MedWorm: Allergy

Role of IL-4 in aversion induced by food allergy in mice.

Cellular Immunology — Sun, 21 Mar 2010 17:54:03 +0100

Authors: Dourado LP, Saldanha JC, Gargiulo DL, Noviello Mde L, Brant CC, Reis ML, Souza RM, Faria AM, Souza Dda G, Cara DC To ascertain the role of IL-4 in aversion to antigen induced by food allergy, wild type and IL-4 deficient BALB/c mice were sensitized with ovalbumin and challenged orally with egg white. Sensitized wild type mice had increased production of IL-4 by spleen and mesenteric lymph node cells in vitro, higher levels of serum anti-ovalbumin IgE and IgG1, aversion to ingestion of the antigen and loss of body weight after continuous oral challenge. Intestinal changes in wild type sensitized mice included eosinophil infiltration and increased mucus production. The IL-4 deficiency impaired the development of food allergy and the aversion to antigen, suggesting the involvemen...

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Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis.

Cellular Immunology — Sun, 21 Mar 2010 17:54:03 +0100

Authors: Lee JH, Noh J, Noh G, Kim HS, Mun SH, Choi WS, Cho S, Lee S B cells have regulatory functions in immune responses. Antigen-specific responses of B cell subsets by allergen stimulation ex vivo were examined in milk allergy of late eczematous reactions. Eight milk allergy subjects and 13 milk tolerant subjects were selected by DBPCFC. PBMCs were stimulated by casein ex vivo and stained for B cell subsets using monoclonal antibodies. CD19+ B cells unchanged from 8.7+/-3.8% to 8.0+/-5.1% (p=0.504, n=8) in the milk allergy group and decreased in the milk tolerant group from 8.5+/-3.2% to 5.0+/-1.6% (p=0.001, n=13). The fraction of apoptotic B cells in B cells significantly decreased 4.4+/-3.1% to 1.3+/-0.4% (p=0.027, n=4) in the allergy group and insignificantly increased from 2.8+...

Wheat-dependent exercise-induced anaphylaxis exclusively during menstruation

Allergy — Sun, 21 Mar 2010 00:00:00 +0100

(Source: Allergy)

Video: Mighty Solutions to Dust Mites

Health News: CBSNews.com — Sat, 20 Mar 2010 17:41:59 +0100

Home and lifestyle expert Laura Dellutri taught Kaylee Hartung and Lonnie Quinn how to keep their allergies at bay with preventative measures against dust mites in the bedroom and germs in the kitchen. (Source: Health News: CBSNews.com)

Spring Cleaning Allergens Out of Your Home

Health News: CBSNews.com — Sat, 20 Mar 2010 16:30:03 +0100

"Healthy Housekeeper" Laura Dellutri Shows How to Rid Your Home of Pollen, Dust, Dirt, Microscopic Allergy-Causers (Source: Health News: CBSNews.com)

Video: Spring Allergy Busters

Health News: CBSNews.com — Sat, 20 Mar 2010 15:41:11 +0100

April usually brings allergies to about 40 million Americans. House & Lifestyle expert, Laura Dellutri shows us the ultimate spring cleaning to rid your home of pollen, dust and dirt. (Source: Health News: CBSNews.com)

Scientific Data Relating To Cinryze(TM) (C1 Esterase Inhibitor [Human]) Presented At International Congress Of The Southern European Allergy Society

Health News from Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

ViroPharma Incorporated (Nasdaq: VPHM) announced the presentation of two abstracts relating to Cinryze™ (C1 esterase inhibitor [human]) therapy at the First International Congress of the Southern European Allergy Society in Florence, Italy. Cinryze was approved by the U.S. Food and Drug Administration in October 2008 for routine prophylaxis against hereditary angioedema (HAE) attacks in adults and adolescents. Cinryze is not approved in the European Union or any of its member states... (Source: Health News from Medical News Today)

Scientific Data Relating To Cinryze(TM) (C1 Esterase Inhibitor [Human]) Presented At International Congress Of The Southern European Allergy Society

Allergy News From Medical News Today — Sat, 20 Mar 2010 08:00:00 +0100

Allergic contact dermatitis from ethylhexyl salicylate and other salicylates.

