MedWorm: Gastric (Stomach) Cancer

Six-Organ Transplant Girl Goes Home Today

Health News from Medical News Today — Fri, 03 Feb 2012 18:00:00 +0100

After 100 days in hospital and undergoing a complicated 6-organ transplant, 9-year-old Alannah Shevenell, from Maine, leaves Boston Children's Hospital today and goes home. Alannah has been treated for a rare form of cancer; an inflammatory myofibroblastic tumor continued to grow after all possible treatments failed, and was compromising her internal organs. A team of surgeons, led by Dr. Heung Bae Kim, the hospital's Pediatric Transplant Center director, performed the transplant procedure of Alannah's liver, spleen, pancreas, stomach, small intestine and esophagus... (Source: Health News from Medical News Today)

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A Phase II Study of Capecitabine plus Oxaliplatin as First-Line Chemotherapy in Elderly Patients with Advanced Gastric Cancer

Chemotherapy — Thu, 02 Feb 2012 12:48:14 +0100

Chemotherapy 2012;58:1–7 (DOI:10.1159/000335585) (Source: Chemotherapy)

Crab-like robot sent down throat removes stomach cancer with delicate pincers

the Mail online | Health — Thu, 02 Feb 2012 09:35:00 +0100

Researchers from Singapore's National University Hospital have created a crab-like miniature robot with a pincer and a hook that can remove early-stage stomach cancers without leaving any scars. (Source: the Mail online | Health)

Effect of Roux‐en‐Y gastric bypass on testosterone and prostate‐specific antigen

British Journal of Surgery — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion:RYGB normalizes the serum testosterone level. PSA levels increase with weight loss and may be inversely correlated with changes in plasma volume, indicating that PSA levels may be artificially low in obese men owing to haemodilution. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

Children’s becomes first hospital in New England to complete six organ transplant

Thrive, Children's Hospital Boston — Wed, 01 Feb 2012 15:57:55 +0100

The cover of today’s Boston Globe features the beaming face of Alannah Shevenell, a 9 year-old who will be heading home to Maine this morning after a three-month stay at Children’s Hospital Boston. For just under 100 days Alannah and her grandmother have been staying at Children’s while she received treatment for a rare and aggressive cancer that was compromising several of her internal organs. When all other treatments had failed, Heung Bae Kim, MD, director of Children’s Pediatric Transplant Center (PTC), suggested a multivisceral transplant that would remove Alannah’s tumor and replace the six organs that had been damaged by its presence. Under Kim’s guidance surgeons from Children’s PTC performed the 14-hour procedure. Once Alannah’s tumo...

9-Year-Old Girl Heading Home After 6 Organ Transplant At Children’s Hospital

Wed, 01 Feb 2012 13:14:26 +0100

BOSTON (AP) — A 9-year-old Maine girl is heading home after a groundbreaking multiple organ transplant at Children’s Hospital Boston. Alannah Shevenell of Hollis underwent 14 hours of surgery in October to remove an aggressive tumor and to undergo a transplant of her stomach, pancreas, spleen, liver, small bowel and esophagus. Hospital officials say it was the first known esophageal transplant in the world and the largest number of organs transplanted into a person at one time in New England. Alannah was diagnosed with a rare former of cancer when she was 4. The tumor snaked and twisted itself around her internal organs, choking the life out of them. It didn’t respond to chemotherapy or surgery to get rid of it. Even the transplant was risky. Alannah is scheduled to come Wedn...

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Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

BMC Cancer — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: Our data showed that PIK3CA mutations were not common, but its amplification was very common in gastric cancer and may be a major mechanism in activating the PI3K/Akt pathway in gastric cancer. Importantly, Kaplan-Meier survival curves revealed that PIK3CA amplification was significantly positively associated with poor survival of gastric cancer patients. Collectively, the PI3K/Akt signaling pathway may be an effective therapeutic target in gastric cancer. (Source: BMC Cancer)

Inhibition of NF‐ κB Activity by Minor Polar Components of Extra‐Virgin Olive Oil at Gastric Level

Phytotherapy Research — Wed, 01 Feb 2012 05:00:00 +0100

The present work evaluates the effect of olive oil phenols on NF‐κB activity in human gastric adenocarcinoma cells. The total phenol content was measured by the Folin Ciocalteu method, whereas the composition was assessed by LC‐MS/MS analysis. Secoiridoids represented 71% and 83% of the Italian and Spanish extracts, respectively, phenol alcohols were in the range 9–13%. Ligustroside aglycone was the most abundant (37% and 46%, respectively, in the Italian and Spanish sample), and the concentration of flavonoids AP and LU was below 1%. Phenol extracts were assayed at 0.25–7.5 µg/mL, whereas single compounds were at 0.5–25 µ m. Both the extracts inhibited the NF‐κB driven transcription in a concentration‐dependent manner: IC50 for the Italian and the Spanish extract wer...

Association of hOGG1 Ser326Cys polymorphism with gastric cancer risk: a meta-analysis.

Molecular Biology Reports — Wed, 01 Feb 2012 05:00:00 +0100

In conclusion, we did not found the evidence that the Cys allele at codon 326 of hOGG1 could increase GC risk in our analysis. PMID: 22294108 [PubMed - as supplied by publisher] (Source: Molecular Biology Reports)

Experts build crab-like robot to remove stomach cancer

Reuters: Health — Wed, 01 Feb 2012 03:49:24 +0100

SINGAPORE (Reuters) - Inspired by Singapore's famous chilli crab dish, researchers have created a miniature robot with a pincer and a hook that can remove early-stage stomach cancers without leaving any scars. (Source: Reuters: Health)

Green Tea & Stomach Cancer

About.com Eating Disorders — Tue, 31 Jan 2012 05:00:00 +0100

A recent study published in the New England Journal of Medicine found that green tea consumption was not associated with a decreased risk of gastric cancer. But what were the study's flaws? (Source: About.com Eating Disorders)

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The association of statins and taxanes: an efficient combination trigger of cancer cell apoptosis

British Journal of Cancer AOP — Tue, 31 Jan 2012 05:00:00 +0100

Authors: J Follet, L Corcos, G Baffet, F Ezan, F Morel, B Simon & C Le Jossic-Corcos (Source: British Journal of Cancer AOP)

Serological Assessment of gastric mucosal Atrophy in gastric Cancer.

BMC Gastroenterology — Tue, 31 Jan 2012 05:00:00 +0100

Background: Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1(PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. Methods: Histological and serological samples of 118 patients with gastric cancer have been assessed for tumor specific characteristics (Lauren type, localisation), degree of mucosal abnormalities (intestinal metaplasia, atrophy) and serological parameters (PG1, PG2, PG1/2-ratio, G17, H. pylori IgG, CagA status). Association of the general factors to the different serological values have been statistically analyzed. Resu...

Ten cases of gastro‐tracheobronchial fistula: a serious complication after esophagectomy and reconstruction using posterior mediastinal gastric tube

Diseases of the Esophagus — Tue, 31 Jan 2012 05:00:00 +0100

SUMMARYGastro‐tracheobronchial fistula (GTF) is a rare but life‐threatening complication specifically observed after esophagectomy and reconstruction using posterior mediastinal gastric tube. Ten cases of GTF were encountered in three hospitals in 2000–2009. Their clinicopathological, surgical, and postoperative care are summarized, together with a review of previously reported cases. GTF was classified as anastomotic leakage (n= 5), gastric necrosis (n= 4), and gastric ulcer type (n= 1). The anastomotic leakage type appeared about 2 weeks (postoperative day [POD]: 8–35) after esophagectomy, was located in the cervical or higher thoracic trachea. Breathing and pneumonia were controlled by tracheal tube placed in the distal of fistula. The gastric necrosis type was noted in patients...

Breast cancer biomarkers predict weight loss after gastric bypass surgery

BMC Research Notes — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions: Adiponectin increases locally in the breast and systemically in premenopausal women after gastric bypass. s-adiponectin in pre- and nPSA in postmenopausal women correlated with greater weight loss. This study provides preliminary evidence for biologic markers to predict weight loss after gastric bypass surgery. (Source: BMC Research Notes)

Bowel cancer awareness campaign launched

OnMedica Latest News — Mon, 30 Jan 2012 05:00:00 +0100

First ever national bowel cancer campaign aims to boost early diagnosisRelated items from OnMedicaFaecal blood testing best to spot cancer and cost-effectiveNational campaign to raise patient awareness of bowel cancerBenefits of aspirin to treat bowel cancerSmoking may worsen cancer painAudit of oesophago-gastric cancer calls for better staffing (Source: OnMedica Latest News)

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GATA5 CpG island methylation in renal cell cancer: a potential biomarker for metastasis and disease progression

BJU International — Mon, 30 Jan 2012 05:00:00 +0100

CONCLUSIONS• The association of GATA5 hypermethylation with metastasis and progression‐free survival of patients indicates that epigenetic alterations of GATA5 participate in renal cell carcinogenesis.• Moreover, GATA5 CGI methylation could serve as a biomarker for tumour progression, although prospective and functional investigations are necessary to clarify whether independent information for future clinical management of patients with RCC can be obtained. (Source: BJU International)

Superoxide dismutase activity of Helicobacter pylori per se from 158 clinical isolates and the characteristics

Microbiology and Immunology — Mon, 30 Jan 2012 05:00:00 +0100

ABSTRACTOur aims are to investigate the correlation between superoxide dismutase (SOD) activity of Helicobacter pylori (H. pylori) and gastroduodenal diseases and the characteristics of strains exposed to oxidative stress. Two sequenced strains, 26695 and J99, and clinical isolates from 156 Japanese patients with gastroduodenal diseases such as gastric cancer (n = 59) and non‐cancer (n = 97) were utilized. SOD activities of all 158 isolates were measured by a SOD Assay Kit‐WST and were divided into 3 groups; high‐SOD activity (>0.22, n = 2), moderate‐SOD activity (0.15≦　≦0.22, n = 16) and low‐SOD activity (<0.15, n = 140) groups. The expressions of H. pylori iron‐cofactored SOD (Fe‐SOD) were examined by western blotting with anti‐H. pylori Fe‐SOD antibody prep...

Phase II Trial of Preoperative Chemotherapy with Docetaxel, Cisplatin and S-1 for T4 Locally Advanced Gastric Cancer

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

The standard treatment for T4 locally advanced gastric cancer is gastrectomy with D2 lymph node dissection followed by adjuvant chemotherapy with S-1 for 12 months; however, prognostic outcome in Stage IIIb has been insufficient. It is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and S-1 (divided DCS therapy). A multicenter Phase II study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemotherapy followed by gastrectomy. Fifty-five patients are required for this study. The primary endpoint of the study is pathological response rate of primary lesions. Secondary endpoints are overall survival, disease-free survival, R0 resection rate and adverse events. (Source: Japanese Journal of Clinica...

