MedWorm: Gallbladder Cancer

Liver resection: a regional hospital experience

ANZ Journal of Surgery — Sat, 20 Mar 2010 00:00:00 +0100

Conclusion: Resection provides the best hope of cure for patients with primary or secondary hepatic malignancy. With adequate expertise, liver resections can be performed safely in a regional hospital. (Source: ANZ Journal of Surgery)

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Periampullary and Duodenal Neoplasms in Neurofibromatosis Type 1: Two Cases and an Updated 20-Year Review of the Literature Yielding 76 Cases

Journal of Gastrointestinal Surgery — Fri, 19 Mar 2010 06:52:09 +0100

Conclusions These results underscore the importance of a thorough evaluation for tumors in NF1 patients with gastrointestinal symptoms, as well as subsequent surgical management when findings suggest a tumor in the periampullary region, as resection remains the mainstay of treatment. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s11605-009-1123-0Authors Daniel Relles, Thomas Jefferson University and the Jefferson Pancreas, Biliary, and Related Cancer Center Department of Surgery Philadelphia PA USAJennie Baek, Thomas Jefferson University and the Jefferson Pancreas, Biliary, and Related Cancer Center Department of Surgery Philadelphia PA USAAgnieszka Witkiewicz, Thomas Jefferson University and the Jefferson Pancreas, Biliary, and Related Cancer Cente...

Are histological alterations observed in the gallbladder precancerous lesions?

Clinics — Fri, 12 Mar 2010 14:39:55 +0100

CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. (Source: Clinics)

Efficacy and safety of capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated pancreatic, gallbladder, and bile duct carcinoma

Journal of Cancer Research and Clinical Oncology — Fri, 12 Mar 2010 06:48:45 +0100

Conclusion In all, the DocMitoCape regimen exhibited a favorable safety profile and a high rate of tumor stabilizations in patients with pre-treated gallbladder, bile duct and pancreatic carcinoma. It might be considered after failure of standard regimens in these types of cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0843-6Authors Jens Kruth, Universitätsmedizin Mannheim, Ruprecht-Karls-Universität Heidelberg III. Medizinische Klinik, Hämatologie und Onkologie Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyJohanna Nissen, Universitätsmedizin Mannheim, Universität Heidelberg Institut für Klinische Radiologie und Nuklearmedizin Theodor-Kutzer-Ufer 1-3 68167 Mannheim GermanyThomas Ernst, Universitätsmedizin Mannheim, Ruprecht-...

Precise Preoperative Imaging and Adequate Oncologic Resection is Most Important in Achieving Long-Term Prognosis in Gallbladder Cancer

World Journal of Surgery — Tue, 02 Mar 2010 10:00:19 +0100

Content Type Journal ArticleDOI 10.1007/s00268-010-0508-2Authors Ulrich K. Fetzner, University of Cologne Department of General-, Visceral- and Cancer Surgery Cologne GermanyKlaus L. Prenzel, University of Cologne Department of General-, Visceral- and Cancer Surgery Cologne GermanyHakan Alakus, University of Cologne Department of General-, Visceral- and Cancer Surgery Cologne GermanyArnulf H. Hölscher, University of Cologne Department of General-, Visceral- and Cancer Surgery Cologne GermanyDirk L. Stippel, University of Cologne Department of General-, Visceral- and Cancer Surgery Cologne Germany Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

Mortality after Chronic Hepatitis B Virus Infection: A Linkage Study Involving 2 Million Parous Women from Taiwan

The Journal of Infectious Diseases Latest Issue — Fri, 26 Feb 2010 21:50:17 +0100

Conclusions. Our study found an excess risk of death due to both liver‐specific and non–liver‐related causes for HBsAg‐positive women in Taiwan. Effective prevention and treatment of hepatitis B virus infection is an important public health priority. (Source: The Journal of Infectious Diseases Latest Issue)

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The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma

Cancer — Wed, 24 Feb 2010 00:00:00 +0100

In this study, the authors assessed the activity and safety of this combination regimen in patients with advanced BTA.PEFG (cisplatin 40 mg/m2 and epirubicin 40 mg/m2 on Day 1; gemcitabine 600 mg/m2 on Days 1 and 8; and 5-fluorouracil [FU] 200 mg/m2 daily as a continuous infusion) was administered to chemotherapy-naive patients who had a cytologic or histologic diagnosis of locally advanced or metastatic BTA, aged [le]75 years, and a performance status (PS) >60 either until they had evidence progressive disease or for a maximum of 6 months. Tumor size was assessed every 2 months during treatment.Between May 1999 and December 2005, 37 patients (62% metastatic) who had a median age of 62 years and a median PS of 90 received the PEFG regimen at the authors' institution. Primary tumor sites we...

Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry

Surgical Endoscopy — Tue, 23 Feb 2010 07:09:02 +0100

Conclusions The wedge-resection technique combined with lymph node dissection may be the surgical strategy of choice in T1 tumor cases. For T2 tumors, IVb/V resection combined with lymph node dissection of the hepatoduodenal ligament appears to be the minimum volume of resection required. More radical procedures are needed for tumors infiltrating the serosa or beyond. Content Type Journal ArticleDOI 10.1007/s00464-010-0914-4Authors Thorsten Oliver Goetze, Ketteler-Krankenhaus Department of Surgery Lichtenplattenweg 85 63071 Offenbach am Main GermanyVittorio Paolucci, Ketteler-Krankenhaus Department of Surgery Lichtenplattenweg 85 63071 Offenbach am Main Germany Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)

Gallbladder cancer: role of laparoscopy in the management of potentially resectable tumors

Surgical Endoscopy — Tue, 23 Feb 2010 07:08:19 +0100

Conclusions Laparoscopy may be employed in the management of patients with early forms of gallbladder cancer undergoing reoperation. Although the presence of adhesions may result in inadequate exploration, there is a subset of patients for whom it is possible to perform a complete exam. Furthermore, laparoscopic lymphadenectomy and gallbladder bed resection is a promising technique in well-selected patients. Content Type Journal ArticleDOI 10.1007/s00464-010-0925-1Authors Xabier de Aretxabala, Clinica Alemana Santiago Department of Surgery Av Vitacura 5951 Vitacura, Santiago ChileJorge Leon, Clinica Alemana Santiago Department of Surgery Av Vitacura 5951 Vitacura, Santiago ChileJuan Hepp, Clinica Alemana Santiago Department of Surgery Av Vitacura 5951 Vitacura, San...

Metastatic renal clear cell carcinoma to the gallbladder

Kidney Cancer Association — Fri, 19 Feb 2010 20:51:46 +0100

Renal cell carcinoma is the most lethal of all urologic malignancies with a high metastatic potential. Approximately 25% of patients present with stage IV disease and up to 40% of patients have disease recurrence after nephrectomy. Computed Tomography is an important imaging modality for initial diagnosis and restaging of this patient population. Although extremely rare, metastatic clear cell renal carcinoma has been reported to metastasize to the gallbladder.02/20/2010 (Source: Kidney Cancer Association)

Is Laparoscopic Surgery Feasible for Early Gallbladder Cancer?

Medscape Medical News Headlines — Wed, 17 Feb 2010 16:59:01 +0100

In selected patients with suspected early-stage gallbladder carcinoma, laparoscopic surgery is a safe and feasible approach, Korean physicians report in the February Archives of Surgery. Reuters Health Information (Source: Medscape Medical News Headlines)

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Planned Laparoscopic Approach for Early-Stage Gallbladder Cancer: The Glass Is One-Third Full: Comment on "Laparoscopic Approach for Suspected Early-Stage Gallbladder Carcinoma" [Invited Critique]

Archives of Surgery — Mon, 15 Feb 2010 20:50:40 +0100

(Source: Archives of Surgery)

K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis

Journal of Gastroenterology — Mon, 15 Feb 2010 18:00:10 +0100

Conclusions Significant K-ras mutations were frequently detected in the major duodenal papilla and gastric and colonic mucosa of AIP patients. AIP patients may have risk factors for gastric and colonic cancer, but the mechanisms of K-ras mutation and its clinical implications are not clear. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-010-0211-yAuthors Terumi Kamisawa, Tokyo Metropolitan Komagome Hospital Department of Internal Medicine 3-18-22 Honkomagome, Bunkyo-ku Tokyo 113-8677 JapanShin-Ichirou Horiguchi, Tokyo Metropolitan Komagome Hospital Department of Pathology Tokyo JapanYukiko Hayashi, Tokyo Metropolitan Komagome Hospital Department of Pathology Tokyo JapanXiaoqing Yun, Division of Clinical Dev...

Leiomyoma of the gallbladder: a case report with review of the literature and discussion of the differential diagnosis

Journal of Clinical Pathology — Fri, 12 Feb 2010 10:25:41 +0100

Mesenchymal neoplasms of the gallbladder are rare, and most represent sarcomas of various histological types. To our knowledge, only a few patients with multiple Epstein–Barr virus (EBV)-associated smooth muscle tumours of the gallbladder in the setting of immunodeficiency have been reported in the English literature, but no single case of conventional leiomyoma has been well documented to date. A case of gallbladder leiomyoma in a healthy 34-year-old woman is described here. The tumour was found incidentally on a routine ultrasound examination and was removed by simple cholecystectomy. The patient is alive and well at last follow-up, 6 months after surgery. Histology and immunohistochemistry were consistent with a benign smooth muscle neoplasm that is very similar to conventional ut...

Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study

Investigational New Drugs — Thu, 11 Feb 2010 11:49:26 +0100

Conclusions Cetuximab administered at 400 mg/m2 IV as a loading dose with weekly maintenance dose of 400 mg/m2 is feasible and well tolerated. There was no direct correlation of the grade of rash with dose in this group of patients with heterogenous solid tumors. Content Type Journal ArticleCategory PHASE I STUDIESDOI 10.1007/s10637-010-9396-4Authors Cheryl Ho, British Columbia Cancer Agency Vancouver BC CanadaRandeep Sangha, Cross Cancer Institute Edmonton AB CanadaLaurel Beckett, University of California Davis Campus Sacramento CA USAMichael Tanaka, University of California Davis Campus Sacramento CA USADerick H. Lau, University of California Davis Campus Sacramento CA USADaniel B. Eisen, University of California Davis Campus Sacramento CA USARachel A. Burich, University ...

Latest updates to UK DUETS

Wed, 10 Feb 2010 12:42:33 +0100

We have recently added the following uncertainties to UK DUETS: Bariatric surgery for non-alcoholic steatohepatitis in obese patients Chinese herbal medicines for induction of remission in advanced or late gastric cancer Optimal duration of pegatheron plus ribavirin therapy for chronic hepatitis C in patients with HIV Peginterferon plus ribavirin versus no treatment for chronic hepatitis C in patients with HIV Photodynamic therapy using 5-ALA versus porfimer sodium for Barrett's oesophagus Radiofrequency ablation for Barrett's oesophagus and Barrett's dysplasia Radiofrequency ablation versus surgical resection for oligometastatic hepatic metastases of colorectal cancer Radiofrequency ablation versus surgical resection for resectable hepatic metastases of colorectal cancer Radiofrequency ab...

