MedWorm: Acne

FDA Sends Letter to Sanofi Aventis Regarding Promotion for BenzaClin

Drugs.com - Pharma News — Thu, 04 Feb 2010 14:33:26 +0100

ROCKVILLE, Md., Feb. 2, 2010 - The FDA today posted on its website a letter sent to Sanofi Aventis regarding a patient brochure for acne medication BenzaClin. The letter is below. DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health... (Source: Drugs.com - Pharma News)

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Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne

The Journal of Dermatology — Wed, 03 Feb 2010 00:00:00 +0100

Acne is a very widespread cosmesis problem. Isotretinoin, a synthetic oral retinoid is used to treat acne, which is androgen dependent. Numerous side-effects occur from this treatment. 5-[alpha]-Reductase plays a critical role in normal and pathological androgen-dependent processes. We have taken the approach to develop a selective, effective, topically-applied 5-[alpha]-reductase inhibitor to modify unwanted or pathological processes in the pilosebaceous unit such as acne. Toward this goal, we have previously developed a selective liposome hair follicle targeting system. We demonstrate in this report that the 5-[alpha]-reductase inhibitor N,N-diethyl-4-methyl-3-oxo-4-aza-5[alpha]-androstane-17[beta]-carboxamide (4-MA) incorporated into liposomes induces apoptosis and inhibits growth of th...

Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074).

Gynecologic Oncology — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSION: Gefitinib, administered in combination with paclitaxel and carboplatin, provides a good clinical response but associated with an increased risk of hematologic disorders. PMID: 20109725 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?

British Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. (Source: British Journal of Dermatology)

Phase 1 Study of Combination Treatment with PTK 787/ZK 222584 and Cetuximab for Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics Analysis.

Neoplasia — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: This study shows that the combination of PTK/ZK and cetuximab is well tolerated with only slightly overlapping toxicity profiles and has antitumor activity. PMID: 20126478 [PubMed - in process] (Source: Neoplasia)

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?

The British Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. PMID: 20128787 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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BenzaClin Earns Higher Scores Than Differin for Acne Therapy

Internal Medicine News — Mon, 01 Feb 2010 00:00:00 +0100

BERLIN — Quality-of-life scores were significantly better at all time points in patients with mild to moderate acne treated with clindamycin 1% plus benzoyl peroxide 5% gel, when compared with adapalene 0.1% gel. (Source: Internal Medicine News)

Acne: Harmless Rite of Passage or Chronic Disease With Serious Effects?

Internal Medicine News — Mon, 01 Feb 2010 00:00:00 +0100

BERLIN — Acne is a condition that's widely misunderstood by nondermatologist clinicians, insurers, and patients, according to a recent call to action by the Global Alliance to Improve Outcomes in Acne, a 20-member international panel of acne experts. (Source: Internal Medicine News)

Minocycline-induced dermatomyositis

Muscle and Nerve — Fri, 29 Jan 2010 00:00:00 +0100

We report a previously healthy patient who developed a panniculitis and histopathologically proven dermatomyositis during treatment with minocycline for acne vulgaris. Her signs and symptoms resolved completely upon cessation of minocycline. This case illustrates a novel adverse effect of a widely prescribed medication. Muscle Nerve, 2010 (Source: Muscle and Nerve)

Refractory Acne and 21-Hydroxylase Deficiency in a Selected Group of Female Patients

Dermatology — Thu, 28 Jan 2010 23:00:00 +0100

Dermatology (DOI:10.1159/000277608) (Source: Dermatology)

Prevalence of Autoantibodies in SAPHO Syndrome: A Single- center Study of 90 Patients.

J Rheumatol — Thu, 28 Jan 2010 00:00:00 +0100

CONCLUSION: Our study indicates an increased prevalence of autoantibodies in SAPHO syndrome, with no specific profile. We failed to confirm the reports of an increased prevalence of antithyroid antibodies. These results tend to support a link between autoimmunity and SAPHO syndrome. PMID: 20110527 [PubMed - as supplied by publisher] (Source: J Rheumatol)

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A review of health utilities across conditions common in paediatric and adult populations

Health and Quality of Life Outcomes — Wed, 27 Jan 2010 00:00:00 +0100

Conclusions: This review highlights the need to conduct future research regarding measurement of utilities in children. (Source: Health and Quality of Life Outcomes)

Therapeutic strategies for acne and its integrated traditional and western medicine study

Chinese Journal of Integrative Medicine — Mon, 25 Jan 2010 17:05:43 +0100

Content Type Journal ArticleCategory ForumDOI 10.1007/BF02934391Authors Xi-ran Lin, Dalian Medical University Institute of Dermatology 116011 Liaoning Journal Chinese Journal of Integrative MedicineOnline ISSN 1993-0402Print ISSN 1672-0415 Journal Volume Volume 8 Journal Issue Volume 8, Number 4 / December, 2002 (Source: Chinese Journal of Integrative Medicine)

Health Tip: Caring for Acne-Prone Skin

MedlinePlus Health News — Thu, 21 Jan 2010 14:00:00 +0100

Suggestions that may help prevent outbreaks Source: HealthDay (Source: MedlinePlus Health News)

Health Tip: Caring for Acne-Prone Skin

MedicineNet Skin General — Thu, 21 Jan 2010 07:00:00 +0100

Title: Health Tip: Caring for Acne-Prone SkinCategory: Health NewsCreated: 1/21/2010 8:10:00 AMLast Editorial Review: 1/21/2010 (Source: MedicineNet Skin General)

Study Results Evaluating the Correction of Atrophic Scars with Artefill Presented at 2010 Orlando Dermatology Conference

Drugs.com - Clinical Trials — Thu, 21 Jan 2010 00:05:58 +0100

Study Suggests ArtefillÂ® Provides an Effective and Potentially Long-Lasting Treatment Option for Acne Scar Patients SAN DIEGO, Jan. 18 /PRNewswire/ -- Suneva Medical, a privately-held aesthetic medical device company, provided... (Source: Drugs.com - Clinical Trials)

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Anti-androgen Treatments.

Annales d'Endocrinologie — Thu, 21 Jan 2010 00:00:00 +0100

Authors: Bachelot A, Chabbert-Buffet N, Salenave S, Kerlan V, Galand-Portier MB 1. Estrogen plus progestin contraceptives (EPP) are the first-line treatment of moderate hirsutism and acne in women of child bearing age (grade C). 2. CPA, 50mg/day, 20 days out of 28, associated with estrogen is the first-line treatment of "moderate to severe hirsutism" in women of childbearing age (grade C). 3. Spironolactone, given as a contraceptive, can be proposed as a second-line treatment in case of side effects or counter-indications to CPA in moderate to severe hirsutism (grade C) in women of childbearing age. No market authorization in this indication. 4. Flutamide or Finasteride are "only" to be used under the guise of contraception as a "thirdline therapy" in cases of severe hirsutism, the pre...

Recommendations for investigation of hyperandrogenism.

Annales d'Endocrinologie — Thu, 21 Jan 2010 00:00:00 +0100

Authors: Pugeat M, Déchaud H, Raverot V, Denuzière A, Cohen R, Boudou P 1. Total testosterone assay is recommended as the first-line approach. 2. Radioimmunological assay following prior treatment of the sample (extraction or extraction + chromatography) is the recommended method pending wider experience with mass spectrometry. 3. Where testosterone is twice the upper limit of normal, it is recommended that DHEAS assay be performed. DHEAS is primarily of cortico-adrenal origin in women. Thus, a DHEAS level over 600 mg/dl indicates a diagnosis of androgen-secreting adrenal cortical adenoma.. If DHEAS is normal, the diagnosis could be either ovarian hyperthecosis, normally associated with insulin resistance, or androgen-secreting ovarian tumour. 4. More rarely, elevated testost...

Dehydroepiandrosterone to Enhance Physical Performance: Myth and Reality

Endocrinology and Metabolism Clinics of North America — Tue, 19 Jan 2010 14:14:33 +0100

Dehydroepiandrosterone (DHEA) is secreted by the zona reticularis of the adrenal cortex and is converted into potent sex steroids in peripheral target cells. As oral DHEA administration can lead to dose-dependent increases in circulating androgens, which may reach high supraphysiologic levels in women, it has been included in the list of prohibited substances by the World Anti-Doping Agency (WADA). However, evidence for an ergogenic activity of DHEA is still largely nonexistent. Randomized trials in elderly subjects with an age-dependent decrease in DHEA have provided little or no evidence for enhanced physical performance after long-term administration of DHEA, 50 mg/d, and smaller short-term studies in healthy male athletes using higher doses were completely negative. Thus the widely per...

