MedWorm: Esophagus Cancer

Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation

Journal of Experimental and Clinical Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Conclusion: Overexpression of GADD45alpha gene is due to DNA hypomethylation in ESCC. GADD45alpha may be a protective factor in DDP chemotherapy for esophageal squamous cell carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)

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Do gastric adverse events influence the choice of bisphosphonate for the treatment of osteoporosis?

NeLM - Medicines Q and A — Wed, 08 Feb 2012 05:00:00 +0100

Source: Regional Drug and Therapeutics Centre Area: Evidence > Medicines Q & A The bisphosphonates are a group of drugs used to reduce bone turnover in conditions including osteoporosis, Paget's disease, and bone malignancies. The therapeutic effect is achieved by inhibiting bone resorption. As a group the bisphosphonates are generally well tolerated, but have a well documented adverse effect (AE) profile, and gastrointestinal effects are a known issue. Strict administration requirements have been introduced to reduce the risk of oesophageal AEs, and inability to meet these requirements is considered a contraindication to treatment. There have been reports of pain, nausea, vomiting and gastric ulcers associated with bisphosphonate use. (Source: NeLM - ...

Angiotensin‐I converting enzyme inhibitors suppress angiogenesis and growth of esophageal carcinoma xenografts

Diseases of the Esophagus — Mon, 06 Feb 2012 05:00:00 +0100

SUMMARYIt has recently been suggested that angiotensin‐I converting enzyme (ACE) inhibitors decrease the risk of cancer. However, studies to date have not investigated esophageal carcinoma. Therefore, we investigated the inhibitory effect of ACE inhibitors on growth of esophageal carcinoma xenografts. We used the EC9706 cell line, which expresses the highest vascular endothelial growth factor (VEGF) mRNA level, to establish xenografts in 21 BALB/c nude mice. The mice were then randomly allocated to receive normal saline, perindopril (4 mg/kg), or benazepril (6 mg/kg). Five weeks later, the nude mice were sacrificed and all tumors were dissected and weighed. The number of microvessels was counted by immunostaining endothelial cells for CD31 and the microvessel density was assessed. Th...

Immunohistochemical study of the muscularis externa of the esophagus in achalasia patients

Diseases of the Esophagus — Mon, 06 Feb 2012 05:00:00 +0100

In conclusion, the pathophysiology of achalasia is therefore considered to be an impaired production of NO and VIP, which both affect interstitial cell of Cajal and smooth muscles, and this impairment is therefore considered to play a role in the pathophysiology of achalasia. (Source: Diseases of the Esophagus)

Six-Organ Transplant Girl Goes Home Today

Health News from Medical News Today — Fri, 03 Feb 2012 18:00:00 +0100

After 100 days in hospital and undergoing a complicated 6-organ transplant, 9-year-old Alannah Shevenell, from Maine, leaves Boston Children's Hospital today and goes home. Alannah has been treated for a rare form of cancer; an inflammatory myofibroblastic tumor continued to grow after all possible treatments failed, and was compromising her internal organs. A team of surgeons, led by Dr. Heung Bae Kim, the hospital's Pediatric Transplant Center director, performed the transplant procedure of Alannah's liver, spleen, pancreas, stomach, small intestine and esophagus... (Source: Health News from Medical News Today)

The microRNAs, MiR‐31 and MiR‐375, as candidate markers in Barrett's esophageal carcinogenesis

Genes, Chromosomes and Cancer — Fri, 03 Feb 2012 05:00:00 +0100

AbstractThere is a critical need to identify molecular markers that can reliably aid in stratifying esophageal adenocarcinoma (EAC) risk in patients with Barrett's esophagus. MicroRNAs (miRNA/miR) are one such class of biomolecules. In the present cross‐sectional study, we characterized miRNA alterations in progressive stages of neoplastic development, i.e., metaplasia–dysplasia–adenocarcinoma, with an aim to identify candidate miRNAs potentially associated with progression. Using next generation sequencing (NGS) as an agnostic discovery platform, followed by quantitative real‐time PCR (qPCR) validation in a total of 20 EACs, we identified 26 miRNAs that are highly and frequently deregulated in EACs (≥4‐fold in >50% of cases) when compared to paired normal esophageal squamou...

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Human papillomavirus detected in esophageal squamous cell carcinoma in Iran.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:02 +0100

CONCLUSION: In conclusion, the present study showed that a small proportion of ESCC specimens from Iran harbor HPV16, 18 genome using a highly sensitive method. As different rates have been reported from Iran, a more widespread study with more precise definition of geographical differences could delineate the potential involvement of HPV in the development of ESCC in Iranian population. PMID: 22284258 [PubMed - in process] (Source: European Journal of Internal Medicine)

Smoking cessation recommended for BE patients

MedWire News - Gastroenterology — Thu, 02 Feb 2012 21:10:16 +0100

Patients with Barrett’s esophagus should be encouraged to give up smoking, say researchers who found the habit doubles the risk for progression to esophageal cancer. (Source: MedWire News - Gastroenterology)

Endotracheal metastasis from basaloid squamous carcinoma of the esophagus

Esophagus — Thu, 02 Feb 2012 18:15:46 +0100

We describe a rare case of metachronous endotracheal metastasis originating from esophageal basaloid squamous carcinoma. A 72-year-old Japanese man underwent esophagectomy for stage I esophageal cancer. Pathological diagnosis of the resected specimen was basaloid squamous carcinoma. One year later, a follow-up computed tomography scan displayed a tumor shadow in the tracheal wall. Bronchoscopy revealed a protruding tumor in the tracheal wall, and the pathologic diagnosis of the biopsy specimen was also basaloid squamous carcinoma. According to the diagnosis of metachronous endobronchial metastasis from esophageal basaloid squamous carcinoma, we treated the patient with chemotherapy comprising docetaxel, cisplatin, and 5-fluorouracil followed by chemoradiotherapy, and complete respons...

Comparison Between Radical Esophagectomy and Definitive Chemoradiotherapy in Patients with Clinical T1bN0M0 Esophageal Cancer

Annals of Surgical Oncology — Thu, 02 Feb 2012 18:12:36 +0100

Conclusions Selection of patients at high risk of pathologic lymph node metastasis is essential when formulating treatment decisions for clinical T1bN0M0 esophageal cancers. Content Type Journal ArticleCategory Gastrointestinal OncologyPages 1-7DOI 10.1245/s10434-012-2231-8Authors Masaaki Motoori, Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, JapanMasahiko Yano, Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, JapanRyu Ishihara, Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, JapanSachiko Yamamoto, Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, JapanYoshifumi K...

Endoscopic laser fragmentation and removal of a nonremovable metal esophageal stent for persistent dysphagia: a technical note

Surgical Endoscopy — Thu, 02 Feb 2012 18:07:53 +0100

Conclusions We describe a successful technique for the removal of a nonretrievable stent using laser fracture and endoscopic retrieval. This method of stent removal has not been previously reported. Content Type Journal ArticleCategory TechniquePages 1-3DOI 10.1007/s00464-011-2111-5Authors Ross S. Coomber, Department of Upper GI Surgery, West Herts NHS Trust, Watford General Hospital, Vicarage Road, Watford, WD18 0HB UKPranav H. Patel, Department of Upper GI Surgery, West Herts NHS Trust, Watford General Hospital, Vicarage Road, Watford, WD18 0HB UKAnubhav Dhir, Department of Healths Clinical Advisor Scheme, Bupa Health Dialog, London, UKJeremy I. Livingstone, Department of Upper GI Surgery, West Herts NHS Trust, Watford General Hospital, Vicarage Road, Watford, WD18...

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Smoking cessation recommended for BE patients

MedWire News - Oncology — Thu, 02 Feb 2012 13:23:49 +0100

The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: The role of deoxycholic acid.

American Journal of Physiology. Gastrointestinal and Liver Physiology — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Roesly HB, Khan MR, Chen HD, Hill KA, Narendran N, Watts GS, Chen X, Dvorak K Abstract Beclin-1 has a central role in the regulation of autophagy. Barrett's esophagus (BE) is associated with a significantly increased risk for the development of esophageal adenocarcinoma (EAC). In the current study, we evaluated the role of Beclin-1 and autophagy in the esophageal carcinogenesis. Biopsies obtained from patients with BE and EAC, tissues from a rat model of BE and EAC, and esophageal cell lines were evaluated for the expression of Beclin-1 by immunohistochemistry, immunoblotting, or RT-PCR. Since reflux of bile acids is important in esophageal carcinogenesis, we also evaluated the effect of exposure to deoxycholic acid (DCA) on autophagy and Beclin-1 expression. Beclin-1 expr...

Minimally invasive intrathoracic anastomosis after Ivor Lewis esophagectomy for cancer: a review of transoral or transthoracic use of staplers

Surgical Endoscopy — Wed, 01 Feb 2012 18:26:14 +0100

Conclusions This review has found no important differences between the two most frequently used stapled anastomoses: the transoral introduction of the anvil and the transthoracic. Clinical trials are needed to compare different methods to improve the quality of the intrathoracic anastomosis after esophagectomy. Content Type Journal ArticleCategory ReviewPages 1-8DOI 10.1007/s00464-012-2149-zAuthors K. W. Maas, Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsS. S. A. Y. Biere, Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsJ. J. G. Scheepers, Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsS. S....

9-Year-Old Girl Heading Home After 6 Organ Transplant At Children’s Hospital

Wed, 01 Feb 2012 13:14:26 +0100

BOSTON (AP) — A 9-year-old Maine girl is heading home after a groundbreaking multiple organ transplant at Children’s Hospital Boston. Alannah Shevenell of Hollis underwent 14 hours of surgery in October to remove an aggressive tumor and to undergo a transplant of her stomach, pancreas, spleen, liver, small bowel and esophagus. Hospital officials say it was the first known esophageal transplant in the world and the largest number of organs transplanted into a person at one time in New England. Alannah was diagnosed with a rare former of cancer when she was 4. The tumor snaked and twisted itself around her internal organs, choking the life out of them. It didn’t respond to chemotherapy or surgery to get rid of it. Even the transplant was risky. Alannah is scheduled to come Wedn...

