MedWorm: Alopecia Areata

Cytokines and Other Mediators in Alopecia Areata

Mediators of Inflammation — Thu, 11 Mar 2010 17:39:13 +0100

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-γ, interleukins, TNF-α, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments. (Source: Mediators of Inflammation)

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Dermatoglyphic patterns in psoriasis, vitiligo and alopecia areata

Indian Journal of Dermatology, Venereology and Leprology — Thu, 11 Mar 2010 14:10:55 +0100

Kumar Pramod, Gupta AtulaIndian Journal of Dermatology, Venereology, and Leprology 2010 76(2):185-186 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Clinical Picture of the Week: Alopecia areata

Pulse Today Clinical Updates — Thu, 04 Mar 2010 17:02:00 +0100

This award-wnning picture shows a 14-year-old girl with an unusual case of alopecia areata. (Source: Pulse Today Clinical Updates)

Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion Our study demonstrates that vitiligo is a part of systemic autoimmune process. Audiological examination should be performed in all patients for auditory problems which are commonly presented as hypoacusis. (Source: Journal of the European Academy of Dermatology and Venereology)

Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors

Journal of the American Academy of Dermatology — Tue, 16 Feb 2010 14:09:36 +0100

To the Editor: We previously reported that alopecia areata (AA), an autoimmune disease targeting the hair follicle causing hair loss, had a 55% concordance rate in monozygotic twins, suggesting both genetic and environmental triggers. Recently, we also reported a possible association between Epstein–Barr virus (EBV)-related mononucleosis and onset of AA in 12 young individuals. To further study the role of genes versus environment in the pathogenesis of AA, we examined concordance rates for AA and exposure to EBV by IgG serology in a new cohort of twins from the National Alopecia Areata Registry. (Source: Journal of the American Academy of Dermatology)

Hypnosis in refractory alopecia areata significantly improves depression, anxiety, and life quality but not hair regrowth

Journal of the American Academy of Dermatology — Tue, 16 Feb 2010 14:09:35 +0100

To the Editor: Our preliminary results on the use of hypnosis in alopecia areata (AA), previously published in the JAAD, have suggested the possible efficacy of hypnosis in refractory AA forms. However, from the research finding of our latest study, another message emerges. In this prospective cohort study, a hypnotherapeutic approach was used without any other treatment, to compare the evolution of anxiety, depression, and health-related quality of life (HRQOL) of patients with AA that was refractory to conventional treatment, with control patients receiving only treatment for AA as usual. Only patients and controls presenting more than 30% hair loss with a minimal duration of 3 months were included. For ethical reasons, a nonrandomized controlled study protocol was selected. (Source: Jou...

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Systematic approach to hair loss in women

JDDG — Sat, 23 Jan 2010 00:00:00 +0100

Diffuse hair loss is a common complaint and cause of significant emotional distress particularly in women. The best way to alleviate the anxiety is to effectively treat the hair loss. It is paramount to address the symptom systematically. In addition to its psychological impact, hair loss may be a manifestation of a more general medical problem. The diagnosis can be established with a detailed patient history focussing on chronology of events, examination of the scalp and pattern of hair loss, a pull test with examination of bulbs of shed hairs, trichoscopy, and few pertinent screening blood tests. In selected cases a scalp biopsy may be required. The most important differential diagnoses include acute and chronic telogen effluvium, female pattern hair loss, and diffuse alopecia areata. Oc...

Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis

Journal of the American Academy of Dermatology — Fri, 15 Jan 2010 14:01:59 +0100

Alopecia areata (AA) is an autoimmune disease that presents as nonscarring hair loss, although the exact pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer clinical variants have been described. The presence of AA is associated with a higher frequency of other autoimmune diseases. Controversially, there may also be increased psychiatric morbidity in patients with AA. Although some AA features are known poor prognostic signs, the course of the disease is unpredictable and the response to treatment can be variable. Part one of this two-part series ...

Alopecia areata update: Part II. Treatment

Journal of the American Academy of Dermatology — Fri, 15 Jan 2010 14:01:59 +0100

Various therapeutic agents have been described for the treatment of alopecia areata (AA), but none are curative or preventive. The aim of AA treatment is to suppress the activity of the disease. The high rate of spontaneous remission and the paucity of randomized, double-blind, placebo-controlled studies make the evidence-based assessment of these therapies difficult. The second part of this two-part series on AA discusses treatment options in detail and suggests treatment plans according to specific disease presentation. It also reviews recently reported experimental treatment options and potential directions for future disease management.Learning objectives: After completing this learning activity, participants should be able to compare the efficacy and safety of various treatment option...

Topical Bexarotene for Hair Regrowth in Alopecia Areata

Medscape Dermatology Headlines — Wed, 13 Jan 2010 05:32:22 +0100

Spontaneous and sudden hair loss is traumatic and refractory to therapy. Will topical bexarotene offer hope for hair regrowth in these patients? Medscape Dermatology (Source: Medscape Dermatology Headlines)

Natural killer cells in atopic and autoimmune diseases of the skin

Journal of Allergy and Clinical Immunology — Fri, 01 Jan 2010 00:00:00 +0100

Natural killer (NK) cells are best known for their ability to recognize and kill tumor cells and virally infected cells and for their ability to produce large amounts of some cytokines, such as IFN-γ. Recent research has substantially expanded our view on the function of NK cells in the immune system in health and disease. In addition to the better-studied functions in cancer and autoimmunity, contributions from NK cells to allergies and various skin diseases have emerged. We briefly recount the traditional NK cell functions before focusing on their roles in atopic dermatitis, psoriasis, alopecia areata, and pemphigus vulgaris. Although this field is still developing, strong data are available that indicate NK cell involvement. In patients with allergic diseases, the production of TH2 cyt...

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Vogt-Koyanagi-Harada syndrome: Association with alopecia areata.

Dermatol Online J — Thu, 31 Dec 2009 16:04:02 +0100

We present a case of VKH syndrome and propose that the alopecia and poliosis described in the original reports by ophthalmologists could instead be alopecia areata with re-growth of white hair. PMID: 20040260 [PubMed - in process] (Source: Dermatol Online J)

Follicular Red Dots: A Novel Dermoscopic Pattern Observed in Scalp Discoid Lupus Erythematosus [Observation]

Archives of Dermatology — Mon, 21 Dec 2009 20:52:29 +0100

Conclusions The follicular red dot pattern is a specific feature of scalp lesions of active lupus erythematosus of the scalp. Recognition of this distinctive dermoscopic pattern may help the clinician to differentiate DLE from other diseases causing cicatricial alopecia. (Source: Archives of Dermatology)

Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusions Latanoprost may be an effective drug in the treatment of eyelash AA because it induces acceptable responses (total and moderate) in 45% of the patients. A formal, blinded prospective unilateral controlled study will permit further understanding about this promising therapeutic agent for eyelash AA. (Source: Journal of the European Academy of Dermatology and Venereology)

The TRAF1/C5 locus confers risk for familial and severe alopecia areata

British Journal of Dermatology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusions Our results point to the involvement of the TRAF1/C5 locus in the aetiology of familial and severe AA, and provide further support for a shared aetiology between AA and other autoimmune disorders. (Source: British Journal of Dermatology)

The TRAF1/C5 locus confers risk for familial and severe alopecia areata.

