MedWorm: Ovarian Cancer

Melanoma metastasis to the breast: A diagnostic pitfall

Cancer Detection and Prevention — Wed, 01 Jul 2009 15:01:19 +0100

Conclusion: Although no strict clinical criteria exist to differentiate a melanoma metastasis to the breast from a primary breast carcinoma atypically rapid growth, normal Ca 15-3 level, and a history of prior melanoma may be helpful. However, it may be still misdiagnosed in some cases even histopathologically if the immunohistochemical staining is not performed. (Source: Cancer Detection and Prevention)

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European Urology July Issue Reviews Prostate Screening Studies

Health News from Medical News Today — Wed, 01 Jul 2009 07:00:00 +0100

The July issue of European Urology, the official journal of the European Association of Urology, features an editorial by Lars Holmberg comparing the results from the European Randomised Study of Screening for Prostate Cancer (ERSPC) with the results from the Prostate, Lung, Colorectal and Ovarian Ca (Source: Health News from Medical News Today)

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase-Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

It has been reported that levo-1-methyl tryptophan (L-1MT) can block indoleamine-2,3-dioxygenase (IDO) expressed by human dendritic cells (DC), whereas dextro-1-methyl tryptophan (D-1MT) is inefficient. However, whether L-1MT or D-1MT can efficiently reverse IDO-induced arrest of human T-cell proliferation has not been clarified. Here, we show a marked immunosuppressive effect of IDO derived from INDO-transfected 293 cell, IDO+ ovarian cancer cells, and monocyte-derived DCs on CD4+ Th1 cells, CD8+ T cells, and natural killer cells derived from peripheral blood, ascites, and tumors of ovarian cancer patients. We found that, whereas L-1MT and D/L-1MT can restore proliferation of tumor-derived and peripheral blood T-cell subsets, D-1MT does not effectively restore IDO-induced arrest of T-cell...

Harnessing Competing Endocytic Pathways for Overcoming the Tumor-Blood Barrier: Magnetic Resonance Imaging and Near-Infrared Imaging of Bifunctional Contrast Media

Cancer Research — Tue, 30 Jun 2009 23:00:00 +0100

Ovarian cancer is the most lethal gynecologic malignancy, often diagnosed at advanced stage leading to poor prognosis. In the study reported here, magnetic resonance imaging and near-infrared reflectance imaging were applied for in vivo analysis of two competing endocytic pathways affecting retention of bifunctional daidzein-bovine serum albumin (BSA)–based contrast media by human epithelial ovarian carcinoma cells. Suppression of caveolae-mediated uptake using nystatin or by BSA competition significantly enhanced daidzein-BSA-GdDTPA/CyTE777 uptake by tumor cells in vitro. In vivo, perivascular myofibroblasts generated an effective perivascular barrier excluding delivery of BSA-GdDTPA/CyTE777 to tumor cells. The ability to manipulate caveolae-mediated sequestration of albumin by peri...

First Baby Is Born After A New Technique

Health News from Medical News Today — Tue, 30 Jun 2009 12:00:00 +0100

A new technique for transplanting the ovaries of women who have lost their fertility as a result of cancer treatment was outlined to the 25th annual conference of the European Society of Human Reproduction and Embryology. Dr. (Source: Health News from Medical News Today)

New Ovarian Transplantation Technique Gives Greatly Improved Results In This Delicate Operation

Health News from Medical News Today — Tue, 30 Jun 2009 10:00:00 +0100

Ultra-fast freezing of ovarian tissue from women who have lost their fertility as a result of cancer treatment can lead to it being used in transplants with the same success rate as fresh tissue, a researcher told the 25th annual conference of the European Society of Human Reproduction and Embryology 29 June. Dr. Sherman Silber, Director of the St. Louis Infertility Centre, St. (Source: Health News from Medical News Today)

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[News] 2009 ASCO Annual Meeting

The Lancet Oncology — Mon, 29 Jun 2009 23:00:00 +0100

Gordon Rustin (Northwood, UK) and colleagues presented findings of the MRC OV05/EORTC 55955 randomised trial, which aimed to assess whether treatment for relapsed ovarian cancer should begin as soon as blood tests show increases in the concentration of CA125, or whether it should be delayed until clinically indicated. Of the 1442 women who were enrolled when in complete remission after treatment with first-line platinum-containing regimens, 527 subsequently relapsed. Of these patients, 264 were randomly assigned to the immediate treatment group and 263 to the delayed treatment group. After a median follow-up of 49 months, during which time 351 of the women died, the researchers noted no difference in overall survival between the groups (hazard ratio [HR] 1·00 [95% CI 0·82–1·22]; p=0·...