Barrett's Patients Who Smoke Are Twice As Likely To Develop Esophageal Cancer

Health News from Medical News Today — Wed, 01 Feb 2012 08:00:00 +0100

Barrett's esophagus (BE) patients who smoke tobacco are at a two-fold increased risk of developing esophageal cancer, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. BE patients who smoke also double their risk for developing advanced precancerous cells. "We found that tobacco smoking emerged as the strongest lifestyle risk factor for cancer progression. Contrary to popular belief, alcohol consumption didn't increase cancer risk in this group of patients with Barrett's esophagus," said Helen G... (Source: Health News from Medical News Today)

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"Prognostic factors for esophageal squamous cell carcinoma - a population-based study in golestan province, iran, a high incidence area".

Archives of Iranian Medicine — Wed, 01 Feb 2012 05:00:00 +0100

"Prognostic factors for esophageal squamous cell carcinoma - a population-based study in golestan province, iran, a high incidence area". Arch Iran Med. 2012 Feb;15(2):118-9 Authors: Nasseri-Moghaddam S, Dawsey SM PMID: 22292587 [PubMed - in process] (Source: Archives of Iranian Medicine)

Significance of Lymph Node Capsular Invasion in Esophageal Squamous Cell Carcinoma

Annals of Surgical Oncology — Tue, 31 Jan 2012 07:11:04 +0100

Conclusions LNCI in ESCC patients is an indicator of distant organ recurrence and a worse prognosis. LNCI could be used as a candidate marker for designing more precise staging and therapeutic strategies for ESCC. Content Type Journal ArticleCategory Gastrointestinal OncologyPages 1-7DOI 10.1245/s10434-012-2232-7Authors Makoto Sakai, Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, JapanShigemasa Suzuki, Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, JapanAkihiko Sano, Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, JapanNaritaka Tanaka, Department of General Surgical Science, Gunma University, Graduate School of Medicine,...

A successful rescue with extra-anatomical bypass for massive bleeding of the brachiocephalic artery following salvage pharyngo-esophagectomy

Esophagus — Tue, 31 Jan 2012 07:07:17 +0100

Abstract Massive bleeding from large vessels is a serious and life-threatening complication after radical esophagectomy. Here, we present the rare case of patient survival following two episodes of massive bleeding from a tracheo-brachiocephalic artery fistula after salvage surgery for cervical esophageal cancer following definitive chemoradiation. During the first episode of bleeding, the damaged part of the brachiocephalic artery was transected with an extra-anatomical arterial bypass (right femoro-axillo artery bypass graft) to maintain the arterial blood flow to the brain and the free jejunal graft. During the second bleeding, the distal stump of the brachiocephalic artery was reclosed. During both episodes of bleeding, the musculocutaneous flap was effectively employe...

Pre-treatment plasma proteomic markers associated with survival in oesophageal cancer

British Journal of Cancer AOP — Tue, 31 Jan 2012 05:00:00 +0100

Authors: P Kelly, F Paulin, D Lamont, L Baker, S Clearly, D Exon & A Thompson (Source: British Journal of Cancer AOP)

Endocrine phenotype of children and adults with Fanconi anemia

Pediatric Blood and Cancer — Tue, 31 Jan 2012 05:00:00 +0100

ConclusionsWe have evaluated in detail children and adults with FA for their growth and endocrine function. Overall, 79% of children and adults with FA had one or more endocrine abnormality. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

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Influence of socioeconomic environment on survival in patients diagnosed with esophageal cancer: a population‐based study

Diseases of the Esophagus — Tue, 31 Jan 2012 05:00:00 +0100

SUMMARYThe influence of social environment on survival in patients with cancer has been demonstrated in many studies, subjects living in the most deprived areas having a poorer prognosis. Geographic remoteness and limited access to specialized care centers are often associated with socioeconomic deprivation. The aim was to assess the influence of social environment and geographic remoteness on the relative survival of patients diagnosed with esophageal cancer between 1997 and 2004 in the department of Calvados in France. The study population, which was provided by the Calvados digestive cancer registry, included 629 patients. Relative survival was used to estimate the influence of social environment and geographic remoteness on patient survival. Five‐year survival rates were 14.1%, 15.1%...

Ten cases of gastro‐tracheobronchial fistula: a serious complication after esophagectomy and reconstruction using posterior mediastinal gastric tube

Diseases of the Esophagus — Tue, 31 Jan 2012 05:00:00 +0100

SUMMARYGastro‐tracheobronchial fistula (GTF) is a rare but life‐threatening complication specifically observed after esophagectomy and reconstruction using posterior mediastinal gastric tube. Ten cases of GTF were encountered in three hospitals in 2000–2009. Their clinicopathological, surgical, and postoperative care are summarized, together with a review of previously reported cases. GTF was classified as anastomotic leakage (n= 5), gastric necrosis (n= 4), and gastric ulcer type (n= 1). The anastomotic leakage type appeared about 2 weeks (postoperative day [POD]: 8–35) after esophagectomy, was located in the cervical or higher thoracic trachea. Breathing and pneumonia were controlled by tracheal tube placed in the distal of fistula. The gastric necrosis type was noted in patients...

Immunohistochemical study of nuclear factor‐κB expression in esophageal squamous cell carcinoma: prognostic significance and sensitivity to treatment with 5‐FU

Diseases of the Esophagus — Tue, 31 Jan 2012 05:00:00 +0100

This study evaluated the relationship between the expression of NF‐κB and the prognosis and sensitivity of esophageal squamous cell carcinoma (ESCC) to chemotherapy. One hundred and nine ESCC specimens, from patients who had undergone radical esophagectomy, were divided into two groups depending on the expression of NF‐κB. Surgical data and prognosis were compared between the two groups. NF‐κB‐positive tumors were detected in 61.5% of the cases. In 69 patients with stage II and III disease, 41 patients who were NF‐κB‐positive showed poor survival. The sensitivity of esophageal squamous cell carcinoma cell lines to 5‐fluorouracil (5‐FU) was analyzed by their NF‐κB expression, and the effect of 5‐FU was evaluated on the proliferation and activity of two cell lines of...

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells

BMC Molecular Biology - Latest articles — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions: Our work indicates a novel mechanism of miR-34a regulation that NF-kappaB could elevate miR-34a expression levels through directly binding to its promoter. And wildtype p53 is responsible for NF-kappaB-mediated miR-34a transcriptional activity but not for NF-kappaB binding. These findings might be helpful in understanding miR-34a abnormality in human malignancies and open new perspectives for the roles of miR-34a and NF-kappaB in tumor progression. (Source: BMC Molecular Biology - Latest articles)

Neoadjuvant chemoradiation therapy is beneficial for clinical stage t2 n0 esophageal cancer patients due to inaccurate preoperative staging.

The Annals of Thoracic Surgery — Tue, 31 Jan 2012 04:22:39 +0100

CONCLUSIONS: For cT2 N0 esophageal cancer patients, the benefit of neoadjuvant therapy is still unclear. Induction therapy for cT2 N0 did not translate into a statistically significant improvement in survival. However, due to the significant understaging of T2 N0 patients, we recommend neoadjuvant therapy to all cT2N0 patients before operation. PMID: 22269708 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

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Retrocardiac herniation of atelectatic lung into the opposite chest.

The Annals of Thoracic Surgery — Tue, 31 Jan 2012 04:17:46 +0100

Authors: Moss JE, Festic E, Odell JA Abstract A 64-year-old man with a history of esophageal adenocarcinoma status postneoadjuvant therapy underwent esophagogastrectomy. Postoperatively he was found with increasing dyspnea and oxygen requirements. Computed tomography of the chest showed retrocardiac herniation of atelectatic lung into the contralateral hemithorax. PMID: 22269738 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Barrett's patients who smoke are twice as likely to develop esophageal cancer

EurekAlert! - Medicine and Health — Mon, 30 Jan 2012 05:00:00 +0100

(American Gastroenterological Association) Barrett's esophagus patients who smoke tobacco are at a two-fold increased risk of developing esophageal cancer. (Source: EurekAlert! - Medicine and Health)

Barrett's patients who smoke twice as likely to develop oesophageal cancer

EurekAlert! - Medicine and Health — Mon, 30 Jan 2012 05:00:00 +0100

(Queen's University Belfast) Smoking doubles the risk of developing oesophageal cancer in people with Barrett's Oesophagus, according to scientists at Queen's University Belfast and the Northern Ireland Cancer Registry. (Source: EurekAlert! - Medicine and Health)

Heterogeneity of chemosensitivity in esophageal cancer using ATP-tumor chemosensitivity assay.

Acta Pharmacologica Sinica — Mon, 30 Jan 2012 05:00:00 +0100

Conclusion:There was a marked heterogeneity of chemosensitivity in esophageal cancer. Chemosensitivity testing may provide a practical method for testing new regimens before clinical trials in esophageal cancer patients. PMID: 22286916 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

Proteomic research progress in lymphatic metastases of cancers

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:11 +0100

Abstract Lymph node metastasis (LNM) is recognised as an important factor involved in malignant tumour progression by interfering with a favourable prognosis. It is involved in a variety of cancers. Proteins are believed to play important roles in the LNM of cancers. The rapid achievements of state-of-the-art proteomic techniques have emerged as the key technologies successfully applied to identify markers for cancers at high-throughput level by providing novel targets and creating possible therapeutic interventions in cancer research. This review summarises recent progress in proteomic research in hepatocarcinoma, gastric cancer, oesophageal cancer, colorectal cancer, breast cancer, lung cancer and nasopharyngeal cancer. Actin, heat-shock proteins (HSPs), annexins, cytoke...