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Current Management of Gallbladder Carcinoma.

The Oncologist — Wed, 10 Feb 2010 00:00:00 +0100

Authors: Zhu AX, Hong TS, Hezel AF, Kooby DA Gallbladder cancer (GBC) represents the most common and aggressive type among the biliary tree cancers (BTCs). Complete surgical resection offers the only chance for cure; however, only 10% of patients with GBC present with early-stage disease and are considered surgical candidates. Among those patients who do undergo "curative" resection, recurrence rates are high. There are no established adjuvant treatments in this setting. Patients with unresectable or metastatic GBC have a poor prognosis. There has been a paucity of randomized phase III data in this field. A recent report demonstrated longer overall survival with gemcitabine in combination with cisplatin than with gemcitabine alone in patients with advanced or metastatic BTCs. Molecular...

CANLIV: The Hepatobiliary Cancers Foundation To Host 1st Annual Biliary Tract-Gallbladder Cancer Research Symposium

Health News from Medical News Today — Fri, 05 Feb 2010 03:00:00 +0100

CanLiv: The Hepatobiliary Cancers Foundation in partnership with The Cholangiocarcinoma Foundation will host the 1st Annual Biliary Tract-Gallbladder Cancer Research Symposium on Friday, May 7, 2010 at the American Society of Clinical Oncologists (ASCO) headquarters in Alexandria, Virginia. The Symposium will engage scientists, clinical researchers, government partners and the patient advocacy community from across the globe in developing a strategic plan to accelerate clinical and translational research to advance treatment of gallbladder and biliary tract cancers... (Source: Health News from Medical News Today)

CANLIV: The Hepatobiliary Cancers Foundation To Host 1st Annual Biliary Tract-Gallbladder Cancer Research Symposium

Cancer / Oncology News From Medical News Today — Fri, 05 Feb 2010 03:00:00 +0100

Heal yourself in 15 days - You are what you absorb (part three)

NaturalNews.com — Mon, 01 Feb 2010 07:00:00 +0100

This article continues part three of the 15-part article series called Heal Yourself in 15 Days. In part two, we explored your innate healing potential and saw how powerful your self-healing abilities really are (http://www.naturalnews.com/028060_self_healing_immune_system.html). Here in part three, we look at a powerful principle of nutrition: You aren't what you eat; you are what you ABSORB.Many people suffer from poor digestion. In fact, you might say that most people aren't able to absorb the nutrients they swallow, so they remain in a state of nutritional starvation even though they're taking supplements that would otherwise be quite helpful.These people tend to scratch their heads, wondering why all the nutrients they're swallowing aren't having the positive effects they had hoped fo...

Pharmacological evaluation of analgesic effects of the cholecystokinin(2) receptor antagonist z-360 in mouse models of formalin- and cancer-induced pain.

Biological and Pharmaceutical Bulletin — Mon, 01 Feb 2010 00:00:00 +0100

This study was attempted to elucidate the analgesic efficacy of Z-360 in mice. Oral administration of Z-360 (30-300 mg/kg) showed a dose-dependent inhibitory effect on the late phase of nociceptive responses to formalin. YF476, another CCK(2) receptor antagonist, was without effects at 1 and 10 mg/kg. In contrast, the CCK(1) receptor antagonist devazepide inhibited the nociceptive responses to formalin. In a mouse model of cancer pain, significant anti-allodynic effect of Z-360 was observed after single and repeated oral administration of 100 and 300 mg/kg doses. Anti-allodynic effect was also observed after repeated administration of devazepide. Combined single treatment with morphine and Z-360 caused an increase inhibition of pain-related responses in the pain models produced by formalin...

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[Histopathologic Analysis of Adenoma and Adenoma-related Lesions of the Gallbladder.]

Korean J Gastroenter... — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently. Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis. PMID: 20168058 [PubMed - in process] (Source: Korean J Gastroenter...)

Elevated CA 19-9 portends poor prognosis in patients undergoing resection of biliary malignancies

HPB: official journal of the International Hepato Pancreat Biliary Association — Wed, 27 Jan 2010 00:00:00 +0100

Conclusions: Elevated pre-operative CA 19-9 levels were found to be independent predictors of poor survival after attempted resection for biliary tree malignancies. It is recommended that CA19-9 be routinely measured prior resection. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Liver Resection Is Associated with Prolonged Survival for Non-Metastatic Gallbladder Cancer: A 10 Year Review

Journal of Surgical Research — Mon, 25 Jan 2010 16:42:17 +0100

Introduction: Gallbladder cancer is a relatively rare cancer in the United States and is often associated with poor prognosis. We reviewed our experience with treating gallbladder cancer and attempted to identify if demographic, tumor, or surgical factors affected survival in our patient population. Methods: We performed a chart review of the cancer registry of 2 large academic hospitals to identify patients with gallbladder cancer between 1999 and 2007. Demographic information, patient and tumor factors, and survival outcomes were collected. We analyzed the patient population for the impact of patient factors and surgical therapy on survival outcome. Results: Our patient database consisted of 68 patients, 52 of which were women (76%). The ethnic distribution was 37% Hispanic, 34% Caucasia...

Proximal Cholangiocarcinoma: Tumor Depth Predicts Outcome

Journal of Surgical Research — Mon, 25 Jan 2010 16:41:31 +0100

The objective of the current study was to examine the accuracy of the AJCC staging system for proximal cholangiocarcinoma. In turn, we sought to determine whether depth of tumor invasion was a more accurate predictor of prognosis in patients with resected proximal cholangiocarcinoma. Methods: Between 1987 and 2004, 297 patients who underwent surgical resection of cholangiocarcinoma were identified from a prospective, single-institution hepato-pancreato-biliary database. Of these 297 patients, 85 (27%) had a proximal cholangiocarcinoma and had pathologic slides available for re-review to measure depth of tumor invasion. Data on demographic, clinical, tumor-related and pathologic factors were collected and analyzed using univariate and multivariate models. Tumor depth was determined by measu...

Cholangiocarcinoma: Update and future perspectives

Digestive and Liver Disease — Mon, 25 Jan 2010 00:00:00 +0100

Abstract: Cholangiocarcinoma is commonly considered a rare cancer. However, if we consider the hepato-biliary system a single entity, cancers of the gallbladder, intra-hepatic and extra-hepatic biliary tree altogether represent approximately 30% of the total with incidence rates close to that of hepatocellular carcinoma, which is the third most common cause of cancer-related death worldwide. In addition, cholangiocarcinoma is characterized by a very poor prognosis and virtually no response to chemotherapeutics; radical surgery, the only effective treatment, is not frequently applicable because late diagnosis. Biomarkers for screening programs and for follow-up of categories at risk are under investigation, however, currently none of the proposed markers has reached clinical application. Fo...

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Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.

World Journal of Gastroenterology : WJG — Thu, 21 Jan 2010 00:00:00 +0100

CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women. PMID: 20082485 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

The chronic gastrointestinal manifestations of Chagas disease

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer. (Source: Clinics)

Successful treatment of a resistance trigeminal neuralgia patient by acupuncture

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

Chronic thrombosed abdominal aortic aneurysms: a report on three consecutive cases and literature review

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

Multiple perforations along the transverse colon as a rare presentation of intestinal behcet's disease: a case report

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

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Three-dimensional rotational angiography in murine models: a technical note

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

Expression of hypoxia-inducible factor-1 alpha (HIF-1α) in patients with the gallbladder carcinoma

International Journal of Clinical Oncology — Fri, 15 Jan 2010 18:00:41 +0100

Conclusion Expression of HIF-1α was correlated with the poor prognostic indicators, such as lymph node metastasis and venous invasion. Therefore, HIF-1α could serve as an auxiliary parameter for predicting malignant behavior for gallbladder carcinomas. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0011-7Authors Erdenebulgan Batmunkh, The University of Tokushima Graduate School Department of Surgery, Institute of Health Biosciences 3-18-15 Kuramoto-cho Tokushima 770-8503 JapanMitsuo Shimada, The University of Tokushima Graduate School Department of Surgery, Institute of Health Biosciences 3-18-15 Kuramoto-cho Tokushima 770-8503 JapanYuji Morine, The University of Tokushima Graduate School Department of Surgery, Institute of Health Bioscie...

Medical comorbidities predict mortality in women with a history of early stage breast cancer

Breast Cancer Research and Treatment — Fri, 15 Jan 2010 00:44:24 +0100

In conclusion, type 2 diabetes is associated with poor breast cancer prognosis. Given that 85% of deaths were caused by breast cancer, these findings suggest that multiple comorbidities may reduce the likelihood of surviving additional breast cancer events. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0732-3Authors Ruth E. Patterson, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USAShirley W. Flatt, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USANazmus Saquib, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USACheryl L. Rock, ...

Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance.

World Journal of Gastroenterology : WJG — Wed, 13 Jan 2010 18:44:50 +0100

CONCLUSION: Our findings suggest that NVP-AEW541 is active against BTC in vitro and potentiates the efficacy of gemcitabine. PMID: 20066734 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Liver and gallbladder cancer in immigrants to Sweden

European Journal of Cancer — Mon, 11 Jan 2010 00:00:00 +0100

Conclusions: Primary liver cancer was increased in immigrants from endemic regions of hepatitis B virus infection but also from large regions lacking cancer incidence data, North Africa, Asian Arab countries, Turkey and previous Yugoslavia; these are probably intermediary risk regions for this infection. The consideration of these regions as risk areas would justify active diagnostic and vaccination programs. The increase in gallbladder cancer in Chileans and Indians suggests that some persistent damage was inflicted before emigration, characterisation of which will be a challenge for aetiological studies. (Source: European Journal of Cancer)

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Laparoscopic radical cholecystectomy and Roux-en-Y choledochojejunostomy for gallbladder cancer

Surgical Endoscopy — Thu, 07 Jan 2010 16:14:34 +0100

Conclusion The minimally invasive approach to gallbladder cancer is feasible and safe. It should currently be performed in high-volume centers with expertise in both hepatobiliary and minimally invasive surgery. Larger trials are needed to determine whether either the open or laparoscopic approach offers any advantage. Content Type Journal ArticleCategory Dynamic ManuscriptDOI 10.1007/s00464-009-0840-5Authors Andrew A. Gumbs, Fox Chase Cancer Center Department of Surgical Oncology 333 Cottman Avenue, C-308 Philadelphia PA 19111 USAJohn P. Hoffman, Fox Chase Cancer Center Department of Surgical Oncology 333 Cottman Avenue, C-308 Philadelphia PA 19111 USA Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)

Laparoscoendoscopic single-site cholecystectomy and occult gallbladder cancer

Surgical Endoscopy — Thu, 07 Jan 2010 16:13:23 +0100

Content Type Journal ArticleCategory LetterDOI 10.1007/s00464-009-0843-2Authors Pascal Bucher, University Hospital Geneva Department of Surgery 24 rue Micheli-du-Crest 1211 Geneva SwitzerlandFrançois Pugin, University Hospital Geneva Department of Surgery 24 rue Micheli-du-Crest 1211 Geneva SwitzerlandPhilippe Morel, University Hospital Geneva Department of Surgery 24 rue Micheli-du-Crest 1211 Geneva Switzerland Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)

The Loneliness Of Fighting A Rare Cancer [Narrative Matters]

Health Affairs — Tue, 05 Jan 2010 01:16:58 +0100

After her mother is diagnosed with gallbladder cancer, a journalist researches how to help find effective therapies for patients who get rare diseases. (Source: Health Affairs)

Blood sugar and cancer risk

NHS News Feed — Mon, 04 Jan 2010 11:14:00 +0100

Conclusion This large prospective cohort study was well conducted. However, there are several facts that should be considered when interpreting the results. The study included previous smokers. Although the researchers say that smoking status had no effect on their findings, they also state that imprecise or incorrect categorisation of smoking status may have affected the results. The researchers highlight that the different protocols for measuring blood glucose levels may have affected the outcome. Information about the participants’ diet and lifestyle was not available, for example exercise levels, alcohol consumption or the many other genetic and medical risk factors that can also contribute to the risk of cancer. The 5 and 11% risk increases for men and women had only bor...