DNA methylation and histone modification regulate silencing of OPG during tumor progression

Journal of Cellular Biochemistry — Mon, 29 Jun 2009 23:00:00 +0100

The identification of molecules that are down-regulated in malignant phenotype is important for understanding tumor biology and their role in tumor suppression. We compared the expression profile of four normal nasal mucosal (NNM) epithelia and a series of nasopharyngeal cancinoma (NPC) cell lines using cDNA microarray and confirmed the actual expression of the selected genes, and found osteoprotegerin (OPG) to be ubiquitously deficient in NPC cells. We also found OPG to be down-regulated in various cancer cell lines, including oral, cervical, ovarian, lung, breast, pancreas, colon, renal, prostate cancer, and hepatoma. Administration of recombinant OPG (rOPG) brought about a reduction in cancer cell growth through apoptotic mechanism. We generated eleven monoclonal antibodies (MAbs) again...

Height and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial

British Journal of Cancer AOP — Mon, 29 Jun 2009 23:00:00 +0100

Authors: J Ahn, S C Moore, D Albanes, W-Y Huang, M F Leitzmann & R B Hayes (Source: British Journal of Cancer AOP)

Screening: Ovarian cancer: feasibility of early detection

Nature Clinical Practice Oncology — Mon, 29 Jun 2009 15:02:57 +0100

Nature Reviews Clinical Oncology 6, 375 (2009). doi:10.1038/nrclinonc.2009.79 Author: Vessela Vassileva (Source: Nature Clinical Practice Oncology)

First International Conference On Cancer Of Unknown Primary To Be Held London October 15

Cancer / Oncology News From Medical News Today — Mon, 29 Jun 2009 09:00:00 +0100

When a patient is diagnosed with metastatic disease the primary site of the cancer is usually, but not always, evident. When the origin of the cancer is not identified it is described as a Cancer of Unknown Primary site, or CUP. Each year in the UK over 10,000 people are diagnosed with CUP. This is a higher incidence than known cancers such as pancreatic, ovarian, uterine, kidney, brain, cervical or blood (leukaemia) cancers. (Source: Cancer / Oncology News From Medical News Today)

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Widespread Confusion About Ovarian Cancer Signs Says UK Charity

Women's Health / OBGYN News From Medical News Today — Mon, 29 Jun 2009 07:00:00 +0100

There is widespread confusion among women and doctors about the signs of ovarian cancer, said a UK charity behind a study being published today, Monday 29 June, at the House of Commons. The Target Ovarian Cancer Pathfinder study surveyed 400 UK general practitioners (GPs) and over 1,000 women, including 132 with ovarian cancer, and found 80 per cent of GPs were wrongly of the view that women have no symptoms in the early stages of ovarian cancer. (Source: Women's Health / OBGYN News From Medical News Today)

James F. Amatruda

bizjournals.com Health Care:Industry Regulation headlines — Mon, 29 Jun 2009 04:00:00 +0100

A recognized leader and innovator in pediatric germ cell research, Dr. James F. Amatruda is the head of the Germ Cell Tumor Biology Committee for the Children’s Oncology Group, a national organization that treats every pediatric patient in the Unites States affected by germ-cell tumors. Amatruda has earned recognition for his discovery of a gene mutation in zebrafish (small aquarium fish with human-like genes that allow scientists to identify triggers and observe how cancers grow and spread) that causes tumors in germ cells. Such tumors can be the source of testicular cancer, ovarian cancer and other pediatric tumors. The discovery of the gene mutation has been hailed as a significant breakthrough in pediatric cancer research because germ-cell tumors are unusual in their composition, and...

