plus 500 mg on day 14 of month 1) versus fulvestrant 250 mg/month for 16 weeks prior to surgery in postmenopausal women with ER+ locally advanced breast cancer. Core biopsies at baseline, week 4, and surgery were assessed for biomarker changes. Primary endpoint: change in Ki67 labe...

Immunohistochemical features of post‐radiation vaginal recurrences of endometrioid carcinomas of the endometrium: role for proteins involved in resistance to apoptosis and hypoxia

Histopathology — Fri, 27 Jan 2012 05:24:19 +0100

Conclusions: Genes involved in resistance to hypoxia are expressed in PVRs, and may play a role in the development of post‐radiation recurrences. (Source: Histopathology)

Loss of HLA class I and mismatch repair protein expression in sporadic endometrioid endometrial carcinomas

International Journal of Cancer — Fri, 27 Jan 2012 05:00:00 +0100

In conclusion, our results indicate that loss of MMR protein expression is related to selective downregulation of HLA class I which contributes to immune escape in EC with an abnormal MMR system. © 2012 Wiley‐Liss, Inc. (Source: International Journal of Cancer)

Laparoscopic Endometrial Cancer Staging: Fewer ComplicationsLaparoscopic Endometrial Cancer Staging: Fewer Complications

Medscape Medical News Headlines — Fri, 27 Jan 2012 03:24:40 +0100

Intraoperative complications are similar whether staging of endometrial cancer is done laparoscopically or by laparotomy. Reuters Health Information (Source: Medscape Medical News Headlines)

Liquid-based papanicolaou tests in endometrial carcinoma diagnosis: performance, error root cause analysis, and quality improvement.

American Journal of Clinical Pathology — Thu, 26 Jan 2012 22:55:58 +0100

Authors: Sams SB, Currens HS, Raab SS Abstract Recent reports show that the sensitivity of endometrial carcinoma detection on liquid-based Papanicolaou (Pap) tests (88%) is considerably higher than that reported on conventional Pap smears (20%-30%), although few laboratories have corroborated these results. We performed a 5-year retrospective review of all liquid-based Pap tests (n = 69) in women who later were given a diagnosis of endometrial carcinoma, performed error root cause analysis, and developed quality improvement initiatives as a means of error reduction. The original and rescreened Pap test sensitivity rates for endometrial carcinoma were 31.9% and 59.3%, respectively. Root cause analysis showed that poor specimen quality and cognitive failures contributed to a false-ne...

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Nodal Metastasis Risk in Endometrioid Endometrial Cancer.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:42:57 +0100

CONCLUSION:: Low-risk endometrioid uterine cancer criteria may be used to help guide treatment planning for reoperation in patients with incomplete surgical staging information. LEVEL OF EVIDENCE:: II. PMID: 22270280 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)

Endometrial cancer: potential treatment and prevention with progestin-containing intrauterine devices.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:35:36 +0100

Endometrial cancer: potential treatment and prevention with progestin-containing intrauterine devices. Obstet Gynecol. 2012 Feb;119(2 Pt 2):419-20 Authors: Leslie KK, Thiel KW, Yang S PMID: 22270423 [PubMed - in process] (Source: Obstetrics and Gynecology)

Progestin intrauterine device in an adolescent with grade 2 endometrial cancer.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:35:09 +0100

CONCLUSION: : A progestin-releasing IUD may be a valid treatment option for grade 2 endometrial cancer in young women who desire to retain fertility. PMID: 22270425 [PubMed - in process] (Source: Obstetrics and Gynecology)

Robotic-assisted laparoscopic transection and repair of an obturator nerve during pelvic lymphadenectomy for endometrial cancer.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:32:15 +0100

CONCLUSION: : Robotic-assisted laparoscopic repair is feasible for the treatment of obturator nerve injury. PMID: 22270439 [PubMed - in process] (Source: Obstetrics and Gynecology)

The Link Between Obesity and Endometrial CancerThe Link Between Obesity and Endometrial Cancer

Medscape Today Headlines — Thu, 26 Jan 2012 15:33:59 +0100

Strong biological support exists for a link between obesity and endometrial cancer, and the role of lifestyle change in prevention should not be ignored. Medscape Ob/Gyn (Source: Medscape Today Headlines)

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Robotic assisted surgery for gynaecological cancer.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: Well-designed RCTs are required as only low quality evidence from CCTs is available. These studies support the use of robotic assisted surgery for endometrial cancer and cervical cancer, but these findings present a high risk of bias. PMID: 22258988 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Evaluation of Depth of Myometrial Invasion and Overall Staging in Endometrial Cancer: Comparison of Diffusion-weighted and Dynamic Contrast-enhanced MR Imaging [Genitourinary Imaging]

Radiology — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion: DW MR imaging has superior diagnostic accuracy in the assessment of myometrial invasion and significantly higher staging accuracy compared with DCE MR imaging. © RSNA, 2011 (Source: Radiology)

Expression pattern of PAX2 in hyperplastic and malignant endometrium

Archives of Gynecology and Obstetrics — Tue, 24 Jan 2012 12:26:09 +0100

Conclusions PAX2 is expressed in hyperplastic and malignant endometrium as well as proliferative and atrophic endometrium. As the neoplastic lesion progresses from a premalignant state to endometrial cancer, PAX2 expression increases. These findings suggest that PAX2 may contribute to the development of endometrial cancer. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-6DOI 10.1007/s00404-012-2236-3Authors Korhan Kahraman, Department of Obstetrics and Gynecology, Ankara University School of Medicine, 06100 Ankara, TurkeySaba Kiremitci, Department of Pathology, Ankara University School of Medicine, Ankara, TurkeySalih Taskin, Department of Obstetrics and Gynecology, Ankara University School of Medicine, 06100 Ankara, TurkeyDuygu Kankaya, Department ...

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.

Cell Cycle — Tue, 24 Jan 2012 09:52:27 +0100

Authors: Walter G, Ruediger R Abstract Evidence that protein phosphatase 2A (PP2A) is a tumor suppressor in humans came from the discovery of mutations in the genes encoding the Aα and Aβ subunits of the PP2A trimeric holoenzymes, Aα-B-C and Aβ-B-C. One point mutation, Aα-E64D, was found in a human lung carcinoma. It renders Aα specifically defective in binding regulatory B' subunits. Recently, we reported a knock-in mouse expressing Aα-E64D and an Aα knockout mouse. The mutant mice showed a 50-60% increase in the incidence of lung cancer induced by benzopyrene. Importantly, PP2A's tumor suppressor activity depended on p53. These data provide the first direct evidence that PP2A is a tumor suppressor in mice. In addition, they suggest that PP2A is a tumor suppressor in human...

Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2

Journal of Cancer Research and Clinical Oncology — Tue, 24 Jan 2012 07:30:39 +0100

Conclusions Our data suggest that, for the endometrial cancer cell line RL95-2, GPR30 plays important roles in mediating the proliferative and invasive effects of estrogen and in tumorigenesis. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00432-011-1133-7Authors Yin-Yan He, Department of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaGui-Qiang Du, Department of Obstetrics and Gynecology, The International Peace Maternity and Child Health Hospital of the China Welfare Institute Affiliated to Shanghai Jiao Tong University, 910, Hengshan Road, Shanghai, ChinaBin Cai, Department of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shangh...

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DNA repair gene variants in endometrial carcinoma

Medical Oncology — Tue, 24 Jan 2012 06:54:26 +0100

In this study, we investigated the association of the polymorphisms in the DNA repair genes, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys, with endometrium cancer risk. Two hundred and sixty-two women were included in the study. Endometrial biopsy was performed, and on the basis of diagnosis and histological examination, women were divided into two groups: a control group (n = 158) and an endometrial cancer group (n = 104). Genotypes were determined by PCR–RFLP assays in endometrial carcinoma patients and age-matched controls. In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and ...

Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients

BMC Research Notes — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: A significant prognostic value of MSN and CLDN7 in predicting disease outcomes in patients with EC was not demonstrated. Nevertheless, the high percentage of EC cases with MSN and CLDN7 immunoexpression, and their association with tumor grade and subtypes, suggests that these proteins might play a role in tumorigenesis of endometrial adenocarcinomas. Future studies are needed to shed light on their mechanistic properties in EC cells. (Source: BMC Research Notes)

Pre-existing type-2 diabetes is not an adverse prognostic factor in patients with renal cell carcinoma: A single-center retrospective study.

Urologic Oncology — Tue, 24 Jan 2012 05:00:00 +0100

CONCLUSION: In our experience, the prevalence of DM in RCC patients is close to 10%. Such a condition does not determine any significant influence on prognosis of RCC. PMID: 22281433 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Ohio Medical Center deploys new cancer technology

Hospital Management — Tue, 24 Jan 2012 00:00:00 +0100

University Hospitals (UH) Case Medical Center in Ohio, US, has installed new technology at the Seidman Cancer Center to treat ovarian, endometrial and other cancers. (Source: Hospital Management)

Tissue-Specific Regulation of Genes by Estrogen Receptors

Seminars in Reproductive Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Semin Reprod Med 2012; 30: 14-22DOI: 10.1055/s-0031-1299593Estrogens are frequently used in reproductive medicine. The Women’s Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the benefits. The estrogens in MHT, however, were introduced prior to our understanding of the mechanism of action of estrogens. Estrogen signaling is highly complex, involving various DNA regulatory elements to which estrogen receptors bind. Numerous transcription factors and co-regulatory proteins modify chromatin structure to further regulate gene transcription. With a greater understanding of estrogen action, the major problem with the current estrogens in MHT appears to be that they are nonselective. This produces beneficial effects in bone, brain, and adipose tissue but ...