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Palliative and Supportive Care in Acrometastasis to the Hand: Case Series

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Narendra Kumar, Ritesh Kumar, Anjan Bera, Pankaj Kumar, Shabab L Angurana, Sushmita Ghosal, Radhika Srinivasan, Suresh Chander SharmaIndian Journal of Palliative Care 2011 17(3):241-244Acrometastasis to the hand is an unusual presentation which might mimic an infectious, inflammatory, or a metabolic pathology. We herein describe a case series of three patients of acrometastasis to the hand. We encountered three cases of acrometastasis to the hand attending the departmental clinics from 2007 to 2010. The median age at presentation was noted to be 55 years. All were males. The primaries included squamous cell carcinoma of the skin, larynx, and esophagus. In two patients, acrometastasis was detected at presentation and in one it was detected 2 years postcompletion of radical therapy. Two pati...

Population-based study of DNA image cytometry as screening method for esophageal cancer.

World Journal of Gastroenterology : WJG — Sat, 28 Jan 2012 05:00:00 +0100

CONCLUSION: It is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions. PMID: 22294844 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Biomarkers detected patients at risk for esophageal cancer

HemOncToday.com — Fri, 27 Jan 2012 14:17:00 +0100

(Source: HemOncToday.com)

Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma.

Hand Surgery — Fri, 27 Jan 2012 11:42:37 +0100

CONCLUSIONS: LVI detected by D2-40 staining was an independent prognostic factor in patients with node-negative ESCC. J. Surg. Oncol. 2012; 105:277-283. © 2011 Wiley Periodicals, Inc. PMID: 22271500 [PubMed - in process] (Source: Hand Surgery)

Health-Related Quality of Life Among 5-Year Survivors of Esophageal Cancer Surgery: A Prospective Population-Based Study [Gastrointestinal Cancer]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion HRQL recovers to a level comparable to that in the background population in most patients who survive 5 years after esophagectomy for cancer, although a subgroup of patients has substantially worse HRQL. (Source: Journal of Clinical Oncology)

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Sloughing esophagitis is associated with chronic debilitation and medications that injure the esophageal mucosa.

Atherosclerosis — Fri, 27 Jan 2012 05:00:00 +0100

This study seeks to evaluate the clinical findings in patients with SE. Thirty-one patients with necrotic superficial squamous epithelium, with endoscopic white plaques or membranes, but without fungi, were compared with 34 patients having esophageal biopsies done for any purpose other than Barrett's surveillance. Sloughing esophagits patients were older than controls (56 vs 43.5 years) and were more likely to be taking five or more medications (77 vs 32%), especially central nervous system depressants (65 vs 32%) and medications associated with esophageal injury (55 vs 18%). In 69% the plaques were in the distal and/or mid-esophagus; 23% involved the entire esophagus; 8% were limited to the proximal esophagus. There was no correlation between medication history and site. Sloughing esophag...

Genetic cause of esophageal cancer identified

MedWire News - Oncology — Thu, 26 Jan 2012 13:24:50 +0100

UK researchers have pinpointed a single genetic defect that underlies “tylosis with esophageal cancer,” an inherited syndrome that confers a high risk for esophageal cancer. (Source: MedWire News - Oncology)

Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma

BioMed Central — Thu, 26 Jan 2012 05:00:00 +0100

Conclusions: These data reveal insight into genes and molecular pathways mediating ESCC development and provide information potentially useful in designing novel therapeutic interventions for this tumor type. (Source: BioMed Central)

Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS:Short‐term administration of exogenous ghrelin at the start of cisplatin‐based chemotherapy stimulated food intake and minimized adverse events. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)

Video: Photodynamic therapy of the esophagus

MayoClinic.com Full Feed — Wed, 25 Jan 2012 06:00:00 +0100

Photodynamic therapy video shows light treatment for Barrett's esophagus and esophageal cancer. (Source: MayoClinic.com Full Feed)

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Video: Radiofrequency ablation of the esophagus

MayoClinic.com Full Feed — Wed, 25 Jan 2012 06:00:00 +0100

Radiofrequency ablation video shows high-frequency radio wave treatment for Barrett's esophagus and esophageal cancer. (Source: MayoClinic.com Full Feed)

Fluorine-18-fluorodeoxyglucose uptake in a benign oesophageal leiomyoma: a potential pitfall in diagnosis

Interactive CardioVascular and Thoracic Surgery — Wed, 25 Jan 2012 05:00:00 +0100

Positron-emission tomography scans (PET) with fluorine-18-fluorodeoxyglucose (18F- FDG) are usually negative in leiomyomas. Two patients underwent a PET that showed an increased 18F- FDG uptake of the distal oesophagus suggestive for malignancy. Both patients were operated on and histologic examination revealed a benign leiomyoma in both cases. We conclude that oesophageal leiomyomas are a potential cause of a false-positive PET. A high level of caution is needed in these diagnostically challenging cases to prevent unnecessary surgical procedures. (Source: Interactive CardioVascular and Thoracic Surgery)

Major Annoucement on Kidney Cancer Vaccine

Kidney Cancer Association — Tue, 24 Jan 2012 22:27:31 +0100

Roswell Park Launches Landmark Immunotherapy Vaccine Trial [Read More] The ability to stretch out the attack for a long-term, durable response suggests that the vaccine may be effective in preventing disease recurrence. The new NY-ESO-1 dendritic cell vaccine is expected to show great promise in patients with bladder, brain, breast, esophageal, gastrointestinal, hepatocellular, kidney, lung, melanoma, ovarian, prostate, sarcoma and uterine tumors. 01/24/2012 (Source: Kidney Cancer Association)

A case of giant esophageal leiomyoma

Comparative Clinical Pathology — Tue, 24 Jan 2012 12:25:49 +0100

We report a giant spiral leiomyoma that presented with dysphasia and weight loss and enucleated successfully. Content Type Journal ArticleCategory Original ArticlePages 1-3DOI 10.1007/s00580-012-1417-6Authors Rahim Mahmodlu, Urmia University of Medical Sciences, Urmia, IranSona Noori-Vahed, Urmia University of Medical Sciences, Urmia, IranPeyman Mikaili, Urmia University of Medical Sciences, Urmia, IranRahim Mehdioghli, Urmia University of Medical Sciences, Urmia, Iran Journal Comparative Clinical PathologyOnline ISSN 1618-565XPrint ISSN 1618-5641 (Source: Comparative Clinical Pathology)

Metastasis-associated Protein 1 Nuclear Expression is Closely Associated with Tumor Progression and Angiogenesis in Patients with Esophageal Squamous Cell Cancer

World Journal of Surgery — Tue, 24 Jan 2012 07:55:28 +0100

Conclusions High expression of the MTA1 protein is common in ESCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. These findings indicate that MTA1 protein has clinical potentials as a useful indicator of progressive phenotype, a promising prognostic predictor to identify patients with poor prognosis, and a potential novel therapeutic target of antiangiogenesis for patients with ESCC. Content Type Journal ArticlePages 1-9DOI 10.1007/s00268-011-1421-zAuthors Shu-Hai Li, Department of Thoracic Surgery, Qilu Hospital, Shandong University, Wen hua xi lu 107#, Jinan, 250012 Shandong, ChinaHui Tian, Department of Thoracic Surgery, Qilu Hospital, Shandong University, Wen hua xi lu 107#, Jinan, 250012 Shandong, ChinaWei-M...

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Predictive factors for early recurrence in patients with esophageal squamous cell carcinoma after curative esophagectomy

Esophagus — Tue, 24 Jan 2012 07:21:13 +0100

Conclusions Early distant recurrences of esophageal cancer frequently occurred even after curative surgery. The number of pathological lymph node metastases (three or more) was the independent risk factor for early recurrence in patients with esophageal cancer after curative resection. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10388-011-0308-2Authors Hiroki Shimizu, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, 602-8566 JapanAtsushi Shiozaki, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, 602-8566 JapanHitoshi Fujiwara, Division...

Video: Cryotherapy of the esophagus

MayoClinic.com Full Feed — Tue, 24 Jan 2012 06:00:00 +0100

Cryotherapy video shows use of extreme cold treatment for Barrett's esophagus and esophageal cancer. (Source: MayoClinic.com Full Feed)

Video: Esophagectomy

MayoClinic.com Full Feed — Tue, 24 Jan 2012 06:00:00 +0100

Esophagectomy video shows removal of esophagus for treatment of Barrett's esophagus and esophageal cancer. (Source: MayoClinic.com Full Feed)

Subcarinal Node Metastasis in Thoracic Esophageal Squamous Cell Carcinoma [ORIGINAL ARTICLES: GENERAL THORACIC]

The Annals of Thoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions Longer tumor length, higher pathologic T stage, lower histologic grade, and positive lymph node metastases of other groups are associated with a higher frequency of subcarinal node metastasis. Subcarinal node metastasis indicates worse prognosis of patients with thoracic esophageal squamous cell carcinoma compared with paraesophageal node metastasis. (Source: The Annals of Thoracic Surgery)

Invited Commentary [ORIGINAL ARTICLES: GENERAL THORACIC]

The Annals of Thoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

(Source: The Annals of Thoracic Surgery)

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Neoadjuvant Chemoradiation Therapy Is Beneficial for Clinical Stage T2 N0 Esophageal Cancer Patients Due to Inaccurate Preoperative Staging [ORIGINAL ARTICLES: GENERAL THORACIC]

The Annals of Thoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions For cT2 N0 esophageal cancer patients, the benefit of neoadjuvant therapy is still unclear. Induction therapy for cT2 N0 did not translate into a statistically significant improvement in survival. However, due to the significant understaging of T2 N0 patients, we recommend neoadjuvant therapy to all cT2N0 patients before operation. (Source: The Annals of Thoracic Surgery)

Retrocardiac Herniation of Atelectatic Lung Into the Opposite Chest [CASE REPORTS]