Ten million Britons at risk from cancer, reveals new research

Guardian Unlimited Science — Sun, 03 Jan 2010 00:06:00 +0100

This study looked at the link between high blood glucose levels such as those found in people with pre-diabetes and the relative risk of both getting cancer and dying from it. It is important, however, not to oversimplify the findings of this study. It would be wrong to conclude that high blood glucose levels alone are causing the increase in cancer cases and deaths. Nor can we say that, by controlling blood glucose levels alone, we could lower the risk of cancer. There are likely to be other factors at work, such as genetics, diet and levels of physical activity, which are all also linked to both cancer and blood glucose levels," said Frame.People could reduce their risk of developing either pre-diabetes or Type 2 diabetes by being more physically active and eating plenty of fruit and veg...

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Excess blood sugar raises cancer risk

Guardian Unlimited Science — Sun, 03 Jan 2010 00:06:00 +0100

Florid xanthogranulomatous cholecystitis masquerading as invasive gallbladder cancer leading to extensive surgical resection.

Indian Journal of Pathology and Microbiology — Fri, 01 Jan 2010 00:00:00 +0100

We present here the clinico-radiologic findings of these cases, techniques which may help differentiate between an XGC and a gallbladder carcinoma and also discuss the management of these cases. PMID: 20090248 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

[Critical reappraisal of cholecystectomy in patients with asymptomatic gallstones for early diagnosis and removal of dysplasia and cancer.]

Korean J Gastroenter... — Fri, 01 Jan 2010 00:00:00 +0100

Conclusions: Extending indication of prophylactic cholecystectomy in patients with asymptomatic GS without polyp to prevent GB dysplasia or cancer beyond the existing indication does not seem to be justifiable in Korea. However, further studies are needed in patients with asymptomatic GS and polyp of any size. PMID: 20098067 [PubMed - in process] (Source: Korean J Gastroenter...)

Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma

Journal of Gastroenterology — Fri, 25 Dec 2009 00:18:53 +0100

Conclusions PET-CT is valuable for detecting regional lymph node involvement and unsuspected distant metastases that are not diagnosed by MDCT. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0188-6Authors Seung Won Lee, Sungkyunkwan University School of Medicine Department of Internal Medicine, Kangbuk Samsung Hospital 108, Pyung-Dong, Jongro-Ku Seoul KoreaHong Joo Kim, Sungkyunkwan University School of Medicine Department of Internal Medicine, Kangbuk Samsung Hospital 108, Pyung-Dong, Jongro-Ku Seoul KoreaJung Ho Park, Sungkyunkwan University School of Medicine Department of Internal Medicine, Kangbuk Samsung Hospital 108, Pyung-Dong, Jongro-Ku Seoul KoreaDong Il Park, Sungkyunkwan University School of ...

Surgical Outcomes and Prognostic Factors for T2 Gallbladder Cancer Following Surgical Resection

Journal of Gastrointestinal Surgery — Wed, 23 Dec 2009 22:59:43 +0100

Conclusions For T2 tumors, radical surgery including lymph node dissection should be performed to achieve R0 resection. Tumors with infiltrative types and suspicious lymph node metastasis in the intraoperative findings were candidates for aggressive surgical management to improve patient survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1132-zAuthors Sae Byeol Choi, Korea University College of Medicine, Korea University Guro Hospital Department of Surgery 80, Gurodong, Guro-gu Seoul KoreaHyung Joon Han, Korea University College of Medicine, Korea University Guro Hospital Department of Surgery 80, Gurodong, Guro-gu Seoul KoreaChung Yun Kim, Korea University College of Medicine, Korea University Anam Hospital Anam-Dong 5-Ga, Seongbuk-...

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New Treatment Reverses Symptoms Of Menopause Without Hormone Therapy

Cancercompass News: Breast Cancer — Wed, 23 Dec 2009 00:00:00 +0100

It is estimated that 41 million women in the United States and 250 million women worldwide experience chronic and sometimes debilitating symptoms of menopause. Hormone-replacement therapy (HRT) has been a common pharmaceutical remedy, but a surge of recent studies has shown HRT increases a woman's risk of elevated blood pressure, endometrial and breast cancers, stroke, blood clots and gallbladder disease. (Source: Cancercompass News: Breast Cancer)

In-hospital mortality after resection of biliary tract cancer in the United States

HPB: official journal of the International Hepato Pancreat Biliary Association — Tue, 15 Dec 2009 00:00:00 +0100

Objective: To assess perioperative mortality following resection of biliary tract cancer within the U.S.Background: Resection remains the only curative treatment for biliary tract cancer. However, current data on operative mortality after surgical resections for biliary tract cancer are limited to small and single-center studies.Methods: Using the Nationwide Inpatient Sample 1998[ndash]2006, a cohort of patient-discharges was assembled with a diagnosis of biliary tract cancer, including intrahepatic bile duct, extrahepatic bile duct, and gall bladder cancers. Patients undergoing resection, including hepatic resection, bile duct resection, pancreaticoduodenectomy, and cholecystectomy, were retained. The primary outcome measure was in-hospital mortality. Categorical variables were analyzed b...

Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation.

Biochemical Pharmacology — Wed, 09 Dec 2009 00:00:00 +0100

In conclusions, emodin can work as an adjunct to enhance the anti-cancer effect of platinum drugs in gallbladder cancer cells via ROS-related mechanisms. PMID: 20005210 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)

Minimally Invasive Spine Surgery Gains Ground At NewYork-Presbyterian/Columbia

Health News from Medical News Today — Fri, 04 Dec 2009 10:00:00 +0100

Minimally invasive techniques have become standard for many procedures, from the removal of the gallbladder to angioplasty, but the approach is now only beginning to be available to patients with spinal conditions. The surgical team at NewYork-Presbyterian Hospital/Columbia University Medical Center's Spine Center aims to bring the benefits of minimally invasive surgery for patients with intractable back pain, stenosis, spinal deformity, even spinal cancer... (Source: Health News from Medical News Today)

Evaluation of Gallbladder Lipid Level During Carcinogenesis by an Infrared Spectroscopic Method

Digestive Diseases and Sciences — Thu, 03 Dec 2009 12:52:06 +0100

Conclusions Lipids were increased in the plasma membrane during carcinogenesis of the gallbladder; the ratio of intensity (I) 1,460 cm−1/1,398 cm−1 could be a marker to diagnose cancer by FTIR. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1045-4Authors Jiansheng Wang, First Hospital of Xi’an Jiaotong University Department of Surgical Oncology 710061 Xi’an ChinaJia Zhang, First Hospital of Xi’an Jiaotong University Department of Surgical Oncology 710061 Xi’an ChinaWenan Wu, First Hospital of Xi’an Jiaotong University Department of Surgical Oncology 710061 Xi’an ChinaXiaoyi Duan, First Hospital of Xi’an Jiaotong University Department of Surgical Oncology 710061 Xi’an ChinaSicen Wang, Medical School of Xi’an Ji...

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Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.

Pathology, Research and Practice — Thu, 26 Nov 2009 00:00:00 +0100

We describe a tumor combined with LCNEC and adenocarcinoma elements arising in the gallbladder and give a review of the literature. A 68-year-old woman was diagnosed as having gallbladder wall thickening and a hepatic mass. The surgically resected tumor had a dumbbell shape with gallbladder and liver elements. Histological examination revealed LCNEC in the liver and a deep infiltrative portion of the gallbladder, as well as a well-differentiated tubular adenocarcinoma in the mucosa of the gallbladder. The pseudoglandular structures of LCNEC were marked in the transitional area. Immunoreactivities for carcinoembryonic antigen and CA19-9 as well as for chromogranin A and synaptophysin were detected in the LCNEC element. High p53-protein expression and high proliferative activity estimated by...

[Endoscopic Treatment of a Pediatric Patient with Acute Pancreatitis Caused by Anomalous Union of Pancreaticobiliary Duct Combined with Incomplete Pancreatic Divisum.]

Korean J Gastroenter... — Wed, 25 Nov 2009 00:00:00 +0100

Authors: Park JB, Park JB, Seo JH, Park JY, Park SW, Song SY, Chung JB, Bang S The most common causes of acute pancreatitis are microlithiasis and alcohol. In pediatrics, anomalies in pancreaticobiliary system should be considered as possible causes. Among many anomalies, pancreas divisum associated with anomalous pancreaticobiliary ductal union (APBDU) is very rare. APBDU is associated with acute pancreatitis, choledochal cyst, and gallbladder cancer. Pancreas divisum is also a well known cause of acute recurrent pancreatitis. In adult cases with such conditions, the role of endoscopic management including sphincterotomy or stenting through the Santorini duct is well documented. However, it is still controversial to perform endoscopic retrograde cholangiopancreatography in pediatrics....

Combo Treatment Beneficial in Biliary-Tract Cancer Study

MedlinePlus Health News — Mon, 23 Nov 2009 14:00:00 +0100

Adding drug to chemo regimen may improve patient outcomes, research suggests Source: HealthDay Related MedlinePlus Topics: Bile Duct Diseases, Cancer Chemotherapy, Gallbladder Diseases (Source: MedlinePlus Health News)

Study Finds Obesity to be Major Player in Cancer Development

NaturalNews.com — Mon, 23 Nov 2009 07:00:00 +0100

(NaturalNews) A November 5 report prepared by the American Institute for Cancer Research (AIRC) revealed that over 100,000 people a year develop cancer due to obesity. The study divulged pertinent data indicating a direct correlation between excess body fat and the development and propagation of various types of cancer.Topping the list of obesity-related cancers was endometrial cancer which represents 49% of cases followed by esophageal cancer at 35%. Pancreatic cancer ranked third at 28%, trailed by kidney cancer at 24%, gallbladder cancer at 21%, breast cancer at 17%, and colorectal cancer at 9%.According to Dr. Laurence Kolonel, MD, PhD, Deputy Director of the Cancer Research Center of Hawaii and AICR/WCRF expert panel member, the study's results contain convincing evidence that excess ...