Dermatitis — Sat, 20 Mar 2010 00:42:50 +0100

This article describes allergic contact dermatitis from ethylhexyl salicylate used as an ultraviolet filter and fragrance compound and reviews the published literature on contact allergy to salicylates. PMID: 20233542 [PubMed - in process] (Source: Dermatitis)

Infection of infants with human herpesvirus type 6 may be associated with reduced allergic sensitization and T-helper type 2 development

Clinical and Experimental Allergy — Sat, 20 Mar 2010 00:00:00 +0100

Epidemiological studies point to an inverse relationship between microbial exposure and the prevalence of allergic diseases. The underlying mechanism for this observation remains largely unknown, as well as the nature of the microbes involved. To investigate the effects of early infection with human herpesviruses (HHVs) on IgE formation and T-helper type 2 (Th2) development in infants. Serum was collected from children aged 18 months and assessed for IgE to common allergens and IgG to five common herpesviruses. Cord blood plasmacytoid dendritic cells (pDC) were exposed to HHV type 6 in vitro and mixed with allogeneic cord blood CD4+ T cells. Cytokine levels were determined by ELISA and by flow cytometry. We found that children seropositive at 18 months of age to HHV type 6 were significant...

Skin prick test to horse should be included in the standard panel for the diagnosis of respiratory allergy.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

Authors: Liccardi G, Salzillo A, Piccolo A, D'Amato G PMID: 20232783 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Monosensitivity to pangasius and tilapia caused by allergens other than parvalbumin.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

Authors: Ebo DG, Kuehn A, Bridts CH, Hilger C, Hentges F, Stevens WJ Fish allergy is one of the most common food allergies in populations where fish is a major part of the diet. Most fish-allergic patients react to the panallergen parvalbumin present in multiple fish species. Our aim was to investigate the clinical case of a patient with oral allergy syndrome to pangasius and Nile tilapia but tolerance of other fish and seafood. The temporal relationship between fish consumption and allergic symptoms, the positive skin prick tests, and the basophil activation test results for both fish species strongly supported the diagnosis of an immunoglobulin (Ig) E-mediated allergy. This was confirmed by the detection of specific IgE to 18-kDa and 45-kDa proteins in immunoblot analysis. Notably, t...

Edema of the uvula: etiology, risk factors, diagnosis, and treatment.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

Authors: Alcoceba E, Gonzalez M, Gaig P, Figuerola E, Auguet T, Olona M Edema of the uvula (EU) is a rare occurrence sometimes associated with angioedema, urticaria, and anaphylaxis. We analyze the causes, predisposing factors, and characteristics of EU in a group of 58 patients with a mean (SD) age of 48.2 (15.2) years over the course of a year. Of the 58 patients studied, 49 (84.5%) were male and 44 (75.9%) presented isolated EU. Thirty-two patients (55.1%) with no clear etiology were classed as idiopathic. Snoring and a high body mass index were more prevalent in these patients. A variety of probable causes were identified in 26 patients (44.9%). In this group, EU was usually accompanied by urticaria, angioedema, and anaphylaxis and there was also a greater prevalence of atopy. We f...

Maintenance venom immunotherapy administered at a 3-month interval preserves safety and efficacy and improves adherence.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

CONCLUSIONS: The study confirms that the conventional MVIT interval of 4 to 6 weeks can be extended to 3 months in most patients with no adverse events, while maintaining safety and efficacy, improving adherence, and guaranteeing safe continuation of professional activity. PMID: 20232775 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Efficacy of venom immunotherapy in beekeepers.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

CONCLUSION: To our knowledge, this study is the first to provide data on the experience of beekeepers who continue their activity after desensitization. Our results show that desensitization can result in a complete absence of symptoms after re-exposure to bee stings. PMID: 20232774 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Preliminary results of a skin prick test-based study of the prevalence and clinical impact of hypersensitivity to pollen panallergens (polcalcin and profilin).