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A molecular carrier to transport and deliver cisplatin into endometrial cancer cells

Chemical Biology and Drug Design — Sat, 21 Jan 2012 19:13:08 +0100

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers.

Pathology Oncology Research — Sat, 21 Jan 2012 05:00:00 +0100

Authors: Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A, Brys M Abstract Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endo...

UH Case Medical Center offers new therapy for gynecologic cancer patients

EurekAlert! - Medicine and Health — Fri, 20 Jan 2012 05:00:00 +0100

(University Hospitals Case Medical Center) Patients with gynecologic cancer have new hope in a novel technology now offered at the Seidman Cancer Center at University Hospitals Case Medical Center. A team of cancer specialists, led by Robert DeBernardo, M.D., is among the first in the nation to launch a dedicated program using Hyperthermic Intraperitoneal Chemotherapy to treat ovarian, endometrial and select other cancers. (Source: EurekAlert! - Medicine and Health)

Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

Archives of Gynecology and Obstetrics — Thu, 19 Jan 2012 06:56:13 +0100

Conclusions Weight loss after the diagnosis and treatment of cancer may be an adverse prognostic factor. Although it was impossible to distinguish between intentional and non-intentional weight loss, these results argue against weight loss for risk reduction in patients with confirmed endometrial cancer. However, it may be reasonable regarding the risk reduction of non-cancer related morbidity and mortality. Detailed, prospective randomised trials are warranted. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-012-2224-7Authors Samer El-Safadi, Department of Obstetrics and Gynaecology, University Hospital Giessen and Marburg GmbH, Klinikstrasse 33, 35385 Giessen, GermanyAnna Sauerbier, Department of Obstetrics and Gynaecology, Un...

Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion: We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age. (Source: Journal of Cancer Research and Therapeutics)

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Loss of RKIP expression during the carcinogenic evolution of endometrial cancer

Journal of Clinical Pathology — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion This study demonstrated for the first time that RKIP expression is lost during the carcinogenic evolution of endometrial tumours and that the loss of RKIP expression is associated with a malignant phenotype. Functional studies are needed to address the biological role of RKIP downregulation in endometrial cancer. (Source: Journal of Clinical Pathology)

Therapeutic role of systematic retroperitoneal lymphadenectomy in endometrial cancer.

Bulletin du Cancer — Thu, 19 Jan 2012 05:00:00 +0100

Conclusions. Systematic retroperitoneal lymphadenectomy has a potentially therapeutic role on survival in surgically staged patients with endometrial cancer. PMID: 22266042 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

Gynecologic Cancer

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

Like many areas in oncology, gynecologic oncology has made several important recent advances in both the prevention and the treatment of reproductive malignancies. New knowledge related to risk factors for endometrial and ovarian cancer has led to novel strategies to reduce risks through diet, contraception choices, and other factors. Important advances have also occurred in the understanding of genetic risks for gynecologic cancers and genetic testing can now identify individuals at substantial risk. Patients at genetic risk can reduce their risk through the use of oral contraception and other choices if they have not completed their families or undergo definitive prophylactic surgery when they no longer desire future pregnancies. Cervical cancer is an area of particular advancement in pr...

Genetic Risk and Gynecologic Cancers

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

Hereditary cancer syndromes are responsible for 5% of endometrial cancers and 10% of ovarian cancers. Hereditary breast and ovarian cancer syndrome and Lynch syndrome account for most of these inherited cases. Significant advances have been made in the identification and management of women with these syndromes. In addition, recent advances have highlighted the prognostic and therapeutic implications for women with gynecologic cancers and inherited cancer syndromes. (Source: Hematology/Oncology Clinics of North America)

New Biologic Agents for the Treatment of Gynecologic Cancers

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

This article provides an update on the state of targeted therapy testing in gynecologic cancers. (Source: Hematology/Oncology Clinics of North America)

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Study linking HRT to breast cancer 'was wrong'

NHS News Feed — Tue, 17 Jan 2012 10:46:00 +0100

Conclusion Researchers have reanalysed the design and data from three studies that had suggested that HRT is associated with an increased risk that breast cancer would develop. They wanted to determine whether HRT caused breast cancer to develop (that the link was “causal”). The researchers looked at a pooled analysis study called the Collaborative Reanalysis, the Women’s Health Initiative randomised controlled trials and the Million Women Study, which was a large prospective cohort study including 800,000 post-menopausal women. The researchers found that these studies each failed to meet the majority of nine criteria which would be need to be met in order to say whether the studies could establish causality. These criteria included whether the women in the studies took HRT before th...

The impact of the genetic background on the genome make‐up of tumor cells

Genes, Chromosomes and Cancer — Tue, 17 Jan 2012 05:00:00 +0100

AbstractEndometrial adenocarcinoma (EAC) is the most common form of malignancy in the female genital tract, ranking as the fourth leading form of invasive tumors that affect women. The BDII inbred rat strain has been used as a powerful tumor model in studies of the genetic background of EAC. Females from the BDII strain are prone to develop tumors with an incidence of more than 90%. Development of EAC in BDII female rats has similarities in pathogenesis, histopathological, and molecular properties to that of human, and thus represents a unique model for analysis of EAC tumorigenesis and for comparative studies in human EACs. In a previous study, a set of rat EAC cell lines derived from tumors developed in female crossprogenies between BDII and nonsusceptible rat strains were analyzed by sp...

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma [Medical Sciences]

Proceedings of the National Academy of Sciences — Tue, 17 Jan 2012 05:00:00 +0100

We report a transforming 14-3-3 oncoprotein, which we identified through conventional cytogenetics and whole-transcriptome sequencing analysis as a highly recurrent genetic mechanism in a clinically aggressive form of uterine sarcoma: high-grade endometrial stromal sarcoma (ESS). The 14-3-3 oncoprotein results from a t(10;17) genomic rearrangement, leading to fusion between 14-3-3ε (YWHAE) and either of two nearly identical FAM22 family members (FAM22A or FAM22B). Expression of YWHAE–FAM22 fusion oncoproteins was demonstrated by immunoblot in t(10;17)-bearing frozen tumor and cell line samples. YWHAE–FAM22 fusion gene knockdowns were performed with shRNAs and siRNAs targeting various FAM22A exons in an t(10;17)-bearing ESS cell line (ESS1): Fusion protein expression was inhibited, wit...

Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

Gynecologic Oncology — Sat, 14 Jan 2012 05:00:00 +0100

CONCLUSIONS: Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. This combination may be a promising targeted therapy for endometrial cancer. PMID: 22252099 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Use of talcum powder and endometrial cancer risk

Cancer Causes and Control — Fri, 13 Jan 2012 16:48:37 +0100

Conclusions The absence of any increase in risk and the similarity of our results for talc use on the upper body and in the perineal area do not support the hypothesis that use of talc in the perineal area is associated with an increased risk of endometrial cancer. Our data do not confirm the positive association between perineal talc use and endometrial cancer observed in the only previous study. Content Type Journal ArticleCategory Brief reportPages 1-7DOI 10.1007/s10552-011-9894-5Authors Annette S. Neill, Genetics and Population Health Division, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, 4006 AustraliaChristina M. Nagle, Genetics and Population Health Division, Queensland Institute of Medical Research, 300 Herston Road, Hersto...

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A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular study and review of the literature.

World Journal of Surgical Oncology — Wed, 11 Jan 2012 05:00:00 +0100

Conclusion: With this report the authors have demonstrated that the spread of cervical adenocarcinoma to the uterine corpus, although rare, may be observed, and that in this instance immunohistochemical and molecular studies can provide sufficient information fo accurate diagnosis even on small biopsy specimens. (Source: World Journal of Surgical Oncology)

The metastasis‐associated gene MTA3 is an independent prognostic parameter in uterine non‐endometrioid carcinomas

Histopathology — Wed, 11 Jan 2012 05:00:00 +0100

(Source: Histopathology)

FIGO Staging System for Endometrial Cancer: Added Benefits of MR Imaging [Women's Imaging]

Radiographics recent issues — Wed, 11 Jan 2012 05:00:00 +0100

MR imaging assessment of endometrial cancer is discussed in terms of imaging protocol, recent modifications to the FIGO staging system, imaging appearances, and the complementary roles of diffusion-weighted and dynamic contrast-enhanced MR imaging. (Source: Radiographics recent issues)

Oncologic and Reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 Adenocarcinoma: A systematic review.

Gynecologic Oncology — Wed, 11 Jan 2012 05:00:00 +0100

CONCLUSION: Based on this systematic review of the contemporary literature, endometrial hyperplasia has a significantly higher likelihood of response (66%) to hormonal therapy than grade 1 endometrial carcinoma (48%). Disease persistence is more common in women with carcinoma (25%) compared to hyperplasia (14%). Reproductive outcomes do not seem to differ between the cohorts. PMID: 22245711 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Systemic therapy for advanced endometrial cancer.