The Annals of Thoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

A 64-year-old man with a history of esophageal adenocarcinoma status postneoadjuvant therapy underwent esophagogastrectomy. Postoperatively he was found with increasing dyspnea and oxygen requirements. Computed tomography of the chest showed retrocardiac herniation of atelectatic lung into the contralateral hemithorax. (Source: The Annals of Thoracic Surgery)

Atypical presentation and transabdominal treatment of chylothorax complicating esophagectomy for cancer

Journal of Cardiothoracic Surgery — Tue, 24 Jan 2012 05:00:00 +0100

We report a case of a young adult male who underwent neoadjuvant chemoradiationtherapy followed by Ivor-Lewis esophagectomy for a squamous-cell carcinoma of the distal esophagus. During the postoperative course the patient presented recurrent episodes of hemodynamic instability mimicking cardiac tamponade, secondary to compression of the left pulmonary vein and the left atrium by a mediastinal chylocele. Mediastinal drainage and ligation of the cisterna chyli and the thoracic duct was successfully performed through a transhiatal approach. (Source: Journal of Cardiothoracic Surgery)

A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption. (Source: Annals of Oncology)

Skipping Surgery in Early Esophageal Cancer May Be OK (CME/CE)

MedPage Today Meeting Coverage — Mon, 23 Jan 2012 22:43:06 +0100

SAN FRANCISCO (MedPage Today) -- Non-surgical therapies for stage 0-IA squamous esophageal cancer may be a viable alternative treatment that also provides a chance for organ preservation, according to a Japanese study. (Source: MedPage Today Meeting Coverage)

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Cardiac Risk Higher for Women Getting Radiation

MedPage Today Gastroenterology — Mon, 23 Jan 2012 19:43:03 +0100

SAN FRANCISCO (MedPage Today) -- Women undergoing radiation therapy for esophageal cancer appear to be at greater risk of cardiac complications than men, researchers reported here at the Multidisciplinary Gastrointestinal Cancers Symposium. (Source: MedPage Today Gastroenterology)

Halting Esophageal Cancer in its Tracks with Sugar

Medical Headlines From Ivanhoe.com — Mon, 23 Jan 2012 05:00:00 +0100

(Ivanhoe Newswire) – Scientists working at the Medical Research Council have identified changes in the patterns of sugar molecules that line pre-cancerous cells in the esophagus, a condition called Barrett's dysplasia, making it much easier to detect and remove these cells before they develop into esophageal cancer. (Source: Medical Headlines From Ivanhoe.com)

Discovery Of High Risk Oesophageal Cancer Gene

Health News from Medical News Today — Sun, 22 Jan 2012 08:00:00 +0100

New research from Queen Mary, University of London has uncovered a gene which plays a key role in the development of oesophageal cancer (cancer of the gullet). The researchers studied families who suffer a rare inherited condition making them highly susceptible to the disease and found that a fault in a single gene was responsible. Initial studies suggest that the gene could play a role in the more common, non-inherited form of the disease, revealing a new target for treating this aggressive type of cancer... (Source: Health News from Medical News Today)

Adverse Effects of GI Cancer Therapy Long-Lasting

MedPage Today Hematology/Oncology — Fri, 20 Jan 2012 20:43:07 +0100

SAN FRANCISCO (MedPage Today) -- Years after successful treatment for gastric or esophageal cancer, patients still have complications from therapy, researchers found. (Source: MedPage Today Hematology/Oncology)

Subcutaneous placement of a free jejunum and pedicled colon segment to create a diversionary conduit for total esophageal reconstruction

Microsurgery — Fri, 20 Jan 2012 05:00:00 +0100

In this report, we describe a case of difficult esophageal reconstruction with a pedicled colon segment interposition and a free jejunal flap. Laryngectomy and bilateral neck dissection for larynx carcinoma had been attempted in a 59‐year‐old patient 6 years previously. The patient then received radiotherapy. One year later, large resection was performed due to recurrence of the tumor. Since then the patient had been fed through a gastrostomy tube. Previous attempts at esophageal reconstruction in other institutions were unsuccessful. We reconstructed the total esophagus with subcutaneously tunneled pedicled colon segment interposition and a free jejunal flap using the diversionary loop technique to divert the passage of the foot from the pharynx to the new inlet at the buccogingival s...

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A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley

Indian Journal of Human Genetics — Fri, 20 Jan 2012 05:00:00 +0100

Conclusions: Polymorphism in CASP8 -652 6N ins/del polymorphism modulates the risk of EC and GC in Kashmir valley. (Source: Indian Journal of Human Genetics)

Outcome of four-dimensional stereotactic radiotherapy for centrally located lung tumors.

Fri, 20 Jan 2012 05:00:00 +0100

CONCLUSION: SBRT of central lung lesions can be safely delivered, with promising early tumor control in patients many of whom have severe comorbid conditions. PMID: 22265734 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Impact of Radiotherapy, Chemotherapy and Surgery in Multimodal Treatment of Locally Advanced Esophageal Cancer.

Oncology — Fri, 20 Jan 2012 05:00:00 +0100

Conclusion: Definitive CRT and a trimodality approach including surgery (C-CRT/S) had a comparable outcome in this unselected patient collective. Surgery and higher radiation doses improve LRC rates in subgroups of patients, respectively, but without effect on OS. PMID: 22269965 [PubMed - as supplied by publisher] (Source: Oncology)

Oesophageal Cancer Gene Found

Health News from Medical News Today — Thu, 19 Jan 2012 19:00:00 +0100

UK researchers have found a gene that plays an important part in the development of oesophageal cancer or cancer of the gullet. They announced their news to the press on Thursday. Every year, more than 8,000 people in the UK discover they have oesophageal cancer, and the rates are going up. The disease is more common in the UK than other European countries. The chances of surviving oesophageal cancer are very slim: only 8% of patients are alive more than 5 years after diagnosis... (Source: Health News from Medical News Today)

Discussion

The Journal of Thoracic and Cardiovascular Surgery — Thu, 19 Jan 2012 09:10:17 +0100

Dr Michael Mulligan (Seattle, Wash). Congratulations on your paper and a very nice presentation. I always appreciate seeing a lot of effort put into work, and clearly you did that. I noticed the article that your group put out via e-publication last month evaluating ICAM regulation with sPLA2 in esophageal cancer cells, and this is a nice extension of that work. It is always difficult to know what the next great research question is and you seem to be onto something here. (Source: The Journal of Thoracic and Cardiovascular Surgery)

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Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis

European Radiology — Thu, 19 Jan 2012 07:00:01 +0100

Conclusion Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer. Key Points • Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen • There is also negative correlation between ADCs and vascular endothelial growth factor • ADC values may contribute to the treatment of oesophageal cancer. Content Type Journal ArticleCategory GastrointestinalPages 1-6DOI 10.1007/s00330-011-2359-0Authors Tomoyoshi Aoyagi, Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670 JapanKiyohiko Shuto, Department of Frontier Surgery, Graduate School of M...

Cyclooxygenase Isoenzyme-2 and Vascular Endothelial Growth Factor are Associated with Poor Prognosis in Esophageal Adenocarcinoma

Journal of Gastrointestinal Surgery — Thu, 19 Jan 2012 06:48:23 +0100

Conclusions This is the first study that evaluated the prognostic value and correlation of COX-2 and VEGF expression in a large and homogenous population of patients with EAC. No correlation between COX-2 and VEGF expression was found. Both markers were expressed in EAC and were associated with poor prognosis. The findings support the use of COX-2 and VEGF inhibitors in future clinical studies. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s11605-011-1814-1Authors M. J. D. Prins, Department of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsR. J. J. Verhage, Department of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsF. J. W. ten Kate, Department o...

Extensive Mediastinal Lymphadenectomy During Minimally Invasive Esophagectomy: Optimal Results from a Single Center

Journal of Gastrointestinal Surgery — Thu, 19 Jan 2012 06:48:20 +0100

Conclusions Extensive mediastinal lymphadenectomy during minimally invasive esophagectomy is a feasible procedure for EC patients. It is technically safe and oncologically adequate in experienced hands, and improves the accuracy of tumor staging. Further study is required to discuss its long-term prognostic value for esophagus cancer patients. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s11605-012-1824-7Authors Yaxing Shen, Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, ChinaYi Zhang, Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, ChinaLijie Tan, Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai,...

High risk oesophageal cancer gene discovered

EurekAlert! - Medicine and Health — Thu, 19 Jan 2012 05:00:00 +0100

(Queen Mary, University of London) New research from Queen Mary, University of London has uncovered a gene which plays a key role in the development of oesophageal cancer. (Source: EurekAlert! - Medicine and Health)

Toenail trace element status and risk of Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study

International Journal of Cancer — Thu, 19 Jan 2012 05:00:00 +0100

This study aimed to examine toenail trace element status and risk of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). Toenail clippings from each hallux were obtained from 638 participants of the FINBAR study (Factors Influencing the Barrett's Adenocarcinoma Relationship) comprising 221 healthy controls, 98 reflux oesophagitis, 182 BO and 137 OAC cases. The concentrations of eight toenail trace elements were determined using Instrumental Neutron Activation Analysis. Using multivariable adjusted logistic regression analysis, odds ratios (OR) and 95% CIs were calculated within tertiles of trace element concentrations. A two‐fold increased risk of BO was observed, but not OAC, amongst individuals in the highest tertile of toenail zinc status OR 2.21 (95% CI 1.11‐4.40). A hi...