Methotrexate: Gallbladder squamous cell cancer in an elderly patient?: case report

Reactions — Sun, 22 Nov 2009 14:04:51 +0100

(Source: Reactions)

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Is Type 2 Diabetes Mellitus A Risk Factor For Gallbladder, Biliary And Pancreatic Cancer?

Health News from Medical News Today — Fri, 20 Nov 2009 13:00:00 +0100

There are minimal data assessing the relationship between diabetes and gallbladder, biliary and pancreatic cancer. Recent small studies have suggested an elevated risk of pancreatic cancer only in patients with diabetes mellitus (DM). A research article published on November 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team, lead by Dr. (Source: Health News from Medical News Today)

Is Type 2 Diabetes Mellitus A Risk Factor For Gallbladder, Biliary And Pancreatic Cancer?

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 13:00:00 +0100

Obesity and Cancer

Experimental and Clinical Endocrinology and Diabetes — Thu, 19 Nov 2009 14:15:55 +0100

Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precursor” condition such as gallstones. The increased cancer risk in patients with obesity is a neglected topic which deserves more scientific attention. Because of its...

Is type 2 diabetes mellitus a risk factor for gallbladder, biliary and pancreatic cancer?

EurekAlert! - Medicine and Health — Wed, 18 Nov 2009 05:00:00 +0100

(World Journal of Gastroenterology) Presently, type 2 diabetes mellitus (DM) is associated with cardiovascular complications, and also with several cancers. A research group from USA has investigated the association of gallbladder, biliary and pancreatic cancer in hospitalized American veterans with and without type 2 DM. Among patients with type 2 DM, the risk of pancreatic cancer was threefold higher and that for gallbladder and extrahepatic biliary cancer was twofold higher compared to hospitalized patients without DM. (Source: EurekAlert! - Medicine and Health)

Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program

Annals of Diagnostic Pathology — Mon, 16 Nov 2009 15:08:36 +0100

Abstract: Primary neuroendocrine tumors of the gallbladder (GB) and extrahepatic biliary ducts (EHBDs) include carcinoid tumors and small-cell carcinomas (SCCs). They are uncommon, and therefore, little is known about their demographics and clinical course. From National Cancer Institute's Surveillance, Epidemiology, and End Results program (1973-2005), we analyzed the demographics and 10-year relative survival rates of carcinoids and SCCs of the GB and EHBD according to histologic type and stage. There were 119 cases of carcinoid tumors and 54 cases of SCCs in the GB. There were 31 carcinoid tumors and 17 SCCs in the EHBD. The female/male ratios of carcinoids in the GB and EHBD were 2.4 and 1.6, respectively. The ratios for SCC in the GB and EHBD were 2.2 and 1.1, respectively. For the GB...

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Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:47 +0100

CONCLUSION: Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. PMID: 19908334 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma

Cancer Chemotherapy and Pharmacology — Tue, 10 Nov 2009 18:44:50 +0100

In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed. CT scan and ultrasound before the surgery did not show any tumor. After the surgery a Pet scan was positive for a hot-spot in the left colon. The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular. The patient was then submitted to three sections of 1,600 mg/m2 of gemcitabine with intervals of 1 week. Three weeks later he developed severe respiratory distress. A helicoidal CT scan showed diffuse and severe interstitial pneumonit...

Unsuspected Gallbladder Cancer Diagnosed After Laparoscopic Cholecystectomy: Focus on Acute Cholecystitis

World Journal of Surgery — Sat, 07 Nov 2009 07:55:05 +0100

Conclusions The preoperative diagnosis included a high rate of acute and severe acute cholecystitis. Survival was not associated with the presence of AC and bile spillage. Therefore, we suggest that AC may not influence the prognosis of unsuspected gallbladder cancer after LC. Moreover, good tumor differentiation can guarantee favorable survival, even in UGC with AC. Content Type Journal ArticleDOI 10.1007/s00268-009-0279-9Authors Ji Hun Kim, Ajou University Department of Surgery, School of Medicine San-5, Wonchondong, Yeongtonggu Suwon 442-749 KoreaWook Hwan Kim, Ajou University Department of Surgery, School of Medicine San-5, Wonchondong, Yeongtonggu Suwon 442-749 KoreaJin Hong Kim, Ajou University Department of Gastroenterology, School of Medicine San-5, Wonchondon...

Detection of Helicobacter hepaticus in Human Bile Samples of Patients with Biliary Disease

Helicobacter — Wed, 04 Nov 2009 00:00:00 +0100

Conclusion: Helicobacter hepaticus may closely associate with diseases of the liver and biliary tract in humans. (Source: Helicobacter)

A Case of Gallbladder Cancer Arising from the Rokitansky-Aschoff Sinus

Japanese Journal of Clinical Oncology — Mon, 02 Nov 2009 11:24:26 +0100

(Source: Japanese Journal of Clinical Oncology)

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Author's Reply. Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer.

Singapore Medical Journal — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Mishra RN PMID: 19960171 [PubMed - in process] (Source: Singapore Medical Journal)

Comment on: Lifestyle, reproductive factors and risk of gallbladder cancer.

Singapore Medical Journal — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Afifi M PMID: 19960170 [PubMed - in process] (Source: Singapore Medical Journal)

Cholangiocarcinoma may be familial and associated with malignant melanoma

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:51 +0100

We describe a family with familial cancer of the gallbladder and melanoma. Further descriptions may lead to a better delineation of a hereditary component in adenocarcinoma of the gallbladder. (Source: European Journal of Surgical Oncology)

Radical resection for T1b gallbladder cancer: a decision analysis

HPB: official journal of the International Hepato Pancreat Biliary Association — Wed, 14 Oct 2009 23:00:00 +0100

Conclusions: Decision analysis demonstrates that radical resection is associated with increased survival for most patients with T1b gallbladder cancer. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Incidental Gallbladder Cancer Diagnosed Following Laparoscopic Cholecystectomy

World Journal of Surgery — Tue, 13 Oct 2009 08:11:44 +0100

Conclusions Male patients exhibited aggressive tumor characteristics. Laparoscopic cholecystectomy is an adequate treatment for pT1 tumors. For pT2 and pT3 patients, additional radical surgery might be needed to achieve a tumor-free surgical margin, along with lymph node dissection. Content Type Journal ArticleDOI 10.1007/s00268-009-0249-2Authors Sae Byeol Choi, Korea University Guro Hospital Department of Surgery, Korea University Medical Center, Korea University College of Medicine 80, Gurodong, Guro-gu Seoul KoreaHyung Joon Han, Korea University Guro Hospital Department of Surgery, Korea University Medical Center, Korea University College of Medicine 80, Gurodong, Guro-gu Seoul KoreaChung Yun Kim, Korea University Anam Hospital Department of Surgery, Korea Universi...

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First experience of hepatic radioembolization using microspheres labelled with yttrium-90 (TheraSphere): practical aspects concerning its implementation

European Journal of Nuclear Medicine and Molecular Imaging — Sat, 10 Oct 2009 07:02:09 +0100

Conclusion Although sometimes technically difficult, the use of TheraSphere microspheres is a worthwhile therapeutic approach because of the low level exposure of operators and the encouraging rate of response or stabilization. The use of SPECT/CT contributes greatly to helping therapeutic planning, especially in the learning curve or when the angiographic procedure is difficult. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00259-009-1279-6Authors Etienne Garin, Comprehensive Cancer Center Eugène Marquis Department of Nuclear Medicine Rennes FranceYan Rolland, Comprehensive Cancer Center Eugène Marquis Department of Medical Imaging Rennes FranceEveline Boucher, Comprehensive Cancer Center Eugène Marquis Department of Medical Oncology Rennes ...

The role of PET-CT in patients with incidental gallbladder cancer

HPB: official journal of the International Hepato Pancreat Biliary Association — Fri, 09 Oct 2009 23:00:00 +0100

Conclusions: For patients presenting with stage T1b or greater IGC, the use of 18FDG PET-CT will help reduce the number of patients undergoing non-therapeutic re-exploration and may help to determine the likely prognosis. 18FDG PET-CT might be a useful tool for the selection of patients for potentially curative treatment. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma

Cancer Science — Tue, 06 Oct 2009 00:00:00 +0100

In conclusion, this study suggests a possible mechanism by which carcinoma cells but not normal cells are sensitive to SAHA and indicates the efficacy of this new anticancer agent in combination with EZH2 repression in gallbladder carcinoma. (Cancer Sci 2009) (Source: Cancer Science)

New book reveals secret Brazilian Aloe recipe for curing cancer using just three ingredients

NaturalNews.com — Fri, 02 Oct 2009 07:00:00 +0100

(NaturalNews) Living in South America, I often find myself steeped in abundant natural cures for many diseases, including cancer. You can hardly walk out your front door without finding yourself surrounded with natural medicines made by Mother Nature, and it's true across the continent, from Ecuador (where I live) through Peru and Bolivia, and all the way to Brazil.In Brazil, a humble monk named Father Romano Zago has uncovered a powerful yet simple cure for cancer based on just three ingredients... one of them being whole Aloe Arborescens (not just the gel, but the whole leaf, including the skin and the sap). What follows is his explanation of how this Brazilian Aloe cure works to help reverse not just cancer, but several other diseases, too, like obesity and depression. He's compiled thi...

Can aloe vera prevent and cure cancer?

NaturalNews.com — Thu, 01 Oct 2009 07:00:00 +0100

(NaturalNews) If you're looking to prevent cancer, you need to know about aloe vera. More resarch on aloe vera is taking place all around the world as word spreads about its natural healing potential. You'll learn a wealth of information about this in this article.Here, we present a collection of quotes and observations about aloe vera and cancer, documented in some of the best health books ever written. Read and remember these quotes, and feel free to share what you learn here with others who may also need this information.Some clinics have used aloe vera to increase the effectiveness of cancer treatment with the chemotherapy agents cyclophosphamide (Cytoxan, Neosar) and 5-fluorouracil (5-FU). Several studies indicate that aloe vera gel can protect both the immune system and the skin from...

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A case of unresectable gallbladder cancer responding to gemcitabine after metallic biliary stent implantation.

Journal of Nippon Medical School — Thu, 01 Oct 2009 00:00:00 +0100

Authors: Matsutani T, Uchida E, Yokoyama T, Matsushita A, Matsuda A, Sasajima K A 69-year-old woman with a chief complaint of jaundice was referred to our hospital. She underwent exploratory laparotomy under a diagnosis of advanced biliary tract cancer. Histological examination of a biopsy specimen of the gallbladder revealed adenocarcinoma. The tumor was unresectable because of invasion into a wide area of the hepatoduodenal ligament and liver bed. Retrograde transhepatic bile drainage tubes were inserted through the common bile duct into the right and left branches of the intrahepatic bile ducts. After metallic biliary stent implantation, gemcitabine (1,000 mg) was administered intravenously once a week for 2 weeks, followed by 1 week of rest. After 2 courses of chemotherapy, compute...