Cancer Incidence and Incidence Rates in Japan in 2006: Based on Data from 15 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

The Japan Cancer Surveillance Research Group estimated the cancer incidence in 2006 as part of the Monitoring of Cancer Incidence in Japan (MCIJ) project, on the basis of data collected from 15 of 32 population-based cancer registries. The total number of incidences in Japan for 2006 was estimated as 664 398 (C00–C96). The leading cancer site was stomach for men and breast for women. Age-standardized incidence rates remained at almost the same level as for the previous 3 years. (Source: Japanese Journal of Clinical Oncology)

Analysis for the Combination Expression of CK20, FABP1 and MUC2 is Sensitive for the Prediction of Peritoneal Recurrence in Gastric Cancer

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

In this study, expressions of five specific marker genes, namely, TFF1, TFF2, CK20, FABP1 and MUC2, were evaluated for their usefulness as markers of micro-dissemination. It was found that reverse transcriptase-polymerase chain reaction for these five genes yielded results highly specific for the depth of invasion and disease stage. Furthermore, the expression of CK20, FABP1 and MUC2 was a reliable prognostic indicator of peritoneal metastasis. Our results suggest that evaluation of the expression of CK20, FABP1 and MUC2 in peritoneal washings is a useful tool for identifying patients at high risk of peritoneal recurrence who may need adjuvant chemotherapy. (Source: Japanese Journal of Clinical Oncology)

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Trends in Stomach Cancer Mortality Rates in Japan, USA, UK, France and Korea Based on the WHO Mortality Database

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

(Source: Japanese Journal of Clinical Oncology)

Experts recommend genetic counseling for young sarcoma patients

Thrive, Children's Hospital Boston — Sun, 29 Jan 2012 13:41:39 +0100

Genetic testing may help sarcoma patients and their famlies know their risk of other cancers later in life If your child is diagnosed with a sarcoma—a tumor in connective tissue like muscles or bones—it’s natural to become totally focused on his immediate recovery. But what if beating sarcoma wasn’t the only time your child might face cancer? Data shows that there is a link between sarcomas and Li-Fraumeni syndrome, a rare condition that raises a person’s risk of developing one or more cancers to as high as 85 percent. Cancers typically diagnosed in patients with Li-Fraumeni syndrome include breast cancer, sarcomas, brain tumors, acute leukemia and adrenal cortical carcinoma. Recently, the list has been expanded to include colon cancer and stomach cancer. Li-Fraumeni syndrome m...

APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:16 +0100

Conclusion Sporadic GCs exhibit different mechanisms of APC regulation. Content Type Journal ArticleCategory Research ArticlesPages 60-65DOI 10.1007/s12094-012-0762-xAuthors Zhengyu Fang, Biomedical Research Institute Shenzhen-PKU-HKUST Medical Center Guangdong Province, Shenzhen, People’s Republic of ChinaYi Xiong, Biomedical Research Institute Shenzhen-PKU-HKUST Medical Center Guangdong Province, Shenzhen, People’s Republic of ChinaJiana Li, Biomedical Research Institute Shenzhen-PKU-HKUST Medical Center Guangdong Province, Shenzhen, People’s Republic of ChinaLi Liu, Biomedical Research Institute Shenzhen-PKU-HKUST Medical Center Guangdong Province, Shenzhen, People’s Republic of ChinaWei Zhang, JNU-HKUST Joint Lab Ji-Nan University, Guangdong, People’s Repu...

Proteomic research progress in lymphatic metastases of cancers

Clinical and Translational Oncology — Sat, 28 Jan 2012 16:53:11 +0100

Abstract Lymph node metastasis (LNM) is recognised as an important factor involved in malignant tumour progression by interfering with a favourable prognosis. It is involved in a variety of cancers. Proteins are believed to play important roles in the LNM of cancers. The rapid achievements of state-of-the-art proteomic techniques have emerged as the key technologies successfully applied to identify markers for cancers at high-throughput level by providing novel targets and creating possible therapeutic interventions in cancer research. This review summarises recent progress in proteomic research in hepatocarcinoma, gastric cancer, oesophageal cancer, colorectal cancer, breast cancer, lung cancer and nasopharyngeal cancer. Actin, heat-shock proteins (HSPs), annexins, cytoke...

[Comment] Adjuvant therapy for gastric cancer after D2 gastrectomy

LANCET — Sat, 28 Jan 2012 05:00:00 +0100

Although adjuvant therapy for gastric cancer is known to improve prognosis, controversies remain about the choice of chemotherapeutic regimens, the use of radiation therapy, and the selection of patients who are likely to benefit from different therapies. Adjuvant therapy is used to eradicate potential micrometastases after curative surgery and, therefore, therapeutic strategies vary dependent on anticipated locoregional disease control after surgery, and by institution and country. It seems reasonable to apply adjuvant chemoradiotherapy, providing a combination of radiation therapy for local control and chemotherapy to achieve systemic control and radiosensitisation, to patients with less locoregional control; and systemic adjuvant chemotherapy to those with greater local control after su...

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[Articles] Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial

LANCET — Sat, 28 Jan 2012 05:00:00 +0100

Adjuvant capecitabine plus oxaliplatin treatment after curative D2 gastrectomy should be considered as a treatment option for patients with operable gastric cancer. (Source: LANCET)

Cytokeratin Expression Profiling in Gastric Carcinoma: Clinicopathologic Significance and Comparison with Tumor-Associated Molecules

Pathobiology — Fri, 27 Jan 2012 23:00:00 +0100

Pathobiology 2012;79:154–161 (DOI:10.1159/000335694) (Source: Pathobiology)

Low-Dose Docetaxel Combined with (−)-Epigallocatechin-3-Gallate Inhibits Angiogenesis and Tumor Growth in Nude Mice with Gastric Cancer Xenografts

Cancer Biotherapy and Radiopharmaceuticals — Fri, 27 Jan 2012 16:55:19 +0100

Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. (Source: Cancer Biotherapy and Radiopharmaceuticals)

Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates

Glycobiology — Fri, 27 Jan 2012 05:00:00 +0100

Mucin-type glycosylation [α-N-acetyl-d-galactosamine (α-GalNAc)-O-Ser/Thr] on proteins is initiated biosynthetically by 16 homologous isoforms of GalNAc-Ts (uridine diphosphate-GalNAc:polypeptide N-acetylgalactosaminyltransferases). All the GalNAc-Ts consist of a catalytic domain and a lectin domain. Previous reports of GalNAc-T assays toward peptides and α-GalNAc glycopeptides showed that the lectin domain recognized the sugar on the substrates and affected the reaction; however, the details are not clear. Here, we report a new strategy to give insight on the sugar recognition ability and the function of the GalNAc-T3 lectin domain using chemically synthesized natural-type (α-GalNAc-O-Thr) and unnatural-type [β-GalNAc-O-Thr, α-Fuc-O-Thr and β-GlcNAc...

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

Journal of Translational Medicine — Fri, 27 Jan 2012 05:00:00 +0100

Background: Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown. Methods: 197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the prognostic effects of vitamin D. Results: The mean vitamin D levels of the 197 gastric patients was 49.85 +/- 23.68nmol/L, among whom 114(57.9%) were deficient in Vitamin D(75nmol/L). Clinical stage (P = 0.004) an...

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To resect or not resect in metastatic gastric cancer: that is the question!

Gastric Cancer — Thu, 26 Jan 2012 16:46:18 +0100

Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s10120-011-0136-zAuthors Florian Lordick, 3rd Department of Medicine (Hematology and Oncology), Clinic Braunschweig, Celler Str. 38, 38114 Braunschweig, Germany Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 (Source: Gastric Cancer)

ABC screening for gastric cancer is not applicable in a Japanese population with high prevalence of atrophic gastritis

Gastric Cancer — Thu, 26 Jan 2012 16:46:18 +0100

Abstract A combination of the detection of serum anti-Helicobacter pylori antibody and measurement of the level of serum pepsinogens (PG)s, known as the ABC method, has been used in screening for gastric cancer. The ABC method has been shown to be useful in urban and/or younger populations. The aim of this study was to assess whether this method is applicable for an agricultural population with a high incidence of gastric cancer. In all, 1048 healthy adults (401 men and 647 women) who participated in a mass survey in April 2005 were examined. Their serum samples were tested to determine the prevalence of anti-H. pylori antibody, and the levels of PG I and PG II were also measured to assess the presence of atrophic gastritis. Of the elderly subjects born before 1940, 59.4% w...

Irregular bowel movement in gastrectomized subjects: bowel habits, stool characteristics, fecal flora, and metabolites

Gastric Cancer — Thu, 26 Jan 2012 16:46:18 +0100

Conclusions Many gastrectomized patients with irregular bowel movements exhibited significant changes showing impaired intestinal microflora and metabolite levels. Content Type Journal ArticleCategory Original articlePages 1-9DOI 10.1007/s10120-011-0129-yAuthors Teruaki Aoki, The Jikei University School of Medicine, #303/6-13-7 Honkomagome, Bunkyo-Ku, Tokyo, 113-0021 JapanIchiro Yamaji, Post-gastrectomy Patients’ Association “ALPHA CLUB”, Tokyo, JapanTsuyoshi Hisamoto, Post-gastrectomy Patients’ Association “ALPHA CLUB”, Tokyo, JapanMasanori Sato, Post-gastrectomy Patients’ Association “ALPHA CLUB”, Tokyo, JapanTomoko Matsuda, Post-gastrectomy Patients’ Association “ALPHA CLUB”, Tokyo, Japan Journal Gastric CancerOnline ISSN 1436-3305Pr...

WITHDRAWN: Extended versus limited lymph nodes dissection technique for adenocarcinoma of the stomach.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: D2 dissection carries increased mortality risks associated with spleen and pancreas resection, and probably with inexperience and low case volumes. Randomised studies show no evidence of overall survival benefit, but possible benefit in T3+ tumours. These results may be confounded by surgical learning curves and poor surgeon compliance. Non-randomised comparisons suggest a possible survival benefit for D2 in intermediate UICC stages. Observational studies show high 5 year survival and low operative mortality after D2 dissection in experienced units, and poor results after D1 dissection in non-specialist units. Further studies, with precautions to eliminate learning curve effects, contamination and non-compliance, are needed to evaluate D2 dissection in intermediate stage gastr...

Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery

Surgery Today — Thu, 26 Jan 2012 06:44:05 +0100

Conclusions The 2-year administration of oral anti-cancer drugs as postoperative adjuvant chemotherapy might improve the outcome of stage II, III gastric cancer patients. Randomized control trials are warranted to prove the effectiveness of this 2-year regimen. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00595-012-0129-5Authors Toshiro Okuyama, Department of Surgery, Fukuoka City Hospital, 13-1 Yoshizuka-honmachi, Hakata-ku, Fukuoka, 812-0046 JapanDaisuke Korenaga, Department of Surgery, Fukuoka City Hospital, 13-1 Yoshizuka-honmachi, Hakata-ku, Fukuoka, 812-0046 JapanAi Edagawa, Department of Surgery, Fukuoka City Hospital, 13-1 Yoshizuka-honmachi, Hakata-ku, Fukuoka, 812-0046 JapanShinji Itoh, Department of Surgery, Fukuoka City Hospi...

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Adenocarcinoma in the jejunal pouch after proximal gastrectomy for early stage upper gastric cancer: report of a case

Surgery Today — Thu, 26 Jan 2012 06:44:04 +0100

Abstract An 84-year-old male was admitted to a local clinic suffering from general fatigue with associated anemia, and therefore was referred to our hospital. His medical history included a proximal gastrectomy with the formation of a jejunal pouch as a reconstructive treatment for early upper gastric cancer at 78 years of age (6 years prior). A type 2 tumor located in the jejunal pouch almost completely surrounded by small intestinal mucosa was demonstrated by gastrointestinal endoscopy. The biopsy specimens showed a moderately differentiated tubular adenocarcinoma. Computed tomography showed no lymphadenopathy or hepatic metastases. A resection of the residual stomach and jejunal pouch was performed. Based on the histological findings from the resected specimen,...

