MedWorm: Hodgkin's Disease

Burkitt lymphoma in UGANDA, the legacy of Denis Burkitt and an update on the disease status

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryBurkitt lymphoma (BL) was first described in Uganda in 1958 as a sarcoma of the jaw but later confirmed to be a distinct form of Non Hodgkin lymphoma (NHL). This discovery was the defining moment of cancer research in Uganda, which eventually led to the establishment of a dedicated cancer research institute, the Uganda Cancer Institute (UCI) in 1967. The centre was dedicated to Denis Burkitt in recognition of his contribution to cancer research in East Africa. BL is still the commonest NHL in childhood in Uganda. Its incidence has significantly increased recently due to yet unknown factors. Although the human immunodeficiency virus (HIV) was considered a possible reason for the increase, there is no evidence that it has substantially impacted on the epidemiology of the disease. Howe...

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Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. (Source: JNCI)

Burkitt lymphoma: staging and response evaluation

British Journal of Haematology — Wed, 01 Feb 2012 05:00:00 +0100

SummaryThe refinements in both the staging and response evaluation of children with Burkitt lymphoma (BL) have contributed to the improvements in treatment outcome observed over the past 40 years. Ziegler and Magrath designed a staging system in the 1970s for children with BL in equatorial Africa. Currently, the most widely used staging system around the world is that described by Murphy in 1980, which was developed for children with non‐Hodgkin lymphoma (NHL) of any histology. There are opportunities for refinement in this system, particularly with respect to certain extra‐nodal sites, such as skin and bone. The findings obtained at diagnosis with novel technologies (functional imaging [e.g., positron emission tomography [PET]] and minimal residual disease [MRD] technology), which ar...

Triple fungal infection in a patient with liver cirrhosis.

Annales de Biologie Clinique — Wed, 01 Feb 2012 05:00:00 +0100

We report a case of triple fungal infection including an invasive pulmonary aspergillosis by Aspergillus fumigatus, a candidemia by Candida albicans and a Pneumocystis pneumonia. The overall clinical picture of this patient was liver cirrhosis with medical history of immunosuppressive treatment for Crohn disease and a non-hodgkin lymphoma. There was no antifungal prophylaxis for this patient. Under treatment, the issue was unfavourable with multivisceral failure. PMID: 22294141 [PubMed - as supplied by publisher] (Source: Annales de Biologie Clinique)

High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults

NeLM - Disease Focused Reviews — Wed, 01 Feb 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Disease Focused Reviews Background Follicular lymphoma (FL) is the most common indolent and second most common Non-Hodgkin`s lymphoma (NHL) in the Western world. Standard treatment usually includes rituximab and chemotherapy. High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is an option for patients in advanced stages or for second-line therapy, leading to improved progression-free survival (PFS) rates. However, the impact of HDT and ASCT remains unclear, as there are hints of an increased risk of second cancers. Objectives We performed a systematic review with meta-analysis of randomised controlled trials (RCTs) comparing HDT plus ASCT with chemotherapy or immuno-chemotherapy in patien...

[Relationship between Castleman's disease and non-Hodgkin lymphoma.]

Anales de Pediatria — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Cantos Pastor V, Márquez Vega C, Ramírez Villar G, Espín Jaime B PMID: 22305085 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

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Central nervous system lymphoma occurring in a patient with neurofibromatosis type 1 (von Recklinghausen disease)

Neurological Sciences — Tue, 31 Jan 2012 16:44:48 +0100

We report a case of CNS primitive lymphoma in an adult patient who resulted positive for NF1 at genetic testing. At present, only one case of CNS lymphoma in an adult patient displaying clinical criteria for NF1 diagnosis has been reported. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s10072-011-0886-8Authors Marica Eoli, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, Unit of Molecular Neuro-Oncology, Milan, ItalyDonata Bianchessi, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyAnna Luisa Di Stefano, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyElena Prodi, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyElena Anghileri, Fondazione I.R.C.C.S. Istituto Neurologic...

Lymphoma Study Group of JCOG

Japanese Journal of Clinical Oncology — Mon, 30 Jan 2012 05:00:00 +0100

The Lymphoma Study Group (LSG) of the Japan Clinical Oncology Group (JCOG) was initiated in 1978 by five institutions and now has 47 members. JCOG-LSG has focused on combined modalities, dose intensification and the incorporation of new agents for major disease entities of lymphoid malignancies. More than 30 trials including 10 randomized trials have been conducted for aggressive non-Hodgkin's lymphoma (NHL), adult T-cell leukemia–lymphoma (ATL), lymphoblastic lymphoma/acute lymphoblastic leukemia, Hodgkin's lymphoma (HL), multiple myeloma, NK/T-NHL and indolent B-NHL, and correlative epidemiological and pathological studies have been performed on human T-lymphotropic virus type-I and T/B cell phenotypes. The first trials for aggressive NHL revealed significant differences in the pro...

The long‐term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study

Alimentary Pharmacology and Therapeutics — Mon, 30 Jan 2012 05:00:00 +0100

ConclusionsThe overall risk of malignancy in coeliac patients declines with time after diagnosis and is not significantly increased after 15 years. Most of the increased risk can be attributed to the development of haematological malignancies, despite their very low absolute rate of occurrence. (Source: Alimentary Pharmacology and Therapeutics)

Primary cutaneous CD30 positive T‐cell lymphoproliferative disorders with aberrant expression of PAX5: Report of three cases

Pathology International — Mon, 30 Jan 2012 05:00:00 +0100

This study is the first to address the clinical significance of PAX5+ primary cutaneous CD30+ T‐cell LPDs. These cases were distinct regarding PAX5 expression and a relatively aggressive clinical course versus conventional primary cutaneous CD30+ T‐cell LPDs. (Source: Pathology International)

CD163 Versus CD68 in Tumor Associated Macrophages of Classical Hodgkin Lymphoma

Diagnostic Pathology — Mon, 30 Jan 2012 05:00:00 +0100

In conclusion, we demonstrate that CD163 staining is lower than CD68, with less non-specific staining of background inflammatory cells and Hodgkin cells, therefore is a better marker for tumor associated macrophages. However, we did not identify a correlation between staining for CD68 or CD163 and recurrence of disease.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1460518258831620 (Source: Diagnostic Pathology)

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Advanced Stage, Increased Lactate Dehydrogenase, and Primary Site, but Not Adolescent Age (>= 15 Years), Are Associated With an Increased Risk of Treatment Failure in Children and Adolescents With Mature B-Cell Non-Hodgkin's Lymphoma: Results of the FAB LMB 96 Study [Hematologic Malignancies]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion LDH level at diagnosis, mediastinal disease, and combined BM-positive/CNS-positive involvement are independent risk factors in children with mature B-cell NHL. Future studies should be developed to identify specific therapeutic strategies (immunotherapy) to overcome these risk factors and to identify the biologic basis associated with these prognostic factors in children with mature B-cell NHL. (Source: Journal of Clinical Oncology)

[Oral Burkitt lymphoma in an immunocompetent patient.]

Archives de Pediatrie — Fri, 27 Jan 2012 05:00:00 +0100

We report a case of Burkitt lymphoma of the jaws in an immunocompetent adolescent, revealed by intraoral swelling. An orthopantomogram showed multiple osteolytic lesions. Biopsy revealed Burkitt lymphoma. The disease was treated with chemotherapy. Complete remission was attained 15 months after the end of treatment. Burkitt lymphomas accounts for 30-40% of all non-Hodgkin lymphomas in children, with diagnosis confirmed by histology. Immunophenotyping completes the diagnosis by identifying the presence of B markers. Chemotherapy is currently the main treatment of BL, because of the high chemosensitivity of the tumor and its low radiosensitivity. Overall survival in localized stages is close to 100%. PMID: 22285713 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Prevalence and patterns of renal involvement in imaging of malignant lymphoproliferative diseases.

Acta Radiologica — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionIn leukemia the most common imaging pattern is diffuse enlargement. In the other subtypes of lymphoproliferative disease no specific correlation between typical CT patterns and subtype of lymphoproliferative disease can be found. The prevalence of renal involvement is in line with earlier studies. Contrary to earlier reports, multiple lesions were not found to be a common pattern. PMID: 22287149 [PubMed - as supplied by publisher] (Source: Acta Radiologica)

Flow cytometric immunophenotypic assessment of T-cell clonality by vβ repertoire analysis in fine-needle aspirates and cerebrospinal fluid.

American Journal of Clinical Pathology — Thu, 26 Jan 2012 22:56:31 +0100

Authors: Tembhare P, Yuan CM, Morris JC, Janik JE, Filie AC, Stetler-Stevenson M Abstract Flow cytometric T-cell receptor V(β) repertoire analysis (TCR-V(β)-R) is a sensitive method to detect T-cell clonality; however, its implementation in low-cellularity specimens has not been established. We developed a strategy to use TCR-V(β)-R in cerebrospinal fluid (CSF) and fine-needle aspirate (FNA) specimens. Initially, full TCR-V(β)-R was evaluated in diagnostic/screening specimens from 8 patients with T-cell neoplasia to determine tumor-specific TCR-V(β) protein expression. Subsequently, an abbreviated, patient-specific TCR-V(β)-R evaluation was performed in 17 paucicellular specimens from the patients (8 CSF, 9 FNA) for staging and monitoring of minimal residual disease (MRD). A ...

Sarcoidosis: Challenging Diagnostic Aspects of an Old Disease

The American Journal of Medicine — Mon, 23 Jan 2012 23:44:59 +0100

In conclusion, we strongly advise that physicians be ready to reconsider the diagnosis of sarcoidosis in the presence of atypical manifestations or persistent/progressive disease despite conventional therapy. (Source: The American Journal of Medicine)

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Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease

Inflammatory Bowel Diseases — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions:Patients with IBD have an increased risk of developing PILD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases)

Tumour burden predicts treatment resistance in patients with early unfavourable or advanced stage Hodgkin lymphoma treated with ABVD and radiotherapy

Hematological Oncology — Mon, 23 Jan 2012 05:00:00 +0100

AbstractThe purpose of the work was to investigate the factors predicting early resistance to treatment in Hodgkin lymphoma. Many staging parameters, including relative tumour burden (rTB), were analysed in 246 patients with Hodgkin lymphoma in relation to early failure, that is, less than complete remission (i.e. partial response, null response or progression) or occurrence of early relapse, as clinical expressions of resistance to treatment. Patients with early unfavourable disease were 129 and were treated with four to six cycles of ABVD + involved field radiotherapy; 117 patients with advanced stage disease received six cycles of ABVD + optional irradiation to no more than two sites. The rTB was volumetrically measured through the evaluation of staging computed tomography for all the l...