Managing chronic oedema in the morbidly obese patient.

British Journal of Nursing — Thu, 01 Oct 2009 00:00:00 +0100

This article investigates the financial and health consequences of the rising obesity problem and outlines some of the strategies implemented to halt this trend. The effects and management of chronic oedema in the morbidly obese patient are also presented. PMID: 19966731 [PubMed - in process] (Source: British Journal of Nursing)

Macabre autopsy misdiagnosed mummy's cause of death

Guardian Unlimited Science — Tue, 29 Sep 2009 23:05:14 +0100

A macabre 19th century autopsy of the mummy of a 50-year-old woman named Irtyersenu misdiagnosed her cause of deathThe mysterious death of an Egyptian woman, whose mummy became a public spectacle in Georgian Britain, has been solved by a team of researchers in London.Forensic analysis of tissues taken from the 2,600-year-old corpse has revealed signs of tuberculosis, a disease that was widespread in Egypt.The mummy of Irtyersenu or "lady of the house" became the first to go under the surgeon's knife in an autopsy in 1825, when England was in the grip of mummy mania.The remains were unveiled to a large crowd in a macabre lecture by Dr Augustus Granville who, in a theatrical flourish, lit the room at the Royal Society with candles made from wax scraped from the shrivelled corpse.The examinat...

Macabre autopsy led to misdiagnosis

Guardian Unlimited Science — Tue, 29 Sep 2009 23:05:14 +0100

Cholangiocarcinoma

Journal of Diagnostic Medical Sonography — Tue, 29 Sep 2009 23:00:00 +0100

is a rare, primary cancer of the biliary tree that can be difficult to diagnose with all imaging modalities. The presenting clinical symptoms of nausea, vomiting, and jaundice can be consistent with classic cholecystitis symptoms, increasing the risk of a missed diagnosis. The most often seen risk factor for cholangiocarcinoma is primary sclerosing cholangitis (PSC). In most cases, the initial diagnostic finding is intrahepatic ductal dilatation. Once an actual mass is seen, liver transplantation is the necessary treatment plan because of likely hepatic metastasis. There is a slight recurrence rate of cholangiocarcinoma even in a transplanted liver. A high percentage of cases are treated with only palliative care. This case presents a classic example of cholangiocarcinoma at the porta hep...

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Lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancer

Surgery — Mon, 28 Sep 2009 17:44:49 +0100

Conclusion: LN evaluation is a critical component of radical resection for GB cancer. In the absence of LN evaluation, radical resection provides no benefit over cholecystectomy alone. (Source: Surgery)

An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells

Chemistry Central Journal — Mon, 28 Sep 2009 00:00:00 +0100

Conclusion: It is possible that LD may have some chemotherapeutic potential. However, further studies are required to determine its cytotoxic constituents. (Source: Chemistry Central Journal)

EGFR and HER2 expression in advanced biliary tract cancer.

World Journal of Gastroenterology : WJG — Sat, 26 Sep 2009 09:54:43 +0100

CONCLUSION: Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC, while targeting EGFR may be promising. PMID: 19777609 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening

Cancer Science — Thu, 24 Sep 2009 23:00:00 +0100

Gallbladder cancer (GBC) is a highly fatal malignancy in humans. Genetic alterations in KRAS or TP53 as well as overexpression of ERBB2 have been shown to contribute to the development of certain types of GBC. However, many cases of GBC do not harbor such genetic changes, with other transforming events awaiting discovery. We here tried to identify novel cancer-promoting genes in GBC, with the use of a retroviral cDNA expression library. A retroviral cDNA expression library was constructed from a surgically resected clinical specimen of GBC, and was used to infect 3T3 fibroblasts in a focus formation assay. cDNA incorporated into the transformed foci was rescued by PCR. One such cDNA was found to encode free fatty acid receptor 2 (FFAR2), a G protein-coupled receptor for short-chain fatty a...

Complement Receptor 1 (A3650G RsaI and Intron 27 HindIII) Polymorphisms and Risk of Gallbladder Cancer in North Indian Population

Scandinavian Journal of Immunology — Thu, 24 Sep 2009 00:00:00 +0100

Decreased expression due to genetic variations in complement receptor 1 (CR1) on erythrocytes might result in reduced clearance of immune complexes, conferring interindividual variation for gallbladder cancer (GBC) susceptibility. We studied role of CR1 (A3650G RsaI and Intron 27 HindIII) polymorphisms in gallstone disease and GBC in north Indian population. Study included 185 GBC patients, 185 gallstone patients and 200 controls. Genotyping was done by PCR-RFLP. Result showed GG genotype and G allele of CR1 A3650G RsaI were conferring significant risk for GBC [(P = 0.022; OR = 1.94; 95% CI = 1.1[ndash]3.4) and (P = 0.035; OR = 1.35; 95% CI = 1.0[ndash]3.8) respectively]. Also, comparison of GBC patients with gallstone patients showed increased risk for GBC in presence of GG genotype and G...

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Should the extrahepatic bile duct be resected or preserved in R0 radical surgery for advanced gallbladder carcinoma? Results of a Japanese Society of Biliary Surgery Survey: A multicenter study

Surgery Today — Wed, 23 Sep 2009 05:51:24 +0100

Conclusions Our retrospective questionnaire survey showed that an extrahepatic bile duct resection had no preventive value in some patients with advanced gallbladder carcinoma in comparison to similar patients who had no such bile duct resection. An extrahepatic bile duct resection may therefore be unnecessary in advanced gallbladder carcinoma without a direct infiltration of the hepatoduodenal ligament and the cystic duct. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-3960-6Authors Tatsuo Araida, Tokyo Women’s Medical University Department of Surgery, Institute of Gastroenterology 8-1 Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanRyouta Higuchi, Tokyo Women’s Medical University Department of Surgery, Institute of Gastroenterology 8-1 ...

Incidental Gallbladder Carcinoma Diagnosed During or After Laparoscopic Cholecystectomy

World Journal of Surgery — Thu, 17 Sep 2009 12:41:35 +0100

Conclusions The survival with incidental GC is related to stage, and it validates that a carefully performed LC is adequate treatment for carcinoma in situ, and stage 1a and b cancer. A frozen section examination was helpful but did not provide a definitive diagnosis. Meticulous techniques during LC, including retrieval of the gallbladder in a retrieval bag, may prevent port-site recurrence and intraperitoneal dissemination. Content Type Journal ArticleDOI 10.1007/s00268-009-0218-9Authors Wei-Jie Zhang, 101th Hospital of Chinese People’s Liberation Army Department of General Surgery North Xingyuan Road 214044 Wuxi Jiangsu ChinaGui-Fang Xu, Affiliated Drumtower Hospital of Nanjing University Medical School Department of Gastroenterology 210008 Nanjing ChinaXiao-Ping...

Iliac–hepatic arterial bypass for compromised collateral flow during modified Appleby operation for advanced pancreatic cancer

European Journal of Surgical Oncology — Mon, 14 Sep 2009 16:13:10 +0100

We described a modified Appleby operation for locally advanced distal pancreatic cancer with compromised hepatic collateral flow that needed hepatic arterial revascularization, successfully accomplished by left external iliac–hepatic arterial bypass with Dacron prosthesis. Patient recovery was uneventful and he was discharged on the 10th postoperative day. Postoperative angio-CT disclosed a patent arterial bypass. Patient is well and asymptomatic 13 months after operation. At the time of this writing, postoperative CT scan showed no evidence of disease and CA 19-9 level is normal. There is a well established rationale to perform extended resection of pancreatic carcinomas that compromise vascular structures. Modified Appleby procedure can safely be performed, has oncological advantages t...

The Gerson Therapy: Big Pharma and the AMA Suppress Another Holistic Cancer Cure

NaturalNews.com — Thu, 10 Sep 2009 07:00:00 +0100

ConclusionAs Albert Schweitzer wrote, "Many of his basic ideas have been adopted without having his name connected with them." That was written several years ago. Today, there are those who have used the Gerson protocol to cure their cancer and become alternative cancer treatment gurus, soliciting materials over the Internet.There are also those who have adopted some or most of his techniques in their holistic health practices. His discoveries have spread throughout the alternative healing community. But it's probably best to use a practitioner who has been certified by the Gerson Institute for cancer cases.Fortunately, parts of his methodology can be used by anyone from home. It's to our benefit to explore and utilize Dr. Max Gerson's findings and methods now more than ever. He stated in ...

[Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas.]

Korean J Gastroenter... — Mon, 31 Aug 2009 23:00:00 +0100

Conclusions: IPMN is associated with high incidence of extrapancreatic tumors, particularly gastric and colorectal neoplasms. Upper gastrointestinal endoscopy and colonoscopy should be done, and systemic surveillance for the possible occurrence of other tumors may allow early detection of extrapancreatic tumor in patients with IPMN. PMID: 19844152 [PubMed - in process] (Source: Korean J Gastroenter...)

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Early gallbladder cancer: Is further treatment necessary?

Journal of Surgical Oncology — Sun, 30 Aug 2009 23:00:00 +0100

The goal of this study was to evaluate a series of patients with early gallbladder cancer, focusing on the selection of treatment and the role of Rokitansky Aschoff sinus infiltration.We performed a retrospective analysis of a prospective series of 371 patients with gallbladder cancer. Specimens were reviewed by an independent pathologist to confirm the diagnosis and depth of infiltration and to evaluate the presence of Rokitansky Aschoff sinus involvement.Forty-nine and 45 patients with muscular (pT1b) and mucosal (pT1a) infiltration gallbladder cancer tumors were studied respectively. Simple cholecystectomy was the treatment in all patients, with the exception of 11 patients who underwent further surgery. Rokitansky Aschoff sinus invasion was seen in seven patients with mucosa (pT1a) and...

Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer

Cancer Chemotherapy and Pharmacology — Tue, 25 Aug 2009 16:45:36 +0100

Conclusions Gemcitabine and S-1 combination chemotherapy has promising efficacy and good tolerability in patients with advanced biliary tract cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1115-5Authors Takashi Sasaki, University of Tokyo Department of Gastroenterology, Faculty of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanHiroyuki Isayama, University of Tokyo Department of Gastroenterology, Faculty of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYousuke Nakai, University of Tokyo Department of Gastroenterology, Faculty of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYukiko Ito, Japanese Red Cross Medical Center Department of Gastroenterology Tokyo JapanHirofumi Kogure, Kanto Central Hospital Department of Gas...

[Gallbladder cancer in a regional hospital.]