Bulletin du Cancer — Tue, 10 Jan 2012 05:00:00 +0100

Authors: Tazi Y, Pautier P, Lhommé C Abstract Endometrial cancer has generally a good prognosis when it is diagnosed at an early stage but remains incurable at an advanced stage (recurrent or metastatic) with only few therapeutic options. Hormone therapy is the treatment of choice in case of slowly progressive disease with a tumor expressing hormonal receptors due to its favorable safety profile. Taxanes, anthracyclines and platinum compounds are the most active chemotherapy agents with greater response rates when they are combined at the price of a significant toxicity. Targeted therapies based on a better understanding of tumor biology are being evaluated with some promising results. PMID: 22236886 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

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Endometrial cancer: place for adjuvant chemotherapy.

Bulletin du Cancer — Tue, 10 Jan 2012 05:00:00 +0100

Authors: Lheureux S, Joly F Abstract Endometrial cancer is the most common gynaecological cancer in western countries. Radiotherapy remains the mainstay of postoperative management, but accumulating data show that adjuvant chemotherapy may display promising results after surgery. Characteristic features of the patients and disease, type of treatment including modality of surgery, radiation and chemotherapy are different from studies reported. The results from these trials are inconsistent but certain groups of patients with high-risk features could have advantage to adjuvant chemotherapy. The indication of adjuvant chemotherapy must be discussed in this situation taking into account the patient's profile with potential comorbidities and risk of toxicities. PMID: 22236833 [PubMe...

The quality of sexual life in women with gynaecological cancers

Archives of Gynecology and Obstetrics — Mon, 09 Jan 2012 19:35:21 +0100

Conclusions According to the results obtained from the study, it can be stated that the sexual quality of life of women with gynaecological cancers is moderate and social support, especially support from a significant person, may affect quality of sexual life positively. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-011-2210-5Authors Zehra Golbasi, Department of Nursing, Faculty of Health Sciences, Cumhuriyet University, Sivas, TurkeyAyten Senturk Erenel, Department of Nursing, Faculty of Health Sciences, Gazi University, Ankara, Turkey Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Lim1/LIM1 is expressed in developing and adult mouse and human endometrium

Histochemistry and Cell Biology — Mon, 09 Jan 2012 19:35:15 +0100

Abstract Lim1 encodes a homeodomain transcription factor required for head, kidney and female reproductive tract development in the murine embryo. Recently, Lim1 expression was documented in several adult murine and human organs. In the developing female reproductive tract, Lim1 expression was first detected in the Müllerian ducts. Using immunofluorescence, we detected LIM1 expression in a developmental model of human female reproductive tract which was established by recombination of neonatal uterine mesenchyme with human embryonic stem cells. In addition, we report a dynamic expression of Lim1/LIM1 in neonatal and adult mouse, and adult human endometrial epithelium and stroma as revealed by immunofluorescence and quantitative real-time polymerase chain reaction. LIM1 ex...

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas

Laboratory Investigation AOP — Mon, 09 Jan 2012 05:00:00 +0100

Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas Laboratory Investigation advance online publication, January 9, 2012. doi:10.1038/labinvest.2011.196 Authors: Makoto Saegusa, Miki Hashimura & Takeshi Kuwata (Source: Laboratory Investigation AOP)

Pathology of endometrioid carcinoma.

Bulletin du Cancer — Mon, 09 Jan 2012 05:00:00 +0100

This article describes anatomopathological and molecular features of this disease. Type I carcinoma, the most frequent, develops in a context of hyperoestrogenia. Endometrial glandular hyperplasia is the precursor lesion. The histological type is an endometrioid carcinoma. Its prognosis is good. Type II carcinoma is less frequent. It occurs on an atrophic mucosa. It is usually a more aggressive tumor like serous adenocarcinoma, clear cells carcinoma or carcinosarcoma with a poor prognosis. Type I and type II carcinoma also present different molecular pathways. PTEN inactivation, an early event in carcinogenesis, is the most frequent abnormality in type I carcinoma. An average of 28% of type I carcinoma also acquire PI3K mutations. On the contrary, P53 mutation is involved in 90% of type II...

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Postoperative vaginal brachytherapy in endometrial cancer.

Bulletin du Cancer — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Mazeron R, Khodari W, Gilmore J, Champoudry J, Dumas I, Morice P, Lhommé C, Haie-Méder C Abstract Several randomized studies published in recent years have greatly changed the management of postoperative endometrial cancer, especially for lesions of intermediate prognosis. Vaginal brachytherapy is now standard treatment for these lesions at the expense of external beam radiation, which, despite an improvement in locoregional control, has no impact on overall survival. This review aims to take stock of new indications for vaginal brachytherapy detailing the trials that led to change standards or care. PMID: 22231748 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

Proteomic analysis reflects different histologic subtypes of epithelial ovarian cancer

Medical Hypotheses — Mon, 09 Jan 2012 05:00:00 +0100

Abstract: Ovarian carcinoma is a significant cause of cancer mortality in women worldwide. As a heterogeneous disease, distinct clinical and molecular characteristics exist among different histologic subtypes. With the developments in proteomics, surfaced-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) is sensitive enough to detect minute quantity of proteins from serum or microdissected cryostat sections. Herein we hypothesized that differentially expressed protein profiles exist in ovarian carcinomas with distinct histologic subtypes. Compared with endometrioid carcinoma, two peaks were significantly higher in serous carcinoma with the m/z of 3622Da and 4778Da, reinforcing the need to treat different histologic subtypes of ovarian cancer as different ...

Outcome of investigations for postmenopausal vaginal bleeding in women under the age of 50years.

Gynecologic Oncology — Sun, 08 Jan 2012 05:00:00 +0100

CONCLUSIONS: We found no cases of endometrial cancer amongst 260 women presenting with postmenopausal vaginal bleeding under the age of 50years. These women could be investigated on a less urgent basis depending on the available resources. PMID: 22233690 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

Journal of Cancer Research and Clinical Oncology — Sat, 07 Jan 2012 16:56:16 +0100

Conclusions Loss of ING4 may promote microvessel formation and plays a role in facilitating the development of ovarian cancer. Although the specific mechanisms are not yet understood, our data suggest that ING4 may be a promising target for the treatment for ovarian cancer. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1099-5Authors Yinglan Liu, Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaLiqian Yu, Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaYingwei Wang, Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, ChinaYaling Zhang, Department of Obstetrics and Gynecolog...

LINE-1 hypomethylation in familial and sporadic cancer

Journal of Molecular Medicine — Sat, 07 Jan 2012 16:55:24 +0100

Abstract Increased and decreased methylation at specific sequences (hypermethylation and hypomethylation, respectively) is characteristic of tumor DNA compared to normal DNA and promotes carcinogenesis in multiple ways including genomic instability. Long interspersed element (LINE), an abundant class of retrotransposons, provides a surrogate marker for global hypomethylation. We developed methylation-specific multiplex ligation-dependent probe amplification assays to study LINE-1 methylation in cases of colorectal, gastric, and endometrial cancer (N = 276), stratified by patient category [sporadic; Lynch syndrome (LS); familial colorectal cancer type X (FCCX)] and microsatellite instability status. Within each patient group, LINE-1 showed lower methylation in tumor DNA ...

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MED12 mutations in uterine fibroids – their relationship to cytogenetic subgroups

International Journal of Cancer — Thu, 05 Jan 2012 05:00:00 +0100

AbstractRecurrent chromosomal alterations are found in roughly 20% of all uterine fibroids but in the majority cytogenetic changes are lacking. Recently, mutations of the gene mediator subcomplex 12 (MED12) have been detected in a majority of fibroids but no information is available whether or not they co‐occur with cytogenetic subtypes as e.g. rearrangements of the genes encoding high mobility group AT‐hook (HMGA) proteins. In a total of 80 cytogenetically characterized fibroids from 50 patients we were not only able to confirm the frequent occurrence of MED12 mutations but also to stratify two mutually exclusive pathways of leiomyomagenesis with either rearrangements of MED12 reflected by clonal chromosome abnormalities affecting 12q14∼15 or by mutations affecting exon 2 of MED12. ...

Isoflavones may reduce endometrial cancer risk

MedWire News - Oncology — Thu, 05 Jan 2012 00:00:00 +0100

High intake of isoflavone-containing foods may be associated with a reduced risk for endometrial cancer in postmenopausal women, US study data show. (Source: MedWire News - Oncology)

Systemic Sclerosis and Multiple Cancers of the Female Genital Tract: Prolonged Survival following Current Treatment Strategies

Clinical and Developmental Immunology — Wed, 04 Jan 2012 14:29:49 +0100

Conclusion. Although our patient was diagnosed at advanced stage disease, prolonged survival may be related with radical surgery and postoperative adjuvant chemotherapy according to current treatment strategies. (Source: Clinical and Developmental Immunology)

Legume, Soy, Tofu, and Isoflavone Intake and Endometrial Cancer Risk in Postmenopausal Women in the Multiethnic Cohort Study

JNCI — Tue, 03 Jan 2012 05:00:00 +0100

Conclusion This study suggests that greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of nonhysterectomized postmenopausal women. (Source: JNCI)

Fertility sparing management of endometrial adenocarcinoma and atypical hyperplasia: a literature review.