The relationship between tissue factor and cancer progression: insights from bench and bedside

Blood — Thu, 26 Jan 2012 05:00:00 +0100

It is now widely recognized that a strong correlation exists between cancer and aberrant hemostasis. Patients with various types of cancers, including pancreatic, colorectal, and gastric cancer, often develop thrombosis, a phenomenon commonly referred to as Trousseau syndrome. Reciprocally, components from the coagulation cascade also influence cancer progression. The primary initiator of coagulation, the transmembrane receptor tissue factor (TF), has gained considerable attention as a determinant of tumor progression. On complex formation with its ligand, coagulation factor VIIa, TF influences protease-activated receptor-dependent tumor cell behavior, and regulates integrin function, which facilitate tumor angiogenesis both in vitro and in mouse models. Furthermore, evidence exists that a...

A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer

Gastric Cancer — Wed, 25 Jan 2012 18:12:35 +0100

Conclusion Our study did not show sufficient prolongation of survival with the concurrent strategy to proceed to a phase-III trial; however, the sequential arms showed survival comparable to that in the concurrent arms, with less toxicity. In patients who are ineligible for cisplatin (CDDP), sequential treatment starting with S-1 and proceeding to PTX would be a good alternative strategy, considering quality of life (QOL) and the cost-benefits of an oral agent as first-line treatment. Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s10120-011-0124-3Authors Kazuhiro Nishikawa, Department of Surgery, Osaka General Medical Center, 3-1-56 Bandai-higashi, Sumiyoshi-ku, Osaka, 558-8558 JapanSatoshi Morita, Department of Biostatistics and Epidemi...

Biomarkers for antitumor activity of bevacizumab in gastric cancer models

BMC Cancer — Wed, 25 Jan 2012 05:00:00 +0100

Conclusions: VEGF levels and VEGF/bFGF ratios in tumors were related to bevacizumab sensitivity of the xenografts tested. Further clinical investigation into useful predictive markers for bevacizumab sensitivity is warranted. (Source: BMC Cancer)

Extended Lymph Node Excision Feasible in Gastric Cancer

MedPage Today Gastroenterology — Tue, 24 Jan 2012 16:30:21 +0100

SAN FRANCISCO (MedPage Today) -- In patients with gastric cancer, laparoscopic gastrectomy that includes removal of lymph nodes outside the immediate area around the stomach offered "excellent" margin status and node retrieval, researchers reported here. (Source: MedPage Today Gastroenterology)

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DNA methylation status of REIC/Dkk-3 gene in human malignancies

Journal of Cancer Research and Clinical Oncology — Tue, 24 Jan 2012 12:27:14 +0100

Conclusions REIC/Dkk-3 type-a methylation was frequently detected in a broad range of cancers and appeared to play a key role in silencing REIC/Dkk-3 type-a expression in these malignancies. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-012-1158-6Authors Tatsuro Hayashi, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanHiroaki Asano, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanShinichi Toyooka, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharm...

Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer.

Autophagy — Tue, 24 Jan 2012 09:55:32 +0100

Authors: Zhou WH, Tang F, Xu J, Wu X, Yang SB, Feng ZY, Ding YG, Wan XB, Guan Z, Li HG, Lin DJ, Shao CK, Liu Q Abstract Recent studies have suggested that dysregulation of autophagy plays a pivotal role in tumorigenesis. Here, we determined the prognostic value of autophagy-related protein Beclin 1 in gastric cancer. A total of 153 primary gastric cancer patients were subjected to analysis of Beclin 1 expression and survival prognosis. Among them, 68 patients were assigned randomly and used as a training set to generate a cutoff score for Beclin 1 expression by receive operating characteristic (ROC) curve analysis. The ROC-generated cutoff score was subjected to analyze the association of Beclin 1 with clinical characteristics and patient outcome. In a testing set (n = 85) and over...

Morbidity and Mortality Results From a Prospective Randomized Controlled Trial Comparing Billroth I and Roux-en-Y Reconstructive Procedures After Distal Gastrectomy for Gastric Cancer

World Journal of Surgery — Tue, 24 Jan 2012 07:55:29 +0100

Conclusions We concluded that B-I reconstruction was superior to R-Y reconstruction in terms of perioperative complications. Content Type Journal ArticlePages 1-6DOI 10.1007/s00268-011-1408-9Authors Hiroshi Imamura, Department of Surgery, Sakai Municipal Hospital, Osaka, JapanShuji Takiguchi, Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871 JapanKazuyoshi Yamamoto, Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871 JapanMotohiro Hirao, Department of Surgery, Osaka National Hospital, Osaka, JapanJunya Fujita, Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, JapanIsao Miyashiro, Department of Surgery, Osaka ...

Multivariable Analysis of Cholecystectomy after Gastrectomy: Laparoscopy is a Feasible Initial Approach even in the Presence of Common Bile Duct Stones or Acute Cholecystitis

World Journal of Surgery — Tue, 24 Jan 2012 07:55:19 +0100

Conclusions The laparoscopic approach is feasible for cholecystectomy after gastrectomy, even in cases with CBD stones or acute cholecystitis. This approach does not appear to increase operation time or complication rate and was shown to decrease the length of postoperative hospital stay. Content Type Journal ArticlePages 1-7DOI 10.1007/s00268-012-1429-zAuthors Joohyun Kim, Department of Surgery, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701 KoreaJeong Nam Cho, Department of Surgery, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701 KoreaSun Hyung Joo, Department of Surgery, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 130-701 KoreaBum Soo Kim,...

MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4

Journal of Cancer Research and Clinical Oncology — Tue, 24 Jan 2012 07:30:41 +0100

Conclusion In summary, the data indicated that miR-223 targets FBXW7/hCdc4 expression at the post-transcriptional level and appears to regulate cellular apoptosis, proliferation, and invasion in gastric cancer. MiR-223 may serve as a novel therapeutic target in gastric cancer. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-012-1154-xAuthors Jinhai Li, Department of Gastrointestinal Surgery, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029 Jiangsu, People’s Republic of ChinaYuanyuan Guo, Department of Biochemistry and Molecular Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210002 Jiangsu, People’s Republic of ChinaXiaodi Liang, Department of Biochemistry and Molecular ...

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Safe laparoscopic resection of a gastric gastrointestinal stromal tumor close to the esophagogastric junction

Surgery Today — Tue, 24 Jan 2012 07:29:04 +0100

We describe our procedure, in which the whole layer of the gastric wall was cut, maintaining a sufficient margin and confirming the distance between the tumor and the EGJ, by endoscopy and laparoscopy. The defect in the gastric wall was closed using linear staplers by hanging up the stay sutures. Five patients with GIST close to EGJ underwent this procedure, followed by a good postoperative course. Thus, we consider our procedure to be safe and effective for gastric GISTs close to the EGJ. Content Type Journal ArticleCategory How to Do ItPages 1-4DOI 10.1007/s00595-012-0121-0Authors Yasuo Sakamoto, Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395 JapanYoshihisa Sakaguchi, Department of Gastroenterological Surger...

A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption. (Source: Annals of Oncology)

External validation of nomogram for the prediction of recurrence after curative resection in early gastric cancer

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: A preexisting nomogram for predicting disease-free survival (DFS) of EGC after surgery was externally validated. The nomogram is useful for accurate and individual prediction of DFS, patient prognostication, counseling, and follow-up planning. (Source: Annals of Oncology)

Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: We show that MSS SBAs are more similar to colorectal than to gastric cancer, based on the 27 genome-wide DNA copy number profiles that are currently available. These molecular similarities provide added support for treatment of MSS small bowel cancers according to colorectal cancer regimens. (Source: Annals of Oncology)

Survival from common and rare cancers in Germany in the early 21st century

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: German cancer survival estimates are mostly higher than the 2000–2002 pan-European estimates. Further research is needed to investigate causes responsible for differences between German and USA cancer survival rates. (Source: Annals of Oncology)

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Dietary cholesterol intake and cancer

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: Our findings add to the evidence that high cholesterol intake is linked to increased risk of various cancers. A diet low in cholesterol may play a role in the prevention of several cancers. (Source: Annals of Oncology)

Gastric Ca Survival Rates Down, Chemo Use Up

MedPage Today Gastroenterology — Mon, 23 Jan 2012 15:30:00 +0100

SAN FRANCISCO (MedPage Today) -- A decline in survival rates in stage IV gastric cancer coincides with the increased use of chemotherapy rather than radiation and surgery, researchers found. (Source: MedPage Today Gastroenterology)

The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7/20+ phenotype is more spesific than CDX2 antibody

Diagnostic Pathology — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: Both the CK7/CK20+ phenotype and expression of the antibody CDX2 are highly specific and sensitive markers of colorectal origin. CDX2 expression should be a useful adjunct for the diagnosis of intestinal adenocarcinomas, particularly when better established markers such as CK7 and CK20 yield equivocal results. The CK7/CK20+ phenotype is superior in its specificity and positive predictive value and might be preferred.Virtual slides:The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/4851011866354821 (Source: Diagnostic Pathology)

Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms

Endoscopy — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: Continuous aspirin use increases the risk of bleeding after gastric ESD. Aspirin use should be stopped in patients with a low risk for thromboembolic disease to minimize bleeding complications.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Endoscopy)

Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer

Endoscopy — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: Although our single-center retrospective study may be considered to be only preliminary, our data indicate that ESD for UD-EGC may yield good long-term outcomes.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Endoscopy)

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Evaluation of apoptosis along with BCL-2 and Ki-67 expression in patients with intestinal metaplasia.

Pathology, Research and Practice — Mon, 23 Jan 2012 05:00:00 +0100

Authors: Erkan G, Gonul II, Kandilci U, Dursun A Abstract The primary aim is to compare individuals with intestinal metaplasia (IM), chronic active gastritis (CAG), and normal gastric mucosa (NGM) in terms of apoptosis, proliferation, and Bcl-2 expression. The secondary aim is to determine whether these parameters are different between patients with and without gastric cancer in first-degree relatives. We enrolled 106 patients whose histopathological results were consistent with IM (n: 42), CAG (n: 51), or NGM (n: 13). Antral biopsies were immunohistochemically stained for Bcl-2 and Ki-67 expression. Apoptosis was detected using TUNEL assay. While no significant difference was determined between three groups with regard to apoptosis and Bcl-2 expression (p>0.05), Ki-67 expressio...

Tesetaxel shows efficacy against gastric cancer in study

Drug Development Technology — Mon, 23 Jan 2012 00:00:00 +0100

Genta Incorporated has announced positive results from the Phase 2b confirmatory clinical trial, designed to evaluate tesetaxel in treating patients with advanced gastric cancer. (Source: Drug Development Technology)

Oral Taxane Shows Promise in Stomach Cancer

MedPage Today Gastroenterology — Sun, 22 Jan 2012 02:48:04 +0100

SAN FRANCISCO (MedPage Today) -- An investigational oral taxane was active against gastroesophageal cancers in the second-line setting, according to a dose-ranging study. (Source: MedPage Today Gastroenterology)

Drug No Help for Survival in Advanced Gastric Ca

MedPage Today Gastroenterology — Sun, 22 Jan 2012 02:47:29 +0100

SAN FRANCISCO (MedPage Today) -- Adding the targeted agent everolimus (Afinitor) to best supportive care in patients with advanced gastric cancer failed to significantly improve overall survival, a researcher said here. (Source: MedPage Today Gastroenterology)

[Pathology and classification of intraductal papillary mucinous neoplasms of the pancreas.]