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Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery

Journal of Cancer Research and Therapeutics — Thu, 19 Jan 2012 05:00:00 +0100

Conclusion : Preoperative conditions like hypertension and higher creatinine levels predict development of cervical anastomotic leakage after esophageal cancer surgery. Postoperative consequences accompanying leakage include pulmonary complication and prolonged hospitalization. (Source: Journal of Cancer Research and Therapeutics)

Airway Complications After Covered Stent Placement for Malignant Esophageal Stricture: Special Reference to Radiation Therapy

American Journal of Roentgenology — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSION. Esophagorespiratory fistula is much more common than airway narrowing as an airway complication. The rate of complications increases significantly in association with radiation therapy among patients with malignant esophageal stricture. Clinicians need to be aware of earlier airway complications and poorer prognosis among patients who undergo radiation therapy before placement of an esophageal stent than in patients who undergo radiation after stent placement. (Source: American Journal of Roentgenology)

New Strategy Detects High-Risk Barrett's Esophagus PatientsNew Strategy Detects High-Risk Barrett's Esophagus Patients

Medscape Medical News Headlines — Wed, 18 Jan 2012 13:21:17 +0100

New optical biomarkers might more accurately detect patients with Barrett's esophagus who are at high risk of developing esophageal cancer. Medscape Medical News (Source: Medscape Medical News Headlines)

Esophageal Cancer May Be Caused By Migration Of Cancer-Causing Stomach Cells

Health News from Medical News Today — Wed, 18 Jan 2012 10:00:00 +0100

A new study is providing clues that may answer a decades-old question about the cells that give rise to a particularly lethal form of esophageal cancer. The research, published by Cell Press in the January 17th issue of the journal Cancer Cell, links inflammation and bile acid reflux with migration of cancer-causing stomach cells into the esophagus and may help guide future strategies for early therapeutic intervention. Esophageal adenocarcinoma is a cancer of the esophagus that is associated with acid reflux disease and Barrett esophagus (BE)... (Source: Health News from Medical News Today)

Stomach Cells and Esophageal Cancer

Medical Headlines From Ivanhoe.com — Wed, 18 Jan 2012 05:00:00 +0100

(Ivanhoe Newswire)-- Experiments involving mice help provide new insight into what may cause a lethal form of esophageal cancer. (Source: Medical Headlines From Ivanhoe.com)

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Blood Test Shows Promise in Spotting Pancreatic Cancers Early

The Doctors Lounge - Health News — Wed, 18 Jan 2012 02:45:27 +0100

Another study suggests a similar test for those at risk for esophageal tumors (Source: The Doctors Lounge - Health News)

Erratum

Gastrointestinal Endoscopy — Tue, 17 Jan 2012 22:04:55 +0100

In the article, “Outcomes of T1b esophageal adenocarcinoma patients,” by Tian et al., which appeared in the December 2011 issue of GIE (Gastronintest Endosc 2011;74:1201-6), there was an error in the Abstract and in the list of abbreviations. The correct version of each follows. (Source: Gastrointestinal Endoscopy)

Study reveals origins of esophageal cancer

ScienceDaily Headlines — Tue, 17 Jan 2012 19:40:40 +0100

Researchers have identified the critical early cellular and molecular events that give rise to a type of esophageal cancer called esophageal adenocarcinoma, the fastest-rising solid tumor in the United States. The findings challenge conventional wisdom regarding the origin and development of this deadly cancer and its precursor lesion, Barrett's esophagus, and highlight possible targets for new clinical therapies. (Source: ScienceDaily Headlines)

New Technique to Pinpoint Esophageal CancerNew Technique to Pinpoint Esophageal Cancer

Medscape Today Headlines — Tue, 17 Jan 2012 13:26:28 +0100

A new technique that uses a fluorescent lectin to highlight areas of high-grade dysplasia and cancer in the esophagus could improve current screening procedures for patients with Barrett's esophagus. Medscape Medical News (Source: Medscape Today Headlines)

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Sevoflurane reduces severity of acute lung injury possibly by impairing formation of alveolar oedema

Clinical and Experimental Immunology — Tue, 17 Jan 2012 11:17:00 +0100

In this study, the clinical importance of tumor‐infiltrating CD45RO+ memory T cells was investigated in human oesophageal squamous cell carcinoma (OSCC). CD45RO+ T cells were evaluated by immunohistochemistry in primary OSCC tumors from 105 patients. Patients were classified into two groups as CD45RO+hi or CD45RO+lo based on the number of cells positively stained for CD45RO. No significant difference was observed between CD45RO status and several clinicopathological prognostic factors. However, the postoperative overall and disease‐free survivals for patients of CD45RO+hi were significantly better than CD45RO+lo patients. Furthermore, there were significant correlations of CD45RO status in the primary tumor with postoperative lymph node and pulmonary recurrence, suggesting that memory ...

Fluorescent spray 'detects oesophageal cancer'

NHS News Feed — Tue, 17 Jan 2012 08:30:00 +0100

Conclusion This small study has developed a fluorescently tagged molecule that can help identify areas of Barrett’s oesophagus that have progressed towards becoming cancerous. This is an early study with limitations, including the following: This was a small study, which only tested the technique in sections of oesophagus from four patients. The study only looked at oesophageal samples that had been removed from the body, although the researchers did try to replicate how the oesophagus would be examined in real life. The fluorescent molecule binds more strongly to normal tissue and less strongly to abnormal tissue. The researchers note that an ideal marker for cancerous tissue would usually work in the opposite way: binding to abnormal tissue but not normal tissue. This study...

Sugar Used To Halt Esophageal Cancer In Its Tracks

Health News from Medical News Today — Tue, 17 Jan 2012 08:00:00 +0100

Scientists working at the Medical Research Council have identified changes in the patterns of sugar molecules that line pre-cancerous cells in the esophagus, a condition called Barrett's dysplasia, making it much easier to detect and remove these cells before they develop into esophageal cancer. These findings, reported in the journal Nature Medicine, have important implications for patients and may help to monitor their condition and prevent the development of cancer... (Source: Health News from Medical News Today)

Study reveals origins of esophageal cancer

EurekAlert! - Medicine and Health — Tue, 17 Jan 2012 05:00:00 +0100

(Columbia University Medical Center) Researchers at Columbia University Medical Center have identified the critical early cellular and molecular events that give rise to a type of esophageal cancer called esophageal adenocarcinoma, the fastest-rising solid tumor in the United States. The findings, published online today in Cancer Cell, challenge conventional wisdom regarding the origin and development of this deadly cancer and its precursor lesion, Barrett's esophagus, and highlight possible targets for new clinical therapies. (Source: EurekAlert! - Medicine and Health)

InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers

JNCI — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers. (Source: JNCI)

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Predictive factors for radiation pneumonitis in oesophageal cancer patients treated with chemoradiotherapy without prophylactic nodal irradiation.

The British Journal of Radiology — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions: Our study demonstrated that severe RP was also developed in patients treated with the minimal radiation field. Stage IV and the dosimetric factors were identified as independent predictive factors for symptomatic RP in oesophageal cancer patients treated with CRT without prophylactic nodal irradiation. PMID: 22253344 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

Cancer Cell — Tue, 17 Jan 2012 00:00:00 +0100

Michael Quante, Govind Bhagat, Julian A. Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles J. Lightdale, Anil K. Rustgi, Timothy C. Wang. Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression o.... (Source: Cancer Cell)

Fluorescent spray that can catch throat cancer early offers hope to 8,000 Britons diagnosed each year

the Mail online | Health — Mon, 16 Jan 2012 13:02:46 +0100

A throat spray has been developed to spot cancer of the oesophagus at an early stage, offering hope to thousands of Britons who are diagnosed every year with the disease. (Source: the Mail online | Health)

Fluorescent dye could detect early oesophageal cancer

Medical Research Council Press Releases — Mon, 16 Jan 2012 12:00:00 +0100

A fluorescent dye that can be sprayed onto the gullet could be used to detect oesophageal cancer earlier and spare patients unnecessary treatment. (Source: Medical Research Council Press Releases)

Researchers use sugar to halt esophageal cancer in its tracks

ScienceDaily Headlines — Sun, 15 Jan 2012 20:09:09 +0100

Scientists have identified changes in the patterns of sugar molecules that line pre-cancerous cells in the esophagus, a condition called Barrett’s dysplasia, making it much easier to detect and remove these cells before they develop into esophageal cancer. These findings have important implications for patients and may help to monitor their condition and prevent the development of cancer. (Source: ScienceDaily Headlines)

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Concomitantly elevated serum matrix metalloproteinases 3 and 9 can predict survival of synchronous squamous cell carcinoma of the upper aero‐digestive tract

Molecular Carcinogenesis — Sun, 15 Jan 2012 10:40:26 +0100

This study tested if serum MMP levels correlate with clinical features and predict survival for HNSCC, ESCC, and synchronous SCC. One hundred and thirty patients with SCCs in upper aero‐digestive tract (70 ESCC, 20 HNSCC, and 40 synchronous SCC) and 74 healthy controls were assessed for serum MMP‐3, ‐7, and ‐9 titers by enzyme‐linked immunosorbent assay. The titers were validated to their correlations to clinical features and survival rates of the different SCC groups. Patients with SCCs had significantly higher serum MMP‐3, ‐7, and ‐9 titers than the controls (P < 0.001) but there was no difference among the three SCC groups. Based on the optimal MMP cut‐off values by ROC curve, elevated MMP‐3 and MMP‐9, but not MMP‐7, correlated with distant metastasis and ...

Researchers use sugar to halt esophageal cancer in its tracks

EurekAlert! - Medicine and Health — Sun, 15 Jan 2012 05:00:00 +0100

(New York University) Scientists working at the Medical Research Council have identified changes in the patterns of sugar molecules that line pre-cancerous cells in the esophagus, a condition called Barrett's dysplasia, making it much easier to detect and remove these cells before they develop into esophageal cancer. These findings have important implications for patients and may help to monitor their condition and prevent the development of cancer. (Source: EurekAlert! - Medicine and Health)

Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas.