Severe High-Density Lipoprotein Deficiency Associated With Autoantibodies Against Lecithin:Cholesterol Acyltransferase in Non-Hodgkin Lymphoma [Clinical Observation]

Archives of Internal Medicine — Mon, 23 Jan 2012 05:00:00 +0100

An antibody against the lecithin:cholesterol acyltransferase (LCAT) enzyme, which negates cholesterol esterification in plasma, causing severe high-density lipoprotein deficiency (HD), was identified in a woman with a large-cell non-Hodgkin lymphoma. Successful treatment of the lymphoma resulted in clearance of the antibody and complete correction of the defective cholesterol esterification and HD. To our knowledge, an acquired LCAT deficiency leading to severe HD has not been reported previously in association with a malignant disease, and this patient represents the first such documented case. (Source: Archives of Internal Medicine)

Brazilian experience using high dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation for malignant lymphomas

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSIONS: Despite a greater prevalence of poor prognostic factors, our results are comparable to the literature. The incidence of secondary neoplasias is noteworthy. Our study suggests that this approach is efficient and feasible, regardless of toxicity-related mortality (Source: Revista Brasileira de Hematologia e Hemoterapia)

Interim-treatment Quantitative PET Parameters Predict Progression and Death Among Patients with Hodgkin's Disease

Radiation Oncology — Thu, 19 Jan 2012 05:00:00 +0100

Conclusions: Calculated PET metrics may provide predictive information beyond that of traditional clinical factors and may identify patients at high risk of treatment failure early for treatment intensification. (Source: Radiation Oncology)

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Lymphomatoid papulosis: Clinical and pathological findings in 18 patients.

Actas Dermo-Sifiliograficas — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSION: LyP is typically a CD30(+) lymphoproliferative disorder that usually runs a benign course and responds well to treatment. PMID: 22261676 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Cancer Risk in Patients With Chronic Urticaria: A Population-Based Cohort Study [Evidence-Based Dermatology: Study]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

Conclusions Patients with chronic urticaria are at increased risk of cancer, especially hematologic malignant tumors. Further studies are needed to delineate the associations. (Source: Archives of Dermatology)

US FDA issues warning on brentuximab vedotin (Adcetris) and its association with progressive multifocal leukoencephalopathy

NeLM - News — Mon, 16 Jan 2012 05:00:00 +0100

Source: US FDA Area: News The US Food and Drug Administration (FDA) has issued an alert notifying healthcare professionals of 2 newly reported cases of progressive multifocal leukoencephalopathy (PML), associated with the use of brentuximab vedotin (Adcetris). The FDA has therefore also advised the manufacturer of the drug to include a boxed warning highlighting this risk, in addition to a contra-indication to the use of the drug in combination with bleomycin due to the increased risk of pulmonary toxicity. [The US FDA had approved brentuximab vedotin (Adcetris®) for the treatment of patients with Hodgkin lymphoma (HL) whose disease has progressed after autologous stem cell transplant or after two prior chemotherapy treatments for those who cannot receive a transpla...

A Novel Nanocarrier Delivery System for Doxorubicin With Improved Tumor Response and Reduced Systemic Toxicity in Advanced Pediatric Non-Hodgkin Lymphoma

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:59 +0100

Conclusions: Subcutaneous nanocarrier-delivery of doxorubicin demonstrated significantly improved tumor response with reduced systemic toxicity, confirmed via histology, compared to standard doxorubicin in an aggressive NHL model. This delivery platform allows lower doses of cytotoxic drugs to be administered and warrants further exploration for its clinical translation. (Source: Journal of Surgical Research)

Case report of hairy cell leukemia

Jornal Brasileiro de Patologia e Medicina Laboratorial — Sat, 14 Jan 2012 16:50:49 +0100

The objective of this study was to report the case of a male patient, tractor operator, diagnosed with HCL, pancytopenia, cutaneous lesions, without splenomegaly and positive markers for B-cell lymphocytes (CD19, CD20, CD22, CD79b, CD23, Lambda, immunoglobulin M [IgM], CD25 and CD103). Although HCL is a rare disease, late diagnosis may ultimately lead to severe complications and patient's death. (Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)

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Meta‐analysis: coeliac disease and the risk of all‐cause mortality, any malignancy and lymphoid malignancy

Alimentary Pharmacology and Therapeutics — Fri, 13 Jan 2012 05:00:00 +0100

ConclusionsPatients with coeliac disease are at an increased risk of mortality and non‐Hodgkin lymphoma, particularly T‐cell non‐Hodgkin lymphoma; they do not have an increased risk of any malignancy overall. Serologically defined patients with coeliac disease have an elevated risk of mortality and non‐Hodgkin lymphoma. (Source: Alimentary Pharmacology and Therapeutics)

Post Transplant Lymphoproliferative Disorders: Risk, Classification, and Therapeutic Recommendations

Current Treatment Options in Oncology — Thu, 12 Jan 2012 16:47:55 +0100

Opinion statement Post transplant lymphoproliferative disorder (PTLD) is a heterogeneous disease that may occur in recipients of solid organ transplants (SOT) and hematopoietic stem cell transplant. The risk of lymphoma is increased 20–120% compared with the general population with risk dependent in part on level of immune suppression. In addition, recent data have emerged, including HLA and cytokine gene polymorphisms, regarding genetic susceptibility to PTLD. Based on morphologic, immunophenotypic, and molecular criteria, PLTD are classified into 4 pathologic categories: early lesions, polymorphic, monomorphic, and classical Hodgkin lymphoma. Evaluation by expert hematopathology is critical in establishing the diagnosis. The aim of therapy for most patients is cure wit...

ABVD as the Treatment Option in Advanced Hodgkin's Lymphoma Patients Older than 45 Years.

Pathology Oncology Research — Wed, 11 Jan 2012 05:00:00 +0100

Authors: Andjelic BM, Mihaljevic BS, Jakovic LR Abstract Advanced age is considered an unfavourable prognostic factor for Hodgkin's lymphoma (HL). The optimal treatment for these patients is not yet defined, especially for the advanced stages. We analysed the outcome and prognostic relevance of patient and disease characteristics in 46 advanced stage HL patients who were older than 45 years, treated with ABVD. Elderly patients (>60 year) had a significantly higher rate of comorbidities (p < 0.05). The complete remission rate was significantly lower in elderly patients and in patients with an IPS ≥3 (p < 0.05, p < 0.05, respectively). Elderly patients had significantly shorter event-free survival (p < 0.01) and overall survival (p < 0.01) co...

Malignant melanoma as second malignant neoplasm in long‐term childhood cancer survivors: A systematic review

Pediatric Blood and Cancer — Mon, 09 Jan 2012 05:00:00 +0100

AbstractThis systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti‐mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Early relapse and refractory disease remain risk factors in the anthracycline and autologous transplant era for patients with relapsed/refractory classical Hodgkin lymphoma: a single centre intention‐to‐treat analysis

British Journal of Haematology — Mon, 09 Jan 2012 05:00:00 +0100

SummaryAn intention‐to‐treat (ITT) analysis was performed in 103 unselected patients with relapsed/refractory classical Hodgkin lymphoma (CHL) comparing early relapse (<12 months) or failure of first‐line therapy (ER/FTF) with late relapses (LR). Seventy one percentage proceeded to high‐dose therapy/autologous stem cell rescue (HDT/ASCR) following salvage treatment. By ITT, 5‐year overall survival (OS) was 50% for ER/FTF compared to 73% for LR patients (P = 0·012). However OS was equivalent for both groups if salvage treatment response was adequate to proceed to HDT/ASCR. ER/FTF patients remain a high‐risk group largely due to a failure of salvage therapy: a point at which novel interventions could impact survival. (Source: British Journal of Haematology)

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Plasma dioxin levels and cause-specific mortality in an occupational cohort of workers exposed to chlorophenoxy herbicides, chlorophenols and contaminants

Occupational and Environmental Medicine — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions Modelled TCDD exposure does not explain the previously reported increased risks for cancer mortality in this cohort except for a possible association with NHL. A small increase in ischaemic heart disease was observed, however we cannot exclude that this finding was due to residual confounding. Although risk estimates for some of the rarer outcomes were still rather imprecise, we do not expect more precise estimates from longer follow-up of this cohort due to the long time-span since last exposure to TCDD. (Source: Occupational and Environmental Medicine)

[Involved-node radiotherapy combined with deep-inspiration breath-hold technique in patients with Hodgkin lymphoma.]

Cancer Radiotherapie — Fri, 06 Jan 2012 05:00:00 +0100

CONCLUSIONS: Our results suggest that patients with localized Hodgkin lymphoma can be safely and efficiently treated using deep-inspiration breath technique and the involved-node radiotherapy concept. Longer follow-up is needed to assess late toxicity, especially for the heart and the coronary arteries. PMID: 22227468 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)

Clinical utility of 18F FDG-PET/CT in the detection of bone marrow disease in Hodgkin's lymphoma.

The British Journal of Radiology — Tue, 03 Jan 2012 05:00:00 +0100

Conclusion: (18)F-FDG-PET/CT and BMB are complementary in the evaluation of bone marrow disease. PMID: 22215887 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)

Intraosseous Fibrosarcoma of Maxilla in an HIV Patient.

Archives of Iranian Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Kotrashetti VS, Kale AD, Hallikeremath SR, Mane DR, V Angadi P, Bhatt P Abstract Fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. Fibrosarcomas account for 15% of all soft tissue sarcomas, which represent only 1% of all malignant tumors of the head and neck region. The clinical behavior of the fibrosarcoma is characterized by a high local recurrence rate, and low incidence of loco regional lymph node and/or distant hematogenous metastasis. The etiology for fibrosarcoma has no definite cause but is thought to occur from preexisting lesions or in previously irradiated areas of bone lesions. Immunosuppression associated with HIV infection and acquired immune deficiency syndrome (...

[Acquired ichthyosis and haematological malignancies: Five cases].

Annales de Dermatologie et de Cenereologie — Sun, 01 Jan 2012 05:00:00 +0100

CONCLUSION: Acquired ichthyosis should prompt the clinician to search for a neoplastic condition, primarily a haematological disorder, guided by other associated signs, given that in our study, skin lesions generally appear to precede signs of the blood disease. PMID: 22225737 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

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Hodgkin lymphoma of the maxillary sinus: An unusual occurrence.

Ear, Nose and Throat Journal — Sun, 01 Jan 2012 05:00:00 +0100

We report the case of a 60-year-old woman who presented with nasal congestion and obstruction. Examination revealed an abnormal-appearing mucosa involving the maxillary sinus. Subsequent evaluation led to a diagnosis of Hodgkin lymphoma. Because making such a diagnosis is difficult, close attention to radiologic and pathologic findings is important. Our review of the literature revealed that treatment commonly includes chemotherapy and radiotherapy, which yield excellent outcomes. The current standard of care for patients with similar-stage Hodgkin lymphoma at other sites can guide the treatment course for patients with extranodal Hodgkin lymphoma. PMID: 22278873 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Current Status of Autologous Stem Cell Transplantation in Relapsed and Refractory Hodgkin's Lymphoma.

The Oncologist — Fri, 30 Dec 2011 05:00:00 +0100

We present a summary of developments in each of these areas. PMID: 22210089 [PubMed - as supplied by publisher] (Source: The Oncologist)

PET/CT surveillance in patients with Hodgkin lymphoma in first remission is associated with low positive predictive value and high costs.

Haematologica — Thu, 29 Dec 2011 05:00:00 +0100

Conclusions. A negative PET/CT reliably rules out a relapse. The high false positive rate, however, is an important limitation and a confirmatory biopsy is mandatory for the diagnosis of a relapse. With no proven survival benefit for patients with a pre-clinically diagnosed relapse, the high costs and low positive predictive value make PET/CT unfit for routine surveillance of Hodgkin lymphoma patients. PMID: 22207683 [PubMed - as supplied by publisher] (Source: Haematologica)

Treatment of B cell lymphoma with chemotherapy plus rituximab: a survival benefit can be demonstrated in the routine data of a regional cancer registry

Annals of Hematology — Tue, 27 Dec 2011 06:33:55 +0100

Abstract Combination of standard chemotherapy with rituximab led to improved disease control in patients with B cell lymphoma in clinical trials. We wanted to know if a similar benefit could be demonstrated in the routine data of a regional population-based cancer registry. We searched the registry of the Regensburg Tumor Center for B cell non-Hodgkin lymphomas diagnosed between 1998 and 2006 and compared overall survival of patients receiving any first-line chemotherapy with or without rituximab. Comparing registry data to death certificates, an 86% coverage within the registry was estimated. In the aggressive lymphoma group, 133 patients received rituximab-containing chemotherapy resulting in a 5-year survival of 69.6%, whereas 205 patients received chemotherapy alone wi...

