MedWorm: Inflammatory Breast Cancer

Personal Injury Suit Seeking Medical Monitoring For Cancer Removed In Louisiana

LexisNexis® Mealey's™ Emerging Toxic Torts Legal News — Thu, 09 Feb 2012 00:16:44 +0100

NEW ORLEANS - Three oil extraction companies filed notice Jan. 24 in the U.S. District Court for the Eastern District of Louisiana to remove the personal injury lawsuit of a pipe maintenance worker who alleges that exposure to naturally occurring radioactive material causes him an increased risk of developing cancer (Dwayne Rickson v. Exxon Mobil Corp., et al., No. 12-217, E.D. La.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)

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Fat injection reconstruction combo shows promise

Modern Medicine — Wed, 08 Feb 2012 23:47:51 +0100

A new technique involving injections of fat followed by implant placement may prove a viable alternative for breast cancer patients who have undergone radiation therapy. (Source: Modern Medicine)

FDA panel votes against wider use of Amgen drug

Reuters: Health — Wed, 08 Feb 2012 23:15:35 +0100

WASHINGTON (Reuters) - An advisory panel on Wednesday recommended that U.S. health regulators reject the use of Amgen Inc's drug Xgeva to delay the spread of prostate cancer to the bone, dimming the chance of a wider use for one of the company's key growth drivers. (Source: Reuters: Health)

New treatment deep freezes ovarian tumors

USATODAY.com Health — Wed, 08 Feb 2012 21:46:34 +0100

A promising approach for treating advanced ovarian cancer offers new hope for extending survival rates and for preventing tumors from recurr ... (Source: USATODAY.com Health)

Impact of early reoperation after resection for colorectal cancer on long‐term oncological outcomes

Colorectal Disease — Wed, 08 Feb 2012 21:05:54 +0100

Conclusions Compared with non‐reoperated patients matched for patient, tumour and operative characteristics, patients reoperated in the early postoperative period have worse long‐term oncological outcomes. Adoption of strategies to reduce the risk of reoperation may be associated with the additional advantage of improved oncological outcomes in addition to the short‐term advantages. (Source: Colorectal Disease)

Short‐course preoperative radiotherapy prior to abdominoperineal resection for Stage I low rectal cancer; evidence based or defensive medicine?

Colorectal Disease — Wed, 08 Feb 2012 21:05:39 +0100

(Source: Colorectal Disease)

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Re: A proposal for the annotation of recurrent colorectal cancer

Colorectal Disease — Wed, 08 Feb 2012 21:05:37 +0100

(Source: Colorectal Disease)

Outcome of right‐ and left‐sided colonic and rectal cancer following surgical resection Suttie SA, Shaikh I, Mullen R et al. Colorectal Dis 2011; 13: 884–9.

Colorectal Disease — Wed, 08 Feb 2012 21:05:33 +0100

(Source: Colorectal Disease)

Adherence to national guidelines for surveillance after curative resection of nonmetastatic colon and rectum cancer: a survey among Norwegian gastrointestinal surgeons

Colorectal Disease — Wed, 08 Feb 2012 21:05:13 +0100

Conclusion All hospitals reported having a strategy for surveillance after surgery for colon and rectal cancer, but there was considerable variance in strategy. A scientific audit of the true level of compliance, effectiveness and cost‐benefit is warranted at a national level. (Source: Colorectal Disease)

Initial results of a randomized controlled trial comparing clinical and pathological downstaging of rectal cancer after preoperative short‐course radiotherapy or long‐term chemoradiotherapy, both with delayed surgery

Colorectal Disease — Wed, 08 Feb 2012 21:05:04 +0100

Conclusion Long‐course preoperative chemoradiation resulted in greater statistically significant tumour downsizing and downstaging compared with short‐term radiation, but there was no difference in the R0 resection rates. Similar postoperative morbidity was observed in each group. (Source: Colorectal Disease)

Co‐publication agreement between Colorectal Disease and the Cochrane Colorectal Cancer Group

Colorectal Disease — Wed, 08 Feb 2012 21:04:56 +0100

(Source: Colorectal Disease)

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FDA Panel Turns Down Bone Drug in Prostate Ca

MedPage Today Hematology/Oncology — Wed, 08 Feb 2012 20:43:08 +0100

WASHINGTON (MedPage Today) -- An FDA panel has voted 12-1 against expanding the indication for Amgen's denosumab (Xgeva) to prevent the spread of prostate cancer to the bones in men with a high-risk form of the disease. (Source: MedPage Today Hematology/Oncology)

Fasting Might Boost Chemo's Cancer-Busting Properties

Scientific American Topic - Medical Technology — Wed, 08 Feb 2012 19:30:00 +0100

Cancer treatment can be brutal for patients. Many of the tools we have-- chemotherapy , radiation--are big, blunt weapons that deal punishing blows to healthy tissues along with cancerous ones. So the hunt has been on for more and more finely targeted therapies that will attack malignant cells yet minimize damage to patients' bodies. [More] (Source: Scientific American Topic - Medical Technology)

FDA Panel Votes Against Expanding Use of Amgen Drug Xgeva

WSJ.com: Health — Wed, 08 Feb 2012 19:27:13 +0100

A federal advisory panel rejected a proposal by Amgen to expand the use of its bone drug Xgeva in men with prostate cancer that has not spread to the bones. (Source: WSJ.com: Health)

Roche Breast Cancer Drug Gets FDA Priority ReviewRoche Breast Cancer Drug Gets FDA Priority Review

Medscape Medical News Headlines — Wed, 08 Feb 2012 18:52:05 +0100

U.S. health regulators granted a priority review for an experimental Roche breast cancer drug that in clinical trials added six months to progression-free survival. Reuters Health Information (Source: Medscape Medical News Headlines)

Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway

Advances in Pharmacological Sciences — Wed, 08 Feb 2012 18:37:00 +0100

In conclusion, this research elucidates the effects and molecular mechanism for antimigration of PS-A on RCC cells and suggests PS-A to be a therapeutic or adjuvant strategy for the patients with aggressive RCC. (Source: Advances in Pharmacological Sciences)

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Breathalyzer Device Identifies Glucose Metabolism Problems Accurately

Health News from Medical News Today — Wed, 08 Feb 2012 18:00:00 +0100

According to a study published in the peer-reviewed journal Metabolism, a "breathalyzer"-like technology, currently under development at the University of Wisconsin-Madison, may help diagnose diseases in the future. The study shows a simple, but sensitive technique, that can identify normal and disease-state glucose metabolism by a fast analysis of exhaled air or blood. Several diseases, including infections, diabetes, and cancer, change the body's metabolism in different ways... (Source: Health News from Medical News Today)

Soy Isoflavone Supplementation Not Effective In Breast Cancer Protection

Health News from Medical News Today — Wed, 08 Feb 2012 18:00:00 +0100

A study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, reveals that breast cancer cell proliferation was not lowered with soy isoflavone supplements in a randomized human trial. Isoflavone are components of soy foods believed to have anti-estrogen activity. Results of the study are consistent with findings from earlier investigations that were designed to examine cancer prevention benefits of dietary supplements, according to lead researcher Seema A. Khan, M.D., professor of surgery at the Robert H... (Source: Health News from Medical News Today)

Slow-Growing Prostate Cancer Is Still 'Real Cancer'Slow-Growing Prostate Cancer Is Still 'Real Cancer'

Medscape Today Headlines — Wed, 08 Feb 2012 17:48:30 +0100

Two prostate cancer experts put forward a strong argument against taking the emotionally charged term "cancer" out of the diagnosis. Medscape Medical News (Source: Medscape Today Headlines)

'Economy class' DVT syndrome myth busted

NHS News Feed — Wed, 08 Feb 2012 17:30:00 +0100

“Sitting in a window seat during a long flight can increase the risk of deep vein thrombosis,” according to The Daily Telegraph. It has long been known that flying is associated with an increased risk of deep vein thrombosis (DVT), a type of serious blood clot in a major vein, but new US guidance has looked at a range of factors that could potentially raise the risk. Those of you thinking of booking your summer holiday might be interested to know that flying in cramped budget seats, while often annoying, presented no greater risk than flying in business class. And while overpriced booze available during a flight can prove wallet-damaging, the guidelines say there was no firm evidence that drinking it could bring on DVT. However, sitting by a window during a long-haul flight was associa...

