MedWorm: Nonmelanoma Skin Cancer

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease

Annals of the Rheumatic Diseases — Mon, 25 Feb 2013 05:00:00 +0100

Conclusions Analysis of adverse events of interest through nearly 12 years of adalimumab exposure in clinical trials across indications demonstrated individual differences in rates by disease populations, no new safety signals and a safety profile consistent with known information about the anti-TNF class. (Source: Annals of the Rheumatic Diseases)

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Frequency and spectrum of metachronous malignancies in heart transplant recipients: a 11-year-experience at a German heart center.

International Journal of Clinical and Experimental Pathology — Thu, 21 Feb 2013 08:00:02 +0100

CONCLUSIONS: Incidence of various cancer types among HTX patients in this survey was consistent with previous studies, with lung and skin cancer as the commonest malignancies encountered. Regular cancer screening may be of benefit in reducing morbidity and mortality in these patients. PMID: 23412350 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

Development of a Plaque Infiltrated With Large CD30+ T Cells Over a Silicone-Containing Device in a Patient With History of Sezary Syndrome [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Fri, 15 Feb 2013 05:00:00 +0100

(Source: Journal of Clinical Oncology)

Pituitary tumor‐transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma

Experimental Dermatology — Fri, 15 Feb 2013 05:00:00 +0100

Abstract Nonmelanoma skin cancer is the most frequently‐occurring type of cancer worldwide and is caused by epidermal carcinogenesis and malignant progression that involve dysregulated expression of proto‐oncogenes and tumor suppressor genes. The proto‐oncogene pituitary tumor‐transforming gene 1 (PTTG1) is a ubiquitously expressed transcription factor that can promote enhanced proliferation of cultured epidermal keratinocytes. To the investigate the potential roles of PTTG1 in epidermal carcinogenesis and malignant progression, the expression of PTTG1 was analyzed by immunohistochemistry along with Ki67, keratin 10 (K10), and p53 in tissue samples of cutaneous squamous cell carcinomas (SCC), actinic keratoses (AK), and Bowen's disease (BD). Expression levels of PTTG1 were compared...

Use of Azathioprine for Non-Thymoma Myasthenia and Risk of Cancer: A Nationwide Case-Control Study in Denmark (P02.191)

Neurology — Thu, 14 Feb 2013 05:00:00 +0100

CONCLUSIONS: Use of azathioprine in non-thymoma MG patients may be associated with a slightly increased risk of overall cancer. Larger studies are warranted to address the risk of site specific cancers.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)

Increased Risk of Skin Cancer in Myasthenia Patients Treated with Azathioprine: A Nationwide Case-Control Study in Denmark (P02.192)

Neurology — Thu, 14 Feb 2013 05:00:00 +0100

CONCLUSIONS: Long-term use of azathioprine in MG patients increases the risk of NMSC.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Pottegaard has nothing to disclose. Dr. Hallas has received personal compensation for activities with the Association of Danish Pharmaceutical Industry. Dr. Friis has nothing to disclose. Dr. Hansen has received royalty payments from ThermoFisher Scientific. Dr. Jensen has nothing to disclose. Dr. Gaist has nothing to disclose. (Source: Neurology)

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Sunburn in children and adolescents: associations with parents' behaviour and attitudes.

Scandinavian Journal of Public Health — Thu, 07 Feb 2013 05:00:00 +0100

Conclusions: Interventions to influence the attitudes and behaviour of parents could reduce their children's risk for excessive sun exposure and thereby their risk for melanoma and non-melanoma skin cancer. The results encourage preventive campaigns to focus on changing parental attitudes towards tanned skin and sun behaviour. PMID: 23392996 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Public Health)

Patient‐reported outcome measures in nonmelanoma skin cancer of the face: a systematic review

British Journal of Dermatology — Wed, 06 Feb 2013 05:00:00 +0100

Summary Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient‐reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patients with NMSC for both the item formulation and subsequent validation. (Source: British Journal of Dermatology)

Patient-reported outcome measures in nonmelanoma skin cancer of the face: a systematic review.

The British Journal of Dermatology — Wed, 06 Feb 2013 05:00:00 +0100

Authors: Bates AS, Davis CR, Takwale A, Knepil GJ Abstract Nonmelanoma skin cancer (NMSC) is the most common malignancy in the western world, with an incidence of 98 000 in the U.K. Since 2009 the Department of Health (DoH) has collected patient-reported outcome measure (PROM) data following four common surgical procedures. However, a DoH PROM for NMSC does not exist. A systematic review of questionnaires published on patient concerns due to NMSC of the face was conducted. Keywords relevant to PROMs, NMSC and the facial region were comprehensively searched in medical databases. Inclusion criteria stipulated questionnaires from relevant papers that recruited patients with NMSC for both the item formulation and subsequent validation. PMID: 23387431 [PubMed - as supplied by publi...

Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma

Carcinogenesis — Tue, 05 Feb 2013 05:00:00 +0100

Ultraviolet B (UVB) light is the major environmental carcinogen contributing to non-melanoma skin cancer (NMSC) development. There are over 3.5 million NMSC diagnoses in two million patients annually, with men having a 3-fold greater incidence of squamous cell carcinoma (SCC) compared with women. Chronic inflammation has been linked to tumorigenesis, with a key role for the cyclooxygenase-2 (COX-2) enzyme. Diclofenac, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, currently is prescribed to patients as a short-term therapeutic agent to induce SCC precursor lesion regression. However, its efficacy as a preventative agent in patients without evidence of precursor lesions but with significant UVB-induced cutaneous damage has not been explored. We previously demonstrated in a muri...

Nonmelanoma Skin Cancer

Facial Plastic Surgery Clinics of North America — Thu, 31 Jan 2013 11:45:14 +0100

Nonmelanoma skin cancer (NMSC) is the most common form of malignancy in humans. The incidence of NMSC continues to increase despite increased awareness and sun-protective measures. If neglected or mismanaged, NMSC can cause significant morbidity and even death. The most common forms of NMSC on the head and neck include basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, eccrine porocarcinoma, Merkel cell carcinoma, atypical fibroxanthoma, and microcystic adnexal carcinoma. Surgery is the mainstay of treatment (standard excision, Mohs micrographic surgery, curettage); however, other modalities exist, including radiation, topical immunomodulators, photodynamic therapy, and new systemic medications. (Source: Facial Plastic Surgery Clinics of North America)

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HIV Patients At Two-Fold Higher Risk For Non-Melanoma Skin Cancers

Health News from Medical News Today — Thu, 31 Jan 2013 09:00:00 +0100

HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The study cohort of 6,560 HIV-positive and almost 37,000 HIV-negative subjects was drawn from members of Kaiser Permanente Northern California from 1996 to 2008. Overall, HIV-positive subjects had a 2... (Source: Health News from Medical News Today)

Cancer death rates are a third higher in men

NHS News Feed — Tue, 29 Jan 2013 11:20:00 +0100

The fact that men are more likely than women to both develop and die from cancer has been covered by most of the media today. The news is based on a report highlighting the excess cancer burden in men (both in terms of cases and deaths), and was produced by Cancer Research UK, the Men’s Health Forum and the National Cancer Intelligence Network. The results of the report were widely and accurately reported in the media. The report found that men are at significantly greater risk of both developing and dying from cancer, and the difference in risk increased further when breast and sex-specific cancers, for example cervical or prostate cancer, were excluded. The reasons for the increased risk in men compared to women are unknown. Biological differences between men and women may be part...

Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients

EurekAlert! - Medicine and Health — Tue, 29 Jan 2013 05:00:00 +0100

(Kaiser Permanente) HIV-positive patients have a higher incidence of non-melanoma skin cancers, according to a Kaiser Permanente study that appears in the current online issue of the Journal of the National Cancer Institute. Specifically, basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. (Source: EurekAlert! - Medicine and Health)

Effects of folic acid supplementation on overall and site-specific cancer incidence during randomised trials: meta-analyses of data on 50,000 individuals

NeLM - News — Fri, 25 Jan 2013 05:00:00 +0100

Source: Lancet Area: News Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. In The Lancet, researchers present new data that contribute to the debate regarding folic acid and cancer. They conducted a meta-analysis to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those for fortification. A search was conducted for trials completed before 2011 that compared folic acid with placebo, had scheduled treatment duration at least 1 year, included at least 500 participants, and recorded data on cancer incidence. Individual participant datasets that included 49,621 participants in all 13 such trials (10 trials ...

Nine out of 10 sunbeds have 'unsafe' UV levels

NHS News Feed — Thu, 17 Jan 2013 09:51:00 +0100

Conclusion This well-conducted and useful study suggests that, on average, the UV exposure from tanning units throughout England is higher than the recent standard level introduced throughout the EU, and that cancer risk from the average level of radiation seen across these units is more than twice that of the midday summer Mediterranean sun. The researchers say that there is a recent trend of increasing UV levels, and that this coincides "with the development of new high-power sunlamps". There are some discrepancies between the reporting of this research and the methods used in the study. Some newspapers reported the risk of skin cancer from sunbeds is twice as high as the Mediterranean sun, while others reported the risk as six times higher than natural sunlight. The headline...

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Nonmelanoma Skin Cancer Visits and Procedure Patterns in a Nationally Representative Sample: National Ambulatory Medical Care Survey 1995–2007

Dermatologic Surgery — Thu, 17 Jan 2013 05:00:00 +0100

ConclusionsNonmelanoma skin cancer visit rates increased from 1995 to 2007 and were higher in men than women. Visits to a dermatologist are more likely to be associated with a procedure for NMSC, and there may be discrepancies in treatment patterns based on insurance type and sex. (Source: Dermatologic Surgery)

Photodynamic Therapy in Mycosis Fungoides.

Actas Dermo-Sifiliograficas — Thu, 17 Jan 2013 05:00:00 +0100

This article reviews the literature and the practical application of photodynamic therapy in mycosis fungoides. PMID: 23332865 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Digital compression of facial arteries facilitates cutaneous nasal surgery.

