MedWorm: Acanthosis Nigricans

A study of androgen and estrogen receptors α, β in skin tags

Indian Journal of Dermatology — Fri, 05 Mar 2010 14:02:58 +0100

Conclusion: </b> These results suggest the possible role of androgen and estrogen receptors in etiogenesis of skin tags, and propose that the neck is an androgen dependent area just similar to the axillae and the groins, though hairless. (Source: Indian Journal of Dermatology)

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Acanthosis Nigricans in Children With Type 2 Diabetes

Medscape Today Headlines — Tue, 16 Feb 2010 15:22:29 +0100

Can this skin finding serve as a marker for type 2 DM in children? Medscape Pediatrics (Source: Medscape Today Headlines)

Acanthosis nigricans in a patient with sarcoma of unknown origin

Journal of the American Academy of Dermatology — Tue, 16 Feb 2010 14:09:36 +0100

To the Editor: A 66-year-old man presented with a 2-month history of a slowly enlarging right axillary lymph node. Four years earlier, symmetric papillomatosis and darkening of the axillae and neck had developed (). The patient did not have diabetes and had a history of melanoma excised from his back 17 years earlier. The node was resected (); a skin biopsy specimen showed acanthosis nigricans, with acanthosis, papillomatosis, hyperkeratosis, and increased dermal pigmentation (). Histologic () and immunohistochemical analyses of the axillary node were consistent only with an unspecified sarcoma. Melanoma was excluded by immunohistochemistry. Computed tomography scans revealed metastases in multiple lymph nodes, the liver, and the spleen; the primary tumor was not found. (Source: Journal of...

Acanthosis Nigricans

Consultant Live — Thu, 04 Feb 2010 12:00:00 +0100

A 5-ft 1-in, 183-lb 14-year-old girl was concerned about the areas of thickened hyperpigmentation on her posterior neck and in her cleavage. (Source: Consultant Live)

A rare association of acanthosis nigricans with Crouzon syndrome

Indian Journal of Dermatology, Venereology and Leprology — Wed, 06 Jan 2010 14:01:46 +0100

Gupta Ajay Kumar, Koley Sankha, Choudhary Sanjiv, Bhake Arvind, Saoji Vikrant, Salodkar AtulIndian Journal of Dermatology, Venereology, and Leprology 2010 76(1):65-67 (Source: Indian Journal of Dermatology, Venereology and Leprology)

This is linear verrucous epidermal nevus, not acanthosis nigricans

Journal of Plastic, Reconstructive & Aesthetic Surgery — Mon, 28 Dec 2009 00:00:00 +0100

This is with reference to an article published in your journal, ‘Acanthosis nigricans and an alternative for its surgical therapy’, Isken T, Sen C, Iscen D, et-al, J Plast Reconstr Aesthet Surg 2009; 62: 148–150. This is to state that the clinical description and image shown in this case report is clearly that of linear verrucous epidermal nevus and not that of acanthosis nigricans. (Source: Journal of Plastic, Reconstructive & Aesthetic Surgery)

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Acanthosis Nigricans and Oral Glucose Tolerance in Obese Children

Clinical Pediatrics — Thu, 24 Dec 2009 05:44:22 +0100

(Source: Clinical Pediatrics)

Racial and Ethnic Differences in an Estimated Measure of Insulin Resistance Among Individuals with Type 1 Diabetes.

Diabetes Care — Thu, 10 Dec 2009 00:00:00 +0100

Conclusions: Minorities with type 1 diabetes are significantly more IR, as measured by eGDR, than NHW. Exploring potential mechanisms, including disparities in care and/or physiological variation, may contribute to preventing racial/ethnic differences in IR-associated outcomes. PMID: 20007942 [PubMed - as supplied by publisher] (Source: Diabetes Care)

Mediastinal lymph node metastasis of lung cancer with an unknown primary lesion having concurrent endocrine abnormality and acanthosis nigricans: report of a case.

Annals of Thoracic and Cardiovascular Surgery — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Yoshino N, Yamagishi S, Kubokura H, Mikami I, Hirata T, Koizumi K, Okano T, Futagami A, Kawamoto M, Shimizu K We herein describe a patient we encountered in whom mediastinal lymph node metastasis of lung cancer with an unknown primary lesion was complicated by both an endocrine abnormality and acanthosis nigricans. A 66-year-old male visited a local hospital and was diagnosed as having acanthosis nigricans. The patient was referred to our hospital for further examination. Computed tomography scans of the chest and the abdomen showed no adverse findings except for an enlargement of the mediastinal lymph node. No malignant lesions were detected in examinations of the upper gastrointestinal tract. Based on the above findings, the lesion was thus considered to possibly be mediasti...

Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome

International Journal of Gynaecology and Obstetrics — Thu, 26 Nov 2009 00:00:00 +0100

Conclusions: Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS. (Source: International Journal of Gynaecology and Obstetrics)

The clinical and metabolic features of Irish patients with acanthosis nigricans

Irish Journal of Medical Science — Tue, 17 Nov 2009 23:44:12 +0100

Conclusion Acanthosis nigricans in Irish subjects is associated with severe obesity and insulin resistance. The analysis highlights that subjects with acanthosis nigricans should be screened for insulin resistance and its complications. Content Type Journal ArticleCategory Poster PresentationsDOI 10.1007/BF03170260Authors S. McQuaid, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandY. Rahman, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandO. Yousif, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandD. O’Gorman, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandD. Gasparro, St James’s Hospital Metabolic Research ...

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Insulin Resistance Linked to Acanthosis Nigricans

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

SAN FRANCISCO — Insulin resistance may be present in patients with acanthosis nigricans, particularly if they are overweight or obese, and research increasingly supports a link between these conditions. (Source: Skin and Allergy News)

[Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population.]

Anales de Pediatria — Mon, 19 Oct 2009 23:00:00 +0100

CONCLUSIONS: Obesity and RI are risk factors for liver steatosis in children and adolescents. Decreased serum adiponectin is closely and independently associated with steatosis. PMID: 19850541 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

Young people with acanthosis nigricans are at high risk for Type 2 diabetes

MedWire News - Diabetes — Mon, 19 Oct 2009 13:09:47 +0100

Study results show that young people with acanthosis nigricans are at increased risk for abnormal glucose metabolism, high blood pressure, and low high-density lipoprotein cholesterol. (Source: MedWire News - Diabetes)

Hypodontia in Beare-Stevenson Syndrome: An Example of Dental Anomalies in FGFR-related Craniosynostosis Syndromes.

The Cleft Palate-Craniofacial Journal — Mon, 19 Oct 2009 00:00:00 +0100

We report a new case of Beare-Stevenson syndrome characterized by cutis gyrata, craniosynostosis, acanthosis nigricans, ear defects, a prominent umbilical stump and midface hypoplasia. He had dental findings of natal teeth and hypodontia of the primary and permanent teeth. This is the second patient with BSS syndrome to be reported with hypodontia and natal teeth; the first patient was described by Beare in 1969. We review the current literature to investigate the relation between dental anomalies and FGFR-related mutations in Beare-Stevenson syndrome and other craniosynostosis syndromes such as Apert, Crouzon and Pfeiffer. Keywords: Beare-Stevenson syndrome; cutis gyrata; craniosynostosis; dental anomalies, natal teeth; hypodontia; fibroblast growth factor receptor. PMID: 19860525 [Pu...

Acanthosis nigricans identifies young people at high metabolic risk

MedWire News - Dermatology — Fri, 09 Oct 2009 00:00:00 +0100

Presence of acanthosis nigricans identifies a population of young people at high-risk for abnormal glucose homeostasis, high blood pressure, and low high-density lipoprotein cholesterol, report researchers. (Source: MedWire News - Dermatology)

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Acanthosis Nigricans Identifies Youth at High Risk for Metabolic Abnormalities

The Journal of Pediatrics — Mon, 05 Oct 2009 00:00:00 +0100

Conclusions: Youth in the AN+ group had severe insulin resistance, and more than 1 in 4 already had abnormal glucose homeostasis. AN identified a high-risk population, for whom appropriate interventions have the potential to attenuate or even prevent the development of diabetes and further metabolic abnormalities. (Source: The Journal of Pediatrics)

Prevalence of acanthosis nigricans and its correlates in a cross-section of Nigerians with type 2 diabetes mellitus.

Tropical Doctor — Sun, 20 Sep 2009 08:46:31 +0100

This report bridges the information gap and documents the prevalence of AN in Nigerians with type 2 DM as well as its clinical correlates. Three hundred and forty consecutive subjects with type 2 DM were examined for the presence of AN and its associated clinical features. The prevalence of AN in type 2 DM in this report is 17%. Factors associated with AN include obesity, a family history of DM, female gender, the presence of hypertension and poor glycaemic control. PMID: 19762579 [PubMed - in process] (Source: Tropical Doctor)

[Skin manifestations, treatment and rehabilitation in overweight and obesity.]

Orvosi Hetilap — Fri, 04 Sep 2009 11:26:19 +0100

Authors: Wenczl E Overweight and obesity is a public health problem in Hungary and in the Western world. It is important to underline that obesity is an illness and an important risk factor for several skin and other diseases. An overview of skin diseases caused or aggravated by obesity (acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, stria, adiposis dolorosa, lymphoedema, chronic venous insufficiency, plantar hyperkeratosis, lipoedema, skin infections, acne inversa, psoriasis, tophi) helps us to look and see as well. Look for the possibility of skin infections as it helps the early diagnosis and to avoid complications. Draw patients' attention to the preventive importance of skin care. In case of an obese patient the usual dosage of most local and systemic dru...

Malignant acanthosis nigricans with enhanced expression of fibroblast growth factor receptor 3.

Acta Derm Venereol A... — Thu, 20 Aug 2009 13:32:03 +0100

Authors: Hida Y, Kubo Y, Nishio Y, Murakami S, Fukumoto D, Sayama K, Hashimoto K, Arase S PMID: 19688170 [PubMed - in process] (Source: Acta Derm Venereol A...)

Lipodystrophy: an unusual diagnosis in a case of oligomenorrhea and hirsutism.

Obstetrics and Gynecology — Fri, 24 Jul 2009 05:46:30 +0100

CONCLUSION:: Familial partial lipodystrophy, Dunnigan variety, can present with features similar to polycystic ovary syndrome. Diagnosis is critical because the metabolic complications of the disorder have significant morbidity. PMID: 19622949 [PubMed - in process] (Source: Obstetrics and Gynecology)

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Juvenile generalized acanthosis nigricans without any systemic disease

Pediatrics International — Wed, 22 Jul 2009 23:00:00 +0100

(Source: Pediatrics International)

Acanthosis Nigricans and Insulin Sensitivity in patients with Achondroplasia and Hypochodroplasia due to FGFR3 mutations.

The Journal of Clinical Endocrinology and Metabolism — Mon, 20 Jul 2009 23:00:00 +0100

Conclusion: Our findings suggest that the development of AN in patients with ACH/HCH is not due to insulin insensitivity either on its own or secondary to treatment with rhGH. Whether the acanthosis nigricans is due to altered melanocyte function in these individuals remains to be established. PMID: 19622626 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Type B insulin resistance in a systemic lupus erythematosus patient

APLAR Journal of Rheumatology — Wed, 15 Jul 2009 23:00:00 +0100

This report describes a case wherein the patient had presented with uncontrolled diabetes and required > 3000 units of human insulin to control hyperglycemia. She also had features of SLE. There was complete recovery following treatment with steroids. (Source: APLAR Journal of Rheumatology)

Malignant acanthosis nigricans with esophageal cancer

Esophagus — Wed, 17 Jun 2009 09:43:02 +0100

Abstract A 62-year-old woman was referred to our hospital with presenting pigmentation and/or dermal thickening in the nucha, face, axilla, abdomen, and hands. She also presented a history of weight loss of 4 kg during the previous 3 months. She was pathologically diagnosed as having acanthosis nigricans by skin biopsy. She subsequently underwent 18F-FDG-PET, CT, and upper gastrointestinal endoscopy, and then was diagnosed as having malignant acanthosis nigricans with squamous cell carcinoma in the esophagus at the clinical stage of T3, N0, M0, stage IIA in the UICC stage classification. She underwent subtotal esophagectomy through a left thoracotomy with thoracoabdominal two-field lymphadenectomy and esophageal reconstruction using a gastric tube through a retrosternal rou...

[Genetics] A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia

Proceedings of the National Academy of Sciences — Tue, 09 Jun 2009 04:00:00 +0100

Tre-2, BUB2, CDC16, 1 domain family member 4 (TBC1D4) (AS160) is a Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter... (Source: Proceedings of the National Academy of Sciences)

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[Miscellanea] Acanthosis nigricans

Archives of Disease in Childhood — Thu, 21 May 2009 04:00:00 +0100

(Source: Archives of Disease in Childhood)

Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population

Journal of Gastroenterology and Hepatology — Wed, 20 May 2009 04:00:00 +0100

Conclusion: The prevalence of NAFLD among adults in this urban Sri Lankan community is high and is strongly associated with constituent features of the metabolic syndrome. (Source: Journal of Gastroenterology and Hepatology)

Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: A new syndrome?

European Journal of Medical Genetics — Sun, 03 May 2009 23:00:00 +0100

We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family. PMID: 19401242 [PubMed - as supplied by publisher] (Source: European Journal of Medical Genetics)

Re: “Acanthosis nigricans and an alternative for its surgical therapy”

Journal of Plastic, Reconstructive & Aesthetic Surgery — Fri, 24 Apr 2009 09:23:35 +0100

I read with interest the article by Isket et al. describing an alternative surgical therapy for acanthosis nigricans. The authors nicely summarize the multiple variants of acanthosis nigricans, but do not specify which variant their patient had. Their patient's results after surgery appear very good. However, in my judgment, the patient's lesion appeared more consistent with an epidermal nevus rather than acanthosis nigricans. Although the authors note that their patient had received prior therapies (cryotherapy and electrosurgery) and these therapies may have altered the appearance of her condition, her lesions are not typical of acanthosis nigricans which tends to have confluent velvety hyperpigmented plaques. Instead, the figure in their article demonstrates patchy involvement with ski...

A Newborn with Acanthosis Nigricans: Can It Be Crouzon Syndrome with Acanthosis Nigricans?

Pediatric Dermatology — Fri, 17 Apr 2009 04:00:00 +0100

We present a 10-hour-old newborn who presented with bilateral choanal atresia, craniosynostosis and acanthosis nigricans. Molecular tests identified the FGFR3 Ala391Glu substitution confirming the diagnosis of CAN. Of the 35 cases of CAN reported in literature till date, only one child had acanthosis nigricans at birth. This is the first case from India to have been reported with this mutation. (Source: Pediatric Dermatology)

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Gastric diffuse large B-cell lymphoma (DLBCL) exhibiting oral acanthosis nigricans and tripe palms

Digestive and Liver Disease — Sun, 05 Apr 2009 23:00:00 +0100

Approximately one-third of non-Hodgkin lymphomas arise primarily from sites other than lymph nodes, such as spleen or bone marrow, and even from sites which normally contain no native lymphoid tissue. The extranodal lymphomas represent a challenge in routine lymphoma diagnosis, due to the variety of histological types, molecular abnormalities and clinical pictures . Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoma encountered in the gastrointestinal tract. This is mainly a disease of older adults in the seventh decade, even though it may occasionally affect children and young adults. It typically produces large, destructive lesions that may invade adjacent structures . (Source: Digestive and Liver Disease)

Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder

Annals of Diagnostic Pathology — Wed, 01 Apr 2009 04:00:00 +0100

We report on what appears to be the first case of a patient, a 48-year-old woman, with anti-Hu paraneoplastic sensory neuropathy and small cell carcinoma of the gallbladder. The patient's neurologic symptoms preceded the diagnosis of small cell carcinoma by 11 months. These symptoms improved after surgical removal of the tumor and chemotherapy. The small cell carcinoma was relatively small and was not associated with gallstones. In spite of the small size of the tumor, it metastasized to a celiac lymph node and probably to the liver. Anti-Hu paraneoplastic sensory neuropathy should be added to the list of paraneoplastic syndromes associated with small cell carcinoma of the gallbladder. (Source: Annals of Diagnostic Pathology)

Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder.

Annals of Diagnostic Pathology — Thu, 26 Mar 2009 16:41:29 +0100

Seborrhoeic keratoses in patients with internal malignancies: a case–control study with prospective accrual of patients

Journal of the European Academy of Dermatology and Venereology — Fri, 06 Mar 2009 05:00:00 +0100

Conclusion No association was found between seborrhoeic keratoses and cancer. Furthermore, our data did not provide support to the validity of the Leser-Trélat sign in patients with internal malignancies. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: A case report.

Diabetes Metab — Wed, 25 Feb 2009 05:00:00 +0100

Authors: Collet-Gaudillat C, Billon-Bancel A, Beressi JP A 54-year-old woman was referred to hospital because of poor metabolic control. Clinical examination revealed marked acanthosis nigricans, and a striking lack of adipose tissue on the limbs, and excess fat deposits on the neck and face. She had been treated for diabetes since 2001 with high doses of insulin along with metformin. Clinical tests showed hypertriglyceridaemia with low high density lipoprotein (HDL) cholesterol, and cholestasis with mild cytolysis. Dunnigan syndrome (familial partial lipodystrophy type 2) was suspected and confirmed by molecular genetics. Pioglitazone was added to her treatment, and follow-up showed improvement of metabolic control 7 months after introducing pioglitazone, and improvement of insulin se...

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Novel mutations of the BSCL2 and AGPAT2 genes in ten families with Berardinelli-Seip congenital generalized lipodystrophy syndrome.

Clinical Endocrinology — Wed, 18 Feb 2009 05:00:00 +0100

Conclusions: We demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli-Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome). PMID: 19226263 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)

Bilateral Leser-Trelat Sign Mirroring Lung Adenocarcinoma with Early Metastases to the Contralateral Lung.

Southern Medical Journal — Thu, 05 Feb 2009 08:08:38 +0100

We present a unique case of bilateral Leser-Trélat sign on the upper torso which mirrored a lung adenocarcinoma of the upper lobes.Page: 216DOI: 10.1097/SMJ.0b013e31818f604dAuthors: Dasanu, Constantin A. MD, PhD; Alexandrescu, Doru T. MD (Source: Southern Medical Journal)

Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project.

World Journal of Pediatrics : WJP — Wed, 28 Jan 2009 16:09:10 +0100

CONCLUSIONS: Results are discussed in terms of systematically defining metabolic syndrome for high-risk children, as well as public health and clinical interventions targeting children who are overweight or obese. The presence of AN and morbid obesity might be easily observed markers for metabolic syndrome. PMID: 19172328 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)

New Survey Results Show Huge Burden of Diabetes

Diabetes News from dLife.com — Mon, 26 Jan 2009 05:00:00 +0100

January 26, 2009 (NIH) - In the United States, nearly 13 percent of adults age 20 and older have diabetes, but 40 percent of them have not been diagnosed, according to epidemiologists from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), whose study includes newly available data from an Oral Glucose Tolerance Test (OGTT). Diabetes is especially common in the elderly: nearly one-third of those age 65 and older have the disease. An additional 30 percent of adults have pre-diabetes, a condition marked by elevated blood sugar that is not yet in the diabetic range. The researchers report these findings in the February 2009 issue of Diabetes Care, which posted a pre-print version of the article online at http://diabetes.org/diabetescare. The s...

Berardinelli-Seip syndrome in a 6-year-old boy

Indian Journal of Dermatology, Venereology and Leprology — Fri, 16 Jan 2009 04:12:33 +0100

Babu Priya, Sharma Rakesh, Jayaseelan Elizabeth, Appachu DivyaIndian Journal of Dermatology, Venereology and Leprology 2008 74(6):644-646A 6-year-old boy presented with abnormal habitus since birth, delayed language development, history of frequent falls since 9 months, and fever since 1 week. He was found to have hyperandrogenic features, generalized paucity of fat, generalized muscular overdevelopment, and brownish pigmentation over the flexural creases. Skin biopsy demonstrated features suggestive of acanthosis nigricans with an absence of subcutaneous tissue. After further investigation, a diagnosis of Berardinelli-Seip syndrome with bilateral pneumonia and generalized tonic clonic seizures was made. Clinical features, histopathology, differential diagnosis, and prognosis of this rare ...

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Serum and intracellular magnesium deficiency in patients with metabolic syndrome-Evidences for its relation to insulin resistance.

Diabetes Research and Clinical Practice — Sat, 03 Jan 2009 05:00:00 +0100

In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistance. PMID: 19124169 [PubMed - as supplied by publisher] (Source: Diabetes Research and Clinical Practice)

Parental diabetes, pubertal stage, and extreme obesity are the main risk factors for prediabetes in children and adolescents: a simple risk score to identify children at risk for prediabetes

Pediatric Diabetes — Thu, 18 Dec 2008 05:00:00 +0100

Conclusions: The main risk factors for prediabetes were parental diabetes, pubertal stage, and extreme obesity. Screening for prediabetes seems meaningful in subjects with either a parental history of diabetes or a combination of extreme obesity and pubertal stage and detected nearly 90% of the overweight children and adolescents with prediabetes. (Source: Pediatric Diabetes)

Prevalence of obesity and metabolic syndrome in Indigenous Australian youths

Obesity Reviews — Tue, 16 Dec 2008 05:00:00 +0100

We conducted a cross-sectional study of Indigenous youths residing in the Torres Strait region of Australia to assess the prevalence of obesity and the metabolic syndrome. Data on body mass index (BMI), waist circumference, blood pressure, presence of acanthosis nigricans and blood glucose were collected. Fasting glucose, insulin, C-Peptide, HbA1c and lipids were measured, and an oral glucose tolerance test was performed in those with a BMI greater than 25 (childhood-equivalent cut-points) or fasting glucometer reading >5.5 mmol/L. Of 158 youths, 31% were overweight and 15% were obese, 38% had enlarged waist circumference consistent with central obesity, 43% had acanthosis nigricans and 27% were hypertensive. More females than males had enlarged waist circumferences (59% vs. 13%, P < 0.001...

NOTABLE NOTES: Type 2 Segmental Acanthosis Nigricans: A Historical Case Explained by a New Concept

Archives of Dermatology — Mon, 15 Dec 2008 05:00:00 +0100

(Source: Archives of Dermatology)

Acanthosis nigricans: A practical approach to evaluation and management.

Dermatol Online J — Thu, 11 Dec 2008 05:11:09 +0100

Authors: Higgins SP, Freemark M, Prose NS Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management. PMID: 19061584 [PubMed - in process] (Source: Dermatol Online J)

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Clearance of acanthosis nigricans associated with insulinoma following surgical resection

QJM — Mon, 20 Oct 2008 04:00:00 +0100

We report a case wherein the acanthosis disappeared following surgical resection of insulinoma and this strengthens the hypothesis that hyperinsulinaemia is responsible for acanthosis. (Source: QJM)

What every physician should know about polycystic ovary syndrome

Dermatologic Therapy — Mon, 06 Oct 2008 04:00:00 +0100

ABSTRACT: Polycystic ovary syndrome (PCOS) is the most common endocrine cause of hirsutism, acne, and pattern alopecia. It is a heterogeneous syndrome of hyperandrogenic anovulation that is typically due to intrinsic ovarian dysfunction, which is often aggravated by insulin-resistant hyperinsulinemia with its risks of diabetes mellitus and metabolic syndrome and their complications. Because there are many pitfalls to androgen assays, evaluation for hyperandrogenemia is suggested in women with moderate or severe hirsutism or hirsutism equivalents, menstrual irregularity, acanthosis nigricans, or intractable obesity. An endocrinologic work-up is necessary to rule out other hyperandrogenic disorders that require specific therapy (e.g., virilizing tumors, nonclassic congenital adrenal hyperpla...

The clinical evaluation of hirsutism

Dermatologic Therapy — Mon, 06 Oct 2008 04:00:00 +0100

ABSTRACT: Hirsutism is a disorder of excess growth of terminal hairs in androgen-dependent areas in women. Other cutaneous conditions associated with androgen excess are androgenetic alopecia, acanthosis nigricans, and acne. Hirsutism is often associated with measurably elevated androgen levels, but not in all cases. Androgens in women arise from the ovary and adrenal glands, and peripherally from skin and fat. The most common cause of hirsutism is polycystic ovarian syndrome. Patients with "idiopathic" hirsutism have normal ovulatory cycles and androgen levels. Other causes are late onset congenital adrenal hyperplasia, Cushing's syndrome, and the HAIR-AN syndrome. Pituitary, ovarian, and adrenal tumors are important, but rare causes of hirsutism. A thorough history and examination are im...

Hirsutism: Clinico-investigative profile of 50 Indian patients

Indian Journal of Dermatology — Thu, 02 Oct 2008 12:01:14 +0100

Conclusion:</b> Hirsutism in Indian patients is not uncommon. Adolescent patients appear to be more concerned about hirsutism as compared to those in the older age group who were more often worried of late onset acne. All patients, however, were more concerned for facial hair than those on other body areas signifying that facial hair need to be given higher than current value in F-G score. (Source: Indian Journal of Dermatology)

Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?

European Journal of Endocrinology — Mon, 01 Sep 2008 04:00:00 +0100

CONCLUSION: This is the first report of a large pedigree with the clinical phenotype of HCH plus AN due to a FGFR3 mutation, p.Lys650Thr. This finding demonstrates the coexistence of both conditions due to the same mutation and it might represent a true complex, which should be further established by searching for AN in mild HCH patients or for HCH in patients with AN. PMID: 18583390 [PubMed - in process] (Source: European Journal of Endocrinology)

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Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity

BMC Pediatrics - Latest articles — Tue, 12 Aug 2008 04:00:00 +0100

Conclusions: Metabolic syndrome has a prevalence of 36% in children and adolescent population in the study. Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence. (Source: BMC Pediatrics - Latest articles)

Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability

American Journal of Medical Genetics Part A — Tue, 12 Aug 2008 04:00:00 +0100

We report two siblings of Hispanic origin who displayed characteristic features of CGL such as generalized loss of subcutaneous fat from birth, acanthosis nigricans, acromegaloid habitus, umbilical prominence, hepatosplenomegaly, hypoleptinemia, dyslipidemia, and insulin resistance. However, no disease causing variants were detected in the DNA sequence of AGPAT2, BSCL2 or CAV1 genes. Further, whole body magnetic resonance imaging (MRI) in the two siblings revealed marked loss of subcutaneous, intraabdominal and intrathoracic fat like in other patients with CGL, but preservation of bone marrow fat which is invariably lost in all patients with CGL1 and CGL2, but not in the patient reported with CGL3. They also had generalized muscle weakness during infancy and early childhood associated with...

Prevalence of acanthosis nigricans in relation to anthropometric measures: Community-based cross-sectional study in Korean pre-adolescent school children

Pediatrics International — Sat, 28 Jun 2008 04:00:00 +0100

Conclusions: AN has a good correlation with level of adiposity, and was already present in overweight children that were not considered obese by definition. (Source: Pediatrics International)

Abnormal venous drainage in syndromic craniosynostosis and the role of CT venography

Child's Nervous System — Wed, 25 Jun 2008 09:27:05 +0100

Conclusions Patients with syndromic craniosynostosis often demonstrate abnormal venous anatomy, which can have serious consequences on craniofacial surgery, especially when a posterior decompression is being considered. Based on these findings, the authors assert that those children with some syndromic craniosynostosis being considered for surgery should undergo venographic studies as part of their pre-operative evaluation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00381-008-0667-8Authors Dhruve Satish Jeevan, John Radcliffe Hospital Department of Paediatric Neurosurgery West Wing Level 3, Headley Way Oxford OX3 9DU UKPhillip Anlsow, John Radcliffe Hospital Department of Neuroradiology Oxford UKJayaratnam Jayamohan, John Radcliffe Hospital Depar...

Nevoid acanthosis nigricans

Indian Journal of Dermatology, Venereology and Leprology — Sat, 21 Jun 2008 20:11:14 +0100

Das Jayanta Kumar, Sengupta Sujata, Gangopadhyay AsokIndian Journal of Dermatology, Venereology and Leprology 2008 74(3):279-280 (Source: Indian Journal of Dermatology, Venereology and Leprology)

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Prevalence of acanthosis nigricans in relation to anthropometric measures: Community-based cross-sectional study in Korean pre-adolescent school children

Pediatrics International — Thu, 19 Jun 2008 12:12:12 +0100

Pediatrics International, Volume 0, Issue 0, Page ???, OnlineEarly Articles. AbstractBackground: This cross-sectional study was performed to assess the prevalence of acanthosis nigricans (AN) across various anthropometric measures and to identify the cut-offs for anthropometric indices of adiposity for development of AN in Asian ... (Source: Pediatrics International)

Nevoid acanthosis nigricans

Indian Journal of Dermatology, Venereology and Leprology — Tue, 17 Jun 2008 22:18:14 +0100

Das Jayanta Kumar, Sengupta Sujata, Gangopadhyay AsokIndian Journal of Dermatology, Venereology and Leprology 2008 74(3):281-282 (Source: Indian Journal of Dermatology, Venereology and Leprology)

ARTICLE: Primary Amenorrhea as a Manifestation of Polycystic Ovarian Syndrome in Adolescents: A Unique Subgroup?

Archives of Pediatrics — Mon, 02 Jun 2008 04:00:00 +0100

Conclusion Adolescents with PA and PCOS exhibit increased features of the metabolic syndrome and higher androstenedione levels and may represent a more severe spectrum of a common condition. (Source: Archives of Pediatrics)

Significance of acanthosis nigricans in childhood obesity

Journal of Paediatrics and Child Health — Fri, 09 May 2008 04:17:06 +0100

In this study, we aimed to find the clinical and laboratory differences in obese children with AN and without AN (non-AN). Methods: In ... (Source: Journal of Paediatrics and Child Health)

Nevoid acanthosis nigricans with subtle melanocyte hyperplasia.

Journal of the American Academy of Dermatology — Thu, 01 May 2008 04:00:00 +0100

Authors: Colegio OR, McNiff JM, Antaya RJ PMID: 18489033 [PubMed - in process] (Source: Journal of the American Academy of Dermatology)

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Acanthosis nigricans

MayoClinic.com Full Feed — Fri, 21 Mar 2008 06:00:00 +0100

— Comprehensive overview covers causes, treatment of this skin condition.Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

Insulin aspart/insulin glargine: Acanthosis nigricans: case report.

Reactions Weekly — Thu, 28 Feb 2008 08:50:47 +0100

Page: 17 (Source: Reactions Weekly)

Insulin aspart/insulin glargine: Acanthosis nigricans: case report

Reactions — Sun, 24 Feb 2008 08:27:43 +0100

(Source: Reactions)

Second case of Beare-Stevenson syndrome with an FGFR2 Ser372Cys mutation

American Journal of Medical Genetics Part A — Mon, 04 Feb 2008 05:00:00 +0100

Beare-Stevenson syndrome is characterized by cutis gyrata, acanthosis nigricans, skin furrows, skin tags, craniosynostosis, Crouzonoid-like features in some cases and cloverleaf skull in others, anogenital anomalies, and prominent umbilical stump. Reported causes are an FGFR2 Tyr375Cys mutation in nine cases and an FGFR2 Ser372Cys mutation in one case. Here, we report on a second patient with the FGFR2 Ser372Cys mutation. © 2008 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)

CORRESPONDENCE: Exogenous Insulin-Derived Acanthosis Nigricans

Archives of Dermatology — Mon, 21 Jan 2008 05:00:00 +0100

(Source: Archives of Dermatology)

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What Are the Long-term Sequelae of Dermatomyositis?

PediatricEducation.org — Mon, 14 Jan 2008 22:17:21 +0100

Discussion Juvenile dermatomyositis (JDM) is a disease causing inflammation of small vessels in multiple organs. Its etiology is unknown, but possibly is autoimmune in origin. Overall incidence is 2-3/million with females more affected than males. Over the past 40 years, there has been a marked improvement in survival (mortality is < 3%) and functionality. In one prospective study of JDM patients presenting symptoms, they had: rash (100%, i.e. heliotrope, Groton papules or malar/facial rashes often), weakness (100%), muscle pain (73%), fever (65%), dysphagia (44%), hoarseness (43%), abdominal pain (37%) and arthritis (35%). Another study found that JDM patients presenting symptoms had: rash (42-91%), fever (16%), dysphonia (24%), pulmonary problems (11%), arthritis (6%), and gastroin...

Melphalan: Acanthosis nigricans (first report) in a patient with type 2 diabetes mellitus: case report

Reactions — Mon, 10 Dec 2007 13:51:48 +0100

(Source: Reactions)

Melphalan: Acanthosis nigricans (first report) in a patient with type 2 diabetes mellitus: case report.

Reactions Weekly — Sat, 08 Dec 2007 01:46:41 +0100

Page: 24 (Source: Reactions Weekly)

The Extended Relationship between Child Cardiovascular Risks and Academic Performance Measures.

Obesity — Sat, 01 Dec 2007 05:00:00 +0100

This study expanded our understanding of the connection between children's overweight risks and academic performance by examining the impact of other cardiovascular risk factors such as high blood pressure and measures of fitness. These findings support the development and implementation of childhood cardiovascular risk surveillance programs that evaluate not only children's overweight risks but also their fitness, risk for type 2 diabetes, and/or high blood pressure by showing a relationship between some of these risks and children's academic test performance. PMID: 18198328 [PubMed - in process] (Source: Obesity)

Acanthosis Nigricans: A Common Finding in Overweight Youth

Pediatric Dermatology — Thu, 22 Nov 2007 19:18:15 +0100

Pediatric Dermatology, Volume 24, Issue 6, Page 601-606, November/December 2007. Abstract: We evaluated the prevalence of acanthosis nigricans among urban youth. Youth (7–17 years) at nine pediatric practices completed surveys on demographics and family history of diabetes and had weight and height measured. Acanthosis nigricans was ... (Source: Pediatric Dermatology)

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Epidermal manifestations of internal malignancy.

Dermatologic Clinics — Thu, 22 Nov 2007 01:36:51 +0100

Authors: Moore RL, Devere TS Paraneoplastic syndromes with cutaneous findings localized to the epidermis are discussed in this article. A paraneoplastic syndrome is a condition that arises in association with a malignancy elsewhere in the body but, in itself, is not cancerous. Generally, the onset and course of the disease will closely correlate with the malignancy, as described in Curth's original criteria for paraneoplastic syndromes, although this is not always the case. Subjects discussed include malignant acanthosis nigricans, the sign of Leser-Trélat, tripe palms, palmoplantar keratodermas, Bazex syndrome, and acquired ichthyosis. PMID: 18023768 [PubMed - in process] (Source: Dermatologic Clinics)

Obesity: Genetic, molecular, and environmental aspects

American Journal of Medical Genetics Part A — Wed, 14 Nov 2007 05:00:00 +0100

Obesity has emerged as one of the most serious public health concerns in the 21st century. Obese children tend to become obese adults. The dramatic rise in pediatric obesity closely parallels the rapid increase in the prevalence of adult obesity. As overweight children become adults they face the multitude of health problems associated with obesity at younger ages. The morbidity and mortality associated with obesity continue to increase. Obesity is one of the leading causes of preventable death. Complications of obesity include cardiovascular risks, hypertension, dyslipidemia, endothelial dysfunction, type 2 diabetes mellitus and impaired glucose tolerance, acanthosis nigricans, hepatic steatosis, premature puberty, hypogonadism and polycystic ovary syndrome, obstructive sleep disorder, or...

The heterozygous LMNA mutation p.R471G causes a variable phenotype with features of two types of familial partial lipodystrophy

American Journal of Medical Genetics Part A — Fri, 09 Nov 2007 05:00:00 +0100

We report on a novel LMNA mutation (p.R471G) in a proband affected by a syndrome comprising partial lipodystrophy, insulin-resistant diabetes, acanthosis nigricans, liver steatosis, muscle weakness, and contractures. This phenotype has features of both types 1 and 2 familial partial lipodystrophy. The sister and father of the proband had the same mutation. The sister was more mildly affected and the father was apparently unaffected, demonstrating variable expressivity and reduced penetrance for this mutation. © 2007 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)

Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report.

Diabetes and Metabolism — Thu, 11 Oct 2007 04:00:00 +0100

We report a very rapid and good efficacy of pioglitazone added to metformin without side effects in FPLD2. If confirmed on more patients, early use of pioglitazone in association with metformin could be proposed in FPLD2. PMID: 17936664 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)

Über einen Fall von Papillomatosis papulosa confluens et tumoriformis (Acanthosis nigricans)

Archives of Dermatological Research — Fri, 05 Oct 2007 15:55:48 +0100

Content Type Journal ArticleDOI 10.1007/BF02718858Authors Janis Brants, Aus dem Staatlichen Krankenhaus Aleksandra Augstumi Riga Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696 Journal Volume Volume 185 Journal Issue Volume 185, Number 2 / June, 1944 (Source: Archives of Dermatological Research)

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The presence of family history and the development of type 2 diabetes mellitus risk factors in rural children.

The Journal of School Nursing — Mon, 01 Oct 2007 04:00:00 +0100

This study identified selected risk factors (i.e., high-risk racial/ethnic group, obesity, elevated blood pressure, elevated casual blood glucose, elevated total cholesterol, and the presence of acanthosis nigricans) for development of type 2 diabetes mellitus in rural children with or without a family history of diabetes during annual school health fairs. Of the children screened, 40% (673) presented with two or more of the identified risk factors for type 2 diabetes mellitus. The presence of multiple risk factors in participants reporting a positive family history of diabetes mellitus versus those with no family history was not statistically significant. Based on the study results, factors other than family history may be more predictive for the development of type 2 diabetes mellitus in...

Is Acanthosis Nigricans a reliable indicator for risk of type 2 diabetes?

The Journal of School Nursing — Mon, 01 Oct 2007 04:00:00 +0100

This article will explore the controversy associated with screening for AN and make recommendations for school nursing practice. PMID: 17894521 [PubMed - indexed for MEDLINE] (Source: The Journal of School Nursing)

OBSERVATION: Familial Acanthosis Nigricans Due to K650T FGFR3 Mutation

Archives of Dermatology — Mon, 17 Sep 2007 04:00:00 +0100

Conclusion Extensive acanthosis nigricans in early childhood, especially with a family history of acanthosis nigricans, may warrant testing for FGFR3 mutations. (Source: Archives of Dermatology)

Crouzon with acanthosis nigricans. Further delineation of the syndrome

Clinical Genetics — Mon, 03 Sep 2007 03:00:43 +0100

Clinical Genetics Volume 0, Issue 0, Page ???-???. Arnaud-López L, Fragoso R, Mantilla-Capacho J, Barros-Núñez P. Crouzon with acanthosis nigricans. Further delineation of the syndrome.Clin Genet 2007. © Blackwell Munksgaard, 2007Patients with Crouzon and acanthosis nigricans syndrome show craniofacial fea... (Source: Clinical Genetics)

Management of type 2 diabetes in youth: an update.

American Family Physician — Sat, 01 Sep 2007 04:00:00 +0100

This article is an update from the National Diabetes Education Program on the management of type 2 diabetes in youth. High-risk youths older than 10 years have a body mass index greater than the 85th percentile for age and sex plus two additional risk factors (i.e., family history, high-risk ethnicity, acanthosis nigricans, polycystic ovary syndrome, hypertension, or dyslipidemia). Reducing overweight and impaired glucose tolerance with increased physical activity and healthier eating habits may help prevent or delay the development of type 2 diabetes in high-risk youths. The American Academy of Pediatrics does not recommend population-based screening of high-risk youths; however, physicians should closely monitor these patients because early diagnosis may be beneficial. The American Diabe...

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IMAGES IN CLINICAL MEDICINE: Oral Acanthosis Nigricans

New England Journal of Medicine — Wed, 29 Aug 2007 04:00:00 +0100

A 44-year-old woman presented with increasing oral papillomatosis, predominantly on the lips and less pronounced on the tongue and buccal mucosa. The lips showed filiform papillomas in a symmetrical distribution ... (Source: New England Journal of Medicine)

Adipose tissue and liver lipid metabolism in obese children: role of the body mass index and the presence of acanthosis nigricans

Diabetic Medicine — Fri, 24 Aug 2007 08:12:06 +0100

Diabetic Medicine Volume 0, Issue 0, Page ???-???. Abstract Aims The aims of our study were to determine if insulin resistance is associated with increased plasma levels of non-esterified fatty acids (NEFA), glycerol, 3-hydroxybutyrate and triglycerides in obese children. We also studied whether the pres... (Source: Diabetic Medicine)

Familial acanthosis nigricans showing ichthyosiform skin lesions in two sisters

The Journal of Dermatology — Thu, 23 Aug 2007 09:34:00 +0100

The Journal of Dermatology Volume 34, Issue 9, Page 680-681, Sep 2007. (Source: The Journal of Dermatology)

Palifermin: First report of acanthosis nigricans: case report

Reactions — Sun, 22 Jul 2007 12:12:46 +0100

(Source: Reactions)

Palifermin: First report of acanthosis nigricans: case report.

Reactions Weekly — Sun, 22 Jul 2007 00:48:50 +0100

Page: 20 (Source: Reactions Weekly)

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Annals Of Family Medicine

IT / Internet / E-mail News From Medical News Today — Sun, 10 Jun 2007 15:00:00 +0100

SKIN CONDITION CAN HELP IDENTIFY HIGH-RISK FOR DIABETES An easily identifiable dermatologic condition, acanthosis nigricans, is associated with having multiple risk factors for type 2 diabetes, in patients aged 7 to 39 years, finds this study of 1,113 patients. As the number of type 2 diabetes risk factors increased, so did the prevalence of acanthosis nigricans in both children and adults. [click link for full article] (Source: IT / Internet / E-mail News From Medical News Today)

Acanthosis Nigricans May Be a Risk Factor for Type 2 Diabetes

Medscape PublicHealth Headlines — Fri, 08 Jun 2007 16:00:00 +0100

A study showed that patients with acanthosis nigricans are likely to have multiple risk factors for type 2 diabetes, allowing clinicians to more rapidly identify and counsel high-risk individuals. (CME)Medscape Medical News (Source: Medscape PublicHealth Headlines)

Skin Condition IDs Type 2 Diabetes

WebMD Health — Mon, 04 Jun 2007 05:00:00 +0100

People with acanthosis nigricans -- velvety patches of dark skin usually on the back of the neck -- are at high risk of type 2 diabetes, researchers say. (Source: WebMD Health)

Palifermin-induced acanthosis nigricans

Internal Medicine Journal — Fri, 25 May 2007 05:52:01 +0100

Internal Medicine Journal Volume 37, Issue 6, Page 417-418, Jun 2007. (Source: Internal Medicine Journal)

Acanthosis nigricans and diabetes risk factors: prevalence in young persons seen in southwestern US primary care practices.

Annals of Family Medicine — Tue, 01 May 2007 04:00:00 +0100

CONCLUSIONS: Patients with acanthosis nigricans are likely to have multiple risk factors for type 2 diabetes. Acanthosis nigricans may be an independent risk factor for this disease. Detection of acanthosis nigricans may help clinicians more rapidly identify high-risk individuals for diabetes counseling. PMID: 17548847 [PubMed - indexed for MEDLINE] (Source: Annals of Family Medicine)

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The First Korean Case of Beare-Stevenson Syndrome with a Tyr375Cys Mutation in the Fibroblast Growth Factor Receptor 2 Gene.

J Korean Med Sci — Sun, 01 Apr 2007 04:00:00 +0100

Authors: Eun SH, Ha KS, Je BK, Lee ES, Choi BM, Lee JH, Eun BL, Yoo KH Here we report the first case of a Korean infant with a cloverleaf-shaped craniosynostosis, in which the diagnosis of Beare-Stevenson syndrome was suspected upon observation of the typical morphological features. This infant exhibited craniofacial anomalies, ocular proptosis, cutis gyrata, acanthosis nigricans, prominent umbilical stump, furrowed palms and soles, hypospadia, and sacral skin tag coupled with dermal sinus tract. Brain magnetic resonance imaging revealed that the patient also had non-communicating hydrocephalus with Chiari malformation. This is the 8th report of Beare-Stevenson syndrome in the literature, which was confirmed by the detection of a Tyr375Cys mutation in the fibroblast growth factor recep...

[Primary lipodystrophies]

Annales d'Endocrinologie — Thu, 01 Feb 2007 05:00:00 +0100

Authors: Capeau J, Magré J, Lascols O, Caron M, Béréziat V, Vigouroux C Primary lipodystrophies represent a heterogeneous group of very rare diseases with a prevalence of less than 1 case for 100.000, inherited or acquired, caracterized by a loss of body fat either generalized or localized (lipoatrophy). In some forms, lipoatrophy is associated with a selective hypertrophy of other fat depots. Clinical signs of insulin resistance are often present: acanthosis nigricans, signs of hyperandrogenism. All lipodystrophies are associated with dysmetabolic alterations with insulin resistance, altered glucose tolerance or diabetes and hypertriglyceridemia leading to a risk of acute pancreatitis. Chronic complications are those resulting from diabetes involving the retina, kidney ...

A clinical approach to severe insulin resistance.

Endocrine Development — Mon, 01 Jan 2007 05:00:00 +0100

Authors: Savage DB, Semple RK, Chatterjee VK, Wales JK, Ross RJ, O'Rahilly S Extreme forms of insulin resistance are a rare cause of type 2 diabetes. However, individuals with severe insulin resistance pose unique diagnostic and therapeutic challenges, and have often acted as 'experiments of nature' providing important novel information regarding endocrine physiology and mechanistic insights relevant to the study of more common disorders. Progress in understanding the molecular pathogenesis of such syndromes is also beginning to yield novel therapeutic options. Severe insulin resistance typically presents in 1 of 3 ways: (1) disordered glucose metabolism including both diabetes and/or paradoxical hypoglycaemia; (2) acanthosis nigricans, a velvety hyperpigmentation of axilliary and flex...

Paraneoplastic type of acanthosis nigricans in patient with hepatocellular carcinoma.

Advances in Medical Sciences — Mon, 01 Jan 2007 05:00:00 +0100

CONCLUSIONS: Paraneoplastic type of acanthosis nigricans--in patient with hepatocellular carcinoma is not frequently reported in the literature. In the aspect of clinical occurrence of skin lesions suggesting acanthosis nigricans the diagnostics should be focused on internal malignancies. PMID: 18217428 [PubMed - indexed for MEDLINE] (Source: Advances in Medical Sciences)

The changing spectrum of diabetes in Mexican American youth

Reviews in Endocrine & Metabolic Disorders — Fri, 29 Dec 2006 07:57:27 +0100

Abstract??Type 2 diabetes (T2DM) is now a pediatric disease. As in adults, it disproportionately affects ethnic and racial minorities, including Hispanics. The preponderance of Hispanics in south Texas are of Mexican American (MA) heritage. Over the past 16?years, we have accumulated a large cohort of children with diabetes. We have noted distinct differences in numerous parameters between MA children with T2DM and those with type 1 diabetes (T1DM). In order to explore these observations, we have reviewed the records of all children diagnosed with diabetes (n?=?669) during the 9?years between January, 1990 and December, 1998 and seen by our pediatric diabetes group. In this cohort were 329 MA, 287 non-Hispanic whites (EA) and 53 African Americans. Compared to EA children with T1DM, MA chil...

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High blood pressure in school children: prevalence and risk factors

BioMed Central — Thu, 16 Nov 2006 07:00:00 +0100

Conclusions: Twenty one percent of school children had HBP, especially the prevalence was higher among the overweight and Hispanic group. The association identified here can be used as independent markers for increased likelihood of HBP in children. (Source: BioMed Central)

Generalized acanthosis nigricans in childhood.

Dermatol Online J — Wed, 08 Nov 2006 15:36:04 +0100

We report a 13-year-old boy with an 8-year history of generalized hyperpigmentation and velvety thickening of the skin. Despite an extensive physical and laboratory examination no evidence of underlying endocrinological or neoplastic disease was found. PMID: 17083894 [PubMed - in process] (Source: Dermatol Online J)

Navigating Adolescence with a Chronic Health Condition: A Perspective on the Psychological Effects of HAIR-AN Syndrome on Adolescent Girls

TheScientificWorldJOURNAL: Newly published articles. — Tue, 24 Oct 2006 16:29:02 +0100

HAIR-AN syndrome is a subphenotype of polycystic ovary syndrome and is characterized by acne, obesity, hirsutism, and acanthosis nigricans. It usually manifests in early adolescence, a time of significant developmental change in females across physical, cognitive, social, and emotional domains. We contend that adolescent development for females is difficult, even in the best of circumstances, and having a chronic health condition, like HAIR-AN syndrome, will likely impact the afflicted individual’s development and psychological well-being. While many researchers have discussed the long-term health effects of HAIR-AN and similar disorders, little has been written about the potential psychological sequelae of HAIR-AN on the adolescent girl. We discuss the normal developmental sequence for ...

Acanthosis nigricans in an HIV seropositive: Is there a correlation?

Indian Journal of Dermatology, Venereology and Leprology — Mon, 09 Oct 2006 22:13:04 +0100

Marfatia YS, Sharma ArchanaIndian Journal of Dermatology, Venereology and Leprology 2006 72(5):383-384 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Marked insulin resistance in pregnancy: a case report and literature review.

Tennessee Medicine — Sun, 01 Oct 2006 04:00:00 +0100

We report a case of a 14-year-old with acanthosis nigricans and a strong family history of Type 2 diabetes who exhibited marked insulin resistance during pregnancy. Her treatment included terbutaline for pre-term labor and dexamethasone for fetal lung maturity. Shortly after these interventions, her insulin requirements escalated to 130 units per hour. Multiple insulin regimens were used in her treatment. Investigations were negative for antinuclear antibodies, islet cell IgG auto-antibodies (GAD65 Antibody assay) and insulin antibodies. Her thyroid-stimulating hormone was within normal limits and her C-peptide level elevated at 18 ng/dL [1.1-4.8 ng/L]. A week following cessation of the dexamethasone and terbutaline, her insulin requirements dramatically decreased. We conclude that in preg...

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Mosaicism of activatingFGFR3 mutations in human skin causes epidermal nevi

Journal of Clinical Investigation — Tue, 01 Aug 2006 06:00:00 +0100

Epidermal nevi are common congenital skin lesions with an incidence of 1 in 1,000 people; however, their genetic basis remains elusive. Germline mutations of the FGF receptor 3 (FGFR3) cause autosomal dominant skeletal disorders such as achondroplasia and thanatophoric dysplasia, which can be associated with acanthosis nigricans of the skin. Acanthosis nigricans and common epidermal nevi of the nonorganoid, nonepidermolytic type share some clinical and histological features. We used a SNaPshot multiplex assay to screen 39 epidermal nevi of this type of 33 patients for 11 activating FGFR3 point mutations. In addition, exon 19 of FGFR3 was directly sequenced. We identified activating FGFR3 mutations, almost exclusively at codon 248 (R248C), in 11 of 33 (33%) patients with nonorganoid, nonepi...

Influence of skin color on the diagnostic utility of clinical acanthosis nigricans to predict insulin resistance in obese patients.

Archives of Medical Research — Tue, 01 Aug 2006 06:00:00 +0100

CONCLUSIONS: People with skin phototype IV have a high frequency of AN on the neck, compared with those with phototypes II and III. Those with AN and skin phototype II showed high specificity and positive predictive values for insulin resistance. Thus, AN is a good marker for IR only in lower phototypes. PMID: 16824934 [PubMed - indexed for MEDLINE] (Source: Archives of Medical Research)

Screening for Type 2 Diabetes in Children With Acanthosis Nigricans

The Diabetes Educator — Thu, 27 Jul 2006 06:00:00 +0100

Acanthosis nigricans is a physical finding of the skin that appears to be a marker for insulin resistance. Because of the association of insulin resistance and type 2 diabetes, acanthosis nigricans may also be a marker for type 2 diabetes. Some states have recommended statewide screening for acanthosis nigricans. However, this has led to a large referral of children to pediatric endocrinologists. Presented is a schema for primary care physicians and school nurses to use as a guideline for referral of children with acanthosis nigricans. (Source: The Diabetes Educator)

Dermatology of androgen-related disorders.

Clinics in Dermatology — Sat, 01 Jul 2006 04:00:00 +0100

Authors: Essah PA, Wickham EP, Nunley JR, Nestler JE Hyperandrogenism in women can be caused by various conditions, the most prevalent of which is polycystic ovary syndrome. Common dermatologic manifestations of hyperandrogenism include hirsutism, acne, acanthosis nigricans, and androgenic alopecia. Hirsute women often have increased activity of 5 alpha-reductase, the enzyme that converts the androgen testosterone to its active metabolite, in hair follicles. Likewise, androgens affect the formation of acne by increasing sebum production from sebaceous glands in the skin. The diagnosis of polycystic ovary syndrome includes a complete history, physical examination with emphasis on evidence of androgen excess, and appropriate laboratory investigation to exclude other causes of hyperandrog...

Skin manifestations in acromegaly.

Clinics in Dermatology — Sat, 01 Jul 2006 04:00:00 +0100

Authors: Ben-Shlomo A, Melmed S Cutaneous changes in acromegaly result from excess GH and IGF-1 action on skin cells and adnexae. Skin puffiness due to dermal glycosaminoglycan accumulation and edema are most prominent in the face, hands and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered. Alteration in skin capillaries produce increased vasoconstriction. Discerning these changes contributes to early diagnosis and treatment of this high-morbidity disorder. Controlling GH and IGF-1 over-secretion alleviates most cutaneous manifestations of acromegaly; however, regression may be incomplete. PMID: 16828406 [PubMed - indexed for MEDLINE] (Source: Clinics in Dermat...

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Diabetes mellitus.

Clinics in Dermatology — Sat, 01 Jul 2006 04:00:00 +0100

Authors: Ahmed I, Goldstein B Dermatologic problems are common in diabetes, with approximately 30% of patients experiencing some cutaneous involvement during the course of their illness. Skin manifestations generally appear during the course of the disease in patients known to have diabetes, but they may also be the first presenting sign of diabetes or even precede the diagnosis by many years. The skin involvement can be autoimmune in nature, such as acanthosis nigricans, necrobiosis lipoidica, diabetic dermopathy, scleredema, and granuloma annulare, or infectious in the form of erythrasma, necrotizing fasciitis, and mucormycosis. Pharmacologic management of diabetes, in addition, can also result in skin changes, such as lipoatrophy and lipohypertrophy, at the site of injection of insu...

Acanthosis nigricans: Clinical predictor of abnormal glucose tolerance in Asian women with polycystic ovary syndrome

Gynecological Endocrinology — Mon, 29 May 2006 06:00:00 +0100

(Source: Gynecological Endocrinology)

Nevoid acanthosis nigricans localized to the umbilicus

The Journal of Dermatology — Mon, 15 May 2006 08:51:09 +0100

The Journal of Dermatology Volume 33, Issue 6, Page 433-434, Jun 2006 (Source: The Journal of Dermatology)

Genetic basis of lipodystrophies and management of metabolic complications.

Annual Review of Medicine — Sun, 01 Jan 2006 05:00:00 +0100

Authors: Agarwal AK, Garg A Selective loss of body fat is the hallmark of patients with lipodystrophies. Among genetic lipodystrophies, fat loss is observed either from birth, as in congenital generalized lipodystrophy, or later in life, as in familial partial lipodystrophy. The extent of fat loss also varies among subtypes of lipodystrophies. Patients develop hyperinsulinemia, acanthosis nigricans, hypertriglyceridemia, diabetes mellitus, and hepatic steatosis. Defects in several genes, such as those encoding an enzyme (AGPAT2), a nuclear receptor (PPARgamma), a nuclear lamina protein (LMNA) and its processing endoprotease (ZMPSTE24), a kinase (AKT2), and a protein of unknown function (BSCL2), have been found in patients with genetic lipodystrophies. Additional loci remain to be disco...

Classification of diabetes in young adults: new concepts for an old disease.

Diabetes Metab — Wed, 14 Dec 2005 07:00:00 +0100

We present two clinical observations which both illustrate the insufficiencies of the present classifications. Modern tools are now available for diagnosis such as anti-GAD65 and IA-2 antibodies, genetic tools to investigate for specific mutations, but quantitative means of beta cell mass are lacking. Clinical examination is still accurate to identify type 1 or type 2 diabetes, MODY and mitochondrial diabetes. Weight curve, lesions of acanthosis nigricans, criteria of metabolic syndrome, history of diabetes are critical factors. This problematic has important consequences in our daily practice: the right choice for rapid and good metabolic control. PMID: 16357809 [PubMed - indexed for MEDLINE] (Source: Diabetes Metab)

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Insulin resistance in adolescents with Down syndrome: a cross-sectional study

BMC Endocrine Disorders — Fri, 17 Jun 2005 06:00:00 +0100

Conclusion: The obese and overweight, female and adult patients showed the highest values of HOMA and insulin. (Source: BMC Endocrine Disorders)