The British Journal of Dermatology — Thu, 17 Dec 2009 00:00:00 +0100

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Diabetic ketoacidosis, thyroiditis and alopecia areata in a child with down syndrome

Indian Journal of Pediatrics — Sat, 12 Dec 2009 14:30:41 +0100

Abstract A 10-year-old girl with Down syndrome and alopecia areata was admitted with severe ketoacidosis. She had high blood glucose level: 615 mg/dL and her HbAlc level was 13.3 %. After the control of ketoacidosis and reduction of the plasma glucose level, we found low free T4 level and high TSH levels. Thyroid peroxidase antibodies titer was 1383 IU/mL and both gliadin and endomysial antibodies were negative. This was the first report of a child with Down syndrome showing type 1 diabetes combined with alopecia areata and autoimmune thyroid disease. Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-009-0242-7Authors Ozgur Pirgon, Konya Research and Training Hospital Department of Pediatric Endocrinology Konya TurkeyMehmet Emre Atabek, Selcuk Univer...

Complementary and Alternative Medicine in Alopecia Areata

American Journal of Clinical Dermatology — Sat, 12 Dec 2009 13:58:41 +0100

(Source: American Journal of Clinical Dermatology)

Young sisters who lost their hair cast off their wigs and go to school bald for the first time

the Mail online | Health — Wed, 09 Dec 2009 08:08:18 +0100

Emily Sandford, 11, and nine-year-old Faye both have alopecia areata, a condition where the body’s immune system mistakenly attacks follicles. (Source: the Mail online | Health)

Alopecia syphilitica-report of a patient with secondary syphilis presenting as moth-eaten alopecia and a review of its common mimickers.

Dermatol Online J — Thu, 03 Dec 2009 20:46:04 +0100

Authors: Bi MY, Cohen PR, Robinson FW, Gray JM Alopecia syphilitica is an uncommon manifestation of secondary syphilis, occurring in only 4 percent of these individuals. It is non-inflammatory and non-cicatricial hair loss that can present in a diffuse pattern, a moth-eaten pattern, or a combination of both. A 38-year-old, otherwise asymptomatic, homosexual man is described whose initial presentation of syphilis was patchy, moth-eaten, alopecia. In addition, differentiating features of alopecia syphilitica and other similar appearing non-cicatricial alopecias are reviewed. Conditions that mimic moth-eaten alopecia include other localized and non-cicatricial alopecias, such as alopecia areata, alopecia neoplastica, tinea capitis, and trichotillomania. The distinguishing clinical and lab...

[What's new in paediatric dermatology?]

Annales de Dermatologie et de Cenereologie — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Mazereeuw-Hautier J The literature review for 2009 covers the principal themes of the speciality and brings new findings in the fields of pathophysiology, clinical features, therapeutical approaches. With regards to atopic dermatitis, we noticed new studies on potential inducing factors (breastfeeding, probiotics, food, vitamins, prematurity, Staphylococcus aureus and constipation). There are also new data on therapy using tacrolimus. With regards to vascular anomalies and especially haemangiomas, the literature comprises new data on evolution and efficacy of propranolol. With regards to congenital nevi, there are studies related to treatment and complications. With regards to warts, the literature brings news about virus transmission and therapy. With regards to genodermatosi...

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[What's new in clinical dermatology?]

Annales de Dermatologie et de Cenereologie — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Morand JJ The actuality in clinical dermatology is, to our opinion, dominated by the emergent or reemergent infections (arboviruses, poxviruses, mycobacteria, leishmania, staphylococcus, papillomaviruses, bedbugs...) and their involvement in certain diseases (atopia, psoriasis), tumours or syndromes with dermatologic signs (IRIS). The cutaneous adverse side effects of the targeted chemotherapies and biotherapies are consequently better surrounded. Some rare new anatomoclinical entities are identified but <<classics>> (Lipschütz ulcer, pityriasis rosea, deep dissecting hematoma, puffy hand syndrome, disseminata alopecia areata) are rediscovered and better represented thanks to help, sometimes, by new techniques. PMID: 20110055 [PubMed - as supplied by publi...

Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusion Alefacept is ineffective for the treatment of severe AA. (Source: Archives of Dermatology)

Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study.

BMC Dermatology — Thu, 12 Nov 2009 00:00:00 +0100

Conclusions: Dermatologists' treatment of AA is inconsistent. A stronger evidence base will provide more consistent treatment options. (Source: BMC Dermatology)

Topical diphencyprone immunotherapy for cutaneous metastatic melanoma

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

Topical immunotherapy with contact sensitizers for metastatic melanoma was first reported more than 30 years ago. Diphencyprone (DPCP) immunotherapy is frequently used to treat cutaneous warts and alopecia areata, and we have previously reported the use of DPCP as a single agent to successfully treat extensive, radiotherapy-resistant melanoma metastases on the scalp. We now report DPCP treatment of a further six patients with cutaneous metastatic melanoma. Of seven patients treated with DPCP thus far, four have demonstrated complete responses of their cutaneous lesions and three have had partial responses. The treatment was well-tolerated by all patients. Topical immunotherapy with DPCP is inexpensive and relatively non-invasive and should be considered in patients with locally advanced sk...

Photodynamic therapy with methyl 5-aminolevulinate acid combined with microneedle treatment in patients with extensive alopecia areata

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

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Four Genes Linked to Alopecia Areata Discovered

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

New genetic research is yielding some important clues into the puzzling condition of alopecia areata, Dr. Maria Hordinsky reported at the women's and pediatric dermatology seminar sponsored by Skin Disease Education Foundation (SDEF). (Source: Skin and Allergy News)

Topical diphencyprone immunotherapy for cutaneous metastatic melanoma.

The Australasian Journal of Dermatology — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Damian DL, Shannon KF, Saw RP, Thompson JF Topical immunotherapy with contact sensitizers for metastatic melanoma was first reported more than 30 years ago. Diphencyprone (DPCP) immunotherapy is frequently used to treat cutaneous warts and alopecia areata, and we have previously reported the use of DPCP as a single agent to successfully treat extensive, radiotherapy-resistant melanoma metastases on the scalp. We now report DPCP treatment of a further six patients with cutaneous metastatic melanoma. Of seven patients treated with DPCP thus far, four have demonstrated complete responses of their cutaneous lesions and three have had partial responses. The treatment was well-tolerated by all patients. Topical immunotherapy with DPCP is inexpensive and relatively non-invasive and s...

Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions. Increased Th1 serum cytokines (IL-2, IL-12 and interferon-[gamma]) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy. (Source: Clinical And Experimental Dermatology)

Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopy

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions. Coudability hairs, more closely perceived by trichoscopy, are useful-markers for disease activity in AA and provide a surrogate-marker for the hair-pull test. (Source: Clinical And Experimental Dermatology)

STUDY: Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Archives of Dermatology — Mon, 19 Oct 2009 19:52:13 +0100

Conclusions Loose anagen hair syndrome is a common nonscarring alopecia in young girls with a history of sparse or fine hair. Before ordering extensive blood testing in young girls with diffusely thin hair, it is important to perform a hair-pull test, as a trichogram can be instrumental in the confirmation of a diagnosis of LAHS. (Source: Archives of Dermatology)

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Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome [Study]

Archives of Dermatology — Mon, 19 Oct 2009 19:52:13 +0100

Ocular Alterations In Patients of Alopecia Areata F1000 Ranking "Must Read" and "Changes Clinical Practice"

Medscape Ophthalmology Headlines — Tue, 06 Oct 2009 14:47:37 +0100

Corticosteroid patches for alopecia areata (AA) are significantly associated with cataracts and lens changes. All AA patients alopecia should have a rigorous ophthalmological examination before starting treatment. Faculty of 1000 Medicine (Source: Medscape Ophthalmology Headlines)

Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations

British Journal of Dermatology — Sun, 27 Sep 2009 23:00:00 +0100

We report a parent[ndash]child trio in which the mother and the son have PC and the father has IV. Both the mother and the son are carriers for the KRT16 mutation p.Leu132Pro. The son, who is much more severely affected than his mother, in addition carries the heterozygous FLG mutation p.R2447X, which was inherited from the father. This observation suggests that coinheritance of mutations in KRT16 and FLG may aggravate the PC phenotype and that FLG could serve as a genetic modifier in PC. (Source: British Journal of Dermatology)