Study Results Evaluating The Correction Of Atrophic Scars With Artefill Presented At 2010 Orlando Dermatology Conference

Health News from Medical News Today — Tue, 19 Jan 2010 08:00:00 +0100

Suneva Medical, a privately-held aesthetic medical device company, provided a research grant to support an investigator-sponsored research study to evaluate the degree of correction and patient satisfaction after injection of atrophic scars with Artefill. The data was presented by Dr. James Spencer, the grant recipient and study investigator, in a poster session at the 2010 Orlando Dermatology Conference taking place in Orlando, Florida January 15-18th. "Acne scarring can cause a tremendous loss of self-esteem and remains a difficult burden for affected patients," said Dr. James M... (Source: Health News from Medical News Today)

What are the Risks of Infertility after Pelvic Inflammatory Disease?

PediatricEducation.org — Mon, 18 Jan 2010 00:22:45 +0100

This study included patients 14-37 years but without subgroup analysis of adolescents. In another study, these researchers found that barrier methods (especially male condoms) significantly helped to prevent chronic pelvic pain, recurrent PID, and infertility. Questions for Further Discussion 1. What are the recommended treatment options for PID? 2. What are the recommendations for treating partners of patients with known PID and how are the partners contacted locally? 3. What are the legal requirements for treating minors with sexually transmitted infections? Related Cases Disease: Pelvic Inflammatory Disease | Chlamydia Infections Symptom/Presentation: Abdominal Pain | Pelvic Pain | Vaginal Discharge Specialty: Adolescent Medicine | Emergency Medicine | Infectious Diseases | Obstetrics...

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Epiduo 0.1%/2.5% Gel (Adapalene 1 mg/Benzoyl Peroxide 25 mg) - New product

NeLM - Dermatology — Mon, 18 Jan 2010 00:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes New cutaneous treatment of Acne vulgaris when comedones, papules and pustules are present. Epiduo should be applied to the entire acne affected areas once a day in the evening to clean and dry skin. Early signs of clinical improvement usually appear after 1 to 4 weeks of treatment. See SPC for full details (Source: NeLM - Dermatology)

Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome complicated by seven pulmonary emboli in a 15-year old patient

Journal of the American Academy of Dermatology — Fri, 15 Jan 2010 14:02:05 +0100

We report a case of a young patient with SAPHO syndrome who later presented with extensive iliofemoral deep vein thromboses and seven pulmonary emboli. (Source: Journal of the American Academy of Dermatology)

Acne management and patient support - a nursing concern for all.

British Journal of Nursing — Thu, 14 Jan 2010 00:00:00 +0100

This article outlines the principles of acne management and identifies how nurses can support acne sufferers in their clinical practice. PMID: 20081707 [PubMed - as supplied by publisher] (Source: British Journal of Nursing)

Photodynamic therapy in dermatology: basic principles

Anais Brasileiros de Dermatologia — Tue, 12 Jan 2010 14:44:12 +0100

A terapia fotodinâmica envolve a administração de uma droga fotossensibilizante e sua ativação subsequente pela luz de comprimento de onda correspondente ao espectro de absorção do fotossensibilizador. Atualmente, a terapia fotodinâmica tópica é aprovada para o tratamento de condições oncológicas cutâneas como queratoses actínicas, doença de Bowen e carcinoma basocelular superficial em diversos países do mundo. Estudos multicêntricos controlados e randomizados demonstram a alta eficácia e resultado cosmético final superior dessa modalidade terapêutica em relação aos tratamentos convencionais. Para condições cutâneas não oncológicas, como acne vulgar, verrugas virais e esclerodermia localizada, há também relatos e série de casos confirmando o potencial terapê...

A prospective, randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III

Anais Brasileiros de Dermatologia — Tue, 12 Jan 2010 14:44:12 +0100

CONCLUSIONS - Blue light irradiation was as effective as Benzoyl Peroxide in acne treatment grades II and III but there were fewer side effects. (Source: Anais Brasileiros de Dermatologia)

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NHS "should not treat problems caused by bad lifestyle"

Management in Practice — Mon, 11 Jan 2010 16:59:27 +0100

Prescriptions for common painkillers and treatment for acne should not be provided on the NHS, according to a new report (Source: Management in Practice)

Dealing with Enemies of Beautiful Skin

Health News: CBSNews.com — Sat, 09 Jan 2010 17:00:02 +0100

Dermatologist Discusses Latest Treatments for Five Common Conditions: Fine lines, Wrinkles, Eye Dark Circles, Acne, Age Spots (Source: Health News: CBSNews.com)

Dealing with Enemies of Beautiful Skin

Health News: CBSNews.com — Sat, 09 Jan 2010 17:00:02 +0100

Dermatologist Discusses Latest Treatments for Five Common Conditions: Fine lines, Wrinkles, Eye Dark Circles, Acne, Age Spots (Source: Health News: CBSNews.com)

High-tech home gadgets take aim at acne

OrlandoSentinel: Medical Research — Thu, 07 Jan 2010 00:00:00 +0100

A new crop of hand-held aesthetic devices has been crowding the bathroom shelf, wedged between the latest salon styling tool and multispeed electric toothbrush. Marketed as mini-me professional devices, the gadgets often come with hefty price tags and... (Source: OrlandoSentinel: Medical Research)

Efficacy of low-dose isotretinoin in acne vulgaris

Indian Journal of Dermatology, Venereology and Leprology — Wed, 06 Jan 2010 14:01:46 +0100

Sardana Kabir, Garg Vijay KIndian Journal of Dermatology, Venereology, and Leprology 2010 76(1):7-13Low-dose isotretinoin (0.5 mg/kg/day) is a mode of therapy for mild to moderate grades of acne.We analyzed the various trials of this mode of therapy with or without combination with topical agents.We also statistically analyzed the results, efficacy and relapse rates of standard therapy in comparison with the low-dose therapy. Our analysis of the data revealed that the efficacy and relapse rates of low-dose isotretinoin in mild to moderate grades of acne is comparable with the standard regimen (1 mg/kg/day), which is given in the severe grade of acne vulgaris. Thus, the grade of acne vulgaris should dictate the dose of administration of isotretinoin and the standard dose of 1 mg/kg/day is a...

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Spot the difference: Ban on acne advert where the models wore make-up

the Mail online | Health — Wed, 06 Jan 2010 09:29:38 +0100

A television advert for Clean & Clear Advantage Acne Control Kit has been banned because producers used makeup to enhance a before and after comparison. (Source: the Mail online | Health)

Itchy, Acne-Like Rash on a Boy’s Face and Upper Arms

Consultant Live — Tue, 05 Jan 2010 12:00:00 +0100

An 11-year-old boy with 4-month history of acnelike rash on his face and both upper arms. Rash is associated with redness and itching. (Source: Consultant Live)

January Issue of NIH News in Health Now Available

What's New on MedlinePlus — Tue, 05 Jan 2010 06:08:36 +0100

The January issue of NIH News in Health is now available. Featured stories cover how music matters to our bodies and minds and understanding acne. Also, check out the health capsules and the featured Web site. (Source: What's New on MedlinePlus)

January NIH News in Health

Midcontinental Region News — Mon, 04 Jan 2010 18:54:51 +0100

http://newsinhealth.nih.gov/ Check out the January issue of NIH News in Health, the monthly newsletter bringing you practical health news and tips based on the latest NIH research. In this edition: Strike a Chord for Health: Music Matters for Body and Mind Scientists are exploring how music can influence our bodies and minds. Ultimately, they hope to harness the power of music to develop new treatments for stroke, autism and many other conditions. Understanding Acne: How to Banish Breakouts There are many myths about what causes acne. Some people blame foods or dirty skin for their outbreaks. But there’s little evidence that either has much effect. Health Capsules: Restricting Sugary Food May Backfire Mental Disorders in Youth Featured Web Site: The Chemistry of Health [scb] (...

In vitro activities of azole antifungal agents against Propionibacterium acnes isolated from patients with acne vulgaris.

Biological and Pharmaceutical Bulletin — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Sugita T, Miyamoto M, Tsuboi R, Takatori K, Ikeda R, Nishikawa A The Gram-positive bacterium Propionibacterium acnes is the causative agent of acne vulgaris. Antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant P. acnes has been increasing. The anti-P. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. Thus, this study determined the in vitro activities of azole antifungal agents against P. acnes isolated from patients with acne vulgaris. Of the five agents tested, miconazole, ketoconazole, and itraconazole showed concentration-dependent anti-P. acnes activity, including against antib...

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[Severe drug hypersensitivity reaction (DRESS syndrome) to doxycycline.]

Annales de Dermatologie et de Cenereologie — Fri, 01 Jan 2010 00:00:00 +0100

CONCLUSION: This patient is the third case of DRESS to doxycycline described in the literature. The originality of this case lies in the allergological investigation using patch-tests and HLA determination. PMID: 20110067 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

Evaluation of the Antibacterial Activity of Rhapontigenin Produced from Rhapontin by Biotransformation against Propionibacterium acnes.