Cirugia eEspanola — Mon, 17 Aug 2009 23:00:00 +0100

CONCLUSIONS: GBC has a low incidence but it will be found in 1% of cholecystectomies. There is no adjuvant treatment and T-based surgical treatment is the is the only opportunity to reach cure in those patients. A national GBC database would be helpful in the publication of national guidelines for this disease. PMID: 19695566 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)

The epothilone B analogue ixabepilone in patients with advanced hepatobiliary cancers: a trial of the University of Chicago Phase II Consortium

Investigational New Drugs — Tue, 11 Aug 2009 01:37:49 +0100

Conclusion Single agent ixabepilone has limited activity in advanced hepatobiliary cancers. Content Type Journal ArticleCategory PHASE II STUDIESDOI 10.1007/s10637-009-9297-6Authors Halla S. Nimeiri, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center 676 North St. Clair Street, suite 850 Chicago IL 60611 USADeepti A. Singh, University of Chicago Medical Center 5841 S. Maryland Ave., MC 2115 Chicago IL 60637 USAKristen Kasza, University of Chicago 5841 S. Maryland Ave. MC 2007 Chicago IL 60637 USADavid A. Taber, Northern Indiana Cancer Research Consortium 100Navarre Place Suite 5550 South Bend IN 46601 USARafat H. Ansari, Northern Indiana Cancer Research Consortium 100Navarre Place Suite 5550 South Bend IN 46601 USAEverett E. Vokes, Univers...

Value of Routine Histopathologic Examination of Three Common Surgical Specimens: Appendix, Gallbladder, and Hemorrhoid

World Journal of Surgery — Sun, 09 Aug 2009 09:12:31 +0100

Conclusions The routine histopathology examination of the appendix and gallbladder, particularly in cases of empyema and patient’s age over 60 years, is of value for identifying unsuspected conditions requiring further postoperative management. However, routine histopathologic evaluation of the hemorrhoid seems unnecessary. Content Type Journal ArticleDOI 10.1007/s00268-009-0164-6Authors Varut Lohsiriwat, Mahidol University Department of Surgery, Faculty of Medicine Siriraj Hospital Prannok Road Bangkok 10700 ThailandAkkarash Vongjirad, Mahidol University Department of Surgery, Faculty of Medicine Siriraj Hospital Prannok Road Bangkok 10700 ThailandDarin Lohsiriwat, Mahidol University Department of Surgery, Faculty of Medicine Siriraj Hospital Prannok Road Bang...

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Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial

Cancer Chemotherapy and Pharmacology — Mon, 03 Aug 2009 20:40:01 +0100

Conclusions The GEMOX regimen demonstrated a modest antitumor activity and is well tolerated in patients with advanced BTCs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1069-7Authors Joung-Soon Jang, Chung-Ang University College of Medicine Division of Hematology/Oncology, Department of Internal Medicine 224 Heukseok-dong, Dongjak-gu Seoul 156-755 Republic of KoreaHo Yeong Lim, Sungkyunkwan University School of Medicine Divisions of Hematology-Oncology, Department of Medicine, Samsung Medical Center 50 Ilwon-dong, Kangnam-gu Seoul 135-710 Republic of KoreaIn Gyu Hwang, Yong-San Hospital, Chung-Ang University Department of Internal Medicine 65-270 Hanganro 3-ga, Yongsan-gu Seoul 140-757 Republic of KoreaHong Suk Song, Keimyung University S...

Gastric Emptying Function in Patients 5 Years After Pylorus-Preserving Distal Gastrectomy With or Without Preserving Pyloric and Hepatic Branches of the Vagal Nerve for Early Gastric Cancer

World Journal of Surgery — Mon, 03 Aug 2009 05:55:35 +0100

Conclusions There were no significant differences in the postoperative QOL and GET between PPG patients with preserving PHV and those without preserving PHV. Cholecystolithiasis was only found in patients without preserving PHV. Content Type Journal ArticleDOI 10.1007/s00268-009-0147-7Authors Ryouichi Tomita, Nippon Dental University School of Life Dentistry at Tokyo Department of Surgery 2-3-16 Fujimi, Chiyoda-ku Tokyo 102-8158 Japan Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

Uncommon mucosal metastases to the stomach

World Journal of Surgical Oncology — Sun, 02 Aug 2009 23:00:00 +0100

Conclusions: While the accurate recognition of these lesions at endoscopy is fraught with difficulty, pathological awareness of such uncommon metastases in the gastric mucosa is essential for accurate diagnosis and optimal patient management. (Source: World Journal of Surgical Oncology)

Use of Retrieval Bags in Incidental Gallbladder Cancer Cases

World Journal of Surgery — Tue, 28 Jul 2009 06:14:42 +0100

Conclusions According to the registry data, the intraoperative gallbladder perforation results in significant (P = 0.047) prognostic disadvantage and in these cases retrieval bags were used more often (P = 0.001). However, in IGBC cases if intraoperative gallbladder perforation has already happened, the use of retrieval bags had no protective effects. Content Type Journal ArticleDOI 10.1007/s00268-009-0163-7Authors Thorsten Oliver Goetze, Ketteler-Krankenhaus Department of Surgery 63071 Offenbach GermanyVittorio Paolucci, Ketteler-Krankenhaus Department of Surgery 63071 Offenbach Germany Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

Gallbladder cancer

MayoClinic.com Full Feed — Sat, 25 Jul 2009 05:00:00 +0100

— Comprehensive overview covers symptoms, treatment of cancer of the gallbladder. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

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Apply Influence Diagrams for Utility Analysis of Paying the Weight-Reducing Expenses: A Case Study in Taiwan

Journal of Medical Systems — Sat, 25 Jul 2009 04:28:24 +0100

Abstract To effectively control the growth of medical expenditure, Bureau of National Health Insurance (NHI) of Taiwan has taken many measures, including the Reasonable Number of Outpatient Services, Ceiling Price, Global Budgets, Strategic Analysis and the Excellence Plan; however, these measures can only scratch the surface. Due to the change of life style and the deteriorating condition of over-nutrition and obesity, people now have a higher risk of diabetes, hypertension, hyperlipidemia, cardiovascular disease, gallbladder disease, cancer, gout, arthritis, and so on, which leads to higher medical expenditure. Therefore, good civil preventive health care is regarded as the solution of surging medical expenditure. According to NHI’s statistics, the annual medical expen...

Indirect method to estimate specific Hispanic group cancer rates

Cancer Causes and Control — Tue, 21 Jul 2009 00:04:55 +0100

Conclusion The approach yielded reasonable and useful information to explore etiologic differences among the populations, as well as to develop relevant cancer control interventions. However, direct identification of specific Hispanic ethnicity in medical records and annual Census estimates of these populations would be preferable if they ever became available. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9398-8Authors Holly L. Howe, North American Association of Central Cancer Registries, Inc. Springfield IL USAAndrew Lake, Information Management Services, Inc. Silver Spring MD USAMaria J. Schymura, New York State Department of Health Albany NY USABrenda K. Edwards, National Cancer Institute Bethesda MD USA Journal Cancer Causes an...

Metachronous bile duct cancer nine years after resection of gallbladder cancer.

World Journal of Gastroenterology : WJG — Mon, 20 Jul 2009 07:22:12 +0100

We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stage IB). Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type IIIa, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy. The histological diagnosis w...

Autoimmune pancreatitis: An underdiagnosed autoimmune disease with clinical, imaging and serological features.

Autoimmunity Reviews — Fri, 17 Jul 2009 23:00:00 +0100

Authors: Sánchez-Castañón M, de Las Heras-Castaño G, López-Hoyos M Since Sarles et al reported a case of pancreatitis associated with hypergammaglobulinemia, many cases have been described, which led to the current concept of "autoimmune pancreatitis (AIP)". Lymphoplasmacytic infiltration and fibrosis on histology together with elevated IgG levels or the presence of autoantibodies on laboratory examinations supported the concept of AIP. In recent years, based on histological and immunohistochemical examination of various organs of patients with AIP, a novel clinicopathological entity, IgG4-related slerosing disease, has been proposed. AIP is a systemic disease that is characterized by dense infiltration of IgG4-positive plasma cells and T lymphocytes in various...

Update to Patient UK records

Tue, 14 Jul 2009 16:13:17 +0100

We have updated our collection of Patient UK links. Newly added resources are: Acute diarrhoea in children Alcohol and liver disease Aminosalicylates Antacids Antispasmodic drugs Cholecystitis Cirrhosis Constipation in children Dyspepsia in pregnancy Gastroenteritis in children Gilbert's syndrome Haemochromatosis Hepatitis A immunisation Obstetric cholestasis Primary biliary cirrhosis Primary liver cancer Proton pump inhibitors (PPIs) Pyloric stenosis Screening for colorectal (bowel) cancer Sickness and vomiting of pregnancy Stomach (gastric) ulcer Threadworms Toddler's diarrhoea Ulcerative colitis Wilson's disease (Source: Gastroenterology and Liver Diseases Specialist Library - Biliary tree and gallbladder)

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Update to Patient UK records

Tue, 14 Jul 2009 16:13:17 +0100

Screening pharmaceuticals for possible carcinogenic effects: initial positive results for drugs not previously screened

Cancer Causes and Control — Tue, 07 Jul 2009 15:11:49 +0100

Conclusions These preliminary findings suggest that further studies are indicated regarding sulindac, hyoscyamine, nortriptyline, oxazepam, fluoxetine, paroxetine, hydrochlorothiazide, and nifedipine. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9375-2Authors Gary D. Friedman, Kaiser Permanente Medical Care Program Division of Research 2000 Broadway Oakland CA 94612 USANatalia Udaltsova, Kaiser Permanente Medical Care Program Division of Research 2000 Broadway Oakland CA 94612 USAJames Chan, Kaiser Permanente Medical Care Program Pharmacy Outcomes Research Group 1800 Harrison Oakland CA USACharles P. Quesenberry, Kaiser Permanente Medical Care Program Division of Research 2000 Broadway Oakland CA 94612 USALaurel A. Habel, Kaiser Permanente ...

Gallbladder cancer

Tue, 07 Jul 2009 09:54:23 +0100

Last updated 5 February 2008.This section tells you about gallbladder cancer. It includes early symptoms, causes and diagnosis, tests and treatment, living with gallbladder cancer, and current research. (Source: Gastroenterology and Liver Diseases Specialist Library - Biliary tree and gallbladder)

Gallbladder cancer

Tue, 07 Jul 2009 09:54:23 +0100

Gallbladder cancer

Tue, 07 Jul 2009 09:54:23 +0100

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A phase II study of gemcitabine and oxaliplatin (Oxigem) in unresectable gall bladder cancer

Cancer Chemotherapy and Pharmacology — Mon, 06 Jul 2009 16:50:12 +0100

Conclusion This combination of Oxigem effective in unresectable GBC. It may even induce complete pathological response. One-year survival was 20%. There is a need for controlled trial to assess efficacy of this combination. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1055-0Authors Atul Sharma, Dr BRA IRCH, All India Institute of Medical Sciences Department of Medical Oncology New Delhi IndiaBidhu Mohanti, Dr BRA IRCH, All India Institute of Medical Sciences Department of Radiation Oncology New Delhi IndiaVinod Raina, Dr BRA IRCH, All India Institute of Medical Sciences Department of Medical Oncology New Delhi IndiaNootan Shukla, Dr BRA IRCH, All India Institute of Medical Sciences Department of Surgical Oncology New Delhi IndiaSujoy Pal,...