’Beacon of hope’: Study finds melanocytes are target in alopecia areata

Modern Medicine — Mon, 14 Sep 2009 23:00:00 +0100

Portland, Ore. — A recent study confirms that the numbers of follicular melanocytes are significantly decreased in patients suffering from alopecia areata. This new insight into the often severe and psychologically burdensome disease serves as a beacon of hope for patients, as researchers begin to home in on a more precise etiology that may open the door for more targeted treatments. Past research has implicated follicular melanocytes to be the target structure in at least a proportion of patients suffering from alopecia areata. (Source: Modern Medicine)

Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids

Experimental Dermatology — Mon, 14 Sep 2009 23:00:00 +0100

In conclusion, increased serum sIL-2R level and lower IL-18 level at baseline was associated with a poor prognosis in patients with AA. (Source: Experimental Dermatology)

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Five-year experience in the treatment of alopecia areata with DPC

Journal of the European Academy of Dermatology and Venereology — Mon, 07 Sep 2009 23:00:00 +0100

Conclusion Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse. (Source: Journal of the European Academy of Dermatology and Venereology)

Etanercept: Alopecia areata: case report

Reactions — Mon, 31 Aug 2009 12:03:34 +0100

(Source: Reactions)

Melanocytes: A possible autoimmune target in alopecia areata

Journal of the American Academy of Dermatology — Wed, 26 Aug 2009 11:59:00 +0100

To the Editor: Alopecia areata (AA) is thought to be an autoimmune disease directed against the hair follicle that results in hair loss. Observationally, AA tends to respond to immunosuppressive therapy and occurs in patients with other autoimmune phenomena, such as autoimmune thyroiditis and vitiligo. Further support comes from animal models. In a severe combined immunodeficiency (SCID) mouse model (used because these mice will not reject human lymphocytes or skin), investigators have shown that as T lymphocytes disappear from engrafted AA-affected skin, hair growth ensues. Moreover, if T cells from AA patients are stimulated in vitro with hair follicle antigens and then injected into the engrafted skin on the immunodeficient mice, immunologic hair loss similar to that seen in AA ensues. ...

Instilled bimatoprost ophthalmic solution in patients with eyelash alopecia areata

Journal of the American Academy of Dermatology — Wed, 26 Aug 2009 11:59:00 +0100

The objective of our 16-week, open-label, prospective study was to assess the safety and efficacy of instilled bimatoprost ophthalmic solution in promoting eyelash growth in patients with AA. (Source: Journal of the American Academy of Dermatology)

Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata

Journal of the American Academy of Dermatology — Sun, 16 Aug 2009 23:00:00 +0100

Conclusion: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted. (Source: Journal of the American Academy of Dermatology)

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Diagnosing and treating hair loss.

American Family Physician — Fri, 14 Aug 2009 23:00:00 +0100

Authors: Mounsey AL, Reed SW Physicians should be careful not to underestimate the emotional impact of hair loss for some patients. Patients may present with focal patches of hair loss or more diffuse hair loss, which may include predominant hair thinning or increased hair shedding. Focal hair loss can be further broken down into scarring and nonscarring. Scarring alopecia is best evaluated by a dermatologist. The cause of focal hair loss may be diagnosed by the appearance of the patch and examination for fungal agents. A scalp biopsy may be necessary if the cause of hair loss is unclear. Alopecia areata presents with smooth hairless patches, which have a high spontaneous rate of resolution. Tinea capitis causes patches of alopecia that may be erythematous and scaly. Male and female pa...

History of atopy or autoimmunity increases alopecia risk

MedWire News - Respiratory — Mon, 03 Aug 2009 00:00:00 +0100

Individuals with a history of atopy or autoimmunity are at increased risk for developing alopecia areata, report investigators. (Source: MedWire News - Respiratory)

Female Adolescent Hair Disorders

Journal of Pediatric and Adolescent Gynecology — Fri, 31 Jul 2009 11:20:36 +0100

Abstract: Hair abnormalities can have tremendous psychosocial impacts on adolescents and young adults, and may cause a great amount of anxiety regarding physical appearance, associated illnesses, and potential clinical course. The pathophysiology of such disorders may vary, with potential congenital, infectious, autoimmune, nutritional, or environmental causes. Hair abnormalities may present as changes in hair appearance or quality, becoming weathered or fractured. An abnormal increase in hair is present in hypertrichosis and hirsutism, whereas a thinning or shedding of hair is evident in patients with telogen effluvium and alopecia areata. Diagnosis is focused on a detailed clinical history and physical exam, in addition to laboratory testing, a variety of clinical diagnostic tests, and s...

History of atopy or autoimmunity increases risk for alopecia areata

MedWire News - Dermatology — Fri, 24 Jul 2009 00:00:00 +0100

Individuals with a history of atopy or autoimmunity have increased risk for developing alopecia areata, report investigators. (Source: MedWire News - Dermatology)

History of atopy or autoimmunity increases risk of alopecia areata

Journal of the American Academy of Dermatology — Thu, 16 Jul 2009 23:00:00 +0100

Conclusion: This analysis revealed that a history of atopy and autoimmune disease was associated with an increased risk of AA and that the results were consistent for both the severe subtype of AA (ie, alopecia totalis and alopecia universalis) and the localized subtype (ie, AA persistent). (Source: Journal of the American Academy of Dermatology)

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Treatment of alopecia areata with fractional photothermolysis laser

International Journal of Dermatology — Mon, 13 Jul 2009 23:00:00 +0100

(Source: International Journal of Dermatology)

A study of stress management in patients stricken by alopecia areata

Psicologia em Estudo — Sun, 05 Jul 2009 11:26:35 +0100

Alopecia Areata é uma dermatose caracterizada pela perda repentina de pêlos em uma única ou em várias áreas, na forma de círculo. Normalmente a perda se inicia no couro cabeludo, podendo também ocorrer em outras partes do corpo. Fatores emocionais traumáticos são referidos como desencadeantes. Um grupo de 12 pacientes acometidos de alopecia areata foi avaliado por meio de entrevista psicológica e do método de Rorschach (Sistema Compreensivo por Exner), com vista a identificar as condições de personalidade dos pacientes no que se refere ao manejo do estresse. Todos os pacientes relataram episódios traumáticos em suas vidas que poderiam ser considerados como desencadeantes da doença, e nove apresentaram nítidas dificuldades no controle e manejo do estresse.Alopecia areata is...

Immune-mediated skin lesions in patients treated with anti-tumour necrosis factor alpha inhibitors.

Scandinavian Journal of Rheumatology — Fri, 03 Jul 2009 23:00:00 +0100

Conclusions: Our results on patients treated with TNF antagonists strongly support a link between TNF inhibition and IMSL development. Although these clinical complications are rare, clinicians should be aware of their occurrence and should recognize them. PMID: 19579151 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)

Treatment of alopecia areata in children.