Journal of Microbiology and Biotechnology — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Kim JK, Kim N, Lim YH Biotransformation is often used to improve chemical activity. We evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with Pectinex. Rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. Activity was higher against Gram positive strains than Gram negative strains. Minimum inhibitory concentrations (MICs) of rhapontigenin, retinol, and five antibiotics were determined by microbroth dilution method for antibiotic-sensitive and -resistant Propionibacterium acnes. We also investigated the in vitro antibacterial activity of rhapontigenin in combination with antibiotic against antibiotic-resistant P. acnes. The antibiotic combination effect against resistant P. acnes was studied by checkerboard ...

Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes

Archives of Dermatological Research — Wed, 30 Dec 2009 16:44:40 +0100

This study suggests that DHT may not only be involved in sebum production but also in production of proinflammatory cytokines in acne. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-1019-6Authors Weon Ju Lee, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaHong Dae Jung, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaSeong Geun Chi, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaByung Soo Kim, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaSeok-Jong Lee, Kyung...

Reply to letter by Priori et al commenting on whether Behçet's syndrome patients with acne and arthritis comprise a true subset

Arthritis and Rheumatism — Mon, 28 Dec 2009 00:00:00 +0100

No abstract. (Source: Arthritis and Rheumatism)

Milk Consumption and Acne—Is There a Link?

Journal of the American Dietetic Association — Thu, 24 Dec 2009 14:42:45 +0100

Acne is a common and complex skin disease that affects individuals of all ages. Acne affects more than 17 million Americans, with approximately 80% to 90% of all adolescents experiencing some form of acne (). The question regarding diet and acne is not a new issue and has been debated for many years. Despite the debate, many adolescents and their parents believe that food is a primary factor. In fact, a recent survey of adolescents found that as many as 62% to 72% believed that diet was a contributing factor in acne (). Even with strong consumer beliefs regarding the food connection, medical guidelines since the 1960s and 1970s have stated that diet plays no important role in acne, and that the condition is primarily attributed to genetic predisposition and hormonal influences (). (Source:...

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Making the Case for Early Treatment of Acne

Clinical Pediatrics — Thu, 24 Dec 2009 05:44:22 +0100

Early acne can be defined as the occurrence of acne at its onset, primarily in preteens, or as acne at its earliest severity (ie, mild to moderate). Although the majority of patients with acne are treated by dermatologists, most, particularly mild to moderate cases, could be successfully managed by primary care physicians. Therefore, it is important for physicians to understand the benefits of treating all types of acne, not just the most severe. Awareness of the emotional impact of acne, particularly in adolescence, as well as recognition of possible scarring are important considerations. To achieve optimal results, physicians should be familiar with classification and severity grading of acne. Also, in-depth knowledge of available acne medications will streamline and optimize treatment r...

Genetic Susceptibility Factors in a Cohort of 38 Patients with SAPHO Syndrome: A Study of PSTPIP2, NOD2, and LPIN2 Genes.

J Rheumatol — Wed, 23 Dec 2009 00:00:00 +0100

CONCLUSION: We found no association between PSTPIP2, NOD2, and LPIN2 variants and the SAPHO syndrome. PMID: 20032092 [PubMed - as supplied by publisher] (Source: J Rheumatol)

The 'Pill' Offers Benefits Beyond Birth Control

Forbes.com Health News — Tue, 22 Dec 2009 19:00:00 +0100

Relief of menstrual pain, migraines and acne may be other reasons to prescribe, experts say (Source: Forbes.com Health News)

The 'Pill' Offers Benefits Beyond Birth Control

MedlinePlus Health News — Tue, 22 Dec 2009 19:00:00 +0100

Relief of menstrual pain, migraines and acne may be other reasons to prescribe, experts say Source: HealthDay Related MedlinePlus Topics: Birth Control, Menstruation (Source: MedlinePlus Health News)

Skin Self Defense: Pepper Spray Switches Off the Dreaded Itch Gene

PRWeb: Medical Pharmaceuticals — Tue, 22 Dec 2009 14:58:05 +0100

It’s estimated that more than 30 Million Americans suffer from chronic itching related to autoimmune diseases and topical disorders including: dermatitis, eczema, psoriasis and acne. The recent discovery of an “Itch Gene” has given scientists a new avenue to stop the itching cycle that makes most of these chronic skin conditions impossible to cure. It turns out this newly discovered gene reacts to nature’s own hot peppers via an extract known as capsaicin, and a new line of pepper body sprays claims to stop the “Itch Gene” dead in its tracks. (PRWeb Dec 22, 2009) Read the full story at http://www.prweb.com/releases/itch/gene/prweb3352264.htm (Source: PRWeb: Medical Pharmaceuticals)

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Multiple Comedonelike Lesions Encircling the Anal Orifice--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 21 Dec 2009 20:52:30 +0100

(Source: Archives of Dermatology)

Multiple Comedonelike Lesions Encircling the Anal Orifice--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 21 Dec 2009 20:52:30 +0100

(Source: Archives of Dermatology)

Treatment of Facial Scarring: Lasers, Filler, and Nonoperative Techniques

Facial Plastic Surgery — Sat, 19 Dec 2009 13:55:29 +0100

Facial plast Surg 2009; 25: 311-315DOI: 10.1055/s-0029-1243079ABSTRACTMany techniques have been described to improve facial scars. In this review we address nonoperative strategies to manage facial scarring. Scar characteristics and anatomic location are discussed. The following nonoperative techniques are comprehensively examined: pulsed dye laser (PDL), subcision, fat transplantation, collagen injection, dermabrasion, steroid injection, and fillers. The PDL is advocated to flatten and decrease the volume of hypertrophic scars while improving texture and pliability. Dermabrasion is used to blend acne scars into the surrounding facial skin by subtly improving their contour. Fat transplantation, collagen, and filler injection is recommended in the treatment of acne depressed scars and traum...

C1–C2 spondylodiscitis in an adult with SAPHO syndrome: an unusual presentation

Rheumatology International — Fri, 18 Dec 2009 16:37:12 +0100

We present a case of SAPHO syndrome with C1–C2 spondylodiscitis. Diagnosis of SAPHO syndrome was established using Khan et al. criteria (Schilling, SAPHO syndrome, Encyclopedie Orphanet, 2004). CT showed osteosclerotic lesions of dens axis. MRI sequences reveal inflammatory bone marrow oedema. Radiologists should be aware of this unusual syndrome to avoid misdiagnosis (tumour/infection), unnecessary surgery, and antibiotic therapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00296-009-1274-zAuthors Ghita Harifi, CHU Mohamed VI Service de Rhumatologie 40000 Marrakech MoroccoAhlam Belkhou, CHU Mohamed VI Service de Rhumatologie 40000 Marrakech MoroccoImane El Bouchti, CHU Mohamed VI Service de Rhumatologie 40000 Marrakech MoroccoMeryem Ouali Idrissi, CHU Mohamed VI...

Onset Therapeutics Announces Results Of BenzEFoam™ Skin Hydration Study

Health News from Medical News Today — Thu, 17 Dec 2009 19:00:00 +0100

Onset Therapeutics, a specialty pharmaceutical company focused in dermatology, today announced positive results from a skin moisturization study that compared the Company's recently launched BenzEFoam™ (benzoyl peroxide 5.3%) Emollient Foam to a market leading combination gel containing clindamycin 1% - benzoyl peroxide 5%. BenzEFoam™ Emollient Foam is indicated for the topical treatment of mild to moderate acne vulgaris and is the first prescription foam formulation containing benzoyl peroxide as the active ingredient... (Source: Health News from Medical News Today)

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The role of Propionibacterium acnes in acne pathogenesis: facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: We have come a long way since 1896, when it was first suggested that Propionibacterium acnes, found in acne lesions, was the cause of acne. Although several lines of evidence suggest the direct role of P acnes in acne, the mechanism by which P acnes contributes to the pathogenesis of acne is debated. The importance of P acnes in the induction and maintenance of the inflammatory phase of acne has been established. Emerging data that inflammatory events occur in the very earliest stages of acne development have reopened the debate about the potential involvement of this microorganism in comedogenesis and acne initiation. (Source: Clinics in Dermatology)

The role of facial sebum secretion in acne pathogenesis: facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: Increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. We have limited information about the association of sebum secretion, and the development of acne. There continues to be controversy about the role of sebum in the development of acne. This contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, facial cosmetic skin type, and acne. New therapeutic modalities for inflammatory acne aim to control seborrhea. Superficial chemical peels, laser treatment for inflammatory acne, and photodynamic therapy are used as adjunctive therapies for acne; however, their sebosuppressive effects are onl...