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

CONCLUSIONS: The clinical relevance of hypersensitivity to pollen panallergens is often limited; many allergic patients have symptoms only during the central period, suggesting primary grass sensitization. Profilin-allergic patients often do not corecognize pellitory and cypress pollen. In vivo component-resolved diagnosis of seasonal respiratory allergies is a promising approach that might lead to cost reduction and a faster definition of pollen-allergic cases. PMID: 20232772 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

CONCLUSIONS: Patients with rhinoconjunctivitis diagnosed using skin prick testing with a grass mix allergen extract and treated with a short course of SIT based on a single species P. pratense allergen extract are able to develop an immune response that targets not only the immunizing species, but also the grass mix allergen extract. PMID: 20232769 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum

Journal of Medical Genetics — Fri, 19 Mar 2010 17:53:07 +0100

Conclusion We provide evidence of a novel splice variant of the DNA-PKcs gene associated with radiosensitivity in a patient with xeroderma pigmentosum and report the first double mutant in distinct DNA repair pathways being consistent with viability. (Source: Journal of Medical Genetics)

How to Fight Off Seasonal Allergies

Health News: CBSNews.com — Fri, 19 Mar 2010 17:30:03 +0100

Dr. Jennifer Ashton Gives Checklist to Arm Spring Sufferers (Source: Health News: CBSNews.com)

Peanut allergy linked to increased asthma morbidity in children

MedWire News - Pediatrics — Fri, 19 Mar 2010 16:11:55 +0100

The presence of peanut allergy is associated with a greater number of hospitalizations and increased systemic steroid use in children with asthma, research shows. (Source: MedWire News - Pediatrics)

Postoperative management following sphincter pharyngoplasty

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:37 +0100

Conclusion: Upper airway obstruction requiring overnight observation following SP is uncommon. In otherwise healthy patients, performing SP in an outpatient setting, given appropriate recovery room evaluation for airway concerns, oral intake, and pain control, should be considered. (Source: Otolaryngology - Head and Neck Surgery)

Video: Prepping for Spring Allergies

Health News: CBSNews.com — Fri, 19 Mar 2010 14:30:05 +0100

Dr. Jennifer Ashton gave important tips for allergic individuals to prepare for the Spring allergy season. (Source: Health News: CBSNews.com)

Video: Prepping for Spring Allergies

Health News: CBSNews.com — Fri, 19 Mar 2010 14:30:05 +0100

Dr. Jennifer Ashton gave important tips for allergic individuals to prepare for the Spring allergy season. (Source: Health News: CBSNews.com)

Subjective memory problems

BMJ Online First — Fri, 19 Mar 2010 12:25:32 +0100

(Source: BMJ Online First)

How to Fight Off Seasonal Allergies

Health News: CBSNews.com — Fri, 19 Mar 2010 12:19:14 +0100

Dr. Jennifer Ashton Gives Checklist to Arm Spring Sufferers (Source: Health News: CBSNews.com)

Dr Miriam Stoppard Speaks On Baby And Child Nutrition, England

Health News from Medical News Today — Fri, 19 Mar 2010 08:00:00 +0100

Visitors to a conference on food allergies were given an insight into the life of leading children's doctor and broadcaster, Dr. Miriam Stoppard, at the University of Portsmouth yesterday. Dr Stoppard, who is a medical doctor and well-known to millions as a leading authority on parenting, child care and women's health, was the keynote speaker at the conference organised by the School of Health Sciences and Social Work (SHSSW)... (Source: Health News from Medical News Today)

Dr Miriam Stoppard Speaks On Baby And Child Nutrition, England

Allergy News From Medical News Today — Fri, 19 Mar 2010 08:00:00 +0100

Prenatal Stress May Boost Baby's Asthma Risk

MedicineNet Allergies General — Fri, 19 Mar 2010 07:00:00 +0100

Title: Prenatal Stress May Boost Baby's Asthma RiskCategory: Health NewsCreated: 3/18/2010 12:10:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Allergies General)

A Contemporary Update on Scleroderma

Clinical Reviews in Allergy and Immunology — Fri, 19 Mar 2010 06:52:16 +0100

Content Type Journal ArticleDOI 10.1007/s12016-010-8200-8Authors Loïc Guillevin, Referral Center for Rare Autoimmune Disease: vasculitis and systemic sclerosis, Hôpital Cochin Department of Internal Medicine 27 rue du Faubourg Saint-Jacques 75014 Paris France Journal Clinical Reviews in Allergy and ImmunologyOnline ISSN 1559-0267Print ISSN 1080-0549 (Source: Clinical Reviews in Allergy and Immunology)