Bulletin du Cancer — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Koskas M, Yazbeck C, Walker F, Delorme P, Azria E, Luton D, Madelenat P Abstract In endometrial carcinoma (EC) and atypical hyperplasia (AH) diagnosed in childbearing years, the principle of uterine sparing consists in prescription of antigonadotropic treatment to obtain the remission of the endometrial lesion and allow pregnancy, always with a close follow-up looking for progression or persistence of the tumour. Studies evaluating this strategy have suggested the safety of such an approach, but numerous questions remain unanswered, like those concerning the type and the duration of treatment, and the systematic use of Assisted Reproductive Technologies… We performed a critical literature review in order to analyse patients and tumoral characteristics, treatment manageme...

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Radiation therapy versus chemoradiation as adjuvant treatment in high-risk endometrial cancer.

Bulletin du Cancer — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Fumagalli I, Leblanc E, Nickers P Abstract Endometrial cancer is a common malignancy. Management of these tumors depends on several risk factors such as FIGO staging, myometrial invasion, histology or pelvic lymph node involvement. According to those factors, low risk, intermediate and high risk groups were defined. A high risk endometrial cancer has a poorer prognostic and more risks of recurrence. Treatment of such disease should be more agressive. However modalities of these treatments have not yet been clearly defined. PMID: 22212613 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

Endometrial Stromal Polyps in Rodents: Biology, Etiology and Relevance to Disease in Women.

Toxicologic Pathology — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Davis B Abstract Endometrial stromal polyps (ESP) are a common spontaneous reproductive tract lesion in the female rat. However, there is limited information concerning the etiology, biology, and significance of these polyps as an end point in toxicology and carcinogenicity studies. This paper reviews relevant literature to address these aspects of ESP with respect to potential relevance to human uterine tumors. Endometrial stromal polyps in rodents appear as age-related lesions. There are only a few chemicals tested for carcinogenicity in rat and mouse cancer bioassays associated with increased incidence of ESP with no common characteristics or mechanism of action. Uterine endometrial polyps that occur in women and the uterine stromal polyps that occur in rodents have dis...

Collision of three histologically distinct endometrial cancers of the uterus.

J Korean Med Sci — Sun, 01 Jan 2012 05:00:00 +0100

We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed müllerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcinoma component invaded the underlying myometrium and metastasized to the regional lymph node. Adjuvant chemotherapy and radiation therapy were performed. The patient is sti...

Study Supports Hysteroscopy to Diagnose Endometrial Ca

Ob.Gyn. News — Sun, 01 Jan 2012 05:00:00 +0100

Major Finding: Hysteroscopy for the diagnosis of endometrial cancer was associated with 94% sensitivity, 98% specificity, a 73% positive predictive value, and a 99.6% negative predictive value. (Source: Ob.Gyn. News)

Nuclear features in endometrial cytology: Comparison of endometrial glandular and stromal breakdown and endometrioid adenocarcinoma grade 1

Diagnostic Cytopathology — Sun, 01 Jan 2012 05:00:00 +0100

This study was to clarify the nuclear features of “condensed clusters of stromal cells (EGBD‐stromal cells)” and “metaplastic clumps with irregular protrusions (EGBD‐metaplastic cells)” which may be recognized in endometrial glandular and stromal breakdown (EGBD) cases in liquid‐based cytologic (LBC) preparations of endometrial brushings. The material consists of cytologic smears of 20 cases of proliferative endometrium (PE), 20 cases of EGBD, and 20 cases of endometrioid adenocarcinoma grade 1 (G1) for which histopathological diagnosis was obtained by endometrial curettage. Nuclear findings were examined in PE cells, EGBD‐stromal cells, EGBD‐metaplastic cells, and G1 cells, respectively.It was examined about the following items: (1) Nuclear shape; (2) A long/minor axis r...

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Evaluation and management of abnormal uterine bleeding in premenopausal women.

American Family Physician — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Sweet MG, Schmidt-Dalton TA, Weiss PM, Madsen KP Abstract Up to 14 percent of women experience irregular or excessively heavy menstrual bleeding. This abnormal uterine bleeding generally can be divided into anovulatory and ovulatory patterns. Chronic anovulation can lead to irregular bleeding, prolonged unopposed estrogen stimulation of the endometrium, and increased risk of endometrial cancer. Causes include polycystic ovary syndrome, uncontrolled diabetes mellitus, thyroid dysfunction, hyperprolactinemia, and use of antipsychotics or antiepileptics. Women 35 years or older with recurrent anovulation, women younger than 35 years with risk factors for endometrial cancer, and women with excessive bleeding unresponsive to medical therapy should undergo endometrial biopsy. Tr...

HMGA2 is commonly expressed in uterine serous carcinomas and is a useful adjunct to diagnosis

Histopathology — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Immunoreactivity for HMGA2 is diffusely positive in whole tissue sections in most uterine serous carcinomas and negative in most endometrioid carcinomas, although, as with other markers, there is overlap in individual cases. In conjunction with other markers, HMGA2 may be of value in problematic uterine carcinomas where the differential diagnosis includes serous and endometrioid carcinoma. As HMGA2 is expressed in serous EIC, this suggests that it may be implicated in the early development of uterine serous carcinoma. (Source: Histopathology)

American Brachytherapy Society consensus guidelines for adjuvant vaginal cuff brachytherapy after hysterectomy

Brachytherapy — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Recommendations are made for adjuvant vaginal cuff brachytherapy. Practitioners and cooperative groups are encouraged to use these recommendations to formulate their treatment and dose reporting policies. These recommendations will permit meaningful comparisons of reports from different institutions and lead to better and more appropriate use of vaginal brachytherapy. (Source: Brachytherapy)

American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer

Brachytherapy — Sun, 01 Jan 2012 05:00:00 +0100

Conclusion: Recommendations are made for interstitial brachytherapy for vaginal cancer and recurrent disease in the vagina. Practitioners and cooperative groups are encouraged to use these recommendations to formulate treatment and dose-reporting policies. Such a process will result in meaningful outcome comparisons, promote technical advances, and lead to appropriate utilization of these techniques. (Source: Brachytherapy)

[Physiologic and molecular mechanisms linking physical activity to cancer risk and progression].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Ulrich CM, Wiskemann J, Steindorf K Abstract Physical activity is associated with a reduced risk of colon, breast, endometrial, lung, and pancreatic cancer. Evidence for mediating molecular mechanisms from experimental studies substantially strengthens the causal inference for this relationship. Randomized controlled trials indicate that exercise affects metabolic profiles, including hormone levels (estrogen, insulin signaling), inflammation (e.g., C-reactive protein), and adipokine concentrations (e.g., leptin). The size of the effect depends frequently on concurrent changes in body composition. There is also initial evidence for effects on immune function, oxidative stress, and possibly DNA repair capacity. Finally, outdoor physical activity can directly increase 25(OH)-...

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Personalized therapy in endometrial cancer: Challenges and opportunities.

Cancer Biology and Therapy — Fri, 30 Dec 2011 12:06:21 +0100

Authors: Westin SN, Broaddus RR Abstract Early stage endometrial cancer is generally curable. However, progress in the treatment of advanced and recurrent endometrial cancer has been limited. This has led to a shift from the use of traditional chemotherapeutic agents and radiotherapy regimens to the promising area of targeted therapy, given the large number of druggable molecular alterations found in endometrial cancer. To maximize the effects of directed targeted therapy, careful molecular characterization of the endometrial tumor is necessary. This represents an important difference in the use of targeted therapy versus traditional chemotherapy or radiation treatment. This review will discuss relevant pathways to target in endometrial cancer as well as the challenges which arise ...

Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach.

Molecular Medicine — Thu, 29 Dec 2011 07:24:03 +0100

Authors: Pavicic W, Perkiö E, Kaur S, Peltomäki P Abstract MicroRNAs (miRNAs) are small noncoding RNAs that contribute to tumorigenesis by acting as oncogenes or tumor suppressor genes and may be important in the diagnosis, prognosis and treatment of cancer. Many miRNA genes have associated CpG islands, suggesting epigenetic regulation of their expression. Compared with sporadic cancers, the role of miRNAs in hereditary or familial cancer is poorly understood. We investigated 96 colorectal carcinomas, 58 gastric carcinomas and 41 endometrial carcinomas, occurring as part of inherited DNA mismatch repair (MMR) deficiency (Lynch syndrome), familial colorectal carcinoma without MMR gene mutations or sporadically. Methylation-specific multiplex ligation-dependent probe amplification ...

Laparoscopic Surgery for Endometrial Cancer: Why Don’t All Patients Go Home the Day After Surgery?