Potential of post-chemotherapy follow-up in lymphoma patients using dose minimization technique with [18F]FDG-PET/CT.

Cancer Imaging — Mon, 26 Dec 2011 17:24:03 +0100

Conclusion: Limiting PET/CT to sites of known disease would have resulted in a mean radiation dose saving of 4 mSv (27.3%), with a mean time saving of 16 min per PET/CT. Our study suggests young lymphoma patients may benefit from reduced radiation dose/scan time by limiting PET/CT to sites of known disease with low risk of missing significant pathology. However, in older patients, with increased incidence of asymptomatic synchronous malignancies, we recommend whole-body PET/CT is advisable unless pre-chemotherapy PET/CT has been performed. PMID: 22186113 [PubMed - in process] (Source: Cancer Imaging)

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4. FDG-PET/CT of extranodal involvement in paediatric Hodgkin lymphoma.

Cancer Imaging — Mon, 26 Dec 2011 17:24:03 +0100

Conclusion: Our study reiterates that FDG-PET/CT helps in identifying extranodal HL, particularly in the skeleton and liver. CT is advantageous in characterizing lung findings. PMID: 22186086 [PubMed - in process] (Source: Cancer Imaging)

SUV‐measurements and patient‐specific corrections thereof in pediatric Hodgkin‐lymphoma: Is there a benefit for PPV in early response assessment by FDG‐PET?

Pediatric Blood and Cancer — Thu, 22 Dec 2011 01:30:23 +0100

ConclusionsAt early response assessment by FDG‐PET, patient‐specific correction of ΔSUVmax by BSA improves PPV without impairment of excellent NPV in pHL. However, it is not statistically superior to simple ΔSUVmax‐analyses. Larger cohorts are needed to investigate this observation. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

High prevalence of hepatitis B virus infection in HIV-negative Castleman's disease

Annals of Hematology — Wed, 21 Dec 2011 19:46:41 +0100

In conclusion, our findings suggest an association between HBV infection and development of CD. CD patients with HBV infection have their own distinguished features. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00277-011-1388-8Authors Xiang-Gui Yuan, The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University; Department of Internal Medicine, Hangzhou Binjiang Hospital, Hangzhou, China 310009Fei-Fei Chen, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, China 310003Yi-Miao Zhu, The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University; Department of Internal Medicine, Hangzhou Binjiang Hospital, Hangzhou, China 310...

PET technique promises better detection and response assessment for Non-Hodgkin's lymphoma

EurekAlert! - Medicine and Health — Wed, 21 Dec 2011 05:00:00 +0100

(Society of Nuclear Medicine) Positron emission tomography and a molecular imaging agent that captures the proliferation of cancer cells could prove to be a valuable method for imaging a form of Non-Hodgkin's disease called mantle cell lymphoma, a relatively rare and devastating blood cancer. (Source: EurekAlert! - Medicine and Health)

[Breast cancer after Hodgkin disease.]

Gynecologie, Obstetrique et Fertilite — Tue, 20 Dec 2011 05:00:00 +0100

We report a case of bilateral intraductal and invasive carcinoma that occurred 16 years after treatments for HD, developing its particularities in diagnosis and treatment, particularly place of conservative treatments and sentinel lymph node biopsy. PMID: 22192693 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

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Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation

Fertility and Sterility — Mon, 19 Dec 2011 05:00:00 +0100

Conclusion(s): Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank. (Source: Fertility and Sterility)

Second line salvage chemotherapy for transplant-eligible patients with Hodgkin lymphoma resistant to platinum-containing first-line salvage chemotherapy.

Haematologica — Fri, 16 Dec 2011 05:00:00 +0100

ConclusionPatients who require a second salvage regimen to achieve disease control prior to autologous stem cell transplantation have a relatively poor outcome and should be considered for alternative treatment strategies. PMID: 22180434 [PubMed - as supplied by publisher] (Source: Haematologica)

Long-term follow-up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning.

Haematologica — Fri, 16 Dec 2011 05:00:00 +0100

Conclusions. Cyclophosphamide and antithymocyte globulin is an effective conditioning regimen for patients with severe aplastic anemia and is associated with low treatment-related mortality. Long-term complications include avascular necrosis and endocrine dysfunction.Key words: Hematopoietic stem cell transplantation, severe aplastic anemia, long-term outcomes. PMID: 22180425 [PubMed - as supplied by publisher] (Source: Haematologica)

Sun exposure may increase risk of prostate cancer in the high UV environment of New South Wales, Australia: A case‐control study

International Journal of Cancer — Thu, 15 Dec 2011 05:00:00 +0100

AbstractUltraviolet radiation in sunlight may influence risk of prostate cancer. In New South Wales (NSW), Australia, we examined the relationship between sun exposure at 30 and 50 years of age and risk of prostate cancer in a case‐control study combining the NSW Prostate Cancer Care and Outcome Study (cases) and the NSW Non‐Hodgkin Lymphoma Study (controls). Prostate cancer risk increased with increasing estimated sun exposure (adjusted OR for highest vs. lowest quartiles of average weekly sun exposure in the warmer months 2.07 95% CI: 1.36‐3.15) and this increase was most evident with weekend sun exposure (adjusted OR=5.55, 95%CI: 2.94‐10.48). High sun sensitivity was also positively associated with risk for prostate cancer (adjusted OR=1.63, 95% CI: 1.09‐2.44). The apparent ef...

Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications.

Pathology, Research and Practice — Thu, 15 Dec 2011 05:00:00 +0100

Authors: Kren L, Fabian P, Slaby O, Janikova A, Soucek O, Sterba J, Krenova Z, Michalek J, Kral Z Abstract Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or backround microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells a...

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Sun exposure may increase risk of prostate cancer in the high UV environment of New South Wales, Australia: A case–control study

International Journal of Cancer — Thu, 15 Dec 2011 05:00:00 +0100

AbstractUltraviolet (UV) radiation in sunlight may influence risk of prostate cancer. In New South Wales (NSW), Australia, we examined the relationship between sun exposure at 30 and 50 years of age and risk of prostate cancer in a case–control study combining the NSW prostate cancer care and outcome study (cases) and the NSW non‐Hodgkin's lymphoma study (controls). Prostate cancer risk increased with increasing estimated sun exposure (adjusted OR for highest vs. lowest quartiles of average weekly sun exposure in the warmer months 2.07 95% CI: 1.36–3.15) and this increase was most evident with weekend sun exposure (adjusted OR = 5.55, 95% CI: 2.94–10.48). High sun sensitivity was also positively associated with risk for prostate cancer (adjusted OR = 1.63, 95% CI: 1.09–2.44). The...

Increasing incidence of enteropathy‐associated T‐cell lymphoma in the United States, 1973‐2008

Cancer — Tue, 13 Dec 2011 05:00:00 +0100

CONCLUSIONS:The current results indicated a significant increase in the incidence of EATL in the United States, which may reflect the increasing seroprevalence of CD and better recognition of rare types of T‐cell lymphomas. The incidence may continue to rise given the large ratio of undiagnosed‐to‐diagnosed individuals with CD in the United States. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

Long-term data suggests ABVD alone better than radiation-based therapy for limited-stage Hodgkin's lymphoma

NeLM - News — Mon, 12 Dec 2011 05:00:00 +0100

Source: New England Journal of Medicine Area: News According to research published early online in the New England Journal of Medicine (NEJM), the use of ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) chemotherapy alone for limited-stage Hodgkin's lymphoma is associated with lower 12-year mortality than those treated with a radiotherapy-based treatment, mainly due to fewer deaths from other causes. The authors note that the standard treatment for patients with low-risk stage IA or IIA non-bulky Hodgkin's lymphoma is the combination of two cycles of ABVD chemotherapy and radiotherapy. There was interest raised in the role of chemotherapy alone in these patients and a study was initiated in 1994 (Hodgkin's Disease.6 [HD.6]) to compare chemotherapy alone to...

Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma

EurekAlert! - Medicine and Health — Sun, 11 Dec 2011 05:00:00 +0100

(American Society of Hematology) Asymptomatic patients diagnosed with non-bulky follicular lymphoma, a slow-growing type of non-Hodgkin lymphoma, have traditionally been watched for signs or symptoms of disease progression and then treated with a combination of rituximab and chemotherapy or rituximab alone for select cases. Recent trials have suggested a role for treatment of asymptomatic patients with single-agent rituximab followed by additional periodic dosing, called "maintenance therapy." However, new research suggests that these patients may have similar success rates simply with as-needed treatment. (Source: EurekAlert! - Medicine and Health)

The Four Types of Tregs in Malignant Lymphomas

Journal of Hematology and Oncology — Fri, 09 Dec 2011 05:00:00 +0100

Regulatory T cells (Tregs) are a specialized subpopulation of CD4+ T cells, which act to suppress the activation of other immune cells. Tregs represent important modulators for the interaction between lymphomas and host microenvironment. Lymphomas are a group of serious and frequently fatal malignant diseases of lymphocytes. Recent studies revealed that some lymphoma T cells might adopt a Treg profile. Assessment of Treg phenotypes and genotypes in patients may offer prediction of outcome in many types of lymphomas including diffuse large B-cell lymphoma, follicular lymphoma, cutaneous T cell lymphoma, and Hodgkin's lymphoma. Based on characterized roles of Tregs in lymphomas, we can categorize the various roles into four groups: (a) suppressor Tregs; (b) malignant Tregs; (c) direct tumor-...

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Intravascular large B-cell lymphoma: report of three cases and analysis of the mTOR pathway.

International Journal of Clinical and Experimental Pathology — Thu, 08 Dec 2011 17:54:02 +0100

Authors: Shen Q, Duan X, Feng W, Nguyen N, Lapus A, Brown RE, Chen L Abstract Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive and often fatal non-Hodgkin lymphoma characterized by preferential growth of malignant B-cells within the lumina of small vessels. Rituximab plus anthracy-cline-based chemotherapy is the current standard regimen for IVLBCL, however it has minimal efficacy in relapsed or refractory diseases. Recent clinical trials have shown a significant anti-lymphoma activity of mammalian target of rapamycin (mTOR) inhibitors in relapsed and refractory diffuse large B-cell lymphoma (DLBCL); however, the activation status of the mTOR pathway and the therapeutic potential of mTOR inhibitors in IVLBCL have not yet been studied. Here we described the clinicop...