Television Star Alison Sweeney Joins ZYRTEC® to Welcome the Arrival of Spring with the 'Race Against Your Allergies'(Mar 19, 2010)

Johnson and Johnson — Fri, 19 Mar 2010 06:04:14 +0100

Ft. Washington, PA (March 19 2010) -- Allergy sufferer and actress Alison Sweeney today joined the makers of the fastest 24-hour over-the-counter (OTC) allergy medicine, ZYRTEC®,for an unusual race to officially welcome the first day of spring and new ZYRTEC® Liquid Gels. The "Race Against Your Allergies," which took place in New York City's Madison Square Park, featured some unusual runners – six, five-foot-tall noses representing some of allergy sufferers' worst symptoms, giving them the chance to "outrun" them this season..... (Source: Johnson and Johnson)

Critical illness as a result of influenza A/H1N1 infection in pregnancy

BMJ Online First — Fri, 19 Mar 2010 00:05:36 +0100

(Source: BMJ Online First)

Acupuncture transmitted infections

BMJ Online First — Fri, 19 Mar 2010 00:05:33 +0100

(Source: BMJ Online First)

Peanut allergy linked to increased asthma morbidity in children

MedWire News - Respiratory — Fri, 19 Mar 2010 00:00:00 +0100

The presence of peanut allergy is associated with a greater number of hospitalizations and increased systemic steroid use in children with asthma, research shows. (Source: MedWire News - Respiratory)

Immunologic analysis and serum heavy metal levels in exacerbated Tourette syndrome

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Hsieh M-Y, Lee W-I, Lin K-L, Hung P-C, Chou M-L, Chang M-Y, Huang J-L, Wang H-S. Immunologic analysis and serum heavy metal levels in exacerbated Tourette syndrome. Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Tourette syndrome (TS) is a childhood-onset and relapsing disorder characterized by involuntary simple or complex tics and high co-morbidity with behavioral anomalies. Its pathophysiologic mechanisms remain unclarified. We investigated immunologic alternations and serum heavy metal levels in patients with TS to elucidate the unclarified mechanisms. Based on the Yale Global Tic Severity Scale, fifteen TS subjects (four females) aged 8[ndash]34 (mean: 15.4 ± 6.7) in exacerbation with mean severity score 40.3 ± 14.6 were enrolled in this study. The immunoglobulin levels ...

Properdin in childhood and its association with wheezing and atopy

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Staley KG, Kuehni CE, Strippoli MPF, McNally T, Silverman M, Stover C. Properdin in childhood and its association with wheezing and atopy.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Properdin, a serum glycoprotein, is an important component of innate immunity, the only known positive regulator of complement, acting as an initiation point for alternative pathway activation. As an X-linked protein, we hypothesized that properdin may play a modulatory role in the pathogenesis of viral wheeze in children, which tends to be more common and more severe in boys. We aimed to determine properdin levels in a community-based paediatric sample, and to assess whether levels of properdin were associated with childhood wheeze phenotypes and atopy. We studied 137 school-children aged 8[ndas...

Serum levels of heavy metals in childhood eczema and skin diseases: Friends or foes

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Hon K-LE, Wang SS, Hung ECW, Lam HS, Lui HHK, Chow C-M, Ching GKW, Fok T-F, Ng P-C, Leung T-F. Serum levels of heavy metals in childhood eczema and skin diseases: Friends or foes.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S The incidence of eczema has been increasing in developed countries. Environmental and hygiene factors have been incriminated. Although air and food pollution with heavy metals have been considered as possible culprits, these factors have never been investigated in Hong Kong. To evaluate if quality of life and eczema severity are associated with abnormal serum levels of six common heavy metals, namely, cadmium, lead, mercury, selenium, copper and zinc. Serum or whole blood was taken for measurement of six heavy metals from patients referred to the pediatric...