Pediatric Annals — Tue, 30 Jun 2009 23:00:00 +0100

Authors: Mukherjee N, Burkhart CN, Morrell DS PMID: 19685659 [PubMed - in process] (Source: Pediatric Annals)

Hair diagnoses and signs: the use of dermatoscopy

Clinical And Experimental Dermatology — Sun, 21 Jun 2009 23:00:00 +0100

Conclusions. Dermatoscopy is most revealing in conditions resulting in gross changes in shaft outline and colour, where reflected light is valuable. It is unhelpful for detection of features within the shaft or at higher levels of resolution. When added to its ability to aid evaluation of scalp surface characteristics, dermatoscopy provides an excellent first-line method of assessment in clinics. In vivo it may aid screening and selection of hairs of greatest diagnostic yield for further assessment. In some instances, it may obviate the need for obtaining hair specimens and have implications for public health screening. Where detailed or cortical hair-shaft features need assessment, transmitted light microscopy remains the standard tool. (Source: Clinical And Experimental Dermatology)

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Adalimumab: Alopecia areata: case report

Reactions — Tue, 02 Jun 2009 22:36:40 +0100

(Source: Reactions)

Nails and hair

Medicine — Mon, 01 Jun 2009 04:00:00 +0100

Abstract: The hair and nail are appendages of the skin. They both hang off it and are part of it. Their growth, condition and integrity are indicators of both local and systemic pathologies. Age results in significant changes in hair growth with characteristic patterns of baldness evolving with time. Excess hair is largely a complaint of women where it may represent part of the normal spectrum of pigmented coarse hairs in a male distribution or be a sign of an endocrine pathology. The most common diseases causing disturbance of the nail are inflammatory diseases of the skin, such as psoriasis and eczema. These can also cause problems on the scalp, although the scarring skin diseases such as discoid lupus erythematosus and lichen planus are of additional significance at this site. Some infl...

The lived experience of alopecia areata: a qualitative study.

Body Image — Sun, 31 May 2009 23:00:00 +0100

This study explored experiences of individuals living with alopecia areata (AA) and alopecia universalis (AU) and investigated their accounts of adjusting to, and coping with, such conditions. Whilst previous research has primarily focused on the adverse psychosocial impact of alopecia, this investigation used Interpretive Phenomenological Analysis to provide a more holistic perspective. Biographical interviews were undertaken with 12 participants (7 women; 5 men) diagnosed with alopecia for periods ranging between 2 and 49 years. Results revealed that strategies used by participants evolved over time and that there were clear gender differences. In the early stages, participants did not want to contemplate that their hair loss would be lasting and managed the condition via concealment. La...

Adalimumab: Alopecia areata: case report.

Reactions Weekly — Sat, 30 May 2009 15:31:34 +0100

Page: 4 (Source: Reactions Weekly)

Prolactine levels in the patients with alopecia areata

Journal of the European Academy of Dermatology and Venereology — Wed, 06 May 2009 04:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

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[Update on the treatment of alopecia areata.]

Actas Dermo-Sifiliograficas — Thu, 30 Apr 2009 23:00:00 +0100

Authors: Galán-Gutiérrez M, Rodríguez-Bujaldón A, Moreno-Giménez JC Alopecia areata is nonscarring telogenic alopecia of autoimmune etiology. It is estimated to be the presenting complaint in 2 % of dermatologic consultations, and can appear at any age although it is more common in young patients. Treatment depends on several factors, such as extent of the disease and age, and may be local or systemic. Local treatments aim to achieve hair regrowth, but do not alter the underlying condition, whereas systemic treatments can modify the course of the disease. In neither case does treatment provide a cure. In this article, we review most of the therapeutic options described in the literature for alopecia areata. PMID: 19463229 [PubMed - in process] (Source: Acta...

Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases

The Journal of Dermatology — Tue, 28 Apr 2009 04:00:00 +0100

To study the effect of fexofenadine on extensive alopecia areata (AA), we evaluated retrospectively 121 patients with AA having alopecia in more than 50% of the scalp and followed them for at least 6 months. Patients were treated by immunotherapy using diphenylcyclopropenone or squaric acid dibutylester with or without oral fexofenadine. The regrowth score was estimated as decrease of Severity of Alopecia Tool (SALT) score. In AA with atopic background (atopic AA), the mean regrowth score of the fexofenadine group was 1.333 (n = 33) and that of the control 0.471 (n = 34). The fexofenadine group showed significantly better regrowth than control by Mann[ndash]Whitney's U-test (P = 0.00213). In non-atopic AA, the mean regrowth score of the fexofenadine group was 1.303 (n = 33) and that of the...

Psoriasiform eruption associated with alopecia areata during infliximab therapy

Clinical And Experimental Dermatology — Sun, 26 Apr 2009 23:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Traumatic Events in the Past May Increase Vulnerability to Alopecia Areata

Medscape Dermatology Headlines — Mon, 13 Apr 2009 16:23:58 +0100

Adults with alopecia areata are significantly more likely to have a history of childhood and lifetime traumatic events than adults without this hair condition, which is thought to be an autoimmune disorder, according to results of a case-control study conducted in Belgium. Reuters Health Information (Source: Medscape Dermatology Headlines)

Alopecia areata is not associated with Helicobacter pylori

Indian Journal of Dermatology — Tue, 07 Apr 2009 11:50:05 +0100

Conclusions: The results have shown that a relation between Helicobacter pylori and alopecia areata is not supported. We advise that H. pylori detection need not to be included in the laboratory work up of alopecia areata. (Source: Indian Journal of Dermatology)

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The efficacy of topical diphencyprone in the treatment of alopecia areata

Indian Journal of Dermatology — Tue, 07 Apr 2009 11:50:05 +0100

Maryam Akhyani, Hassan Seirafi, Farshad Farnaghi, Parastoo Banan, Vahide LajevardiIndian Journal of Dermatology 2009 54(1):88-89 (Source: Indian Journal of Dermatology)

Non-infectious inflammatory disorders of the nail apparatus

JDDG — Mon, 06 Apr 2009 04:00:00 +0100

Inflammatory non-infectious diseases of the nails are not uncommon. The nail changes may look different in the same diseases, but also very much alike in various different nail disorders depending on which particular structure of the nail apparatus is involved. Of all skin diseases, psoriasis is the one with the most frequent nail involvement. The presence of many pits allows the diagnosis to be made, but salmon spots and onycholysis are also characteristic features. Lichen planus may occur isolated on the nails or in association with lesions of the skin and adjacent mucosal membranes. Longitudinal striations and loss of the nail plate shine are the most frequent features of nail lichen planus. The more severe the alopecia areata is and the younger the patient is, the more often it affects...

Alexithymia in patients with alopecia areata: educational background much more important than traumatic events

Journal of the European Academy of Dermatology and Venereology — Thu, 02 Apr 2009 04:00:00 +0100

Conclusion In adult AA patients, higher levels of education are significantly associated with lower alexithymia scores. Somewhat unexpectedly, we found no association between alexithymia score and emotional neglect or childhood traumatic experiences. Our results also confirm that alexithymia scores are significantly higher in adult patient with AA compared with control patients. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

Lack of efficacy of topical latanoprost and bimatoprost ophthalmic solutions in promoting eyelash growth in patients with alopecia areata.

Journal of the American Academy of Dermatology — Fri, 20 Mar 2009 14:41:05 +0100

Authors: Roseborough I, Lee H, Chwalek J, Stamper RL, Price VH PMID: 19293023 [PubMed - in process] (Source: Journal of the American Academy of Dermatology)

Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata

Archives of Dermatological Research — Fri, 20 Mar 2009 10:41:20 +0100

Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients h...

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Adalimumab: Alopecia areata: case report

Reactions — Tue, 17 Mar 2009 08:38:10 +0100

(Source: Reactions)

Adalimumab: Alopecia areata: case report.

Reactions Weekly — Sun, 15 Mar 2009 03:38:56 +0100

Page: 5 (Source: Reactions Weekly)

Capsaicin vs. clobetasol for the treatment of localized alopecia areata

Journal of the European Academy of Dermatology and Venereology — Thu, 05 Mar 2009 05:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Is Helicobacter pylori infection associated with alopecia areata?

Journal of Cosmetic Dermatology — Tue, 17 Feb 2009 05:00:00 +0100

Conclusions Based on these results, the relation between H. pylori and AA is not supported. We advise that H. pylori detection should not be included in the laboratory workup of AA. (Source: Journal of Cosmetic Dermatology)

Scalp dermoscopy of androgenetic alopecia in Asian people.