Phase 2 study of PVAG (prednisone, vinblastine, doxorubicin, gemcitabine) in elderly patients with early unfavorable or advanced stage Hodgkin lymphoma

Blood — Thu, 08 Dec 2011 05:00:00 +0100

Approximately 20% of all Hodgkin lymphoma (HL) patients are older than 60 years and have a poor prognosis, mainly because of increased treatment-related toxicity resulting in reduced overall dose intensity and more treatment-related mortality. To possibly improve the treatment of elderly HL patients, the German Hodgkin Study Group developed a new regimen, PVAG (prednisone, vinblastine, doxorubicin, and gemcitabine). In this multicenter phase 2 study, elderly HL patients in early unfavorable and advanced stages received 6 to 8 cycles of PVAG and additional radiotherapy if they were not in complete remission (CR) after chemotherapy. Endpoints included feasibility, acute toxicity, and response rate. Fifty-nine patients 60 to 75 years of age (median, 68 years) were eligible for analysis; 93% h...

Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection

Infectious Diseases in Obstetrics and Gynecology — Wed, 07 Dec 2011 16:10:27 +0100

We report a case of localized MALT lymphoma of the lacrimal gland, with prolonged sustained remission after eradication of gastric Helicobacter pylori (H. Pylori) infection. He sustains in remission of lacrimal MALT lymphoma for four years without chemotherapy or radiotherapy. (Source: Infectious Diseases in Obstetrics and Gynecology)

The role of prophylactic antimicrobials during autologous stem cell transplantation: a single-center experience

European Journal of Clinical Microbiology and Infectious Diseases — Sat, 03 Dec 2011 06:48:59 +0100

Abstract The aim of this study was to investigate the efficacy of antibiotic prophylaxis in patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma and non-Hodgkin lymphoma. Among 232 ASCT cases performed at the Asan Medical Center, 114 cases underwent treatment with ciprofloxacin, fluconazole, and acyclovir (between January 2001 and August 2005), while 118 cases were performed without antimicrobial prophylaxis (between February 2004 and June 2008). The two-rate χ2 test was applied to accommodate the differences in neutropenia duration. The incidence of febrile episodes was 9.8 cases per 100 person-days in the prophylactic group, while it was 16.2 cases in the no-prophylactic group (p < 0.001). The rate of unexplained fever was 8.0 cases ...

Temporal and geographic variations of Waldenstrom macroglobulinemia incidence

Cancer — Fri, 02 Dec 2011 05:00:00 +0100

CONCLUSIONS:Although the overall incidence of WM remained steady over time, significant increases in incidence were seen over the past 20 years in whites, in those aged 70 to 79 years, and in 3 geographic registry areas. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

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Hodgkin's disease revealed by a nephrotic syndrome: a case report with literature review.

Annales de Biologie Clinique — Thu, 01 Dec 2011 05:00:00 +0100

We report a case of Hodgkin's lymphoma in a young female patient with nephrotic syndrome. A 40-year-old woman presented with the clinical symptoms of nephrotic syndrome, kidney biopsy revealed minimal change glomerulonephritis. A treatment with prednisone was started but the response was partial. Twenty-four months after the diagnostic of nephrotic syndrome was made, she presented prolonged fever and weight loss, the physical examination showed cervical lymphadenopathy, which lymph node biopsy revealed Hodgkin lymphoma of the nodular sclerosing type. The patient was treated for Hodgkin disease stage IVB with ABVD regimen, and was in complete remission of both Hodgkin's disease and nephrotic syndrome. PMID: 22123569 [PubMed - as supplied by publisher] (Source: Annales de Biologie Cliniq...

[Intensity-modulated radiotherapy and involved-node concept in patients with Hodgkin lymphoma: Experience of the Gustave-Roussy Institute].

Cancer Radiotherapie — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSION: Our results suggest that patients with localized Hodgkin lymphoma can be safely and efficiently treated using the involved node irradiation concept and intensity modulated irradiation. PMID: 22116023 [PubMed - in process] (Source: Cancer Radiotherapie)

Real‐time PCR‐based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia

Hematological Oncology — Thu, 01 Dec 2011 05:00:00 +0100

AbstractHairy cell leukaemia (HCL) is a rare type of B‐cell non‐Hodgkin lymphoma (B‐NHL), which is not known to be associated with any characteristic recurrent karyotypic abnormality. A recent study that used massively parallel whole exome sequencing identified an activating V600E mutation in BRAF, which appeared specific for HCL. Here, we confirm the specificity of BRAF V600E for HCL among low and intermediate grade B‐NHL and describe a real‐time polymerase chain reaction method for detecting this mutation in cases with low tumour burden. The V600E mutation does not appear to be associated with microsatellite instability, unlike the case in colorectal cancer. Thus, in conjunction with prior data, our results suggest incorporation of BRAF V600E mutation analysis in the diagnostic...

Double‐delayed intensification paediatric protocol without radiotherapy is an efficient treatment in adult lymphoblastic lymphoma

Hematological Oncology — Thu, 01 Dec 2011 05:00:00 +0100

We report here the feasibility of a double‐delayed intensification paediatric protocol in 12 adult LBL patients. There were no relapses and no deaths, with a median follow‐up of 4.7 years. Using the same protocol, overall survival was significantly longer in LBL patients versus ALL patients (100% vs 75%, p = 0.05). Overall tolerance was acceptable and better in ALL patients. We have shown the feasibility and the good results of using this paediatric protocol in LBL. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Hematological Oncology)

Danvers Mother, Infant Daughter Struggle With Heartbreaking Cancer Fight

Thu, 01 Dec 2011 04:59:33 +0100

DANVERS (CBS) - 2011 hasn’t been kind to Mike and Kezia Fitzgerald. In January, Kezia was diagnosed with stage 3 Hodgkin’s Lymphoma. Less than 4 months later, a bigger shock rocked the family when their 11-month-old daughter, Saoirse, was diagnosed with Stage 4, nMYC amplified, Neuroblastoma. Summer brought a glimmer of hope for the Fitzgeralds. Kezia responded well to her cancer treatment and was in remission by the beginning of September. WBZ NewsRadio 1030′s Mark Katic reports Saoirse turned one in June and by September had completed her first six rounds of chemotherapy. Her body was re-scanned and the doctors at Children’s Hospital Boston declared her cancer free. Through it all, Saoirse dealt with her treatment as any toddler would, oblivious to the gravity and hap...

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Care of the Adult Hodgkin Lymphoma Survivor

The American Journal of Medicine — Fri, 25 Nov 2011 12:06:30 +0100

Abstract: Of those individuals diagnosed with Hodgkin lymphoma, 85% will survive and may be affected by residual effects of their cancer and its therapy (chemotherapy, radiation therapy, stem cell transplantation). Hodgkin lymphoma survivors are at risk of developing secondary malignancies, cardiovascular disease, pulmonary disease, thyroid disease, infertility, premature menopause, chronic fatigue, and psychosocial issues. These conditions usually have a long latency and therefore present years or decades after Hodgkin lymphoma treatment, when the patient's care is being managed by a primary care provider. This review summarizes these unique potential medical and psychologic sequelae of Hodgkin lymphoma, and provides screening and management recommendations. (Source: The American Journal ...

Mobilization and Harvesting of Peripheral Blood Stem Cells in Pediatric Patients With Solid Tumors

Therapeutic Apheresis and Dialysis — Fri, 25 Nov 2011 10:28:36 +0100

In conclusion, the collection of peripheral blood stem cells is an effective and safe procedure, even when conducted on the youngest children. (Source: Therapeutic Apheresis and Dialysis)

Polymorphisms in immune function genes and non-Hodgkin lymphoma survival

Journal of Cancer Survivorship — Wed, 23 Nov 2011 17:44:41 +0100

Conclusion Our study provides evidence that the identification of genetic polymorphisms in cytokine genes may help improve the prediction of NHL survival and prognosis. Content Type Journal ArticlePages 1-13DOI 10.1007/s11764-010-0164-4Authors Briseis Aschebrook-Kilfoy, School of Public Health, Yale University, New Haven, CT, USATongzhang Zheng, School of Public Health, Yale University, New Haven, CT, USAFrancine Foss, Department of Medical Oncology, Yale University School of Medicine, New Haven, CT, USAShuangge Ma, School of Public Health, Yale University, New Haven, CT, USAXuesong Han, School of Public Health, Yale University, New Haven, CT, USAQing Lan, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Departme...

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Sorafenib, a multi‐kinase inhibitor, is effective in vitro against non hodgkin lymphoma and synergizes with the mTOR inhibitor rapamycin

American Journal of Hematology — Wed, 23 Nov 2011 05:00:00 +0100

AbstractNon‐Hodgkin lymphoma (NHL) represents a heterogenous group of neoplasias originating from lymphoid cells. Increased angiogenesis and expression of Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFR) have been found to be associated with NHL disease progression. Increase in VEGF and other cytokines stimulate signaling cascades including the Ras/Raf/Mek/Erk pathway resulting in increased proliferation and decreased apoptosis. Here, we report the in vitro anti‐lymphoma activity of sorafenib, an inhibitor of VEGFR and Raf kinase. Sorafenib induced potent cytotoxicity in NHL cell lines and patient samples. This induction of cytotoxicity was associated with a corresponding increase in apoptotic cell death. Mechanism of action of sorafenib was investigated in follicula...

Sorafenib, a multikinase inhibitor, is effective in vitro against non‐hodgkin lymphoma and synergizes with the mTOR inhibitor rapamycin

American Journal of Hematology — Wed, 23 Nov 2011 05:00:00 +0100

AbstractNon‐Hodgkin lymphoma (NHL) represents a heterogenous group of neoplasias originating from lymphoid cells. Increased angiogenesis and expression of Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFR) have been found to be associated with NHL disease progression. Increase in VEGF and other cytokines stimulate signaling cascades, including the Ras/Raf/Mek/Erk pathway, resulting in increased proliferation and decreased apoptosis. Here, we report the in vitro antilymphoma activity of sorafenib, an inhibitor of VEGFR and Raf kinase. Sorafenib induced potent cytotoxicity in NHL cell lines and patient samples. This induction of cytotoxicity was associated with a corresponding increase in apoptotic cell death. Mechanism of action of sorafenib was investigated in follicular...

Acute or Chronic Life-Threatening Diseases Associated With Epstein-Barr Virus Infection.

The American Journal of the Medical Sciences — Thu, 17 Nov 2011 05:00:00 +0100

Authors: Okano M, Gross TG Abstract Infectious mononucleosis (IM) is one of the representative, usually benign, acute diseases associated with primary Epstein-Barr virus (EBV) infection. IM is generally self-limiting and is characterized mostly by transient fever, lymphadenopathy and hepatosplenomegaly. However, very rarely primary EBV infection results in severe or fatal conditions such as hemophagocytic lymphohistiocytosis together with fulminant hepatitis designated as severe or fatal IM or EBV-associated hemophagocytic lymphohistiocytosis alone. In addition, chronic EBV-associated diseases include Burkitt's lymphoma, undifferentiated nasopharyngeal carcinoma, Hodgkin lymphoma, T-cell lymphoproliferative disorder (LPD)/lymphoma, natural killer-cell LPD including leukemia or lymp...

Gemcitabine-associated Sweet syndrome–like eruption

Journal of the American Academy of Dermatology — Wed, 16 Nov 2011 21:07:47 +0100

We report a patient with non-Hodgkin lymphoma who developed a pseudovesiculous skin rash following gemcitabine therapy. (Source: Journal of the American Academy of Dermatology)

Early-Stage Hodgkin Disease in a 24-Year-Old Woman

Seminars in Oncology — Wed, 16 Nov 2011 17:05:34 +0100

At times we encounter clinical problems for which there are no directly applicable evidence-based solutions, but we are compelled by circumstances to act. When doing so we rely on related evidence, general principles of best medical practice, and our experience. Each “Current Clinical Practice” feature article in Seminars in Oncology describes such a challenging presentation and offers treatment approaches from selected specialists. We invite readers' comments and questions, which, with your approval, will be published in subsequent issues of the Journal. It is hoped that sharing our views and experiences will better inform our management decisions when we next encounter similar challenging patients. Please send your comments on the articles, your challenging cases, and your treatment ...