The Journal of Minimally Invasive Gynecology — Wed, 28 Dec 2011 19:53:00 +0100

Conclusions: Laparoscopic surgery to treat endometrial cancer should be preferentially scheduled early in the day to facilitate discharge on POD1. The extent of staging lymphadenectomy performed does not increase hospital stay beyond POD1. (Source: The Journal of Minimally Invasive Gynecology)

Uterine Cancer

Springer Medicine titles — Wed, 28 Dec 2011 12:07:16 +0100

Screening, Diagnosis, and Treatmentseries:Current Clinical OncologyThere are an estimated 41,000 new cases of Uterine and Endometrial Cancer each year in the United States alone, resulting in roughly 7300 deaths. In Uterine Cancer: Screening, Diagnosis and Treatment, Franco Muggia, Esther Oliva and a panel of prominent medical and gynecologic oncologists survey all aspects of Uterine and Endometrial Cancer, including current screening methods, staging and ... (Source: Springer Medicine titles)

Endometrial cancers and predisposition.

Bulletin du Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Caron O Abstract As nearly 5% of all endometrial cancers occur because of a predisposition, this possibility has systematically to be explored. The hallmarks of predisposition, a young age at diagnosis, a personal or a familial history of cancer, have to be searched systematically. The identification of a predisposition in a family has a major impact on the management of the proband or his relatives. The endometrial cancer main predisposition is Lynch's syndrome. In this review, we will focus on this condition and describe its clinical manifestations, the underlying molecular mechanisms, the cancer risks and the management guidelines. We will also get onto some far less frequent other predispositions. PMID: 22198465 [PubMed - as supplied by publisher] (Source: Bulletin...

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Ovarian preservation during treatment of early stage endometrial cancer.

Bulletin du Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Poilblanc M, Samouelian V, Querleu D Abstract Endometrial cancer staging is based on surgery. No matter the age of the patient, the surgical staging includes at least a total hysterectomy with bilateral salpingo-oophorectomy. Twenty to 25% of the patients diagnosed with endometrial cancer are younger than 45 years. Although some discrepancies among series may be observed, in this population, endometrial cancers are mainly of lower grade, confined to the uterus (without ovarian involvement) and of better prognosis compared to older patients. The impact of premature menopause on the quality of life, cardiovascular and bone systems should not be neglected. This raises the issue of the systematic bilateral oophorectomy legitimacy while staging endometrial cancer staging in y...

Advanced endometrial carcinoma: primary debulking surgery or neoadjuvant chemotherapy?

Bulletin du Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Guyon F, Stoeckle E, Thomas L, Petit A, Sire M, Floquet A Abstract Endometrial cancers with peritoneal spread are stage IVB of FIGO classification. Their pattern is similar to that of ovarian cancer. Optimal debulking surgery and chemotherapy are predictor of better overall and disease free survival. Despite the poor outcome, there is a need for new treatment options. Recommended management for this group of patients should consist of surgical cytoreduction followed by chemotherapy. There may be a role for neoadjuvant chemotherapy followed by interval surgery in selected subgroups of patients. PMID: 22198346 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

Sentinel node procedure and endometrial cancer: senti-endo results.

Bulletin du Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Daraï E, Zacharopoulou C, Touboul C, Chéreau E, Ballester M Abstract Based on two randomized trials and a meta-analysis, the recommendations of the National Cancer Institute (INCa) have validated the absence of systematic pelvic lymphadenectomy for patients with endometrial cancer at low risk (type 1 histology stage IA grade 1-2) and intermediate (type 1 histology stage IA grade 3 and IB grade 1-2) but without taking into account the contribution of the sentinel node (SN) procedure. The senti-endo trial assessing the role of the SN procedure in patients with early stages endometrial cancer showed that the detection rate by hemi-pelvis right and left were 77 and 76%, respectively. The detection rate per patient was 89%. Among patients with at least a SN detected, the dete...

International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency

Journal of Allergy and Clinical Immunology — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: A consensus for the management of female patients with HAE-C1-INH is presented. (Source: Journal of Allergy and Clinical Immunology)

Comparison of laparoscopy and laparotomy for endometrial cancer

International Journal of Gynaecology and Obstetrics — Mon, 26 Dec 2011 05:00:00 +0100

Abstract: Objective: To compare the safety and efficacy of laparoscopy and laparotomy on clinical outcomes among patients with endometrial cancer.Methods: Eligible randomized controlled trials (RCTs) conducted between 1966 and June 2010 were analyzed by meta-analysis.Results: Eight RCTs were included, with 3599 patients in total. No significant difference was observed between laparoscopy and laparotomy in overall (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.50–1.82; P=0.892), disease-free (OR, 0.96; 95% CI, 0.50–1.82; P=0.892), or cancer-related (OR, 0.90; 95% CI, 0.27–3.08; P=0.871) survival. More intraoperative complications (OR, 1.33; 95% CI, 1.03–1.73; P=0.030), fewer postoperative complications (OR, 0.59; 95% CI, 0.46–0.75; P (Source: International Journal of Gyna...

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Generation and characterization of orthotopic murine models for endometrial cancer

Clinical and Experimental Metastasis — Sat, 24 Dec 2011 16:45:43 +0100

We describe the generation of two orthotopic murine models for endometrial cancer (EC).The first model is generated from endometrial Hec-1A cancer cells transfected with luciferase and injected directly into the uterus of female mice. This model allows a follow-up with bioluminescence imaging (BLI) along the experiment and generates abdominal dissemination and lymphatic and hematogenous metastases in high percentages, also detectables with BLI. The dissemination pattern of this model imitates the advanced stages of EC in patients, and its molecular profile corresponds to aggressive type 2 EC (p53 positive, hormone receptors negative, high percentage of Ki67 positive cells). The second model is derived from endometrioid human tissue collected from surgical pieces. By injecting this ti...

Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma

Modern Pathology AOP — Fri, 23 Dec 2011 05:00:00 +0100

Authors: Robert A Soslow, Guangming Han, Kay J Park, Karuna Garg, Narciso Olvera, David R Spriggs, Noah D Kauff & Douglas A Levine (Source: Modern Pathology AOP)

Current therapy of patients with endometrial carcinoma

Strahlentherapie und Onkologie — Thu, 22 Dec 2011 06:44:29 +0100

Abstract Magnetic resonance imaging (MRI), 18-FDG positron emission tomography (18FDG PET-CT), and computed tomography (CT) have demonstrated disappointing detectability of lymph node metastases in endometrial cancer. The treatment of choice in patients with endometrial cancer is hysterectomy and bilateral salpingoophorectomy. Above all, obese patients with comorbidity have benefited the most from laparoscopically assisted approaches. For inoperable patients in FIGO stage I/II, radiation remains an alternative to hysterectomy. The role of pelvic and paraaortic lymphadenectomy is the most controversial issue in endometrial carcinoma treatment. The current spectrum of treatment ranges from no lymphadenectomy, exclusive pelvic or additional inframesentric paraaortic sampl...

Sonohysterography: The Utility of Diagnostic Criteria Sets

American Journal of Roentgenology — Thu, 22 Dec 2011 05:00:00 +0100

CONCLUSION. The application of standardized diagnostic criteria may enhance the diagnostic accuracy of sonohysterography. (Source: American Journal of Roentgenology)

Intraoperative Microwave Ablation of Pulmonary Malignancies with Tumor Permittivity Feedback Control: Ablation and Resection Study in 10 Consecutive Patients [Vascular and Interventional Radiology]

Radiology — Wed, 21 Dec 2011 05:00:00 +0100

Conclusion: MWA with tumor permittivity feedback control results in cytotoxic intratumoral temperatures and extension of ablation zones into aerated peritumoral pulmonary parenchyma, possibly forming the equivalent of an oncologic resection margin. © RSNA, 2011 (Source: Radiology)

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Hormone may ease menopause symptoms

NHS News Feed — Tue, 20 Dec 2011 18:00:00 +0100

Conclusion This small, randomised controlled trial found that both menopause symptoms and measures of sexual function could be improved by three types of hormone therapy. The study compared a form of HRT, tibolone (a unique drug with oestrogen, progestogen and male hormone activity) and another type of hormone therapy called DHEA, which is not currently licensed for use in the UK. One group of women received vitamin D but no hormone therapies. The study was small, including 48 women in total and 12 in each group. This means there is a higher likelihood the findings are due to chance. Additionally, although the women saw improvements in sexual function, they had normal sexual function at the start of the study and did not have a clinical diagnosis of sexual dysfunction. It is not known whet...

Temsirolimus in combination with carboplatin and paclitaxel in patients with advanced solid tumors: a NCIC-CTG, phase I, open-label dose-escalation study (IND 179)

Annals of Oncology — Tue, 20 Dec 2011 05:00:00 +0100

Conclusion: Carboplatin–paclitaxel–temsirolimus is well tolerated and the RPTD is carboplatin area under the curve 5 mg/ml/min, paclitaxel 175 mg/m2, both given on day 1 with temsirolimus 25 mg on days 1 and 8. (Source: Annals of Oncology)

Coffee drinking and risk of endometrial cancer: Findings from a large up‐to‐date meta‐analysis

International Journal of Cancer — Tue, 20 Dec 2011 05:00:00 +0100

In conclusion, our findings suggest that increased coffee intake is associated with a reduced risk of endometrial cancer, consistently observed for cohort and case‐control studies. More large studies are needed to determine subgroups to obtain more benefits from coffee drinking in relation to endometrial cancer risk. (Source: International Journal of Cancer)

The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Tue, 20 Dec 2011 05:00:00 +0100

Conclusions: Malignant mixed műllerian tumour is characterised by a high incidence of lymph node metastases and advanced stage at diagnosis, leading to poorer overall survival than other subtypes of endometrial carcinoma. Clinical trials for MMMT are critical for improving treatment strategies. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Surgical approaches for endometrial cancer?