Insight: Komen charity under microscope for funding, science

Reuters: Health — Wed, 08 Feb 2012 17:22:40 +0100

NEW YORK (Reuters) - The Susan G. Komen for the Cure charity defines its mission as finding a cure for breast cancer. In recent years, however, it has cut by nearly half the proportion of fund-raising dollars it spends on grants to scientists working to understand the causes and develop effective new treatments for the disease. (Source: Reuters: Health)

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Proton Therapy for Prostate Cancer: Benefits Overblown?Proton Therapy for Prostate Cancer: Benefits Overblown?

Medscape Today Headlines — Wed, 08 Feb 2012 17:18:43 +0100

A society for radiation oncologists touts new studies on the benefits of proton radiation therapy in prostate cancer, but is the evidence really solid? Dr. Gerald Chodak discusses the issue. Medscape Urology (Source: Medscape Today Headlines)

When Will This Woman Need Palliative Care?When Will This Woman Need Palliative Care?

Medscape Today Headlines — Wed, 08 Feb 2012 15:31:35 +0100

Learn when to begin palliative care in this case of a woman who has just been diagnosed with lung cancer. Medscape Nurses (Source: Medscape Today Headlines)

Potential clinical applications of halichondrins in breast cancer and other neoplasms

Vascular Health and Risk Management — Wed, 08 Feb 2012 14:05:29 +0100

Ortega V, Cortes J (Source: Vascular Health and Risk Management)

Adjuvant Chemotherapy Slows Gastric CancerAdjuvant Chemotherapy Slows Gastric Cancer

Medscape Today Headlines — Wed, 08 Feb 2012 13:27:06 +0100

When gastric cancer is operable, a chemotherapy combination improves disease-free survival after surgery, according to a large trial. Medscape Medical News (Source: Medscape Today Headlines)

Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

The objective of this study was to identify genes altered by carcinogen treatment in normal-appearing colonic mucosa and those attenuated by bean feeding. Ninety-five male F344 rats were fed control (AIN) diets upon arrival. At 4 and 5 weeks, rats were injected with AOM (15 mg/kg) or saline and one week later administered an AIN, BB-, or SF-based diet. Rats were sacrificed after 31 weeks, and microarrays were conducted on RNA isolated from the distal colonic mucosa. AOM treatment induced a number of genes involved in immunity, including several MHC II-associated antigens and innate defense genes (RatNP-3, Lyz2, Pla2g2a). BB- and SF-fed rats exhibited a higher expression of genes involved in energy metabolism and water and sodium absorption and lower expression of innate (RatNP-3, Pl...

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Editorial Board

Lung Cancer — Wed, 08 Feb 2012 13:23:50 +0100

(Source: Lung Cancer)

Lung Cancer — Wed, 08 Feb 2012 13:23:50 +0100

(Source: Lung Cancer)

Repeat flexible sigmoidoscopy increases colorectal cancer detection rate

MedWire News - Oncology — Wed, 08 Feb 2012 13:23:41 +0100

Repeat screening by flexible sigmoidoscopy after 3 to 5 years increases the detection of colorectal cancer or advanced adenoma by a quarter in women and by a third in men, show results of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. (Source: MedWire News - Oncology)

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

Journal of Surgical Oncology — Wed, 08 Feb 2012 13:14:09 +0100

The objective of this study was to compare survival between all patients with radiographically resectable adenocarcinoma of the proximal pancreas who underwent preoperative chemoradiation therapy (PRE‐OP CRT) or surgical exploration first (SURGERY) with “intention to resect.” Pancreatic cancer patients who undergo resection after PREOP CRT live longer than patients who undergo resection without PREOP CRT, a difference that may be attributable to patient selection. We retrospectively identified 236 patients with pancreatic head adenocarcinoma seen between 1999 and 2007 with sufficient data to be confirmed medically and radiographically resectable. The outcomes of 144 patients who underwent PREOP CRT were compared to those of 92 patients who proceeded straight to SURGERY. The groups we...

FDA Grants Imatinib (Gleevec) Full Approval for Adjuvant Treatment of GIST

Cancer Network — Wed, 08 Feb 2012 13:00:02 +0100

The FDA has granted imatinib full approval as an adjuvant treatment following surgical removal of CD117-positive gastrointestinal stromal tumors in adult patients. This comes after results from a phase III trial showed that patients taking imatinib for 36 months had a 5-year overall survival of 92%, compared to 82% for those patients who took the drug for the standard 12 months of treatment. (Source: Cancer Network)

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The Great Prostate Debate: Does Screening Save Lives? (preview)

Scientific American Topic - Medical Technology — Wed, 08 Feb 2012 13:00:00 +0100

Last fall the U.S. Preventive Services Task Force dropped a bombshell, arguing that healthy men should stop undergoing a routine blood test as a screen for prostate cancer. An analysis of the best available evidence, it argued, had shown little or no long-term benefit from the measure--called the prostate-specific antigen (PSA) test--for most men with no symptoms of the disease. Use of the screening was not saving lives. In fact, it was needlessly exposing hundreds of thousands of men who were tested and found to have prostate cancer to such common complications as impotence and urinary incontinence (from surgical removal of the prostate) and rectal bleeding (from radiation treatment). Indeed, the task force estimated that more than one million men have been treated because of PSA testing ...

The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: Do liver metastases have a negative impact on survival?

Pediatric Blood and Cancer — Wed, 08 Feb 2012 12:57:11 +0100

ConclusionsIn Africa liver metastases do not appear to worsen the prognosis of children with Stage IV WT. Despite the poor socio‐economic circumstances survival is comparable to other countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Methyleseleninic acid downregulates aromatase

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Cytochrome P 450 aromatase (CYP19) is the key enzyme required for oestrogen biosynthesis and is responsible for converting androgens to oestrogens. Oestrogen is known to play a critical role in breast cancer development and progression, making aromatase an important target for breast cancer prevention and therapy. Although aromatase inhibitors have been used as first line of therapy for oestrogen receptor-positive breast cancer in post menopausal women, their use has been limited by toxicities and high costs. Gao et al. show that methylseleninic acid (MSA), can effectively suppress aromatase activation by dexamethasone and forskolin. MSA suppression of aromatase activation is not mediated through direct inhibition of aromatase enzymatic activity but is attributable to a marked downregulati...

RSUME regulates VEGF-A in pituitary tumours

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

In this study, they demonstrate RSUME expression in pituitary adenomas and its involvement in the regulation of HIF-1? and VEGF-A production in these tumours, suggesting an important role of RSUME in the process of pituitary adenoma neovascularisation. Their study suggests that the novel RWD-domain containing protein RSUME is a new and important player in pituitary tumour pathogenesis. It is overexpressed in human pituitary adenomas and critically regulates HIF-1? expression and VEGF-A production under hypoxia. Through supporting pituitary tumour neovascularisation, RSUME might be critically involved in pituitary adenoma progression. Therefore, it represents a new putative therapeutic target for the development of novel anti-angiogenic treatment concepts of human pituitary tumours. Shan et...

RSUMEs in pituitary adenomas

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Pituitary tumourigenesis remains poorly understood as a process, although several promising candidate genes have been identified. The lack of genuine marker genes within pituitary tumours has led investigators to focus on alternative angles to improve the understanding of potential mechanisms of pathogenesis. In the current issue of Endocrine-Related Cancer, Shan et al. (2012) report that the novel RWD domain containing protein, RWD-containing sumoylation enhancer, is expressed in human pituitary adenomas and plays a pivotal role in regulating the hypoxia-inducible factor 1?–vascular endothelial growth factor response to hypoxia (full article at DOI: 10.1530/ERC-11-0211). Fowkes and Vlotides have a written a commentary on this work and state that these findings expand our understan...