The role of diet in acne: facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: Acne is the most prevalent skin condition. It has a substantial effect on the quality of life of teenagers worldwide. Among acne patients from different societies and cultures, diet is uniformly regarded as a major cause in the pathogenesis of acne. We reviewed the up-to-date literature regarding acne and culprit foods such as dairy products, chocolate, and fatty foods. Unfortunately, after reviewing the existing data, there are no answers but there are definitely more questions, because there is no clear proof about whether these issues are facts or misconceptions. (Source: Clinics in Dermatology)

Hormonal therapy for acne: why not as first line therapy? facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne. (Source: Clinics in Dermatology)

The role of isotretinoin in acne therapy: why not as first-line therapy? facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: Acne is one of the most prevalent diseases in dermatology: Millions of people worldwide experience this distressing condition. To determine the appropriate therapeutic strategy, there is a strong need for a standardized classification system of acne. The exact molecular mechanism of action of isotretinoin is not completely understood; however, oral isotretinoin targets simultaneously at all major mechanisms of acne pathogenesis. Various mass media reports about the risk of teratogenicity and depression from isotretinoin usage as well as the creation of intense prevention programs have created an obstacle to the use of the most active available drug against acne, presenting isotretinoin as a very dangerous regimen. According to recommendations of several international experts, whi...

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Light and laser therapy for acne: sham or science? facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: It has long been known that light is helpful in acne. Teens recognize that summer sun diminishes pimples, and wise pharmaceutical companies (which is limiting) know that a drug trial ending in sunny months will have an elevated placebo response. (Source: Clinics in Dermatology)

Non-ablative 1550-nm erbium-glass and ablative 10 600-nm carbon dioxide fractional lasers for acne scars: a randomized split-face study with blinded response evaluation

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusion We demonstrated the efficacy and safety of single-session acne scar treatment using FPS and CO2 FS in East Asian patients. We believe that our study could be used as an essential reference when choosing laser modalities for scar treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

Diffuse Chronic Sclerosing Osteomyelitis of the Mandible With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis: Report of a Long-Term Follow-Up Case

Journal of Oral and Maxillofacial Surgery — Tue, 15 Dec 2009 14:17:46 +0100

Mandibular osteomyelitis is one of the most common infectious diseases and is usually odontogenic or traumatic in origin. Meanwhile, mandibular osteomyelitis caused by a process of unknown etiology is known to develop during the clinical course. In 1987, Chamot et al described a syndrome associated with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO syndrome), which is characterized by osteoarticular and dermatologic symptoms. The most prevalent site of bone lesions is the anterior chest wall with involvement of other locations including the sternum, clavicles, ribs, spine, and peripheral long and flat bones. Bone lesions in SAPHO syndrome demonstrate clinical and radiologic features similar to diffuse sclerosing osteomyelitis. Clinical diagnosis of SAPHO syndrome is define...

Ciclosporin/fluocortolone: Weight gain, acne, hirsutism and tremor: case report

Reactions — Tue, 15 Dec 2009 14:08:48 +0100

(Source: Reactions)

Many of the tallest mountains in North and South America contain PCBs

NaturalNews.com — Tue, 15 Dec 2009 07:00:00 +0100

(NaturalNews) Researchers from the Institute of Environmental Assessment and Water Research in Spain, the Helmholtz Centre for Environmental Research in Germany, and the University of Concepcion in Chile have identified the presence of high levels of polychlorinated biphenyls (PCBs) on mountain ranges all over North and South America. Banned worldwide since 2001, PCBs are being found at the highest levels in many of the tallest mountain ranges.Published in the journal Environmental Chemistry Letters, the discovery coincides with a similar study conducted by Swiss scientists that found other pollutants in Alpine glacial lakes that affect drinking water supplies. The PCBs found on mountaintops may eventually make their way down the mountains and pollute fields, crops, and water supplies. Som...

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Pulsed-dye and intense pulsed light laser both effective for treating acne

MedWire News - Dermatology — Fri, 11 Dec 2009 00:00:00 +0100

Pulsed-dye laser and intense pulsed light laser are both effective for treating acne lesions, show study results. (Source: MedWire News - Dermatology)

Intense pulsed light vs. pulsed-dye laser in the treatment of facial acne: a randomized split-face trial

Journal of the European Academy of Dermatology and Venereology — Fri, 11 Dec 2009 00:00:00 +0100

Conclusion Both PDL and IPL were found to treat acne effectively, but PDL showed a more sustained effect. TGF-[beta] might play a key role in the resolution of inflammatory acne lesions. (Source: Journal of the European Academy of Dermatology and Venereology)

Facial corticosteroid addictive dermatitis in Guiyang City, China

Clinical And Experimental Dermatology — Tue, 08 Dec 2009 00:00:00 +0100

In this study, FCAD was classified into five types: dermatitis (n = 109; 34.9%), acne (n = 78; 25%), rosacea (n = 64; 20.5%), angiotelectasia (n = 30; 9.6%) and dermotrophia/hyperpigmentation (n = 31; 9.9%). Improper advertisement by manufacturers, availability of steroids without prescription, improper prescribing by doctors, and patient misuse of medication has resulted in the rapid emergence of FCAD in China. Public awareness and physician and patient education of the potential side-effects of topical corticosteroids should be improved. (Source: Clinical And Experimental Dermatology)

Acne medication requires persistence

L.A. Times - Health — Sat, 05 Dec 2009 03:04:34 +0100

Drug treatment requires persistence More than 40% of teens have acne that's severe enough to require treatment by a physician, according to the American Academy of Dermatology. (Source: L.A. Times - Health)

Come on, it's just acne

L.A. Times - Health — Sat, 05 Dec 2009 03:04:33 +0100

You'd think so. But the cause of her daughter's angst was surprisingly hard to fight. Not all doctors were helpful. Overwrought at what seemed to me to be a typical smattering of pimples, my teenage daughter had been begging for months to see a dermatologist. But I'd insisted on exhausting all other approaches before going to the expense. After all, I reasoned, how hard could it be to clear up a little acne? (Source: L.A. Times - Health)

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Radiation-induced thyroid cancer: The Chicago experience

Surgery — Tue, 01 Dec 2009 00:00:00 +0100

In 1901 Karl Wilhelm Roentgen, a physics professor at Wurzburg, Germany, received the first Nobel Prize in physics for the discovery of x-rays in experiments, which began 6 years earlier in 1895. The invisible cathode rays generated were found to cause a fluorescence on a barium platinocyanide screen and, surprisingly, to outline the bones of his wife's hand on this photographic film (). By 1896, radiographs were being taken for clinical purposes and their diagnostic possibilities were quickly exploited. Bone films, chest x-rays, and even barium studies of the gastrointestinal tract were quickly tried. Roentgen found that prolonged exposure to x-rays produced burns and ulcerations of the skin, hair loss, and dermatitis. These effects were turned into therapy to burn off moles and to treat ...

Adapalene Can Be Used With Benzoyl Peroxide

Pediatric News — Tue, 01 Dec 2009 00:00:00 +0100

WASHINGTON — The newer topical retinoid adapalene is often the best front-line agent for the management of mild to moderate acne because it can be applied along with benzoyl peroxide, according to Dr. Richard J. Antaya. (Source: Pediatric News)

Assessment of general health and quality of life in patients with acne using a validated generic questionnaire.

Acta Dermatovenerologica Alpina, Panonica, et Adriatica — Tue, 01 Dec 2009 00:00:00 +0100

Conclusions: The presence of acne vulgaris per se is the most significant factor underlying patients' low perception of their general health. Patients' education about the disease and social support play a considerable role in better disease perception and can improve patients' quality of life. PMID: 20043053 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

[What's new in dermatological therapy?]

Annales de Dermatologie et de Cenereologie — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Modiano P The medical literature was reviewed to identify new dermatological therapies that appeared between October 2008 and October 2009. Randomized studies, cohort studies, metaanalyses were given priority. However, nonrandomized studies as well as clinical case studies were retained if they presented original findings. Fifty-four articles were selected on the following diseases : psoriasis, pemphigoid, pemphigus, hidradenitis, lichen, progressive systematic sclerosis, lupus, atopic dermatitis, urticaria, sexually transmitted diseases, warts, molluscum contagiosum, actinic keratoses, acne. PMID: 20110060 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

Psychological impact of isotretinoin treatment in patients with moderate and severe acne.

Collegium Antropologicum — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Simić D, Situm M, Letica E, Penavić JZ, Zivković MV, Tomić T Acne patients are subject to different degree of psychosocial distress. The emotional impact of acne vulgaris due to disfigurement caused by the disease is undisputed. Most common reactions to the acne are depression and anxiety. The use of isotretinoin, one of the most effective options in acne treatment, increases depression symptoms. The aim of this study was to investigate the psychological status of the patients with moderate to severe acne and to compare patients treated with isotretinoin with patients treated with vitamin C. A total of 85 patients suffering from acne vulgaris were included in the study. The results of this study do not find a significant correlation between the use of i...