The Journal of Dermatology — Sun, 01 Feb 2009 05:00:00 +0100

In conclusion, dermoscopy is useful to diagnose AGA and FAGA and provides insights into the pathogenesis of AGA. PMID: 19284450 [PubMed - in process] (Source: The Journal of Dermatology)

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Trace element levels in alopecia areata

Indian Journal of Dermatology, Venereology and Leprology — Sun, 25 Jan 2009 03:52:23 +0100

Conclusion: We conclude that copper and magnesium levels are not altered in AA, but the decreased zinc levels found in our study may merit further investigation of the relationship. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Investigation of the Inflammatory Mechanisms in Alopecia Areata.

The American Journal of Dermatopathology — Thu, 22 Jan 2009 07:31:09 +0100

Page: 53DOI: 10.1097/DAD.0b013e318185a66eAuthors: Cetin, Emel Dikicioglu MD *; Savk, Ekin MD +; Uslu, Meltem MD +; Eskin, Mehmet PhD ++; Karul, Aslhan MD [S][latin dotless i] (Source: The American Journal of Dermatopathology)

Trace element levels in alopecia areata

Indian Journal of Dermatology, Venereology and Leprology — Thu, 22 Jan 2009 04:17:30 +0100

An uncontrolled, open label study of sulfasalazine in severe alopecia areata

Indian Journal of Dermatology, Venereology and Leprology — Fri, 16 Jan 2009 04:12:33 +0100

Conclusion: Sulfasalazine could be considered as a therapeutic alternative in the treatment of AA, because of its safety profile, cosmetically acceptable efficacy, and good tolerability. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Choosing topical corticosteroids.

American Family Physician — Thu, 15 Jan 2009 05:00:00 +0100

Authors: Ference JD, Last AR Topical corticosteroids are one of the oldest and most useful treatments for dermatologic conditions. There are many topical steroids available, and they differ in potency and formulation. Successful treatment depends on an accurate diagnosis and consideration of the steroid's delivery vehicle, potency, frequency of application, duration of treatment, and side effects. Although use of topical steroids is common, evidence of effectiveness exists only for select conditions, such as psoriasis, vitiligo, eczema, atopic dermatitis, phimosis, acute radiation dermatitis, and lichen sclerosus. Evidence is limited for use in melasma, chronic idiopathic urticaria, and alopecia areata. PMID: 19178066 [PubMed - in process] (Source: American Family Physician)

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Bald Is Beautiful?: The Psychosocial Impact of Alopecia Areata

Journal of Health Psychology — Wed, 07 Jan 2009 05:00:00 +0100

This study reviewed previous studies to explore the psychosocial impact of having alopecia areata (AA). Nineteen primary studies, representing a total of 1271 participants from nine different countries are described and the psychosocial impact of AA is considered. Upon review of the evidence, it is apparent that AA causes dramatic and devastating emotions in patients, which can negatively impact their self-esteem, body image, and/or self-confidence. The negative impact of AA may be heightened for female patients due to the societal pressure to be attractive. Treatment for alopecia patients should offer psychological support to foster increased self-esteem and adaptation to their disorder. (Source: Journal of Health Psychology)

Alopecia areata incognita: True or false?

Journal of the American Academy of Dermatology — Wed, 24 Dec 2008 20:13:26 +0100

Authors: Rakowska A, Slowinska M, Kowalska-Oledzka E, Olszewska M, Czuwara J, Rudnicka L PMID: 19103371 [PubMed - in process] (Source: Journal of the American Academy of Dermatology)

Adalimumab: Alopecia areata universalis: case report.

Reactions Weekly — Sun, 07 Dec 2008 08:49:36 +0100

Page: 4 (Source: Reactions Weekly)

Adalimumab: Alopecia areata universalis: case report

Reactions — Sun, 07 Dec 2008 08:20:55 +0100

(Source: Reactions)

Acute diffuse and total alopecia: A new subtype of alopecia areata with a favorable prognosis.

Journal of the American Academy of Dermatology — Wed, 05 Nov 2008 05:00:00 +0100

CONCLUSIONS: These cases can be categorized as having "acute diffuse and total alopecia," a new subtype of AA that is associated with a favorable prognosis and rapid and spontaneous recovery even without treatment. PMID: 18992964 [PubMed - as supplied by publisher] (Source: Journal of the American Academy of Dermatology)

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The α-melanocyte stimulating hormone-related tripeptide K(D)PT stimulates human hair follicle pigmentation in situ under proinflammatory conditions

British Journal of Dermatology — Tue, 28 Oct 2008 04:00:00 +0100

Conclusions The IL-1[beta]- and [alpha]-MSH-related tripeptide, K(D)PT, displays interesting hair pigmentation-stimulatory activities under proinflammatory conditions. These might become exploitable for innovative antigreying strategies, notably in postinflammatory poliosis (regrowth of white hair, e.g. during recovery from alopecia areata), where no effective clinical therapy is yet available. (Source: British Journal of Dermatology)

Phototherapy in Childhood

Pediatric Dermatology — Fri, 24 Oct 2008 04:00:00 +0100

Conclusion: Phototherapy is a well-tolerated treatment for childhood dermatoses, and is especially efficacious in psoriasis and pityriasis lichenoides chronica patients. (Source: Pediatric Dermatology)

Alopecia Areata Universalis during Treatment of Rheumatoid Arthritis with Anti-TNF-a Antibody (Adalimumab)

Dermatology — Tue, 14 Oct 2008 10:43:51 +0100

Dermatology 2008;217:380 (DOI:10.1159/000162180) (Source: Dermatology)

The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients

Archives of Dermatological Research — Wed, 08 Oct 2008 09:50:19 +0100

Abstract Vitiligo is a common skin and hair depigmentary disorder that results from selective destruction of melanocytes. It occurs in a typical multifactorial, polygenic inheritance. Several studies have indicated that vitiligo is associated with some autoimmune diseases. In this paper we examined 6,516 vitiligo patients including clinical characteristics, familial involvement, and their association with other autoimmune diseases. Compared with sporadic vitiligo probands, familial vitiligo probands have earlier age onset and longer disease duration. The prevalences of four autoimmune diseases namely rheumatoid arthritis, chronic urticaria, alopecia areata and psoriasis, were significantly elevated in generalized vitiligo probands and their first-degree relatives. The prev...

Cicatricial marginal alopecia: is it all traction?

The British Journal of Dermatology — Mon, 22 Sep 2008 04:00:00 +0100

Conclusions A group of patients with moderate to severe cicatricial alopecia of the scalp margin is described. The presence of scarring is difficult to diagnose both clinically and histologically. The lack of a history of severe traction or harsh styling practices in half the patients casts doubt on whether or not traction is the only pathogenic factor. PMID: 18811691 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Topical dinitrochlorobenzene (DNCB) for alopecia areata: Revisited

Indian Journal of Dermatology, Venereology and Leprology — Fri, 19 Sep 2008 07:41:45 +0100

Mohan K H, Balachandran C, Shenoi S D, Rao Raghavendra, Sripathi H, Prabhu SmithaIndian Journal of Dermatology, Venereology and Leprology 2008 74(4):401-402 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Immunopathogenesis of folliculitis decalvans: clues in early lesions.

American Journal of Clinical Pathology — Wed, 17 Sep 2008 16:09:44 +0100

Authors: Chiarini C, Torchia D, Bianchi B, Volpi W, Caproni M, Fabbri P Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD.Lesional scalp biopsy specimens from 7 patients with FD, 7 with lichen planopilaris, and 4 with alopecia areata were studied immunohistochemically by using monoclonal antibodies to CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon gamma, tumor necrosis factor alpha, basic fibroblast growth factor (b-FGF), transforming growth factor (TGF)-beta, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule (ICAM)-1, and v...