Bulletin du Cancer — Tue, 20 Dec 2011 05:00:00 +0100

Authors: Narducci F, Jean-Laurent M, Lambaudie E, Coutty N, Leblanc E Abstract The recommendations of the Institut national du cancer and of the Société francaise d'oncologie gynécologique in endometrial carcinoma (2010) reported that laparoscopy is the standard surgical approach for patients with apparent stage FIGO I in preoperative outcomes including MRI (www.e-cancer.fr). For patients with stage FIGO greater than I, laparotomy is the standard surgical approach. In case of lymph nodes or peritoneal restaging, the laparoscopy could be a good option especially by extraperitoneal route in patients with recent first surgery. PMID: 22192868 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

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Coffee consumption and risk of endometrial cancer: Findings from a large up‐to‐date meta‐analysis

International Journal of Cancer — Tue, 20 Dec 2011 05:00:00 +0100

In conclusion, our findings suggest that increased coffee intake is associated with a reduced risk of endometrial cancer, consistently observed for cohort and case–control studies. More large studies are needed to determine subgroups to obtain more benefits from coffee drinking in relation to endometrial cancer risk. (Source: International Journal of Cancer)

A case of serous endometrial intraepithelial carcinoma with p53 positivity for six years

Journal of Obstetrics and Gynaecology Research — Mon, 19 Dec 2011 05:00:00 +0100

AbstractA 69‐year‐old postmenopausal woman was referred because she had been taking tamoxifen for four years. Tissues obtained by endometrial curettage were immunopositive for p53, but there was no definite malignancy. At age 73, cytology again showed abnormalities, so we repeated complete endometrial curettage. Again, there was no malignancy, but p53 immunostaining was widely positive. At age 75, hysterectomy was performed because cytological examination showed increasingly abnormal findings and the patient opted for surgery. In the resected uterus, endometrial glands were replaced by malignant cells resembling papillary serous carcinoma cells with high‐grade nuclei, but there was no stromal or myometrial invasion. The pathological diagnosis was intraepithelial serous endometrial ca...

Strategies for Distinguishing Low-grade Endometrioid and Serous Carcinomas of Endometrium

Advances in Anatomic Pathology — Fri, 16 Dec 2011 17:50:17 +0100

Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are occasional problematic cases. This review focuses on strategies that help differentiate between low-grade endometrioid carcinoma and serous carcinoma of the endometrium. We will discuss clinical, morphologic, and immunohistochemical differences between the 2 entities and provide practical tips for practicing pathologists when confronted with this differential diagnosis. (Source: Advances in Anatomic Pathology)

French recommendations for endometrial cancer 2010: clinical use and questions still debated.

Bulletin du Cancer — Fri, 16 Dec 2011 05:00:00 +0100

Authors: Uzan C, Gouy S, Pautier P, Lhommé C, Duvillard P, Haie-Meder C, Morice P Abstract Most of patients with endometrial cancer are diagnosed at an early stage and therapeutics should be more limited in order to decrease morbidity. New French recommendations have been published in 2010, integrating this objective of therapeutic de-escalation. This review presents the take home messages of these recommendations (pretherapeutic staging, new FIGO staging and its criticism, evolution of surgical treatment more limited for low risk patients, management of specific histology, postoperative treatment, follow up) and the possible difficulties in the daily use of these recommendations. Indeed, the current recommended management for endometrial cancer is more complex but the ultimate go...

FDG-PET and endometrial cancer.

Bulletin du Cancer — Fri, 16 Dec 2011 05:00:00 +0100

This article is an update of the literature data to enable everyone to form an opinion on the subject. Future prospects are considered. PMID: 22182739 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)

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Dosimetric Comparison of Combined Intensity-Modulated Radiotherapy (IMRT) and Proton Therapy Versus IMRT Alone for Pelvic and Para-Aortic Radiotherapy in Gynecologic Malignancies

International Journal of Radiation Oncology * Biology * Physics — Fri, 16 Dec 2011 05:00:00 +0100

Conclusions: Compared with IMRT alone, PSPT/IMRT and IMPT/IMRT had a statistically significant decrease in dose to the small and large bowel and kidneys, while maintaining excellent planning target volume coverage. Further studies should be done to correlate the clinical significance of these findings. (Source: International Journal of Radiation Oncology * Biology * Physics)

Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades.

Gynecologic Oncology — Thu, 15 Dec 2011 05:00:00 +0100

CONCLUSIONS: Increased adrenomedullin expression may result in amplifying both tumorigenic and angiogenic activities. A substantial impact on growth of tumours may result in vivo as a consequence of the synergism between adrenomedullin and VEGF. Adrenomedullin, which has altered cellular characteristics in tumour compared to healthy tissue, offers an understudied target with potential to modify endometrial cancer behaviour, complementing other treatments. PMID: 22178239 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas

Histopathology — Wed, 14 Dec 2011 05:00:00 +0100

(Source: Histopathology)

Study Finds Coffee May Lower Risk of Endometrial Cancer

MedlinePlus Health News — Tue, 13 Dec 2011 17:09:17 +0100

Source: American Cancer Society Related MedlinePlus Page: Uterine Cancer (Source: MedlinePlus Health News)

Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

Clinical Cancer Research — Tue, 13 Dec 2011 05:00:00 +0100

CONCLUSIONS: Visceral adipose contains a population of multipotent MSC that promote endometrial tumor growth more potently than MSC from subcutaneous adipose tissue. We propose that O-ASC recruited to tumors express specific factors that enhance tumor vascularization and promote survival and proliferation of tumor cells. PMID: 22167410 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Vital Signs: Four Daily Cups of Coffee May Cut Cancer Risk in Women

NYT — Tue, 13 Dec 2011 04:07:33 +0100

Women who drank four or more cups of coffee a day are at reduced risk of endometrial cancer, a large new study found. (Source: NYT)

Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project

International Journal of Epidemiology — Fri, 09 Dec 2011 05:00:00 +0100

Conclusion There was no overall association between MetS and ovarian cancer risk. However, increasing levels of cholesterol and blood pressure increased the risks of mucinous and endometrioid tumours, respectively. Increasing levels of BMI conferred an increased risk of ovarian cancer mortality in women above the age of 50 years. (Source: International Journal of Epidemiology)

Karyometry in atypical endometrial hyperplasia: A Gynecologic Oncology Group study.

Gynecologic Oncology — Fri, 09 Dec 2011 05:00:00 +0100

CONCLUSIONS: AEH comprises cases which may constitute a low risk group involving <40% of AEH cases. These cases hold a percentage of <20% of nuclei of a preneoplastic phenotype. AEH cases from the central and high end of progression have >40% of nuclei of preneoplastic phenotype. Nuclei of the preneoplastic phenotype in AEH lesions are almost indistinguishable from nuclei in SIEC, where this percentage exceeds 60%. The percentage of nuclei of the preneoplastic phenotype in AEH lesions might serve as criterion for assessment of risk for the development of invasive disease. PMID: 22155796 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Diabetes and risk of esophageal and gastric adenocarcinomas

International Journal of Cancer — Thu, 08 Dec 2011 05:00:00 +0100

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Association of number of positive nodes and cervical stroma invasion with outcome of advanced endometrial cancer treated with chemotherapy or whole abdominal irradiation: A Gynecologic Oncology Group Study.

Gynecologic Oncology — Thu, 08 Dec 2011 05:00:00 +0100

CONCLUSIONS: The presence of CSI and increasing number of PPN were associated with poor prognosis. On average, patients with CSI experienced improved PFS and OS when treated with AP relative to WAI. PMID: 22155678 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Catholic church should allow nuns to take contraceptive pill to reduce mortality rate, say scientists

Guardian Unlimited Science — Wed, 07 Dec 2011 18:06:52 +0100

Not having children puts nuns at a greater risk of cancer – and a loophole in the rules allows them to take the pillNuns should be given the contraceptive pill to reduce the high death rates from breast, ovarian and uterine cancer that result from their childlessness, say scientists.Not having children is a risk factor for cancer because pregnancy, as well as breastfeeding a baby, reduces the number of ovulatory cycles a woman has in her lifetime. More ovulatory cycles increases cancer risk. Women who begin their periods at an early age and hit the menopause late also have a higher risk.In the first half of the 20th century, scientists who studied nearly 32,000 Catholic nuns in the US established that their death rates from breast, ovarian and uterine cancer were higher than for other wo...

Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes

Journal of Cancer Research and Clinical Oncology — Tue, 06 Dec 2011 17:01:19 +0100

Conclusion These results suggest that common genetic variations in these pathways may modulate risk and clinical outcomes of endometrial cancer. Further replication and functional studies are needed to confirm these findings. Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-011-1103-0Authors Li-E Wang, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAHongxia Ma, Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USAKatherine S. Hale, Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USAMing Yin, Department of Epidemiology, U...

GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells

Breast Cancer Research and Treatment — Tue, 06 Dec 2011 16:59:09 +0100

Abstract Early growth response-1 (Egr-1) is an immediate early gene involved in relevant biological events including the proliferation of diverse types of cell tumors. In a microarray analysis performed in breast cancer cells, 17β-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER. Hence, in this study, we aimed to provide evidence regarding the ability of E2, OHT and the selective GPER ligand G-1 to regulate Egr-1 expression and function through the GPER/EGFR/ERK transduction pathway in both Ishikawa (endometrial) and SkBr3 (breast) cancer cells. Interestingly, we demonstrate that Egr-1 is involved in the transcription of genes regulating cell proliferation like CTGF and ...

Do uterine risk factors or lymph node metastasis more significantly affect recurrence in patients with endometrioid adenocarcinoma?

Gynecologic Oncology — Tue, 06 Dec 2011 05:00:00 +0100

CONCLUSIONS: Patients with H-IR disease based on uterine characteristics alone have substantial risk of nodal involvement. Knowledge of LN status may better define risk, prognosis, and postoperative treatment. PMID: 22155415 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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The impact of a cancer Survivorship Care Plan on gynecological cancer patient and health care provider reported outcomes (ROGY Care): study protocol for a pragmatic cluster randomized controlled trial

Trials — Mon, 05 Dec 2011 05:00:00 +0100

DiscussionThe ROGY Care trial will help to gain insight into the impact of SCP care on patient reported outcomes, and on the evaluation of cancer survivors and health care providers of the different elements of the SCP. Therefore, results will contribute to efforts to improve quality of care for cancer survivors.Trial Registration: http://www.ClinicalTrials.gov. Identifier: NCT01185626Medical Research Ethics Committee Reference Number: NL33429.008.10 Grant Reference Number: UVT2010-4743 (Source: Trials)

Robotic‐assisted surgery in the management of endometrial cancer

Journal of Obstetrics and Gynaecology Research — Mon, 05 Dec 2011 05:00:00 +0100

AbstractAdvanced laparoscopic procedures for hysterectomy and staging lymphadenectomy were not widely adopted for management of endometrial cancer despite nearly 20 years of improvements in laparoscopic technology. Many surgeons have recently embraced da Vinci robotic‐assisted laparoscopy in preference to traditional laparoscopy because of its technological advantages of wristed instrumentation, high‐definition 3‐D optics, ergonomics and autonomy of camera control; the majority of women with endometrial cancer in the USA now undergo robotic‐assisted surgery. The purpose of this article is to review the robotic surgical techniques for hysterectomy, pelvic and aortic lymphadenectomy procedures, and the current comparative literature discussing perioperative outcomes. Additionally, ...

Targeting the mTOR/4E-BP Pathway in Endometrial Cancer.

Clinical Cancer Research — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Korets SB, Czok S, Blank SV, Curtin JP, Schneider RJ Abstract Endometrial cancer is the most common gynecologic malignancy. Although it is highly treatable in the early stages of disease, therapies for advanced and recurrent disease are rarely curative. A molecular and genetic understanding of endometrial cancer involves the mammalian target of rapamycin (mTOR) signaling pathway, an emerging target for treatment of type I disease (the most common presentation). Endometrial cancers show a significant reliance on the mTOR pathway for survival, and studies to date have revealed a clinical advantage in targeting this pathway. Less well developed in the study of endometrial cancer is an understanding of mTOR signaling to its major downstream effector, translational control. Giv...

Diagnostic delay, quality of life and patient satisfaction among women diagnosed with endometrial or ovarian cancer: a nationwide Danish study

Quality of Life Research — Sat, 03 Dec 2011 16:50:31 +0100

Conclusions We found that few QoL measures were associated with total delay and survival for ovarian cancer, while a number of associations were found between QoL, total delay and survival for endometrial cancer patients. This supports the hypothesis that long total delay may influence QoL and survival for some cancer patients. Reduced patient satisfaction with the diagnostic phase was also statistically significantly associated with long total delay, highlighting that total delay is an important component in patients’ evaluation of the care they receive. Content Type Journal ArticlePages 1-7DOI 10.1007/s11136-011-0077-3Authors Kirstine M. Robinson, Department of Health Services Research, Institute of Public Health, Copenhagen University, Oester Farimagsgade 5B,...

Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.

Gynecologic Oncology — Sat, 03 Dec 2011 05:00:00 +0100

CONCLUSIONS: The increased expression of ER stress markers in endometrioid endometrial carcinomas suggests a role for ER stress, the UPR and, possibly, GRP78 in endometrial cancer. Whether this mechanisms have a substantial function in the pathogenesis of malignant transformation of human endometrium is still under investigation in our laboratory. PMID: 22146569 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Estimation of Cancer Incidence and Mortality Attributable to Overweight, Obesity, and Physical Inactivity in China.

Nutrition and Cancer — Fri, 02 Dec 2011 05:00:00 +0100

This study evaluated the proportion of cancers of colon, rectum, pancreas, breast (postmenopausal), endometrium, and kidney attributable to overweight [30 kg/m(2) > body mass index (BMI) ≥ 25 kg/m(2))/obesity (BMI ≥ 30 kg/m(2)) and physical inactivity in China in 2005. Data of prevalence of overweight/obesity and lack of physical activity were derived from cross-sectional surveys among representative samples of Chinese population, and data of relative risks on cancers were derived from meta-analyses or large-scale studies from China and East Asian populations. The attributable fractions were calculated by combining both data of prevalence and relative risks. In China in 2005, 0.32% of cancer deaths and 0.65% of cancer cases were attributable to overweight and obesity combined. Lack ...

Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells

Cancer Letters — Fri, 02 Dec 2011 05:00:00 +0100

This study demonstrates that endogenous IGFBP-3 modulates adhesion–migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease. (Source: Cancer Letters)

Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors

Journal of Affective Disorders — Thu, 01 Dec 2011 14:23:58 +0100

This study assessed the association between Type D personality (the conjoint effect of negative affectivity and social inhibition) and quality of life (QoL) and mental health of cancer survivors up to 10years post-diagnosis.Methods: All currently alive individuals diagnosed with endometrial or colorectal cancer between 1998 and 2007, or with lymphoma or multiple myeloma between 1999 and 2008 as registered in the Eindhoven Cancer Registry received a questionnaire on Type D personality (DS14), QoL (SF-36 or EORTC-QLQ-C30) and mental health (HADS).Results: Of the 3080 survivors who responded (69%), 572 (19%) had a Type D personality. Type D survivors had clinically meaningful lower levels of general health, social functioning, role-function emotional, mental health and vitality compared to no...

A phase II study single agent of aflibercept (VEGF Trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma. A trial of the Princess Margaret Hospital, Chicago and California Cancer Phase II Consortia.

Gynecologic Oncology — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSIONS: Single agent aflibercept has modest activity in patients with uterine leiomyosarcoma and minimal activity in women with carcinosarcoma. PMID: 22138373 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

[Synchronous primary endometrial and fallopian tube cancers: one case report].

Journal of Southern Medical University — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Wang H, Xiao SS, Zeng F Abstract OBJECTIV: A patient was admitted for menopause for 2 years and abnormal vaginal bleeding and abdominal pain for 2 months. Gynecological examination revealed uterine atrophy without abnormal findings in the bilateral adnexa. CA125 and CEA levels were normal. The patient underwent laparoscopically assisted vaginal hysterectomy with bilateral salpingo-oophorectomy. Pathological examination of the surgical specimens revealed synchronous primary cancers stage Ia in both the endometrium and the right fallopian tube. The patient then received 6 cycles of chemotherapy with oxaliplatin combined with docetaxel given intravenously and remained alive without evidence of recurrence. Synchronous primary endometrial and fallopian tube cancer is a rare cli...

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Endometrial adenocarcinoma mimicking cervical glandular neoplasia in liquid‐based cervical cytology samples

Cytopathology — Thu, 01 Dec 2011 05:00:00 +0100

(Source: Cytopathology)

Clear Cell Cancer of the Uterine Corpus: The Association of Clinicopathologic Parameters and Treatment on Disease Progression

Clinical and Developmental Immunology — Wed, 30 Nov 2011 23:54:38 +0100

This paper presents a single-institution experience regarding the clinicopathologic features and treatment strategies used in uterine clear cell cancer (UCC), a rare, aggressive histologic subtype of uterine cancer with poor prognosis and discusses parameters associated with progression-free survival (PFS) and overall survival (OS). A retrospective chart review was performed on all patients (n=80) diagnosed with UCC and treated between 1994 and 2009 at a single academic institution. Data on demographics, FIGO stage, treatment regimens, and recurrences were collected. Patients with early-stage UCC had an excellent survival regardless of adjuvant therapy. Advanced-stage patients had a worse survival. Vaginal apex brachytherapy was associated with an increased OS (P=0.02) but not PFS (P=0.10)...