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Efficacy of capsaicin in the treatment of acne in one case: new pathophysiological perspectives

Journal of the European Academy of Dermatology and Venereology — Mon, 30 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Detox Your Liver with These Natural Herbs

NaturalNews.com — Sat, 28 Nov 2009 07:00:00 +0100

(NaturalNews) Maybe you have a childhood memory of forgetting to clean your fish tank's filter. After all, it's easy to forget a fish tank even has a filter until it's so clogged up it starts to malfunction. Eventually, the tank is covered in slime and the health of your fish begins to fail. This scenario is much like the way we view our liver today. We often overlook the importance of the liver until it begins to adversely affect our health. However, this organ plays a vital role in cleansing, detoxifying and purification on a daily basis. The liver is also where many important nutrients are metabolized. Without a healthy liver, we cannot be healthy.If you want to keep the environment clear and healthy in your fish tank, regular filter maintenance is a must. Similarly, if you want to enjo...

11. Acne, Psoriasis, and Disorders of Keratinization

Medical and Surgical Dermatology — Wed, 25 Nov 2009 17:04:16 +0100

Content Type Journal ArticleDOI 10.1007/s00533-009-0185-z Journal Medical and Surgical DermatologyOnline ISSN 1934-2853Print ISSN 0944-5196 (Source: Medical and Surgical Dermatology)

Uncommonly reported side effects of hair removal by long pulsed-alexandrite laser

Journal of Cosmetic Dermatology — Wed, 25 Nov 2009 00:00:00 +0100

Conclusion Although the efficacy of long-pulsed alexandrite laser seems unmistakable, the short- and long-term untoward effects of such treatment have yet to be carefully delineated and the underlying mechanisms are yet to be adequately clarified. (Source: Journal of Cosmetic Dermatology)

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker.

Clinical Cancer Research — Tue, 24 Nov 2009 00:00:00 +0100

CONCLUSIONS: A significant extent of pERK inhibition was achieved for a single dose that was considered to be safe and well tolerated in healthy volunteers. (Clin Cancer Res 2009;15(23):7368-74). PMID: 19934286 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Oxidative stress in acne vulgaris

Journal of the European Academy of Dermatology and Venereology — Mon, 23 Nov 2009 00:00:00 +0100

Conclusion These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system. (Source: Journal of the European Academy of Dermatology and Venereology)

5-ALA derivative-mediated photoinactivation of Propionibacterium acnes

Journal of Dermatological Science — Sun, 22 Nov 2009 14:02:21 +0100

5-Aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) combines the administration 5-ALA which is selectively converted into the photosensitizer protoporphyrin IX (PpIX) in diseased cells, irradiation with light, and oxygen . The concerted action of these elements produces highly reactive oxygen species which, in turn, destroy cells of high PpIX content. Due to the unfavourable local bioavailability of 5-ALA, more lipophilic derivatives have been proposed, and methyl aminolevulinate (MAL) and hexyl aminolevulinate (HAL) recently gained marketing authorization . MAL is now approved for the treatment of dermatologic conditions including actinic keratosis and difficult-to-treat basal cell carcinoma. Besides its use in dermal oncology, PDT has been employed for the photodynamic inac...

Ranbaxy recalls over 4,000 cartons of acne drug in US

The Economic Times Healthcare and Biotech News — Fri, 20 Nov 2009 19:07:22 +0100

Ranbaxy Laboratories has initiated a voluntary recall of 4,348 cartons of its best-selling drug Sotret (isotretinoin, 40 mg) used to treat acne in the US, as they are a part of one batch of tablets which were found to be ‘out of specification’. (Source: The Economic Times Healthcare and Biotech News)

Ranbaxy recalls over 4,000 cartons of acne drug in US

The Economic Times Healthcare and Biotech News — Fri, 20 Nov 2009 19:07:22 +0100

Reporting clinical trials: Why one plus one does not equal two

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: We read with interest Thiboutot et al's November 2008 report of safety and efficacy of a product containing clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for treatment of acne. In the report, Thiboutot et al present combined data from two randomized controlled trials (RCTs) as if the two RCTs were in fact one large RCT. Unfortunately, such an approach is invalid. (Source: Journal of the American Academy of Dermatology)

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Photodynamic therapy for localized infections—State of the art

Photodiagnosis and Photodynamic Therapy — Thu, 19 Nov 2009 00:00:00 +0100

Summary: Photodynamic therapy (PDT) was discovered over 100 years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However, in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as a therapy for a large variety of localized infections. This revival of interest has largely been driven by the inexorable increase in drug resistance among many classes of pathogen. Advantages of PDT include equal killing effectiveness regardless of antibiotic resistance, and a lack of induction of PDT resistance. Disadvantages include the cessation of the antimicrobial effect when the light is tur...

The benzoxathiolone LYR-71 down-regulates interferon-γ-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages

British Journal of Pharmacology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions and implications: Taken together, LYR-71 could restrain IFN-[gamma]-induced inflammatory responses through uncoupling the tyrosine phosphorylation of STAT-1, an activation index of JAK[ndash]STAT-1 signalling, in macrophages. These results may provide a molecular mechanism underlying anti-inflammatory actions shown by benzoxathiolone derivatives. (Source: British Journal of Pharmacology)

International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study)

BioMed Central — Wed, 18 Nov 2009 00:00:00 +0100

DiscussionThe feasibility of the study is considered to be very high because of its similar design to the EURAS-OC study. All relevant methodological and logistical features of the study were successfully tested in the EURAS study.The chosen design minimizes the impact of referral and misclassification bias, healthy user effect and loss to follow-up. Overall, it is expected that the study design is robust enough to interpret hazard ratios of 1.5 or higher. (Source: BioMed Central)

Effect of Smooth Pulsed Light at 400 to 700 and 870 to 1,200 nm for Acne Vulgaris in Asian Skin

Dermatologic Surgery — Fri, 13 Nov 2009 00:00:00 +0100

Intense pulsed light (IPL) treatment is effective for acne in Caucasians, but no significant improvements have been observed in studies on Asian skin. To evaluate the efficacy and safety of IPL on acne vulgaris in Asian skin. Twenty-five Japanese patients, mainly of skin phototypes III or IV and moderate to severe acne, were treated five times with IPL at wavelengths of 400 to 700 nm and 870 to 1,200 nm. Results were evaluated in terms of changes in numbers of noninflammatory comedones and inflammatory papules, pustules, and cysts and acne grade before and after treatment. After the first exposure, numbers of noninflammatory and inflammatory acne lesions decreased to 36.6% and 43.0%, respectively, of their pretreatment values. After five treatments, they decreased to 12.9% and 11.7%, respe...

Skin needling shows promise for improving acne scars

MedWire News - Dermatology — Fri, 13 Nov 2009 00:00:00 +0100

Skin needling produces significant improvements in acne scarring, show results from a small, experimental study. (Source: MedWire News - Dermatology)

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Controversial acne drug available in SA

IOL: Health — Wed, 11 Nov 2009 07:51:56 +0100

While Americans have witnessed the sudden disappearance of a blockbuster acne drug, South Africans have no reason to worry. (Source: IOL: Health)

New study may deal final blow to acne drug Accutane

Los Angeles Times - Science — Sat, 07 Nov 2009 08:00:00 +0100

The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne. Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: Los Angeles Times - Science)

New study may deal final blow to acne drug Accutane

L.A. Times - Health — Sat, 07 Nov 2009 05:04:32 +0100

SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?

Arthritis Research and Therapy — Thu, 05 Nov 2009 00:00:00 +0100

SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis and osteitis, is now recognized as a distinct medical entity, a reactive infectious osteitis. Genetic, immunological and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may rise due to non complete manifestations of SAPHO: acne and arthritis, or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assman et al. is a significant addition to a long range of publications, showing an association of SAPHO with P. acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy. (Source: Arthritis Research and Therapy)

Acne: Causes, treatment and prevention

MayoClinic.com Full Feed — Wed, 04 Nov 2009 02:45:01 +0100

Acne — Comprehensive overview covers causes, acne treatments, including adult acne treatments, and prevention. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

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Too old for acne? At 30, Rebecca thought she was past the age for spots

the Mail online | Health — Tue, 03 Nov 2009 00:19:00 +0100

Adults acne is a growing problem. Occurring mostly in women, one recent study estimated that 14 per cent of those aged between 26 and 44 in the UK suffer from acne. (Source: the Mail online | Health)

Skin Tightening Effect Using Fractional Laser Treatment: I. A Randomized Half-Side Pilot Study on Faces of Patients with Acne

Dermatologic Surgery — Tue, 03 Nov 2009 00:00:00 +0100

Fractional laser resurfacing is a new procedure for skin rejuvenation. To assess the skin remodeling effect of fractional laser treatment. Twelve Asian patients with acne were irradiated using a fractional 1,540-nm erbium glass laser on a random half of the face twice with a 4-week interval. The faces were contoured on the treated side of most patients. Statistical analyses of the facial images showed that the skin tightening effect was significant 4 weeks after the first and second irradiation (p (Source: Dermatologic Surgery)

Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

Minimally ablative fractional laser devices have gained acceptance as a preferred method for skin resurfacing. Notable improvements in facial rhytides, photodamage, acne scarring, and skin laxity have been reported. The aim of the present work was to compare how different CO2 laser fluences, by modulating the secretory pathway of cytokines, are able to influence the wound-healing process, and how these fluences are associated with different clinical results. Eighteen patients, all with photodamaged skin, were treated using a fractional CO2 laser (SmartXide DOT, Deka M.E.L.A., Florence, Italy) with varying laser fluences (2.07, 2.77, and 4.15 J/cm2). An immunocytochemical study was performed at defined end points in order to obtain information about specific cytokines of the microenvironmen...