Successful Hair Transplantation of Recalcitrant Alopecia Areata of the Scalp

Dermatologic Surgery — Tue, 16 Sep 2008 04:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Topical dinitrochlorobenzene (DNCB) for alopecia areata: Revisited

Indian Journal of Dermatology, Venereology and Leprology — Sat, 13 Sep 2008 07:34:50 +0100

K H Mohan, C Balachandran, S D Shenoi, Raghavendra Rao, H Sripathi, Smitha PrabhuIndian Journal of Dermatology, Venereology and Leprology 2008 74(4):401-402 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Clinical: Alopecia - Contributed by Dr Jean Watkins, a sessional GP in Hampshire

HealthcareRepublic GP News — Fri, 12 Sep 2008 00:00:00 +0100

Alopecia areata (Source: HealthcareRepublic GP News)

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A combination of ciclosporin and methylprednisolone may be useful for the treatment of severe alopecia areata

Inpharma — Mon, 01 Sep 2008 06:49:13 +0100

(Source: Inpharma)

A combination of ciclosporin and methylprednisolone may be useful for the treatment of severe alopecia areata,.

Inpharma Weekly — Sat, 30 Aug 2008 09:27:57 +0100

Page: 13 (Source: Inpharma Weekly)

Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives.

Journal of Autoimmunity — Thu, 07 Aug 2008 04:00:00 +0100

Authors: Neuhausen SL, Steele L, Ryan S, Mousavi M, Pinto M, Osann KE, Flodman P, Zone JJ The occurrence of other autoimmune diseases in celiac disease families has not been previously reported in a North American population. We investigated the familial aggregation of rheumatoid arthritis (RA), juvenile rheumatoid arthritis/juvenile idiopathic arthritis (JRA/JIA), hypothyroidism, insulin dependent diabetes mellitus (IDDM), and alopecia areata (AA) among individuals in families with celiac disease (CD). Family history information, obtained from questionnaires from the University of California Irvine Celiac Disease study, was reviewed for reports of RA, JRA/JIA, hypothyroidism, IDDM, and AA in celiac disease cases and their first-degree relatives. Reports of disease were compared with p...

Sulfasalazine an option for recalcitrant alopecia areata

MedWire News - Dermatology — Sat, 02 Aug 2008 16:22:25 +0100

Sulfasalazine can be used as an alternative treatment for alopecia areata in patients who do not respond to standard therapies, study findings suggest. (Source: MedWire News - Dermatology)

Evaluation of serum iron and ferritin levels in alopecia areata.

Dermatol Online J — Fri, 18 Jul 2008 07:28:48 +0100

Authors: Esfandiarpour I, Farajzadeh S, Abbaszadeh M Although immunologic processes and hereditary factors are suggested to play an important role in alopecia areata, the specific etiology is unclear. Iron deficiency has been suggested to play a role, but its effect is controversial. In our case control study, we found a higher mean level of serum iron and ferritin and a lower mean level of TIBC in patients compared to control subjects, but the differences did not reach significance. PMID: 18627722 [PubMed - in process] (Source: Dermatol Online J)

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Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis

Journal of Diabetes and Its Complications — Wed, 09 Jul 2008 00:00:00 +0100

Abstract: A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious...

Alopecia areata and autoimmunity: A clinical study

Indian Journal of Dermatology — Fri, 04 Jul 2008 07:55:48 +0100

Thomas Emy Abi, Kadyan RSIndian Journal of Dermatology 2008 53(2):70-74 (Source: Indian Journal of Dermatology)

The autoimmune regulator gene (AIRE) is strongly associated with vitiligo

British Journal of Dermatology — Fri, 04 Jul 2008 04:00:00 +0100

Conclusions The link between vitiligo and AIRE raises the possibility that defective skin peripheral antigen selection in the thymus is involved in the changes that result in melanocyte destruction in this disorder. (Source: British Journal of Dermatology)

Videodermoscopy may help avoid unnecessary biopsies in alopecia areata incognita

MedWire News - Dermatology — Fri, 04 Jul 2008 00:00:00 +0100

Videodermoscopy can help clinicians find the right place to take a biopsy, but can also avoid unnecessary biopsies in alopecia areata incognita, say researchers. (Source: MedWire News - Dermatology)

The role of scalp dermoscopy in the diagnosis of alopecia areata incognita.

Journal of the American Academy of Dermatology — Tue, 01 Jul 2008 04:00:00 +0100

CONCLUSION: Videodermoscopy is a first step before performing a biopsy. It can help the clinician to find the right place to take the sample, but can also avoid unnecessary biopsies. PMID: 18440667 [PubMed - indexed for MEDLINE] (Source: Journal of the American Academy of Dermatology)

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The autoimmune regulator gene (AIRE) is strongly associated with vitiligo.

The British Journal of Dermatology — Tue, 01 Jul 2008 04:00:00 +0100

Prevalence of skin diseases among pediatric patients in Turkey.

The Journal of Dermatology — Tue, 01 Jul 2008 04:00:00 +0100

Authors: Tamer E, Ilhan MN, Polat M, Lenk N, Alli N The pediatric population is composed of persons under 16 years of age, and few studies are available on the dermatological diseases of this group. In the present study, data on a total of 6300 pediatric patients admitted between the years 2004-2006 were analyzed. Hospital-based patient registry records were used for data collection. The data were analyzed according to age, sex and time of admittance. A female preponderance (53%) was observed, and adolescents (12-16 years old) constituted the largest group within the patient population (47.6%). A total of 125 dermatoses were recorded. Acne vulgaris was the most prevalent dermatosis (12.4%), followed by atopic dermatitis (11.8%), contact dermatitis (11.3%), warts (9.5%), seborrheic derm...

Clinical significance of dermoscopy in alopecia areata: analysis of 300 cases

International Journal of Dermatology — Fri, 20 Jun 2008 15:32:41 +0100

International Journal of Dermatology, Volume 47, Issue 7, Page 688-693, July 2008. Abstract Objective To determine dermoscopic findings of alopecia areata (AA) from a large-scale study that can be used as clinical indicators of disease. Methods Dermoscopic examination of areas of hair loss on the scalp of 300 Asian patients with AA ... (Source: International Journal of Dermatology)

Follicular streamers (stelae) in scarring and non-scarring alopecia.

Journal of Cutaneous Pathology — Thu, 19 Jun 2008 04:00:00 +0100

Conclusions: Follicular streamers are found predominantly in non-scarring alopecia cases. Streamers found at deep dermal or subcutaneous levels should be followed and identified at the FU level in order to obtain accurate follicular counts and follicular ratios needed for non-scarring alopecia diagnosis. PMID: 18616766 [PubMed - as supplied by publisher] (Source: Journal of Cutaneous Pathology)

Vitamin D-Dependent Rickets Type II: Report of a Novel Mutation in the Vitamin D Receptor Gene.

Archives of Iranian Medicine — Thu, 01 May 2008 04:00:00 +0100

In this report, we present the clinical findings on a family which exhibited the typical clinical features of hereditary vitamin D-resistant rickets in two siblings. In addition, molecular analysis of the vitamin D receptor gene was performed by sequencing all coding exons. The cardinal findings in the index patient were alopecia totalis, renal tubular acidosis, mild generalized aminoaciduria, refractory rickets, high alkaline phosphatase, and hyperparathyroidism. Other routine biochemical tests were within normal limits, but 1+ glycine was detected in his urine. Skin biopsy results were compatible with alopecia areata. A previous child with similar phenotype was reported to be deceased at the age of 32 months. Mutation analysis of the vitamin D receptor gene by direct sequencing analysis ...