Der Chirurg — Sat, 21 Jan 2012 05:00:00 +0100

Authors: Schlitter AM, Esposito I Abstract Intraductal papillary mucinous neoplasms (IPMN) are precursor lesions of ductal adenocarcinoma of the pancreas and one of the most common cystic entities in this organ. Branch and main duct types are further distinguished based on the tumor localization. An additional classification is based on the predominant architecture and immunohistochemical profile with four prognostic relevant subtypes, gastric, intestinal, pancreato-biliary and oncocytic. This review provides an overview about the malignant potential of the different subtypes and the prognosis of associated invasive tumors and gives recommendations for the pathological assessment of resection specimens with IPMNs. PMID: 22271052 [PubMed - as supplied by publisher] (Source: Der ...

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Rapid high‐performance liquid chromatography method for determination of tryptophan in gastric juice

Chinese Journal of Digestive Diseases — Fri, 20 Jan 2012 20:55:34 +0100

CONCLUSIONS: An HPLC method based on strong cation‐exchange restricted access columns for determination of concentration of tryptophan in gastric juice was developed. The method has excellent precision and stability. It is compatible with the analysis of gastric juice and has the potential to be used for gastric cancer screening. (Source: Chinese Journal of Digestive Diseases)

Future candidates for indications of Helicobacter pylori eradication: Do the indications need to be revised?

Journal of Gastroenterology and Hepatology — Fri, 20 Jan 2012 20:46:51 +0100

AbstractSince the discovery of Helicobacter pylori in 1982, the development of several treatment guidelines has allowed a consensus on the indications for H. pylori eradication. Beyond these currently accepted indications, including various upper gastrointestinal disorders and extragastric diseases, a significant amount of new information regarding H. pylori eradication is emerging. Certain types of acute gastritis, such as nodular gastritis, hypertrophic gastritis, Ménétrier's disease, hemorrhagic gastritis, and granulomatous gastritis are reversible after H. pylori eradication. Further, for chronic gastritis, closed‐type atrophic gastritis and complete‐type intestinal metaplasia appear to be more reversible after H. pylori eradication than open‐type atrophic gastritis and...

Magnetic nanoparticles for treatment of gastric cancer

Journal of Gastroenterology and Hepatology — Fri, 20 Jan 2012 20:46:46 +0100

See article in J. Gastroenterol. Hepatol. 2012; 27: 406–411. (Source: Journal of Gastroenterology and Hepatology)

Adverse Effects of GI Cancer Therapy Long-Lasting

MedPage Today Hematology/Oncology — Fri, 20 Jan 2012 20:43:07 +0100

SAN FRANCISCO (MedPage Today) -- Years after successful treatment for gastric or esophageal cancer, patients still have complications from therapy, researchers found. (Source: MedPage Today Hematology/Oncology)

GRANITE-1: Second-line everolimus did not extend OS for advanced gastric cancer

HemOncToday.com — Fri, 20 Jan 2012 13:43:00 +0100

(Source: HemOncToday.com)

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Free peritoneal tumor cells detection in gastric and colorectal cancer patients

Journal of Surgical Oncology — Fri, 20 Jan 2012 13:16:52 +0100

ConclusionsEpithelial immunoenrichment and immunofluorescence analysis allows unequivocal identification of the FPTC. The real time qRT‐PCR showed higher sensitivity for the detection of CEA and CK20 mRNA levels and confirmed its prognostic value in gastrointestinal cancers. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

Gastric Cancer — Fri, 20 Jan 2012 07:07:04 +0100

Conclusion Application of the SLN technique may be practical for early gastric cancer. The use of DUAL for identifying SLN may yield a lower FNR than either method alone, although statistical significance was not met. Content Type Journal ArticleCategory Review articlePages 1-12DOI 10.1007/s10120-011-0103-8Authors Roberta Cardoso, Division of Surgical Oncology, Sunnybrook Research Institute, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Suite T2-60, 2075 Bayview Ave, Toronto, ON M4N 3M5, CanadaAlina Bocicariu, Division of Surgical Oncology, Sunnybrook Research Institute, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Suite T2-60, 2075 Bayview Ave, Toronto, ON M4N 3M5, CanadaMatthew Dixon, Division of Surgical Oncology, Sunnybrook Research Institu...

A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley

Indian Journal of Human Genetics — Fri, 20 Jan 2012 05:00:00 +0100

Conclusions: Polymorphism in CASP8 -652 6N ins/del polymorphism modulates the risk of EC and GC in Kashmir valley. (Source: Indian Journal of Human Genetics)

New Clinical Trial Confirms the Activity of Tesetaxel in Patients With Advanced Gastric Cancer

Medical News (via PRIMEZONE) — Thu, 19 Jan 2012 13:05:00 +0100

BERKELEY HEIGHTS, N.J., Jan. 19, 2012 (GLOBE NEWSWIRE) -- Genta Incorporated (OTCBB:GNTA.OB) today announced results from the Company's Phase 2b, confirmatory clinical trial of tesetaxel in patients with advanced gastric cancer. The trial is lead by investigators from M.D. Anderson Cancer Center, Houston, TX, in collaboration with Northwestern University, Chicago, IL, University of Pennsylvania, Philadelphia, PA, and the Severance Hospital, Seoul, Korea. The data are being presented this week at the GI Cancer Symposium in San Francisco, CA, sponsored by the American Society of Clinical Oncology (ASCO). (Source: Medical News (via PRIMEZONE))

Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models

Surgical Endoscopy — Thu, 19 Jan 2012 08:04:51 +0100

Conclusions The PES combination inhibited subcutaneous and hepatic tumor growth yet did not impair wound healing. PES holds promise as a perioperative anticancer therapy. Content Type Journal ArticlePages 1-9DOI 10.1007/s00464-011-2114-2Authors Xiaohong Yan, Colon & Rectum Surgery, St. Luke’s Roosevelt Hospital Center, 432 West, 58th Street, Room 517, New York, NY 10019, USAThomas R. Gardner, Orthopaedic Surgery, Columbia University, 630 West, 168th Street, Black building 14th Floor, New York, NY 10032, USAMichael Grieco, Surgery, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ 07039, USASonali A. C. Herath, Colon & Rectum Surgery, St. Luke’s Roosevelt Hospital Center, 432 West, 58th Street, Room 517, New York, NY 10019, USAJoon Ho Jang, Co...

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Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma

British Journal of Cancer AOP — Thu, 19 Jan 2012 05:00:00 +0100

Authors: H Konishi, D Ichikawa, S Komatsu, A Shiozaki, M Tsujiura, H Takeshita, R Morimura, H Nagata, T Arita, T Kawaguchi, S Hirashima, H Fujiwara, K Okamoto & E Otsuji (Source: British Journal of Cancer AOP)

Activation of lytic cycle of Epstein‐Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma

International Journal of Cancer — Thu, 19 Jan 2012 05:00:00 +0100

We reported that suberoylanilide hydroxamic acid (SAHA) induced EBV lytic cycle in EBV‐positive gastric carcinoma cells and mediated enhanced cell death. However, expression of EBV lytic proteins was thought to exert anti‐apoptotic effect in EBV‐infected cells. Here, we examined the in vitro and in vivo effects of SAHA on EBV lytic cycle induction in NPC cells and investigated the cellular consequences. Micromolar concentrations of SAHA significantly induced EBV lytic cycle in EBV‐positive NPC cells. Increased apoptosis and proteolytic cleavage of PARP, caspase‐3, ‐7 and ‐9 in EBV‐positive versus EBV‐negative NPC cells were observed. >85% of NPC cells expressing immediate‐early (Zta), early (BMRF1) or late (gp350/220) lytic proteins co‐expressed cleaved caspase‐3...

Docetaxel and Cisplatin plus Fluorouracil compared with modified docetaxel, Cisplatin, and 5-Fluorouracil as first-line therapy for advanced gastric cancer: a retrospective analysis of single institution.

Neoplasma — Thu, 19 Jan 2012 04:30:02 +0100

In conclusion, the response rate, median PFS and median OS are similar in both arms, while the mDCF regimen are more favorable than the DCF for toxicity profile regimen in advanced gastric cancer patients who were undergoing first-line palliative treatment. Therefore, a prospective and larger clinical trials are needed. Keywords: advanced gastric cancer, docetaxel, cisplatin, fluorouracil. PMID: 22248282 [PubMed - in process] (Source: Neoplasma)

Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells.

Neoplasma — Thu, 19 Jan 2012 04:30:02 +0100

In conclusion, the major role of DCP is the moderate confirmation of HCC. More prospective studies of DCP are needed in future. Keywords: gastric cancer, proton pump inhibitors, HIF-1α PMID: 22248271 [PubMed - in process] (Source: Neoplasma)

Endoscopic Submucosal Dissection for Undifferentiated Early Gastric Cancer as the Expanded Indication Lesion

Digestion — Wed, 18 Jan 2012 23:00:00 +0100

Digestion 2012;85:111–115 (DOI:10.1159/000334681) (Source: Digestion)

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Esophageal Cancer May Be Caused By Migration Of Cancer-Causing Stomach Cells

Health News from Medical News Today — Wed, 18 Jan 2012 10:00:00 +0100

A new study is providing clues that may answer a decades-old question about the cells that give rise to a particularly lethal form of esophageal cancer. The research, published by Cell Press in the January 17th issue of the journal Cancer Cell, links inflammation and bile acid reflux with migration of cancer-causing stomach cells into the esophagus and may help guide future strategies for early therapeutic intervention. Esophageal adenocarcinoma is a cancer of the esophagus that is associated with acid reflux disease and Barrett esophagus (BE)... (Source: Health News from Medical News Today)

Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas

Gastric Cancer — Wed, 18 Jan 2012 06:52:05 +0100

Conclusions ME–NBI is useful in planning the management of lesions diagnosed as adenomas by pre-treatment forceps biopsy. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s10120-011-0133-2Authors Yosuke Tsuji, Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625 JapanKen Ohata, Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625 JapanMasau Sekiguchi, Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625 JapanAkiko Ohno, Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625 JapanTakafumi Ito, Department of Gastroe...

Efficacy of weekly paclitaxel in patients with advanced gastric cancer refractory to docetaxel-based chemotherapy

Gastric Cancer — Wed, 18 Jan 2012 06:52:04 +0100

Conclusions Weekly paclitaxel was modestly active in patients with gastric cancer refractory to docetaxel-based chemotherapy. Content Type Journal ArticleCategory Original articlePages 1-6DOI 10.1007/s10120-011-0135-0Authors Takayuki Ando, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194 JapanAyumu Hosokawa, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194 JapanShinya Kajiura, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194 JapanYuko Itaya, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 93...

Decreased number and reduced NKG2D expression of Vδ1 γδ T cells are involved in the impaired function of Vδ1 γδ T cells in the tissue of gastric cancer

Gastric Cancer — Wed, 18 Jan 2012 06:52:03 +0100

Conclusion Vδ1 γδ T cells show decreased frequency and impaired function in gastric cancer tissue, for which decreased NKG2D expression might be one of the mechanisms. Modalities specifically targeting NKG2D in Vδ1 γδ T cells may provide a breakthrough treatment for gastric cancer patients. Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s10120-011-0138-xAuthors Hirohiko Kuroda, Division of Surgical Oncology, Department of Surgery, Tottori University School of Medicine, 36-1 Nishi-cho, Yonago, 683-8504 JapanHiroaki Saito, Division of Surgical Oncology, Department of Surgery, Tottori University School of Medicine, 36-1 Nishi-cho, Yonago, 683-8504 JapanMasahide Ikeguchi, Division of Surgical Oncology, Department of Surgery, Tottori Univ...