Effaclar Acne Spot Treatment

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

La Roche-Posay's Effaclar AI Intensive Acne Spot Treatment is available to reduce stubborn and inflammatory acne in as few as 3 days. The formulation includes a 5.5% concentration of micronized benzoyl peroxide to clear inflammatory acne, as well as 0.4% LHA (lipohydroxy acid), which is a lipophilic derivative of salicylic acid that micro-exfoliates the skin and stimulates cell renewal to help even the skin tone, including residual skin marking. The product is oil free and noncomedogenic, and has been tested on sensitive skin. (Source: Skin and Allergy News)

Personalized OTC Acne Care

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

Neutrogena's Skin ID regimen is available to treat and help prevent acne. The three-product, over-the-counter system is offered as an alternative to antibiotics for those who are concerned about building resistance to antibiotic treatments. Customers can complete an online skin evaluation that will direct them to a gel cleanser, an acne treatment, and a moisturizer “personalized” to fit their skin condition. The regimen includes salicylic acid, benzoyl peroxide, and a proprietary MicroClear technology to deliver the medication deep into pores; the system retails for about $40. (Source: Skin and Allergy News)

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Sun Defense Kit for Acne-Prone Skin

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

Acne patients may be at increased risk for sun sensitivity and skin damage, depending on their treatment regimen. The Avidoxy DK defence kit offers products that provide sun protection for acne suffers without exacerbating their condition. The kit consists of 100-mg doxycycline tablets (available by prescription only) to help destroy acne-causing bacteria, plus two free products: defence acne wash and defence solare SPF 30. The acne wash contains 2% salicylic acid to promote cleansing and exfoliation, and it is oil-free and alcohol-free. The defence solare SPF is an oil-free, noncomedogenic, moisturizing sunblock that contains antioxidants and zinc oxide to provide broad-spectrum sun protection for acne-prone skin. (Source: Skin and Allergy News)

Acne and Systemic Disease

Medical Clinics of North America — Sun, 01 Nov 2009 00:00:00 +0100

Acne is the most common skin disease. It normally occurs during adolescence as a result of excess production of hormones. However, acne may be associated with assorted endocrine disorders, nonendocrine diseases, and the use of certain medications. These causes of acne are discussed in this article along with basic therapeutic interventions. (Source: Medical Clinics of North America)

Acne and Systemic Disease.

The Medical Clinics of North America — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Lolis MS, Bowe WP, Shalita AR Acne is the most common skin disease. It normally occurs during adolescence as a result of excess production of hormones. However, acne may be associated with assorted endocrine disorders, nonendocrine diseases, and the use of certain medications. These causes of acne are discussed in this article along with basic therapeutic interventions. PMID: 19932324 [PubMed - as supplied by publisher] (Source: The Medical Clinics of North America)

Treatment of Hidradenitis Suppurativa with Tumour Necrosis Factor-alpha Inhibitors.

Acta Derm Venereol A... — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Haslund P, Lee RA, Jemec GB Hidradenitis suppurativa (HS) is a common inflammatory skin disease. Medical treatment is often disappointing and in severe disease surgery remains the therapy of choice. Extensive surgery may be effective but also mutilating. Patients experience a significant reduction in quality of life and the need for new treatment modalities are urgent. In recent years patients with HS have been treated off-label with tumour necrosis factor-alpha (TNF-alpha) inhibitors with a varying degrees of effect. We performed a systematic review of papers retrieved from two databases (PubMed and Web of Science) using the follow-ing keywords: hidradenitis suppurativa, acne inversa, infliximab, etanercept, and adalimumab. A total of 34 publications were retrieved, describin...

Benzoyl peroxide and adapalene fixed combination: a novel agent for acne.

The British Journal of Dermatology — Thu, 29 Oct 2009 15:18:25 +0100

Authors: Layton AM, Eady EA PMID: 19857206 [PubMed - in process] (Source: The British Journal of Dermatology)

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ACG: Acne Drug Tied to IBD (CME/CE)

MedPage Today Gastroenterology — Thu, 29 Oct 2009 13:00:25 +0100

SAN DIEGO (MedPage Today) -- Use of the acne medication isotretinoin (Accutane) is associated with an increased risk of inflammatory bowel disease, researchers said here. (Source: MedPage Today Gastroenterology)

Acne vulgaris und Seborrhoe, Rosacea, Psoriasis vulgaris, Parapsoriasis, Lupus erythematodes

Dermatology — Wed, 28 Oct 2009 23:00:00 +0100

Dermatologica 1948;95:91-101 (DOI:10.1159/000255936) (Source: Dermatology)

Uncommon etiology of an anterior chest wall mass.

The Annals of Thoracic Surgery — Tue, 27 Oct 2009 12:29:52 +0100

Authors: Schwartz GS, Rios L, Zivin-Tutela T, Bhora FY, Connery CP A rare but important constellation of musculoskeletal and cutaneous symptoms, including synovitis, acne, pustulosis, hyperostosis, and osteitis, has recently been designated the SAPHO syndrome. The exact etiology is unknown, although various infectious agents have been proposed. The most common site of osteoarticular involvement is the sternoclavicular joint, and therefore, recognition of this syndrome and appropriate workup and management is crucial in the differential diagnosis of an anterior chest wall mass. PMID: 19853079 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

The individual health burden of acne: Appearance-related distress in male and female adolescents and adults with back, chest and facial acne

Journal of Health Psychology — Mon, 26 Oct 2009 16:37:51 +0100

This study examined appearance-related distress in patients with acne. One hundred and thirty-two people attending a specialist acne clinic completed questionnaires including the Derriford Appearance Scale and three self-rated acne scales covering more (facial) and less visible (chest, back) acne sites. Women with acne demonstrated greater self-consciousness of appearance and negative self-concept than men. Subjective rating of severity of facial acne was significantly associated with increased social self-consciousness in women, but not in men. Back acne was significantly associated with sexual and bodily self-consciousness of appearance in both men and women. Patients 20 years and above were significantly more likely to suffer appearance-related distress than 16—19-year-olds. Altho...

Acne in women: clinical patterns in different age-groups

Anais Brasileiros de Dermatologia — Fri, 23 Oct 2009 12:59:34 +0100

CONCLUSION: Chronologic and topographic patterns of female acne in different age-groups were defined, reinforcing the importance of an individualized diagnostic and therapeutic approach. (Source: Anais Brasileiros de Dermatologia)

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Management of acne vulgaris: an evidence-based update

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with standard topical treatments. Long-term topical tretinoin to prevent nonmelanoma skin cancer in elderly men was associated with higher all-cause mortality, but there is c...

Immune reconstitution inflammatory syndrome involving the skin

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions. New skin lesions were very common in this cohort, with the majority being women and patients with very low baseline CD4 counts. (Source: Clinical And Experimental Dermatology)

Uncommon Etiology of an Anterior Chest Wall Mass [CASE REPORTS]

The Annals of Thoracic Surgery — Thu, 22 Oct 2009 18:54:54 +0100

A rare but important constellation of musculoskeletal and cutaneous symptoms, including synovitis, acne, pustulosis, hyperostosis, and osteitis, has recently been designated the SAPHO syndrome. The exact etiology is unknown, although various infectious agents have been proposed. The most common site of osteoarticular involvement is the sternoclavicular joint, and therefore, recognition of this syndrome and appropriate workup and management is crucial in the differential diagnosis of an anterior chest wall mass. (Source: The Annals of Thoracic Surgery)

With Microdermabrasion, Rough Seems to Work Better

MedlinePlus Health News — Wed, 21 Oct 2009 13:00:00 +0100

Acne scars and wrinkles benefit from more aggressive treatment, study finds Source: HealthDay Related MedlinePlus Topic: Plastic and Cosmetic Surgery (Source: MedlinePlus Health News)

RESEARCH LETTERS: Physician Workforce for Acne Care in the United States, 2003 Through 2005

Archives of Dermatology — Mon, 19 Oct 2009 19:52:13 +0100

(Source: Archives of Dermatology)

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Physician Workforce for Acne Care in the United States, 2003 Through 2005 [Research Letters]