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[Hodgkin's disease and breast cancer: For which patients is there an association? A series from Institut Bergonié]

Gynecologie, Obstetrique et Fertilite — Wed, 16 Nov 2011 05:00:00 +0100

CONCLUSION: This population of women with a high risk of breast cancer thus has to benefit from an appropriate monitoring program, which is what we suggest setting up in the Institut Bergonié. PMID: 22099978 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

Did Jane Austen die of arsenic poisoning?

The Poison Review — Tue, 15 Nov 2011 04:09:52 +0100

Jane Austen The novelist Jane Austen (1775-1817) died at the early age of 41, after a chronic illness that caused progressive deterioration over a year or more. Although the cause of death has not been definitely established, previous literary historians have speculated about a wide range of diagnoses, including Addison’s Disease, lupus, Hodgkin’s lymphoma, tuberculosis, and Brill-Zinsser disease (re-activated typhus). As The Guardian (U.K.) reports today, mystery writer Lindsay Ashford has recently suggested another possibility: arsenic toxicity. While researching a new book, Ashford noted a sentence in a letter Austen wrote several months before she died: I am considerably better now and am recovering my looks a little, which have been bad enough, black and white and ever...

T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification

Virchows Archiv — Fri, 11 Nov 2011 12:49:20 +0100

Abstract T cell/histiocyte-rich large B-cell lymphoma (THRLBCL), originally considered an uncommon variant of Diffuse Large B-Cell Lymphoma (DLBCL), is recognized by the World Health Organisation as a separate clinicopathological entity since 2008. It predominantly affects middle aged men often presenting with advanced stage disease frequently involving spleen, liver and bone marrow at time of diagnosis. According to the WHO, this lymphoma is morphologically characterized by less than 10% of large neoplastic B cells in a background of abundant T cells and frequently histiocytes. Differentiating THRLBCL from other lymphoproliferative disorders such as Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) and Lymphocyte-Rich classical Hodgkin lymphoma (LRcHL) is important ...

Pulmonary lymphoma: computed tomography features with pathologic correlation

The Chinese-German Journal of Clinical Oncology — Fri, 11 Nov 2011 06:53:26 +0100

Conclusion Relative characteristic CT features of pulmonary lymphoma could be revealed, which shows clinical significance in the diagnosis of the disease. Content Type Journal ArticlePages 632-635DOI 10.1007/s10330-011-0831-6Authors Miaoyu Zeng, Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Huanan Hospital, Southern Medical University, Guangzhou, 510080 ChinaZhenjun Zhao, Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Huanan Hospital, Southern Medical University, Guangzhou, 510080 ChinaJine Zhang, Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Huanan Hospital, Southern Medical University, Guangzhou, 510080 ChinaJinlei Li, Department ...

A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma

Blood — Thu, 10 Nov 2011 05:00:00 +0100

Relapsed or refractory (rel/ref) classical Hodgkin lymphoma (cHL) remains a clinical challenge, with limited effective treatment options available after stem cell transplantation. In a multicenter phase 2 study, the efficacy of lenalidomide in rel/ref cHL patients was evaluated at a dose of 25 mg/d on days 1-21 of a 28-day cycle. Patients remained on lenalidomide until disease progression or an unacceptable adverse event (AE) occurred. Thirty-eight cHL patients were enrolled with a median of 4 (range, 2-9) prior therapies; 87% had undergone prior stem cell transplantation and 55% of patients did not respond to their last prior therapy. Of 36 evaluable patients, responses were 1 complete remission (CR), 6 partial remissions (PRs), and 5 patients with stable disease (SD) for ≥ 6 months re...

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Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma

Investigational New Drugs — Wed, 09 Nov 2011 17:56:19 +0100

Conclusion KOS-862 was well tolerated with manageable toxicity, favorable PK profile, and the suggestion of clinical activity. The maximum tolerated dose was determined to be 100 mg/m2 weekly 3-on/1-off. MTBF can be demonstrated in PBMCs of patients exposed to KOS-862. Content Type Journal ArticleCategory PHASE I STUDIESPages 1-9DOI 10.1007/s10637-011-9765-7Authors Jason Konner, Gynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USARachel N. Grisham, Gynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USAJae Park, Gynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan-Kettering Can...

Long-Term Follow-Up Analysis of HD9601 Trial Comparing ABVD Versus Stanford V Versus MOPP/EBV/CAD in Patients With Newly Diagnosed Advanced-Stage Hodgkin's Lymphoma: A Study From the Intergruppo Italiano Linfomi [Hematologic Malignancies]

Journal of Clinical Oncology — Tue, 08 Nov 2011 05:00:00 +0100

Conclusion The long-term analysis confirmed ABVD and MEC superiority to StV. The use of RT after StV was established as mandatory. ABVD is still to be considered as the standard treatment with a good balance between efficacy and toxicity. (Source: Journal of Clinical Oncology)

Eight Cycles of Escalated-Dose BEACOPP Compared With Four Cycles of Escalated-Dose BEACOPP Followed by Four Cycles of Baseline-Dose BEACOPP With or Without Radiotherapy in Patients With Advanced-Stage Hodgkin's Lymphoma: Final Analysis of the HD12 Trial of the German Hodgkin Study Group [Hematologic Malignancies]

Journal of Clinical Oncology — Tue, 08 Nov 2011 05:00:00 +0100

Conclusion The reduction of BEACOPP to the 4 + 4 regimen did not substantially reduce severe toxicity but might decrease efficacy. Our results do not support the omission of consolidation RT for patients with residual disease. Alternative strategies for improving the risk-to-benefit ratio for patients with advanced HL are needed. (Source: Journal of Clinical Oncology)

Teaching NeuroImages: Granulomatous angiitis of the CNS associated with Hodgkin lymphoma

Neurology — Mon, 07 Nov 2011 05:00:00 +0100

(Source: Neurology)

Primary intestinal non-Hodgkin's lymphoma: A clinicopathologic analysis of 81 patients.

World Journal of Gastroenterology : WJG — Mon, 07 Nov 2011 05:00:00 +0100

CONCLUSION: Refined stratification of the patients according to the prognostic variables may allow individualized treatment. Conservative treatment may be an optimal therapeutic modality for selected patients. PMID: 22147970 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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FDA Drug Approvals Having A Good Run

Health News from Medical News Today — Fri, 04 Nov 2011 17:00:00 +0100

The FDA (Federal Drug Administration) is having a good run of drug approvals this year with 35 new medicines and drugs approved in the last 12 months. This is second only to 2009 when 37 new drugs were approved. The new products include important innovations for patients with serious diseases, such as : Two new treatments for hepatitis C A drug for late-stage prostate cancer The first new drug for Hodgkin's lymphoma in 30 years The first new drug for lupus in 50 years Margaret Hamburg, M.D... (Source: Health News from Medical News Today)

Vaccine Could Prevent Mononucleosis And Cancers Linked To Epstein-Barr Virus

Health News from Medical News Today — Fri, 04 Nov 2011 09:00:00 +0100

Epstein-Barr virus (EBV) infects nine out of ten people worldwide at some point during their lifetimes. Infections in early childhood often cause no disease symptoms, but people infected during adolescence or young adulthood may develop infectious mononucleosis, a disease characterized by swollen lymph nodes, fever and severe fatigue. EBV also is associated with several kinds of cancer, including Hodgkin lymphoma and stomach and nasal cancers... (Source: Health News from Medical News Today)

A rare malposition of the central venous catheter

Heart — Fri, 04 Nov 2011 04:00:00 +0100

A 27-year-old Caucasian man with recurrent Hodgkin's disease was admitted to our hospital for treatment. A central venous catheter was inserted through the left subclavian vein. Posteroanterior x-ray of the chest was obtained to confirm the position of the catheter tip (figure 1). Figure 1Postcannulation chest x-ray showing the catheter in the left pericardiacophrenic vein. Subsequently, intravenous contrast medium was injected to delineate the anatomy of the vein. Additionally, a CT scan obtained for staging shortly before was reanalysed (figure 2). It documented the prominent left pericardiacophrenic vein being cannulated. The catheter was removed and chemotherapy was applied via a placed femoral venous device. Figure 2Coronary curved reconstruction of a CT scan illustrates the location...

Plasma thymus and activation-regulated chemokine as an earlyresponse marker in classical Hodgkin lymphoma.

Haematologica — Fri, 04 Nov 2011 04:00:00 +0100

Conclusions:Baseline plasma thymus and activation-regulated chemokine levels correlate with classical Hodgkin lymphoma tumor burden and serial levels correlate with response to treatment in patients with classical Hodgkin lymphoma. PMID: 22058214 [PubMed - as supplied by publisher] (Source: Haematologica)

Volume and attenuation computed tomography measurements for interim evaluation of Hodgkin and follicular lymphoma as an additional surrogate parameter for more confident response monitoring: a pilot study.

Cancer Imaging — Thu, 03 Nov 2011 17:25:02 +0100

Conclusion: Mid-treatment response assessment of residual masses in patients with HD and NHL using VACT may aid in the risk stratification as an additional surrogate parameter. PMID: 22042236 [PubMed - in process] (Source: Cancer Imaging)

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Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma

Blood — Thu, 03 Nov 2011 04:00:00 +0100

Clinical trials have demonstrated that rituximab improves overall survival in non-Hodgkin lymphoma (NHL), except in mantle cell lymphoma (MCL). We used Surveillance Epidemiology and End Results (SEER)–Medicare data to compare survival in older MCL patients who began chemotherapy with or without rituximab within 180 days of diagnosis. Patients were followed from diagnosis (January 1999 to December 2005) until death or the end of observation (December 2007). Medicare administrative and claims data were used to identify the date and cause of death and the immunochemotherapy regimen. Of 638 patients, the mean age at diagnosis was 75 years, 75% had stage III/IV disease, 67% had extranodal involvement, and 64% received rituximab. The average length of first-line treatment was 21 weeks, wit...

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

Blood — Thu, 03 Nov 2011 04:00:00 +0100

Non-Hodgkin lymphoma (NHL) presents as both localized and disseminated disease with spread to secondary sites carrying a worse prognosis. Although pathways driving NHL dissemination have been identified, there are few therapies capable of inhibiting them. Here, we report a novel role for the immunomodulatory protein CD47 in NHL dissemination, and we demonstrate that therapeutic targeting of CD47 can prevent such spread. We developed 2 in vivo lymphoma metastasis models using Raji cells, a human NHL cell line, and primary cells from a lymphoma patient. CD47 expression was required for Raji cell dissemination to the liver in mouse xenotransplants. Targeting of CD47 with a blocking antibody inhibited Raji cell dissemination to major organs, including the central nervous system, and inhibited ...

CD68 and CD163 as prognostic factors for Korean patients with Hodgkin lymphoma

European Journal of Haematology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: Thus, high index of either CD68 or 163 (>20%) is significantly correlated with poor prognosis in Korean HL patients. CD163, a specific marker of macrophages, seems to be another prognostic factor for classical HL. (Source: European Journal of Haematology)

Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients [Original Contribution]

JAMA — Tue, 01 Nov 2011 04:00:00 +0100

Conclusion Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have an increased risk for diverse infection-related and unrelated cancers. (Source: JAMA)

Sir Samuel Wilks (1824-1911): brilliant observer who 'rediscovered' Hodgkin's disease.