Indoor allergen exposure, sensitization, and development of asthma in a high-risk birth cohort

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Carlsten C, Dimich-Ward H, Becker AB, Ferguson A, Chan HW, DyBuncio A, Chan-Yeung M. Indoor allergen exposure, sensitization, and development of asthma in a high-risk birth cohort.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Contradictory findings have been observed for the association of house dust mite (HDM), cat, and dog allergen exposure with sensitization and asthma. We sought to determine the relationship between exposures to these allergens, at various points during early childhood, and specific sensitization and asthma at age 7 in a high-risk birth cohort. As part of a multi-faceted Canadian intervention program for the primary prevention of asthma in high-risk infants, children were assessed by pediatric allergists at age 7 for asthma and underwent allergy skin prick...

Specific profiles of house dust mite sensitization in children with asthma and in children with eczema

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Shek LP, Chong AR, Soh SE, Cheong N, Teo ASM, Yi FC, Giam YC, Chua KY, Van Bever HP. Specific profiles of house dust mite sensitization in children with asthma and in children with eczema.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Sensitization to house dust mites (HDM) is highly prevalent among the young atopic population in Singapore. Previously published data suggest that individuals with skin allergies show preferred sensitization to Dermatophagoides pteronyssinus while individuals with pure respiratory allergies show preferred sensitization to Blomia tropicalis. The aim of our study was to compare the sensitization profiles between children with asthma and those with eczema to D. pteronyssinus and B. tropicalis and their specific allergens. A total of 60 children, 30 w...

Lower interleukin-8 levels in airway aspirates from breastfed infants with acute bronchiolitis

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Dixon D-L, Griggs KM, Forsyth KD, Bersten AD. Lower interleukin-8 levels in airway aspirates from breastfed infants with acute bronchiolitis.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/SJournal compilation © 2010 Blackwell Munksgaard Breastfeeding during the first 12 months of life confers demonstrable immunologic benefit against infective pathogens, including those of the respiratory tract. However, the mechanism by which the ingestion of human milk modifies immunologic defense against such pathogens remains elusive. Bronchiolitis, caused predominantly by respiratory syncytial virus, is the most common clinical presentation of severe upper respiratory illness requiring hospitalization in infants and remains one of the developed world's leading causes of infant mortality and ...

Prevalence of asthma and allergic diseases in primary school children in Edirne, Turkey, two surveys 10 years apart

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Selcuk ZT, Demir AU, Tabakoglu E, Caglar T. Prevalence of asthma and allergic diseases in primary school children in Edirne, Turkey, two surveys 10 years apart.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S To assess change in prevalence and risk factors of asthma and allergic diseases among primary school children in rural and urban parts of Edirne, Turkey, a series of cross-sectional studies were conducted in 1994 and 2004. A questionnaire was administered to the parents of primary school children aged 7[ndash]12, in urban and rural parts of Edirne, Turkey (5412 in 1994 and 5735 in 2004). Response rates in 1994 and 2004 were 84% and 82.5%, respectively. There were significant differences between the age distribution, urban habitation (1994: 70.1%, 2004: 75.8%, p < 0.001), pas...

Pediatric common variable immunodeficiency: Immunologic and phenotypic associations with switched memory B cells

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

We examined the relationship between switched memory B cells and clinical and immunologic manifestations of CVID in a pediatric population. Forty-five patients were evaluated. Patients were categorized as Group I ( (Source: Pediatric Allergy and Immunology)

Cord blood molecular biomarkers of eosinophilopoiesis: Kinetic analysis of GATA-1, MBP1 and IL-5Rα mRNA expression

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Ellis AK, Ackerman SJ, Crawford L, Du J, Bedi R, Denburg JA. Cord blood molecular biomarkers of eosinophilopoiesis: Kinetic analysis of GATA-1, MBP1 and IL-5R[alpha] mRNA expression.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Eosinophil/basophil (Eo/B) progenitor phenotype and function in cord blood (CB) are associated with atopic risk at birth and infant clinical outcomes. Molecular analyses of eosinophil[ndash]basophil differentiation events could identify clinically predictive biomarkers. To determine CB kinetic patterns of Eo/B lineage-associated gene expression (GATA-1, MBP1 and IL-5R[alpha]) after IL-5 stimulation, CB non-adherent mononuclear cells were isolated from random fresh and frozen samples and incubated in the presence of recombinant human interleukin-5. Some ...