The British Journal of Dermatology — Thu, 10 Jan 2013 05:00:00 +0100

Authors: Moran B, Foley C, Ormond P Abstract Non-melanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intra-operative bleeding (Fig. 1 (a)). Pinching the nasal tip to control bleeding is commonly used, however this can be uncomfortable for the patient because the nasal septum may not be anaesthetised (Fig. 1 (b)). PMID: 23301876 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from five years of follow-up.

The British Journal of Dermatology — Thu, 10 Jan 2013 05:00:00 +0100

CONCLUSIONS: No dose-related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to five years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate-to-severe psoriasis. PMID: 23301632 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

'Addressing' an under-recognised cause of discomfort for patients undergoing Mohs micrographic surgery.

The British Journal of Dermatology — Thu, 10 Jan 2013 05:00:00 +0100

Authors: Parker J, Norman D, Savage L, Hussain W Abstract Mohs micrographic surgery (MMS) is acknowledged as the gold-standard treatment for high risk non-melanoma skin cancer of the head and neck. By virtue of its tissue-sparing nature, patients who undergo MMS may require several stages or 'layers' to successfully extirpate a tumour. Under such circumstances it is commonplace for adhesive dressings to be applied between each stage to cover an exposed wound bed and act as a temporary pressure dressing to reduce the risk of bleeding. PMID: 23301598 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Risk Factors for Non-melanoma Skin Cancer in Kidney Transplant Patients in a Spanish Population in the Mediterranean Region.

Acta Dermato-Venereologica — Thu, 10 Jan 2013 05:00:00 +0100

Authors: García JB, Suárez-Varela MM, Vilata JJ, Marquina A, Pallardó L, Crespo J Abstract Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. A total of 289 patients who had received a kidney transplant during the period January 1996 to December 2010 were included in the study. Both prospective and retrospective data were used. All patients underwent a structured interview and a complete examination of the skin. After a median follow-up of 72 months (range 12-180 months), 73 of the 289 patient...

Long‐term safety of ustekinumab in patients with moderate‐to‐severe psoriasis: final results from 5 years of follow‐up

British Journal of Dermatology — Thu, 10 Jan 2013 05:00:00 +0100

ConclusionsNo dose‐related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to 5 years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate‐to‐severe psoriasis. (Source: British Journal of Dermatology)

Nonmelanoma skin cancer in Australia.

The British Journal of Dermatology — Tue, 01 Jan 2013 05:00:00 +0100

Authors: Sinclair R PMID: 23278555 [PubMed - in process] (Source: The British Journal of Dermatology)

Capecitabine to Reduce Nonmelanoma Skin Carcinoma Burden in Solid Organ Transplant Recipients

Dermatologic Surgery — Tue, 01 Jan 2013 05:00:00 +0100

ConclusionsSOTRs experienced a clinically and statistically significant decline in incident SCCs during treatment with low‐dose oral capecitabine, with varying degrees of side effects. Larger randomized trials will determine the dose and efficacy of capecitabine for adjuvant treatment of NMSC in SOTRs. (Source: Dermatologic Surgery)

Vitiligo: the white armor?

Pigment Cell Research — Tue, 01 Jan 2013 05:00:00 +0100

The difficulty in the management of the patient with vitiligo is that long‐term UVB narrowband phototherapy is the recognized mainstay for treatment contrasting with the fact that dermatologists warn constantly their patients about the dangers of sun exposure to limit skin aging and cancer. Ambivalent reasoning has not a great appeal in the profession and many dermatologists just prefer to give vitiligo patients sunscreens for white skin and advice for reinforced photoprotection. In this context, the retrospective study by Teulings et al. in a Dutch population indicating that patients with vitiligo have a decreased risk of developing melanoma and non melanoma skin cancer (NMSC) during their lifetime, and that phototherapy does not seem to increase that risk, could be seen as a positive r...

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Tumor necrosis factor α inhibitor therapy and cancer risk in chronic immune‐mediated diseases

Arthritis and Rheumatism — Thu, 27 Dec 2012 05:00:00 +0100

ConclusionShort‐term cancer risk was not elevated among patients treated with TNFα inhibitor therapy relative to commonly used therapies for immune‐ mediated chronic inflammatory diseases in this study. (Source: Arthritis and Rheumatism)

Incidence of Residual Nonmelanoma Skin Cancer in Excisions After Shave Biopsy

Dermatologic Surgery — Wed, 26 Dec 2012 05:00:00 +0100

ConclusionThe rate of residual nonmelanoma carcinoma in excision specimens after shave biopsy was found to be different from previously reported in the literature. These data may have therapeutic ramifications if further substantiated. (Source: Dermatologic Surgery)

Non-melanoma skin cancer in mouse and man.

Archives of Toxicology — Tue, 25 Dec 2012 05:00:00 +0100

Authors: Schwarz M, Münzel PA, Braeuning A Abstract As a frontier organ, skin is exposed to different environmental and/or occupational chemicals which cause cutaneous cancers in experimental animals. In mice, 7,12-dimethylbenz[a]anthrancene (DMBA) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) are frequently used as skin model tumor initiator and promoter, respectively. The sequential administration of DMBA and TPA leads to the appearance of a large number of benign papillomas, of which some convert later into invasive squamous cell carcinomas (SCC). At the molecular level, initiation of carcinogenesis in mouse skin consists in the mutational activation of the Ha-ras oncoprotein. HA-RAS mutations are rare in human SCC, but HA-RAS-mutated tumors appear in melanom...

Nonmelanoma skin cancer in Australia

British Journal of Dermatology — Fri, 21 Dec 2012 05:00:00 +0100

(Source: British Journal of Dermatology)

Weather conditions and daylight‐mediated photodynamic therapy: protoporphyrin IX‐weighted daylight doses measured in six geographical locations

British Journal of Dermatology — Fri, 21 Dec 2012 05:00:00 +0100

Conclusions Where and when to perform daylight‐PDT depends on the PpIX light dose and outdoor temperature. The PpIX light dose was influenced by the geographical location (latitude), weather condition and time of year. The UV index was not more suitable than temperature and weather to predict if the intensity of daylight would be sufficient for daylight‐PDT. (Source: British Journal of Dermatology)

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Are low levels of 25-hydroxyvitamin D a risk factor for cardiovascular diseases or malignancies in renal transplantation?

Nephrology Dialysis Transplantation — Thu, 20 Dec 2012 05:00:00 +0100

Conclusions Our data suggested that low vitamin D levels were not associated with an increased risk of cardiovascular diseases or malignancies. However, due to the small number of patients and events, the results should not be considered as definitive. Additional studies with a higher number of patients are required to elucidate the true impact of vitamin D status on cardiovascular and malignancy risks. (Source: Nephrology Dialysis Transplantation)

βKlotho regulates the differentiation and tumorgenesis of epidermal keratinocytes

Journal of Dermatological Science — Thu, 20 Dec 2012 05:00:00 +0100

klotho gene is a putative aging suppressor gene. Klotho protein exists in two forms: membrane Klotho and secreted Klotho. The secreted Klotho has been suggested to have anti-oxidative stress/anti-cancer properties partially by inhibiting type I insulin-like growth factor receptor (IGF-IR)/extracellular signal-regulated kinase (ERK) 1/2 activity in some human organs. βKlotho is a member of the Klotho protein family. Immunohistological analysis revealed that the expression of βKlotho protein was reduced in the lesion of human squamous cell carcinoma (SCC) and diminished in the lesion of basal cell carcinoma (BCC) compared to the non-lesional area of epidermis. The expression of βKlotho protein was markedly increased in the lesion of seborrheic keratoses (SK). In vitro experiments showed t...

Human papillomavirus infection in Bowen disease

Journal of Dermatological Science — Thu, 20 Dec 2012 05:00:00 +0100

Human papillomavirus (HPV) is one of the well-known risk factors of many epithelial malignancies of the oral cavity, larynx, and skin, as well as the cervix. Among the non-melanoma skin cancers, Bowen disease (BD) of the genitalia and fingers has been shown to be strongly linked to the high-risk types of HPV infection, especially HPV 16. Recently, there have been several case reports of HPV-associated BD on other locations as well; however, there are only several reports demonstrating the frequencies of HPV infection in BD lesions. The skin specimens of 142 BD lesions from 136 patients were investigated clinicopathologically. DNA extracted from fixed and embedded tissues was analyzed for the presence of mucous, high-risk types of HPV using polymerase chain reaction (PCR) in combination wit...

The long-term treatments of topical vitamin D3 inhibit the UV-induced skin tumor formation in a mouse model

Journal of Dermatological Science — Thu, 20 Dec 2012 05:00:00 +0100

In conclusion, topical calcitriol is more effective for tumor progression rather than tumor initiation and can be used as a chemopreventive agent, but it needs very careful approach because the adverse effects occur when the treated area is extensive. (Source: Journal of Dermatological Science)

Vitiligo lowers melanoma risk

Modern Medicine — Wed, 19 Dec 2012 05:00:00 +0100

Patients with vitiligo may have a lower risk for developing melanoma and nonmelanoma skin cancer, according to findings of a recent study. (Source: Modern Medicine)

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Pattern of HPV infection in basal cell carcinoma and in perilesional skin biopsies from immunocompetent patients

Virology Journal — Mon, 17 Dec 2012 05:00:00 +0100

Conclusions: These findings demonstrate that beta-HPV types belonging to species 1 are the most common HPV types detected in the skin of BCC patients. Moreover beta-1-HPV types and mixed infections are significantly more frequent in tumour samples than in healthy perilesional skin. Our results suggest that beta-1-HPVs as well as co-infection with more than one viral type could be important in NMSC and in particular in BCC.Further studies aimed to compare the biological activity of viral types in tumours and in healthy skin (viral replication and expression, interference of infection with cellular functions) are necessary to understand the role of HPV infection in skin cancer. (Source: Virology Journal)

Cyclo-oxygenase-2 inhibitors for chemoprevention of nonmelanoma skin cancer: Is there a role for these agents?