British Journal of Hospital Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Ellis H Abstract Guy's Hospital and its medical school rejoiced in a remarkable group of physicians in the 19th century. These included Richard Bright, a pioneer in the study of chronic nephritis, Thomas Addison, who described two diseases that bear his name (Addison's disease of the suprarenals and Addison's, or pernicious, anaemia), Thomas Hodgkin, who gave the first clear account of lymphadenoma and Sir William Gull, who documented myxoedema, its relationship to the thyroid and its resemblance to cretinism in children. PMID: 22083012 [PubMed - in process] (Source: British Journal of Hospital Medicine)

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Ten antibodies, six colours, twelve parameters: A multiparameter flow cytometric approach to evaluate leptomeningeal disease in B‐cell non Hodgkin's lymphomas

Cytometry Part B: Clinical Cytometry — Tue, 01 Nov 2011 04:00:00 +0100

Conclusions.The use of a multiparameter FC approach, which collects an elevated number of monoclonal antibodies in a single tube and identify different cell populations with a selective gating strategy analysis, allows for the evaluation of lymphocyte subsets and the detection of leptomeningeal disease in B‐NHL, even in the presence of paucicellularity of samples. © 2011 International Society for Advancement of Cytometry. (Source: Cytometry Part B: Clinical Cytometry)

Renal cell carcinoma associated with granulomatous reaction.

Saudi Journal of Kidney Diseases and Transplantation — Tue, 01 Nov 2011 04:00:00 +0100

We describe three cases of conventional (clear cell) RCC associated with epithelioid granulomas within the tumor parenchyma. PMID: 22089785 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)

Neck masses confined to the submental space: Our experience with 24 cases.

Ear, Nose and Throat Journal — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Ural A, Imamoğlu M, Umit Işık A, Bahadır O, Bektaş D, Cobanoğlu B, Cobanoğlu U Abstract We conducted a study to identify the clinical and histopathologic features of masses confined to the submental space and to outline an approach to the diagnosis and treatment of these lesions. Our study population was made up of 24 patients-17 males and 7 females, aged 13 to 68 years (mean: 45.88 ± 8.48)-who had undergone surgery at our tertiary care center for the treatment of masses of the submental triangle. Our findings were based on a retrospective review of demographic data, signs and symptoms, diagnostic and therapeutic methods, histopathologic outcomes, and recurrences. Fine-needle aspiration biopsy and ultrasonography were performed on all patients as standard diagnosti...

Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma.

Neoplasia — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Soucek L, Buggy JJ, Kortlever R, Adimoolam S, Monclús HA, Allende MT, Swigart LB, Evan GI Abstract Myc, a pleiotropic transcription factor that is deregulated and/or overexpressed in most human cancers, instructs multiple extracellular programs that are required to sustain the complex microenvironment needed for tumor maintenance, including remodeling of tumor stroma, angiogenesis, and inflammation. We previously showed in a model of pancreatic β-cell tumorigenesis that acute Myc activation in vivo triggers rapid recruitment of mast cells to the tumor site and that this is absolutely required for angiogenesis and macroscopic tumor expansion. Moreover, systemic inhibition of mast cell degranulation with sodium cromoglycate induced death of tumor and endothelial cells in e...

Progressive pericardial effusion during chemotherapy for advanced Hodgkin lymphoma

American Journal of Hematology — Mon, 31 Oct 2011 04:00:00 +0100

(Source: American Journal of Hematology)

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Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome

Neurology — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: Antibodies to mGluR5 should be considered in patients with symptoms of limbic encephalitis and HL (Ophelia syndrome). Recognition of this disorder is important because it can affect young individuals and is reversible. (Source: Neurology)

Hematological malignancy associated with polymyositis and dermatomyositis.

Autoimmunity Reviews — Sun, 30 Oct 2011 04:00:00 +0100

Authors: Marie I, Guillevin L, Menard JF, Hatron PY, Cherin P, Amoura Z, Cacoub P, Bachelez H, Buzyn A, Le Roux G, Ziza JM, Brice P, Munck JN, Sarrot-Reynauld F, Piette JC, Larroche C Abstract The aims of this present study were to: 1) assess the characteristics of hematological malignancies in polymyositis/polymyositis (PM/DM) patients; and 2) determine predictive variables of hematological malignancies in PM/DM patients. We retrospectively reviewed the medical records of 32 patients (14 PM, 18 DM) associated with hematological malignancies. In our 32 PM/DM patients, hematological malignancy was concurrently identified (18.8%) or occurred during the course of PM/DM (31.2%); although, PM/DM more often preceded hematological malignancy onset (50%). We observed that the types of hema...

Papilledema as a diagnostic challenge — report of three cases

Central European Journal of Medicine — Fri, 28 Oct 2011 06:06:13 +0100

We present three different cases of patients with papilledema: one case with a primary tumour of the optic nerve, and two cases with secondary involvement of the optic nerve (breast carcinoma and non-Hodgkin lymphoma). The visual acuity varies from sudden, painless, decrease of vision, to blurred vision and proptosis on the affected eye. A characteristic ophthalmoscopic examination shows a swollen optic disc and promonence with tortuosity of blood vessels. A fluorescein angiography shows dilated capillaries of the optic disc with leakage in the early phase and diffuse hyperfluorescence during the late phase. A ultrasonography B-scan of the affected eye shows prominent optic nerves with widened optic nerve sheath. An exhaustive history and complete ophthalmological examination are ess...

Schistosoma mansoni infection in the liver graft: The impact on donor and recipient outcomes after transplantation

Liver Transplantation — Fri, 28 Oct 2011 05:41:54 +0100

In conclusion, using liver grafts infected with S. mansoni eggs did not compromise the results of LDLT in this pediatric cohort. Because of the parasite's life cycle and the therapeutic target of praziquantel, only donors should be treated for the infection. Three years of follow‐up showed an uneventful recovery for the living donors. Liver Transpl 17:1299–1303, 2011. © 2011 AASLD. (Source: Liver Transplantation)

Treating limited-stage nodular lymphocyte predominant Hodgkin lymphoma similarly to classical Hodgkin lymphoma with ABVD may improve outcome

Blood — Thu, 27 Oct 2011 04:00:00 +0100

The appropriate therapy for limited-stage nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is unclear. In contrast to classical Hodgkin lymphoma (CHL), chemotherapy is often omitted; however, it is unknown whether this impacts the risk of relapse. Herein, we compared the outcome of patients with limited-stage NLPHL treated in an era in which ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy was routinely incorporated into the primary therapy to an earlier era in which radiotherapy (RT) was used as a single modality. Using the British Columbia Cancer Agency Lymphoid Cancer Database, 88 patients with limited-stage NLPHL (stage 1A/1B or 2A, nonbulky disease < 10 cm) were identified. Treatment followed era-specific guidelines: before 1993, (n = 32) RT alone; an...

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Tumor microenvironment composition in pediatric classical hodgkin lymphoma is modulated by age and epstein‐barr virus infection

International Journal of Cancer — Tue, 25 Oct 2011 04:00:00 +0100

AbstractClassical Hodgkin lymphoma (cHL) is characterized by a small number of neoplastic cells in a background of reactive cells. Children and adults differ in constitution and functionality of the immune system and it is possible that there may be age‐related differences in tumor microenvironment composition in cHL. One hundred children with pediatric cHL were studied. Tumor‐infiltrating lymphocytes were analyzed by immunohistochemistry (IHC) and image analysis. Epstein‐Barr virus (EBV) status was determined by EBER‐specific in situ hybridization and IHC. Results were analyzed in the context of age‐group, histological characteristics and clinical follow‐up. EBV‐status was not associated with age‐group. Children <10 years and EBV+ cases were characterized by a more inte...

Potential Link Between Body Weight, Diet And Non-Hodgkin Lymphoma

Health News from Medical News Today — Mon, 24 Oct 2011 08:00:00 +0100

Body weight in young adulthood and diet appeared to be associated with the risk for non-Hodgkin lymphoma, according to results presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, being held Oct. 22-25, 2011. "The causes of non-Hodgkin lymphoma (NHL) are poorly understood, and unfortunately, we don't know very much about specific ways to prevent or lower the risk for this disease," said Kimberly Bertrand, Sc.D., research fellow in the department of epidemiology at the Harvard School of Public Health... (Source: Health News from Medical News Today)

A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin‐s and non‐Hodgkin's lymphoma

American Journal of Hematology — Sat, 22 Oct 2011 04:00:00 +0100

AbstractDarinaparsin is a novel organic arsenic compound that is being developed to improve the efficacy and therapeutic index of arsenic as an antineoplastic agent. It has activity in preclinical models of hematological malignancies and we set out to test it in patients with refractory lymphoma. In this multicenter, phase II trial, patients with relapsed or refractory Hodgkin (HL) and non‐Hodgkin lymphoma (NHL) were treated with darinaparsin 300mg/m2 intravenously daily for 5 consecutive days every 28 days, for up to 6 cycles. The primary endpoint was the overall response rate. Twenty‐nine heavily pretreated patients with lymphoma (22 with NHL and 7 with HL) were enrolled. There was one complete response (CR), 1 unconfirmed CR, 3 partial responses (PR) and 4 with stable disease (SD), ...

Clinical Use of Rituximab in Patients with HIV Related Lymphoma and Multicentric Castleman's Disease.

Current Drug Delivery — Fri, 21 Oct 2011 04:00:00 +0100

Authors: Reid E, Nooka A, Blackmon J, Lechowicz MJ Abstract The use of immunotherapy in the treatment of non-Hodgkin lymphomas has improved response rates and survival in this population. With widespread rituximab use and longer-term follow-up of patients receiving rituximab, infectious complications are increasing. These complications are of great concern in the AIDS-related lymphoma population. We review the data on activity and infectious toxicity of rituximab to date and as it pertains to the treatment of AIDS-related non-Hodgkin lymphoma and Multicentric Castleman's disease. PMID: 22023215 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)

Rare association of Visceral leishmaniasis with Hodgkin's disease: A case report

Infectious Agents and Cancer — Thu, 20 Oct 2011 04:00:00 +0100

We present here a case of young male with complaints of fever and swelling in neck for eight months. History of progressive weakness associated with weight loss was present. Physical examination revealed pallor, multiple enlarged cervical lymph nodes and hepatosplenomegaly. Investigations showed pancytopenia, hyperglobinemia and Leishman-Donovan bodies on bone marrow aspiration. Serological test confirmed diagnosis of visceral leishmaniasis. However, cervical lymph node aspiration and biopsy were suggestive of Mixed cellularity Hodgkin's disease. This made it a very rare case of leishmaniasis as an opportunistic infection in a patient of pre-chemotherapy Hodgkin's disease. There was marked improvement in haematological profile and regression of hepatosplenomegaly with Amphotericin B treatm...