Descriptive epidemiology of gastric adenocarcinoma in the State of Texas by ethnicity: Hispanic versus White non-Hispanic

Gastric Cancer — Wed, 18 Jan 2012 06:52:03 +0100

Conclusion The incidence of gastric adenocarcinoma is higher in Hispanics than in Whites in both El Paso County and the remaining portion of Texas. Hispanics have a higher grade of gastric adenocarcinoma. The prevalence of late stage at the time of diagnosis is higher in younger patients than in older patients. Content Type Journal ArticleCategory Original articlePages 1-9DOI 10.1007/s10120-011-0127-0Authors Babak Rajabi, Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USAJavier C. Corral, Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USANawar Hakim, Department of Pathology, Paul L. Foster School of Medicine,...

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Patient heterogeneity and allocation bias: how should they be reported in clinical trials of chemotherapy for advanced gastric cancer?

Gastric Cancer — Wed, 18 Jan 2012 06:52:03 +0100

Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s10120-011-0130-5Authors Ichinosuke Hyodo, Division of Gastroenterology, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 (Source: Gastric Cancer)

Vitamin A and gastric cancer risk

Gastric Cancer — Wed, 18 Jan 2012 06:52:02 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s10120-011-0137-yAuthors Levent Filik, Gastroenterology Division, Ankara Research Hospital, Ulucanlar, Altindag, Ankara 06600, Turkey Journal Gastric CancerOnline ISSN 1436-3305Print ISSN 1436-3291 (Source: Gastric Cancer)

Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute

Gastric Cancer — Wed, 18 Jan 2012 06:52:01 +0100

Conclusion Early detection and curative operations are essential for improving the prognosis of gastric EC. However, some adjuvant chemotherapies are required for advanced-stage tumors. Classification and staging systems may need to be unified worldwide for further analysis. Content Type Journal ArticleCategory Original articlePages 1-8DOI 10.1007/s10120-011-0122-5Authors Takeshi Kubota, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550 JapanShigekazu Ohyama, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550 JapanNaoki Hiki, Department of Gastroenterological Surgery, C...

Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells

Clinical and Experimental Metastasis — Wed, 18 Jan 2012 06:48:28 +0100

In conclusion, these results may contribute to the JunB-associated malignant phenotype of gastric cancers by regulating MMP-9, and serve as a novel therapeutic target for stomach cancer therapy in the future. Content Type Journal ArticleCategory Research PaperPages 1-10DOI 10.1007/s10585-011-9449-xAuthors Kyung Hee Lee, Department of Hematology-Oncology, College of Medicine, Yeungnam University, Daegu, Republic of KoreaJae-Ryong Kim, Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 317-1 Daemyung-Dong, Daegu, 705-717 Republic of Korea Journal Clinical and Experimental MetastasisOnline ISSN 1573-7276Print ISSN 0262-0898 (Source: Clinical and Experimental Metastasis)

Stomach Cells and Esophageal Cancer

Medical Headlines From Ivanhoe.com — Wed, 18 Jan 2012 05:00:00 +0100

(Ivanhoe Newswire)-- Experiments involving mice help provide new insight into what may cause a lethal form of esophageal cancer. (Source: Medical Headlines From Ivanhoe.com)

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Phase III Trial Comparing Capecitabine Plus Cisplatin Versus Capecitabine Plus Cisplatin With Concurrent Capecitabine Radiotherapy in Completely Resected Gastric Cancer With D2 Lymph Node Dissection: The ARTIST Trial [Gastrointestinal Cancer]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion The addition of XRT to XP chemotherapy did not significantly reduce recurrence after curative resection and D2 lymph node dissection in gastric cancer. A subsequent trial (ARTIST-II) in patients with lymph node–positive gastric cancer is planned. (Source: Journal of Clinical Oncology)

Participation and conflict in the decision‐making process for endoscopic resection or surgical gastrectomy for early gastric cancer

Journal of Surgical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

ConclusionDespite the high overall decisional conflict, patients with preference for endoscopic treatment tended to be more autonomous. After consultation, all patients exhibited a passive participation role in the decision‐making process. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

A poly(glycerol-sebacate-(5-fluorouracil-1-acetic acid)) polymer with potential use for cancer therapy

Journal of Bioactive and Compatible Polymers — Wed, 18 Jan 2012 05:00:00 +0100

In this study, 5-fluorouracil-1-acetic acid was chemically conjugated with poly(glycerol-sebacate) (PGS) to form a unitary polymer poly(glycerol-sebacate- (5-fluorouracil-1-acetic acid)) (PGS-5-FU-CH2COOH). The structure, the in vitro antitumor activity of 5-FU-CH2COOH, the in vitro degradation, the drug release, and antitumor activity as well as the in vivo degradation and tissue biocompatibility of PGS-5-FU-CH2COOH were investigated. The 5-FU-CH2COOH inhibited HeLa (human cervical cancer cell line) and SGC-7901 (human gastric adenocarcinoma cell line) tumor cells with a half maximal inhibitory concentration (IC50) of 0.196 and 0.267 μM, respectively, after a 3-day incubation. The in vitro drug release profiles of PGS-5-FU-CH2COOH exhibited a biphasic release with an initial exponentia...

Survivin Knockdown Enhances Gastric Cancer Cell Sensitivity to Radiation and Chemotherapy In Vitro and in Nude Mice.

The American Journal of the Medical Sciences — Wed, 18 Jan 2012 05:00:00 +0100

CONCLUSIONS: Knockdown of survivin expression enhanced sensitivity of gastric cancer cells to radiation, cisplatin and 5-FU treatment in vitro and in nude mice. These results demonstrate that clinical trails are warranted of survivin shRNA as an adjuvant therapy for gastric cancer patients. PMID: 22261621 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

Early additional endoscopic submucosal dissection in patients with positive lateral resection margins after initial endoscopic submucosal dissection for early gastric cancer

Gastrointestinal Endoscopy — Tue, 17 Jan 2012 22:04:55 +0100

We report the usefulness of early additional ESD in patients with positive lateral resection margins after initial ESD for EGCs. (Source: Gastrointestinal Endoscopy)

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Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

Cancer Cell — Tue, 17 Jan 2012 00:00:00 +0100

Michael Quante, Govind Bhagat, Julian A. Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles J. Lightdale, Anil K. Rustgi, Timothy C. Wang. Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression o.... (Source: Cancer Cell)

New Gastroprotective Labdeneamides from (4S,9R,10R) Methyl 18-carboxy-labda-8,13(E)-diene-15-oate

Planta Medica — Mon, 16 Jan 2012 05:00:00 +0100

Planta MedDOI: 10.1055/s-0031-1280453AbstractStarting from the diterpene (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-dien-15-oate (PMD) and its 8(9)-en isomer [PMD 8(9)-en], 11 amides were prepared and assessed for a gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice. Basal cytotoxicity of the compounds was determined on the following human cell lines: normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). All compounds are described for the first time. At the single oral dose of 0.1 mg/kg, compounds 1, 10, and 11 presented a strong gastroprotective effect, at least comparable with that of the reference compound lansoprazole at 1 mg/kg, reducing gastric lesions by 76.7, 67.7, and 77.2 %, respectiv...

Acute Liver Failure Secondary to Metastatic Medullary Thyroid Cancer

Journal of Biophysics — Mon, 16 Jan 2012 03:35:01 +0100

We present a 59-year-old male with newly diagnosed MTC, who was admitted with ALF. He presented with jaundice, hepatic encephalopathy, and synthetic dysfunction. His clinical course was marked by rapid decompensation within 6 days from initial presentation of jaundice to development of hepatic coma. Although liver metastases from medullary thyroid cancer have been reported, to our knowledge, this is the first described case of MTC resulting in acute liver failure. (Source: Journal of Biophysics)

Atypical Neurofibroma and Osteosclerotic Metastasis

Journal of Biophysics — Mon, 16 Jan 2012 03:35:01 +0100

35-year-old male presented with multiple swellings in left leg, headache, weakness of limbs for 4 months, and blurring of vision for the last 15 days. On examination, he was pale, cachexic with generalized lymphadenopathy and lower motor neuron type weakness of limbs sparing right upper limb. Blood investigations showed anemia with high alkaline phosphatase. Chest radiograph revealed osteosclerotic metastatic lesion in humerus. Biopsy of leg lesion revealed atypical neurofibroma. Computed tomography (CT) of thorax revealed osteoblastic metastasis. Bone marrow aspiration showed cells with round to oval nuclei, fine granular chromatin with large central prominent nucleoli and eosinophilic cytoplasm with acini formation. Magnetic resonance imaging (MRI) of brain and spinal cord defined metast...

Prognostic Significance of CD44 Expression in Patients with Advanced T3/4 Gastric Adenocarcinoma

Journal of Surgical Research — Sat, 14 Jan 2012 22:30:08 +0100

(Source: Journal of Surgical Research)

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Gastrointestinal Cancers in Young Survivors of Lymphoma: Implications for Earlier Screening

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:56 +0100

This study sought to determine if patients diagnosed under the age of 40 would benefit from earlier screening for gastrointestinal (GI) malignancies. Methods: Analysis of the Surveillance Epidemiology and End Results (SEER) database using data accrued from 1973-2008. Patients younger than 40 years old who were diagnosed with Hodgkin's (HL) or Non-Hodgkin's Lymphoma (NHL) between 1973 and 1993 were included. the incidence of various GI cancers in these patients was obtained. Standardized incidence ratios using the SEERStat software were generated to identify more frequent and early age-onset second malignancies in this cohort. Results: In this time period, 27,339 HL patients and 138,474 NHL patients were identified, among whom 8,892 HL and 7,606 NHL patients were less than 40 years old. The...

Diagnosis of Venous Thromboembolism as an Outpatient in Patients Undergoing Surgical Treatment for Malignancy: An Analysis of ACS NSQIP Data 2005-2008

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:46 +0100

Conclusions: Extended VTE pharmacoprophylaxis should be considered for patients with malignancies with a high incidence of VTE diagnosis after discharge, such as malignancies of the pancreas, stomach and prostate. Future studies to determine the impact of extending VTE prophylaxis on rates of VTE and re-admission or complications of bleeding are needed. (Source: Journal of Surgical Research)

Zerumbone Inhibits Tumor Angiogenesis in Gastric Cancer

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:56 +0100

(Source: Journal of Surgical Research)

The Timing of Chemotherapy Correlates With Survival in Patients With Resectable Gastric Adenocarcinoma

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:56 +0100

(Source: Journal of Surgical Research)

Hereditary diffuse gastric cancer: The always-forgotten Meckel’s diverticulum

Surgery — Sat, 14 Jan 2012 22:27:59 +0100

The aim of prophylactic surgery is to remove as much of the at-risk tissue as possible to reduce the chances of developing cancer in the at risk tissue. This point is made clear by Pandalai et al in their study of patients with CDH1 mutations, where total gastrectomy is performed to excise all the at risk gastric mucosa. For this reason, partial gastrectomy is contraindicated in these patients, and the total gastrectomy is performed with a resection line across the distal esophagus to ensure no gastric cardia mucosa is left behind. (Source: Surgery)

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Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology.