Journal of the American Academy of Dermatology — Thu, 13 Dec 2012 21:34:40 +0100

Selective cyclo-oxygenase (COX)-2 inhibitors have been proposed as potentially useful agents in the chemoprevention of nonmelanoma skin cancer (NMSC). Although COX-2 inhibitors are not without considerable risks, they may hold benefit for certain patient subgroups at risk for NMSC. In this article, we review studies examining the use of these agents in cancer prevention, and offer suggestions for future investigations with oral and topical COX-2 inhibitors in the prevention of NMSC. (Source: Journal of the American Academy of Dermatology)

Incidences of overall and site specific cancers in TNF{alpha} inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry

Annals of the Rheumatic Diseases — Wed, 12 Dec 2012 05:00:00 +0100

Conclusions Our results suggest that TNF-I therapy in routine care is not associated with an overall excess of cancer in arthritis patients, but observed increased risks of colon and ovarian cancer need further investigation. (Source: Annals of the Rheumatic Diseases)

[Risk of non-melanoma skin cancer under TNF inhibition : New aspects from the British Biologics Register.]

Zeitschrift fur Rheumatologie — Sun, 09 Dec 2012 05:00:00 +0100

[Risk of non-melanoma skin cancer under TNF inhibition : New aspects from the British Biologics Register.] Z Rheumatol. 2012 Dec 9; Authors: Zink A PMID: 23223913 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)

Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran.

Pathology, Research and Practice — Wed, 05 Dec 2012 05:00:00 +0100

Authors: Shayanfar N, Hosseini N, Panahi M, Azadmanesh K, Mohammadpour M, Kadivar M, Mirzaie AZ, Sohrabi A Abstract Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. The oncogenic role of human papilloma virus (HPV) in cutaneous SCC has been suggested by several studies performed on immunosuppresed patients. However, the role of mucosal type HPV in SCC patients with normal immunity has not been studied extensively. Sixty skin biopsies from immunocompetent SCC patients and 60 benign skin specimens were evaluated for mucosal type HPV DNA using polymerase chain reaction (PCR) and immunohistochemistry (IHC). Mucosal type HPV DNA was detected in 18 of 60 cases (30%) and in 7 of 60 controls (11.6%) using PCR. HPV immunostain was positive in 16 of 60 cases ...

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Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus.

Lupus — Tue, 04 Dec 2012 05:00:00 +0100

Authors: Wallace D, Navarra S, Petri M, Gallacher A, Thomas M, Furie R, Levy R, van Vollenhoven R, Cooper S, Zhong Z, Freimuth W, Cervera R, for the BLISS-52 and -76, and LBSL02 Study Groups Abstract Safety data were pooled and analyzed from one phase 2 and two phase 3 double-blind, placebo-controlled, repeat-dose systemic lupus erythematosus (SLE) trials of belimumab 1, 4 (phase 2 only), and 10 mg/kg. Types and rates of adverse events (AEs) were similar across treatment groups. Rates of patients experiencing any serious AE were 16.6%, 19.5%, 13.5%, and 18.0% with placebo, and belimumab 1, 4, and 10 mg/kg, respectively; rates of serious infusion reactions (including hypersensitivity reactions) occurring on the same days as infusions were 0.4%, 0.9%, 0%, and 0.9%, and rates of s...

A Collision of Diseases: Chronic Lymphocytic Leukemia Discovered During Lymph Node Biopsy for Melanoma

Annals of Surgical Oncology — Mon, 26 Nov 2012 16:19:12 +0100

Conclusions We have confirmed an increased association of CLL and melanoma. This may be related to an underlying immunologic defect; however, there has been scant investigation into this phenomenon. Surgeons and pathologists should understand this occurrence and recognize that not all grossly enlarged or abnormal sentinel lymph nodes in melanoma patients represent melanoma. Content Type Journal ArticleCategory MelanomasPages 1-5DOI 10.1245/s10434-012-2740-5Authors Jeffrey M. Farma, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAJonathan S. Zager, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USAVictor Barnica-elvir, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAChristopher A. Pule...

Reconstructing skin cancers using animal models

Cancer and Metastasis Reviews — Mon, 26 Nov 2012 00:28:27 +0100

Abstract The American Cancer Society estimates that skin cancer is the most prevalent of all cancers with over 2 million cases of nonmelanoma skin cancer each year and 75,000 melanoma cases in 2012. Representative animal cancer models are important for understanding the underlying molecular pathogenesis of these cancers and the development of novel targeted anticancer therapeutics. In this review, we will discuss some of the important animal models that have been useful to identify important pathways involved in basal cell carcinoma, squamous cell carcinoma, and melanoma. Content Type Journal ArticlePages 1-6DOI 10.1007/s10555-012-9410-8Authors Michael D. Gober, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 235a Clinical Research ...

The risk of developing non‐melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: a 10‐year, population‐based cohort study

International Journal of Dermatology — Wed, 21 Nov 2012 05:00:00 +0100

Conclusions Psoriasis carries an elevated risk of NMSC and lymphoma. This effect is modified by the severity of psoriasis, age, gender, and geographic location. (Source: International Journal of Dermatology)

Non-melanoma skin cancer in Australia.

Med J Aust — Mon, 19 Nov 2012 05:00:00 +0100

CONCLUSION: NMSC treatments increased by 86% between 1997 and 2010. We anticipate that the number and the total cost without inflation of NMSC treatments will increase by a further 22% between 2010 and 2015. NMSC will remain the most costly cancer and place an increasing burden on the Australian health care system. PMID: 23163687 [PubMed - in process] (Source: Med J Aust)

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Sensus Healthcare Announces Health Canada Approval

Medical Design Online News — Mon, 19 Nov 2012 03:39:44 +0100

Sensus Healthcare, providers of the SRT-100, the leading alternative for non surgical skin cancer treatment, announces that it has received a Medical Device License from Health Canada, permitting the marketing and sale of its device for treating skin cancer patients. The SRT-100™ is a state-of-the-art therapy device for Non Melanoma Skin Cancer (Source: Medical Design Online News)

Vitiligo patients have low risk for skin cancer

MedWire News - Dermatology — Sat, 17 Nov 2012 00:23:09 +0100

Evidence suggests that patients with vitiligo have a reduced risk for both melanoma and nonmelanoma skin cancer. (Source: MedWire News - Dermatology)

Pain and nonmelanoma skin cancer in transplant patients

Journal of the American Academy of Dermatology — Fri, 16 Nov 2012 05:54:51 +0100

To the Editor: Nonmelanoma skin cancer (NMSC) is the most common cancer in the United States. Approximately 80% of NMSCs are basal cell carcinomas (BCCs) and 20% are squamous-cell carcinomas (SCCs). Transplant patients are at an increased risk for developing numerous, frequently aggressive NMSCs. Considering that skin cancers are so frequent in this population, bedside tools to aid the physician in diagnosing these cancers would be of significant clinical utility. Thus the aim of the present study was to identify unique symptoms of NMSCs in this population. A striking finding of this analysis was the association of pain in skin cancers among transplant patients. (Source: Journal of the American Academy of Dermatology)

Skin Cancers And Sun Exposure

Health News from Medical News Today — Wed, 14 Nov 2012 09:00:00 +0100

Those individuals who work outdoors with resultant sun exposure are at increased risk for non-melanoma skin cancers, such as squamous cell carcinoma and basal cell carcinoma. Manige Fartasch shows that the connection between occupational UV exposure and squamous cell carcinoma is now well-established in her review article in issue 43 of Deutsches Arzteblatt International (Dtsch Arztebl Int 2012; 109(43): 715-20). The results are less clear for basal cell carcinoma, another form of non-melanoma skin cancer... (Source: Health News from Medical News Today)

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Place in the sun carries risks for outdoor workers

EurekAlert! - Medicine and Health — Mon, 12 Nov 2012 05:00:00 +0100

(Deutsches Aerzteblatt International) Those individuals who work outdoors with resultant sun exposure are at increased risk for non-melanoma skin cancers, such as squamous cell carcinoma and basal cell carcinoma. Manige Fartasch shows that the connection between occupational UV exposure and squamous cell carcinoma is now well-established in her review article in issue 43 of Deutsches Arzteblatt International. (Source: EurekAlert! - Medicine and Health)

Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey among 1307 patients and their partners.

The British Journal of Dermatology — Fri, 09 Nov 2012 05:00:00 +0100

Conclusions: Our findings suggest that patients with vitiligo have a decreased risk of both melanoma and NMSC. PMID: 23136900 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Is Tanning Bed Exposure Associated With Aggressive Basal Cell Carcinoma? [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Thu, 08 Nov 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

Brachytherapy Works in Skin Cancer (CME/CE)

MedPage Today Dermatology — Fri, 02 Nov 2012 12:43:04 +0100

BOSTON (MedPage Today) -- Researchers said here that nonmelanoma skin cancer can be easily removed using a form of electronic brachytherapy in a procedure that allows the physician to remain at the bedside while the device is operating. (Source: MedPage Today Dermatology)

Cancer risk in long‐term users of vitamin K antagonists: A population‐based case–control study

International Journal of Cancer — Fri, 02 Nov 2012 04:00:00 +0100

Abstract Some evidence suggests that long‐term use of vitamin K antagonists (VKAs) has a cancer chemopreventive effect. Such an effect would have considerable implications in terms of understanding tumor biology. To evaluate if long‐term VKA treatment influences the risk of developing cancer, we performed a matched case–control analysis. We used data from four Danish nationwide registers. Cases were all Danish individuals with a first‐time cancer diagnosis (except nonmelanoma skin cancer) between 2000 and 2009. For each case, eight controls, matched by birth year and gender, were selected from the source population by risk‐set sampling. Long‐term VKA use was defined as exposure to VKA for a period of 3 or more years. Conditional logistic regression was used to compute odds rati...

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Updated meta-analysis of non-melanoma skin cancer rates reported from prospective observational studies in patients treated with tumour necrosis factor inhibitors

Annals of the Rheumatic Diseases — Fri, 02 Nov 2012 04:00:00 +0100

We recently published a meta-analysis of malignancy rates reported from prospective observational studies in patients treated with tumour necrosis factor inhibitors (TNF-I).1 While there was no increase in the rates of all-site malignancy or lymphoma, there was an increased risk of non-melanoma skin cancer (NMSC) (1.45, 95% CI 1.15 to 1.76). The skin cancer analysis included data from an abstract from the British Society for Rheumatology Biologics Register (BSRBR)2 that has since been published as a full paper with different estimates.3 In the BSRBR abstract, the adjusted HR in comparison with a control cohort of patients treated with disease-modifying antirheumatic drugs, without a prior NMSC, was 1.7 (95% CI 0.9 to 3.4).2 The updated analysis provided separate estimates for basal c...

Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey among 1307 patients and their partners

British Journal of Dermatology — Thu, 01 Nov 2012 04:00:00 +0100

Conclusions: Our findings suggest that patients with vitiligo have a decreased risk of both melanoma and NMSC. (Source: British Journal of Dermatology)

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single‐ and Multicenter Retrospective Studies from 2006 to 2010

Dermatologic Surgery — Thu, 01 Nov 2012 04:00:00 +0100

ConclusionSun education programs and frequent screenings in organ transplant clinics have provided the best preventative strategies after transplantation, although the characteristics of the immunosuppressive regimen also play an important role. Thus, the adjuvant strategy of modifying immunosuppression may be effective when confronting severe transplant‐associated skin cancer. Although the decision‐making process for curbing levels of immunosuppression is difficult, further long‐term, randomized controlled studies should assess the effect of using less immunosuppressant medication while preserving graft function. (Source: Dermatologic Surgery)

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

Nature AOP — Wed, 31 Oct 2012 04:00:00 +0100

Nature advance online publication 31 October 2012. doi:10.1038/nature11624 Authors: Devarati Mitra, Xi Luo, Ann Morgan, Jin Wang, Mai P. Hoang, Jennifer Lo, Candace R. Guerrero, Jochen K. Lennerz, Martin C. Mihm, Jennifer A. Wargo, Kathleen C. Robinson, Suprabha P. Devi, Jillian C. Vanover, John A. D’Orazio, Martin McMahon, Marcus W. Bosenberg, Kevin M. Haigis, Daniel A. Haber, Yinsheng Wang & David E. Fisher People with pale skin, red hair, freckles and an inability to tan—the ‘red hair/fair skin’ phenotype—are at highest risk of developing melanoma, compared to all other pigmentation types. Genetically, this phenotype is frequently the product of inactivating polymorphisms in the melanocortin 1 receptor (MC1R) gene. MC1R encodes a cyclic AMP-stimulating...

Mobile telecommunications and health: report of an investigation into an alleged cancer cluster in Sandwell, West Midlands

The Journal of the Royal Society for the Promotion of Health — Tue, 30 Oct 2012 04:00:00 +0100

Conclusions: We cannot conclude that the base station was responsible for the cancers. It is unlikely that information around a single base station can either demonstrate or exclude causality. (Source: The Journal of the Royal Society for the Promotion of Health)

Multicenter Case-Control Study of Risk Factors for Cutaneous Melanoma in Valencia, Spain.

Actas Dermo-Sifiliograficas — Mon, 29 Oct 2012 04:00:00 +0100

CONCLUSIONS: Our study supports the importance of certain factors that indicate genetic predisposition (hair color and skin phototype) and environmental factors associated with exposure to sunlight. Patients with multiple acquired melanocytic nevi and patients with markers of chronic skin sun damage (actinic keratosis and nonmelanoma cancer) presented a significant increase in risk. PMID: 23117079 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

How Patterns, Timing Of Sunlight Exposure Contribute To Skin Cancers

Health News from Medical News Today — Thu, 25 Oct 2012 07:00:00 +0100

This study, published in the open-access journal BioMed Central, is the first case-control study to simultaneously evaluate identical patterns and timing of sunlight exposure as they are related to basal cell and squamous cell carcinomas in the same U.S... (Source: Health News from Medical News Today)

A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important.

Pigment Cell and Melanoma Research — Wed, 24 Oct 2012 04:00:00 +0100

Authors: Liu F, Bessonova L, Taylor TH, Ziogas A, Meyskens FL, Anton-Culver H Abstract Using US SEER17 Registry data, age-specific melanoma incidence rates were calculated and comparisons were made between males and females. Relative Risk (RR) for males and females in each age group were computed and compared to that from Nordic Cancer Registry dataset, and to that for non-melanoma skin cancer (NMSC). For age groups 44 and younger, females showed higher incidence rates, with a peak difference at age 20-24 (RR=2.01, 95% CI = 1.21 - 3.33). Males exhibited higher incidence rates after age 44. The same bimodal gender difference was confirmed by the Nordic Cancer Registry dataset, but it was not observed for NMSC, which is known to be strongly associated with cumulative exposure to sola...

How patterns and timing of sunlight exposure contribute to skin cancers

ScienceDaily Headlines — Tue, 23 Oct 2012 15:23:23 +0100

Researchers have studied the patterns and timing of sunlight exposure and how each is related to two nonmelanoma skin cancers – basal cell carcinoma and squamous cell carcinoma. (Source: ScienceDaily Headlines)

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Moffitt researchers study how patterns, timing of sunlight exposure contribute to skin cancers

EurekAlert! - Medicine and Health — Tue, 23 Oct 2012 04:00:00 +0100

(H. Lee Moffitt Cancer Center & Research Institute) Researchers at Moffitt Cancer Center, the University of South Florida and the International Agency for Research on Cancer in France have studied the patterns and timing of sunlight exposure and how each is related to two nonmelanoma skin cancers - basal cell carcinoma and squamous cell carcinoma. (Source: EurekAlert! - Medicine and Health)

Nonmelanoma Skin Cancer of the Head and Neck: Clinical Evaluation and Histopathology

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

Clinical and histopathologic features of nonmelanoma skin cancer, physical examination, and diagnostic methods (biopsy, dermoscopy, confocal microscopy) are summarized. A diagnostic algorithm provides a useful summarization of differential diagnosis of basal cell carcinoma, actinic keratosis, Bowen's disease, and squamous cell carcinoma. (Source: Facial Plastic Surgery Clinics of North America)

Nonmelanoma Skin Cancer of the Head and Neck: Molecular Mechanisms

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

This article presents a description of the effect on cells and impact on DNA of ultraviolet radiation, with a discussion of squamous cell and basal cell carcinoma in terms of the effects of genetic pathways and apoptosis. (Source: Facial Plastic Surgery Clinics of North America)

Nonmelanoma Skin Cancer of the Head and Neck: Nonsurgical Treatment

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

Nonmelanoma skin cancer (NMSC) is one of the most prevalent types of cancer worldwide, with basal cell carcinoma and squamous cell carcinoma being the most frequent histologic types. Surgical excision remains the mainstay of treatment, but nonsurgical treatment options may be indicated in specific cases. Nonsurgical treatment options for NMSC may be preferred as good alternatives under certain circumstances. This review provides a comprehensive overview of the nonsurgical treatment modalities for NMSCs, such as curettage and electrodesiccation, cryotherapy, radiotherapy, laser, photodynamic therapy, immunotherapy, and retinoid therapy. (Source: Facial Plastic Surgery Clinics of North America)

Nonmelanoma Skin Cancer of the Head and Neck: Surgical Treatment

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

This article focuses on the surgical treatment of nonmelanoma skin cancers of the head and neck. The risk factors of nonmelanoma skin cancers for recurrence and metastases that are important for choosing the best treatment option are summarized. Surgical treatment options including surgical excision with standard margins, frozen section, staged surgery, and Mohs micrographic surgery are described. Indications, techniques, outcomes, and advantages and disadvantages of each approach are reviewed. Finally, management of incomplete excisions is discussed. (Source: Facial Plastic Surgery Clinics of North America)

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Nonmelanoma Skin Cancer of the Head and Neck: Reconstruction

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

This article reviews the preoperative analysis of facial defects, and the major principles and techniques of facial reconstruction. Discussed are reconstruction of the nose, lip, cheek, forehead, and eyelid, presenting for each technique the goals of the reconstruction, types of flaps and grafts, and surgical technique. (Source: Facial Plastic Surgery Clinics of North America)

Nonmelanoma Skin Cancer of the Head and Neck: Prevention

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:14 +0100

The importance and effectiveness of prevention efforts and strategies for skin cancers are reviewed. Topical sunscreens and their proper use are presented. Topical and ingested forms of natural, synthetic, or biologic chemical agents that are potentially efficacious for chemoprevention are listtdldted and discussed. (Source: Facial Plastic Surgery Clinics of North America)

Nonmelanoma Skin Cancer of the Head and Neck

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:13 +0100

It has been a great honor for me to be a Guest Editor of this issue, entitled “Nonmelanoma Skin Cancer of the Head and Neck” in Facial Plastic Surgery Clinics of North America. Nonmelanoma skin cancers, especially basal cell carcinoma and squamous cell carcinoma, are the most common malignancies with involvement of the head and neck predominantly. Unfortunately, recent investigations and data have emerged indicating the rising incidence and morbidity of nonmelanoma skin cancers worldwide. As a matter of fact, different medical disciplines such as dermatology, otolaryngology, plastic surgery, radiology, and medical oncology all play a role in the diagnosis and medical and surgical treatment of nonmelanoma skin cancers. Therefore, the management of nonmelanoma skin cancers requires a mul...

Nonmelanoma Skin Cancer of the Head and Neck: Current Diagnosis and Treatment

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:13 +0100

An overview of where nonmelanoma cancers appear in the hierarchy of cancers is succinctly presented, as well as their incidence, etiology, and costs. The examination and treatment of these cancers are summarized. (Source: Facial Plastic Surgery Clinics of North America)

Epidemiology and Economic Burden of Nonmelanoma Skin Cancer

Facial Plastic Surgery Clinics of North America — Mon, 22 Oct 2012 23:10:13 +0100

The authors present a succinct summary of the incidence and costs of nonmelanoma skin cancers. They present incidence and health care costs for this disease from Australia, United States, and Europe, noting that NMSC care cost stands in fifth place after prostate, lung, colon, and breast carcinomas. (Source: Facial Plastic Surgery Clinics of North America)

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Multivitamins May Help Prevent Cancer

Mon, 22 Oct 2012 21:27:17 +0100

WebMD Medical News By Kathleen Doheny Reviewed by Louise Chang, MD Oct. 17, 2012 (Anaheim, Calif.) — Taking a daily multivitamin for years may lower the risk of cancer, according to new research. The study followed nearly 15,000 middle-aged and older men for about 11 years. It is not yet clear if the findings would apply to women or younger men. “The main findings were a reduction in total cancers of 8%,” says researcher J. Michael Gaziano, MD, MPH, a researcher at Brigham and Women’s Hospital and Harvard Medical School. ”Our main message is that the main reason to take a multivitamin is to prevent nutritional deficiency,” Gaziano said at a news briefing today at an American Association for Cancer Research meeting held here. “It appears there is a...