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Phase 2 study of rituximab in newly diagnosed stage IA nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group

Blood — Thu, 20 Oct 2011 04:00:00 +0100

This study was registered at www.clinicaltrials.gov as #NCT00346684. (Source: Blood)

Lack of benefit of central nervous system prophylaxis for diffuse large B‐cell lymphoma in the rituximab era

Cancer — Mon, 17 Oct 2011 04:00:00 +0100

CONCLUSIONS:Given the overall low rate of CNS recurrence and lack of prophylaxis‐associated survival benefit, the current data called into question the practice of CNS prophylaxis in the rituximab era. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Role of high resolution ultrasound in parotid lesions in children

International Journal of Pediatric Otorhinolaryngology — Sat, 15 Oct 2011 08:22:26 +0100

Conclusion: High resolution ultrasound remains the first-line imaging modality for evaluation of the parotid gland. It is sensitive in detection of salivary gland abnormalities. (Source: International Journal of Pediatric Otorhinolaryngology)

SAR3419: An Anti-CD19-Maytansinoid Immunoconjugate for the Treatment of B-Cell Malignancies.

Clinical Cancer Research — Sat, 15 Oct 2011 04:00:00 +0100

Authors: Blanc V, Bousseau A, Caron A, Carrez C, Lutz RJ, Lambert JM Abstract SAR3419 is a novel anti-CD19 humanized monoclonal antibody conjugated to a maytansine derivate through a cleavable linker for the treatment of B-cell malignancies. SAR3419 combines the strengths of a high-potency tubulin inhibitor and the exquisite B-cell selectivity of an anti-CD19 antibody. The internalization and processing of SAR3419, following its binding at the surface of CD19-positive human lymphoma cell lines and xenograft models, release active metabolites that trigger cell-cycle arrest and apoptosis, leading to cell death and tumor regression. SAR3419 has also been shown to be active in different lymphoma xenograft models, including aggressive diffuse large B-cell lymphoma, resulting in complete...

Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin.

Clinical Cancer Research — Sat, 15 Oct 2011 04:00:00 +0100

Authors: Ricart AD Abstract Antibody-drug conjugates (ADC) are an attractive approach for the treatment of acute myeloid leukemia and non-Hodgkin lymphomas, which in most cases, are inherently sensitive to cytotoxic agents. CD33 and CD22 are specific markers of myeloid leukemias and B-cell malignancies, respectively. These endocytic receptors are ideal for an ADC strategy because they can effectively carry the cytotoxic payload into the cell. Gemtuzumab ozogamicin (GO, Mylotarg) and inotuzumab ozogamicin consist of a derivative of calicheamicin (a potent DNA-binding cytotoxic antibiotic) linked to a humanized monoclonal IgG4 antibody directed against CD33 or CD22, respectively. Both of these ADCs have a target-mediated pharmacokinetic disposition. GO was the first drug to prove the...

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Simultaneous necrotizing glomerulonephritis and Hodgkin's lymphoma: a case report and review of the literature

Nephrology Dialysis Transplantation — Fri, 14 Oct 2011 04:00:00 +0100

We describe a case of necrotizing glomerulonephritis in which treatment with cyclophosphamide and steroids led to resolution of lymphadenopathy. Two years later, recrudescent lymphadenopathy was shown to be Hodgkin’s lymphoma, but renal disease did not recur. (Source: Nephrology Dialysis Transplantation)

SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

Blood — Thu, 13 Oct 2011 04:00:00 +0100

B-cell chronic lymphocytic leukemia (CLL), an incurable leukemia, is characterized by defective apoptosis. We found that the SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A) tumor suppressor, is overexpressed in primary CLL cells and B-cell non-Hodgkin lymphoma (NHL) cell line cells. In CLL, increased levels of SET correlated significantly with disease severity (shorter time to treatment and overall survival). We developed SET antagonist peptides that bound SET, increased cellular PP2A activity, decreased Mcl-1 expression, and displayed selective cytotoxicity for CLL and NHL cells in vitro. In addition, shRNA for SET was cytotoxic for NHL cells in vitro. The SET antagonist peptide COG449 inhibited growth of NHL tumor xenografts in mice. These data demonstrate that S...

Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines

BMC Cancer — Wed, 12 Oct 2011 04:00:00 +0100

Conclusions: We suggest that inclusion of the above drugs into PEL chemotherapy protocols may be justified. The heterogeneity in the drug response pattern however indicated that assay-guided individualized therapy might be required to optimize therapeutic response. (Source: BMC Cancer)

Biomarkers for diabetes prediction, pathogenesis or pharmacotherapy guidance? Past, present and future possibilities∧

Diabetic Medicine — Tue, 11 Oct 2011 04:00:00 +0100

AbstractAn ideal biomarker should refine identification of those at risk of disease occurrence or progression, improve prediction of complications of disease, and/or guide and help tailor responses to different therapies. Biomarkers that give insights into disease pathogenesis are also of interest. With this in mind, this review describes biomarker studies relevant to diabetes, focusing on those conducted by the author, his colleagues and collaborators. The review highlights several points. (1) Novel biomarkers may not improve prediction of new‐onset diabetes in a meaningful way beyond what can be achieved with simple measures combined with HbA1c, and a sensible way ahead may be to combine diabetes and cardiovascular disease prediction using HbA1c and such measures. (2) In terms of disea...

Errors in a Study of Proportions of Kaposi Sarcoma, Selected Non-Hodgkin Lymphomas, and Cervical Cancer in the United States Occurring in Persons With AIDS, 1980-2007 [Letters]

JAMA — Tue, 11 Oct 2011 04:00:00 +0100

(Source: JAMA)

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Errors in Data in: Proportions of Kaposi Sarcoma, Selected Non-Hodgkin Lymphomas, and Cervical Cancer in the United States Occurring in Persons With AIDS, 1980-2007 [Correction]

JAMA — Tue, 11 Oct 2011 04:00:00 +0100

(Source: JAMA)

CNS disease in younger patients with aggressive B-cell lymphoma: an analysis of patients treated on the Mabthera International Trial and trials of the German High-Grade Non-Hodgkin Lymphoma Study Group.

Ann Oncol — Tue, 11 Oct 2011 04:00:00 +0100

CONCLUSIONS: In younger patients with aaIPI 0 or 1, CNS relapse/progression is very rare; in patients with aaIPI 2 or 3, the risk is higher (up to 10%) and requires new diagnostic strategies and treatment. PMID: 21989328 [PubMed - as supplied by publisher] (Source: Ann Oncol)

The potential role of pre‐transplant HBcigG seroposivity as predictor of clinically relevant cytomegalovirus infection in patients with lymphoma undergoing autologous hematopoietic stem cell transplantation: A study from the rome transplant network

American Journal of Hematology — Tue, 11 Oct 2011 04:00:00 +0100

AbstractDespite the increased use of intensive immunosuppressive chemo‐immunotherapies in patients with lymphoma observed in the last decade, current data on Cytomegalovirus (CMV) infection following autologous stem cell transplantation (Auto‐SCT) are very limited. To address this peculiar aspect, a retrospective study on a cohort of 128 adult patients consecutively transplanted for lymphoma in 3 Hematology Institutions was performed with the aim to determine the incidence of and the risk factors for CMV symptomatic infection and/or end‐organ disease. Sixteen patients (12.5%) required specific antiviral therapy and 4/16 died (25%); transplant‐related mortality (TRM) was significantly influenced by CMV infection (P=0.005). In univariate analysis, a pre‐transplant HBcIgG seropositi...

Allogeneic stem cell transplantation after reduced intensityconditioning in patients with relapsed or refractory Hodgkin'slymphoma. Results of the HDR-ALLO study - a prospectiveclinical trial by the Grupo Espanol de Linfomas/ Trasplante deMedula Osea (GEL/TAMO) and the Lymphoma Working Party ofthe European Group for Blood and Marrow Transplantation.

Haematologica — Tue, 11 Oct 2011 04:00:00 +0100

Conclusions. Allogeneic stem cell transplantation can result in long-term progression free survival in heavily pre-treated patients with Hodgkin's lymphoma. This reduced intensity conditioning approach has been able to significantly reduce non-relapse mortality; the high relapse rate represents the major remaining challenge in this setting. PMID: 21993674 [PubMed - as supplied by publisher] (Source: Haematologica)

Cause‐specific mortality among a cohort of U.S. flight attendants

American Journal of Industrial Medicine — Mon, 10 Oct 2011 04:00:00 +0100

ConclusionsWe found no evidence of increased breast cancer or melanoma mortality. Limitations include reliance on mortality data and limited power resulting from few melanoma deaths and relatively short employment durations. Am. J. Ind. Med. © 2011 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)

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Sweet's syndrome: study of 73 cases, emphasizing histopathological findings

Anais Brasileiros de Dermatologia — Sun, 09 Oct 2011 05:29:10 +0100

CONCLUSIONS: In general, these findings are in agreement with results published in the literature, emphasizing the frequent finding of eosinophils unrelated to drug use, panniculitis and the rare association with Hodgkin's lymphoma. This is the fifth report of an association between Sweet's syndrome and Hodgkin's disease. (Source: Anais Brasileiros de Dermatologia)

Initial cutaneous manifestation of lymphomas in children

Anais Brasileiros de Dermatologia — Sun, 09 Oct 2011 05:29:10 +0100

Os linfomas cutâneos compreendem um grupo heterogêneo de desordens linfoproliferativas que envolvem a pele e são classificados como um subgrupo dos linfomas não Hodgkin. No período de 1981 a 2007, 100 casos de linfomas em crianças foram admitidos no Serviço de Hematologia, do Hospital das Clínicas da Universidade Federal de Minas Gerais, sendo que nove apresentaram manifestação cutânea inicial. Três pacientes foram classificados como linfoma cutâneo primário e seis como sistêmicos. Sete pacientes apresentaram linfoma de células T, um, linfoma linfoblástico B e um, imunofenótipo indefinido. Nenhum óbito ocorreu nos pacientes com linfoma cutâneo primárioCutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are class...

Validation of the Brazilian Portuguese version of the Medical Outcomes Study-Social Support Survey in Hodgkin's lymphoma survivors

Supportive Care in Cancer — Thu, 06 Oct 2011 05:50:31 +0100

Conclusion Results show good general psychometric properties of the Brazilian version of the MOS-SSS when applied to HL survivors. The three-factor structure identified in this study is in line with a previous validation among Brazilian healthy civil servants. The Brazilian Portuguese version will now be used to evaluate social support and its association with long-term disease outcomes and quality of life of Hodgkin's lymphoma survivors. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00520-011-1292-8Authors Andrea Soares, Hematology and Pathology Services, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, BrazilIrene Biasoli, Hematology and Pathology Services, University Hospital, Federal Univers...

Lymphocyte-Depleted Classical Hodgkin's Lymphoma: A Comprehensive Analysis From the German Hodgkin Study Group [Hematologic Malignancies]

Journal of Clinical Oncology — Thu, 06 Oct 2011 04:00:00 +0100

Conclusion LDCHL has a different pattern from other HL subtypes with more clinical risk factors at initial diagnosis and significantly poorer prognosis. Patients with LDCHL should be treated with modern dose-intense treatment strategies. (Source: Journal of Clinical Oncology)

Minimising critical organ irradiation in limited stage Hodgkin lymphoma: a dosimetric study of the benefit of involved node radiotherapy.