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MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

In this study, a new method, MOfinder, was developed to detect overlapping modules in a protein-protein interaction (PPI) network. We demonstrate that our method is more accurate than other 5 methods. Then, we applied MOfinder to yeast and human PPI network and explored the overlapping information. Using the overlapping modules of human PPI network, we constructed the module-module communication network. Functional annotation showed that the immune-related and cancer-related proteins were always together and present in the same modules, which offer some clues for immune therapy for cancer. Our study around overlapping modules suggests a new perspective on the analysis of PPI network and improves our understanding of disease. (Source: Clinical and Developmental Immunology)

Leptin in Anorexia and Cachexia Syndrome

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and food intake is not followed by a compensatory increase in appetite or decreased EE. Crosstalk between leptin and inflammatory signaling known to be activated in these condi...

Targeting HLA class I expression to increase tumor immunogenicity

Tissue Antigens — Wed, 08 Feb 2012 11:12:45 +0100

The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor‐associated antigens (TAA) by self‐HLA (human leukocyte antigen) class I‐restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at increasing tumor immunogenicity and T‐cell‐mediated anti‐tumor immunity. Unfortunately, while these new protocols of cancer immunotherapy are mediating induction of tumor‐specific T lymphocytes in patients with certain malignancies, they have not yet delivered substantial clinical benefit...

Three Florida hospitals collaborate to advance personalized medicine

CMIO.net: The News Weekly for Health IT Executives — Wed, 08 Feb 2012 09:44:10 +0100

Three Florida healthcare institutions will collaborate to create Personalized Medicine Partnership of Florida (PMP Florida), which will conduct collaborative research on cancer and metabolic diseases. (Source: CMIO.net: The News Weekly for Health IT Executives)

The impact of lung cancer on patients and carers.

Chronic Respiratory Disease — Wed, 08 Feb 2012 09:06:02 +0100

This article aims to provide a brief review of the literature with regard to the impact of lung cancer on patients and their informal carers. Compared to other types of cancer, the distress associated with lung cancer has been found to be the most intense. Rather than focusing on symptoms in isolation recent emphasis regarding the symptom experience has been on symptoms clusters, as understanding these clusters may improve the management of ongoing and unrelieved symptoms. However, the disparities in methodology are significant barriers to producing comparable results, although recent efforts have been made to address these. Whilst research into symptoms has enormous potential for the management of symptom clusters, it needs to move away from the essentially reductionist stance which curre...

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Key Finding In Stem Cell Self-Renewal

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

A University of Minnesota-led research team has proposed a mechanism for the control of whether embryonic stem cells continue to proliferate and stay stem cells, or differentiate into adult cells like brain, liver or skin. The work has implications in two areas. In cancer treatment, it is desirable to inhibit cell proliferation. But to grow adult stem cells for transplantation to victims of injury or disease, it would be desirable to sustain proliferation until a sufficient number of cells have been produced to make a usable organ or tissue... (Source: Health News from Medical News Today)

Early Signs Of Disease Detected By Metabolic 'Breathalyzer'

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

The future of disease diagnosis may lie in a "breathalyzer"-like technology currently under development at the University of Wisconsin-Madison. New research published online in February in the peer-reviewed journal Metabolism demonstrates a simple but sensitive method that can distinguish normal and disease-state glucose metabolism by a quick assay of blood or exhaled air. Many diseases, including diabetes, cancer, and infections, alter the body's metabolism in distinctive ways... (Source: Health News from Medical News Today)

For Personalizing Cancer Therapy, Metabolic Profiles Are Essential

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all. That means that metabolic profiling will be essential for defining each cancer and choosing the best treatment accordingly, the researchers say. The evidence comes from studies in mice showing that tumors' metabolic profiles vary based on the genes underlying a particular cancer and on the tissue of origin... (Source: Health News from Medical News Today)

Women Born To Older Mothers Have A Higher Risk Of Developing Breast Cancer

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

A new study analyses the influence that certain birth and infancy characteristics have on mammographic density - an important indicator of breast cancer risk. The results reveal that women born to mothers aged over 39 years and women who were taller and thinner than the average girl prior to puberty have a higher breast density. This brings with it an increased risk of developing breast cancer... (Source: Health News from Medical News Today)

Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

The body's control mechanisms for delivering zinc to cells could be key to improving treatment for some types of aggressive breast cancer. New research by Cardiff University and King's College London has identified the switch which releases zinc into cells, with important implications for a number of diseases. Zinc has long been known to play a vital part in human health. Too much zinc, or too little, can cause cell death. A growing body of evidence links zinc to disease states including neurodegeneration, inflammation, diabetes and cancer... (Source: Health News from Medical News Today)

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Patient Sensitivity To Important Drug Target In Deadly Brain Cancer Predicted

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma - the most common and most aggressive malignant brain tumor in humans. The study, published in the Proceedings of the National Academy of Science, investigated glioblastoma models characterized by cell signaling activation and gene amplification for their susceptibility to inhibitors of both the human MET oncogene and the epidermal growth factor receptor (EFGR). An oncogene is a gene with the potential to cause cancer... (Source: Health News from Medical News Today)

More Accurate Diagnosis, Prognosis In Challenging Breast Cancer Cases Provided By PET Techniques

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

In two new studies featured in the February issue of The Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult cases of breast cancer. One article focuses on an imaging agent that targets estrogen receptors in estrogen receptor-positive breast cancer patients with formerly inconclusive assessments, and the second highlights a different imaging agent's ability to help predict the prognosis for patients undergoing chemotherapy for a very aggressive type of breast cancer... (Source: Health News from Medical News Today)

Breast cancer screening benefits are oversold and harms could be greater than thought

the Mail online | Health — Wed, 08 Feb 2012 07:50:40 +0100

Danish scientist Professor Peter Gotzsche warned that evidence in favour of screening had become weaker as treatments have improved. (Source: the Mail online | Health)

Men with low-risk prostate cancer may benefit from dutasteride, active surveillance

HemOncToday.com — Wed, 08 Feb 2012 07:38:00 +0100

Fleshner NE. Lancet. 2012;doi:10.1016/S0140-6736(11)61619-X. (Source: HemOncToday.com)

After Outcry, Karen Handel Resigns From Komen

NYT — Wed, 08 Feb 2012 06:04:06 +0100

Karen Handel’s resignation came just days after the cancer foundation reversed its decision to cut funds to Planned Parenthood. (Source: NYT)

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Research partnership to improve treatments for cancer patients

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(Walter and Eliza Hall Institute) The Australian Cancer Research Foundation has committed $2 million towards the fit-out of two new cancer research laboratories at the Walter and Eliza Hall Institute. (Source: EurekAlert! - Medicine and Health)

Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

Breast Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Smad proteins are the key intermediates of TGF-beta-signaling during development and in tissue homeostasis. Pertubations in TGF-beta/Smad signaling have been implicated in cancer, and other diseases. In the cell nucleus Smad complexes trigger cell type- and context-specific transcriptional programs, thereby transmitting and integrating signals from a variety of ligands of the TGF-beta-superfamily and other stimuli in the cell micro-environment. The actual transcriptional and biological outcome of Smad activation critically depends on the genomic integrity and the modification state of genome and chromatin of the cell. The cytoplasmic and nuclear Smads can also modulate the activity of other signal transducers and enzymes such as microRNA processing factors. In the case of breast cancer the...

The role and function of cadherins in the mammary gland

Breast Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Cadherins are transmembrane receptors that function through calcium-dependent homophilic and heterophilic interactions that provide cell-cell contact and communication in many different organ systems. In the mammary gland only a few of the cadherins that make up this large superfamily of proteins have been characterized. Frequently in metastatic breast cancer, the genes for cadherins are epigenetically silenced, mutated, or regulated differently. During epithelial mesenchymal transition, cadherins that are expressed normally in the epithelial cells are down regulated, while cadherins expressed in the mesenchyme are up regulated. This process is known as cadherin switching, and its regulation can sometime facilitates the increase motility, invasiveness and proliferation that occurs in meta...