Significance of cytomorphological and microbiological examination of bile collected by endoscopic cannulation of the papilla of vater.

Indian Journal of Pathology and Microbiology — Tue, 30 Jun 2009 23:00:00 +0100

CONCLUSION: Complete microscopic and microbiological examination of bile directly obtained from the common bile duct during endoscopic retrograde cholangiopancreatography yielded good results as fresh samples could be analyzed. It may help in diagnosis of many gallbladder lesions in early stages, thereby reducing the morbidity and mortality. PMID: 19679953 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

Endoscopic Ultrasound May Miss Gallbladder Cancer

Medscape Gastroenterology Headlines — Fri, 26 Jun 2009 20:03:32 +0100

Endoscopic ultrasonography is unable to distinguish neoplastic from non-neoplastic small gallbladder polyps, according to Korean researchers. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

Retraction to: “Laparoscopic cholecystectomy and unsuspected gallbladder cancer” [European Journal of Surgical Oncology 27 (2001) 225–228]

European Journal of Surgical Oncology — Fri, 26 Jun 2009 14:05:42 +0100

This article has been retracted at the request of the Editor-in-Chief. Reason: The Editor-in-Chief and Editorial Team of the EJSO very much regret that it has become necessary to retract this article formally. The journal was recently alerted to the fact that it duplicates substantial sections from an article previously published in Seminars of Surgical Oncology (Box JC, Edge SB. Laparoscopic cholecystectomy and unsuspected gallbladder cancer. Sem Surg Oncol 1999: 16; 327–31). The authors have been contacted but we have not received a satisfactory explanation for the remarkable similarities between the two papers. Their institution will be informed. (Source: European Journal of Surgical Oncology)

Endoscopic ultrasound may miss gallbladder cancer

AuntMinnie.com Headlines — Fri, 26 Jun 2009 07:00:00 +0100

NEW YORK (Reuters Health), Jun 26 - Endoscopic ultrasonography is unable to distinguish neoplastic from non-neoplastic small gallbladder polyps, according to Korean researchers. (Source: AuntMinnie.com Headlines)

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Bacteremia Caused by Dysgonomonas spp.: a Report of Two Cases

Clinical Microbiology Newsletter — Thu, 25 Jun 2009 08:55:48 +0100

The genus Dysgonomonas was recently created by Hofstad et al. () to accommodate a group of fastidious gram-negative, facultative anaerobic, coccobacillus-shaped organisms. This genus constitutes a phylogenetic cluster within the Bacteroides-Prevotella-Porphyromonas group. Three species are included in the genus. Dysgonomonas gadei was first isolated from an infected human gall bladder (). Dysgonomonas capnocytophagoides has been recovered from stool samples, primarily in immunocompromised patients or those with severe underlying diseases (), and from blood and wound and abscess specimens (). This species includes organisms formerly designated CDC group DF-3 (). Dysgonomonas mossii has been described recently by Lawson et al. (). It was isolated from abdominal drainage from a 68-year-old wo...

Epidemiological and molecular mechanisms aspects linking obesity and cancer

Arquivos Brasileiros de Endocrinologia e Metabologia — Thu, 25 Jun 2009 07:36:50 +0100

About 25% of cancer cases globally are due to excess weight and a sedentary lifestyle. These results are alarming, as the world knows a pandemy of obesity and, in consequence, insulin resistance. Obesity may increase risk for various cancers by several mechanisms, including increasing sex and metabolic hormones, and inflammation. Here, we present a review of epidemiological and molecular evidences linking obesity and cancer - particularly colorectal, post-menopausal breast, endometrial, pancreatic, high grade prostate, hepatocellular, gallbladder, kidney and esophageal adenocarcinoma. The expected striking increase in the incidence of cancer in the near future related to obesity turns the knowledge of this field of great impact as it is needed to the development of strategies to prevent an...

Ercp after roux-en-y reconstruction can be carried out using an oblique-viewing endoscope with an overtube

Digestive Endoscopy — Sun, 21 Jun 2009 23:00:00 +0100

Conclusion: The results appear to support the feasibility of using an oblique-viewing endoscope for ERCP in Roux-en-Y reconstruction. Further studies including a large population of patients should be planned to confirm these results. (Source: Digestive Endoscopy)

Gallbladder Polyps And Endoscopic Ultrasonography

Health News from Medical News Today — Thu, 11 Jun 2009 09:00:00 +0100

Although most gallbladder (GB) polyps are benign, some early carcinomas of the GB share the same appearance as benign polyps. Currently, GB polyps larger than 1 cm should be surgically removed because of the increased risk of malignancy. On the other hand, patients with smaller polyps usually require repeated US and follow-up. (Source: Health News from Medical News Today)

Gallbladder Cancer: We Need to Do Better!

Annals of Surgical Oncology — Tue, 09 Jun 2009 15:33:13 +0100

Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0541-2Authors Parul J. Shukla, Tata Memorial Hospital Gastrointestinal Surgical Oncology Mumbai IndiaSavio G. Barreto, Flinders Medical Centre General and Digestive Surgery Adelaide SA Australia Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

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Having Gallstones is the Greatest Risk Factor for Gallbladder Cancer

About.com Cancer — Sun, 07 Jun 2009 00:26:08 +0100

Did you know that the most common and greatest risk factors for developing gallbaldder cancer is having gallstones? Gallstones are deposits of calcium or cholesterol that settle in the gallbladder... (Source: About.com Cancer)

Evolving Treatment Strategies for Gallbladder Cancer

Annals of Surgical Oncology — Thu, 04 Jun 2009 10:10:35 +0100

Abstract Gallbladder cancer is an uncommon cancer that has traditionally been associated with a poor prognosis. In the era of laparoscopic cholecystectomy, incidental gallbladder cancer has dramatically increased and now constitutes the major way patients present with gallbladder cancer. While patients with incidental gallbladder cancer have a better survival than patients with nonincidental gallbladder cancer, incidental gallbladder cancer can be associated with a varied prognosis. Imaging with computed tomography (CT), magnetic resonance imaging (MRI), and [18]F-fluorodeoxyglucose (FDG) positron emission tomography (PET), as well as diagnostic laparoscopy, all have varying roles in the workup of patients with incidental gallbladder cancer. For patients with T1b, T2, and ...

Drug combination boosts cancer survival

Pharmacy Europe — Tue, 02 Jun 2009 22:35:17 +0100

A combination of two chemotherapy drugs can significantly improve the survival rate of patients with advanced gallbladder and bile duct cancer (Source: Pharmacy Europe)

EUS-guided Biliary Drainage with One-step Placement of Newly Designed Fully Covered Metal Stent for Malignant Biliary Obstruction: A Prospective Feasibility Study

The Digital Atlas of Video Education - Gastroenterology — Mon, 01 Jun 2009 06:06:49 +0100

In conclusion, EUD with one-step placement of fully covered metal stent may be feasible, safe, and effective for an alternative to percutaneous transhepatic biliary drainage (PTBD) in case of malignant biliary obstruction when ERCP is unsuccessful. (Source: The Digital Atlas of Video Education - Gastroenterology)

Ruptured gallbladder as the first presentation of breast cancer

World Journal of Surgical Oncology — Mon, 01 Jun 2009 04:00:00 +0100

Conclusion: We present a rare case of gall bladder perforation from metastatic breast cancer. (Source: World Journal of Surgical Oncology)

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Foreword

Obstetrics and Gynecology Clinics — Mon, 01 Jun 2009 04:00:00 +0100

This issue of the Obstetrics and Gynecology Clinics of North America, with Dr. Raul Artal as Guest Editor, provides a timely update on the assessment and management of obese women. Obesity is the fastest growing health problem in the United States, especially among minority women, and approximately one third of all US women are obese. This issue describes how obesity is associated with increased healthcare costs and such morbid conditions as type 2 diabetes, infertility, gallbladder disease, and several cancers, including breast, colon, and uterine malignancies. Endometrial cancer, the most common gynecologic malignancy, is nearly five times more common in obese than in nonobese women. Obesity and being overweight are also associated with hypertension and an increased risk for heart diseas...

Correlation between cholelithiasis and gallbladder carcinoma in surgical and autopsy specimens.

Collegium Antropologicum — Sun, 31 May 2009 23:00:00 +0100

Authors: Mlinarić-Vrbica S, Vrbica Z Gallbladder (GB) cancer is the most common malignant lesion of the biliary tract. The decision for a cholecystectomy in asymptomatic cholelithiasis as a measure of the secondary prevention of gallbladder cancer is based on the data of incidence and selected predictive factors for a specific population. A consecutive series of 3351 cholecystectomies in five year period was reviewed. That data was compared with the data from 2395 consecutive autopsies from the same period. Possible risk factors for gallbladder cancer were analysed. In surgical specimens, the incidence of gallbladder carcinoma was 0.62%. Of those, 24% were in patients younger than 60 years and 95.24% were associated with cholelithiasis. In autopsy material, in cases in which chol...

Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agent d-19575 (glufosfamide) in patients with solid tumors

Cancer Chemotherapy and Pharmacology — Fri, 29 May 2009 08:15:44 +0100

Conclusions Our results show that d-19575 can be safely administered by infusion over 6 h at 4,500 mg/m2 every 3 weeks. The safety profile and potential antitumor activity of d-19575 show that phase II studies of this drug are warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1028-3Authors Toshio Shimizu, Kinki University School of Medicine Department of Medical Oncology 377-2 Ohno-higashi Osaka-Sayama Osaka 589-8511 JapanIsamu Okamoto, Kinki University School of Medicine Department of Medical Oncology 377-2 Ohno-higashi Osaka-Sayama Osaka 589-8511 JapanKenji Tamura, National Cancer Center Hospital Outpatient Treatment Center 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanTaroh Satoh, Kinki University School of Medicine De...