Light fractionated ALA-PDT enhances therapeutic efficacy in-vitro; the influence of PpIX concentration and illumination parameters

RSC - Photochem. Photobiol. Sci. latest articles — Sat, 20 Oct 2012 05:16:17 +0100

Photochem. Photobiol. Sci., 2012, Accepted ManuscriptDOI: 10.1039/C2PP25287B, CommunicationHenriette Suzanna de Bruijn, Adriana Gabriela Casas, Gabriela Di Venosa, Lautato Gandara, Henricus Johannes Sterenborg, Alcira Batlle, Dominic RobinsonLight fractionation, with a long dark interval, significantly increases the response to ALA-PDT in pre-clinical models and in non-melanoma skin cancer. We investigated if this increase in efficacy can be...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)

Multivitamins in the prevention of cancer in men: The Physicians' Health Study II RCT

NeLM - News — Thu, 18 Oct 2012 04:00:00 +0100

Source: JAMA Area: News This large-scale, randomised, double-blind, placebo-controlled trial (Physicians' Health Study II) has examined whether long-term multivitamin supplementation decreases the risk of total and site-specific cancer events among men. The study involved 14,641 male US physicians initially aged ?50 years (mean age, 64.3 years), including 1312 men with a history of cancer at randomisation, enrolled in 1997 with treatment and follow-up through to June 1, 2011. They received either daily multivitamin or placebo. The main outcome measures were total cancer (excluding non-melanoma skin cancer), with prostate, colorectal, and other site-specific cancers among the secondary end points. During a median follow-up of 11.2 years: . There were 2...

Risks for Skin Cancer Subclinical Extensions IdentifiedRisks for Skin Cancer Subclinical Extensions Identified

Medscape Today Headlines — Tue, 16 Oct 2012 17:47:23 +0100

Risk factors for the aggressive subclinical spread of nonmelanoma skin cancer include location, size, age, and immunosuppressed state, a new study finds. Medscape Medical News (Source: Medscape Today Headlines)

UK facing breast cancer 'timebomb'

NHS News Feed — Tue, 16 Oct 2012 11:13:00 +0100

Conclusion The current study gives projections for the number of cancer survivors in the UK between 2010 and 2040. As with all modelling studies, assumptions about what will happen in the future have to be made, and these assumptions may not prove to be correct. For example, events in the future may change these trends, such as new treatments or ways of screening for cancer, or changes in demographics. The authors of the current study acknowledge this uncertainty, and looked at the effect of using different assumptions on their predictions. The main results presented were based on the assumption that cancer trends would stay the same as they have in the past, which the authors note is simplistic, and perhaps optimistic in relation to increasing survival rates. However, they note that thi...

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Non-melanoma skin cancer: The hygiene hypothesis

Medical Hypotheses — Tue, 16 Oct 2012 04:00:00 +0100

Abstract: Protection against ultra violet radiation-induced DNA-damage in the skin is not only provided by the pigmentary system. The epidermal barrier consisting of stratum corneum keratinocytes, filaggrin and other proteins is an additional component of the UV-shield. Disruption of the epidermal barrier through frequent body cleansing with soaps and cosmetics may increase the risk of non-melanoma skin cancer. (Source: Medical Hypotheses)

Second Primary Malignancies after Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

Biology of Blood and Marrow Transplantation — Mon, 15 Oct 2012 04:00:00 +0100

Abstract: Recent studies demonstrate an increased risk of second primary malignancies (SPMs) in patients with multiple myeloma (MM) receiving maintenance lenalidomide after autologous stem cell transplantation (ASCT). We explored the possibility of other risk factors driving post-ASCT SPMs in patients with MM through analysis of our large transplantation database in conjunction with our Long-Term Follow-Up Program. We conducted a retrospective cohort study of 841 consecutive patients with MM who underwent ASCT at City of Hope between 1989 and 2009, as well as a nested case-control analysis evaluating the role of all therapeutic exposures before, during, and after ASCT. Median duration of follow-up for the entire cohort was 3.4 years (range, 0.3-19.9 years). Sixty cases with a total of 70 S...

Skin carotenoid levels are not associated with risk of nonmelanoma skin cancer: Response to “Supplement use and the risk of cutaneous squamous cell carcinoma”

Journal of the American Academy of Dermatology — Sat, 13 Oct 2012 01:24:10 +0100

To the Editor: Carotenoids, vitamin A provitamins found in several foods and oral supplements, have antioxidant and photoprotective properties and may confer protection against nonmelanoma skin cancer with less associated toxicity than systemic retinoids. However, study findings to date, including those of the study “Supplement use and the risk of cutaneous squamous cell carcinoma”, have failed to provide strong evidence for the anticancer effects of these chemical compounds. (Source: Journal of the American Academy of Dermatology)

Skin carotenoid levels may not reflect vitamin A (retinol) levels

Journal of the American Academy of Dermatology — Sat, 13 Oct 2012 01:24:10 +0100

To the Editor: We read with interest the letter entitled “Skin carotenoid levels are not associated with risk of nonmelanoma skin cancer.” The goal of this small pilot study was to compare mean skin carotenoid levels among 23 patients with a history of basal cell carcinoma (BCC), 22 patients with a history of squamous cell carcinoma (SCC), and 36 patients with no nonmelanoma skin cancer (NMSC) history, and the differences were not found to be statistically significant. Whereas the lack of statistical significance may be due to the lack of power in the study (as mentioned by the authors), as well as other methodologic issues (no adjustment for potential confounding variables such as age, gender, and ethnicity which may impact risk of BCC, SCC, and skin carotenoid levels; no informati...

Tumor necrosis factor alpha inhibitor therapy and cancer risk in chronic immune mediated diseases

Arthritis and Rheumatism — Wed, 10 Oct 2012 04:00:00 +0100

Conclusions:Short‐term cancer risk was not elevated among patients treated with TNF‐I therapy relative to commonly used therapies for immune mediated chronic inflammatory diseases in this study. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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Indoor tanning boosts NMSC risk

Modern Medicine — Wed, 10 Oct 2012 04:00:00 +0100

Indoor tanning significantly increases the risk of contracting nonmelanoma skin cancer (NMSC), especially in those under age 25, a new study confirms. (Source: Modern Medicine)

Actinic keratosis in the en‐face and slice imaging mode of high‐definition optical coherence tomography and comparison with histology

British Journal of Dermatology — Fri, 05 Oct 2012 04:00:00 +0100

Conclusions HD‐OCT with both the en‐face and slice imaging modes offers additional information in the diagnosis of AK compared with conventional OCT and might enhance the possibility of the noninvasive diagnosis of AK prior to treatment procedures and possibly in the monitoring of noninvasive treatment strategies. (Source: British Journal of Dermatology)

Role of Pain Medications, Consultants, and Other Services in Improved Pain Control of Elderly Adults with Cancer in Geriatric Evaluation and Management Units

Journal of the American Geriatrics Society — Thu, 04 Oct 2012 04:00:00 +0100

ConclusionSignificantly greater use of psychology, psychiatry, physical and occupational therapy in the GEMU participants may have improved the effectiveness of pain management in individuals in inpatient GEMUs. Although analgesic use was not significantly different between the GEMU and usual care groups, small sample size may have limited the ability to detect these differences. (Source: Journal of the American Geriatrics Society)

Study: Tanning beds cause 170K skin cancer cases yearly

Health News: CBSNews.com — Wed, 03 Oct 2012 14:38:36 +0100

Non-melanoma skin cancers most common form of cancer in U.S., with 2 million new cases annually (Source: Health News: CBSNews.com)

Non-melanoma skin cancer sunbed risk

NHS News Feed — Wed, 03 Oct 2012 09:53:00 +0100

Conclusion This is a well conducted systematic review that provides evidence that indoor tanning is associated with increased risk of the non-melanoma skin cancers, basal cell and squamous cell carcinoma. As UV light exposure is already known to be the strongest risk factor for these cancers, as well as the more aggressive malignant melanoma, this finding is hardly surprising. As the researchers point out, their review only included observational studies and so cannot prove that sunbed use caused the development of non-melanoma skin cancers. Observational studies (as opposed to randomised controlled trials) may be affected by other factors, called confounders, which affect the reliability of the results. For example, people who use sunbeds might have other lifestyle factors that increase t...