James F. Amatruda

bizjournals.com Health Care:Physician Practices headlines — Mon, 29 Jun 2009 04:00:00 +0100

James F. Amatruda

bizjournals.com Health Care:Health Insurance headlines — Mon, 29 Jun 2009 04:00:00 +0100

James F. Amatruda

bizjournals.com Health Care:Pharmaceuticals headlines — Mon, 29 Jun 2009 04:00:00 +0100

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Ovarian Transplantation: New Technique Gives Greatly Improved Results In This Delicate Operation

ScienceDaily Headlines — Mon, 29 Jun 2009 04:00:00 +0100

Ultra-fast freezing of ovarian tissue from women who have lost their fertility as a result of cancer treatment can lead to it being used in transplants with the same success rate as fresh tissue, according to new research. Scientists said that freezing tissue by the vitrification method, which avoids ice formation, meant that oocyte (egg) viability was almost identical with that seen in fresh oocytes. (Source: ScienceDaily Headlines)

Ovarian Transplantation: First Baby Is Born With New Technique

ScienceDaily Headlines — Mon, 29 Jun 2009 04:00:00 +0100

A new technique for transplanting the ovaries of women who have lost their fertility has been developed. The new, two-step method of ovarian transplant has produced excellent results in women whose ovaries have been frozen because of cancer treatment. (Source: ScienceDaily Headlines)

Ovarian transplantation: New technique gives greatly improved results in this delicate operation

EurekAlert! - Biology — Mon, 29 Jun 2009 04:00:00 +0100

(European Society for Human Reproduction and Embryology) Ultra-fast freezing of ovarian tissue from women who have lost their fertility as a result of cancer treatment can lead to it being used in transplants with the same success rate as fresh tissue. This technique has already produced pregnancies, and represents a considerable advance on existing methods of ovarian grafting. (Source: EurekAlert! - Biology)

James F. Amatruda

bizjournals.com Health Care:Biotechnology headlines — Mon, 29 Jun 2009 04:00:00 +0100

James F. Amatruda

bizjournals.com Health Care:Hospitals headlines — Mon, 29 Jun 2009 04:00:00 +0100

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Prostate screening studies reviewed in European Urology July issue

EurekAlert! - Social and Behavioral Science — Mon, 29 Jun 2009 04:00:00 +0100

(European Association of Urology) The July issue of European Urology, the official journal of the European Association of Urology, features an editorial by Lars Holmberg comparing the results from the European Randomized Study of Screening for Prostate Cancer with the results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. (Source: EurekAlert! - Social and Behavioral Science)

Assessing extreme drug resistance in EOC fails to alter patient outcomes

MedWire News - Ob/Gyn — Mon, 29 Jun 2009 00:00:00 +0100

Routinely assessing extreme drug resistance in women with epithelial ovarian cancer is not recommended as the results do not predict or alter treatment outcomes, US researchers believe. (Source: MedWire News - Ob/Gyn)

Ovary cancer signs 'confusion'

BBC News | Health | UK Edition — Sun, 28 Jun 2009 23:13:26 +0100

There is "widespread confusion" amongst doctors and women about ovarian cancer, a charity has said. (Source: BBC News | Health | UK Edition)

GPs' failure to spot ovarian cancer is costing lives

Guardian Unlimited Science — Sun, 28 Jun 2009 23:05:03 +0100

Nearly half of women have to wait six months for a correct diagnosis of the 'silent killer', and third must visit their doctor several times before seeing a specialistWomen are dying unnecessarily of ovarian cancer because GPs fail to spot warning signs, according to experts.Large numbers of family doctors cannot correctly identify the cancer's symptoms, according to a major study published today. It found that 37% of women visit their GP several times before their cancer is detected, and 65% are not referred for a test right away.The charity Target Ovarian Cancer's study, in which leading doctors played a key role, found widespread ignorance among GPs about the symptoms and that some mistook it for other, less serious illnesses such as irritable bowel syndrome.The study found that 44% of ...

A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example

BMC Cancer — Sun, 28 Jun 2009 23:00:00 +0100

Conclusions: Although co-segregation analysis on itself is in most cases insufficient to prove pathogenicity of an UV, this method simplifies the use of co-segregation as one of the key features in a multifactorial approach considerably. (Source: BMC Cancer)

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Paper round: Monday

OnMedica Latest News — Sun, 28 Jun 2009 23:00:00 +0100

Doctors unable to diagnose ovarian cancer, survival guide for festivals, and moreRelated items from OnMedicaMore than nine in ten doctors worried by PFIAlcohol accounts for one in 25 deaths worldwide Seperate studies show jury out on aneurysm screening costsThousands unaware they have genetic heart riskJunior doctor rotas will comply with European directive deadline (Source: OnMedica Latest News)

[Gynecologic Cancer] Safety and Efficacy of Patupilone in Patients With Advanced Ovarian, Primary Fallopian, or Primary Peritoneal Cancer: A Phase I, Open-Label, Dose-Escalation Study

Journal of Clinical Oncology — Sun, 28 Jun 2009 23:00:00 +0100

Conclusion Patupilone once every 3 weeks was well-tolerated at doses up to 11.0 mg/m2. Patupilone demonstrated promising antitumor activity in patients with drug-resistant/refractory disease. An ongoing phase III study in this patient population is testing the 10.0 mg/m2 dose. (Source: Journal of Clinical Oncology)

The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.

The International Journal of Biochemistry and Cell Biology — Sun, 28 Jun 2009 04:03:37 +0100

In this study we describe a novel function of this physiologically relevant form of L1 as a pro-angiogenic factor. We demonstrated that the anti-L1 monoclonal antibody (mAb) chCE7 binds near or to the sixth Ig-like domain of human L1 which contains a single RGD sequence. mAb chCE7 inhibited the RGD-dependent adhesion of ovarian carcinoma cells to sL1 and reversed the sL1-induced proliferation, matrigel invasion and tube formation of bovine aortic endothelial (BAE) cells. A combination of sL1 with vascular endothelial growth factor-A (VEGF-A(165)), which is an important angiogenic inducer in tumors, strongly potentiated VEGF receptor-2 tyrosine phosphorylation in BAE cells. Chick chorioallantoic membrane (CAM) assays revealed the pro-angiogenic potency of sL1 in vivo which could be abolishe...

Antiproliferative compounds of Helmiopsis sphaerocarpa from the Madagascar rainforest.

Natural Product Research — Sun, 28 Jun 2009 03:54:03 +0100

Authors: Cao S, Brodie P, Miller JS, Birkinshaw C, Rakotondrafara A, Andriantsiferana R, Rasamison VE, Kingston DG Bioassay-directed separation of an ethanol extract of the leaves of Helmiopsis sphaerocarpa L.C. Barnett (Sterculiaceae) led to the isolation of the new compound 14alpha,15alpha-epoxy-3beta-hydroxytaraxerane (1) and the four known compounds taraxerol (2), stigmast-5-en-3-ol (3), 5alpha,8alpha-epidioxy-24(S)-methylcholesta-6,22-dien-3beta-ol (4), and 24xi-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3-one (5). The structure of the new compound 1 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. All the compounds were tested against A2780 human ovarian cancer cell lines, and compounds 4 and 5 showed mild antiproliferative activity, with IC...

Vitamin D for cancer prevention: global perspective.

Annals of Epidemiology — Sun, 28 Jun 2009 02:05:11 +0100

CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium. PMID: 19523595 [PubMed - in pr...

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Molecular characterization of a new ovarian cancer cell line, YDOV-151, established from mucinous cystadenocarcinoma.

The Tohoku Journal of Experimental Medicine — Sat, 27 Jun 2009 22:29:03 +0100

Authors: Cho H, Lim BJ, Kang ES, Choi JS, Kim JH Ovarian cancer is a leading cause of death among gynecological malignancies. Established cancer cell lines are useful tools for clinical and basic researches. We have therefore established a new human ovarian cancer cell line, YDOV-151, derived from the mucinous cystadenocarcinoma and characterized it by the microarray analyses. A mucinous origin of the YDOV-151 was evident from light microscopy, and its epithelial-like character was confirmed with electron microscopy. No pathogenic mutations were found in the BRCA1 and BRCA2 genes. The subcutaneous transplantation of YDOV-151 cells into nude mice successfully induced the tumor mass after 3 weeks. cDNA microarray analysis revealed 1,926 genes (> 2-fold differences, P < 0.05) that d...

Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer.

The American Journal of Pathology — Sat, 27 Jun 2009 20:42:28 +0100

In this study, we demonstrated that IKKepsilon is frequently overexpressed and activated in human ovarian cancer cell lines and primary tumors. Of 96 ovarian cancer specimens examined, 63 exhibited elevated levels of IKKepsilon. Furthermore, alterations of IKKepsilon were associated with late-stage and high-grade tumors, suggesting a role of IKKepsilon in ovarian tumor progression rather than in tumor initiation. Overall survival in patients with elevated levels of IKKepsilon was significantly lower than patients whose tumors expressed normal levels of IKKepsilon. Moreover, both early and late-stage tumors that overexpressed IKKepsilon conferred a poor prognosis, as compared with those that did not possess elevated IKKepsilon levels. Notably, overexpression of IKKepsilon rendered cells res...

Pulmonary morbidity of diaphragmatic surgery for stage III/IV ovarian cancer.

BJOG : An International Journal of Obstetrics and Gynaecology — Sat, 27 Jun 2009 20:01:54 +0100

CONCLUSIONS: Diaphragm peritonectomies and resections are an effective way to cytoreduce diaphragm carcinomatosis and increase the rate of optimal debulking surgery. Such procedures frequently result in pleural effusion, but with no long-term morbidity. PMID: 19459863 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Coexistence of Copy Number Increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in Ovarian Cancers.

Onkologie — Sat, 27 Jun 2009 14:28:03 +0100

Conclusions: Our results revealed a combination between copy number increases of c-mycand ZNF217, associated with serous histology. The data from this combined analysis of the 5 oncogenes could be used as a basis in considering the combined approach in molecular-based therapy of ovarian cancer. PMID: 19556818 [PubMed - as supplied by publisher] (Source: Onkologie)

[Evaluating treatment from the point of view of the patient -PROs (patient-reported outcomes)]

Onkologie — Sat, 27 Jun 2009 14:28:03 +0100

This article describes the significance of PROs from the point of view of a social scientist, a gynaecologist, and an affected patient. PMID: 19521131 [PubMed - in process] (Source: Onkologie)

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The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol.

Neoplasma — Sat, 27 Jun 2009 13:40:03 +0100

Authors: Mezencev R, Kutschy P, Salayova A, Updegrove T, McDonald JF Nitrogen mustards cis-1-methoxy-2-deoxy-2-[N,N-bis(2 -chloroethyl)amino]spirobrassinol (4) and trans-1-methoxy-2-deoxy-2-[N,N-bis(2 -chloroethyl)amino]spirobrassinol (5) derived from 1-methoxyspirobrassinol, an indole phytoalexin produced by the Japanese radish Raphanus sativus var. hortensis were designed as prospective dual-action compounds with DNA-alkylating effect and glutathione-depleting effects that may sensitize cancer cells to alkylating agents. Both new compounds demonstrated cytostatic/cytotoxic effects on various leukemia and ovarian cancer cell lines and dsDNA-destabilizing effects in vitro. Compound 4, the more promising of the two compounds, exerts earlier onset of anticancer effects on Jurkat cells vi...

Gemcitabine and carboplatin treatment in Patients with relapsing ovarian cancer.

Neoplasma — Sat, 27 Jun 2009 13:40:03 +0100

Authors: Sufliarsky J, Chovanec J, Svetlovska D, Minarik T, Packan T, Kroslakova D, Lalabova R, Helpianska L, Horvathova D, Sevcik L, Spacek J, Laluha A, Tkacova V, Malec V, Rakicka G, Magdin D, Jancokova I, Dorr A, Stresko M, Habetinek V, Koza I Despite progress in primary treatment of patients with advanced ovarian cancer, the majority develop recurrence of the disease. A platinum salt treatment, either as monotherapy or in combination with another cytostatic agent, is indicated for patients who have relapsed 6 or more months after primary treatment and thus have platinum-sensitive relapse. Because repeated use of paclitaxel treatment may lead to substantial neurotoxicity, the combination of gemcitabine with carboplatin represents a suitable treatment option, which is widely used in ...

Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies -central European experience.

Neoplasma — Sat, 27 Jun 2009 13:40:03 +0100

Authors: Bencko V, Rames J, Ondrusova M, Plesko I, Jurickova L, Trnovec T This paper describes results of two ecological studies design to analyze the incidence of selected malignancies in two populations exposed to polychlorinated hydrocarbons, mostly PCBs and TCDDs/Fs by comparing data available in the National Cancer Registry of the Slovak Republic and National Oncological Registry of the Czech Republic databases for the Slovak Republic (~ 5M inhabitants) and the Czech Republic (10,3 Minhabitants) to the data relevant for the population of Michalovce District, the Slovak Republic (~ 112,000 inhabitants) and Uherske Hradiste, the Czech Republic (146,000 inhabitants). Those districts are recognized as PCB-contaminated areas due to production and industrial use of PCBs. <br />Dat...

Endothelin-1 inhibition by ambrisentan as a potential treatment adjunct after debulking surgery in epithelial ovarian cancer.

Oncology Research — Sat, 27 Jun 2009 13:39:05 +0100

Authors: Kast RE The 21 amino acid signaling peptide endothelin-1 is commonly elevated in epithelial ovarian cancer, and it mediates or facilitates much of this cancer's aggressive behavior. Ambrisentan (Letairis; Gilead Sciences Inc.) is an antagonist of endothelin-1 at its cognate receptor that has just been approved to treat pulmonary hypertension. Ambrisentan is a well-tolerated pill taken once daily. In theory, it should retard and inhibit lodgement and establishment of disseminated peritoneal micrometastases after debulking surgery. PMID: 19544975 [PubMed - in process] (Source: Oncology Research)

Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo.

International Journal of Oncology — Sat, 27 Jun 2009 13:38:22 +0100

Authors: Heinze E, Baldwin S, Chan G, Hansen J, Song J, Clements D, Aragon R, Nishimura R, Reeves M, Weisbart R In addition to its immune suppressive function in T-regulatory cells, the nuclear transcription factor, FOXP3, has been identified as a tumor suppressor. To evaluate the clinical efficacy of monoclonal antibody (mAb) 3E10 Fv antibody-mediated FOXP3 protein therapy of cancer, the Fv-FOXP3 fusion protein produced in Pichia pastoris was tested on breast, ovarian, and colon cancer cells in vitro, and with colon cancer cells in vivo in a mouse model of colon cancer metastasis to liver. Treatment with Fv-FOXP3 resulted in dose-dependent cell death of cancer cells in vitro. Apoptosis was established as a mechanism of cell death by demonstrating increased production of the p17 activa...

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Cancer cell-expressed immunoglobulins: CA215 as a pan cancer marker and its diagnostic applications.

Cancer Biomarkers : Section A of Disease Markers — Sat, 27 Jun 2009 13:27:03 +0100

CONCLUSIONS: The results of these multi-center clinical studies suggest that CA215 is a suitable pan cancer marker for the monitoring of ovarian/cervical cancers and maybe of several others which express CA215 and can be detected in human circulations. PMID: 19407368 [PubMed - in process] (Source: Cancer Biomarkers : Section A of Disease Markers)

BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts.

Cellular Oncology — Sat, 27 Jun 2009 13:25:03 +0100

CONCLUSIONS: The delayed cytokinesis phenotype of the BRCA2 heterozygous cells and localization of the BRCA2 protein to the midbody confirms that BRCA2 plays a role in cytokinesis. Our observations indicate that in a subset of cells the presence of only one wild type BRCA2 allele is insufficient for efficient cytokinesis. PMID: 19478387 [PubMed - in process] (Source: Cellular Oncology)

Antitumor efficacy induced by human ovarian cancer cells secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model.

Immunobiology — Sat, 27 Jun 2009 13:00:05 +0100

Authors: Dou J, Wang Y, Wang J, Zhao F, Li Y, Cao M, Hu W, Hu K, He XF, Chu L, Jiang C, Gu N The ovarian cancer cells (SKOV3) secreting IL-21 alone or combination with GM-CSF cytokines was developed and its antitumor effect was evaluated in the nude mice. The gene of IL-21 was amplified from plasmid pRSC-IL-21 by PCR, cloned into the plasmid pRSC-GM-CSF, and the plasmid pRSC-GM-CSF-IL21 was constructed. The plasmids of pRSC-GM-CSF, pRSC-IL21, pRSC-GM-CSF-IL21 and pRSC were respectively transfected into the SKOV3 cells and antitumor efficacy induced by the SKOV3 cells secreting IL-21 or combination with GM-CSF was evaluated by surveying the tumor growth and the nude mice's survival. The results indicated that the secreted IL-21 and GM-CSF were functional because the culture supernatant ...

Platypus Helps Illuminate Ovarian Cancer

ScienceDaily Headlines — Sat, 27 Jun 2009 11:05:01 +0100

Researchers believe our oldest mammalian relative may help us to better understand ovarian cancer. DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer. (Source: ScienceDaily Headlines)

Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells

Nutrition and Cancer — Sat, 27 Jun 2009 10:31:13 +0100

(Source: Nutrition and Cancer)

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Platypus Link To Ovarian Cancer

Health News from Medical News Today — Sat, 27 Jun 2009 08:00:00 +0100

Researchers from the Royal Adelaide Hospital and University of Adelaide believe our oldest mammalian relative may help us to better understand ovarian cancer. University of Adelaide geneticist, Dr Frank Grutzner says DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer. (Source: Health News from Medical News Today)

New cancer treatment delivers “highly promising” results

WorldHealth.net — Fri, 26 Jun 2009 18:28:06 +0100

Five to ten percent of all breast, ovarian and prostate cancers can be attributed to mutations of the BRCA1 and BRCA2 genes. Now, for the first time, researchers have shown that a new class of drugs called PARP inhibitors may be effective in treating the diseases. In a small study, researchers from the Institute of Cancer Research gave 19 patients with inherited forms of advanced breast, ovarian and prostate cancers a PARP inhibitor called Olaparib. In 12 of those patients, none of whom had responded to any other type of treatment, their tumors either shrank or became stabilized. In addition, patients experienced very few side effects. PARP inhibitors work by targeting cancer cells, leaving healthy cells relatively untouched. Olaparib is the first drug to successfully use a technique ca...

Improvement of Survival in Sex Cord Stromal Tumors: An Observational Study With More Than 25 Years Follow-Up.

Obstetrical & Gynecological Survey — Fri, 26 Jun 2009 14:39:54 +0100

Page: 455DOI: 10.1097/01.ogx.0000351676.77800.5eAuthors: Holscher, Gabriele; Anthuber, Christoph; Bastert, Gunther; Burges, Alexander; Mayr, Doris; Oberlechner, Ernst; Schubert-Fritschle, Gabriele; Sinz, Sonja; Sommer, Harald; Schmalfeldt, Barbara; Engel, Jutta; for the Project Group "Malignant Ovarian Tumors of the Munich Cancer Center (MCC) " (Source: Obstetrical & Gynecological Survey)

The role of serum CA-125 levels in early-stage epithelial ovarian cancer on preoperative CT and MRI

European Journal of Surgical Oncology — Fri, 26 Jun 2009 14:05:42 +0100

Conclusions: Serum CA-125 levels may be very useful for the prediction of advanced-stage disease in early-stage EOC on preoperative CT and MRI. (Source: European Journal of Surgical Oncology)