Clinical Cancer Research — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSIONS: HER2 positivity was shown in 17% of resected EACs and associated with reduced tumor aggressiveness. EACs with BE had nearly twice the odds of being HER2 positive and, within this subgroup, HER2 positivity was independently associated with improved survival. Clin Cancer Res; 18(2); 546-54. ©2012 AACR. PMID: 22252257 [PubMed - in process] (Source: Clinical Cancer Research)

Racial Disparities in Esophageal Cancer Outcomes

Journal of Surgical Research — Sat, 14 Jan 2012 22:30:12 +0100

(Source: Journal of Surgical Research)

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Gastrointestinal Cancers in Young Survivors of Lymphoma: Implications for Earlier Screening

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:56 +0100

This study sought to determine if patients diagnosed under the age of 40 would benefit from earlier screening for gastrointestinal (GI) malignancies. Methods: Analysis of the Surveillance Epidemiology and End Results (SEER) database using data accrued from 1973-2008. Patients younger than 40 years old who were diagnosed with Hodgkin's (HL) or Non-Hodgkin's Lymphoma (NHL) between 1973 and 1993 were included. the incidence of various GI cancers in these patients was obtained. Standardized incidence ratios using the SEERStat software were generated to identify more frequent and early age-onset second malignancies in this cohort. Results: In this time period, 27,339 HL patients and 138,474 NHL patients were identified, among whom 8,892 HL and 7,606 NHL patients were less than 40 years old. The...

Prognostic Impact of Perineural, Blood and Lymph Vessel Invasion for Esophageal Cancer Patients

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:06 +0100

Conclusions: This retrospective study demonstrates the prognostic significance of LVI for EAC patients and supports its inclusion into the TNM staging system of the UICC. Determination of LVI might help to identify those patients who profit from adjuvant treatment after surgical resection. (Source: Journal of Surgical Research)

Quality Measures for Assessing Hospital Mortality: Evaluation Using Instrumental Variable Analysis

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:01 +0100

Conclusions: Composite measures forecast large differences in hospital mortality with surgery. Based on instrumental variable analysis, these differences in mortality are not due to unmeasured hospital differences in patient severity of illness, indicating that composite measures can be useful quality indicators for public reporting and pay-for-performance. (Source: Journal of Surgical Research)

Pre-Operative Core Muscle Cross-Sectional Area is Associated With Long-Term Survival Following Tri-Modality Management of Esophageal Carcinoma

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:57 +0100

(Source: Journal of Surgical Research)

Evaluation of TNFAIP3 Gene Polymorphisms as Prognostic Markers in Complete Resected Only Surgically Treated Esophageal Cancer

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:57 +0100

(Source: Journal of Surgical Research)

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Integrated Genomic Analysis of Esophageal Adenocarcinoma Identifies DNA Copy Number Changes and Related Gene Expression Alterations That are Associated With Survival

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:57 +0100

(Source: Journal of Surgical Research)

Recurrence Patterns and Predictors of Recurrence After Neoadjuvant Chemoradiation (CRT) Followed by Surgery for Esophageal Cancer

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:55 +0100

(Source: Journal of Surgical Research)

Hereditary diffuse gastric cancer: The always-forgotten Meckel’s diverticulum

Surgery — Sat, 14 Jan 2012 22:27:59 +0100

The aim of prophylactic surgery is to remove as much of the at-risk tissue as possible to reduce the chances of developing cancer in the at risk tissue. This point is made clear by Pandalai et al in their study of patients with CDH1 mutations, where total gastrectomy is performed to excise all the at risk gastric mucosa. For this reason, partial gastrectomy is contraindicated in these patients, and the total gastrectomy is performed with a resection line across the distal esophagus to ensure no gastric cardia mucosa is left behind. (Source: Surgery)

Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin.

World Journal of Gastroenterology : WJG — Sat, 14 Jan 2012 05:00:00 +0100

CONCLUSION: The combinations of curcumin, EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts, these drugs also inhibited phosphorylated Erk1/2, c-Jun and COX-2 expression. PMID: 22253518 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Assessment of DNA Damage after Photodynamic Therapy Using a Metallophthalocyanine Photosensitizer

Clinical and Developmental Immunology — Fri, 13 Jan 2012 11:20:46 +0100

Photodynamic therapy (PDT) is a chemotherapeutic approach that utilizes a bifunctional reagent, a photosensitizer (PS) that localizes to the target tissue relative to the surrounding tissue and is toxic when exposed to laser light. PDT rapidly induces cell death, inflammatory and immune reactions, and damage of the microvasculature. DNA damage results from a variety of factors including UV-light, X-rays, ionizing radiation, toxins, chemicals, or reactive oxygen species. The aim of this study was to determine the effect of PDT as well as the influence of presensitization leading to the adaptive response (AR) on the integrity of DNA. Lung (A549), breast (MCF-7), and esophageal (SNO) cancer cells and Zn sulfophthalocyanine as PS with irradiation conditions of 10 J/cm2 at 636 nm ...

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Patterns of operative mortality following esophagectomy

Diseases of the Esophagus — Fri, 13 Jan 2012 05:00:00 +0100

SUMMARYEsophagectomy has one of the highest mortality rates among all surgical procedures. We investigated the type and frequency of complications associated with perioperative mortality after esophagectomy. We performed a retrospective review of all perioperative deaths following esophagectomy for esophageal cancer at the Mayo Clinic, Rochester from 1993 through 2009. Of 1522 esophagectomies, perioperative mortality occurred in 45 (3.0%). The majority who died were male (82%); median age was 72 years (range 46–92). The median age‐adjusted Charlson comorbidity score was 6. Twenty‐three (51%) underwent neoadjuvant chemoradiotherapy. The type of esophagectomy was transthoracic in 27 patients (60%), transhiatal in eight (18%), tri‐incisional in seven (16%), left thoracoabdominal in on...

Meat Consumption, Cooking Methods, Mutagens, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay.

Nutrition and Cancer — Fri, 13 Jan 2012 05:00:00 +0100

Authors: Stefani ED, Deneo-Pellegrini H, Ronco AL, Boffetta P, Correa P, Aune D, Mendilaharsu M, Acosta G, Silva C, Landó G, Luaces ME Abstract The role of meat in squamous cell carcinoma of the esophagus (ESCC) has been considered conflictive. For this reason, we decided to conduct a case-control study on meat consumption and ESCC. Data included 234 newly diagnosed and microscopically examined ESCC and 2,020 controls with conditions not related to tobacco smoking nor alcohol drinking and without changes in their diets. We studied total meat, red meat, beef, lamb, processed meat, poultry, fish, total white meat, liver, fried meat, barbecued meat, boiled meat, heterocyclic amines, nitrosodimethylamine, and benzo[a]pyrene in relation with the risk of ESCC. Red meat, lamb, and boiled...

Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study.

BMC Cancer — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions: An increased focus on prevention and early diagnosis, especially in deprived areas and in males, is required to improve outcomes for these cancers. Improved recording of tumour site, stage and morphology and the evaluation of focused early diagnosis programmes are also needed. The poor long-term survival reinforces the need for early detection and multidisciplinary care. (Source: BMC Cancer)

The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells

British Journal of Cancer AOP — Thu, 12 Jan 2012 05:00:00 +0100

Authors: M J Nyhan, T R O'Donovan, B Elzinga, L C Crowley, G C O'Sullivan & S L McKenna (Source: British Journal of Cancer AOP)

The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma

British Journal of Cancer AOP — Thu, 12 Jan 2012 05:00:00 +0100

Authors: S Dutta, J J Going, A B C Crumley, Z Mohammed, C Orange, J Edwards, G M Fullarton, P G Horgan & D C McMillan (Source: British Journal of Cancer AOP)

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Successful closure of pharyngo-cutaneous and phayryngo-tracheal fistulas using removable hypopharyngeal stent after laryngectomy for laryngeal carcinoma

The Saudi Journal of Gastroenterology — Thu, 12 Jan 2012 05:00:00 +0100

Mohamad A Eloubeidi, Desiree E Morgan, William R Carroll, Lawrence F JohnsonSaudi Journal of Gastroenterology 2012 18(1):62-67Placement of removable stents to close pharyngo-cutaneous and tracheo-pharyngeal fistulas after laryngectomy has not been reported before. This case presents the feasibility of removable esophageal stent in closing pharyngo-cutaneous and tracheo-pharyngeal fistulas after laryngectomy for laryngeal cancer. Consecutive patients who underwent placement of removable esophageal stent for closing pharyngo-cutaneous and tracheo-pharyngeal fistulas after laryngectomy for laryngeal cancer. Three patients underwent successful stent placement in the hypopharynx. The stents were well tolerated. Patient one had the stent for 14 months, leading to complete healing of the fistula....

Role of the insulin‐like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma

British Journal of Surgery — Thu, 12 Jan 2012 05:00:00 +0100

Conclusion:This study highlighted the association of the IGF axis with visceral obesity, and a potential impact on the biology of oesophageal adenocarcinoma through its receptor. Targeting the IGF axis may have a rationale in future studies. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma.

The British Journal of Surgery — Thu, 12 Jan 2012 05:00:00 +0100

CONCLUSION: This study highlighted the association of the IGF axis with visceral obesity, and a potential impact on the biology of oesophageal adenocarcinoma through its receptor. Targeting the IGF axis may have a rationale in future studies. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 22241325 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)

Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Cancer Biology and Therapy — Thu, 12 Jan 2012 04:00:22 +0100

In conclusion, we suggest that PRDX1 and PRDX6 are key targets in the process of dioscin-induced apoptosis that involves intracellular elevated ROS. PMID: 22231406 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)

Differences in sensitivity to tumor-specific CTLs between primary and metastatic esophageal cancer cell lines derived from the same patient

Surgery Today — Wed, 11 Jan 2012 06:58:09 +0100

Conclusion The metastatic tumor cells displayed lower regulated ICAM-1 expression levels and were less sensitive to specific CTLs. ICAM-1 downregulation may be one mechanism by which tumor cells escape immunologic surveillance. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00595-011-0083-7Authors Yoshinobu Ichiki, Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JapanTakeshi Hanagiri, Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JapanMitsuhiro Takenoyama, Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JapanTetsuro Baba, Second Department ...