Archives of Dermatology — Mon, 19 Oct 2009 19:52:13 +0100

(Source: Archives of Dermatology)

Dusa targets skin cancer to blunt downturn’s effects

bizjournals.com Health Care:Health Insurance headlines — Mon, 19 Oct 2009 04:00:00 +0100

The downturn has been particularly cruel to laser dermatology companies, which often rely on nonessential treatments that patients must pay for out of pocket. Companies with laser treatments for acne, hair removal and the like have faced the double whammy of patients tightening purse strings and doctors who are hamstrung by the credit crunch and can’t purchase the latest equipment. (Source: bizjournals.com Health Care:Health Insurance headlines)

Dusa targets skin cancer to blunt downturn’s effects

bizjournals.com Health Care:Biotechnology headlines — Mon, 19 Oct 2009 04:00:00 +0100

A case of SAPHO syndrome with destructive spondylodiscitis suspicious of tuberculous spondylitis

Modern Rheumatology — Thu, 15 Oct 2009 06:00:15 +0100

We report a rare case of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in which the differential diagnosis included tuberculous spondylitis and the patient ultimately required reconstructive spinal surgery. The patient was a 60-year-old woman who presented with severe low-back and leg pain after treatment for tuberculosis. Roentgenography and magnetic resonance imaging of the lumbar spine revealed destructive changes suggestive of tuberculous spondylitis. [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography showed uptake in the cervical spines, lumbar spines, and sacroiliac joints from which she was suspected of having SAPHO syndrome without skin manifestations. However, as her symptoms did not respond to conservative treatment, we perfor...

II. Zur Kenntnis der Pathogenese der Perifolliculitis capitis abscedens et suffodiens (E. Hoffmann) und ihrer Beziehungen zur Acne conglobata

Dermatology — Wed, 14 Oct 2009 23:00:00 +0100

Dermatologische Zeitschrift 1928;51:94-107 (DOI:10.1159/000251817) (Source: Dermatology)

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Natural remedies for acne

NaturalNews.com — Wed, 14 Oct 2009 07:00:00 +0100

(NaturalNews) Acne sucks. But you don't need antibiotics or harsh chemicals to treat it. In addition to altering your diet so that you consume fewer acne-producing foods (dairy products and fried foods, mostly), there are some effective natural remedies that are also useful for clearing up your skin.Below, we've compiled a few of these recommendations from some of the top authors in natural health. Enjoy this short collection, and feel free to share it with others (please give appropriate credit to the original author as well as this NaturalNews page, thank you).Natural remedies for acneBrazilian school kids have acne. There's far less acne in Kenya, Zambia, Malaysia, and rural Japan than is common in Western societies. But if there was any doubt left about the diet-acne connection it shou...

Quality of Sexual Life in Hyperandrogenic Women Treated with an Oral Contraceptive Containing Chlormadinone Acetate

The Journal of Sexual Medicine — Tue, 13 Oct 2009 23:00:00 +0100

Conclusion(s). The EE/CMA pill has anti-androgenic properties reducing the anti-aesthetic effect of hyperandrogenism and improving female sexual and social self-esteem. Caruso S, Rugolo S, Agnello C, Romano M, and Cianci A. Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)

New Study Assesses Skin Hydration And Epidermal Function Of 2.5% And 5% Benzoyl Peroxide-Clindamycin Combinations

Drugs.com - Clinical Trials — Tue, 13 Oct 2009 13:01:27 +0100

Las Vegas, NV – October 15, 2009 – Dermatologists agree that topical fixed-combination products containing clindamycin (clin) and benzoyl peroxide (BPO) are effective in the treatment of acne. However, products containing BPO... (Source: Drugs.com - Clinical Trials)

Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro

International Journal of Cosmetic Science — Sat, 10 Oct 2009 23:00:00 +0100

The synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro. All probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition was significantly (P < 0.01) enhanced by the presence of the GMH prebiotic. As the current treatment of acne is based on topical or systemic drugs, it is worth examining further the biotherapeutic activities of the GMH and selected probiotics with a view to future use as prophylactic or therapeutic synbiotics for treating acne infections. La capacité synbiotic des bactéries probiotic et des hydrolysats glucomannan konjac (GMH) d'empêcher l'acné - induisant des bactérie, la croissance d'acn�...

Antibiotics Control SAPHO Syndrome, but Symptoms Recur When Therapy Stops

Medscape Rheumatology Headlines — Thu, 08 Oct 2009 17:32:02 +0100

Although SAPHO syndrome - which stands for synovitis, acne, pustulosis, hyperostosis, and osteomyelitis - responds to antibiotics, discontinuing the medication leads to relapse, German researchers report in the September 21st online issue of Arthritis Research and Therapy. Reuters Health Information (Source: Medscape Rheumatology Headlines)

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New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome

Current Rheumatology Reports — Tue, 06 Oct 2009 12:59:21 +0100

Abstract In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propionibacterium acnes, the microorganism associated with acne, has been recovered on bone biopsy in some patients, but the possible pathogenetic role of an infectious agent in...

Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathways

Journal of Dermatological Science — Mon, 05 Oct 2009 16:28:46 +0100

Conclusion: Our results indicate that nicotinamide inhibits IL-8 production through the NF-κB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Keratinocytes involved in the innate immune response may be a suitable target for treatment during the early phase of inflammation. (Source: Journal of Dermatological Science)

Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosis

Journal of Orthopaedic Science — Sat, 03 Oct 2009 06:33:48 +0100

Conclusions On the basis of our findings, we propose using a patient questionnaire and protocol for investigating and managing patients who present with NBO to orthopedic surgeons. We predict that this will benefit patients with this disorder by improving our knowledge of the presenting signs and symptoms and related disorders, rationalizing the therapeutic approach, and allowing us to learn about the natural history of the disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1381-4Authors Panagiotis D. Gikas, Bone Tumour Unit, Royal National Orthopaedic Hospital Stanmore, Middlesex UKLily Islam, Royal National Orthopaedic Hospital Department of Histopathology Stanmore, Middlesex UKWilliam Aston, Bone Tumour Unit, Royal National Orthop...

11. Acne, Psoriasis, and Disorders of Keratinization

Medical and Surgical Dermatology — Sat, 03 Oct 2009 06:33:24 +0100

Content Type Journal ArticleDOI 10.1007/s00533-009-0166-2 Journal Medical and Surgical DermatologyOnline ISSN 1934-2853Print ISSN 0944-5196 (Source: Medical and Surgical Dermatology)

50 years ago from the Connecticut State Medical Journal. October 1959. Radiation therapy of acne.

Connecticut Medicine — Thu, 01 Oct 2009 00:00:00 +0100

Authors: Strauss JS PMID: 19860280 [PubMed - in process] (Source: Connecticut Medicine)

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Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents

Journal of the European Academy of Dermatology and Venereology — Wed, 30 Sep 2009 23:00:00 +0100

Conclusion Photodynamic therapy of acne vulgaris using 5-ALA 0.5% liposomal spray and IPL in combination with topical peeling agents is safe and efficacious, even in patients with acne recalcitrant to standard therapy. (Source: Journal of the European Academy of Dermatology and Venereology)

[Pandalao and skin whitening in Mayotte.]

Annales de Dermatologie et de Cenereologie — Wed, 30 Sep 2009 23:00:00 +0100

DISCUSSION: Although illegal, the trade in skin whitening products continues to grow because it is profitable and takes full advantage of the success of ethnic cosmetics. In Mayotte, as in metropolitan France and Africa, the existence of SW is acknowledged but is still taboo. However, a number of specific characteristics are seen in Mayotte: SW is rarely performed on the whole body, salicylic acid is added to a topical corticosteroid, and the traditional Mahoran mask, the "mzindzano", is still worn for photoprotection. PMID: 19801250 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

Multimodal Treatment of Acne, Acne Scars and Pigmentation

Dermatologic Clinics — Wed, 30 Sep 2009 23:00:00 +0100

This article reviews the causes of acne, the treatment options, and grading scales. (Source: Dermatologic Clinics)

Nonablative Fractional Laser Resurfacing

Dermatologic Clinics — Wed, 30 Sep 2009 23:00:00 +0100

This article discussed the science, clinical indications, patient selection and preparation, posttreatment care, and complications of NFR. It concludes that the most impressive clinical results are seen with acne scars, surgical and traumatic scars, and mild to moderate facial and nonfacial dyschromia or photoaging. Modest results can be seen with therapy-resistant melasma and certain types of rhytides. Future approaches include synergistic treatments with radiofrequency devices and the development of novel wavelengths to enhance the efficacy of NFR while preserving safety. (Source: Dermatologic Clinics)

Emerging Technologies in Aesthetic Medicine

Dermatologic Clinics — Wed, 30 Sep 2009 23:00:00 +0100

Recent advances in technology have drastically improved aesthetic treatment for skin. Of particular interest is the emergence of laser- and lightbased technologies, which have offered great promise among skin-rejuvenation therapies. New laser resurfacing techniques for skin rejuvenation offer significant advantages over conventional ablative lasers, such as the CO2 and erbiumYAG laser systems. Nonablative and fractional lasers, although not as efficacious as ablative therapies, are associated with significantly diminished complication rates and shortened recovery times. Novel devices combining ablative and fractional technologies have also surfaced, demonstrating noteworthy results. In this review, the authors will discuss the implications of current developments in research and technology...