World Journal of Gastroenterology : WJG — Sat, 14 Jan 2012 05:00:00 +0100

CONCLUSION: In gastric cancer, HER2 amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases. PMID: 22253521 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Characterization of gastric cancer models from different cell lines orthotopically constructed using improved implantation techniques.

World Journal of Gastroenterology : WJG — Sat, 14 Jan 2012 05:00:00 +0100

CONCLUSION: Models using the SGC-7901 and BGC-823 cell lines were established which could function in gastric cancer research on carcinogenesis mechanism and drug discovery. The two models showed different tumor behavior and the latter was more malignant than the former. PMID: 22253519 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells.

Molecular and Cellular Biochemistry — Sat, 14 Jan 2012 05:00:00 +0100

Authors: Zha L, Wang Z, Tang W, Zhang N, Liao G, Huang Z Abstract High mobility group protein A2 (HMGA2) is an architectural transcription factor that plays an important role in development and progression of malignant neoplasias. Recently, some studies reported that HMGA2 is also implicated in epithelial-mesenchymal transitions (EMT) and cancer stem cells. But the underlying mechanisms of these conditions are poorly understood. Therefore, we established an EMT model of gastric carcinoma cells by overexpressing HMGA2 in vitro, then global mapping of HMGA2 potential transcription factor binding sites was identified by promoter microarray in these cells, and the date obtained from the microarrays were validated via chromatin immunoprecipitation-PCR (ChIP-PCR) and real-time PCR. HMGA2...

Evaluation of the Seventh Edition of American Joint Committee on Cancer TNM Staging System for Gastric Cancer: Results from a Chinese Monoinstitutional Study

Annals of Surgical Oncology — Fri, 13 Jan 2012 16:56:41 +0100

Conclusions It is reasonable to subclassify the 6th edition pT2 category and pN1 category into the 7th edition pT2/pT3 category and pN1/pN2 category, respectively. However, for better prognostic stratification, it might be more suitable for pN3a and pN3b categories to be considered individual determinants of the 7th edition TNM staging system. Content Type Journal ArticleCategory Gastrointestinal OncologyPages 1-10DOI 10.1245/s10434-011-2206-1Authors Zhe Sun, Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, ChinaZhen-ning Wang, Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, ChinaZhi Zhu, Department of Surgical Oncology, First Affiliated Hospital of China Medical Unive...

The Role of SPARC Protein Expression in the Progress of Gastric Cancer.

Pathology Oncology Research — Fri, 13 Jan 2012 05:00:00 +0100

Authors: Wang L, Yang M, Shan L, Qi L, Chai C, Zhou Q, Yao K, Wu H, Sun W Abstract We aimed to investigate the expression of SPARC (secreted protein, acidic and rich in cysteine) in gastric cancer and its relationship with tumor angiogenesis and cancer cells proliferation. Protein expression of SPARC, VEGF, CD34 and Ki-67 in 80 cases of gastric cancer and 30 cases of normal gastric tissue was evaluated by immunohistochemistry. CD34 staining was used as an indicator of microvessel density (MVD). Ki-67 labeling Index (LI) indicated cancer cells proliferation. Statistical analysis was used to investigate its relationship with clinical characteristics, tumor angiogenesis and cancer cells proliferation. SPARC expression was mainly in the stromal cells surrounding the gastric cancer cell...

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Usefulness and pitfalls of MAA SPECT/CT in identifying digestive extrahepatic uptake when planning liver radioembolization

European Journal of Nuclear Medicine and Molecular Imaging — Thu, 12 Jan 2012 06:42:34 +0100

Conclusion SPECT/CT is more efficacious than planar imaging in identifying digestive extrahepatic uptake sites, with extrahepatic uptake observed in one third of scans using the former procedure. However, more than half of the uptake sites in our study were vascular in nature, without therapeutic implications. The risk of coregistration errors must also be kept in mind. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00259-011-2033-4Authors Laurence Lenoir, Department of Nuclear Medicine, Comprehensive Cancer Institute Eugène Marquis, CS 44229, 35042 Rennes, FranceJulien Edeline, University of Rennes 1, 35043 Rennes, FranceYann Rolland, Department of Medical Imaging, Comprehensive Cancer Institute Eugène Marquis, CS 44229, 35042 Rennes, ...

Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study.

BMC Cancer — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions: An increased focus on prevention and early diagnosis, especially in deprived areas and in males, is required to improve outcomes for these cancers. Improved recording of tumour site, stage and morphology and the evaluation of focused early diagnosis programmes are also needed. The poor long-term survival reinforces the need for early detection and multidisciplinary care. (Source: BMC Cancer)

Serum biomarker panels for the diagnosis of gastric adenocarcinoma

British Journal of Cancer AOP — Thu, 12 Jan 2012 05:00:00 +0100

Authors: H S Ahn, Y S Shin, P J Park, K N Kang, Y Kim, H-J Lee, H-K Yang & C W Kim (Source: British Journal of Cancer AOP)

FGFR2 gene amplification and clinicopathological features in gastric cancer

British Journal of Cancer AOP — Thu, 12 Jan 2012 05:00:00 +0100

Authors: K Matsumoto, T Arao, T Hamaguchi, Y Shimada, K Kato, I Oda, H Taniguchi, F Koizumi, K Yanagihara, H Sasaki, K Nishio & Y Yamada (Source: British Journal of Cancer AOP)

Prolyl Hydroxylase Domain 2 Protein Is a Strong Prognostic Marker in Human Gastric Cancer

Pathobiology — Wed, 11 Jan 2012 23:00:00 +0100

Pathobiology 2012;79:11–17 (DOI:10.1159/000330170) (Source: Pathobiology)

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Sequential chemotherapy with cisplatin, leucovorin, and 5-fluorouracil followed by docetaxel in previously untreated patients with metastatic gastric cancer: a phase II study

Gastric Cancer — Wed, 11 Jan 2012 17:52:12 +0100

Conclusions For patients with metastatic gastric cancer, the sequential administration of cisplatin, leucovorin, 5-FU, and docetaxel may be an effective palliative option and offers a far more favorable toxicity profile than the simultaneous use of docetaxel, cisplatin, and 5-FU. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10120-011-0134-1Authors Vincenzo Catalano, U.O.C. Oncologia, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Presidio San Salvatore, Via Lombroso, 61122 Pesaro, ItalyBruno Vincenzi, Oncologia Medica, Università Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, ItalyPaolo Giordani, U.O.C. Oncologia, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Presidio San Salvatore, Via Lombroso, 61122 P...

Adenovirus-mediated expression of p33ING1b induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro

Gastric Cancer — Wed, 11 Jan 2012 17:52:12 +0100

Conclusions Down-regulation of p33ING1b might play an important role in the development of gastric adenocarcinoma. Targeted local expression of p33ING1b may offer a promising alternative therapeutic measure for gastric cancer. Content Type Journal ArticleCategory Original articlePages 1-8DOI 10.1007/s10120-011-0123-4Authors Yifei Lv, Department of Gastroenterology, 1st Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710061 Xi’an, ChinaBibek Kumar Purbey, Department of Gastroenterology, 1st Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710061 Xi’an, ChinaYanhua Huang, Department of Gastroenterology, 1st Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710061 Xi’an, ChinaShuang Li, Department of Ga...

Comparative analysis of the efficacy and safety of chemotherapy with oxaliplatin plus fluorouracil/leucovorin between elderly patients over 65 years and younger patients with advanced gastric cancer

Gastric Cancer — Wed, 11 Jan 2012 17:52:12 +0100

Conclusions mFOLFOX6 maintains its efficacy and safety in elderly patients aged over 65 years in comparison with AGC patients aged <65 years. Its judicious use should be considered regardless of age. Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s10120-011-0128-zAuthors Yo Han Cho, Department of Hemato-oncology, Konkuk University Medical Center, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaSung Yong Kim, Department of Hemato-oncology, Konkuk University Medical Center, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaM. Hong Lee, Department of Hemato-oncology, Konkuk University Medical Center, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaMoon-Won Yoo, Department of General Surgery...

A systematic review and meta-analysis of the utility of EUS for preoperative staging for gastric cancer

Gastric Cancer — Wed, 11 Jan 2012 17:52:10 +0100

Conclusion EUS is a moderately accurate technique that seems to describe advanced T stage (T3 and T4) better than N or less advanced T stage. Stratifying by EUS annual volume did not affect EUS performance in staging gastric cancer. Content Type Journal ArticleCategory Review articlePages 1-8DOI 10.1007/s10120-011-0115-4Authors Roberta Cardoso, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, CanadaNatalie Coburn, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, CanadaRajini Seevaratnam, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, CanadaRinku Sutradhar, Institute for Clinical Evaluative Sciences, Toronto, CanadaLaercio Gomes Lourenco, Department of Surgery, Federal University of Sao Pa...

A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach

Gastric Cancer — Wed, 11 Jan 2012 17:52:09 +0100

Conclusions The MAb MUC1-014E is very useful for accurate detection of isolated cancer cells in scirrhous gastric cancers. Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s10120-011-0125-2Authors Suguru Yonezawa, Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 JapanShinichi Kitajima, Department of Surgical Pathology, Kagoshima University Hospital, Kagoshima, JapanMichiyo Higashi, Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 JapanMasahiko Osako, Department of Surgery, Kagoshima-shi Medical Association Hospital, Kagoshima, J...

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Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection

Gastric Cancer — Wed, 11 Jan 2012 17:52:09 +0100

Conclusions We identified seven novel gastric cancer risk markers that are highly informative in individuals with past infection. Content Type Journal ArticleCategory Original articlePages 1-7DOI 10.1007/s10120-011-0126-1Authors Sohachi Nanjo, Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanKiyoshi Asada, Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanSatoshi Yamashita, Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanTakeshi Nakajima, Gastrointestinal Endoscopy Division, National Cancer Center Hospital, Tokyo, JapanKazuyuki Nakazawa, Second Department of Internal Medicine, Waka...

Gastric cancer in Africa: what do we know about incidence and risk factors?

Transactions of the Royal Society of Tropical Medicine and Hygiene — Wed, 11 Jan 2012 11:11:30 +0100

Abstract: Gastric cancer is a major contributor to mortality worldwide, yet its incidence varies widely around the world in a way which our current understanding of aetiology cannot fully explain. Incidence data from Africa are weak, reflecting poor diagnostic resources, but there are firm data on intestinal metaplasia and gastric atrophy which are important steps in the carcinogenesis pathway. The available registry data suggest that incidence is unlikely to be dramatically different from Europe or North America. Helicobacter pylori infection is an important permissive factor in the development of cancer, but H. pylori seroprevalence is high all over Africa and cannot clearly be correlated with cancer. However, there is evidence that specific bacterial virulence genes, particularly vacA a...

Subdiaphragmatic bronchogenic cyst of the esophagus masquerading as a metastatic lymph node of coexisting advanced gastric cancer

Esophagus — Tue, 10 Jan 2012 17:00:52 +0100

Abstract Esophageal bronchogenic cysts are rare bronchopulmonary foregut malformations, and those located in the abdominal cavity are particularly rare. Esophageal cysts are typically found incidentally; an exact preoperative diagnosis of bronchogenic cyst is difficult, and surgical resection is generally recommended. Here, we report a case in which a subdiaphragmatic bronchogenic cyst of the esophagus coexisted with advanced gastric cancer. A 44-year-old man was referred for the treatment of gastric cancer. A preoperative examination revealed a mass on the right side of the esophagogastric junction that was preoperatively diagnosed as a metastatic lymph node. Intraoperative exploration revealed that the mass had protruded from the abdominal esophageal wall, and was diagno...

Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer

Clinical and Experimental Medicine — Tue, 10 Jan 2012 16:49:40 +0100

Abstract To study the inhibitory effect of nuclear transcription factor-kappa B(NF-κB) antisense oligodeoxynucleotide(ASODN) on the growth and tumorgenesis of human gastric cancer. We synthesized and transfected the ASODN of NF-κB/P65 to gastric cancer cell line. The effect of ASODN of NF-κB/P65 on the proliferation of gastric cancer cells was measured by MTT method. The subcutaneous xenograft model of human gastric cancer was established in nude mice, and the tumor growth curve was observed. The cell proliferation was significantly inhibited in P65 ASODN-transfected group in vitro (P < 0.05). In vivo, tumor formation test showed that the tumor volume in nude mice in ASODN group was obviously smaller than in other groups (P < 0.05); the apoptosi...

Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: Induction of promoter demethylation and histone modification causing inhibition of Wnt signaling.

International Journal of Oncology — Tue, 10 Jan 2012 05:00:00 +0100

Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: Induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. Int J Oncol. 2012 Jan 10; Authors: Shin H, Kim JH, Lee YS, Lee YC Abstract Activation of Wnt signaling without mutation of β-catenin or APC occurs frequently in human gastric cancers. Secreted frizzled-related protein (SFRP), a negative modulator of the Wnt signaling pathway, are frequently inactivated in human gastric cancers. Inhibition of SFRP gene expression may account for the Wnt/β-catenin activation in human gastric cancer. However, the molecular mechanisms of silencing of SFRP genes are not fully understood. ...

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How a fluttery tummy could mean cancer

Daily Express - Health — Tue, 10 Jan 2012 00:00:00 +0100

WHEN Letitia Featherstone started getting butterflies in her stomach and lost her appetite she thought she was falling in love. (Source: Daily Express - Health)

Genotypic characterization of Helicobacter pylori isolates among Egyptian patients with upper gastrointestinal diseases

The Chinese-German Journal of Clinical Oncology — Mon, 09 Jan 2012 19:27:43 +0100

Conclusion The development of GC is linked to infection with H. pylori harboring certain virulence genes. Higher infection density of H. pylori was found in GC patients. Co-existence of more than one strain of H. pylori in the same patient occurs in both malignant and benign lesions. Content Type Journal ArticlePages 15-23DOI 10.1007/s10330-011-0880-xAuthors Abdel Hamid Hussein Ezzat, Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, EgyptMona Hamza Ali, Laboratory Forensic Medicine, Egyptian Ministry of Justice, Cairo, EgyptEman Ahmed El-Seidi, Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, EgyptIman Ezzat Wali, Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, E...

Mucinous Adenocarcinoma of Stomach

Diagnostic Imaging — Mon, 09 Jan 2012 12:00:00 +0100

Clinical History: An 84-year-old male patient, known case of HTN and dyslipidemia, complaining of dysphasia for three months. Anorexia and vomiting. Diagnosed as esophageal adenocarcinoma outside for evaluation. (Source: Diagnostic Imaging)

Targeted Therapies and Predictive Markers in Epithelial Malignancies of the Gastrointestinal Tract.

Archives of Pathology and Laboratory Medicine — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion.-Gene testing of critical elements of the pathways targeted by these agents (such as KRAS mutational analysis in colorectal tumors and HER2/neu testing in gastric cancers) allows the ability to predict which patients will respond to these treatments. As the molecular profiling of tumors and our understanding of cancer genomics and epigenetic alterations continues to grow, it is expected that these personalized targeted therapies will form one of the mainstays of gastrointestinal cancer treatment. PMID: 22229849 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)

Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.

Acta Pharmacologica Sinica — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion:Plumbagin inhibits cell growth and potentiates apoptosis in human GC cells through the NF-κB pathway. PMID: 22231395 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

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Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: Case report

World Journal of Surgical Oncology — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions: Although it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and post-operative diagnoses may be essential, and such cancer development is not considered to be unusual. (Source: World Journal of Surgical Oncology)

Abnormal expression of E‐cadherin in tumor cells is associated with poor prognosis of gastric carcinoma

Journal of Surgical Oncology — Mon, 09 Jan 2012 05:00:00 +0100

ConclusionWe found significant correlation among HGF/c‐Met, E‐cadherin expression and worse prognosis of patients with GC. Abnormal E‐cadherin expression may serve as an independent predictive factor for prognosis of GC patients. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

Overexpression of thrombospondin‐1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma

Journal of Surgical Oncology — Mon, 09 Jan 2012 05:00:00 +0100

ConclusionsThis clinical study revealed that overexpression of THBS‐1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma. THBS‐1 may activate latent transforming growth factor‐β1 to stimulate fibroblasts to differentiate into myofibroblasts, though further studies are needed to validate this hypothesis. These results suggest that THBS‐1 and myofibroblasts may serve as novel targets for strategies aimed at protection against and treatment of gastric carcinoma. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

LINE-1 hypomethylation in familial and sporadic cancer

Journal of Molecular Medicine — Sat, 07 Jan 2012 16:55:24 +0100

Abstract Increased and decreased methylation at specific sequences (hypermethylation and hypomethylation, respectively) is characteristic of tumor DNA compared to normal DNA and promotes carcinogenesis in multiple ways including genomic instability. Long interspersed element (LINE), an abundant class of retrotransposons, provides a surrogate marker for global hypomethylation. We developed methylation-specific multiplex ligation-dependent probe amplification assays to study LINE-1 methylation in cases of colorectal, gastric, and endometrial cancer (N = 276), stratified by patient category [sporadic; Lynch syndrome (LS); familial colorectal cancer type X (FCCX)] and microsatellite instability status. Within each patient group, LINE-1 showed lower methylation in tumor DNA ...

Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model

Clinical and Experimental Metastasis — Sat, 07 Jan 2012 16:52:12 +0100

Abstract ST6GalNAcI is a sialyltransferase responsible for the synthesis of sialyl Tn (sTn) antigen which is expressed in a variety of adenocarcinomas including gastric cancer especially in advanced cases, but the roles of ST6GalNAcI and sTn in cancer progression are largely unknown. We generated sTn-expressing human gastric cancer cells by ectopic expression of ST6GalNAcI to evaluate metastatic ability of these cells and prognostic effect of ST6GalNAcI and sTn in a mouse model, and identified sTn carrier proteins to gain insight into the function of ST6GalNAcI and sTn in gastric cancer progression. A green fluorescent protein-tagged human gastric cancer cell line was transfected with ST6GalNAcI to produce sTn-expressing cells, which were transplanted into nude mice. STn-po...

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Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest.

World Journal of Gastroenterology : WJG — Sat, 07 Jan 2012 05:00:00 +0100

CONCLUSION: The growth inhibitory effect of PBA on gastric cancer cells is associated with alteration of the cell cycle. For moderately-differentiated gastric cancer cells, the cell cycle was arrested at the G(0)/G(1) and G(2)/M phases. For lowly-differentiated gastric cancer cells, the cell cycle was arrested at the G(0)/G(1) and S phases. PMID: 22228974 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Germline promoter hypermethylation of tumor suppressor genes in gastric cancer.

World Journal of Gastroenterology : WJG — Sat, 07 Jan 2012 05:00:00 +0100

CONCLUSION: Mosaic germline epimutation of the MLH1 gene is present in suspected hereditary GC patients in China but at a very low level. Germline epimutation of the CDH1 or P16(INK4a) gene is not a frequent event. PMID: 22228973 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Outcome after gastrectomy in gastric cancer patients with type 2 diabetes.

World Journal of Gastroenterology : WJG — Sat, 07 Jan 2012 05:00:00 +0100

CONCLUSION: The course of T2DM was significantly correlated to the BMI reduction ratio but not to the type of surgery without a significant change in BMI. PMID: 22228970 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma.

World Journal of Gastroenterology : WJG — Sat, 07 Jan 2012 05:00:00 +0100

CONCLUSION: Tregs are positively associated with endoscopic findings of gastroduodenal diseases and histological grade but negatively associated with intestinal metaplasia in gastritis and peptic ulcer groups. PMID: 22228968 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Histology classification challenges for the endoscopic treatment of early gastric cancer

Surgical Endoscopy — Fri, 06 Jan 2012 06:45:10 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00464-011-2134-yAuthors Christof Hottenrott, Chirurgische Klinik, St. Elisabethenkrankenhaus, Ginnheimer Straße 3, 60487 Frankfurt, Germany Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)

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Correlation Between the Pretherapeutic Neutrophil to Lymphocyte Ratio and the Pathologic Response to Neoadjuvant Chemotherapy in Patients With Advanced Esophageal Cancer

World Journal of Surgery — Fri, 06 Jan 2012 06:45:03 +0100

Conclusions Our study is the first to demonstrate that the pretherapeutic NLR can be used as a predictor for chemosensitivity of thoracic esophageal cancer. Preoperative evaluation based on the clinical N stage and NLR may be easily used in routine clinical practice. Content Type Journal ArticlePages 1-6DOI 10.1007/s00268-011-1411-1Authors Hiroshi Sato, Division of Esophageal Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777 JapanYasuhiro Tsubosa, Division of Esophageal Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777 JapanTatsuyuki Kawano, Department of Esophago-Gastric Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan Journal World...

EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population

Molecular Carcinogenesis — Fri, 06 Jan 2012 05:00:00 +0100

In this study, we conducted a genotyping analysis for EZH2 in 311 cases of gastric cancer and 425 controls from the Chinese Han population. We found five single nucleotide polymorphisms (SNP; rs12670401, rs6464926, rs2072407, rs734005, and rs734004) of EZH2 gene were significantly associated with the risk of gastric cancer. Of which, the rs12670401 with the minor allele C and rs6464926 with the minor allele T revealed strong associations with increased gastric cancer risk [P = 0.009, adjusted odds ratio (aOR) = 1.327, 95% CI = 1.075–1.683 and P = 0.012, aOR = 1.310, 95% CI = 1.059–1.619]. The other three SNPs, rs2072407, rs734005, and rs734004 contributed to significantly reduced risk of gastric cancer (P = 0.033, aOR = 0.787, 95% CI = 0.633–0.981,...

Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature

BMC Cancer — Fri, 06 Jan 2012 05:00:00 +0100

Conclusions: E-cadherin genetic screenings performed in low-risk areas for gastric cancer identified a higher frequency of CDH1 germline mutations. This data could open new approaches in the gastric cancer prevention test; before proposing a proband candidate for the CDH1 genetic screening, geographic variability, alongside the family history should be considered. (Source: BMC Cancer)

HER2 testing in gastric cancer: a practical approach

Modern Pathology AOP — Fri, 06 Jan 2012 05:00:00 +0100

Authors: Josef Rüschoff, Wedad Hanna, Michael Bilous, Manfred Hofmann, Robert Y Osamura, Frédérique Penault-Llorca, Marc van de Vijver & Giuseppe Viale (Source: Modern Pathology AOP)

Risk factors of early re-bleeding and mortality in patients with ruptured gastric varices and concomitant hepatocellular carcinoma

Journal of Gastroenterology — Thu, 05 Jan 2012 17:06:14 +0100

Conclusion Patients with GVB and concomitant HCC are associated with poor outcomes. Recently developed HCC, a high MELD score, active bleeding, advanced tumor stage, and elevated alanine transaminase are poor prognostic predictors. Apart from pharmacological and endoscopic treatments for GVB, careful investigation of a recently developed HCC in these patients is mandatory. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0518-3Authors Chen-Jung Chang, School of Medicine, National Yang Ming University, Taipei, TaiwanMing-Chih Hou, School of Medicine, National Yang Ming University, Taipei, TaiwanWei-Chih Liao, School of Medicine, National Yang Ming University, Taipei, TaiwanFa-Yauh Lee, School of Medicine, Nationa...