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Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma

Diseases of the Esophagus — Wed, 11 Jan 2012 05:00:00 +0100

SUMMARYIn the light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate‐binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (ESCC) was investigated, and their prognostic values were evaluated. Paraffin‐embedded tissue sections of 110 ESCC patients were investigated using Immunohistochemistry. The association of CD133 and ABCG2 expression with clinicopathologic characteristics was analyzed by χ2 test. Survival analysis was carried out using Kaplan–Meier method and Cox proportional hazards model. CD133 and ABCG2 expression were detected in 27.3% and 15.5% of ESCC patients, respectively. The presence of CD133‐positive cancer cells was associated with tumor cell ...

Subdiaphragmatic bronchogenic cyst of the esophagus masquerading as a metastatic lymph node of coexisting advanced gastric cancer

Esophagus — Tue, 10 Jan 2012 17:00:52 +0100

Abstract Esophageal bronchogenic cysts are rare bronchopulmonary foregut malformations, and those located in the abdominal cavity are particularly rare. Esophageal cysts are typically found incidentally; an exact preoperative diagnosis of bronchogenic cyst is difficult, and surgical resection is generally recommended. Here, we report a case in which a subdiaphragmatic bronchogenic cyst of the esophagus coexisted with advanced gastric cancer. A 44-year-old man was referred for the treatment of gastric cancer. A preoperative examination revealed a mass on the right side of the esophagogastric junction that was preoperatively diagnosed as a metastatic lymph node. Intraoperative exploration revealed that the mass had protruded from the abdominal esophageal wall, and was diagno...

Prevalence of esophageal cancer during the pretreatment of hypopharyngeal cancer patients: Routinely performed esophagogastroduodenoscopy and FDG-PET/CT findings.

Acta Oncologica — Tue, 10 Jan 2012 05:00:00 +0100

Conclusions. The prevalence of esophageal cancer during the pretreatment of HPC patients was 51.5%; this prevalence was higher than that in previous reports. We believe that the increasing proportion of superficial lesions (82.8%) detected using iodine staining and EGD may have led to the relatively high prevalence. FDG-PET/CT detected only 20.7% of the esophageal cancers, although FDG-PET/CT is capable of detecting unexpected primary malignant tumors other than esophageal cancer. PMID: 22229748 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy.

Brain, Behavior, and Immunity — Tue, 10 Jan 2012 05:00:00 +0100

Authors: Wang XS, Williams LA, Krishnan S, Liao Z, Liu P, Mao L, Shi Q, Mobley GM, Woodruff JF, Cleeland CS Abstract Although evidence of inflammation and fatigue has been noted in cancer survivors, whether inflammation is linked to the expression of fatigue and other symptoms arising from concurrent chemoradiation therapy (CXRT) has not been well studied. Patients undergoing CXRT for locally advanced colorectal or esophageal cancer (n=103) reported multiple symptoms weekly via the MD Anderson Symptom Inventory (MDASI) from start of therapy. Serum samples were collected weekly to examine changes in inflammatory markers (interleukin [IL]-6, IL-8, IL-10, IL-1 receptor antagonist (IL-1RA), vascular endothelial growth factor (VEGF), and soluble receptor 1 for tumor necrosis factor (sTN...

Mucinous Adenocarcinoma of Stomach

Diagnostic Imaging — Mon, 09 Jan 2012 12:00:00 +0100

Clinical History: An 84-year-old male patient, known case of HTN and dyslipidemia, complaining of dysphasia for three months. Anorexia and vomiting. Diagnosed as esophageal adenocarcinoma outside for evaluation. (Source: Diagnostic Imaging)

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Promoter Methylation Regulates Cigarette Smoke‐Stimulated Cyclooxygenase‐2 Expression in Esophageal Squamous Carcinoma Cells

Chinese Journal of Digestive Diseases — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion These findings suggest that the promoter methylation may be one of the mechanisms regulating COX‐2 expression in ESCC in response to stimulation of CSE.© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases)

A symptomatic esophageal mucocele after esophageal bypass surgery

Esophagus — Fri, 06 Jan 2012 16:47:36 +0100

Abstract We encountered a case of esophageal mucocele with progressive respiratory symptoms which originated from an excluded thoracic esophagus that was closed at both the proximal and distal ends, and which occurred 24 years after esophageal bypass surgery for a spontaneous esophageal rupture. The patient was a 64-year-old male who was treated by a temporary external drainage for relief of his symptoms without subsequent complete resection of the mucocele via thoracotomy, because of the high surgical risks associated with such a procedure. Four-hundred and fifty milliliters of waste removed during the initial external drainage showed no signs of inflammation or malignancy, suggesting that the reason this excluded esophagus was a symptomatic mucocele was not the obse...

Impaired Quality Of Life: A Warning Signal After Oesophageal Cancer Surgery

Health News from Medical News Today — Fri, 06 Jan 2012 08:00:00 +0100

A new study published in the Journal of Clinical Oncology shows that most patients who survive for at least five years after oesophageal cancer surgery recover an average quality of life. However, quality of life deteriorates significantly for one in six patients to a level that remains much lower than the average population in the five years after surgery. This suggests, say the researchers, that hospitals must be better at identifying this patient group. Globally, oesophageal cancer is the eighth most common form of cancer... (Source: Health News from Medical News Today)

Correlation Between the Pretherapeutic Neutrophil to Lymphocyte Ratio and the Pathologic Response to Neoadjuvant Chemotherapy in Patients With Advanced Esophageal Cancer

World Journal of Surgery — Fri, 06 Jan 2012 06:45:03 +0100

Conclusions Our study is the first to demonstrate that the pretherapeutic NLR can be used as a predictor for chemosensitivity of thoracic esophageal cancer. Preoperative evaluation based on the clinical N stage and NLR may be easily used in routine clinical practice. Content Type Journal ArticlePages 1-6DOI 10.1007/s00268-011-1411-1Authors Hiroshi Sato, Division of Esophageal Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777 JapanYasuhiro Tsubosa, Division of Esophageal Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777 JapanTatsuyuki Kawano, Department of Esophago-Gastric Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan Journal World...

Cancer-related deaths continue to decline in US

Guardian Unlimited Science — Thu, 05 Jan 2012 20:13:24 +0100

American Cancer Society's annual report cites advances in cancer screening and treatment for falling numbersCancer death rates are continuing to fall, dropping by 1.8% per year in men and 1.6% per year in women between 2004 and 2008, according to the American Cancer Society's annual report on cancer statistics released on Wednesday.Advances in cancer screening and treatment have prevented more than a million total deaths from cancer since the early 1990s, according to the report.But the influential cancer group said new cases of seven less-common cancers rose in the past decade, suggesting more could be done in America's 40-year war on cancer.This year, the cancer group projects 1,638,910 people will be newly diagnosed with cancer and 577,190 people will die from it."The big news this year...

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Impaired Quality Of Life, A Warning Signal After Oesophageal Cancer Surgery

Health News from Medical News Today — Thu, 05 Jan 2012 09:00:00 +0100

Time selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: The possible role of nuclear factor kappaB signaling pathway

International Journal of Cancer — Thu, 05 Jan 2012 05:00:00 +0100

In this study, we intended to mimic this human nutritional trial to determine the chemopreventive effects of Ve/Se supplementation at the early or late stage of esophageal carcinogenesis in rats. Esophageal squamous cell carcinoma (ESCC) was induced in F344 rats with N‐nitrosomethylbenzylamine (NMBzA) (0.35 mg/kg BW, s.c., 3 times/wk for 5 weeks). The rats were maintained on a modified AIN‐93M diet with low levels of Ve/Se or supplemented with high levels of Ve/Se at different stages. At Week 25, the number and volume of visible tumors, the numbers of dysplasia and ESCC were significantly lower in rats of supplementation during the early stage (Group C) or during the entire experimental period (Group E), but not during the late stage (Group D). Ve/Se supplementation at early stage also...

Some esophageal cancer survivors suffer

Health News - UPI.com — Thu, 05 Jan 2012 04:21:29 +0100

STOCKHOLM, Sweden, Jan. 4 (UPI) -- Most patients who survive at least five years after esophageal cancer surgery recover an average quality of life, but 1-in-6 do not, Swedish researchers say. (Source: Health News - UPI.com)

Dynamic Variation of Transmitral Mid-Diastolic Flow in Constrictive Pericarditis

Journal of the American College of Cardiology — Wed, 04 Jan 2012 18:27:40 +0100

A 47-year-old man presented with dyspnea and anasarca, and was found to have jugular venous distension, pleural effusions, and ascites. Three years earlier, he had undergone surgery and radiotherapy for esophageal cancer. Computed tomography revealed pericardial thickening (A). Echocardiography revealed a septal bounce (Online Video 1), plethoric inferior vena cava, dynamic variation in hepatic vein (B) and transmitral flow velocities and prominent mid-diastolic flow or L-wave during expiration (C). Radical pericardiectomy was performed for relief of constrictive pericarditis. Post-operatively, respirophasic Doppler variation was not observed (D). (Source: Journal of the American College of Cardiology)

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Salvage radiotherapy in patients with recurrent esophageal carcinoma

Strahlentherapie und Onkologie — Wed, 04 Jan 2012 16:50:43 +0100

Conclusion RT is feasible and effective in the management of recurrent esophageal carcinoma, especially for relief of symptoms. Toxicity is in an acceptable range. The outcome of REC is poor; however, long-term survival of patients with recurrent esophageal carcinoma after radiochemotherpy might be possible, even with a previous history of radiotherapy in the initial treatment. If re-irradiation of esophageal carcinoma is contemplated, three-dimensional conformal techniques and a minimum total dose of 45 Gy are recommended. Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s00066-011-0023-xAuthors K. Fakhrian, Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, GermanyN. Gami...