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Cancer incidence in UK electricity generation and transmission workers, 1973-2008

Occupational Medicine — Wed, 03 Oct 2012 04:00:00 +0100

Conclusions The clear occupational excess of mesothelioma was not matched by a corresponding excess of lung cancer, and the level of asbestos-induced lung cancer in this industry must be low. Leukaemia risks declined with period from hire; confident interpretation of this finding is not possible. The excesses of cancers of the nasal cavities and small intestine are probably not occupational, though the excess of skin cancer may be due to outdoor work. (Source: Occupational Medicine)

Study Affirms Indoor Tanning, Skin Cancer Link (CME/CE)

MedPage Today Dermatology — Wed, 03 Oct 2012 03:13:02 +0100

(MedPage Today) -- Indoor tanning with lamps and beds boosts the risk of nonmelanoma skin cancer, especially among younger people, a meta-analysis suggested. (Source: MedPage Today Dermatology)

Indoor Tanning Beds Linked to Common Skin Cancers

WebMD Health — Tue, 02 Oct 2012 05:00:00 +0100

Indoor tanning beds may raise the risk of non-melanoma skin cancers, especially among people who start tanning before they turn 25, a new study suggests. (Source: WebMD Health)

Tanning beds linked to non-melanoma skin cancer

EurekAlert! - Cancer — Tue, 02 Oct 2012 04:00:00 +0100

(University of California - San Francisco) Indoor tanning beds can cause non-melanoma skin cancer -- and the risk is greater the earlier one starts tanning, according to a new analysis led by UCSF. (Source: EurekAlert! - Cancer)

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Association between multiple cutaneous melanoma and other primary neoplasms

Clinical And Experimental Dermatology — Mon, 01 Oct 2012 04:00:00 +0100

Conclusions. Patients with MPM, especially men with skin phototype II, have a significantly increased incidence of developing SPC, particularly NMSC. Thus, careful monitoring is essential not only to detect recurrence of the original cancer or development of another primary melanoma, but also development of new malignancies of different types, particularly NMSC. (Source: Clinical And Experimental Dermatology)

In Vivo Reflectance Confocal Microscopy of Basal Cell Carcinoma: Feasibility of Preoperative Mapping of Cancer Margins

Dermatologic Surgery — Mon, 01 Oct 2012 04:00:00 +0100

ConclusionRCM imaging of the margins is feasible and demonstrates the possibility of preoperative mapping of cancer margins. (Source: Dermatologic Surgery)

Infliximab for Crohn’s Disease: The First 500 Patients Followed Up Through 2009

Digestive Diseases and Sciences — Fri, 28 Sep 2012 15:57:43 +0100

Conclusions Long-term follow-up of patients with Crohn’s disease who were treated with infliximab initially between 1998 and 2002 showed persistence of therapy (due to clinical benefit) and an acceptable safety profile, despite the fact that less than one-third initially received three-dose induction followed by scheduled maintenance therapy. Infections and malignancy occurred at rates similar to those previously reported. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s10620-012-2405-zAuthors Jennifer L. Seminerio, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN 55905, USAEdward V. Loftus Jr., Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, MN...

Limitations in health care access and utilization among long‐term survivors of adolescent and young adult cancer

Cancer — Mon, 24 Sep 2012 17:13:22 +0100

CONCLUSIONS:AYA cancer survivors may forgo health care due to cost barriers, potentially inhibiting the early detection of late effects. Expanding health insurance coverage for young cancer survivors may be insufficient without adequate strategies to reduce their medical cost burdens. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer)

Hypericin-PDT induced rapid, necrotic cell death in human squamous cell carcinoma cultures after multiple treatments.

Cell Biology International — Mon, 24 Sep 2012 04:00:00 +0100

This study proposes a novel "double-hit/2-day" strategy to reduce the viability in squamous cell carcinomas using hypericin-based PDT as an adjunctive treatment modality. PMID: 23005701 [PubMed - as supplied by publisher] (Source: Cell Biology International)

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High incidence of skin cancer in the Channel Islands

Clinical And Experimental Dermatology — Mon, 24 Sep 2012 04:00:00 +0100

Conclusions. This study indicates that the Channel Islands have a high incidence of skin cancer (both MM and NMSC). In addition, the data show that the ASRs in older people in this population group differ from those in mainland UK, showing higher rates in the over 65 years age group. (Source: Clinical And Experimental Dermatology)

Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin -- a case--control study

BMC Cancer — Thu, 20 Sep 2012 04:00:00 +0100

Conclusions: Results from the current study suggest that sunlight exposure is associated with both BCC and SCC risk regardless of the pattern in which the exposure was received (i.e. intermittent vs. continuous). The data also suggest that sunlight exposure at a younger age may be more important for SCC but not BCC, however additional studies are needed to further characterize sunlight exposure-response relationships in different types of NMSC. (Source: BMC Cancer)

Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions Optical and Terahertz skin cancers imaging

Journal of Biophotonics — Fri, 14 Sep 2012 04:00:00 +0100

Abstract We tested the hypothesis that polarization sensitive optical and terahertz imaging may be combined for accurate nonmelanoma skin cancer (NMSC) delineation. Nine NMSC specimens were imaged. 513 μm and 440 nm wavelengths were used for terahertz and optical imaging, respectively. Histopathology was processed for evaluation. Terahertz reflectance of NMSC was quantified. Our results demonstrate that cross‐polarized terahertz images correctly identified location of the tumours, whereas cross‐polarized and polarization difference optical images accurately presented morphological features. Cross‐polarized terahertz images exhibited lower reflectivity values in cancer as compared to normal tissue. Combination of optical and terahertz imaging shows promise for intraoperative delineat...

HGF in the Neighborhood Reverses Resistance to BRAF inhibitor in Melanoma.

Pigment Cell and Melanoma Research — Thu, 13 Sep 2012 04:00:00 +0100

Authors: Nickoloff BJ, Woude GV Abstract Most anti-cancer chemotherapeutic agents used in the clinic have been selected to directly target tumor cells, but growing evidence indicates targeting non-tumor cells in the surrounding microenvironment such as stromal fibroblasts may soon pay clinical dividends. While the treatment of metastatic melanoma has evolved and been revolutionized by targeted therapy (Drake, 2011; Retsas, 2011), Straussman et al. demonstrate stromal fibroblast secreted HGF is a significant candidate for overcoming drug resistance in the setting of BRAF-mutant melanoma (Straussman et al., 2012). As if cancer cell-based molecular interactions and pathway feedback loops amongst the members of the RAS/RAF family either with or without oncogenic mutations and/or target...

Risk of second primary malignancies in women with cervical cancer: A population-based study in Taiwan over a 30-year period.

Gynecologic Oncology — Mon, 10 Sep 2012 04:00:00 +0100

CONCLUSIONS: SIR for second cancers was significantly greater than the general population in cervical cancer patients. A young age at the diagnosis of cervical cancer predicted an increased risk. The second cancers worsened overall survival. PMID: 22975362 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Clinical Value of Paraffin Sections in Association with Mohs Micrographic Surgery for Nonmelanoma Skin Cancers

Dermatologic Surgery — Fri, 07 Sep 2012 04:00:00 +0100

ConclusionIn MMS for select high‐risk or unusual nonmelanoma skin cancers, paraffin sections are useful in more accurately documenting tumor histology, completing cutaneous squamous cell carcinoma staging, and detecting PNI. (Source: Dermatologic Surgery)

Marriage and divorce among young adult cancer survivors

Journal of Cancer Survivorship — Wed, 05 Sep 2012 17:02:39 +0100

Conclusions The emotional and financial burdens of cancer may lead to marital stress for younger cancer survivors. Implications for cancer survivors Young survivors may face a higher risk of divorce; support systems are needed to assist them in the years following diagnosis. Content Type Journal ArticlePages 1-10DOI 10.1007/s11764-012-0238-6Authors Anne C. Kirchhoff, Center for Children’s Cancer Research, Huntsman Cancer Institute, Salt Lake City, UT, USAJaehee Yi, Cancer Control and Population Sciences Research Program, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USAJennifer Wright, Center for Children’s Cancer Research, Huntsman Cancer Institute, Salt Lake City, UT, USAEcho L. Warner, Cancer Control and Population Sc...

Could We Be Missing Skin Cancer in IBD Patients?Could We Be Missing Skin Cancer in IBD Patients?

Medscape Today Headlines — Tue, 04 Sep 2012 15:52:50 +0100

Dr. David Johnson offers commentary on the evolving data regarding the risk of melanoma and nonmelanoma skin cancer in patients with inflammatory bowel disease, and how medication may play a role. Medscape Gastroenterology (Source: Medscape Today Headlines)

Nonmelanoma Skin Cancer

The Journal for Nurse Practitioners — Sat, 01 Sep 2012 04:00:00 +0100

(Source: The Journal for Nurse Practitioners)

miR-31/FIH-1 in keratinocyte differentiation [Cell Biology]

Proceedings of the National Academy of Sciences — Tue, 28 Aug 2012 04:00:00 +0100

Notch plays a critical role in the transition from proliferation to differentiation in the epidermis and corneal epithelium. Furthermore, aberrant Notch signaling is a feature of diseases like psoriasis, eczema, nonmelanoma skin cancer, and melanoma where differentiation and proliferation are impaired. Whereas much is known about the downstream events following... (Source: Proceedings of the National Academy of Sciences)

Risk of malignancy in children with juvenile idiopathic arthritis not treated with biologic agents

Arthritis Care and Research — Mon, 27 Aug 2012 04:00:00 +0100

ConclusionWe found a nearly 3‐fold increased risk of cancer in biologics‐naive JIA patients, which approached significance despite the small number of outcomes. This finding suggests an elevated underlying risk of cancer in this disease population. (Source: Arthritis Care and Research)

[Fluorescence diagnosis of non-melanoma skin cancer].

Orvosi Hetilap — Sun, 26 Aug 2012 04:00:00 +0100

Authors: Gaál M, Kui R, Hunyadi Z, Kemény L, Gyulai R Abstract Photodynamic therapy involves - in dermatological practice usually exogenous - application of a photosensitizer then activation of accumulated protoporphyrin IX by light with an appropriate wavelength after a short incubation period. It is an evidence based method to treat certain non-melanoma skin cancers. During treatment when the excited protoporphyrin IX returns to base state, reactive oxygen species are formed leading to cell death in rapidly proliferating cells. Fluorescence of excited protoporphyrin IX can be used in diagnostics as well. In ultraviolet light, the photodamaged or neoplastic areas show coral red fluorescence which can clearly be distinguished from the much lower fluorescence of adjacent normal ti...

A Population-based Study of DNA Repair Gene Variants in Relation to Non-melanoma Skin Cancer as a Marker of a Cancer-prone Phenotype

Carcinogenesis — Thu, 23 Aug 2012 04:00:00 +0100

For unknown reasons, non-melanoma skin cancer (NMSC) is associated with increased risk of other malignancies. Focusing solely on DNA repair or DNA repair-related genes, this study tested the hypothesis that DNA repair gene variants contribute to the increased cancer risk associated with a personal history of NMSC. From the parent CLUE II cohort study, established in 1989 in Washington County, MD, the study consisted of a cancer-free control group (n 5 2296) compared with three mutually exclusive groups of cancer cases ascertained through 2007: (i) Other (non-NMSC) cancer only (n 5 2349); (ii) NMSC only (n 5 694) and (iii) NMSC plus other cancer (n 5 577). The frequency of minor alleles in 759 DNA repair gene single nucleotide polymorphisms (SNPs) was compared in these four groups. Comparin...