Perinatal nutrition and immunity to infection

Pediatric Allergy and Immunology — Fri, 19 Mar 2010 00:00:00 +0100

Jones KDJ, Berkley JA, Warner JO. Perinatal Nutrition and Immunity to Infection.Pediatr Allergy Immunol 2010.© 2010 John Wiley & Sons A/S Epidemiological data provide strong evidence for a relationship between undernutrition and life-threatening infection in infants and children. However, the mechanisms that underlie this relationship are poorly understood. Through foetal life, infancy and childhood, the immune system undergoes a process of functional maturation. The adequacy of this process is dependent on environmental factors, and there is accumulating evidence of the impact of pre- and post-natal nutrition in this regard. This review outlines the impact of nutrition during foetal and infant development on the capacity to mount immune responses to infection. It provides an overview of ...

Times report - electronic health records contain 'life-threatening errors'

NeLM - News — Fri, 19 Mar 2010 00:00:00 +0100

Source: The Times Area: News According to a report by the Times online, a draft report on the Summary Care Record (SCR) reveals that the new national electronic patient records database contains serious errors and omissions. Researchers from University College London, who are reviewing the project for the Department of Health, found examples where the database failed to indicate allergies or adverse reactions to drugs, and listed medication that the patient wasn't taking. So far, about 12 million patients in England have been sent leaflets about the new SCR and about 1.2 million electronic records have been uploaded. The draft review found no evidence that incomplete or inaccurate data on the database had led to patient harm, but suggests this was due to doctors not trust...

Effects of enzymatic hydrolysis on lentil allergenicity

Molecular Nutrition — Fri, 19 Mar 2010 00:00:00 +0100

In this study, lentil protein extract was hydrolyzed by sequential action of an endoprotease (Alcalase) and an exoprotease (Flavourzyme). Immunoreactivity to raw and hydrolyzed lentil extract was evaluated by means of IgE immunoblotting and ELISA using sera from five patients with clinical allergy to lentil. The results indicated that sequential hydrolysis of lentil results in an important proteolytic destruction of IgE-binding epitopes shown by in vitro experiments. However, some allergenic proteins were still detected by sera from four out of five patients in the last step of sequential hydrolyzation. (Source: Molecular Nutrition)

Macadamia nut allergy: potentially misleading specific IgE results

Allergy — Fri, 19 Mar 2010 00:00:00 +0100

(Source: Allergy)

Increased urinary biopyrrins in patients with asthma

Allergy — Fri, 19 Mar 2010 00:00:00 +0100

(Source: Allergy)

Medical Therapy in Chronic Rhinosinusitis

Current Allergy and Asthma Reports — Thu, 18 Mar 2010 18:32:46 +0100

Content Type Journal ArticleCategory Clinical Trial ReportDOI 10.1007/s11882-010-0100-8Authors Marek L. Kowalski, Medical University of Lódz Department of Immunology, Rheumatology, and Allergy, Faculty of Medicine 251 Pomorska Street 92-213 Lódz Poland Journal Current Allergy and Asthma ReportsOnline ISSN 1534-6315Print ISSN 1529-7322 (Source: Current Allergy and Asthma Reports)

Asthma UK Comment On Research Linking Pre-natal Stress And Asthma Development In Young Children

Health News from Medical News Today — Thu, 18 Mar 2010 16:00:00 +0100

This study is important as it suggests that a newborn with a family history of asthma or allergy will respond more strongly to asthma triggers if their mothers have higher stress levels during pregnancy... (Source: Health News from Medical News Today)

Mesenteric vasculitis causing ileocecal intussusception as the initial presentation of systemic lupus erythematosus: a case report

Clinical Rheumatology — Thu, 18 Mar 2010 15:36:07 +0100

Abstract Mesenteric vasculitis is one of the most devastating complications of systemic lupus erythematosus (SLE) and may produce a spectrum of complications, including ulceration, hemorrhage, bowel necrosis, perforation, serositis, and ascites. Intussusception is a process in which a segment of intestine invaginates into the adjoining intestinal lumen, causing bowel obstruction. Intussusception in association with SLE has rarely been reported. Here we report a case of SLE whose initial presentation was mesenteric vasculitis causing ileocecal intussusception. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10067-010-1421-7Authors Yeong-Jang Lin, Chi-Mei Medical Center Division of Allergy, Immunology and Rheumatology No. 901, Zhonghua Rd Yongkang City Tain...