Mayo Clinic Surgeons Advance Esophagectomy Treatment

News from Mayo Clinic — Wed, 04 Jan 2012 15:09:23 +0100

Surgeons at Mayo Clinic in Arizona have perfected a new procedure that offers a less invasive option in the treatment of esophageal cancer. (Source: News from Mayo Clinic)

Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer

Journal of Cancer Research and Clinical Oncology — Wed, 04 Jan 2012 06:59:31 +0100

Conclusions Our data suggested that polymorphisms of Prdx 1, 2 and 6 were not associated with esophageal cancer. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1119-5Authors Bo Zhang, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaKai Wang, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaGang He, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaXinying Guan, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaBotao Liu, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaYangbo Liu, Department of Medical Genetics, Third Military Medical University, Chongqing, ChinaYun Ba...

Impaired quality of life: A warning signal after oesophageal cancer surgery

EurekAlert! - Medicine and Health — Wed, 04 Jan 2012 05:00:00 +0100

(Karolinska Institutet) A new study published in the Journal of Clinical Oncology shows that most patients who survive for at least five years after oesophageal cancer surgery recover an average quality of life. However, quality of life deteriorates significantly for one in six patients to a level that remains much lower than the average population in the five years after surgery. This suggests, say the researchers, that hospitals must be better at identifying this patient group. (Source: EurekAlert! - Medicine and Health)

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Cancers with increasing incidence trends in the United States: 1999 through 2008

CA: A Cancer Journal for Clinicians — Wed, 04 Jan 2012 05:00:00 +0100

AbstractDespite declines in incidence rates for the most common cancers, the incidence of several cancers has increased in the past decade, including cancers of the pancreas, liver, thyroid, and kidney and melanoma of the skin, as well as esophageal adenocarcinoma and certain subsites of oropharyngeal cancer associated with human papillomavirus (HPV) infection. Population‐based incidence data compiled by the North American Association of Central Cancer Registries were used to examine trends in incidence rates from 1999 through 2008 for the 7 cancers listed by sex, age group, race/ethnicity, and stage at diagnosis. Joinpoint regression was used to calculate average annual percent changes in incidence rates (1999‐2008). Rates for HPV‐related oropharyngeal cancer, esophageal adenocarcin...

Many 'healthy snacks' are high in calories

NHS News Feed — Tue, 03 Jan 2012 16:30:00 +0100

It is the time of year when research about diet and exercise makes a big splash in the headlines, but today the Daily Mail warned that dieters should steer clear of seemingly healthy dips and spreads that are actually high in calories. The newspaper highlighted warnings that hummus, which is widely thought to be healthy, has a surprisingly high calorie content. Despite its high fat and energy content, a recent survey of Britons showed that two-thirds of people underestimate the number of calories in the chickpea dip. The survey was commissioned by the World Cancer Research Fund (WCRF), which says that people can still be confused about the calorie content of everyday foods, which can affect weight and therefore cancer risk. The WCRF says that the situation is not helped by the application ...

Radiation Sensitivity of Esophageal Adenocarcinoma: The Contribution of the RNA-Binding Protein RNPC1 and p21-Mediated Cell Cycle Arrest to Radioresistance.

Radiation Research — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Hötte GJ, Lennon NL, Reynolds JV, Maher SG Abstract Radiation combined with chemotherapy (neo-CRT) is increasingly the standard of care for the treatment of esophageal cancer either as neoadjuvant therapy in multimodal protocols or as primary therapy. Unfortunately, ∼60% of patients demonstrate little or no response to neo-CRT. Accordingly, understanding the molecular mechanisms of resistance to therapy may underpin significant advances through the identification of nonresponders either before or early in treatment. We previously identified the RNPC1 gene, which is important in stabilizing p21, as being upregulated in the tumors of esophageal cancer patients who had a poor response to neo-CRT. We hypothesize that RNPC1 contributes to resistance to radiation therapy thro...

Locally advanced esophageal adenocarcinoma: Response to neoadjuvant chemotherapy and survival predicted by ([18F])FDG-PET/CT.

Acta Oncologica — Mon, 02 Jan 2012 05:00:00 +0100

Conclusion. Our results support previous results showing that ([18F])FDG-PET/CT can distinguish a group of patients with worse prognosis after neoadjuvant chemotherapy in adenocarcinoma of the esophagus or esophagogastric junction. This information could offer a new independent preoperative marker of prognosis. PMID: 22208782 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Modeling the risk of esophageal squamous cell carcinoma and squamous dysplasia in a high risk area in iran.

Archives of Iranian Medicine — Sun, 01 Jan 2012 05:00:00 +0100

CONCLUSION: Our models were able to discriminate between ESCC cases and controls in about 77%, and between individuals with and without squamous dysplasia in about 70% of the cases. Using risk factors to predict individual risk of ESCC or squamous dysplasia still has limited application in clinical practice, but such models may be suitable for selecting high risk individuals in research studies, or increasing the pretest probability for other screening strategies. PMID: 22208438 [PubMed - in process] (Source: Archives of Iranian Medicine)

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Gastrointestinal, Hepatobiliary, Pancreatic, and Iron-Related Diseases in Long-Term Survivors of Allogeneic Hematopoietic Cell Transplantation

Seminars in Hematology — Sun, 01 Jan 2012 05:00:00 +0100

Gastrointestinal and hepatobiliary problems in the second year after allogeneic hematopoietic cell transplant (HCT) are usually a continuation of symptoms of protracted acute graft-versus-host disease (GVHD), chronic GVHD, medication side effects, and infection related to immune suppression. As time passes, as tolerance develops, and as immunity improves, the frequency and severity of these problems wane, but new problems involving the gut and liver may arise, sometimes insidiously and sometimes decades after the transplant. Examples are esophageal strictures related to chronic GVHD, gallstones, cirrhosis caused by chronic hepatitis C, secondary malignancy, and rare cases of pancreatic atrophy. One very common complication of transplantation, iron overload, is often associated with substan...

Growth in the Use of PET for Six Cancer Types After Coverage by Medicare: Additive or Replacement?

Journal of the American College of Radiology : JACR — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Several years after its introduction, PET continued to grow rapidly, with evidence that it is replacing BS. Growth of PET occurred without evidence of a decline in body CT. About half of PET use occurred shortly after body CT, suggesting an additive or final arbiter role. (Source: Journal of the American College of Radiology : JACR)

Bone marrow micrometastases in esophageal carcinoma: a 10‐year follow‐up study

Diseases of the Esophagus — Sun, 01 Jan 2012 05:00:00 +0100

SUMMARYDetection of bone marrow micrometastases (BMMs) in patients with esophageal carcinoma may indicate a metastatic phenotype. We assessed if the presence of BMMs had adverse prognostic significance in a 10‐year follow‐up study. Patients undergoing surgery for esophageal cancer were prospectively recruited between February 1999 and August 2000. Bone marrow aspirates were obtained from the iliac crest of patients under general anesthesia at the time of surgery. Immunocytochemical analysis using anticytokeratin antibodies CAM 5.2 and AE1/AE3 was undertaken to determine the presence of BMMs. Union International Contre le Cancer staging was recorded for all patients. Patient follow‐up was completed over a 10‐year period through analysis of the Northern Ireland Cancer Registry. Forty...

[Endoscopic and surgical resection of mucosal adenocarcinoma in Barrett's esophagus : Comparison at two high-volume centers].

Der Chirurg — Sun, 01 Jan 2012 05:00:00 +0100

[Endoscopic and surgical resection of mucosal adenocarcinoma in Barrett's esophagus : Comparison at two high-volume centers]. Chirurg. 2012 Jan;83(1):72-4 Authors: Haeder L, Jähne J PMID: 22246076 [PubMed - in process] (Source: Der Chirurg)

Barrett's oesophagus: raising awareness in heartburn sufferers

Trends in Urology, Gynaecology and Sexual Health — Sun, 01 Jan 2012 05:00:00 +0100

AbstractBarrett's oesophagus is of particular relevance to men – almost twice as many men as women develop the condition, and of these men, three times as many go on to develop cancer. It is therefore particularly important that men are aware of the risk factors outlined here. Copyright © 2012 John Wiley & Sons (Source: Trends in Urology, Gynaecology and Sexual Health)

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Posterior mediastinal lymph node dissection using the pneumomediastinum method for esophageal cancer

Esophagus — Sat, 31 Dec 2011 16:49:15 +0100

Abstract Although posterior mediastinal lymph node metastases are often observed in patients with esophageal cancer, their complete resection via a right thoracic approach is difficult and carries a risk of complications. We have developed a novel procedure for en-bloc dissection of the posterior mediastinal lymph nodes using the pneumomediastinum method. The patient was a 48-year-old female with middle thoracic esophageal cancer. A computed tomography scan showed a posterior mediastinal lymph node 1 cm in diameter. After division of the gastrosplenic ligament by hand-assisted laparoscopic surgery, the esophageal hiatus was opened, and carbon dioxide was introduced into the mediastinum. The anterior and left sides of the distal esophagus were separated, and a swollen ...

The influence of pre‐diagnostic demographic and lifestyle factors on oesophageal squamous cell carcinoma survival

International Journal of Cancer — Sat, 31 Dec 2011 05:00:00 +0100

AbstractDemographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of oesophageal squamous cell carcinoma (OSCC), however little is known about the effect of these factors on survival. We included all 301 patients with incident OSCC, recruited into a population‐based case‐control study of oesophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow‐up for all‐cause mortality was 6.4 years. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pre‐treatment AJCC tumour stage, treatment and presence of co‐morbidities. 213 pa...

Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis

Liver International — Fri, 30 Dec 2011 05:00:00 +0100

ConclusionsThe diagnostic accuracy of ARFI liver and spleen was comparable to TE and Fibrotest for the detection of complications in patients with cirrhosis. (Source: Liver International)

Study: Obesity increases risk of esophageal and gastric adenocarcinoma

HemOncToday.com — Thu, 29 Dec 2011 14:56:00 +0100

O’Doherty MG. Gut. doi:10.1136/gutjnl-2011-30055 (Source: HemOncToday.com)