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: A randomized controlled trial

BMC Cancer — Wed, 08 Feb 2012 05:00:00 +0100

DiscussionResults of this study will contribute to the evidence base about effective strategies to a) improve adherence to surveillance recommendation for people with CRC; and b) improve adherence to screening recommendation for FDRs of people with CRC. The use of a population-based cancer registry to access the target population may have significant advantages in increasing the reach of the intervention. (Source: BMC Cancer)

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Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation

Journal of Experimental and Clinical Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Conclusion: Overexpression of GADD45alpha gene is due to DNA hypomethylation in ESCC. GADD45alpha may be a protective factor in DDP chemotherapy for esophageal squamous cell carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)

basics of lymphedema

About.com Breast Cancer — Wed, 08 Feb 2012 05:00:00 +0100

Lymphedema is swelling that occurs due to the accumulation of lymphatic fluid (also called lymph) in an arm, or sometimes a leg. Many people who've undergone treatment for breast cancer worry about developing lymphedema. What are the symptoms of lymphedema to be on the lookout for? Arm yourself with knowledge about who gets lymphedema, how it is diagnosed, and how it is treated. (Source: About.com Breast Cancer)

Top9ColCanRiskFactors

About.com Colon Cancer — Wed, 08 Feb 2012 05:00:00 +0100

Many of the top nine colon cancer risk factors are things you can change. Take the steps needed for better health and eliminate many of your colon cancer risk factors, too. (Source: About.com Colon Cancer)

Personalizing Cancer Therapy

Medical Headlines From Ivanhoe.com — Wed, 08 Feb 2012 05:00:00 +0100

(Ivanhoe Newswire)-- When fighting tumors it is essential doctors target the metabolic reactions that fuel their growth. (Source: Medical Headlines From Ivanhoe.com)

Heart disease may be a risk factor for prostate cancer

EurekAlert! - Social and Behavioral Science — Wed, 08 Feb 2012 05:00:00 +0100

(Duke University Medical Center) In a large analysis of men participating in a prostate drug trial, researchers at the Duke Cancer Institute found a significant correlation between coronary artery disease and prostate cancer, suggesting the two conditions may have shared causes. (Source: EurekAlert! - Social and Behavioral Science)

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Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(Sanford-Burnham Medical Research Institute) Moffitt Cancer Center, Sanford-Burnham Medical Research Institute and Florida Hospital have announced they will collaborate on the creation of a Personalized Medicine Partnership of Florida. The partnership will conduct collaborative research to accelerate discovery and develop new treatments in the areas of cancer and metabolic diseases, including obesity, diabetes and cardiovascular disease. (Source: EurekAlert! - Medicine and Health)

Moffitt Cancer Center teams with Ponce School of Medicine in Puerto Rico

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(H. Lee Moffitt Cancer Center & Research Institute) A description of the projects and studies resulting from a research partnership initiated in 2005 between Moffitt Cancer Center in Tampa, Fla., and the Ponce School of Medicine in Ponce, Puerto Rico, has been published in a recent issue of Health Promotion Practice. The partnership included three outreach cancer education projects and two pilot research studies aimed at reducing cancer health disparities in Hispanic populations in both Tampa and Ponce. (Source: EurekAlert! - Medicine and Health)

London Cancer New Drugs Group Rapid Review:Erlotinib for the first-line treatment of advanced NSCLC with EGFR mutation

NeLM - Drug Specific Reviews — Wed, 08 Feb 2012 05:00:00 +0100

Source: London Cancer New Drugs Group Area: Evidence > Drug Specific Reviews Current NICE-approved first-line treatments for patients with NSCLC who have EGFR activating mutations include platinum-doublet chemotherapy (mainly gemcitabine plus cisplatin or carboplatin in the UK), gefitinib, and pemetrexed plus cisplatin (for adenocarcinoma or large-cell carcinoma only). Erlotinib has recently had its license extended to include the first-line treatment of patients with locally advanced or metastatic NSCLC with EGFR activating mutations. In the European registration Phase III study (EURTAC), erlotinib at a dose of 150mg daily continued until disease progression (or unacceptable toxicity) resulted in a PFS gain of 4.5 months compared to standard chemotherapy; survi...

Potactasol 4mg powder for concentrate for solution for infusion (topotecan)- New Product

NeLM - SPC Changes — Wed, 08 Feb 2012 05:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Actavis has launched Potactasol 4mg powder for concentrate for solution for infusion (topotecan). Topotecan monotherapy is indicated for the treatment of patients with metastatic carcinoma of the ovary after failure of first-line or subsequent therapy and patients with relapsed small cell lung cancer (SCLC) for whom re-treatment with the first-line regimen is not considered appropriate. It can be used in combination with cisplatin for patients with carcinoma of the cervix recurrent after radiotherapy and for patients with Stage IVB disease. Please refer to the link below for the New SPC for new product Potactasol powder for concentrate for solution for infusion. (S...

Horizon scanning: FDA Grants priority review of pertuzumab for untreated HER2-Positive metastatic breast cancer

NeLM - News — Wed, 08 Feb 2012 05:00:00 +0100

Source: BioSpace Area: News According to a Biospace report, the U.S. Food and Drug Administration (FDA) has granted Priority Review for pertuzumab in combination with trastuzumab and docetaxel chemotherapy for people with HER2-positive metastatic or locally recurrent, unresectable breast cancer, who have not received previous treatment or whose disease has relapsed after adjuvant therapy. (Source: NeLM - News)

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Fasting weakens cancer in mice

EurekAlert! - Social and Behavioral Science — Wed, 08 Feb 2012 05:00:00 +0100

(University of Southern California) The centuries-old practice of fasting treats several cancers in animals as well as toxic pharmaceuticals. Researchers also find that fasting makes chemotherapy more effective, again in animals. Phase I trial of fasting and chemotherapy in human cancer patients nearly complete. (Source: EurekAlert! - Social and Behavioral Science)

Denis Parsons Burkitt CMG, MD, DSc, FRS, FRCS, FTCD (1911–93) Irish by birth, Trinity by the grace of God

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryDenis Parsons Burkitt, surgeon and research scientist, is a household name in the medical profession. Denis received his BA in 1933 and graduated as a physician in 1935 from Trinity College, Dublin. After serving as a surgeon in the Royal Army Medicine Corps during World War II, he worked as a surgeon and lecturer in Africa. It was in Africa that he developed exceptional observational and analytical skills, which led him to identify and formally develop a successful treatment for a childhood cancer that is now called Burkitt Lymphoma. The influence of Christianity in his life was huge. Throughout his life he remained extremely modest, attributing much of what he had achieved to the work of others. Denis's contributions to haemato‐oncology remain salient today, and his discoveries ...

Burkitt lymphoma in UGANDA, the legacy of Denis Burkitt and an update on the disease status

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryBurkitt lymphoma (BL) was first described in Uganda in 1958 as a sarcoma of the jaw but later confirmed to be a distinct form of Non Hodgkin lymphoma (NHL). This discovery was the defining moment of cancer research in Uganda, which eventually led to the establishment of a dedicated cancer research institute, the Uganda Cancer Institute (UCI) in 1967. The centre was dedicated to Denis Burkitt in recognition of his contribution to cancer research in East Africa. BL is still the commonest NHL in childhood in Uganda. Its incidence has significantly increased recently due to yet unknown factors. Although the human immunodeficiency virus (HIV) was considered a possible reason for the increase, there is no evidence that it has substantially impacted on the epidemiology of the disease. Howe...