Review: Facial basal cell carcinoma

NeLM - News — Thu, 23 Aug 2012 04:00:00 +0100

Source: BMJ Area: News Basal cell carcinoma (BCC) is a locally invasive cancer of epidermal basaloid cells and is the most common cancer in humans. Skin cancers are categorised into two groups-melanomas and non-melanoma skin cancers. Of the non-melanoma skin cancers, 75-80% are BCCs and up to 85% of these are on the head and neck. This review focuses on the diagnosis, investigation, and management of BCC of the head and neck. Topics discussed include: . Who gets BCC? . Risk factors . How do BCCs present? . How are BCCs diagnosed? . What does a BCC look like histologically? . What is high risk BCC? . What are the treatment options for BCC? (wide local excision, mohs micrographic surgery, radiotherapy, photodynamic therapy...

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Over-65s with cancer 'set to triple by 2040'

NHS News Feed — Mon, 20 Aug 2012 12:00:00 +0100

Conclusion This sort of study can provide useful projections of the expected number of people set to be living with cancer by 2040. However, it is important to note that the figures are only predictions and have been calculated based on estimates and assumptions. For example, the first model has assumed that future rates of new cancer, improvement in detection rates from screening and improved survival from new treatments will continue past 2009 at the same rate. However, for long-term projections such as this there are many unknowns. For a start, advances in medicine that led to higher survival rates for most types of cancer may not continue in the same way for another 30 years. Furthermore, the introduction of population screening programmes may cause increases in recorded cancer inciden...

Efficacy, safety and medication cost implications of adalimumab 40 mg weekly dosing in patients with psoriasis with suboptimal response to 40 mg every other week dosing: results from an open‐label study

British Journal of Dermatology — Mon, 20 Aug 2012 04:00:00 +0100

Conclusions Most patients did not require dose escalation. By 12 weeks after dose escalation, one‐quarter achieved substantial clinical improvement. Safety results were similar between patients who dosage‐escalated and those who did not. (Source: British Journal of Dermatology)

Contralateral distribution of Nonmelanoma Skin Cancer between older Hispanic/Latino and Non‐Hispanic/Non‐Latino Individuals

British Journal of Dermatology — Thu, 16 Aug 2012 04:00:00 +0100

Conclusion: Nonmelanoma skin cancer appears to be more common on the left side of older, Non‐Hispanic/Non‐Latino individuals, while it is more common on the right side of older, Hispanic/Latino individuals; likely secondary to an environmental factor, such as ultraviolet radiation. Nonmelanoma skin cancer is significantly more common in males relative to females, which may be attributed to differences in gender roles or referral practices. (Source: British Journal of Dermatology)

Contralateral distribution of Nonmelanoma Skin Cancer between older Hispanic/Latino and Non-Hispanic/Non-Latino Individuals.

The British Journal of Dermatology — Thu, 16 Aug 2012 04:00:00 +0100

Conclusion: Nonmelanoma skin cancer appears to be more common on the left side of older, Non-Hispanic/Non-Latino individuals, while it is more common on the right side of older, Hispanic/Latino individuals; likely secondary to an environmental factor, such as ultraviolet radiation. Nonmelanoma skin cancer is significantly more common in males relative to females, which may be attributed to differences in gender roles or referral practices. PMID: 22897506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Skin Cancer Patients Should Be Screened Before Receiving Vemurafenib

Health News from Medical News Today — Wed, 15 Aug 2012 17:00:00 +0100

According to a study conducted by Cancer Research UK, different genetic mutations powering skin cancer may have an impact on how patients respond to the drug vemurafenib, meaning that individuals suffering from melanoma skin cancer should be screened prior to treatment. The team found that certain rare gene mutations in the tumors of patients receiving the drug may also explain why some patients go on to develop secondary non-melanoma skin cancers. The study is published in the journal Genes and Development. The drug targets a common defect in the gene BRAF, called V600E... (Source: Health News from Medical News Today)

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Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects

Archives of Dermatological Research — Tue, 14 Aug 2012 16:56:19 +0100

Abstract Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive. To assess the association between rs401681[C] allele and NMSC risk, we performed this meta-analysis with four case–control studies involving 5,469 cases and 39,715 controls. Our meta-analysis showed that rs401681[C] allele was associated with NMSC susceptibility in the overall subjects (C vs. T, OR 1.13, 95 % CI 1.07–1.20). In the stratified analysis, the rs401681[C] allele confers susceptibility in Icelanders (C vs. T, OR 1.15, 95 % CI 1.06–1.26) and non-Icelanders (C vs. T, OR 1.13, 95&nb...

Psychological outcomes following surgical excision of facial skin cancers

European Journal of Plastic Surgery — Sat, 11 Aug 2012 17:18:31 +0100

Conclusion Lower preoperative SCI scores confirm the presence of anxiety among patients with cutaneous facial malignancies. Surgical excision improves social, emotional and cosmetic well-being, particularly in patients with squamous cell carcinomas. Female and younger patients appear most vulnerable to QOL anxieties preoperatively. Level of Evidence: Level III, prognostic study. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00238-012-0748-5Authors J. Caddick, Department of Plastic Surgery, Pinderfields General Hospital, Aberford Road, Wakefield, WF1 4DG UKJ. Stephenson, School of Human and Health Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH UKL. Green, Department of Plastic Surgery, Pinderfields General Hosp...

Factors Affecting Sunscreen Use and Sun Avoidance in a U.S. National Sample of Organ Transplant Recipients.

The British Journal of Dermatology — Thu, 09 Aug 2012 04:00:00 +0100

Conclusions: Both patient features and clinician advice are associated with sun protective behaviours after organ transplantation. These results help physicians target expanded sun protection counseling to those patients most in need of such intervention. PMID: 22880814 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Letter: Basal cell carcinoma with vascular invasion.

Dermatol Online J — Wed, 08 Aug 2012 00:00:03 +0100

We report a primary cutaneous BCC on the upper chest in which vascular invasion was demonstrated by histopathology and the unique application of dual immunohistochemistry. PMID: 22559028 [PubMed - in process] (Source: Dermatol Online J)

Hong Kong hospital deploys SRT-100 superficial radiotherapy system

Hospital Management — Tue, 07 Aug 2012 23:00:00 +0100

Hong Kong Sanatorium & Hospital in Hong Kong has deployed Sensus Healthcare's superficial radiotherapy system, SRT-100, to treat a series of skin maladies and non-melanoma skin cancers. (Source: Hospital Management)

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Actinic keratosis in the en-face and slice imaging mode of high definition optical coherence tomography and comparison with histology.

The British Journal of Dermatology — Sat, 04 Aug 2012 04:00:00 +0100

Conclusion: HD-OCT with both the en-face and slice imaging mode offers additional information in the diagnosis of AK compared to conventional OCT and might enhance the possibility of the non-invasive diagnosis of AK prior to treatment procedures and possibly in the monitoring of non-invasive treatment strategies. PMID: 22861068 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Weather conditions and daylight-mediated photodynamic therapy - Protoporphyrin IX weighted daylight doses measured in 6 geographic localisations.

The British Journal of Dermatology — Sat, 04 Aug 2012 04:00:00 +0100

Conclusion: Where and when to perform daylight-PDT depends on the PpIX light dose and outdoor temperature. The PpIX light dose was influenced by the geographic location (latitude), weather condition and time of year. The UV-index was not more suitable than temperature and weather to predict if the intensity of daylight would be sufficient for daylight-PDT. PMID: 22860885 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Recommendations for CTV margins in radiotherapy planning for non melanoma skin cancer

Radiotherapy and Oncology — Thu, 02 Aug 2012 04:00:00 +0100

Conclusions: Tumors greater than 2cm and SCC histology required larger margins to adequately cover the microscopic extent of disease. This information is crucial in radiation planning of NMSC. Clinicians should be cautioned, as these guidelines may not offer optimum treatment for patients with extremely large or small lesions. (Source: Radiotherapy and Oncology)

A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer.

Cancer Control — Wed, 01 Aug 2012 04:00:00 +0100

Conclusions: This experiment suggests that LLLT at these parameters may be safe even when malignant lesions are present. Further studies on the effects of photoirradiation on neoplasms are warranted. PMID: 22853435 [PubMed - as supplied by publisher] (Source: Cancer Control)

Recommendations for CTV margins in radiotherapy planning for non melanoma skin cancer.

Tue, 31 Jul 2012 04:00:00 +0100

CONCLUSIONS: Tumors greater than 2cm and SCC histology required larger margins to adequately cover the microscopic extent of disease. This information is crucial in radiation planning of NMSC. Clinicians should be cautioned, as these guidelines may not offer optimum treatment for patients with extremely large or small lesions. PMID: 22857860 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

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Efficacy of walking exercise in promoting cognitive-psychosocial functions in men with prostate cancer receiving androgen deprivation therapy

BMC Cancer — Mon, 30 Jul 2012 04:00:00 +0100

This study addresses this issue by designing a simple and accessible home-based, exercise program that may potentially have significant impact on reducing the cognitive and psychosocial side effects of ADT, and ultimately improving the health-related quality of life in men with prostate cancer receiving ADT. (Source: BMC Cancer)

Incidence of Nonmelanoma Skin Cancer in Ireland.

The British Journal of Dermatology — Fri, 27 Jul 2012 04:00:00 +0100

Authors: Bennett M, Comber H, Deady S Abstract we read with interest the article by Lomas et al.,(1) which provides an extensive overview of the worldwide incidence of nonmelanoma skin cancer (NMSC). Data was collected from 75 studies over the past fifty years. However recent data that has been published on the incidence of NMSC in Ireland by Carsin et al.,(2) was not included in the review, presumably as this paper only became available online in April 2011, which post-dated Lomas's cut-off search date of March 2011. Carsin et al used the National Cancer Registry of Ireland (NCRI) NMSC data to investigate geographic, urban/rural and socioeconomic variations. PMID: 22835212 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Stem cells of the human epidermis and their niche: composition and function in epidermal regeneration and carcinogenesis

Carcinogenesis — Thu, 26 Jul 2012 04:00:00 +0100

Skin, as the largest organ, has long been subject of excellent and pioneering studies on stem cells and their role in tissue regulation and tumor formation. In particular, intensive research on mouse skin, and here especially the hair follicle, has largely extended our knowledge. Surprisingly, human skin, although the most easily accessible tissue in man, is far less conceived with regard to its stem cells and their specific environment (the niche). In consequence, these features are as yet only insufficiently defined and it still has to be elucidated how insights in cutaneous stem cell biology gained in mice can be extrapolated to humans. In the last few years, human model systems such as humanized mice or in vitro organotypic cultures that support maintenance or reconstruction of human s...