Dangerous Allergens: Why Some Allergens are Bad Actors

Current Allergy and Asthma Reports — Thu, 18 Mar 2010 15:26:19 +0100

Abstract Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway epithelial cells and dendritic cells are key components of the innate immune system in the nose and lung and are now known to be intimately involved in allergen recognition and in modulating allergic immune responses. Here we review current thinking about how these two key cell types sense and respond to inhaled allergens, and emphasize how an understanding of “allergic innate immunity” can translate into new thinking about mechanisms of allergen se...

Warfarin alternative 'prevents more strokes'; Geographical variation in pollen-related allergies; Varenicline effective even in failed smoking quitters

Pulse — Thu, 18 Mar 2010 13:26:00 +0100

Our update on the latest research being presented at medical conferences. (Source: Pulse)

Warfarin alternative 'prevents more strokes'; Geographical variation in pollen-related allergies; Varenicline effective even in failed smoking quitters

Pulse Today Clinical Updates — Thu, 18 Mar 2010 13:26:00 +0100

Our update on the latest research being presented at medical conferences. (Source: Pulse Today Clinical Updates)

FDA Advisory Committee Recommends Approval Of InterMune's Esbriet(R) (pirfenidone) For Idiopathic Pulmonary Fibrosis

Health News from Medical News Today — Thu, 18 Mar 2010 11:00:00 +0100

InterMune, Inc. (Nasdaq: ITMN) announced that the U.S. Food and Drug Administration's (FDA) Pulmonary-Allergy Drugs Advisory Committee (PADAC) voted 9-3 to recommend approval of Esbriet® (pirfenidone) for the treatment of patients with idiopathic pulmonary fibrosis (IPF) to reduce decline in lung function. IPF is a rare and fatal lung disease that affects approximately 200,000 people in the United States and Europe. If approved by the FDA for commercialization, Esbriet would be the first medication to be made available to IPF patients in the United States... (Source: Health News from Medical News Today)

FDA Advisory Committee Recommends Approval Of InterMune's Esbriet(R) (pirfenidone) For Idiopathic Pulmonary Fibrosis

Pharma Industry News From Medical News Today — Thu, 18 Mar 2010 11:00:00 +0100

Dr Reddy's gets FDA nod for Allegra generic

The Economic Times Healthcare and Biotech News — Thu, 18 Mar 2010 10:10:11 +0100

Dr Reddy's Laboratories has received the US Food and Drug Administration's approval to launch the generic version of Sanofi-Aventis' allergy drug Allegra, a spokesman said on Thursday. (Source: The Economic Times Healthcare and Biotech News)

Allergic To Aspirin, Penicillin, Other Medicines? Montefiore Program Helps Patients With Adverse Drug Reactions

Allergy News From Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

Allergic To Aspirin, Penicillin, Other Medicines? Montefiore Program Helps Patients With Adverse Drug Reactions

Health News from Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

A Westchester patient takes aspirin for pain, but develops rashes and hives. A Bronx patient with a gastrointestinal problem caused by bacteria is prescribed penicillin, then passes out. A Bronx woman is given a contrast dye for an internal diagnostic exam, then her skin peels off. All of these patients suffered severe adverse drug reactions and were referred to a new specialty service, the Drug Desensitization Program at Montefiore Medical Center, the only such program in the Metro New York region. "Adverse drug reactions are at least as common as food allergies... (Source: Health News from Medical News Today)