Cancer and coagulation

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractThromboembolism, including both venous and arterial events, occurs commonly amongst patients with cancer. The occurrence of thromboembolism has significant consequences for cancer patients, including direct and indirect associations with mortality, morbidity, requirement for long‐term anticoagulant therapy and consumption of healthcare resources. Recent studies have resulted in a better understanding of clinical risk factors and biomarkers of cancer‐associated thrombosis, and a risk assessment model incorporating both has now been validated in multiple settings. Thromboprophylaxis with either unfractionated heparin or low‐molecular‐weight heparins (LMWHs) has been shown to be safe and effective in high‐risk settings such as hospitalization for medical illness and the post...

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

BioMed Central — Wed, 08 Feb 2012 05:00:00 +0100

Conclusions: Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells. (Source: BioMed Central)

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Brachytherapy reduces death in high-risk PCa patients

Modern Medicine — Wed, 08 Feb 2012 05:00:00 +0100

Brachytherapy alone, or in combination with external beam radiation therapy (EBRT), significantly reduces mortality rates in patients with high-risk prostate cancer, report the authors of a study from Thomas Jefferson University, Philadelphia. (Source: Modern Medicine)

5-ARI delays prostate cancer progression in men with low-risk disease

Modern Medicine — Wed, 08 Feb 2012 05:00:00 +0100

The 5-alpha-reductase inhibitor dutasteride (Avodart) appears to delay disease progression and the initiation of active treatment in men with low-risk, localized prostate cancer, results of a 3-year international clinical trial indicate. (Source: Modern Medicine)

Prognostic value of bcl-2 and bax tumor cell expression in patients with non muscle-invasive bladder cancer receiving bacillus calmette-guerin immunotherapy.

Ultrastructural Pathology — Wed, 08 Feb 2012 03:06:09 +0100

In conclusion, the expression of Bcl-2 and Bax in NMIBC could have a prognostic value in assessing the risk of recurrence after BCG immunotherapy. These findings require further investigations on larger cohort in order to ascertain new molecular markers of the response to BCG immunotherapy. PMID: 22292735 [PubMed - in process] (Source: Ultrastructural Pathology)

CT-based quantitative SPECT for the radionuclide (201)Tl: experimental validation and a standardized uptake value for brain tumour patients.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Willowson K, Bailey D, Schembri G, Baldock C Abstract We have previously reported on a method for reconstructing quantitative data from (99m)Tc single photon emission computed tomography (SPECT) images based on corrections derived from X-ray computed tomography, producing accurate results in both experimental and clinical studies. This has been extended for use with the radionuclide (201)Tl. Accuracy was evaluated with experimental phantom studies, including corrections for partial volume effects where necessary. The quantitative technique was used to derive standardized uptake values (SUVs) for (201)Tl evaluation of brain tumours. A preliminary study was performed on 26 patients using (201)Tl SPECT scans to assess residual tumour after surgery and then to monitor response...

Atypical lipomatous tumor with unusual extensive metaplastic ossification.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma. PMID: 22294061 [PubMed - in process] (Source: Cancer Imaging)

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The emergence of diagnostic imaging technologies in breast cancer: discovery, regulatory approval, reimbursement, and adoption in clinical guidelines.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Gold LS, Klein G, Carr L, Kessler L, Sullivan SD Abstract In this article, we trace the chronology of developments in breast imaging technologies that are used for diagnosis and staging of breast cancer, including mammography, ultrasonography, magnetic resonance imaging, computed tomography, and positron emission tomography. We explore factors that affected clinical acceptance and utilization of these technologies from discovery to clinical use, including milestones in peer-reviewed publication, US Food and Drug Administration approval, reimbursement by payers, and adoption into clinical guidelines. The factors driving utilization of new imaging technologies are mainly driven by regulatory approval and reimbursement by payers rather than evidence that they provide benefits...

Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Wagner T, Brechemier D, Dugert E, Le Guellec S, Julian A, Hitzel A, Beyne-Rauzy O Abstract A 71-year-old woman was admitted to our hospital with asthenia, weight loss, fever, cognitive impairment and shortness of breath. Physical examination showed hemiparesis and cerebellar ataxia. There was no superficial lymphadenopathy. Blood tests showed raised levels of C-reactive protein and lactate dehydrogenase. Bone marrow aspiration and biopsy were negative. [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) showed intense uptake within a right apical nodule and intense and diffuse uptake of FDG in the lungs without corresponding structural CT abnormality. Lung biopsy showed intravascular large B-cell lymphoma (IVLBCL). FDG-PET findings i...

Pilot study on evaluation of any correlation between MR perfusion (K(trans)) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Conclusion: We found that irrespective of brain tumor type, there is an inverse correlation between ADC and K(trans). Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition. PMID: 22275724 [PubMed - in process] (Source: Cancer Imaging)

Risk of Death From Certain Breast Cancers May Rise With Age

Cancercompass News: Breast Cancer — Wed, 08 Feb 2012 00:00:00 +0100

Research focused on estrogen-sensitive tumors; undertreatment might play a role, expert says (Source: Cancercompass News: Breast Cancer)

Komen official resigns over Planned Parenthood dispute

USATODAY.com Health — Tue, 07 Feb 2012 23:06:15 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

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Genetic Polymorphisms of FcγRIIa and FcγRIIIa Are Not Predictive of Clinical Outcomes after Cetuximab plus Irinotecan Chemotherapy in Patients with Metastatic Colorectal Cancer

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Oncology 2012;82:83-89 (DOI:10.1159/000335959) (Source: Karger Publishers)

Older Age Worsens Breast Cancer Prognosis (CME/CE)

MedPage Today State Required CME — Tue, 07 Feb 2012 22:13:11 +0100

(MedPage Today) -- Older age at diagnosis of postmenopausal, hormone receptor-positive breast cancer may independently worsen outcomes, researchers found. (Source: MedPage Today State Required CME)

Breast cancer kills older women more often

Reuters: Health — Tue, 07 Feb 2012 21:39:25 +0100

NEW YORK (Reuters Health) - Breast cancer is often considered more deadly among younger women, but a new study shows older women are actually more likely to die of the disease. (Source: Reuters: Health)

Breast Cancer Kills Older Women More Often

MedlinePlus Health News — Tue, 07 Feb 2012 21:39:22 +0100

Breast cancer is often considered more deadly among younger women, but a new study shows older women are actually more likely to die of the disease.Source: Reuters Health Related MedlinePlus Pages: Breast Cancer, Seniors' Health (Source: MedlinePlus Health News)

Komen VP quits after Planned Parenthood funds restored

bizjournals.com Health Care:Physician Practices headlines — Tue, 07 Feb 2012 21:26:50 +0100

Karen Handel, vice president for public policy of the Dallas-based Susan G. Komen for the Cure breast-cancer charity, has resigned in protest of the group's restoration of funding to Planned Parenthood, according to a Fox News report. In a letter, Handel said that she supported the charity's move last week to cut off funding to Planned Parenthood. The decision was later reversed after a firestorm of protest erupted across the nation. "I am deeply disappointed by the gross mischaracterizations of the strategy, its rationale, and my involvement in it,” Handel said in her letter... (Source: bizjournals.com Health Care:Physician Practices headlines)

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Ovarian Cancer Screening Common Despite Lack of Proof (CME/CE)

MedPage Today Public Health — Tue, 07 Feb 2012 18:44:38 +0100

(MedPage Today) -- More than 90% of primary care physicians reported ordering ovarian cancer screening tests not recommended for women with a low or average risk for the disease, a national survey showed. (Source: MedPage Today Public Health)

Komen Official Quits After Controversy

MedPage Today Public Health — Tue, 07 Feb 2012 18:23:16 +0100

(MedPage Today) -- A vice-president at the Susan G. Komen for the Cure Foundation has resigned in the wake of the controversy surrounding the organization's decision -- since reversed -- to stop funding Planned Parenthood's breast cancer programs. (Source: MedPage Today Public Health)

Roche breast cancer drug gets FDA priority review

Reuters: Health — Tue, 07 Feb 2012 18:15:26 +0100

(Reuters) - Health regulators granted a priority review for an experimental Roche breast cancer drug that in clinical trials added six months to the time before the disease worsened. (Source: Reuters: Health)

Breast Cancer Drug May Weaken Bones, Study Finds

The Doctors Lounge - Oncology — Tue, 07 Feb 2012 18:00:00 +0100

Researchers say postmenopausal women taking Aromasin need to be monitored (Source: The Doctors Lounge - Oncology)

Navigating Treatment Decisions

Kidney Cancer Association — Tue, 07 Feb 2012 17:54:52 +0100

This article focuses on treatment for clear cell disease, but some of these treatments are also appropriate for patients with non-clear cell disease. Some patients may have only a single metastatic tumor that can be removed by surgery. But most patients with metastatic disease have tumors in many parts of the body. In order to treat all of these tumors, patients are given systemic therapies, which are drugs that travel through the bloodstream and can directly reach cells throughout the body. Immunotherapy is a type of treatment that gives a boost to the immune system. The goal of immunotherapy is to help the patient’s immune system attack the cancer cells. Immunotherapy treatments have been available for decades and have generated renewed interest for treating metastatic RCC ...