Incidence of Nonmelanoma Skin Cancer in Ireland

British Journal of Dermatology — Thu, 26 Jul 2012 04:00:00 +0100

Abstractwe read with interest the article by Lomas et al.,1 which provides an extensive overview of the worldwide incidence of nonmelanoma skin cancer (NMSC). Data was collected from 75 studies over the past fifty years. However recent data that has been published on the incidence of NMSC in Ireland by Carsin et al.,2 was not included in the review, presumably as this paper only became available online in April 2011, which post‐dated Lomas’s cut‐off search date of March 2011. Carsin et al used the National Cancer Registry of Ireland (NCRI) NMSC data to investigate geographic, urban/rural and socioeconomic variations. (Source: British Journal of Dermatology)

Indoor Tanning Ban For Minors Hits New York

Health News from Medical News Today — Fri, 20 Jul 2012 16:00:00 +0100

On Monday, July 16, New York Governor Andrew Cuomo signed a bill that will ban children under the age of 16 from using indoor tanning beds. In addition, 17-year-olds will have to obtain parental consent in order to use tanning beds. The bill will go into effect in 30 days. Daniel M. Siegel, MD, FAAD, president of the American Academy of Dermatology Association and a New York-based dermatologist, explained: "The American Academy of Dermatology Association commends New York for joining in the fight against melanoma, the deadliest form of skin cancer, and non-melanoma skin cancers... (Source: Health News from Medical News Today)

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Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs.

Biochemical and Biophysical Research communications — Fri, 20 Jul 2012 04:00:00 +0100

Authors: Arumugam A, Walsh SB, Xu J, Afaq F, Elmets CA, Athar M Abstract Non-melanoma skin cancers (NMSCs) are the most common neoplasm in organ transplant recipients (OTRs). These cancers are more invasive and metastatic as compared to those developed in normal cohorts. Previously, we have shown that immunosuppressive drug, cyclosporine A (CsA) directly alters tumor phenotype of cutaneous squamous cell carcinomas (SCCs) by activating TGF-β and TAK1/TAB1 signaling pathways. Here, we identified novel molecular targets for the therapeutic intervention of these SCCs. We observed that combined blockade of Akt and p38 kinases-dependent signaling pathways in CsA-promoted human epidermoid carcinoma A431 xenograft tumors abrogated their growth by more than 90%. This diminution in tumor gr...

Epigenetic inactivation of the E‐cadherin gene in eyelid sebaceous gland carcinoma

British Journal of Dermatology — Thu, 19 Jul 2012 04:00:00 +0100

Conclusion Epigenetic inactivation of the E‐cadherin gene causes loss of membrane‐bound E‐cadherin and could contribute to the reduced disease‐free survival in eyelid sebaceous gland carcinoma. Mutations in the β‐catenin gene do not seem to be involved in the pathogenesis of eyelid sebaceous gland carcinoma. (Source: British Journal of Dermatology)

Nonmelanoma Skin Cancer and IBDNonmelanoma Skin Cancer and IBD

Medscape Today Headlines — Wed, 18 Jul 2012 14:47:02 +0100

Nonmelanoma skin cancer is an increasingly recognized risk related to therapy for inflammatory bowel disease. Medscape Gastroenterology (Source: Medscape Today Headlines)

Nonmelanoma Skin Cancer in Solid Organ Transplant Recipients: Update on Epidemiology, Risk Factors, and Management

Dermatologic Surgery — Tue, 17 Jul 2012 04:00:00 +0100

ConclusionsNMSC is the most frequent cancer observed in SOTR. Early diagnosis, patient education, and modification of immunosuppression are effective measures for reduction of NMSC incidence. (Source: Dermatologic Surgery)

Review: Daily aspirin reduces short-term risk for cancer and cancer mortality.

Annals of Internal Medicine — Tue, 17 Jul 2012 04:00:00 +0100

CONCLUSION Daily aspirin reduces short-term risk for incident cancer and cancer mortality.Aspirin vs no aspirin for prevention of vascular events*OutcomesNumber of trials (n)Weighted event ratesRRR (95% CI)NNT (CI)AspirinNo aspirinCancer mortality†34 (69 224)1.5%1.8%15% (4 to 24)380 (237 to 1427)Nonvascular mortality†51 (77 549)2.6%2.8%12% (4 to 22)295 (161 to 884)Primary preventionVascular mortality†‡12 (42 356)2.30%2.32%1% (-12 to 13)NSNonvascular mortality†‡12 (42 356)2.8%3.1%12% (2 to 21)274 (149 to 1645)Incident cancer at 3 to 4.9 y§6 (32 947)1.2%1.4%19% (2 to 33)371 (213 to 3528)Incident cancer at ≥ 5 y§6 (8904)2.9%4.1%29% (12 to 43)84 (57 to 210)RRI (CI)NNH (CI)Incident cancer at 0 to 2.9 y§6 (35 535)2.51%2.48%1% (-12 to 15)NS*NS = not significant; other abbr...

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Prevalence of human polyomaviruses in common and rare types of non-Merkel cell carcinoma skin cancer.

The British Journal of Dermatology — Sat, 14 Jul 2012 04:00:00 +0100

Conclusions: Our findings argue against a pathogenic role of MCPyV, HPyV6, HPyV7, TSV, and HPyV9 in the analyzed types of non-Merkel cell carcinoma skin cancer. PMID: 22803598 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Diseases Increasingly Showing Up In Younger Age Groups

Wed, 11 Jul 2012 03:29:41 +0100

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Diseases Showing Up More In Younger Age Groups

Wed, 11 Jul 2012 03:29:41 +0100

NF-κB signalling is attenuated by the E7 protein from cutaneous human papillomaviruses.

Virus Research — Sat, 07 Jul 2012 04:00:00 +0100

Authors: Byg LM, Vidlund J, Vasiljevic N, Clausen D, Forslund O, Norrild B Abstract The high-risk Alpha-types of human papillomavirus (HPV) are the causative agent of cervical cancer, which is the second major cause of death among women worldwide. Recent investigations have shown that E7 from the Alpha-papillomavirus HPV-16 interacts with IKKα and IKKβ of the IKK complex in the NF-κB pathway leading to an attenuation of the activity. There is a possible link between development of non-melanoma skin cancer and cutaneous Beta-papillomavirus but if these HPV types attenuate the NF-κB pathway is unclear. Seven different E7 proteins, representing four out of the five different species of the Beta genus (HPV-20, -37, -38, -92, -93 and -96) and one from the Gamma genus (HPV-4) were in...

Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer.

Pigment Cell and Melanoma Research — Thu, 05 Jul 2012 04:00:00 +0100

Authors: Meng S, Zhang M, Liang L, Han J Abstract Genome-wide association studies (GWAS) have become a widely used approach for genetic association studies of various human traits. A few GWAS have been conducted with the goal of identifying novel loci for pigmentation traits, melanoma, and non-melanoma skin cancer. Nevertheless, the phenotype variation explained by the genetic markers identified so far is limited. In this review, we discuss the GWAS study design and its application in pigmentation and skin cancer research. Furthermore, we summarize recent developments in post-GWAS activities such as meta-analysis, pathway analysis, and risk prediction. PMID: 22762390 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)

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Cutaneous Squamous Cell Carcinoma: Defining the High-Risk Variant.

Actas Dermo-Sifiliograficas — Thu, 05 Jul 2012 04:00:00 +0100

This article analyzes the various factors that define aggressive CSCC. We propose a method for defining high-risk SCC on the basis of a series of major and minor criteria. This method will allow better prognostic evaluation and enable personalized management of patients with high-risk SCC, possibly leading to improved overall survival. PMID: 22770898 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Multiple eruptive squamous cell carcinoma in a patient with chronic plaque psoriasis on adalimumab.

The Australasian Journal of Dermatology — Tue, 03 Jul 2012 04:00:00 +0100

Authors: Simpkin S, Oakley A Abstract A 67-year-old man with chronic plaque psoriasis previously treated with psoralen plus PUVA, ciclosporin, methotrexate and acitretin developed eruptive squamous cell carcinoma after seven doses of adalimumab. We review the association of squamous cell carcinoma with immunosuppressive agents used for the treatment of chronic plaque psoriasis. Initiation of tumour necrosis factor (TNF)-α inhibitors in a patient at high risk of non-melanoma skin cancer may warrant chemoprophylaxis with acitretin. PMID: 22758905 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)

Subsequent Nonmelanoma Skin Cancer after Liver Transplantation

Transplantation Proceedings — Sun, 01 Jul 2012 04:00:00 +0100

Conclusion: NMSC are frequent complications after liver transplantation and they may show a high rate of recurrence. Older age and hepatocellular carcinoma were related to the development of multiple NMSC. (Source: Transplantation Proceedings)

[Safety of immunosuppressants].

Hamostaseologie — Sun, 01 Jul 2012 04:00:00 +0100

Authors: Psenak O, Studnicka-Benke A, Greil R Abstract METABOLISM: Cyclosporin A and leflunomide may increase the blood pressure, whereas administration of prednisolone and tacrolimus may cause hyperglycemia. Azathioprine, chloroquine, methotrexate and mycophenolate mofetil seem to be metabolically neutral. Tocilizumab and tumor necrosis factor (TNF) alpha blockers have a negative effect on the lipid profile. INFECTIONS: The overall infection risk for prednisolone is estimated to be 1.3. This risk for methotrexate is also 1.3 compared to other disease modifying antirheumatic drugs (DMARDs). Regarding biologics, the highest risk of serious infections was associated with certolizumab pegol and tocilizumab, in contrast to abatacept and ri...