ADHD and Menopause: What You Need to Know and What You Can Do

Psych Central — Wed, 30 Nov 2011 14:35:48 +0100

It’s hard enough having attention deficit hyperactivity disorder (ADHD). But if you’re a woman going through perimenopause or menopause, you might find it getting even harder. Diminishing estrogen levels can actually exacerbate symptoms, and for some women, the decline is sudden and dramatic. Hormonal fluctuations affect our brain’s biochemistry and thereby ADHD symptoms, according to Dr. Patricia Quinn, M.D., a developmental pediatrician and director of the National Center for Girls and Women with AD/HD. Specifically, estrogen affects the release of the neurotransmitters serotonin and dopamine. “[A deficiency in] dopamine is responsible for increasing ADHD symptoms,” she said, while less serotonin leads to depressed mood. (That’s why women feel so miserable during their mens...

Endometrial cancer imaging.

Bulletin du Cancer — Wed, 30 Nov 2011 05:00:00 +0100

Authors: Taïeb S, Rocourt N, Narducci F, Ceugnart L Abstract Endometrial cancer is staged according to the International Federation of Gynecology and Obstetrics surgical system. Clinical estimation of stage, however, can be inaccurate in more than 20%, and therefore, preoperative imaging of the disease may assist in planning the optimal course of treatment. Magnetic resonance imaging (MRI) may detect gross myometrial extension or extension of tumor to the cervical stroma, which can alter management and therefore help in preoperative surgical planning. This issue is increasingly relevant as less invasive surgical techniques, such as laparoscopic surgeries, are becoming more commonplace for lower stage cancers. Currently, MRI is the most widely used modality for preoperative plannin...

Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma

Archives of Gynecology and Obstetrics — Wed, 30 Nov 2011 04:39:02 +0100

Conclusions TEC should be offered as an adjuvant therapy to Stage III/IV patients. TC may be considered for recurrent or unresectable cases as a remission induction therapy. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-7DOI 10.1007/s00404-011-2154-9Authors Kazuko Fujiwara, Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1179-3, Higashinari-ku-Nakamichi, Osaka, 537-8511 JapanTomomi Egawa-Takata, Department of Obstetrics and Gynecology, Osaka Police Hospital, 10-31, Kitayama-cho, Tennoji-ku, Osaka 543-0035, JapanYutaka Ueda, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanToshihiro Kimura, Department of Obstetrics and Gynecology,...

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Long-Term Coffee Consumption Associated With Reduced Endometrial Cancer Risk

Cancer Network — Mon, 28 Nov 2011 12:00:00 +0100

Coffee is emerging as a protective agent against a number of diseases, including cancer. A study published last week shows that women who drank more than four cups of coffee per day cut their risk of endometrial cancer by 25% compared with those who drank less than one cup per day. (Source: Cancer Network)

Staging of endometrial carcinomas with MRI using traditional and novel MRI techniques

Clinical Radiology — Mon, 28 Nov 2011 05:00:00 +0100

Endometrial carcinoma is the most common gynaecological malignancy in industrialized countries. This review discusses the value of magnetic resonance imaging (MRI) and novel MRI techniques (diffusion, perfusion, spectroscopy, blood oxygen level-dependent (BOLD)-MRI, and MRI with new contrast agents) in endometrial carcinomas. Contrast-enhanced MRI is the imaging technique of choice, and diffusion-weighted MRI may help to identify malignant lesions and assess myometrial invasion. Novel MRI techniques may potentially increase diagnostic accuracy, enabling a refined, tailored surgical procedure and better prediction of treatment outcomes. (Source: Clinical Radiology)

Commentary on: Staging of endometrial carcinomas with MRI using traditional and novel MRI techniques

Clinical Radiology — Mon, 28 Nov 2011 05:00:00 +0100

In their review, Haldorsen and Salvesen discuss the role of magnetic resonance imaging (MRI) in the staging of endometrial cancer. They present an evaluation of the published evidence and compare the accuracy, sensitivity, and specificity of the MRI information with the reference standard postoperative pathological assessment. Although MRI (particularly contrast-enhanced MRI) performs well in assessing the depth and extent of myometrial invasion, it appears to be less sensitive in identifying cervical involvement and the presence of metastatic lymph nodes. Although several groups who have assessed the use of MRI in endometrial cancer have proposed various potential benefits for its use in routine preoperative practice, as yet there is no evidence that it has improved treatment outcome in t...

The Epidemiology of Endometrial and Ovarian Cancer

Hematology/Oncology Clinics of North America — Mon, 28 Nov 2011 05:00:00 +0100

Late menarche, giving birth, breastfeeding, oral contraceptive use, IUD use, and tubal ligation decrease risk for both endometrial and ovarian cancer, while more ovulatory cycles, obesity, use of talc in genital hygiene, and late menopause increase risk. Despite these similarities, different explanations are proposed: estrogen excess for endometrial and incessant ovulation for ovarian cancer. Common pathways could include reproductive tissue turnover with accumulation of PTEN or p53 mutations or an immunebased explanation involving mucin proteins. Seeking unified explanations for risk factors common to both cancers could lead to new perspectives on how to prevent these common and lethal gynecologic cancers. (Source: Hematology/Oncology Clinics of North America)

Morphological characteristics and co-stimulatory molecule (CD80, CD86, CD40) expression in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 28 Nov 2011 05:00:00 +0100

Conclusion: It is suggested that morphological differences and low expression of co-stimulatory molecules on TIDCs in endometrioid adenocarcinoma reflected the functional changes of the TIDCs in uptake, processing and presenting antigen, which may lead to the occurrence of tumor immune escape. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

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Endometrial cancer - reduce to the minimum. A new paradigm for adjuvant treatments?

Radiation Oncology — Fri, 25 Nov 2011 05:00:00 +0100

Conclusion: Recent data from randomised trials indicate that external beam radiation therapy - particularly in combination with extended lymph node dissection - or radical lymph node dissection increases toxicity without any improvement of overall survival rates. Thus, reduced surgical aggressiveness and limitation of radiotherapy to vaginal-vault-brachytherapy only is sufficient for most cases of early stage endometrial cancer. (Source: Radiation Oncology)

An economic analysis of robotic versus laparoscopic surgery for endometrial cancer: Costs, charges and reimbursements to hospitals and professionals.

Gynecologic Oncology — Fri, 25 Nov 2011 05:00:00 +0100

CONCLUSIONS: Our data showed that the direct costs and charges associated with robotic surgery were higher compared to laparoscopic surgery. However, actual reimbursements to the hospital, surgeon, and anesthesiologist were not significantly different between the two surgical approaches. PMID: 22120176 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

More Cups of Java Cut Endometrial Cancer Risk (CME/CE)

MedPage Today Endocrinology — Fri, 25 Nov 2011 03:13:07 +0100

(MedPage Today) -- Women who drank more than four cups of coffee daily had a 25% lower risk of endometrial cancer as compared with women who consumed less, data from a large prospective cohort study showed. (Source: MedPage Today Endocrinology)

Coffee may reduce endometrial cancer risk

Health News - UPI.com — Thu, 24 Nov 2011 03:41:38 +0100

BOSTON, Nov. 23 (UPI) -- Women who are long-term coffee drinkers are associated with a reduced risk for endometrial cancer, U.S. researchers say. (Source: Health News - UPI.com)

Four cups of coffee a day 'can help prevent womb cancer' - even if they're decaff

the Mail online | Health — Thu, 24 Nov 2011 03:10:45 +0100

Research has linked regular consumption of the popular morning pick-me-up beverage with lower odds of endometrial cancer, the most common form of the disease. (Source: the Mail online | Health)

Advancements in the use of blood tests for cancer screening in women at high risk for endometrial and breast cancer

Future Oncology — Wed, 23 Nov 2011 15:45:21 +0100

Future Oncology , December 2011, Vol. 7, No. 12, Pages 1399-1414. (Source: Future Oncology)

Preclinical studies on histone deacetylase inhibitors as therapeutic reagents for endometrial and ovarian cancers

Future Oncology — Wed, 23 Nov 2011 15:45:19 +0100

Future Oncology , December 2011, Vol. 7, No. 12, Pages 1415-1428. (Source: Future Oncology)

Coffee may prevent endometrial cancer: How much does it take?

Health News: CBSNews.com — Wed, 23 Nov 2011 14:05:14 +0100

Women who drink more than four cups of coffee per day 25 percent less likely to get deadly malignancy, study says (Source: Health News: CBSNews.com)

Coffee May Protect Against Endometrial Cancer

Health News from Medical News Today — Wed, 23 Nov 2011 09:00:00 +0100

Long-term coffee consumption may be associated with a reduced risk for endometrial cancer, according to a recent study in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Edward Giovannucci, M.D., Sc.D., professor of nutrition and epidemiology at the Harvard School of Public Health, said coffee is emerging as a protective agent in cancers that are linked to obesity, estrogen and insulin. "Coffee has already been shown to be protective against diabetes due to its effect on insulin," said Giovannucci, a senior researcher on the study... (Source: Health News from Medical News Today)

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Coffee May Cut Endometrial Cancer Risk

MedicineNet Cancer General — Wed, 23 Nov 2011 07:00:00 +0100

Title: Coffee May Cut Endometrial Cancer RiskCategory: Health NewsCreated: 11/23/2011 11:01:00 AMLast Editorial Review: 11/23/2011 (Source: MedicineNet Cancer General)