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Well Blog: A Better Way to Spend Breast Cancer Funds?

NYT Health — Tue, 07 Feb 2012 17:43:25 +0100

We must move breast cancer advocacy to the next level, beyond screening for cancers that are already there, even beyond the cure, to finding the cause, writes Dr. Susan Love. (Source: NYT Health)

Breast Cancer Drug May Weaken Bones, Study Finds

MedlinePlus Health News — Tue, 07 Feb 2012 17:00:00 +0100

Researchers say postmenopausal women taking Aromasin need to be monitored Source: HealthDay Related MedlinePlus Pages: Bone Density, Breast Cancer, Drug Safety (Source: MedlinePlus Health News)

Quitting Smoking May Halve Risk of Oral Health Problems

MedlinePlus Health News — Tue, 07 Feb 2012 17:00:00 +0100

Smokers four times more likely to develop oral conditions, such as mouth cancers, gum disease, study finds Source: HealthDay Related MedlinePlus Pages: Gum Disease, Oral Cancer, Smoking (Source: MedlinePlus Health News)

Radioiodine Treatment of Metastatic Thyroid Cancer: Relative Efficacy and Side Effect Profile of Preparation by Thyroid Hormone Withdrawal Versus Recombinant Human Thyrotropin

Thyroid — Tue, 07 Feb 2012 16:53:26 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

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Komen VP steps down after Planned Parenthood flap

Reuters: Health — Tue, 07 Feb 2012 16:40:26 +0100

WASHINGTON (Reuters) - A senior executive of the breast cancer charity Susan G. Komen for the Cure has resigned after a public outcry over the group's decision to cut funding to women's health organization Planned Parenthood. (Source: Reuters: Health)

Komen official quits breast cancer charity over dispute

USATODAY.com Health — Tue, 07 Feb 2012 16:33:33 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

Komen official quits over Planned Parenthood

Health News: CBSNews.com — Tue, 07 Feb 2012 15:48:01 +0100

High-ranking official in breast-cancer charity resigns, saying she supported decision to pull Planned Parenthood funding (Source: Health News: CBSNews.com)

Official quits breast cancer charity over funding dispute

CTV Health — Tue, 07 Feb 2012 15:44:18 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the country's best-known family planning organization. The resignation came in a letter obtained by The Associated Press. (Source: CTV Health)

Official quits breast cancer charity over dispute

USATODAY.com Health — Tue, 07 Feb 2012 15:42:17 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

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What is Palliative Care?

Kidney Cancer Association — Tue, 07 Feb 2012 15:30:18 +0100

Dr. Robert Miller discusses the goals of palliative care and how it helps improve patients’ quality of life 02/08/2012 (Source: Kidney Cancer Association)

For physicians: VEGF tyrosine kinase inhibitor treatment risks

Kidney Cancer Association — Tue, 07 Feb 2012 15:22:50 +0100

A recent study led by scientists at Dana-Farber Cancer Institute found an slightly increased risk of fatal side effects in certain patients treated with VEGF-tyrosine kinase inhibitors. Dr. Toni Choueiri, who led the study, explains what physicians need to know about their patients' medical histories, and how they can help educate patients about the benefits and potential risks of these therapies. 02/08/2012 (Source: Kidney Cancer Association)

FDA grants priority review for HER-2—positive breast cancer treatment

HemOncToday.com — Tue, 07 Feb 2012 15:19:00 +0100

(Source: HemOncToday.com)

Live Kidney Cancer Chat on Tuesdays

Kidney Cancer Association — Tue, 07 Feb 2012 15:10:03 +0100

Join us for a live Facebook chat every Tuesday at 8 a.m. and 8 p.m. Central. The Kidney Cancer Association has more than 45,000 friends on Facebook and anyone interested in the eradication of death and suffering from this disease is welcome to join.02/07/2012 (Source: Kidney Cancer Association)

FDA questions Amgen drug for prostate cancer

USATODAY.com Health — Tue, 07 Feb 2012 14:15:14 +0100

The FDA will ask a panel of outside experts whether the benefits of Amgen's Xgeva outweigh its risks, which included bone disease. (Source: USATODAY.com Health)

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Expanded Palliative Care for All NSCLC PatientsExpanded Palliative Care for All NSCLC Patients

Medscape Today Headlines — Tue, 07 Feb 2012 13:45:52 +0100

An ASCO provisional clinical opinion recommends that all patients with metastatic nonsmall-cell lung cancer (NSCLC) be offered palliative care concurrent with standard therapy, starting at diagnosis. Medscape Medical News (Source: Medscape Today Headlines)

An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA Abstract Fallopian tube carcinoma (FTCA) is a very rare cancer type, but may be a useful platform for investigating high grade serous tumors of the pelvis that originate from a serous tubal intraepithelial carcinoma (STIC) precursor. Metastatic tumors from a patient diagnosed with Stage IIIC high grade serous FTCA (P0) were transplanted via intraperitoneal (IP) injection into a small cohort of mice (passage, P1). Patient information was obtained from the medical record. Tumors were grown, harvested and re-implanted or archived through P3. The P3 cohort was treated with saline (n=8) or cisplatin, 5 mg/kg (n=8), weekly for 4 weeks. After sacrifice, tumors from each passage and treatment group were passaged...

Benefit of Bone Drug in Prostate Cancer in Doubt

MedPage Today Public Health — Tue, 07 Feb 2012 13:00:00 +0100

WASHINGTON (MedPage Today) -- FDA reviewers have questioned whether expanding the indication for Amgen's denosumab (Xgeva) to prevent the spread of prostate cancer to the bones would provide much added benefit. (Source: MedPage Today Public Health)

News From The Journal Of Clinical Investigation: Feb. 6, 2012

Health News from Medical News Today — Tue, 07 Feb 2012 10:00:00 +0100

IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Muller, at the University of ZÃ¼rich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma... (Source: Health News from Medical News Today)

More Accurate Diagnosis Of Genetic Mutations Expected Using New Virtual Tool

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

DNA sequencing to detect genetic mutations can aid in the diagnosis and selection of treatment for cancer. Current methods of testing DNA samples, Sanger sequencing and pyrosequencing, occasionally produce complex results that can be difficult or impossible to interpret. Scientists at the Johns Hopkins University School of Medicine have developed a free software program, Pyromaker, that can more accurately identify such complex genetic mutations... (Source: Health News from Medical News Today)

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A Particular Breast Cancer Subtype May Respond To Drugs Targeting Chromosomal Instability

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson's Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of Cancer Biology, have shown in a study published online in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression... (Source: Health News from Medical News Today)

New Prostate Cancer Drug Target Identified

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. Dr. Liu and his team discovered a protein called ARD1 which is involved with the male hormone, androgen, and its receptor. Prostate cancer is a hormone-regulated disease and the main hormone is androgen... (Source: Health News from Medical News Today)

Increased Risk Of Fatal Side Effects From 3 'Targeted' Cancer Drugs

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Treatment with three relatively new "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber Cancer Institute. They added that the risk remains low, but should be taken into account by physicians and patients. The incidence of fatal complications was 1.5 percent in patients who received any of the three drugs, which block the vascular endothelial growth factor (VEGF) tyrosine kinase receptors in cancer cells, according to the study published February 6 in the Journal of Clinical Oncology... (Source: Health News from Medical News Today)

The final frontier in the war on cancer

Telegraph Health — Tue, 07 Feb 2012 08:28:48 +0100

Frustrated by glacial progress, the US has turned to physicists to fight the disease, reveals Paul Davies. (Source: Telegraph Health)

Oncology Translational Imaging For Early Phase Anticancer Drug Development - Conference, 14-15 March 2012, London

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Join SMi at their 8th annual Imaging in Cancer Drug Development conference to be held on the 14th & 15th March 2012 in London, that promises to be interactive and informative. With an increasing verity of imaging modalities available and each of them offering benefits at different stages and in different ways, there is a great deal of benefit that can be gained from their implementation... (Source: Health News from Medical News Today)

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Silver Compounds Found To Be Toxic To Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug - and may have fewer side-effects. Results from the study at the University of Leeds, published in Dalton Transactions, show that particular silver compounds are as toxic to cancer cells as the platinum-based drug Cisplatin, which is widely used to treat a range of cancers. But the crucial difference is that silver is thought to be much less toxic to healthy human cells, and in some cases, can be beneficial... (Source: Health News from Medical News Today)

Study Identifies Molecular Switch That Allows Melanoma To Resist Therapy

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma - the deadliest form of skin cancer - at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the molecular mechanisms underlying the development and progression of this disease in hopes of improving prevention and treatment strategies... (Source: Health News from Medical News Today)

'Biopsy In A Blood Test' - Effective New Diagnostic For Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Scientists from The Scripps Research Institute, Scripps Health, and collaborating cancer physicians have successfully demonstrated the effectiveness of an advanced blood test for detecting and analyzing circulating tumor cells (CTCs) - breakaway cells from patients' solid tumors - from cancer patients. The findings, reported in five new papers, show that the highly sensitive blood analysis provides information that may soon be comparable to that from some types of surgical biopsies... (Source: Health News from Medical News Today)

Breakthroughs Demonstrate Importance Of Targeted Therapies For Lung Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Different kinds of lung cancer behave in different ways, suggesting they are fundamentally different diseases. According to a University of Colorado Cancer Center study published in Cancer, the official journal of the American Cancer Society, different subgroups of non-small cell lung cancer (NSCLC) show distinct patterns of spread in the body... (Source: Health News from Medical News Today)

Reviewing Ways To Balance The Benefits Of Oxaliplatin With Its Side Effects When Treating Colon Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The drug oxaliplatin is a major reason the prognosis for metastatic colon cancer has gone from an expected survival of several months to a couple years. Unfortunately, the drug can also carry with it debilitating neurological side effects, which generally start as the sensation of pins and needles in fingers and toes and can leave patients unable to walk or dress independently... (Source: Health News from Medical News Today)

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No Breast Cancer Protections From Soy Isoflavone Supplements

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. Lead researcher Seema A. Khan, M.D., professor of surgery at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, said the results of this study are consistent with the findings of previous studies that were designed to test cancer prevention benefits of dietary supplements. "Simply put, supplements are not food... (Source: Health News from Medical News Today)

Health Highlights: Feb. 6, 2012

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Health Highlights: Feb. 6, 2012Category: Health NewsCreated: 2/6/2012 2:05:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Certain Cancer Drugs May Have Fatal Side Effects: Analysis

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Certain Cancer Drugs May Have Fatal Side Effects: AnalysisCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Antidepressants May Not Raise Suicide Risk in Youth: Study

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Antidepressants May Not Raise Suicide Risk in Youth: StudyCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Avoid Window Seats to Cut Risk for In-Flight Blood Clots: Study

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Avoid Window Seats to Cut Risk for In-Flight Blood Clots: StudyCategory: Health NewsCreated: 2/7/2012 10:05:00 AMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

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Certain Cancer Drugs May Have Fatal Side Effects: Analysis

MedicineNet Heart General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Certain Cancer Drugs May Have Fatal Side Effects: AnalysisCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Heart General)

UT MD Anderson, Texas A&M team up to treat canine lymphoma

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports. (Source: EurekAlert! - Medicine and Health)

Y-90: Are you ready? -- comprehensive liver tumor treatment course returns

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(Society of Interventional Radiology) Y-90: Are You Ready? -- an intensive course examining radiation biology, dosimetry, radiation safety, embolotherapy and clinical office management in the use of yttrium-90 in the treatment of cancer -- is being offered by the Society of Interventional Radiology Feb. 9-12 in Scottsdale, Ariz. The course is designed to provide focused educational opportunities for interventional radiologists, and SIR encourages fellows-in-training to attend. Limited spaces are still available. (Source: EurekAlert! - Medicine and Health)

Survey: Doctors Ignore Cancer Screening Guidelines?

Medical Headlines From Ivanhoe.com — Tue, 07 Feb 2012 05:00:00 +0100

(Ivanhoe Newswire) -- Recent clinical guidelines recommend against routine ovarian cancer screening because incidence of ovarian cancer is low, there is no proof that screening affects mortality rates, and screening tests have low positive predictive values and high false-positive rates. (Source: Medical Headlines From Ivanhoe.com)

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Researchers find ovarian cancer risk related to inherited inflammation genes

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(H. Lee Moffitt Cancer Center & Research Institute) In a study conducted by researchers at Moffitt Cancer Center and colleagues from 11 other institutions in the Unites States and the United Kingdom, genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer. (Source: EurekAlert! - Medicine and Health)

International scientific cooperation to advance image-guided prostate cancer care

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(American College of Radiology) To improve early diagnosis and treatment of prostate cancer, ACR, AdMeTech Foundation and ESUR have formed a joint effort to expedite development of standards for the Magnetic Resonance Prostate Imaging Reporting and Data System modeled after a successful effort in breast cancer care. The goal is to expedite the transfer of high-quality MRI from laboratories to patients to address the major need in prostate cancer care -- reducing unnecessary biopsies and treatment. (Source: EurekAlert! - Medicine and Health)

Risk of death from breast cancer higher among older patients

EurekAlert! - Social and Behavioral Science — Tue, 07 Feb 2012 05:00:00 +0100

(JAMA and Archives Journals) Among postmenopausal women with hormone receptor-positive breast cancer, increasing age was associated with a higher risk of death from breast cancer, according to a study in the Feb. 8 issue of JAMA. (Source: EurekAlert! - Social and Behavioral Science)

Salk scientists use an old theory to discover new targets in the fight against breast cancer

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(Salk Institute) Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer. (Source: EurekAlert! - Medicine and Health)

How early breast tumors become deadly: A small group of molecules might hold the answer

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(Ohio State University Medical Center) Researchers have discovered a pattern of molecules that differentiate early-stage breast tumors from invasive, life-threatening cancer. They also found a similar molecular signature that correlated with the aggressiveness of invasive tumors, and with the time to metastasis and overall survival. The findings could offer new strategies for treating breast cancer by blocking progression of early-stage breast cancer called ductal carcinoma in situ to life-threatening invasive cancer. (Source: EurekAlert! - Medicine and Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Initiating breast cancer by PIK3CA mutation

Breast Cancer Research — Tue, 07 Feb 2012 05:00:00 +0100

PIK3CA mutations confer constitutive activation of PI3K, which initiates intracellular kinase signaling cascades that promote cell proliferation and survival. Recent studies by Meyer et al. and Liu et al. demonstrate that expression of the H1047R exon 20 mutant of PIK3CA in luminal mammary epithelial cells induces tumorigenesis, implying that PIK3CA mutations are an early event in breast cancer. PIK3CA-H1047R-initiated tumors exhibit variable dependence on the oncogene, and variable sensitivity to PI3K inhibition. Amplification of the oncogenes MYC and MET was observed in tumors which recurred following silencing of PIK3CA-H1047R, suggesting that these pathways represent mechanisms of escape from PI3K inhibition. (Source: Breast Cancer Research)

Breast cancer risk prediction and individualised screening based on common genetic variation and breast density measurement

Breast Cancer Research — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Taken together, genetic risk factors and mammographic density offer moderate improvements to clinical risk factor models for predicting breast cancer. (Source: Breast Cancer Research)

Germline DNA copy number variation in familial and early-onset breast cancer

Breast Cancer Research — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: This is the first study to explore the contribution of germline CNVs to BRCA1/2 negative familial and early-onset breast cancer. The data suggest that rare CNVs may contribute to cancer predisposition in this small cohort of patients, and this trend needs to be confirmed in larger samples. (Source: Breast Cancer Research)

Contribution of CXCL12 secretion to invasion of breast cancer cells

Breast Cancer Research — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Expression of CXCL12 by tumor cells results in increased macrophage and microvessel density and in vivo invasiveness. (Source: Breast Cancer Research)

Self-Collection and HPV DNA Testing Could Be an Effective Cervical Cancer Screening Method

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

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Younger Breast Cancer Patients Have More Adverse Quality of Life Issues

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Is It Time to Introduce HPV Self-Sampling for Primary Cervical Cancer Screening?

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

CDC Launches Infection Awareness Initiative for Cancer Patients

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

New Data on Aspirin and Colorectal Cancer Brings Calls for New Guidelines, More Research

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Pooled Analysis of a Self-Sampling HPV DNA Test as a Cervical Cancer Primary Screening Method

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions The sensitivity of Self-HPV testing compared favorably with that of LBC and was superior to the sensitivity of VIA. Self-HPV testing may complement current screening programs by increasing population coverage in settings that do not have easy access to comprehensive cytology-based screening. (Source: JNCI)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion Monoclonal antibodies against HERV-K env protein show potential as novel immunotherapeutic agents for breast cancer therapy. (Source: JNCI)

Comparative Effectiveness of Oxaliplatin vs Non-Oxaliplatin-containing Adjuvant Chemotherapy for Stage III Colon Cancer

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion The addition of oxaliplatin to 5-FU appears to be associated with better survival among patients receiving adjuvant colon cancer treatment in the community. (Source: JNCI)

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions Not all mutant KRas proteins affect patient survival or downstream signaling in a similar way. The heterogeneous behavior of mutant KRas proteins implies that therapeutic interventions may need to take into account the specific mutant KRas expressed by the tumor. (Source: JNCI)

Re: Inconsistencies in Findings From the Early Lung Cancer Action Project Studies of Lung Cancer Screening

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

MedWorm: Inflammatory Breast Cancer

Personal Injury Suit Seeking Medical Monitoring For Cancer Removed In Louisiana

Fat injection reconstruction combo shows promise

FDA panel votes against wider use of Amgen drug

New treatment deep freezes ovarian tumors

Impact of early reoperation after resection for colorectal cancer on long‐term oncological outcomes

Short‐course preoperative radiotherapy prior to abdominoperineal resection for Stage I low rectal cancer; evidence based or defensive medicine?

Re: A proposal for the annotation of recurrent colorectal cancer

Outcome of right‐ and left‐sided colonic and rectal cancer following surgical resection Suttie SA, Shaikh I, Mullen R et al. Colorectal Dis 2011; 13: 884–9.

Adherence to national guidelines for surveillance after curative resection of nonmetastatic colon and rectum cancer: a survey among Norwegian gastrointestinal surgeons

Initial results of a randomized controlled trial comparing clinical and pathological downstaging of rectal cancer after preoperative short‐course radiotherapy or long‐term chemoradiotherapy, both with delayed surgery

Co‐publication agreement between Colorectal Disease and the Cochrane Colorectal Cancer Group

FDA Panel Turns Down Bone Drug in Prostate Ca

Fasting Might Boost Chemo's Cancer-Busting Properties

FDA Panel Votes Against Expanding Use of Amgen Drug Xgeva

Roche Breast Cancer Drug Gets FDA Priority ReviewRoche Breast Cancer Drug Gets FDA Priority Review

Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway

Breathalyzer Device Identifies Glucose Metabolism Problems Accurately

Soy Isoflavone Supplementation Not Effective In Breast Cancer Protection

Slow-Growing Prostate Cancer Is Still 'Real Cancer'Slow-Growing Prostate Cancer Is Still 'Real Cancer'

'Economy class' DVT syndrome myth busted

Insight: Komen charity under microscope for funding, science

Proton Therapy for Prostate Cancer: Benefits Overblown?Proton Therapy for Prostate Cancer: Benefits Overblown?

When Will This Woman Need Palliative Care?When Will This Woman Need Palliative Care?

Potential clinical applications of halichondrins in breast cancer and other neoplasms

Adjuvant Chemotherapy Slows Gastric CancerAdjuvant Chemotherapy Slows Gastric Cancer

Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Editorial Board

Contents

Repeat flexible sigmoidoscopy increases colorectal cancer detection rate

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

FDA Grants Imatinib (Gleevec) Full Approval for Adjuvant Treatment of GIST

The Great Prostate Debate: Does Screening Save Lives? (preview)

The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: Do liver metastases have a negative impact on survival?

Methyleseleninic acid downregulates aromatase

RSUME regulates VEGF-A in pituitary tumours

RSUMEs in pituitary adenomas

MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network

Leptin in Anorexia and Cachexia Syndrome

Targeting HLA class I expression to increase tumor immunogenicity

Three Florida hospitals collaborate to advance personalized medicine

The impact of lung cancer on patients and carers.

Key Finding In Stem Cell Self-Renewal

Early Signs Of Disease Detected By Metabolic 'Breathalyzer'

For Personalizing Cancer Therapy, Metabolic Profiles Are Essential

Women Born To Older Mothers Have A Higher Risk Of Developing Breast Cancer

Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments

Patient Sensitivity To Important Drug Target In Deadly Brain Cancer Predicted

More Accurate Diagnosis, Prognosis In Challenging Breast Cancer Cases Provided By PET Techniques

Breast cancer screening benefits are oversold and harms could be greater than thought

Men with low-risk prostate cancer may benefit from dutasteride, active surveillance

After Outcry, Karen Handel Resigns From Komen

Research partnership to improve treatments for cancer patients

Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

The role and function of cadherins in the mammary gland

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: A randomized controlled trial

Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation

basics of lymphedema

Top9ColCanRiskFactors

Personalizing Cancer Therapy

Heart disease may be a risk factor for prostate cancer

Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida

Moffitt Cancer Center teams with Ponce School of Medicine in Puerto Rico

London Cancer New Drugs Group Rapid Review:Erlotinib for the first-line treatment of advanced NSCLC with EGFR mutation

Potactasol 4mg powder for concentrate for solution for infusion (topotecan)- New Product

Horizon scanning: FDA Grants priority review of pertuzumab for untreated HER2-Positive metastatic breast cancer

Fasting weakens cancer in mice

Denis Parsons Burkitt CMG, MD, DSc, FRS, FRCS, FTCD (1911–93) Irish by birth, Trinity by the grace of God

Burkitt lymphoma in UGANDA, the legacy of Denis Burkitt and an update on the disease status

Cancer and coagulation

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

Brachytherapy reduces death in high-risk PCa patients

5-ARI delays prostate cancer progression in men with low-risk disease

Prognostic value of bcl-2 and bax tumor cell expression in patients with non muscle-invasive bladder cancer receiving bacillus calmette-guerin immunotherapy.

CT-based quantitative SPECT for the radionuclide (201)Tl: experimental validation and a standardized uptake value for brain tumour patients.

Atypical lipomatous tumor with unusual extensive metaplastic ossification.

The emergence of diagnostic imaging technologies in breast cancer: discovery, regulatory approval, reimbursement, and adoption in clinical guidelines.

Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs.

Pilot study on evaluation of any correlation between MR perfusion (K(trans)) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.

Risk of Death From Certain Breast Cancers May Rise With Age