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Health advice: 'Is there a cure for a son who's uncommunicative and sullen?'

The Telegraph : Health Advice — Wed, 30 Sep 2009 16:05:12 +0100

Britain's leading health and wellbeing specialists answer your questions: This week: an uncommunicative son. (Source: The Telegraph : Health Advice)

Fact Checking Anecdotes: Obama Wrong On Particulars In Cancer And Acne Insurance Denial Case

Health News from Medical News Today — Wed, 30 Sep 2009 12:00:00 +0100

When President Obama recently recounted the story of a woman he said was denied coverage for failure to own up to a skin condition when she enrolled in a plan, he was incorrect, The Associated Press reports. "Robin Lynn Beaton, 59, of Waxahachie, Texas, indeed had her insurance suspended and then terminated when she needed it the most. (Source: Health News from Medical News Today)

Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris

Karger Publishers — Tue, 29 Sep 2009 23:00:00 +0100

Case Rep Dermatol 2009;1:49-51 (DOI:10.1159/000236034) (Source: Karger Publishers)

Fractional photothermolysis—an update

Lasers in Medical Science — Tue, 29 Sep 2009 07:33:03 +0100

Abstract The novel concept of non-ablative fractional photothermolysis was introduced to the market in 2003 as an answer to the need for effective, yet low risk, resurfacing techniques. Unlike conventional ablative and non-ablative lasers, fractional ablative and non-ablative photothermolysis treats only a fraction of the skin, leaving up to a maximum of 95% of the skin uninvolved. The undamaged surrounding tissue allows for a reservoir of viable tissue, permitting rapid epidermal repair. Non-ablative fractional photothermolysis is currently approved by the US Food and Drug Administration (FDA) for the treatment of pigmented lesions, periorbital rhytides, skin resurfacing, melasma and soft tissue coagulation, acne and surgical scars, and actinic keratoses. However, its off...

FACT CHECK: In health debate, Obama's stories of hardship don't always hold up to scrutiny

OrlandoSentinel: Medical Research — Mon, 28 Sep 2009 23:09:00 +0100

WASHINGTON (AP) — One of President Barack Obama's health care "horror stories" is about a woman who, he says, lost her health insurance on the verge of breast cancer surgery because she didn't disclose a case of acne to the insurer. That's not... (Source: OrlandoSentinel: Medical Research)

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Management of cutaneous side-effects of cetuximab therapy in patients with metastatic colorectal cancer

Journal of the European Academy of Dermatology and Venereology — Sat, 26 Sep 2009 23:00:00 +0100

Conclusion During the treatment with EGFRI, it is necessary to recognize and manage adverse reactions promptly to assure better patient quality of life and allowing continuation of therapy without dose reduction or drug discontinuation. (Source: Journal of the European Academy of Dermatology and Venereology)

Birth control pills for acne?

MayoClinic.com Full Feed — Wed, 23 Sep 2009 01:45:02 +0100

Birth controls pills for acne may be helpful in some women. Learn more. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

Birth control pills for acne?

MayoClinic.com - Ask a Specialist — Tue, 22 Sep 2009 05:00:00 +0100

Birth controls pills for acne may be helpful in some women. Learn more. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com - Ask a Specialist)

Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: interventional study

Arthritis Research and Therapy — Sun, 20 Sep 2009 23:00:00 +0100

Conclusions: For the period of application, the antibiotic therapy seems to have controlled the disease. After antibiotics discontinuation however, disease relapse was observed. SAPHO syndrome thus groups with other chronic inflammatory arthropathies with a need of permanent therapy. (Source: Arthritis Research and Therapy)

OBSERVATION: Interaction of Topical Sulfacetamide and Topical Dapsone With Benzoyl Peroxide

Archives of Dermatology — Sun, 20 Sep 2009 23:00:00 +0100

Conclusions Knowledge of the chemical reaction between benzoyl peroxide and sulfacetamide and dapsone will help minimize the occurrence of this interaction on our patients' skin. (Source: Archives of Dermatology)

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Poor diet may increase risk for acne in adolescent girls

MedWire News - Pediatrics — Sat, 19 Sep 2009 17:00:47 +0100

Results from a Norwegian study indicate that adolescent girls who rarely eat raw, fresh vegetables may be at increased risk for acne. (Source: MedWire News - Pediatrics)

Teen Acne and Depression: Can Mood Worsen Skin?

TIME.com: Top Science and Health Stories — Fri, 18 Sep 2009 16:15:00 +0100

A survey of Norwegian teenagers finds that depression and acne often appear together. Could kids' mood be affecting the blemishes on their skin? (Source: TIME.com: Top Science and Health Stories)

Poor diet may increase risk for acne in adolescent girls

MedWire News - Dermatology — Fri, 18 Sep 2009 00:00:00 +0100

Results from a Norwegian study indicate that adolescent girls who rarely eat raw, fresh vegetables may be at increased risk for acne. (Source: MedWire News - Dermatology)

Efficacy and safety profiles of cetuximab in Chinese patients with colorectal cancer

The Chinese-German Journal of Clinical Oncology — Thu, 17 Sep 2009 12:25:10 +0100

Conclusion This study is the first study to summarize the data of Chinese patients with colorectal cancer treated by cetuximab-contained regimen, it showed that the monoclonal antibody was effective and safe for Chinese patients as the West patients with colorectal cancer. Content Type Journal ArticleDOI 10.1007/s10330-009-0062-2Authors Liangping Xia, Sun Yat-sen University, National Laboratory of Oncology in South China VIP Region, Cancer Center Guangzhou 510060 ChinaGuifang Guo, Sun Yat-sen University, National Laboratory of Oncology in South China VIP Region, Cancer Center Guangzhou 510060 ChinaHuijuan Qiu, Sun Yat-sen University, National Laboratory of Oncology in South China VIP Region, Cancer Center Guangzhou 510060 ChinaBei Zhang, Sun Yat-sen University, Nation...

Acne Really Is A Nightmare For Some Teens

Health News from Medical News Today — Thu, 17 Sep 2009 10:00:00 +0100

Zits, pimples, bumps and blemishes are a young person's worst nightmare. Collectively they are known as acne, a very common skin condition that affects millions of adolescents. Now a Norwegian study published in the open access journal BMC Public Health has investigated the links between acne, diet and mental health issues in both males and females. (Source: Health News from Medical News Today)

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Less chocolate, more veggies may help acne

Health News - UPI.com — Wed, 16 Sep 2009 18:24:48 +0100

OSLO, Norway, Sept. 16 (UPI) -- Researchers in Norway have made associations between acne, high intake of chocolate and chips and low intake of vegetables. (Source: Health News - UPI.com)

Is the association between acne and mental distress influenced by diet? Results from a cross-sectional population study among 3775 late adolescents in Oslo, Norway.

BMC Public Health - Latest articles — Tue, 15 Sep 2009 23:00:00 +0100

Conclusions: Among late adolescents in Oslo, self-reported acne is significantly associated with mental distress and, among girls, with infrequent consumption of raw vegetables. Our finding does not support the hypothesis that dietary factors alter the relationship between acne and mental distress. (Source: BMC Public Health - Latest articles)

Acne really is a nightmare for some teens

EurekAlert! - Social and Behavioral Science — Tue, 15 Sep 2009 04:00:00 +0100

(BioMed Central) Zits, pimples, bumps and blemishes are a young person's worst nightmare. Collectively they are known as acne, a very common skin condition that affects millions of adolescents. Now a Norwegian study published in the open access journal BMC Public Health has investigated the links between acne, diet and mental health issues in both males and females. (Source: EurekAlert! - Social and Behavioral Science)

Expression of tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase-3 in proliferated synovium in a patient with synovitis-acne-pustulosis-hyperostosis-osteitis syndrome: a case report

Journal of Medical Case Reports — Mon, 14 Sep 2009 23:00:00 +0100

Conclusion: We demonstrate the expression of TNF-alpha converting enzyme, TNF-alpha and matrix metalloproteinase-3 in SAPHO syndrome synovitis for the first time and also show, both macro- and microscopically, the similarity between SAPHO syndrome and rheumatoid arthritis synovitis. These new findings support the recently reported successful treatment of SAPHO syndrome with antirheumatic drugs, especially with anti-TNF-alpha agents. (Source: Journal of Medical Case Reports)