Prostate cancer is associated with the metabolic syndrome

Journal of Men's Health — Sun, 24 May 2009 07:33:47 +0100

Conclusions: We conclude that the prevalence of the MS is high in subjects with prostate cancer. (Source: Journal of Men's Health)

Study Examines Trends In Gallbladder Cancer Over Four Decades

Health News from Medical News Today — Thu, 21 May 2009 10:00:00 +0100

Overall prognosis for gallbladder cancer appears to be improving, although many patients still have incurable disease and poor survival rates, according to a report in the May issue ofArchives of Surgery, one of the JAMA/Archives journals. (Source: Health News from Medical News Today)

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Prognosis for Gallbladder Cancer Improving But Survival Rates Remain Poor

Medscape Medical News Headlines — Wed, 20 May 2009 15:58:02 +0100

Although many patients diagnosed with gallbladder cancer present with advanced-stage disease and have very poor survival, the overall prognosis is improving, according to an analysis that examined trends over the past 4 decades. Medscape Medical News (Source: Medscape Medical News Headlines)

Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population

Journal of Gastroenterology — Wed, 20 May 2009 06:25:54 +0100

Discussion An association of PTGS2 −1195G>A polymorphism with gallbladder cancer, particularly in patients without gallstones, suggests a direct role of PTGS2 in cancer development. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-009-0071-5Authors Kshitij Srivastava, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Genetics Lucknow 226014 Uttar Pradesh IndiaAnvesha Srivastava, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Genetics Lucknow 226014 Uttar Pradesh IndiaSachchida Nand Pandey, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Department of Genetics Lucknow 226014 Uttar Pradesh IndiaAshok Kumar, SGPGIMS Departm...

Prognosis Remains Poor in Gallbladder Cancer

Modern Medicine — Wed, 20 May 2009 04:00:00 +0100

Median survival time for patients with gallbladder cancer has increased for more than four decades, but many patients still present with advanced disease and prognosis remains poor, according to a paper in the May Archives of Surgery. (Source: Modern Medicine)

Study Cites Gains in Gall Bladder Cancer Treatment

MedlinePlus Health News — Mon, 18 May 2009 20:00:00 +0100

Early detection, aggressive surgery boosts survival times, researchers say. Source: HealthDay (Source: MedlinePlus Health News)

Study examines trends in gallbladder cancer over 4 decades

EurekAlert! - Cancer — Mon, 18 May 2009 04:00:00 +0100

(JAMA and Archives Journals) Overall prognosis for gallbladder cancer appears to be improving, although many patients still have incurable disease and poor survival rates, according to a report in the May issue of Archives of Surgery, one of the JAMA/Archives journals. (Source: EurekAlert! - Cancer)

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Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations

Journal of Experimental and Clinical Cancer Research — Mon, 18 May 2009 04:00:00 +0100

In this study, we examined phospho-ERK1/2 (p-ERK1/2) and PI3K expression and analyzed its clinicopathological impact in gallbladder adenocarcinoma. Methods: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens. Results: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis. The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P (Source: Journ...

PAPER: Trends in Presentation and Survival for Gallbladder Cancer During a Period of More Than 4 Decades: A Single-Institution Experience

Archives of Surgery — Mon, 18 May 2009 04:00:00 +0100

Conclusions Gallbladder cancer is incidentally found during 0.25% of laparoscopic cholecystectomies. As T stage increases, the likelihood of residual disease on reexploration increases. Although many patients with gallbladder cancer present with incurable disease and have very poor survival, the overall prognosis is improving, likely because of more extensive operations. (Source: Archives of Surgery)

INVITED CRITIQUE: Trends in Presentation and Survival for Gallbladder Cancer During a Period of More Than 4 Decades--Invited Critique

Archives of Surgery — Mon, 18 May 2009 04:00:00 +0100

(Source: Archives of Surgery)

The CHOLEGAS Study: Multicentric randomized, blinded, controlled trial of Gastrectomy plus Prophylactic Cholecystectomy versus Gastrectomy only, in adults submitted to Gastric cancer surgery with curative intent.

Trials — Fri, 15 May 2009 04:00:00 +0100

Background: The incidence of gallstones and gallbladder sludge is known to be higher in patients after gastrectomy than in general population. This higher incidence is probably related to surgical dissection of the vagus nerve branches and the anatomical gastrointestinal reconstruction. Therefore, some surgeons perform routine concomitant cholecystectomy during standard surgery for gastric malignancies. However, not all the patients who are diagnosed to have cholelithiasis after gastric cancer surgery will develop symptoms or require additional surgical treatments and a standard laparoscopic cholecystectomy is feasible even in those patients who underwent previous gastric surgery. At the present, no randomized study has been published and the decision of gallbladder management is left to e...

Coordinate Loss of Fragile Gene Expression in Pancreatobiliary Cancers: Correlations Among Markers and Clinical Features

Annals of Surgical Oncology — Tue, 12 May 2009 05:59:38 +0100

Conclusion Loss of Fhit and Wwox expression does not predict tumor progression or patient survival, suggesting that loss of expression of genes at the exquisitely replication stress sensitive chromosome fragile regions is an early event in the pathogenesis of cancers of the gallbladder, pancreas, and ampulla. Content Type Journal ArticleCategory Translational Research and BiomarkersDOI 10.1245/s10434-009-0507-4Authors Mark Bloomston, The Ohio State University Department of Surgery Columbus OH USAJeffrey Kneile, The Ohio State University Department of Pathology Columbus OH USAMatthew Butterfield, The Ohio State University Department of Surgery Columbus OH USAMary Dillhoff, The Ohio State University Department of Surgery Columbus OH USAPeter Muscarella, The Ohio State U...

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Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract

Journal of Experimental and Clinical Cancer Research — Tue, 12 May 2009 04:00:00 +0100

Conclusions: This study defined regions of the genome associated with changes in DNA copy number and gene expression in specific subtypes of biliary cancers. The findings have implications for identification of therapeutic targets, screening, and prognostication. (Source: Journal of Experimental and Clinical Cancer Research)

New insights into the role of the tuberous sclerosis genes in leukemia

Leukemia Research — Thu, 07 May 2009 15:34:46 +0100

Abstract: The genes TSC1 and TSC2, encoding hamartin and tuberin, respectively, have been shown to be involved in the development of the autosomal dominantly inherited tumor syndrome tuberous sclerosis (TSC). However, inactivation of these genes has also been demonstrated to be associated with sporadic bladder cancer, ovarian and gall bladder carcinoma, non-small-cell carcinoma of the lung, breast cancer, pancreatic cancer, astrocytoma, xanthoastrocytoma, ependymomas, oral squamous cell carcinoma and endometrial cancer. The hamartin/tuberin protein complex plays a central role in the regulation of the mammalian target of rapamycin (mTOR) signalling network. A wide variety of components of the mTOR cascade have been demonstrated to be involved in many different human cancers. Mutations in s...

Statins may protect against liver cancer

Health News - UPI.com — Wed, 06 May 2009 19:43:59 +0100

HOUSTON, May 6 (UPI) -- Statins, which lower cholesterol, may have a protective effect in the prevention of liver cancer and may reduce gallbladder removal risk, U.S. researchers say. (Source: Health News - UPI.com)

Cancer Preventive Effect For Statins Indicated By Study

Health News from Medical News Today — Wed, 06 May 2009 12:00:00 +0100

The commonly used prescription statin drugs may have a protective effect in the prevention of liver cancer and lead to a reduction in the need for gallbladder removals, according to two studies published in Gastroenterology. (Source: Health News from Medical News Today)

Study indicates cancer preventive effect for statins

EurekAlert! - Medicine and Health — Tue, 05 May 2009 04:00:00 +0100

(American Gastroenterological Association) The commonly used prescription statin drugs may have a protective effect in the prevention of liver cancer and lead to a reduction in the need for gallbladder removals. As millions of Americans use statins each day to help lower their cholesterol and risk of heart disease, researchers are learning of the beneficial effects these drugs may have on gastrointestinal disorders. (Source: EurekAlert! - Medicine and Health)

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A phase II study of uracil-tegafur plus doxorubicin and prognostic factors in patients with unresectable biliary tract cancer

Cancer Chemotherapy and Pharmacology — Thu, 30 Apr 2009 06:02:50 +0100

Conclusions Combination chemotherapy of UFT and doxorubicin had minimum activity against advanced biliary tract cancer. Performance status was identified as the most important prognostic factor in patients who received systemic chemotherapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1011-zAuthors Junji Furuse, National Cancer Center Hospital East Division of Hepatobiliary and Pancreatic Oncology Kashiwa JapanTakuji Okusaka, National Cancer Center Hospital Hepatobiliary and Pancreatic Oncology Division Tokyo JapanShinichi Ohkawa, Kanagawa Cancer Center Division of Hepatobiliary and Pancreatic Medical Oncology Yokohama JapanMichitaka Nagase, Tochigi Cancer Center Department of Imaging Diagnosis Utsunomiya JapanAkihiro Funakoshi, National...

Phase II and pharmacokinetic trial of rebeccamycin analog in advanced biliary cancers

Cancer Chemotherapy and Pharmacology — Tue, 28 Apr 2009 16:44:27 +0100

Conclusion Although RA has a response rate of 5% in advanced biliary cancers, it is associated with significant numbers of patients experiencing prolonged stable disease. Biliary concentrations of RA are significantly greater than plasma concentrations. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1005-xAuthors Afshin Dowlati, University Hospitals Case Medical Center 11100 Euclid Avenue Cleveland OH 44106 USAJames Posey, University of Alabama Birmingham AL USARamesh K. Ramanathan, University of Pittsburgh Medical Center and Cancer Institute Division of Hematology/Oncology, Department of Medicine Pittsburgh PA USALinda Rath, University Hospitals Case Medical Center 11100 Euclid Avenue Cleveland OH 44106 USAPingfu Fu, University Hospitals C...

Portal vein branching pattern in anomalous right-sided round ligament

Abdominal Imaging — Sat, 25 Apr 2009 07:10:26 +0100

Conclusions Trifurcate pattern of portal vein branching in all four cases. Right-sided round ligament was attached to the bifurcation of the right anterior portal vein in all the cases. The left portal vein branched into posterior and paramedian branches. Content Type Journal ArticleDOI 10.1007/s00261-009-9520-0Authors Rajesh Gupta, Postgraduate Institute of Medical Education and Research Surgical Gastroenterology Division, Department of General Surgery Sector 12 Chandigarh 160012 IndiaAkinari Miyazaki, Chiba Cancer Center Department of Gastroenterological Surgery 662-2, Nitona, Chuoh-ku Chiba 260-8717 JapanAkihiro Cho, Chiba Cancer Center Department of Gastroenterological Surgery 662-2, Nitona, Chuoh-ku Chiba 260-8717 JapanMunemasa Ryu, Chiba Cancer Center Department ...

Biliary - Type III Choledochal Cyst with Biliary Reflux through the Minor Papilla; Needle Knife Major Papillotomy

The Digital Atlas of Video Education - Gastroenterology — Thu, 23 Apr 2009 10:04:08 +0100

This 17 year old male was referred for unexplained acute pancreatitis. His initial episode of acute pancreatitis resulted in a 5 day hospitalization, with serum lipase 10 times normal, and CT showing mild interstitial pancreatitis. He has had intermittent mild abdominal pain since. Laparoscopic cholecystectomy was performed because of a dilated gallbladder; intraoperative cholangiogram showed dilation of the terminal bile duct. ERCP attempted locally resulted in inability to find any orifice or cannulate any duct in the major papilla. He was referred to us for further evaluation. MRCP with secretin was performed. With successive images after secretin injection, you can see cystic dilation of terminal bile duct and pancreatic duct, which appear to be separate and parallel, then fuse into o...