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The Use of AlbuMAX II® as a Blood or Serum Alternative for the Culture of Helicobacter pylori

Helicobacter — Thu, 05 Jan 2012 16:46:08 +0100

Conclusions: AlbuMAX II® (Gibco BRL) can be used as a serum/blood replacement for the cultivation of H. pylori in solid and liquid media. This medium could be useful for an improved understanding of H. pylori metabolism or for antigen production. Furthermore, AlbuMAX II® (Gibco BRL) may be suitable for use in remote locations, particularly in areas where frozen storage of serum may be a problem. (Source: Helicobacter)

Strong YB‐1 expression is associated with liver metastasis progression and predicts shorter disease‐free survival in advanced gastric cancer

Journal of Surgical Oncology — Wed, 04 Jan 2012 17:41:38 +0100

ConclusionsOur results indicate that YB‐1 plays a role in the process of GC metastasis, and that the immunohistochemical detection of this protein potentially delivers valuable insight regarding the prediction of liver metastasis and shorter DFS in patients undergoing curative resection for advanced GC. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

Gastric Cancer Development after Helicobacter pylori Eradication Therapy: A New Form of Gastric Neoplasia

Karger Publishers — Wed, 04 Jan 2012 17:15:25 +0100

Digestion 2012;85:61–67 (DOI:10.1159/000335260) (Source: Karger Publishers)

The founder Ashkenazi Jewish mutations in the MSH2 and MSH6 genes in Israeli patients with gastric and pancreatic cancer

Familial Cancer — Wed, 04 Jan 2012 17:03:09 +0100

Abstract The genetic basis for gastric and pancreatic cancer is largely undetermined. These cancers are overrepresented in hereditary non polyposis colon cancer (HNPCC), inherited cancer syndrome attributed to germline mutations primarily in the MSH2, MLH1 and MSH6 genes. Among Ashkenazi Jewish HNPCC cases, recurring mutations in the MSH2 (1906G>C; A636P) and MSH6 (c.3984_3987dupGTCA; c.3959_3962delCAAG) genes can be detected. The MSH6*c.3984_3987dupGTCA mutation was recently detected in an Ashkenazi family with inherited gastric cancer. We hypothesized that it may be possible to detect the recurring MSH2 and MSH6 mutations in Jewish individuals with familial and sporadic gastric and pancreatic cancer. To test this notion, we genotyped 143 unrelated Jewish Israeli patients...

Primary percutaneous coronary intervention and intravascular ultrasound imaging for coronary thrombosis after cisplatin-based chemotherapy

Heart and Vessels — Wed, 04 Jan 2012 16:59:49 +0100

Abstract Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cisplatin-based chemotherapy, has been limited. Case 1 with postoperative gastric cancer developed acute myocardial infarction (AMI) on the sixth day of the second chemotherapy course with conventional doses of cisplatin and tegafur gimeracil oteracil potassium. Emergency coronary angiography (CAG) showed a filling defect in the proximal left anterior descending coronary artery (LAD) concomitant with no reflow in the distal LAD. Case 2 with advanced lung c...

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Differences of the Lymphatic Distribution and Surgical Outcomes Between Remnant Gastric Cancers and Primary Proximal Gastric Cancers

Journal of Gastrointestinal Surgery — Wed, 04 Jan 2012 07:01:52 +0100

Conclusion Although the clinical behaviors of the two gastric cancers were different, the survival rates were similar. The pattern of metastasis indicates that the jejunal mesentery and splenic hilar lymph nodes should be specifically targeted for en bloc resection during complete gastrectomy in RGC. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s11605-011-1804-3Authors Shuhei Komatsu, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, JapanDaisuke Ichikawa, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, JapanKazuma Okamoto, Division of D...

S100A9, GIF and AAT as potential combinatorial biomarkers in gastric cancer diagnosis and prognosis

Proteomics. Clinical Applications — Wed, 04 Jan 2012 05:00:00 +0100

Conclusion and clinical relevanceEarly diagnosis, accurate staging and constant disease monitoring remain the pre‐requisites for effective treatment against GC. As current biomarkers like CA19‐9 and carcinoembryonic antigen (CEA) lack sensitivity and specificity, there is a pressing need for novel GC detection and monitoring methods. To this end, S100A9, GIF and AAT from the gastric fluid may significantly augment existing methods of GC detection and monitoring, and eliminate the need for invasive tissue biopsies. (Source: Proteomics. Clinical Applications)

Soy may not protect against stomach cancer

Reuters: Health — Tue, 03 Jan 2012 22:18:29 +0100

NEW YORK (Reuters Health) - Estrogen-like compounds that come with a soy-rich diet are sometimes linked to a reduced risk of cancer, but new research from Japan suggests that protection doesn't extend to stomach cancer. (Source: Reuters: Health)

Soy May Not Protect Against Stomach Cancer

MedlinePlus Health News — Tue, 03 Jan 2012 22:18:23 +0100

Estrogen-like compounds that come with a soy-rich diet are sometimes linked to a reduced risk of cancer, but new research from Japan suggests that protection doesn't extend to stomach cancer. Source: Reuters Health Related MedlinePlus Pages: Nutrition, Stomach Cancer (Source: MedlinePlus Health News)

MedWorm: Gastric (Stomach) Cancer

Six-Organ Transplant Girl Goes Home Today

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Crab-like robot sent down throat removes stomach cancer with delicate pincers

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Children’s becomes first hospital in New England to complete six organ transplant

9-Year-Old Girl Heading Home After 6 Organ Transplant At Children’s Hospital

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Inhibition of NF‐ κB Activity by Minor Polar Components of Extra‐Virgin Olive Oil at Gastric Level

Association of hOGG1 Ser326Cys polymorphism with gastric cancer risk: a meta-analysis.

Experts build crab-like robot to remove stomach cancer

Green Tea & Stomach Cancer

The association of statins and taxanes: an efficient combination trigger of cancer cell apoptosis

Serological Assessment of gastric mucosal Atrophy in gastric Cancer.

Ten cases of gastro‐tracheobronchial fistula: a serious complication after esophagectomy and reconstruction using posterior mediastinal gastric tube

Breast cancer biomarkers predict weight loss after gastric bypass surgery

Bowel cancer awareness campaign launched

GATA5 CpG island methylation in renal cell cancer: a potential biomarker for metastasis and disease progression

Superoxide dismutase activity of Helicobacter pylori per se from 158 clinical isolates and the characteristics

Phase II Trial of Preoperative Chemotherapy with Docetaxel, Cisplatin and S-1 for T4 Locally Advanced Gastric Cancer

Cancer Incidence and Incidence Rates in Japan in 2006: Based on Data from 15 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Analysis for the Combination Expression of CK20, FABP1 and MUC2 is Sensitive for the Prediction of Peritoneal Recurrence in Gastric Cancer

Trends in Stomach Cancer Mortality Rates in Japan, USA, UK, France and Korea Based on the WHO Mortality Database

Experts recommend genetic counseling for young sarcoma patients

APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression

Proteomic research progress in lymphatic metastases of cancers

[Comment] Adjuvant therapy for gastric cancer after D2 gastrectomy

[Articles] Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial

Cytokeratin Expression Profiling in Gastric Carcinoma: Clinicopathologic Significance and Comparison with Tumor-Associated Molecules

Low-Dose Docetaxel Combined with (−)-Epigallocatechin-3-Gallate Inhibits Angiogenesis and Tumor Growth in Nude Mice with Gastric Cancer Xenografts

Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates

Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer

To resect or not resect in metastatic gastric cancer: that is the question!

ABC screening for gastric cancer is not applicable in a Japanese population with high prevalence of atrophic gastritis

Irregular bowel movement in gastrectomized subjects: bowel habits, stool characteristics, fecal flora, and metabolites

WITHDRAWN: Extended versus limited lymph nodes dissection technique for adenocarcinoma of the stomach.

Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery

Adenocarcinoma in the jejunal pouch after proximal gastrectomy for early stage upper gastric cancer: report of a case

The relationship between tissue factor and cancer progression: insights from bench and bedside

A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer

Biomarkers for antitumor activity of bevacizumab in gastric cancer models

Extended Lymph Node Excision Feasible in Gastric Cancer

DNA methylation status of REIC/Dkk-3 gene in human malignancies

Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer.

Morbidity and Mortality Results From a Prospective Randomized Controlled Trial Comparing Billroth I and Roux-en-Y Reconstructive Procedures After Distal Gastrectomy for Gastric Cancer

Multivariable Analysis of Cholecystectomy after Gastrectomy: Laparoscopy is a Feasible Initial Approach even in the Presence of Common Bile Duct Stones or Acute Cholecystitis

MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4

Safe laparoscopic resection of a gastric gastrointestinal stromal tumor close to the esophagogastric junction

A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

External validation of nomogram for the prediction of recurrence after curative resection in early gastric cancer

Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers

Survival from common and rare cancers in Germany in the early 21st century

Dietary cholesterol intake and cancer

Gastric Ca Survival Rates Down, Chemo Use Up

The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7/20+ phenotype is more spesific than CDX2 antibody

Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms

Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer

Evaluation of apoptosis along with BCL-2 and Ki-67 expression in patients with intestinal metaplasia.

Tesetaxel shows efficacy against gastric cancer in study

Oral Taxane Shows Promise in Stomach Cancer

Drug No Help for Survival in Advanced Gastric Ca

[Pathology and classification of intraductal papillary mucinous neoplasms of the pancreas.]

Rapid high‐performance liquid chromatography method for determination of tryptophan in gastric juice

Future candidates for indications of Helicobacter pylori eradication: Do the indications need to be revised?

Magnetic nanoparticles for treatment of gastric cancer

Adverse Effects of GI Cancer Therapy Long-Lasting

GRANITE-1: Second-line everolimus did not extend OS for advanced gastric cancer

Free peritoneal tumor cells detection in gastric and colorectal cancer patients

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley

New Clinical Trial Confirms the Activity of Tesetaxel in Patients With Advanced Gastric Cancer

Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models

Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma

Activation of lytic cycle of Epstein‐Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma

Docetaxel and Cisplatin plus Fluorouracil compared with modified docetaxel, Cisplatin, and 5-Fluorouracil as first-line therapy for advanced gastric cancer: a retrospective analysis of single institution.

Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells.

Endoscopic Submucosal Dissection for Undifferentiated Early Gastric Cancer as the Expanded Indication Lesion

Esophageal Cancer May Be Caused By Migration Of Cancer-Causing Stomach Cells

Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas

Efficacy of weekly paclitaxel in patients with advanced gastric cancer refractory to docetaxel-based chemotherapy

Docetaxel and Cisplatin plus Fluorouracil compared with modified docetaxel, Cisplatin, and 5-Fluorouracil as first-line therapy for advanced gastric cancer: a retrospective analysis of single institution.

Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells.