MedWorm: Acanthosis Nigricans

Insulin/insulin suspension isophane: Acanthosis nigricans in an elderly patient: case report

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

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Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with acanthosis nigricans in obese adolescents

Diabetic Medicine — Mon, 30 Jan 2012 05:00:00 +0100

Conclusions: While acanthosis nigricans is undoubtedly associated with insulin resistance, its appearance is not ubiquitous in patients at any given level of HOMA‐IR. The higher levels of pigment epithelium‐derived factor in those with acanthosis nigricans compared with those without, with similar levels of resistance, suggest that pigment epithelium‐derived factor levels are associated with acanthosis nigricans.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

A study of pathogenesis of Acanthosis nigricans and its clinical implications

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Discussion: In our study, the flexural involvement (flexures of groins, knees and elbows) was seen in 40% patients, lip involvement was seen in 6.6% patients, and dorsal involvement was seen in 3.3% patients each. Increased serum testosterone levels were seen in 13.3% patients and increased DHEAS levels were seen in 20% patients. Regarding the types of AN, obesity induced AN or pseudo-AN was seen 70% patients, syndromic AN was seen in 23.35% patients and malignant AN was seen in 6.6% patients. The commonest histopathological feature of patients with AN was hyperkeratosis, seen in 100% patients, papillomatosis was seen in 90% patients, dermal infiltrate of lymphocytes and plasma cells was seen in 60% patients, horn...

Acanthosis nigricans associated with transitional cell carcinoma of the urinary bladder

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Gautam K Singh, Debraj Sen, DS Mulajker, MS SureshIndian Journal of Dermatology 2011 56(6):722-725An elderly man from the region of Ladakh presented with recurrent episodes of lower respiratory tract infection, rapidly progressive Acanthosis nigricans, Acanthosis palmaris and plantar keratoderma. Detailed investigations revealed underlying metastatic transitional cell carcinoma of the bladder. This case is being reported for its rarity in the literature. (Source: Indian Journal of Dermatology)

Is Acanthosis Nigricans a Reliable Indicator for Risk of Type 2 Diabetes in Obese Children and Adolescents? A Systematic Review.

The Journal of School Nursing — Fri, 16 Dec 2011 05:00:00 +0100

This article reviews the current literature examining the association between the presence of acanthosis nigricans (AN) and risk for developing type 2 diabetes mellitus (T2DM) in obese children and adolescents. Ethnicity, family history of diabetes, and emergence of obesity are contributing factors for development of hyperinsulinemia, and insulin resistance, and ensuing visible changes on skin which is known as the AN. The purpose of this review was to assess the validity of AN as an early indicator of T2DM. Nineteen articles that were published from 1994 to 2010 were included for this review and reported an association between AN, hyperinsulinemia, and hyperglycemia. Nurses and advanced nurse practitioners working with children and adolescents have a tremendous role in identifying the ris...

Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism

European Journal of Clinical Investigation — Thu, 08 Dec 2011 06:48:23 +0100

Conclusions A number of patients presenting with hirsutism and exhibiting similar features to PCOS may have other underlying diagnoses. Unlike PCOS, some of these disorders can occasionally be life threatening and require prompt diagnosis and treatment. (Source: European Journal of Clinical Investigation)

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Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents.

Endokrynologia Polska — Wed, 07 Dec 2011 15:12:02 +0100

Conclusion: Our study confirms that obesity is a risk factor for vitamin D deficiency. Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance. (Pol J Endocrinol 2011; 62 (6): 506-511). PMID: 22144216 [PubMed - in process] (Source: Endokrynologia Polska)

A Longitudinal Study of Overweight, Elevated Blood Pressure, and Acanthosis Nigricans Among Low-Income Middle School Students.

The Journal of School Nursing — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Kopping D, Nevarez H, Goto K, Morgan I, Frigaard M, Wolff C Abstract This longitudinal study examined the rates of overweight, elevated blood pressure, acanthosis nigricans, and their associated factors in third through fifth grade students over 4 years. Participants consisted of 279 students who participated in health screenings in 2002 and 2006. Hispanic students had significantly higher rates of overweight and acanthosis nigricans compared to White students. There was a sharp increase in elevated blood pressure from 2002 to 2006 among obese children. While 20% of the matched obese students were above the 90th percentile in 2002, 82% of the same students were above the 90th percentile in 2006. After controlling for sex, ethnicity, and grade, preadolescent obesity in 2002...

Dermatological Phenotype in Costello Syndrome: Consequences of Ras Dysregulation in Development

British Journal of Dermatology — Sat, 19 Nov 2011 05:00:00 +0100

Conclusions: While there is significant phenotypic overlap among syndromes of the Ras/MAPK pathway, individuals with CS are more likely than individuals with CFC syndrome to present with cutaneous papillomas, palmoplantar keratoderma and full eyebrows, and are less likely to present with ulerythema ophryogenes, keratosis pilaris or multiple naevi. The dermatologic features of CS, a Ras dysregulation syndrome, share many features with cutaneous paraneoplastic syndromes. This may provide further insight into the role of Ras signaling in cutaneous paraneoplastic syndromes. (Source: British Journal of Dermatology)

Dermatological Phenotype in Costello Syndrome: Consequences of Ras Dysregulation in Development.

The British Journal of Dermatology — Sat, 19 Nov 2011 05:00:00 +0100

Effects of ethinyl estradiol and desogestrel on clinical and metabolic parameters in Indian patients with polycystic ovary syndrome

Journal of Obstetrics and Gynaecology Research — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion: Significant improvements in hyperandrogenic parameters were seen only in the first 6 months of treatment with EE/DSG in PCOS. Further continuation with this pill did not produce any significant improvement. There were no adverse effects on insulin sensitivity. (Source: Journal of Obstetrics and Gynaecology Research)

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Acanthosis nigricans in the setting of niacin therapy.

Dermatol Online J — Tue, 08 Nov 2011 04:35:03 +0100

We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia. Although obesity and insulin-resistance are risk factors for AN, AN associated with endocrine dysfunction tends to have a more gradual onset and limited involvement. Owing to our patient's age, the rapid onset, and extensive distribution of his eruption, we initially were concerned about paraneoplastic AN. However, an evaluation for a malignant condition was negative. The timing of the onset of our patient's eruption within several months of starting niacin therapy is consistent with niacin-induced AN. Niacin is known to cause rapidly progressive, widespread AN that is reversible upon discontinuation of ...

Sixteen years and counting: The current understanding of Fibroblast Growth Factor Receptor 3 (FGFR3) signaling in skeletal dysplasias

Human Mutation — Tue, 01 Nov 2011 04:00:00 +0100

This article describes the challenging journey to unravel the mechanisms of FGFR3 function in skeletal dysplasias, the extraordinary cellular manifestations of FGFR3 signaling in chondrocytes, and finally, the progress toward therapy for ACH and cancer. ©2011 Wiley Periodicals, Inc. (Source: Human Mutation)

Mild isolated craniosynostosis due to a novel FGFR3 mutation, p.Ala334Thr

American Journal of Medical Genetics Part A — Fri, 28 Oct 2011 04:00:00 +0100

AbstractCraniosynostosis is the premature fusion of one or more sutures of the skull, which can be syndromic or isolated. Mutations in FGFR1, FGFR2, or FGFR3, among others, are often responsible for these syndromic cases. The associated of FGFR3 mutations with craniosynostosis has been restricted to three mutations, the common p.Pro250Arg in Muenke syndrome, p.Ala391Glu in Crouzon syndrome with acanthosis nigricans, and p.Pro250Leu identified in a family with isolated craniosynostosis. Other FGFR3 mutations result in various skeletal dysplasias: achondroplasia, hypochondroplasia, and thanatophoric dysplasia. Here, we report a novel mutation in exon 8 (IIIc) of FGFR3, p.Ala334Thr, in a young boy with mild craniosynostosis. The mutation segregated with mild craniosynostosis in the family and...

Acanthosis Nigricans as a Clinical Marker to Detect Insulin Resistance in Caucasian Children From West Virginia

Clinical Pediatrics — Tue, 18 Oct 2011 04:00:00 +0100

The accuracy of acanthosis nigrcans (AN) as a dermatological clinical marker to predict insulin resistance (IR) has not been well established in children. A cohort of obese Caucasian children was prospectively recruited. Demographic data, body mass index values, and laboratory data were compared for the presence or absence of AN. A total of 76 children participated. In all, 46 (60.5%) children had AN, and 34 (44.7%) children were positive for IR (>3.16); 25 (32.9%) children were positive for both AN and IR. Sensitivity, specificity, positive and negative predictive values, and accuracy level for AN to detect IR in the obese children who participated in this study were 73.5%, 50%, 54.3%, 70%, and 49%, respectively. The correlation between insulin and fasting glucose levels in AN-negative...

Oral acanthosis nigricans in chronic hepatitis B with a 21‐year follow up

The Journal of Dermatology — Tue, 04 Oct 2011 04:00:00 +0100

AbstractAcanthosis nigricans is a rare mucocutaneous disorder of unknown etiology that manifests as hyperpigmented velvety plaques, most often on intertriginous areas such as the neck and axillae as well as on mucosal sites such as the oral cavity. The disorder presents either as a paraneoplastic manifestation of an underlying malignancy, especially gastrointestinal adenocarcinomas or in association with obesity, administration of drugs or endocrinopathies, most commonly insulin‐resistant diabetes mellitus. In the present article, a case of acanthosis nigricans with oral and cutaneous manifestations in a male patient with chronic hepatitis B infection is described. To the best of our knowledge, this is the first case of benign oral acanthosis nigricans associated with chronic hepatitis B...

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Prevalence of insulin resistance and impaired glucose tolerance in a sample of obese spanish children and adolescents

Endocrine — Sat, 01 Oct 2011 05:48:56 +0100

Abstract The prevalence of obesity in children has increased in developed countries in the last decades. It is associated with alterations in glucose metabolism that may be present in childhood. To assess the frequency of glucose metabolism alterations and insulin resistance and their possible determinants in a sample of obese children from Valladolid (Spain), we retrospectively studied 100 obese children and adolescents (11.59 ± 2.73 years). Anthropometric measures, biochemical parameters, and oral glucose tolerance test (OGTT) were performed. Insulin resistance was evaluated with fasting insulin, HOMA index, and insulin values in OGTT. Impaired glucose tolerance was found in 15% of the sample, and was the most frequent of glucose metabolism alterations. I...

[Tripe palms and a hypertrophic osteoarthropathy syndrome revealing a neuroendocrine carcinoma of the lung].

Annales de Dermatologie et de Cenereologie — Sat, 01 Oct 2011 04:00:00 +0100

Authors: El Bakkal A, Idrissi R, Meziane M, Mikou O, Sekal M, Belghiti H, Bennani A, Znati K, Amarti A, Karkos F, Amara B, El Biaze M, Benjelloun MC, Brahmi S, Elmesbahi O, Mernissi FZ Abstract BACKGROUND: Tripe palms is a rare cutaneous paraneoplastic syndrome, primarily evocative of lung and gastric neoplasia. Association of many paraneoplastic diseases has also been reported. PATIENTS AND METHODS: A 49-year-old man with a history of alcoholism and smoking addiction reported haemoptysis and thoracic pains present for one year. The physical examination showed left lung condensation. The skin examination revealed a thickened yellowish keratoderma with exaggerated skin ridges and digital clubbing. A diagnosis of paraneoplastic tripe palms was made, prompting repetition of the bi...

Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population.

Nutricion Hospitalaria — Sat, 01 Oct 2011 04:00:00 +0100

Conclusion: To detect acanthosis nigricans in Chilean population may be effective for the early diagnose of insulin resistance and, therefore, reduce the associated cost of the late treatment of glucose metabolic disturbances. PMID: 22072335 [PubMed - in process] (Source: Nutricion Hospitalaria)

Noninsulin-dependent, type II diabetes mellitus-related dermatoses: part II.

Skinmed — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Sehgal VN, Srivastava G, Aggarwal AK, Gupta M, Bhattacharya SN, Verma P Abstract Cutaneous complications of noninsulin-dependent, type II diabetes mellitus are reviewed, including diabetic dermopathy, necrobiosis lipoidica diabeticorum, diabetic bullae (bullosis diabeticorum), certain acquired perforating dermatoses, diabetic thick skin, scleredema adultorum, Dupuytren's contractures, certain xanthomas, carotenoderma, rubeosis faciei, and acanthosis nigricans. PMID: 22165045 [PubMed - in process] (Source: Skinmed)

Cutaneous paraneoplasia

Clinics in Dermatology — Sat, 20 Aug 2011 15:44:24 +0100

Abstract: Paraneoplasias are frequently the first sign of a subjacent malignant tumor. Although relatively rare, they need to be recognized by dermatologists to make an early diagnosis and improve the prognosis related especially to the neoplasia. This contribution presents the morphologic aspects and the differential diagnosis of the main paraneoplasias, which include acanthosis nigricans, tripe palms, Leser-Trélat sign, acquired ichthyosis, acquired hypertrichosis lanuginosa, pityriasis rotunda, erythema gyratum repens, palmo-plantar keratoderma, Bazex syndrome, and dermatomyositis, hoping to contribute to the familiarity of dermatologists with the identification and early diagnosis of this group. (Source: Clinics in Dermatology)

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Cutaneous signs of systemic disease

Clinics in Dermatology — Sat, 20 Aug 2011 15:44:23 +0100

Abstract: Commonly used dermatologic eponyms and characteristic skin signs are enormously helpful in guiding a diagnosis, even though they may not be pathonemonic. They include, on the nails, Aldrich-Mees' lines (syn.: Mees' lines), Beau's lines, Muehrcke's lines, Terry's nails, and half and half nails, often associated, respectively, with arsenic poisoning, acute stress or systemic illness, severe hypertension, liver disease and uremia, and, around the nails, Braverman's sign, associated with collagen-vascular disease. Elsewhere, one may see the Asboe-Hansen and Nikolsky's signs, indicative of the pemphigus group of diseases, Auspitz's sign, a classic finding in psoriasis, Borsieri's and Pasita's signs, seen in early scarlet fever, the butterfly rash, indicative of systemic lupus erythema...

Acanthosis nigricans as a local cutaneous side effect of repeated human insulin injections

Diabetes Research and Clinical Practice — Fri, 12 Aug 2011 04:00:00 +0100

We present a diabetic patient with acanthosis nigricans at the insulin injection site on the abdominal wall. Neglecting rotation of sites for insulin injections and local hyperinsulinemia may play a role in the development of acanthosis nigricans. (Source: Diabetes Research and Clinical Practice)

An obese 16-year-old male with acanthosis nigricans, cardiac risk factors.

Pediatric Annals — Sun, 31 Jul 2011 23:00:00 +0100

Authors: Benuck I PMID: 21815603 [PubMed - in process] (Source: Pediatric Annals)

Girls With PCOS Prone to CVD, Diabetes

Clinical Endocrinology News — Sun, 31 Jul 2011 23:00:00 +0100

Major Finding: Seventy-one percent of the females with PCOS had acanthosis nigricans, 75% had a family history of type 2 diabetes, 71% had a family history of cardiovascular disease, and 87% had a BMI greater than 26 kg/m2. (Source: Clinical Endocrinology News)

Prevalence of metabolic changes in children and adolescents: a systematic review

Revista Paulista de Pediatria — Wed, 27 Jul 2011 05:34:08 +0100

CONCLUSIONS: The metabolic syndrome prevalence among children and adolescents with obesity or overweight reported in the literature showed a wide variability. There was heterogeneity, regarding born the variables chosen to define the presence of metabolic syndrome and their respective cut-off points. (Source: Revista Paulista de Pediatria)

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Verruca Vulgaris in a Plaque of Acanthosis NigricansVerruca Vulgaris in a Plaque of Acanthosis Nigricans

Medscape Today Headlines — Fri, 22 Jul 2011 11:04:24 +0100

Were the bumps on the neck of this obese13-year-old somehow connected to the warts on his fingers? Dermatology Online Journal (Source: Medscape Today Headlines)

Risk factors for medication-induced diabetes

The Journal of Pediatrics — Thu, 21 Jul 2011 17:44:48 +0100

There are many potential causes for diabetes mellitus in children and adolescents. Type 2 diabetes usually results from obesity and the related insulin resistance. The risk factors for diabetes that results from the use of certain medications are less clear. In this issue of The Journal, Amed et al evaluated whether risk factors for medication-induced diabetes were similar to those for type 2 diabetes. The authors found that children with medication-induced diabetes were less likely to be obese, have a family history of diabetes, or have acanthosis nigricans when compared with those with type 2 diabetes. These results suggest important differences in the risk factors and perhaps the pathogenesis of these types of diabetes mellitus. Future research is needed to establish the most important ...

Defining hirsutism in Chinese women: a cross-sectional study

Fertility and Sterility — Thu, 14 Jul 2011 23:00:00 +0100

Conclusion(s): An mFG score of 5 or greater indicates hair growth above the norm among women in the general Southern Chinese population, a cut-off value that decreases with increasing age. (Source: Fertility and Sterility)

Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma

Anais Brasileiros de Dermatologia — Sun, 03 Jul 2011 18:03:30 +0100

Apresenta-se o caso clínico de um doente de 57 anos, previamente saudável, sem sintomatologia sistêmica, que, num curto intervalo de tempo, desenvolve múltiplas lesões semelhantes a verrugas virais no tronco, membros e face, lesões típicas de acantose nigricante nas grandes pregas e uma queratodermia difusa palmar com paquidermatoglifia. Os exames complementares de diagnóstico revelaram uma neoplasia gástrica metastizada. Apesar da instituição da terapêutica, com efeito transitório na neoplasia e nas lesões cutâneas, o doente viria a falecer em 14 meses. Salientamos a associação destas três dermatoses paraneoplásicas num mesmo paciente: papilomatose cutânea florida, acantose nigricante maligna e tripe palms que parecem ter um mecanismo patogênico comumThis paper report...

Screening Obese Students for Acanthosis Nigricans and Other Diabetes Risk Factors in the Urban School-Based Health Center

Clinical Pediatrics — Sat, 02 Jul 2011 23:00:00 +0100

Conclusion. AN can be easily identified by trained health care professionals even in busy school-based clinic settings. Checking for AN and appropriate education and counseling should become a routine part of electronic documentation in overweight youth. (Source: Clinical Pediatrics)

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Girls With PCOS Have CVD, Diabetes Risk Factors

Ob.Gyn. News — Thu, 30 Jun 2011 23:00:00 +0100

Major Finding: Seventy-one percent of the females had acanthosis nigricans, 75% had a family history of type 2 diabetes mellitus, 71% had a family history of cardiovascular disease, and 87% had a BMI greater than 26 kg/m2. (Source: Ob.Gyn. News)

Verruca vulgaris in a plaque of acanthosis nigricans.

Dermatol Online J — Mon, 27 Jun 2011 14:15:08 +0100

We present a case of multiple warts within a plaque of acanthosis nigricans probably related to autoinoculation. PMID: 21696689 [PubMed - in process] (Source: Dermatol Online J)

Palifermin: Acanthosis nigricans: case report

Reactions — Sat, 18 Jun 2011 16:44:29 +0100

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Acanthosis Nigricans and Pseudoacanthosis Nigricans

Consultant Live — Wed, 15 Jun 2011 12:00:00 +0100

The dorsal surface of the left hand of a 37-year-old woman with severe Parkinson disease shows finger joint extensor area hyperpigmentation, which is most prominent over the proximal interphalangeal joints. (Source: Consultant Live)

Cutaneous disorders in 500 diabetic patients attending diabetic clinic

Indian Journal of Dermatology — Wed, 04 May 2011 23:00:00 +0100

Conclusion: Well-controlled diabetes decreases the prevalence of DM-specific cutaneous disorders associated with chronic hyperglycemia. It is necessary to have a dermatologist in the diabetic clinic for early detection of potentially grave or predisposing conditions. (Source: Indian Journal of Dermatology)

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Congenital generalized lipodystrophy of Berardinelli-Seip type: A rare case

Indian Journal of Dermatology, Venereology and Leprology — Mon, 18 Apr 2011 23:00:00 +0100

We report a case of this form of lipodystrophy. The patient had several cutaneous manifestations, including severe acanthosis nigricans, generalized hyperpigmentation, curly scalp hair, prominent subcutaneous veins, and enlarged clitoris. She also had associated celiac disease. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Skin Tag and Acanthosis Nigricans: Do they have a Predictive Value for Gestational Diabetes Mellitus?

Experimental and Clinical Endocrinology and Diabetes — Tue, 05 Apr 2011 23:00:00 +0100

Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1270478AbstractBackground: Gestational diabetes mellitus (GDM) is a metabolic condition that can cause severe fetal and maternal morbidity. Early diagnosis and treatment of GDM can significantly prevent maternal and perinatal morbidity.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)

News Beyond Our Pages

Journal of Allergy and Clinical Immunology — Thu, 31 Mar 2011 23:00:00 +0100

Although a large body of evidence is accumulating linking obesity and asthma, no one can say confidently which comes first. Cottrel et al (Am J Respir Crit Care Med 2011;183:441-8) analyzed lipid profiles, asthma diagnosis, and body mass index in more than 17,000 children participating in a cardiac risk detection study to determine whether abnormal metabolic indicators were associated with obesity and asthma. The authors reported that asthma diagnosis is associated significantly with increased levels of triglycerides, regardless of body mass index. Additionally, they found significant association between asthma and altered glucose metabolism using evidence of acanthosis nigricans as a marker of insulin resistance. Cottrel et al offered the theory that early metabolic disturbances from poor...

The co‐occurrence of obesity, elevated blood pressure, and acanthosis nigricans among American Indian school children: Identifying individual heritage and environment‐level correlates

American Journal of Human Biology — Sun, 27 Mar 2011 23:00:00 +0100

Conclusion:PIH appeared to be an important correlate of overweight and obesity, except when adjusted for the co‐occurrence of high blood pressure and AN. Overall, the prevalence and co‐occurrence of various risk factors in this population was high. Obesity prevention initiatives targeting families and communities are needed, as well as access to screening and treatment services. Am. J. Hum. Biol. 2011. © 2011 Wiley‐Liss, Inc. (Source: American Journal of Human Biology)

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Beare-Stevenson Syndrome: Two Dutch Patients With Cerebral Abnormalities

Pediatric Neurology — Tue, 15 Mar 2011 15:57:12 +0100

We report what is to our knowledge the first 2 Dutch patients with this syndrome, both caused by the mutation Tyr375Cys in the fibroblast growth factor receptor 2 gene. The patients exhibited a simplified gyral pattern, an abnormal posterior fossa, and an abnormal hippocampus on cranial magnetic resonance imaging. We discuss the clinical and radiologic findings in fibroblast growth factor receptor 2 gene-related BSS. (Source: Pediatric Neurology)

A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into the Pathogenicity of Nonfarnesylated Prelamin-A.

The Journal of Clinical Endocrinology and Metabolism — Wed, 23 Feb 2011 00:00:00 +0100

Conclusions We reveal that a homozygous mutation of prelamin-A preventing its farnesylation leads to a severe lipodystrophic laminopathy in humans, which can be associated with cardiac conduction disturbances, stressing the pathogenicity of nonfarnesylated prelamin-A in human laminopathies. PMID: 21346069 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

[Atypical presentation of a premature ovarian failure with deletion of X chromosome.]

Gynecologie, Obstetrique et Fertilite — Mon, 31 Jan 2011 00:00:00 +0100

Authors: Harzallah F, Waghlani R, Amouri A In order to illustrate a particular clinical presentation of premature ovarian failure, we report the case of a 16-year-old girl, who presented with primary amenorrhea. Physical examination discovered central obesity and an extent acanthosis nigricans in the neck and in the axillae. Pubertal stage was quoted S3P3 and external genitalia were normal. Oral glucose test revealed glucose intolerance and hormonal investigation discovered hyperinsulinemia and elevated level of FSH. Pelvic echography found infantile internal genitalia and genetic analysis discovered a deletion in the long arm of one of X chromosomes. PMID: 21288754 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)

Prevalence of Acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome

BMC Research Notes — Fri, 28 Jan 2011 00:00:00 +0100

Conclusions: AN was common in our study population, and although it did not have a high enough sensitivity to be utilized as screening test for metabolic syndrome, the presence of AN strongly predicts metabolic syndrome. (Source: BMC Research Notes)

A spectrum of scaly rashes

Archives of Disease in Childhood - Education and Practice — Wed, 12 Jan 2011 00:00:00 +0100

Dermatophile has a new format. From now on, it will take the form of a short quiz to test and inform your knowledge of dermatology relevant to paediatrics. Any suggestions for improvement or topics you would like to be covered are welcome. Please email comments and feedback to p-lio@northwestern.edu. Theme: Scaly rashesSelect the one best answer from the following:a. Tinea corporis (ringworm) b. Acanthosis nigricans c. Confluent and reticulated papillomatosis (CARP) d. Pityriasis (tinea) versicolor e. Drug hypersensitivity eruption f. Scabies infestation g. Terra firma-forme dermatosis Answers to the following quiz questions can be found on page 39. (Source: Archives of Disease in Childhood - Education and Practice)

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Muenke syndrome with pigmentary disorder and probable hemimegalencephaly: An expansion of the phenotype

American Journal of Medical Genetics Part A — Wed, 29 Dec 2010 01:22:09 +0100

We describe a 2‐year‐old boy born to healthy, consanguineous parents. He had craniofacial asymmetry with left frontal bossing, midface hypoplasia, proptosis, and low‐set ears. In addition, he had curly, light hair, and oval hypomelanotic patches in the abdomen, lower limbs and back and one hyperpigmented patch in the groin without acanthosis nigricans. Cranial three‐dimensional CT scan showed right‐coronal, sagittal, and lambdoid suture synostoses. His cranial MRI at 2‐months of age showed left hemimegalencephaly, hypoplasia of corpus callosum, and an abnormal configuration of hippocampus. In spite of these cranial findings, he had mild developmental delay and his neurological examination showed symmetric strength, tone and reflexes. Apart from febrile seizures, there was no hi...

Acne‐associated syndromes: models for better understanding of acne pathogenesis

Journal of the European Academy of Dermatology and Venereology — Wed, 29 Dec 2010 00:00:00 +0100

AbstractAcne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea‐acne‐hirsutism‐androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism‐insulin resistance‐acanthosis nigricans (HAIR‐AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis‐acne‐pustulosis‐hyperostosis‐osteitis (SAPHO) and pyogenic arthritis‐pyoderma g...

Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic

Human Reproduction — Tue, 21 Dec 2010 00:00:00 +0100

CONCLUSIONS Young indigenous South Asians with PCOS have greater odds of being centrally obese, with a third having the MetS that bears no relationship to the androgenic phenotype. Significant predictors for MetS within the PCOS cohort are advancing age, obesity determined by the Asian cut off (BMI >25 kg/m2) and AN, while family history of diabetes, hyperandrogenism and elevated SHBG have no predictive value. (Source: Human Reproduction)

[Difficult to manage diabetes mellitus associated with generalized congenital lipodystrophy. Report of two cases.]

Anales de Pediatria — Thu, 16 Dec 2010 00:00:00 +0100

Authors: Cardona-Hernández R, Suárez-Ortega L, Torres M Generalized congenital lipodystrophy or Berardinelli-Seip Syndrome is a rare autosomal recessive condition characterized by the absence of adipose tissue and eventually a defect in leptin synthesis. Affected subjects tend to show a classical phenotype with acromegaloid appearance, generalized atrophy of subcutaneous adipose tissue with muscular hypertrophy, acanthosis nigricans, hepatomegaly and prominent abdomen. From metabolic point of view and as a consequence of leptin absence, hypertriglyceridemia leading to hepatic steatosis and insulin resistance may appear. Two cases of unrelated subjects affected of generalized congenital lipodystrophy are presented. Both developed difficult-to-manage diabetes mellitus and were treated ...

Cutaneous manifestations of internal malignancies in a tertiary health care hospital of a developing country

Anais Brasileiros de Dermatologia — Sat, 11 Dec 2010 16:02:33 +0100

In a public hospital in Lima, Peru, 24 patients with 16 types of paraneoplastic dermatoses were identified by data collection. The most frequent dermatosis was dermatomyositis (four patients). The other dermatoses were malignant acanthosis nigricans, palmoplantar keratoderma, bullous dermatoses, lymphomatoid papulosis, edematous scarring vasculitic panniculitis, Norwegian scabies, primary systemic amyloidosis, necrolytic migratory erythema, infective dermatitis, pancreatic panniculitis, generalized pruritus, Lesser-Trelat syndrome, and acquired ichthyosis. Most of these paraneoplastic dermatoses were diagnosed before (45.8%) or at the time of (38.5%) the diagnosis of the underlying malignancy. The most frequent underlying malignancies were lymphoma, adenocarcinomas of the upper digestive t...

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Crouzon syndrome with acanthosis nigricans: a case-based update

Child's Nervous System — Mon, 06 Dec 2010 18:44:46 +0100

Discussion Because several organs might be affected the recognition of such syndrome is important for a correct management of the patient as well as a proper information and genetic counseling of the families. Content Type Journal ArticleDOI 10.1007/s00381-010-1347-zAuthors Federico Di Rocco, Unité de Chirurgie Craniofaciale, Neurochirurgie Pédiatrique Hôpital Necker Enfants Malades, Centre de Référence Maladies rares Dysostoses Craniofaciales, 149 rue de Sèvres, 75015 Paris, FranceCorinne Collet, Service de Biochimie et de Biologie Moléculaire, Hôpital Lariboisière, Paris, FranceLaurence Legeai-Mallet, INSERM U781, Hôpital Necker Enfants Malades, Université Paris Descartes, Paris, FranceEric Arnaud, Unité de Chirurgie Craniofaciale, Neurochirurgie Pédia...

Acanthosis Nigricans and Hypochondroplasia in a Child with a K650Q Mutation in FGFR3

Pediatric Dermatology — Wed, 24 Nov 2010 00:00:00 +0100

We report a child who presented with extensive acanthosis nigricans, short stature, and radiographic evidence of hypochondroplasia. Genetic analysis revealed a heterozygous K650Q mutation in FGFR3. (Source: Pediatric Dermatology)

Unilateral nevoid acanthosis nigricans and neurofibromatosis1: An unusual association

Indian Journal of Dermatology, Venereology and Leprology — Fri, 12 Nov 2010 00:00:00 +0100

AS KrishnaramIndian Journal of Dermatology, Venereology, and Leprology 2010 76(6):715-717 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Chronic pruritus: a paraneoplastic sign

Dermatologic Therapy — Mon, 01 Nov 2010 00:00:00 +0100

ABSTRACTChronic itch could be a presenting sign of malignancy. Pruritus of lymphoma is the common prototype of paraneoplastic itch and can precede other clinical signs by weeks and months. Paraneoplastic pruritus has also been associated with solid tumors and is an important clinical symptom in paraneoplastic skin diseases such as erythroderma, Grovers disease, malignant acanthosis nigricans, generalized granuloma annulare, Bazex syndrome, and dermatomyositis. In any case with high index of suspicion a thorough work‐up is required. This review highlights the association between itch and malignancy and presents new findings related to pathophysiological mechanisms and the treatment of itch associated with malignancy. Combinative therapies reducing itch sensitization and transmission using...

Diagnosis and treatment of cutaneous paraneoplastic disorders

Dermatologic Therapy — Mon, 01 Nov 2010 00:00:00 +0100

ABSTRACTThe skin plays a critical role in the detection of internal malignances. Cutaneous signs of these disorders afford clinicians opportunities for early diagnosis and treatment. We aim to succinctly review the recognition, diagnosis, and treatment of selected cutaneous paraneoplastic diseases. Skin disorders that may be associated with paraneoplastic syndromes include: cutaneous metastases, tripe palms, Sweet's syndrome, glucagonoma, Paget's disease and extramammary Paget's disease, acanthosis nigricans, Birt‐Hogg‐Dube syndrome, basal cell nevus syndrome, Bazex syndrome (acrokeratosis paraneoplastica), carcinoid syndrome, Cowden's disease(multiple hamartoma syndrome), dermatomyositis, erythema gyratum repens, ichthyosis aquisita, von Recklinghausen's disease, pityriasis rotunda, p...

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Metabolic Abnormalities Independent of Weight Linked to Childhood Asthma

Medscape Today Headlines — Mon, 04 Oct 2010 13:30:00 +0100

A large analysis finds that metabolic abnormalities, as indicated by elevated triglyceride levels and acanthosis nigricans, may promote the development of childhood asthma. Medscape Medical News (Source: Medscape Today Headlines)

Metabolic Abnormalities in Children with Asthma.

American Journal of Respiratory and Critical Care Medicine — Thu, 16 Sep 2010 23:00:00 +0100

CONCLUSIONS: This study provides the first set of community-based data linking asthma, body mass and metabolic variables in children. In particular, these findings uniquely describe a statistically significant association between asthma and abnormal lipid and glucose metabolism beyond BMI associations. PMID: 20851922 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Normal-Weight 14-Year-Old Girl with Acanthosis Nigricans and Markedly Increased Hepatic Steatosis: Evidence for the Important Role of Ectopic Fat Deposition in the Pathogenesis of Insulin Resistance in Childhood and Adolescence

Karger Publishers — Tue, 14 Sep 2010 23:00:00 +0100

Horm Res Paediatr (DOI:10.1159/000319707) (Source: Karger Publishers)

Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening.

Dermatol Online J — Sat, 11 Sep 2010 19:03:03 +0100

We present the case of an 81-year-old man with a 12-month history of anorexia, weight loss, and clinical evidence of extensive acanthosis nigricans. After exhaustive and repeated investigations a papillary thyroid carcinoma and a follicular adenoma were identified and he improved upon its resection. To our knowledge, P-AN in association with thyroid neoplasm has been reported on only one previous occasion. PMID: 20804685 [PubMed - in process] (Source: Dermatol Online J)

Idiopathic eruptive macular pigmentation or acanthosis nigricans?

Indian Journal of Dermatology, Venereology and Leprology — Mon, 06 Sep 2010 23:00:00 +0100

Rajiv Joshi, Prashant K PalwadeIndian Journal of Dermatology, Venereology, and Leprology 2010 76(5):591-591A 21-year-old male presented with numerous asymptomatic dark brown to brown black pigmented macules and barely raised plaques on the face, trunk and extremities, developing over a period of 2 year. The surface of most lesions had a velvety raised surface similar in appearance to acanthosis nigricans and a biopsy from one of the lesions showed pigmented papillomatosis. This case fulfils all the criteria for idiopathic eruptive macular pigmentation (IEMP) with papillomatosis, and the clinical appearance of acanthosis nigricans in most lesions suggests that IEMP is a form of eruptive acanthosis nigricans. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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Correspondence: Seborrhoeic keratoses and acanthosis nigricans in a long‐term survivor of thanatophoric dysplasia

British Journal of Dermatology — Fri, 20 Aug 2010 05:39:36 +0100

(Source: British Journal of Dermatology)

Acanthosis Nigricans: High Prevalence and Association With Diabetes in a Practice-based Research Network Consortium--A PRImary Care Multi-Ethnic Network (PRIME Net) Study

Medscape Today Headlines — Thu, 05 Aug 2010 10:37:30 +0100

Acanthosis nigricans has been shown in many cases to be associated with hyperinsulinemia. Can it serve as a marker of increased diabetes risk? Journal of the American Board of Family Medicine (Source: Medscape Today Headlines)

Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations

American Journal of Medical Genetics Part A — Mon, 02 Aug 2010 23:00:00 +0100

In conclusion, mutations in PTRF result in a novel phenotype that includes generalized lipodystrophy with mild metabolic derangements, myopathy, cardiac arrhythmias, atlantoaxial instability, and pyloric stenosis. It is unclear how mutations in PTRF, which plays an essential role in formation of caveolae, affect a wide variety of tissues resulting in a variable phenotype. © 2010 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)

Malignant Acanthosis Nigricans Associated with Ovarian Cancer

Karger Publishers — Thu, 01 Jul 2010 23:00:00 +0100

Case Rep Dermatol 2010;2:103â109 (DOI:10.1159/000317116) (Source: Karger Publishers)

Extensive segmental acanthosis nigricans form of epidermal nevus.

Dermatol Online J — Thu, 01 Jul 2010 06:21:03 +0100

We present a case of a 14-year-old male with multiple hyperpigmented, hyperkeratotic plaques on the upper body, axillae, and groin with a segmental distribution following Blaschko lines. Histopathological investigation showed aspects of both acanthosis nigricans and epidermal nevus. So far, screening has not revealed any internal abnormalities. As previous cases show a clear association with internal diseases, repetitive screening for internal diseases and syndromes is suggested in the case of the acanthosis nigricans form of epidermal nevus. Treatment of the condition remains a challenge. PMID: 20579462 [PubMed - in process] (Source: Dermatol Online J)

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Acanthosis Nigricans Among Northern Plains American Indian Children.

The Journal of School Nursing — Wed, 30 Jun 2010 23:00:00 +0100

Authors: Brown B, Noonan C, Bentley B, Conway K, Corcoran M, Fourstar K, Gress S, Wagner S The purpose of this study is to present cross-sectional and prospective data on acanthosis nigricans (AN) prevalence in the context of other risk factors for diabetes including high body mass index (BMI), abnormal blood pressure (BP), physical inactivity and family history of diabetes among Northern Plains American Indian (AI) children. Standardized health measures were collected in 2,520 K-12th-grade AI students for AN, BMI, and BP. Data were also collected on family history of diabetes and physical activity. Approximately, 9.7% of the participants were positive for AN. AN was associated with high BMI, abnormal BP, and diabetes family history. Sports participation was inversely associated with A...

Seborrhoeic keratoses and acanthosis nigricans in a long‐term survivor of thanatophoric dysplasia

British Journal of Dermatology — Wed, 30 Jun 2010 23:00:00 +0100

(Source: British Journal of Dermatology)

Do Self- or Parent-Reported Dietary, Physical Activity, and Sedentary Behaviors Predict Worsening Obesity in Children?

The Journal of Pediatrics — Sun, 13 Jun 2010 23:00:00 +0100

Conclusions: Our findings suggest that the risk factors and self- or parent-reported risk behaviors routinely assessed by pediatric clinicians have limited ability to predict future growth trends, demonstrating the difficulty in determining which patients have the greatest risk of progression of obesity. (Source: The Journal of Pediatrics)

An Autosomal Recessive Syndrome of Joint Contractures, Muscular Atrophy, Microcytic Anemia, and Panniculitis-Associated Lipodystrophy.

The Journal of Clinical Endocrinology and Metabolism — Tue, 08 Jun 2010 23:00:00 +0100

Conclusions: We conclude that these patients represent a novel autoinflammatory syndrome resulting in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy. The molecular genetic basis of this disorder remains to be elucidated. PMID: 20534754 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Long survival in Rabson–Mendenhall syndrome

Diabetes Research and Clinical Practice — Sun, 06 Jun 2010 23:00:00 +0100

The Rabson–Mendenhall syndrome (RMS) is one of the most severe forms of insulin resistance . It is characterized by extreme insulin resistance with hyperinsulinemia, acanthosis nigricans, teeth and nail dysplasia, pineal hyperplasia and growth retardation . (Source: Diabetes Research and Clinical Practice)

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Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance

Journal of Inherited Metabolic Disease — Thu, 03 Jun 2010 07:57:39 +0100

Abstract In Npc1 null mice, a model for Niemann Pick Disease Type C1, it has been reported that hepatocyte insulin receptor function is significantly impaired, consistent with growing evidence that membrane fluidity and microdomain structure have an important role in insulin signal transduction. However, whether insulin receptor function is also compromised in human Niemann Pick disease Type C1 is unclear. We now report a girl who developed progressive dementia, ataxia and opthalmoplegia from 9 years old, followed by severe acanthosis nigricans, hirsutism and acne at 11 years old. She was diagnosed with Niemann Pick Disease type C1 (OMIM#257220) based on positive filipin staining and reduced cholesterol-esterifying activity in dermal fibroblasts, and homozygosity ...

Seborrheic keratoses and acanthosis nigricans in a long-term survivor of thanatophoric dysplasia.

The British Journal of Dermatology — Thu, 27 May 2010 23:00:00 +0100

Authors: Nakai K, Yoneda K, Moriue T, Munehiro A, Fujita N, Moriue J, Yokoi I, Haba R, Itoh S, Kubota Y PMID: 20518778 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Seborrhoeic keratoses and acanthosis nigricans in a long-term survivor of thanatophoric dysplasia

British Journal of Dermatology — Thu, 27 May 2010 23:00:00 +0100

(Source: British Journal of Dermatology)

Association of insulin receptor genetic variants with polycystic ovary syndrome in a population of women from Central Europe

Fertility and Sterility — Wed, 19 May 2010 23:00:00 +0100

To assess the role of the insulin receptor gene in polycystic ovary syndrome (PCOS) we performed a case-control study in a female population (n = 226) from Central Europe by examining the genetic associations of single nucleotide polymorphisms (rs8107575, rs2245648, rs2245649, rs2963, rs2245655, and rs2962) and inferred haplotypes around exon 9 of this gene. The ancestral T allele of single nucleotide polymorphism rs2963 or the corresponding haplotype (GGTC-C) showed association with PCOS with odds ratio 2.99, 95% confidence interval 1.4–6.3, independent of obesity but related to the presence of Acanthosis nigricans and insulin resistance, metabolic syndrome, or hyperandrogeny, thus providing a frame for future fine mapping of the susceptibility loci in PCOS. (Source: Fertility and Steri...

Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies.

The Journal of Clinical Endocrinology and Metabolism — Tue, 18 May 2010 23:00:00 +0100

Conclusions: In seven patients with type B insulin resistance, standardized treatment with rituximab, cyclophosphamide, and pulse steroids results in remission of the disease. Future studies will determine whether this treatment protocol can be applied to other autoantibody/cell surface receptor disease states. PMID: 20484479 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

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Subject index

Journal of the American Academy of Dermatology — Fri, 14 May 2010 13:06:10 +0100

Acanthosis nigricans Acanthosis nigricans in a patient with sarcoma of unknown origin (Brantsch and Moerhle). 2010;62:527-8 (Case letter) (Source: Journal of the American Academy of Dermatology)

Diagnosis and treatment of Acanthosis nigricans.

Skinmed — Sat, 01 May 2010 00:00:00 +0100

Authors: Kapoor S Acanthosis nigricans is a dermatologic condition commonly seen in diabetics and obese individuals. Histologically, it is characterized by the proliferation of epidermal keratinocytes and fibroblasts. Clinically, the lesions appear as dark-brown thickened plaques. The neck and the axillas are the most commonly affected sites. Treatment involves management of the underlying disorder. Topical tretinoin and calcipotriol have also been used with some limited success. Other treatment options include laser and surgical excision. PMID: 21137622 [PubMed - in process] (Source: Skinmed)

Cardiometabolic abnormalities in patients with berardinelli-Seip syndrome

Arquivos Brasileiros de Cardiologia — Fri, 16 Apr 2010 12:56:54 +0100

CONCLUSION: A high prevalence of cardiovascular and metabolic abnormalities was observed in young asymptomatic individuals with BSS. These findings point to the need for systematic cardiological follow-up and of preventive measures in this high-risk group.FUNDAMENTO: El síndrome de Berardinelli-Seip (SBS) o lipodistrofia generalizada congénita, afecta frecuentemente el aparato cardiovascular y también promueve anormalidades metabólicas que involucran los metabolismos glucídico y lipídico. OBJETIVO: Evaluar la prevalencia de las anormalidades cardiovasculares y metabólicas en portadores de SBS. MÉTODOS: Veintidós pacientes del Estado de Rio Grande do Norte (Brasil), con diagnóstico de SBS, se sometieron a evaluación clínica, electrocardiograma de reposo, ecocardiograma doppler, ...

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome.

European Journal of Endocrinology — Mon, 05 Apr 2010 23:00:00 +0100

Conclusions: Hyperandrogenemic PCOS phenotypes have greatest degree of insulin resistance and inflammation. The use of nsulin resistance and inflammatory markers may help identify adolescent girls with PCOS at risk of cardiometabolic syndrome. PMID: 20371657 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)

Cutaneous Manifestations of Internal Malignancy

Current Problems in Surgery — Mon, 05 Apr 2010 14:34:24 +0100

Acanthosis nigricans can be categorized as benign or malignant. The benign versions of acanthosis nigricans are relatively common; the malignant version is rare, with only approximately 1000 reported cases in the world literature (). It occurs in men and woman equally and has no racial predilection or known familial association. Malignant acanthosis nigricans (MAN) primarily affects adults over the age of 40 years and has a sudden onset and extensive cutaneous involvement. In contrast, the benign versions usually manifest earlier in life and have a more insidious onset. (Source: Current Problems in Surgery)

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The Obese Child With Acanthosis Nigricans

Pediatric News — Wed, 31 Mar 2010 23:00:00 +0100

DR. CARDER is a pediatric dermatologist in private practice in Dallas and a clinical assistant professor of dermatology at the University of Texas Southwestern Medical School, also in Dallas. She reported having no relevant financial conflicts of interest. E-mail her at pdnews@elsevier.com. (Source: Pediatric News)

Acanthosis Nigricans: Cutaneous Marker of Metabolic Abnormalities

AAP Grand Rounds — Wed, 31 Mar 2010 19:04:35 +0100

(Source: AAP Grand Rounds)

Noninvasive Screening for Risk Factors of Type 2 Diabetes in Young, Rural, Caucasian Children.

The Journal of School Nursing — Wed, 24 Mar 2010 00:00:00 +0100

Authors: Peterson S, Sheffer S, Roth SL, Bennett PA, Lloyd L School nurses play an important role in identifying students who are at risk for Type 2 diabetes mellitus (T2DM). Few studies have screened Caucasian students, and none have targeted rural, low-income, elementary children. The five noninvasive risk factors used for this study were family history, high body mass index (BMI) for age/sex, racial/ethnic background, hypertension, and acanthosis nigricans. Two thirds of those screened (n = 299) had at least one of the five risk factors for T2DM. Seventeen students (5.6% of those screened) had three or more of the five risk factors and were considered at risk for T2DM. Fifteen percent (n = 43) had hypertension or prehypertension, and 18% (n = 53) were morbidly obese. Hypertension an...

A Comparison of Blood Pressure, Body Mass Index, and Acanthosis Nigricans in School-Age Children.

The Journal of School Nursing — Wed, 24 Mar 2010 00:00:00 +0100

Authors: Otto DE, Wang X, Tijerina SL, Reyna ME, Farooqi MI, Shelton ML The purpose of this retrospective quantitative study was to examine the relationships among acanthosis nigricans (AN), body mass index (BMI), blood pressure (BP), school grade, and gender in children attending elementary school located in South West Texas. Data were collected by attending school district nurses. Researchers reviewed 7,026 previously collected records from a state mandated public school health screening program in elementary school Grades 3, 5, 7, and 9, conducted by school nurses. Of 7,026 records, 6,867 were included for the secondary analysis. A logistic regression analysis was carried out with the AN marker as the dependant variable and school grade, gender, BMI, and BP as the independent variab...

Acanthosis nigricans: Treating underlying disorders may improve skin condition

MayoClinic.com Full Feed — Sun, 21 Mar 2010 01:45:00 +0100

Acanthosis nigricans — Comprehensive overview covers causes, treatment of this skin condition. (Source: MayoClinic.com Full Feed)

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Treatment with Recombinant Human Insulin-Like Growth Factor (rhIGF)-I/rhIGF Binding Protein-3 Complex Improves Metabolic Control in Subjects with Severe Insulin Resistance.

The Journal of Clinical Endocrinology and Metabolism — Tue, 16 Mar 2010 00:00:00 +0100

Conclusions: rhIGF-I/rhIGFBP-3 is well tolerated and clinically effective in subjects with SIR. PMID: 20233784 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

A study of androgen and estrogen receptors α, β in skin tags

Indian Journal of Dermatology — Fri, 05 Mar 2010 14:02:58 +0100

Conclusion: </b> These results suggest the possible role of androgen and estrogen receptors in etiogenesis of skin tags, and propose that the neck is an androgen dependent area just similar to the axillae and the groins, though hairless. (Source: Indian Journal of Dermatology)

Acanthosis Nigricans in Children With Type 2 Diabetes

Medscape Today Headlines — Tue, 16 Feb 2010 15:22:29 +0100

Can this skin finding serve as a marker for type 2 DM in children? Medscape Pediatrics (Source: Medscape Today Headlines)

Acanthosis nigricans in a patient with sarcoma of unknown origin

Journal of the American Academy of Dermatology — Tue, 16 Feb 2010 14:09:36 +0100

To the Editor: A 66-year-old man presented with a 2-month history of a slowly enlarging right axillary lymph node. Four years earlier, symmetric papillomatosis and darkening of the axillae and neck had developed (). The patient did not have diabetes and had a history of melanoma excised from his back 17 years earlier. The node was resected (); a skin biopsy specimen showed acanthosis nigricans, with acanthosis, papillomatosis, hyperkeratosis, and increased dermal pigmentation (). Histologic () and immunohistochemical analyses of the axillary node were consistent only with an unspecified sarcoma. Melanoma was excluded by immunohistochemistry. Computed tomography scans revealed metastases in multiple lymph nodes, the liver, and the spleen; the primary tumor was not found. (Source: Journal of...

Acanthosis Nigricans

Consultant Live — Thu, 04 Feb 2010 12:00:00 +0100

A 5-ft 1-in, 183-lb 14-year-old girl was concerned about the areas of thickened hyperpigmentation on her posterior neck and in her cleavage. (Source: Consultant Live)

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A rare association of acanthosis nigricans with Crouzon syndrome

Indian Journal of Dermatology, Venereology and Leprology — Wed, 06 Jan 2010 14:01:46 +0100

Gupta Ajay Kumar, Koley Sankha, Choudhary Sanjiv, Bhake Arvind, Saoji Vikrant, Salodkar AtulIndian Journal of Dermatology, Venereology, and Leprology 2010 76(1):65-67 (Source: Indian Journal of Dermatology, Venereology and Leprology)

This is linear verrucous epidermal nevus, not acanthosis nigricans

Journal of Plastic, Reconstructive & Aesthetic Surgery — Mon, 28 Dec 2009 00:00:00 +0100

This is with reference to an article published in your journal, ‘Acanthosis nigricans and an alternative for its surgical therapy’, Isken T, Sen C, Iscen D, et-al, J Plast Reconstr Aesthet Surg 2009; 62: 148–150. This is to state that the clinical description and image shown in this case report is clearly that of linear verrucous epidermal nevus and not that of acanthosis nigricans. (Source: Journal of Plastic, Reconstructive & Aesthetic Surgery)

Acanthosis Nigricans and Oral Glucose Tolerance in Obese Children

Clinical Pediatrics — Thu, 24 Dec 2009 05:44:22 +0100

(Source: Clinical Pediatrics)

Racial and Ethnic Differences in an Estimated Measure of Insulin Resistance Among Individuals with Type 1 Diabetes.

Diabetes Care — Thu, 10 Dec 2009 00:00:00 +0100

Conclusions: Minorities with type 1 diabetes are significantly more IR, as measured by eGDR, than NHW. Exploring potential mechanisms, including disparities in care and/or physiological variation, may contribute to preventing racial/ethnic differences in IR-associated outcomes. PMID: 20007942 [PubMed - as supplied by publisher] (Source: Diabetes Care)

Mediastinal lymph node metastasis of lung cancer with an unknown primary lesion having concurrent endocrine abnormality and acanthosis nigricans: report of a case.

Annals of Thoracic and Cardiovascular Surgery — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Yoshino N, Yamagishi S, Kubokura H, Mikami I, Hirata T, Koizumi K, Okano T, Futagami A, Kawamoto M, Shimizu K We herein describe a patient we encountered in whom mediastinal lymph node metastasis of lung cancer with an unknown primary lesion was complicated by both an endocrine abnormality and acanthosis nigricans. A 66-year-old male visited a local hospital and was diagnosed as having acanthosis nigricans. The patient was referred to our hospital for further examination. Computed tomography scans of the chest and the abdomen showed no adverse findings except for an enlargement of the mediastinal lymph node. No malignant lesions were detected in examinations of the upper gastrointestinal tract. Based on the above findings, the lesion was thus considered to possibly be mediasti...

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Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome

International Journal of Gynaecology and Obstetrics — Thu, 26 Nov 2009 00:00:00 +0100

Conclusions: Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS. (Source: International Journal of Gynaecology and Obstetrics)

The clinical and metabolic features of Irish patients with acanthosis nigricans

Irish Journal of Medical Science — Tue, 17 Nov 2009 23:44:12 +0100

Conclusion Acanthosis nigricans in Irish subjects is associated with severe obesity and insulin resistance. The analysis highlights that subjects with acanthosis nigricans should be screened for insulin resistance and its complications. Content Type Journal ArticleCategory Poster PresentationsDOI 10.1007/BF03170260Authors S. McQuaid, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandY. Rahman, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandO. Yousif, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandD. O’Gorman, St James’s Hospital Metabolic Research Unit, Department of Endocrinology Dublin IrelandD. Gasparro, St James’s Hospital Metabolic Research ...

Insulin Resistance Linked to Acanthosis Nigricans

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

SAN FRANCISCO — Insulin resistance may be present in patients with acanthosis nigricans, particularly if they are overweight or obese, and research increasingly supports a link between these conditions. (Source: Skin and Allergy News)

[Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population.]

Anales de Pediatria — Mon, 19 Oct 2009 23:00:00 +0100

CONCLUSIONS: Obesity and RI are risk factors for liver steatosis in children and adolescents. Decreased serum adiponectin is closely and independently associated with steatosis. PMID: 19850541 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

Young people with acanthosis nigricans are at high risk for Type 2 diabetes

MedWire News - Diabetes — Mon, 19 Oct 2009 13:09:47 +0100

Study results show that young people with acanthosis nigricans are at increased risk for abnormal glucose metabolism, high blood pressure, and low high-density lipoprotein cholesterol. (Source: MedWire News - Diabetes)

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Hypodontia in Beare-Stevenson Syndrome: An Example of Dental Anomalies in FGFR-related Craniosynostosis Syndromes.

The Cleft Palate-Craniofacial Journal — Mon, 19 Oct 2009 00:00:00 +0100

We report a new case of Beare-Stevenson syndrome characterized by cutis gyrata, craniosynostosis, acanthosis nigricans, ear defects, a prominent umbilical stump and midface hypoplasia. He had dental findings of natal teeth and hypodontia of the primary and permanent teeth. This is the second patient with BSS syndrome to be reported with hypodontia and natal teeth; the first patient was described by Beare in 1969. We review the current literature to investigate the relation between dental anomalies and FGFR-related mutations in Beare-Stevenson syndrome and other craniosynostosis syndromes such as Apert, Crouzon and Pfeiffer. Keywords: Beare-Stevenson syndrome; cutis gyrata; craniosynostosis; dental anomalies, natal teeth; hypodontia; fibroblast growth factor receptor. PMID: 19860525 [Pu...

Acanthosis nigricans identifies young people at high metabolic risk

MedWire News - Dermatology — Fri, 09 Oct 2009 00:00:00 +0100

Presence of acanthosis nigricans identifies a population of young people at high-risk for abnormal glucose homeostasis, high blood pressure, and low high-density lipoprotein cholesterol, report researchers. (Source: MedWire News - Dermatology)

Acanthosis Nigricans Identifies Youth at High Risk for Metabolic Abnormalities

The Journal of Pediatrics — Mon, 05 Oct 2009 00:00:00 +0100

Conclusions: Youth in the AN+ group had severe insulin resistance, and more than 1 in 4 already had abnormal glucose homeostasis. AN identified a high-risk population, for whom appropriate interventions have the potential to attenuate or even prevent the development of diabetes and further metabolic abnormalities. (Source: The Journal of Pediatrics)

Prevalence of acanthosis nigricans and its correlates in a cross-section of Nigerians with type 2 diabetes mellitus.

Tropical Doctor — Sun, 20 Sep 2009 08:46:31 +0100

This report bridges the information gap and documents the prevalence of AN in Nigerians with type 2 DM as well as its clinical correlates. Three hundred and forty consecutive subjects with type 2 DM were examined for the presence of AN and its associated clinical features. The prevalence of AN in type 2 DM in this report is 17%. Factors associated with AN include obesity, a family history of DM, female gender, the presence of hypertension and poor glycaemic control. PMID: 19762579 [PubMed - in process] (Source: Tropical Doctor)

[Skin manifestations, treatment and rehabilitation in overweight and obesity.]

Orvosi Hetilap — Fri, 04 Sep 2009 11:26:19 +0100

Authors: Wenczl E Overweight and obesity is a public health problem in Hungary and in the Western world. It is important to underline that obesity is an illness and an important risk factor for several skin and other diseases. An overview of skin diseases caused or aggravated by obesity (acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, stria, adiposis dolorosa, lymphoedema, chronic venous insufficiency, plantar hyperkeratosis, lipoedema, skin infections, acne inversa, psoriasis, tophi) helps us to look and see as well. Look for the possibility of skin infections as it helps the early diagnosis and to avoid complications. Draw patients' attention to the preventive importance of skin care. In case of an obese patient the usual dosage of most local and systemic dru...

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Malignant acanthosis nigricans with enhanced expression of fibroblast growth factor receptor 3.

Acta Derm Venereol A... — Thu, 20 Aug 2009 13:32:03 +0100

Authors: Hida Y, Kubo Y, Nishio Y, Murakami S, Fukumoto D, Sayama K, Hashimoto K, Arase S PMID: 19688170 [PubMed - in process] (Source: Acta Derm Venereol A...)

Lipodystrophy: an unusual diagnosis in a case of oligomenorrhea and hirsutism.

Obstetrics and Gynecology — Fri, 24 Jul 2009 05:46:30 +0100

CONCLUSION:: Familial partial lipodystrophy, Dunnigan variety, can present with features similar to polycystic ovary syndrome. Diagnosis is critical because the metabolic complications of the disorder have significant morbidity. PMID: 19622949 [PubMed - in process] (Source: Obstetrics and Gynecology)

Juvenile generalized acanthosis nigricans without any systemic disease

Pediatrics International — Wed, 22 Jul 2009 23:00:00 +0100

(Source: Pediatrics International)

Acanthosis Nigricans and Insulin Sensitivity in patients with Achondroplasia and Hypochodroplasia due to FGFR3 mutations.

The Journal of Clinical Endocrinology and Metabolism — Mon, 20 Jul 2009 23:00:00 +0100

Conclusion: Our findings suggest that the development of AN in patients with ACH/HCH is not due to insulin insensitivity either on its own or secondary to treatment with rhGH. Whether the acanthosis nigricans is due to altered melanocyte function in these individuals remains to be established. PMID: 19622626 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Type B insulin resistance in a systemic lupus erythematosus patient

APLAR Journal of Rheumatology — Wed, 15 Jul 2009 23:00:00 +0100

This report describes a case wherein the patient had presented with uncontrolled diabetes and required > 3000 units of human insulin to control hyperglycemia. She also had features of SLE. There was complete recovery following treatment with steroids. (Source: APLAR Journal of Rheumatology)

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Malignant acanthosis nigricans with esophageal cancer

Esophagus — Wed, 17 Jun 2009 09:43:02 +0100

Abstract A 62-year-old woman was referred to our hospital with presenting pigmentation and/or dermal thickening in the nucha, face, axilla, abdomen, and hands. She also presented a history of weight loss of 4 kg during the previous 3 months. She was pathologically diagnosed as having acanthosis nigricans by skin biopsy. She subsequently underwent 18F-FDG-PET, CT, and upper gastrointestinal endoscopy, and then was diagnosed as having malignant acanthosis nigricans with squamous cell carcinoma in the esophagus at the clinical stage of T3, N0, M0, stage IIA in the UICC stage classification. She underwent subtotal esophagectomy through a left thoracotomy with thoracoabdominal two-field lymphadenectomy and esophageal reconstruction using a gastric tube through a retrosternal rou...

[Genetics] A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia

Proceedings of the National Academy of Sciences — Tue, 09 Jun 2009 04:00:00 +0100

Tre-2, BUB2, CDC16, 1 domain family member 4 (TBC1D4) (AS160) is a Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter... (Source: Proceedings of the National Academy of Sciences)

[Miscellanea] Acanthosis nigricans

Archives of Disease in Childhood — Thu, 21 May 2009 04:00:00 +0100

(Source: Archives of Disease in Childhood)

Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population

Journal of Gastroenterology and Hepatology — Wed, 20 May 2009 04:00:00 +0100

Conclusion: The prevalence of NAFLD among adults in this urban Sri Lankan community is high and is strongly associated with constituent features of the metabolic syndrome. (Source: Journal of Gastroenterology and Hepatology)

Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: A new syndrome?

European Journal of Medical Genetics — Sun, 03 May 2009 23:00:00 +0100

We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family. PMID: 19401242 [PubMed - as supplied by publisher] (Source: European Journal of Medical Genetics)

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Re: “Acanthosis nigricans and an alternative for its surgical therapy”

Journal of Plastic, Reconstructive & Aesthetic Surgery — Fri, 24 Apr 2009 09:23:35 +0100

I read with interest the article by Isket et al. describing an alternative surgical therapy for acanthosis nigricans. The authors nicely summarize the multiple variants of acanthosis nigricans, but do not specify which variant their patient had. Their patient's results after surgery appear very good. However, in my judgment, the patient's lesion appeared more consistent with an epidermal nevus rather than acanthosis nigricans. Although the authors note that their patient had received prior therapies (cryotherapy and electrosurgery) and these therapies may have altered the appearance of her condition, her lesions are not typical of acanthosis nigricans which tends to have confluent velvety hyperpigmented plaques. Instead, the figure in their article demonstrates patchy involvement with ski...

A Newborn with Acanthosis Nigricans: Can It Be Crouzon Syndrome with Acanthosis Nigricans?

Pediatric Dermatology — Fri, 17 Apr 2009 04:00:00 +0100

We present a 10-hour-old newborn who presented with bilateral choanal atresia, craniosynostosis and acanthosis nigricans. Molecular tests identified the FGFR3 Ala391Glu substitution confirming the diagnosis of CAN. Of the 35 cases of CAN reported in literature till date, only one child had acanthosis nigricans at birth. This is the first case from India to have been reported with this mutation. (Source: Pediatric Dermatology)

Gastric diffuse large B-cell lymphoma (DLBCL) exhibiting oral acanthosis nigricans and tripe palms

Digestive and Liver Disease — Sun, 05 Apr 2009 23:00:00 +0100

Approximately one-third of non-Hodgkin lymphomas arise primarily from sites other than lymph nodes, such as spleen or bone marrow, and even from sites which normally contain no native lymphoid tissue. The extranodal lymphomas represent a challenge in routine lymphoma diagnosis, due to the variety of histological types, molecular abnormalities and clinical pictures . Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoma encountered in the gastrointestinal tract. This is mainly a disease of older adults in the seventh decade, even though it may occasionally affect children and young adults. It typically produces large, destructive lesions that may invade adjacent structures . (Source: Digestive and Liver Disease)

Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder

Annals of Diagnostic Pathology — Wed, 01 Apr 2009 04:00:00 +0100

We report on what appears to be the first case of a patient, a 48-year-old woman, with anti-Hu paraneoplastic sensory neuropathy and small cell carcinoma of the gallbladder. The patient's neurologic symptoms preceded the diagnosis of small cell carcinoma by 11 months. These symptoms improved after surgical removal of the tumor and chemotherapy. The small cell carcinoma was relatively small and was not associated with gallstones. In spite of the small size of the tumor, it metastasized to a celiac lymph node and probably to the liver. Anti-Hu paraneoplastic sensory neuropathy should be added to the list of paraneoplastic syndromes associated with small cell carcinoma of the gallbladder. (Source: Annals of Diagnostic Pathology)

High prevalence of polycystic ovary syndrome in women with mild hirsutism and no other significant clinical symptoms

Fertility and Sterility — Tue, 31 Mar 2009 23:00:00 +0100

Conclusion(s): Because of the high prevalence of PCOS and the possibility of finding nonclassic 21-hydroxylase deficiency, patients with mild hirsutism need a diagnostic evaluation that should include 17-hydroxyprogesterone measurement plus assessment of ovulation and ovarian ultrasound. (Source: Fertility and Sterility)

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Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder.

Annals of Diagnostic Pathology — Thu, 26 Mar 2009 16:41:29 +0100

Seborrhoeic keratoses in patients with internal malignancies: a case–control study with prospective accrual of patients

Journal of the European Academy of Dermatology and Venereology — Fri, 06 Mar 2009 05:00:00 +0100

Conclusion No association was found between seborrhoeic keratoses and cancer. Furthermore, our data did not provide support to the validity of the Leser-Trélat sign in patients with internal malignancies. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: A case report.

Diabetes Metab — Wed, 25 Feb 2009 05:00:00 +0100

Authors: Collet-Gaudillat C, Billon-Bancel A, Beressi JP A 54-year-old woman was referred to hospital because of poor metabolic control. Clinical examination revealed marked acanthosis nigricans, and a striking lack of adipose tissue on the limbs, and excess fat deposits on the neck and face. She had been treated for diabetes since 2001 with high doses of insulin along with metformin. Clinical tests showed hypertriglyceridaemia with low high density lipoprotein (HDL) cholesterol, and cholestasis with mild cytolysis. Dunnigan syndrome (familial partial lipodystrophy type 2) was suspected and confirmed by molecular genetics. Pioglitazone was added to her treatment, and follow-up showed improvement of metabolic control 7 months after introducing pioglitazone, and improvement of insulin se...

Novel mutations of the BSCL2 and AGPAT2 genes in ten families with Berardinelli-Seip congenital generalized lipodystrophy syndrome.

Clinical Endocrinology — Wed, 18 Feb 2009 05:00:00 +0100

Conclusions: We demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli-Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome). PMID: 19226263 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)

Bilateral Leser-Trelat Sign Mirroring Lung Adenocarcinoma with Early Metastases to the Contralateral Lung.

Southern Medical Journal — Thu, 05 Feb 2009 08:08:38 +0100

We present a unique case of bilateral Leser-Trélat sign on the upper torso which mirrored a lung adenocarcinoma of the upper lobes.Page: 216DOI: 10.1097/SMJ.0b013e31818f604dAuthors: Dasanu, Constantin A. MD, PhD; Alexandrescu, Doru T. MD (Source: Southern Medical Journal)

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Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project.

World Journal of Pediatrics : WJP — Wed, 28 Jan 2009 16:09:10 +0100

CONCLUSIONS: Results are discussed in terms of systematically defining metabolic syndrome for high-risk children, as well as public health and clinical interventions targeting children who are overweight or obese. The presence of AN and morbid obesity might be easily observed markers for metabolic syndrome. PMID: 19172328 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)

New Survey Results Show Huge Burden of Diabetes

Diabetes News from dLife.com — Mon, 26 Jan 2009 05:00:00 +0100

January 26, 2009 (NIH) - In the United States, nearly 13 percent of adults age 20 and older have diabetes, but 40 percent of them have not been diagnosed, according to epidemiologists from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), whose study includes newly available data from an Oral Glucose Tolerance Test (OGTT). Diabetes is especially common in the elderly: nearly one-third of those age 65 and older have the disease. An additional 30 percent of adults have pre-diabetes, a condition marked by elevated blood sugar that is not yet in the diabetic range. The researchers report these findings in the February 2009 issue of Diabetes Care, which posted a pre-print version of the article online at http://diabetes.org/diabetescare. The s...

Berardinelli-Seip syndrome in a 6-year-old boy

Indian Journal of Dermatology, Venereology and Leprology — Fri, 16 Jan 2009 04:12:33 +0100

Babu Priya, Sharma Rakesh, Jayaseelan Elizabeth, Appachu DivyaIndian Journal of Dermatology, Venereology and Leprology 2008 74(6):644-646A 6-year-old boy presented with abnormal habitus since birth, delayed language development, history of frequent falls since 9 months, and fever since 1 week. He was found to have hyperandrogenic features, generalized paucity of fat, generalized muscular overdevelopment, and brownish pigmentation over the flexural creases. Skin biopsy demonstrated features suggestive of acanthosis nigricans with an absence of subcutaneous tissue. After further investigation, a diagnosis of Berardinelli-Seip syndrome with bilateral pneumonia and generalized tonic clonic seizures was made. Clinical features, histopathology, differential diagnosis, and prognosis of this rare ...

Serum and intracellular magnesium deficiency in patients with metabolic syndrome-Evidences for its relation to insulin resistance.

Diabetes Research and Clinical Practice — Sat, 03 Jan 2009 05:00:00 +0100

In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistance. PMID: 19124169 [PubMed - as supplied by publisher] (Source: Diabetes Research and Clinical Practice)

Parental diabetes, pubertal stage, and extreme obesity are the main risk factors for prediabetes in children and adolescents: a simple risk score to identify children at risk for prediabetes

Pediatric Diabetes — Thu, 18 Dec 2008 05:00:00 +0100

Conclusions: The main risk factors for prediabetes were parental diabetes, pubertal stage, and extreme obesity. Screening for prediabetes seems meaningful in subjects with either a parental history of diabetes or a combination of extreme obesity and pubertal stage and detected nearly 90% of the overweight children and adolescents with prediabetes. (Source: Pediatric Diabetes)

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Prevalence of obesity and metabolic syndrome in Indigenous Australian youths

Obesity Reviews — Tue, 16 Dec 2008 05:00:00 +0100

We conducted a cross-sectional study of Indigenous youths residing in the Torres Strait region of Australia to assess the prevalence of obesity and the metabolic syndrome. Data on body mass index (BMI), waist circumference, blood pressure, presence of acanthosis nigricans and blood glucose were collected. Fasting glucose, insulin, C-Peptide, HbA1c and lipids were measured, and an oral glucose tolerance test was performed in those with a BMI greater than 25 (childhood-equivalent cut-points) or fasting glucometer reading >5.5 mmol/L. Of 158 youths, 31% were overweight and 15% were obese, 38% had enlarged waist circumference consistent with central obesity, 43% had acanthosis nigricans and 27% were hypertensive. More females than males had enlarged waist circumferences (59% vs. 13%, P < 0.001...

NOTABLE NOTES: Type 2 Segmental Acanthosis Nigricans: A Historical Case Explained by a New Concept

Archives of Dermatology — Mon, 15 Dec 2008 05:00:00 +0100

(Source: Archives of Dermatology)

Acanthosis nigricans: A practical approach to evaluation and management.

Dermatol Online J — Thu, 11 Dec 2008 05:11:09 +0100

Authors: Higgins SP, Freemark M, Prose NS Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management. PMID: 19061584 [PubMed - in process] (Source: Dermatol Online J)

Clearance of acanthosis nigricans associated with insulinoma following surgical resection

QJM — Mon, 20 Oct 2008 04:00:00 +0100

We report a case wherein the acanthosis disappeared following surgical resection of insulinoma and this strengthens the hypothesis that hyperinsulinaemia is responsible for acanthosis. (Source: QJM)

What every physician should know about polycystic ovary syndrome

Dermatologic Therapy — Mon, 06 Oct 2008 04:00:00 +0100

ABSTRACT: Polycystic ovary syndrome (PCOS) is the most common endocrine cause of hirsutism, acne, and pattern alopecia. It is a heterogeneous syndrome of hyperandrogenic anovulation that is typically due to intrinsic ovarian dysfunction, which is often aggravated by insulin-resistant hyperinsulinemia with its risks of diabetes mellitus and metabolic syndrome and their complications. Because there are many pitfalls to androgen assays, evaluation for hyperandrogenemia is suggested in women with moderate or severe hirsutism or hirsutism equivalents, menstrual irregularity, acanthosis nigricans, or intractable obesity. An endocrinologic work-up is necessary to rule out other hyperandrogenic disorders that require specific therapy (e.g., virilizing tumors, nonclassic congenital adrenal hyperpla...

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The clinical evaluation of hirsutism

Dermatologic Therapy — Mon, 06 Oct 2008 04:00:00 +0100

ABSTRACT: Hirsutism is a disorder of excess growth of terminal hairs in androgen-dependent areas in women. Other cutaneous conditions associated with androgen excess are androgenetic alopecia, acanthosis nigricans, and acne. Hirsutism is often associated with measurably elevated androgen levels, but not in all cases. Androgens in women arise from the ovary and adrenal glands, and peripherally from skin and fat. The most common cause of hirsutism is polycystic ovarian syndrome. Patients with "idiopathic" hirsutism have normal ovulatory cycles and androgen levels. Other causes are late onset congenital adrenal hyperplasia, Cushing's syndrome, and the HAIR-AN syndrome. Pituitary, ovarian, and adrenal tumors are important, but rare causes of hirsutism. A thorough history and examination are im...

Hirsutism: Clinico-investigative profile of 50 Indian patients

Indian Journal of Dermatology — Thu, 02 Oct 2008 12:01:14 +0100

Conclusion:</b> Hirsutism in Indian patients is not uncommon. Adolescent patients appear to be more concerned about hirsutism as compared to those in the older age group who were more often worried of late onset acne. All patients, however, were more concerned for facial hair than those on other body areas signifying that facial hair need to be given higher than current value in F-G score. (Source: Indian Journal of Dermatology)

Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?

European Journal of Endocrinology — Mon, 01 Sep 2008 04:00:00 +0100

CONCLUSION: This is the first report of a large pedigree with the clinical phenotype of HCH plus AN due to a FGFR3 mutation, p.Lys650Thr. This finding demonstrates the coexistence of both conditions due to the same mutation and it might represent a true complex, which should be further established by searching for AN in mild HCH patients or for HCH in patients with AN. PMID: 18583390 [PubMed - in process] (Source: European Journal of Endocrinology)

Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity

BMC Pediatrics - Latest articles — Tue, 12 Aug 2008 04:00:00 +0100

Conclusions: Metabolic syndrome has a prevalence of 36% in children and adolescent population in the study. Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence. (Source: BMC Pediatrics - Latest articles)

Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability

American Journal of Medical Genetics Part A — Tue, 12 Aug 2008 04:00:00 +0100

We report two siblings of Hispanic origin who displayed characteristic features of CGL such as generalized loss of subcutaneous fat from birth, acanthosis nigricans, acromegaloid habitus, umbilical prominence, hepatosplenomegaly, hypoleptinemia, dyslipidemia, and insulin resistance. However, no disease causing variants were detected in the DNA sequence of AGPAT2, BSCL2 or CAV1 genes. Further, whole body magnetic resonance imaging (MRI) in the two siblings revealed marked loss of subcutaneous, intraabdominal and intrathoracic fat like in other patients with CGL, but preservation of bone marrow fat which is invariably lost in all patients with CGL1 and CGL2, but not in the patient reported with CGL3. They also had generalized muscle weakness during infancy and early childhood associated with...

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Prevalence of acanthosis nigricans in relation to anthropometric measures: Community-based cross-sectional study in Korean pre-adolescent school children

Pediatrics International — Sat, 28 Jun 2008 04:00:00 +0100

Conclusions: AN has a good correlation with level of adiposity, and was already present in overweight children that were not considered obese by definition. (Source: Pediatrics International)

Abnormal venous drainage in syndromic craniosynostosis and the role of CT venography

Child's Nervous System — Wed, 25 Jun 2008 09:27:05 +0100

Conclusions Patients with syndromic craniosynostosis often demonstrate abnormal venous anatomy, which can have serious consequences on craniofacial surgery, especially when a posterior decompression is being considered. Based on these findings, the authors assert that those children with some syndromic craniosynostosis being considered for surgery should undergo venographic studies as part of their pre-operative evaluation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00381-008-0667-8Authors Dhruve Satish Jeevan, John Radcliffe Hospital Department of Paediatric Neurosurgery West Wing Level 3, Headley Way Oxford OX3 9DU UKPhillip Anlsow, John Radcliffe Hospital Department of Neuroradiology Oxford UKJayaratnam Jayamohan, John Radcliffe Hospital Depar...

Nevoid acanthosis nigricans

Indian Journal of Dermatology, Venereology and Leprology — Sat, 21 Jun 2008 20:11:14 +0100

Das Jayanta Kumar, Sengupta Sujata, Gangopadhyay AsokIndian Journal of Dermatology, Venereology and Leprology 2008 74(3):279-280 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Prevalence of acanthosis nigricans in relation to anthropometric measures: Community-based cross-sectional study in Korean pre-adolescent school children

Pediatrics International — Thu, 19 Jun 2008 12:12:12 +0100

Pediatrics International, Volume 0, Issue 0, Page ???, OnlineEarly Articles. AbstractBackground: This cross-sectional study was performed to assess the prevalence of acanthosis nigricans (AN) across various anthropometric measures and to identify the cut-offs for anthropometric indices of adiposity for development of AN in Asian ... (Source: Pediatrics International)

Nevoid acanthosis nigricans

Indian Journal of Dermatology, Venereology and Leprology — Tue, 17 Jun 2008 22:18:14 +0100

Das Jayanta Kumar, Sengupta Sujata, Gangopadhyay AsokIndian Journal of Dermatology, Venereology and Leprology 2008 74(3):281-282 (Source: Indian Journal of Dermatology, Venereology and Leprology)

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ARTICLE: Primary Amenorrhea as a Manifestation of Polycystic Ovarian Syndrome in Adolescents: A Unique Subgroup?

Archives of Pediatrics — Mon, 02 Jun 2008 04:00:00 +0100

Conclusion Adolescents with PA and PCOS exhibit increased features of the metabolic syndrome and higher androstenedione levels and may represent a more severe spectrum of a common condition. (Source: Archives of Pediatrics)

Significance of acanthosis nigricans in childhood obesity

Journal of Paediatrics and Child Health — Fri, 09 May 2008 04:17:06 +0100

In this study, we aimed to find the clinical and laboratory differences in obese children with AN and without AN (non-AN). Methods: In ... (Source: Journal of Paediatrics and Child Health)

Nevoid acanthosis nigricans with subtle melanocyte hyperplasia.

Journal of the American Academy of Dermatology — Thu, 01 May 2008 04:00:00 +0100

Authors: Colegio OR, McNiff JM, Antaya RJ PMID: 18489033 [PubMed - in process] (Source: Journal of the American Academy of Dermatology)

Acanthosis nigricans

MayoClinic.com Full Feed — Fri, 21 Mar 2008 06:00:00 +0100

— Comprehensive overview covers causes, treatment of this skin condition.Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)