Sun Pharma gets US nod for Prometh generic

The Economic Times Healthcare and Biotech News — Thu, 18 Mar 2010 08:14:29 +0100

Sun Pharmaceutical Industries Ltd said on Thursday the US Food and Drug Administration approved its generic version of Actavis Mid Atlantic's Prometh syrup, used to treat cold, flu and allergies. (Source: The Economic Times Healthcare and Biotech News)

Stress During Pregnancy Linked to Higher Risk for Asthma in Offspring

Medscape Allergy Headlines — Thu, 18 Mar 2010 05:30:45 +0100

In an inner-city cohort, prenatal stress was associated with changes in innate and adaptive immune responses that could affect the expression of allergic disease. Medscape Medical News (Source: Medscape Allergy Headlines)

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Clinical and Molecular Allergy — Thu, 18 Mar 2010 00:00:00 +0100

We examined HLA-DR and HLA-DQ frequencies in Alternaria-sensitive asthmatic by HLA typing. To determine ratios of Th1/Th2 Alternaria-specific T-cells, cultures were stimulated in media alone, Alternaria alternata extract and Alt a1. Sensitivity to IL-4 stimulation was measured by up-regulation of CD23 on B cells. Results: Children with Alternaria-sensitive moderate-severe asthma trended to have increased sensitivities to Cladosporium (46% versus 35%), to Aspergillus (43% versus 28%), and significantly increased sensitivities to trees (78% versus 57%) and to weeds (68% versus 48%). The IL-4RA ile75val polymorphism was significantly increased in Alternaria-sensitive moderate-severe asthmatics, 83% (0.627 allele frequency) compared to Alternaria-sensitive mild asthmatics, 57% (0.388 allele fr...

Identification of methionine synthase (Sal k 3), as a novel allergen of Salsola kali pollen.

Molecular Biology Reports — Thu, 18 Mar 2010 00:00:00 +0100

Authors: Assarehzadegan MA, Sankian M, Jabbari F, Tehrani M, Falak R, Varasteh A Salsola kali pollen is a common cause of pollinosis during summer and early fall in desert and semi-desert regions. The aim of this study was the identification and characterization of Sal k 3, a new allergen from S. kali pollen. S. kali pollen extract was fractionated by SDS-PAGE and the allergenic profile was determined by IgE-immunoblotting using twelve S. kali allergic patients. Protein identification was carried out by the means of mass spectrometry. Using degenerated primers, two DNA fragments encoding N- and C-terminal domain of Sal k 3 were amplified by PCR, then cloned into the PTZ57R/T vector and sequenced. The open reading frame of Sal k 3 fragments were subcloned in the pET-32b(+) vector, expre...

Determination of irritant threshold concentrations to weeds, trees and grasses through serial dilutions in intradermal testing on healthy clinically nonallergic dogs.

Veterinary Dermatology — Wed, 17 Mar 2010 16:36:21 +0100

Authors: Bauer CL, Hensel P, Austel M, Keys D Irritant threshold concentration (ITC) for intradermal testing (IDT) was determined in 31 healthy, clinically nonallergic dogs. Twenty-three allergens were tested at five variable concentrations ranging from 1000 to 8000 PNU/mL. To distinguish irritant reactions from subclinical IgE-mediated hypersensitivities, serum allergy testing was performed. ITCs were determined by evaluating the lowest concentration to which no dogs (0% cut-off) and to which at least 10% of dogs (>/=10% cut-off) reacted. ITCs at the 0% cut-off were: 1000 PNU/mL (Johnson grass), 2000 PNU/mL (Ash, Lamb's Quarter and Bermuda), 3000 PNU/mL (Bahia, Rye, Pig Weed and Virginia Oak), 4000 PNU/mL (Marsh Elder and Maple), 5000 PNU/mL (Sorrel sheep) and 7000 PNU/mL (Cocklebu...

iTRAQ-based proteomic identification of leucine-rich {alpha}-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases

Annals of the Rheumatic Diseases — Wed, 17 Mar 2010 14:46:00 +0100

Conclusions LRG represents a novel serum biomarker for monitoring disease activity during therapy in autoimmune patients, particularly useful in patients with active disease but normal CRP levels. (Source: Annals of the Rheumatic Diseases)

Synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression: analysis of a proof-of-concept randomised clinical trial of cytokine blockade