Ann Oncol — Thu, 06 Oct 2011 04:00:00 +0100

CONCLUSIONS: Reduction from IFRT to INRT decreased the volumes of lungs, breasts and thyroid receiving high-dose radiation, suggesting the potential to reduce long-term second malignancy risks. VMAT may be useful for patients with pre-existing heart disease by minimising further cardiac toxicity risks. PMID: 21980193 [PubMed - as supplied by publisher] (Source: Ann Oncol)

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Cancers in Togo from 1984 to 2008: Epidemiological and Pathological Aspects of 5251 Cases

Clinical and Developmental Immunology — Wed, 05 Oct 2011 22:54:55 +0100

Conclusion. This study shows that cancers are frequent in Togo and emphasizes on the necessity of having a cancer register for the prevention and the control of this disease in Togo. (Source: Clinical and Developmental Immunology)

Nobel Prize in Chemistry 2011 – live blog

Guardian Unlimited Science — Wed, 05 Oct 2011 17:23:00 +0100

This year's Nobel Prize in Chemistry has been won by Daniel Shechtman for the discovery of quasicrystalsRead our news story about the award "Nobel prize in chemistry for dogged work on 'impossible' quasicrystals"10.22am: The last of the science Nobel prizes is announced today for contributions to chemistry. To complete our coverage of the week's awards, we will be following events live here.We expect to have the name of the winner, or winners, by around 10.45am UK via the live-streaming video of the announcement from Stockholm which you can watch below.This has already been a fascinating year for the science Nobels, and not only for the breakthroughs and researchers the awards honoured. On Monday, the Nobel committee awarded the medicine prize to three researchers whose work on the immune ...

Chronic viral hepatitis and risk of lymphoid malignancies: A retrospective twelve-year population-based cohort study in Côte d’Or, France

Digestive and Liver Disease — Wed, 05 Oct 2011 04:00:00 +0100

Abstract: Background: The association between hepatitis C infection and lymphoid malignancies is still a matter of debate. The hypothesis of a relationship between hepatitis B and lymphoid neoplasms is more recent and has been far less thoroughly explored.Aim: The aim of this study was to evaluate the association between hepatitis C and B infections and B cell non-Hodgkin and Hodgkin lymphomas.Methods: We took advantage of the co-existence in the French administrative area of Côte d’Or of two specialized registries – one for viral hepatitis and one for haematological diseases – to conduct a population-based, cohort study covering a 12-year period. The databases were anonymized and then linked using a probabilistic model.Results: There were 8234 person-years at risk in the hepatitis ...

Analysis of the -398C/T polymorphism in the perforin gene in oncohematological patients

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSION:One patient was homozygous for the -398T allele. Based on these findings, further studies should be conducted to assess whether the presence of this polymorphism may be a risk factor for the development of hematologic malignancies. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Prevalence of non-Hodgkin lymphomas in São Paulo, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Rosai-Dorfman disease is a self-limiting condition caused by histiocyte proliferation within the sinusoids of lymph nodes and in extranodal tissue. It is a rare disease, particularly in children, that progresses with extensive lymphadenopathy. This paper reports on the case of a 2-year-old child with progressive cervical lymphadenopathy associated with persistent fever and radiological findings suggestive of lymphoma. Histopathological and immunohistochemistry studies of a lymph node biopsy established the diagnosis of Rosai-Dorfman disease. Both lymphadenopathy and fever resolved spontaneously. (Source: Revista Brasileira de Hematologia e Hemoterapia)

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Prevalence of sleep disturbances in children and adolescents with chronic kidney disease

Pediatric Nephrology — Sun, 02 Oct 2011 05:47:47 +0100

Abstract Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to health-related quality of life measurements. We performed a clinic-based survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep...

A Triple-Drug Combination to Prevent Nausea and Vomiting Following BEAM Chemotherapy Before Autologous Hematopoietic Stem Cell Transplantation

Transplantation Proceedings — Sat, 01 Oct 2011 04:00:00 +0100

Conclusions: The triple-drug combination was more effective than ondansetron or palonosetron (+dex) treatments to prevent acute (especially) and delayed nausea and vomiting following BEAM before HSCT. (Source: Transplantation Proceedings)

Gastrointestinal lymphomas: Pattern of distribution and histological subtypes: 10 years experience in a tertiary centre in South India.

Indian Journal of Pathology and Microbiology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusion: In this largest retrospective single centre study from India, we establish that the pattern of distribution of primary GIT lymphomas (PGLs) in India is similar to the western literature in that the stomach is the commonest site of PGL and DLBCL is the commonest histological subtype. Immunoproliferative small intestinal disease cases were seen in this study, which is uncommon in the west. PMID: 22234096 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

[Bright's disease is mentioned in an official Hungarian medical document in the 19th century].

Orvosi Hetilap — Fri, 30 Sep 2011 21:10:33 +0100

Authors: Kiss I Abstract The World Kidney Day was announced for the fifth time in 2011, that calls attention to chronic renal failure as it attains the title of endemic. Richard Bright (1789-1858), a British doctor was the first to recognize and describe the uremic state and the kidney diseases leading to it. There are many aspects that the readers should remember him about especially in connection with the World Kidney Day. During his European study tour's stage in Hungary, he was not so much interested in the country's medical and health conditions, rather in its economic and cultural life, natural history and geography. He travelled to Hungary on two occasions and recorded his experiences in a personal travel documentation illustrated with his own drawings. He finally establishe...

Nodular sclerosing classical Hodgkin lymphoma masquerading as acute suppurative‐necrotizing lymphadenitis

Diagnostic Cytopathology — Fri, 30 Sep 2011 04:00:00 +0100

AbstractThe diagnosis of nodular sclerosing classical Hodgkin lymphoma (NSCHL) by fine‐needle aspiration (FNA) biopsy has historically been a diagnostic challenge due to the usual paucicellularity of the specimen. This case report, and other previously published reports, suggests that there is another facet to the potentially challenging diagnosis of this particular variant of Hodgkin lymphoma (HL): the presence of suppurative‐necrotizing changes mimicking an infectious etiology. The patient presented here underwent FNA biopsy of an acutely enlarged supraclavicular lymph node and cytologic smears showed marked acute inflammation in a background of necrosis. A diagnosis of infectious suppurative lymphadenitis was made at that time. After a negative infectious work‐up with infectious d...

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Rituximab for childhood refractory nephrotic syndrome

Pediatrics International — Thu, 29 Sep 2011 18:45:19 +0100

AbstractSeveral therapies including immunosuppressive agents have been shown to be effective and safe for frequently relapsing nephrotic syndrome/steroid‐dependent nephrotic syndrome (FRNS/SDNS) and steroid‐resistant nephrotic syndrome in children. It is evident, however, that a substantial number of children are still refractory to treatment despite these therapies. Rituximab is a chimeric monoclonal antibody, which inhibits CD20‐mediated B‐cell proliferation and differentiation. It was first introduced for the treatment of B‐cell non‐Hodgkin's lymphoma and was subsequently administered to patients with autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus, or immunocomplex glomerulonephritis. Recently, a number of case reports and non‐controlled clinical tr...

Update: Peripheral T-Cell Lymphomas

Current Hematologic Malignancy Reports — Wed, 28 Sep 2011 05:50:38 +0100

Abstract Peripheral T-cell lymphomas (PTCLs) are a group of biologically heterogeneous but typically aggressive diseases. Progress in understanding and developing optimal therapies for PTCLs has been hampered by disease rarity and only relatively recent recognition of the importance of the T-cell phenotype. The International Peripheral T-cell Lymphoma Project was a large collaborative effort to provide a broader understanding of prognosis. Recently, several new therapies have shown promise in the treatment of PTCLs. Content Type Journal ArticleCategory Intermediate- and High-Grade Non-Hodgkin Lymphoma (Andre Goy, Section Editor)Pages 1-9DOI 10.1007/s11899-011-0100-3Authors Kerry J. Savage, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Ca...

An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients

BMC Cancer — Wed, 28 Sep 2011 04:00:00 +0100

Conclusion: We found CTA expression in 21.1% of cHL samples using our panel. Our preliminary findings suggest that from all CTAs included in this study, MAGE-A family and MAGE-C1/CT7 are the most interesting ones to be explored in further studies. (Source: BMC Cancer)

Tubulointerstitial injury and the progression of chronic kidney disease

Pediatric Nephrology — Tue, 27 Sep 2011 05:49:46 +0100

This article reviews the mechanisms of this negative cycle mediating CKD. Content Type Journal ArticleCategory Educational ReviewPages 1-9DOI 10.1007/s00467-011-1992-9Authors Kavita S. Hodgkins, Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children’s Memorial Hospital, Chicago, IL, USAH. William Schnaper, Division of Kidney Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children’s Memorial Hospital, Chicago, IL, USA Journal Pediatric NephrologyOnline ISSN 1432-198XPrint ISSN 0931-041X (Source: Pediatric Nephrology)

Blood Cancer Awareness Month: Lymphoma Lesson

About.com Lymphoma — Tue, 27 Sep 2011 04:00:00 +0100

In honour of Leukemia and Lymphoma Awareness Month, I am blogging about a different type of blood cancer to spread the word about these diseases. Today, let's learn more about lymphoma! What is Lymphoma? What is Hodgkin Lymphoma? What is Non- Hodgkin Lymphoma? Treatment Options for Hodgkin Lymphoma Treatment of Non- Hodgkin Lymphoma (Source: About.com Lymphoma)

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Rituximab for Mantle Cell Lymphoma (updated May 2011)

NeLM - Drug Specific Reviews — Mon, 26 Sep 2011 04:00:00 +0100

Source: London Medicines Information Service Area: Evidence > Drug Specific Reviews Mantle cell lymphoma (MCL) is a rare, aggressive, distinct subtype of B-cell non-Hodgkin's lymphoma (NHL), usually occurring in older adults. In most patients the tumour has an aggressive behaviour, and the majority present with advanced-stage disease. MCL usually responds to chemotherapy, only to relapse frequently, with a much shorter duration of response, time to progression, and overall survival compared to follicular NHL. The treatment approach for newly diagnosed patients generally depends on whether they are transplant-eligible. Only a small minority of patients achieve sustained remission after first-line therapy, and sequential therapies must normally be used. For years the standard treatment ...

Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation.

Transfusion — Mon, 26 Sep 2011 04:00:00 +0100

CONCLUSION: CD26++ lymphocytes define a discrete phenotype of T memory cells with known chemoresistance and T-cell-repopulating capacity. Their enrichment during apheresis and corresponding depletion from the circulation are associated with an adverse outcome in autologous HPCT. PMID: 21950525 [PubMed - as supplied by publisher] (Source: Transfusion)

BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients

Blood — Thu, 22 Sep 2011 04:00:00 +0100

In conclusion, the new BeEAM regimen is safe and effective for heavily pretreated lymphoma patients. The study was registered at European Medicines Agency (EudraCT number 2008-002736-15). (Source: Blood)

Primary pituitary lymphoma in an immunocompetent patient: a rare clinical entity

Journal of Neurology — Tue, 20 Sep 2011 05:51:07 +0100

We report the case of a 41-year-old woman with initial polydipsia and polyuria. When laboratory evaluation revealed panhypopituitarism, a pituitary enhanced MRI was performed and was suggestive of a pituitary adenoma. Obstructive hydrocephalus provoked by enlarged sellar mass was also demonstrated during observation, and a shunt procedure following lesion resection was carried out. Histopathological examination and immunophenotyping verified diffuse large B-cell non-Hodgkin's lymphoma. No systemic disease was found on staging of the patient. We will also review the clinical, radiological features and outcomes of 28 cases that have been reported since 1993. Content Type Journal ArticleCategory Original CommunicationPages 1-9DOI 10.1007/s00415-011-6179-6Authors Yaxiong Li, Depart...