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Familial alopecia areata and chronic thrombocytopenia.

Journal of the American Academy of Dermatology — Thu, 01 May 2008 04:00:00 +0100

We report a family in which multiple members are affected with AA and with a hereditary thrombocytopenia, most consistent with pseudo-von Willebrand disease. This raises the possibility of a genetic association between AA and one or more of the inherited thrombocytopenias, possibly both related to mutations in genes on chromosome 17. PMID: 18489053 [PubMed - in process] (Source: Journal of the American Academy of Dermatology)

Pulstherapie mit hochdosierten intravenösen Kortikosteroiden bei Alopecia areata: Eigene Erfahrungen im Vergleich zur Literatur

JDDG — Fri, 25 Apr 2008 08:43:29 +0100

JDDG, Volume 6, Issue 5, Page -, May 2008. (Source: JDDG)

Cochrane review: Interventions for alopecia areata

NeLM Headline News — Tue, 22 Apr 2008 00:00:00 +0100

According to the findings of a systematic review conducted by the Cochrane Collaboration, few treatments for alopecia areata (AA) have been well evaluated in randomised, controlled trials. AA is a disorder where there is a loss of hair with no scarring to the affected area. It can affect the entire scalp (alopecia totalis) or cause loss of all body hair (alopecia universalis). Its cause is not yet fully understood, and although it can start at any age, it will most commonly develop before 20 years of age. Although in many cases it can be a self-limiting condition, the hair loss will often have a severe social and emotional impact. Current treatments used for AA include corticosteroids (topical, local injection, oral, injection); systemic immunosuppression (e.g. psoralens plus PUVA); ora...

Onion juice may help patchy hair loss

United Press International - Health Business — Wed, 16 Apr 2008 15:09:37 +0100

Onion juice could help some people with patchy hair loss resulting from the disease alopecia areata, an Australian researcher says. (Source: United Press International - Health Business)

Common Treatments For Patchy Hair Loss Not Supported By Studies

Immune System / Vaccines News From Medical News Today — Wed, 16 Apr 2008 12:00:00 +0100

If clumps of your hair start to fall out from a common form of baldness, a new review of existing research unfortunately offers little comfort.Patients who are afflicted by the condition known as alopecia areata - patchy hair loss - should understand that there is "no reliable, safe, effective, long-term treatment," said review co-author Dr. Mike Sladden, a dermatologist and senior lecturer at the University of Tasmania in Australia. (Source: Immune System / Vaccines News From Medical News Today)

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Studies Don't Support Common Treatments For Patchy Hair Loss

ScienceDaily Headlines — Wed, 16 Apr 2008 06:35:25 +0100

If clumps of your hair start to fall out from a common form of baldness, a new review of existing research unfortunately offers little comfort. Patients who are afflicted by the condition known as alopecia areata -- patchy hair loss -- should understand that there is no reliable, safe, effective, long-term treatment. (Source: ScienceDaily Headlines)

Alopecia areata progressing to totalis/universalis in non-insulin dependent diabetes mellitus (type II): Failure of dexamethasone-cyclophosphamide pulse therapy

Indian Journal of Dermatology, Venereology and Leprology — Wed, 02 Apr 2008 09:56:40 +0100

Sehgal Virendra N, Bhattacharya Sambit N, Sharma Sonal, Srivastava Govind, Aggarwal Ashok KIndian Journal of Dermatology, Venereology and Leprology 2008 74(2):171-173 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Primary Cutaneous Follicle Center Lymphoma Associated with Alopecia Areata.

Clinical Lymphoma and Myeloma — Tue, 01 Apr 2008 04:00:00 +0100

We report a patient who presented simultaneously with primary cutaneous follicle center lymphoma (PCFCL) of the face and scalp and alopecia areata of the scalp and beard bearing a clonal T-cell receptor gene rearrangement. To our knowledge, alopecia areata has not been previously reported in association with PCFCL. Both lesions regressed with topical imiquimod and systemic steroids, which suggests an inter-relationship in this case between the clonal B-cell and T-cell populations in driving outgrowth of these lesions. PMID: 18501107 [PubMed - as supplied by publisher] (Source: Clinical Lymphoma and Myeloma)

Infliximab: Worsening alopecia areata and halo naevi: case report

Reactions — Mon, 17 Mar 2008 07:59:47 +0100

(Source: Reactions)

Infliximab: Worsening alopecia areata and halo naevi: case report.

Reactions Weekly — Sat, 15 Mar 2008 07:31:33 +0100

Page: 17 (Source: Reactions Weekly)

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Discoid lupus erythematosus exacerbated by contact dermatitis caused by use of squaric acid dibutylester for topical immunotherapy in a patient with alopecia areata

The Journal of Dermatology — Fri, 14 Mar 2008 04:17:04 +0100

The Journal of Dermatology, Volume 35, Issue 3, Page 151-153, March 2008. ABSTRACT A 57-year-old Japanese male patient with an 18-year history of discoid lupus erythematosus (DLE) presented with alopecia on his scalp, and was clinically diagnosed to have alopecia areata. He was started on topical immunotherapy with squaric ... (Source: The Journal of Dermatology)

Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy

British Journal of Dermatology — Sat, 16 Feb 2008 07:55:38 +0100

British Journal of Dermatology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: British Journal of Dermatology)

Allergic contact dermatitis from 2-ethylhexyl acrylate contained in a wig-fixing adhesive tape and its ‘incidental’ therapeutic effect on alopecia areata

Contact Dermatitis — Wed, 13 Feb 2008 06:50:05 +0100

Contact Dermatitis, Volume 58, Issue 3, Page 170-171, March 2008. (Source: Contact Dermatitis)

Bexarotene, an antineoplastic agent, showed activity in the treatment of alopecia areata

Inpharma — Sun, 10 Feb 2008 07:50:40 +0100

(Source: Inpharma)

Bexarotene, an antineoplastic agent, showed activity in the treatment of alopecia areata,.

Inpharma Weekly — Sat, 09 Feb 2008 08:39:51 +0100

Page: 6 (Source: Inpharma Weekly)

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Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model.

Am J Pathol — Sat, 02 Feb 2008 05:00:00 +0100

Authors: Nakamura M, Jo JI, Tabata Y, Ishikawa O Autoimmune alopecia (alopecia areata) is considered to be triggered by a collapse of immune privilege in hair follicles. Here we confirmed that infiltrating CD4 T lymphocytes around hair follicles of patients with alopecia areata were primarily CCR5-positive with few CCR4-positive cells, suggesting a dominant role of Th1 cells in the alopecic lesion. Given this finding, we sought to elucidate the effect of cytokine therapy in C3H/HeJ mice, a mouse model of alopecia areata, by applying recombinant interleukin-4 and neutralizing anti-interferon-gamma antibody. We found that local injections of both interleukin-4 and neutralizing anti-interferon-gamma antibody effectively treated alopecia in C3H/HeJ mice. Results from immunohistochemistry a...

Worsening Alopecia Areata and de novo Occurrence of Multiple Halo Nevi in a Patient Receiving Infliximab

Karger Publishers — Thu, 24 Jan 2008 10:22:34 +0100

Dermatology 2008;216:185-186 (DOI:10.1159/000111523) (Source: Karger Publishers)

High-dose intravenous corticosteroid pulse therapy in alopecia areata: Own experience compared with the literature

JDDG — Thu, 17 Jan 2008 15:04:56 +0100

JDDG, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary Background: Seven prospective studies including 193 patients have been published on high-dose intravenous corticosteroid pulse therapy in alopecia areata (AA).We compare these data with a retrospective analysis of our own consecutive patients. ... (Source: JDDG)

Dermal mucin in alopecia areata – tell tale sign or incidental finding?

Journal of Cutaneous Pathology — Tue, 15 Jan 2008 03:25:57 +0100

We report a 27-year-old African-American female with systemic lupus erythematosus and alopecia areata, whose ... (Source: Journal of Cutaneous Pathology)

Genetic analysis of autoimmune regulator haplotypes in alopecia areata

Tissue Antigens — Fri, 11 Jan 2008 01:13:13 +0100

Tissue Antigens, Volume 0, Issue 0, Page ???, April 2004. AbstractAlopecia areata is an immune-mediated disorder, occurring with the highest observed frequency in the rare recessive autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) syndrome caused by mutations of the autoimmune regulator (... (Source: Tissue Antigens)

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Prevalence of Skin Diseases Among Schoolchildren in Magong, Penghu, Taiwan: A Community-based Clinical Survey.

J Formos Med Assoc — Tue, 01 Jan 2008 05:00:00 +0100

Conclusion: Compared with our previous study in Kaohsiung County using similar methodology, the point prevalence of atopic dermatitis and ephelides was significantly higher whereas that of fungal infection was lower in Penghu. Unexpectedly, tinea nigra was not rare in Penghu. PMID: 18218574 [PubMed - in process] (Source: J Formos Med Assoc)

Tacrolimus in dermatology-pharmacokinetics, mechanism of action, drug interactions, dosages, and side effects: part I.

Skinmed — Tue, 01 Jan 2008 05:00:00 +0100

Authors: Sehgal VN, Srivastava G, Dogra S The advent of tacrolimus at the end of the preceding century in the armamentarium of atopic dermatitis management was hailed as a breakthrough advance. It was, therefore, thought worthwhile to precisely review its origin and mechanism of action. Its topical application in the form of 0.03% to 0.1% ointments is rapidly effective and safe in pediatric and adult patients. Its use in atopic dermatitis ever since has been approved in Japan, the United States, Europe, and the Indian subcontinent. Thus, its local immunosuppressive action was fairly intriguing. Accordingly, its indications/uses were extended to cover several inflammatory dermatoses. Vitiligo, psoriasis, alopecia areata, contact hypersensitivity, lichen planus, pyoderma gangrenosum, ich...

The effect of methylprednisolone pulse-therapy plus oral cyclosporine in the treatment of alopecia totalis and universalis.

Archives of Iranian Medicine — Tue, 01 Jan 2008 05:00:00 +0100

The objective of this study was to evaluate the therapeutic and side effects of pulse-therapy with methylprednisolone combined with oral cyclosporine in severe alopecia areata, defined as alopecia totalis and universalis. Six patients with alopecia totalis and 12 patients with alopecia universalis were referred to our center. The patients were treated with monthly intravenous methylprednisolone in doses of 500 mg for three days and oral cyclosporine (2.5 mg/kg/day) for five to eight months. Responses were categorized as: "adequate" (i.e., hair regrowth on > or =70% of the affected area) and "inadequate" (i.e., hair regrowth on <70% of the affected area). Adequate response was observed in six (33%) patients: three with alopecia totalis and 3 with alopecia universalis. Responses were b...

Two cases of alopecia areata responsive to fexofenadine

The Journal of Dermatology — Sat, 08 Dec 2007 02:04:37 +0100

The Journal of Dermatology, Volume 34, Issue 12, Page 852-854, December 2007. (Source: The Journal of Dermatology)

Link between tooth infection and hair loss

News-Medical News Feed — Wed, 28 Nov 2007 22:00:00 +0100

There is a close relationship between infection outbreaks on teeth and the presence of alopecia areata or localized alopecia, a type of hair loss which has an unknown origin. (Source: News-Medical News Feed)

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Infection Outbreaks On Teeth Can Cause 'Alopecia Areata' Or Localized Hair Loss

Dermatology News From Medical News Today — Wed, 28 Nov 2007 16:00:00 +0100

There is a close relationship between infection outbreaks on teeth and the presence of alopecia areata or localized alopecia, a type of hair loss which has an unknown origin. Alopecia areata starts with bald patches on the scalp, and sometimes elsewhere on the body. The disease occurs in males and females of all ages, and experts believe that it affects 1 out 1000 people. [click link for full article] (Source: Dermatology News From Medical News Today)

Infection outbreaks on teeth can cause 'alopecia areata' or localized hair loss

EurekAlert! - Medicine and Health — Tue, 27 Nov 2007 05:00:00 +0100

Alopecia areata occurs in males and females of all ages. It starts with patches on the scalp, and sometimes elsewhere on the body. Researchers of the University of Granada advise to going to the dentist when patients notice localized hair loss in order to have their oral health carefully examined. (Source: EurekAlert! - Medicine and Health)

The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata

British Journal of Dermatology — Mon, 19 Nov 2007 21:15:34 +0100

British Journal of Dermatology, Volume 0, Issue 0, Page ???, -Not available-. SummaryBackground The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe ... (Source: British Journal of Dermatology)

Zonisamide: Alopecia areata: 2 case reports

Reactions — Sun, 18 Nov 2007 13:38:42 +0100

(Source: Reactions)

Zonisamide: Alopecia areata: 2 case reports.

Reactions Weekly — Sat, 17 Nov 2007 01:29:23 +0100

Page: 35 (Source: Reactions Weekly)

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A Practical Guide to the E-Mail Interview

Qualitative Health Research — Tue, 13 Nov 2007 05:00:00 +0100

The e-mail interview is a novel technique that has a number of advantages over traditional interviewing, but there are also some disadvantages. In this methodological article, the authors review the issues surrounding the use of the e-mail interview, providing a concrete example of its use, that of interviewing people with alopecia areata regarding psychological issues associated with the disorder. The authors show in the article that the e-mail interview is an effective interview technique but that users must take account of a number of sensitive issues, and there are a number of serious disadvantages that limit its use to specific areas. The e-mail interview cannot be used simply as a cheap alternative to face-to-face interviews in all circumstances. (Source: Qualitative Health Research)

A case of widespread non-pigmented hair regrowth in diffuse alopecia areata.

The Australasian Journal of Dermatology — Thu, 01 Nov 2007 04:00:00 +0100

Authors: Dinh QQ, Chong AH A 62-year-old woman presented with diffuse alopecia areata affecting more than 50% of her scalp hairs with sparing of non-pigmented hairs. She was treated with a 2-month course of oral prednisolone and extensive hair regrowth occurred. The new hairs were completely non-pigmented. As a result, the patient's hair colour is now strikingly and completely white, with a normal hair density. This response has been sustained for 6 months after cessation of treatment. PMID: 17956479 [PubMed - indexed for MEDLINE] (Source: The Australasian Journal of Dermatology)

Alopecia areata universalis in an infant

Tue, 30 Oct 2007 14:45:23 +0100

Conclusions Alopecia areata should be included in the differential diagnosis of generalized alopecia presenting at or shortly after birth. For purposes of genetic counseling and prognosis, it is crucial that a correct diagnosis be made. Content Type Journal ArticleCategory Case ReportsDOI 10.1007/BF02737867Authors Jo Anne LaRow, Albany Medical College A-81 Division of Dermatology and Dermatopathology 12208 Albany NY USAJudith Mysliborski, Capital District Dermatology 12208 Albany New YorkI. Paul Rappaport, Aesthetic Laser & Skin Care Center 12866 Saratoga Springs New YorkGuy A. Rouleau, Montreal General Hospital Centre for Research in Neurosciences H3G 1A4 Montréal CanadaJ. Andrew Carlson, Albany Medical College A-81 Division of Dermatology and Dermatopathology 12208 ...

A case of widespread non-pigmented hair regrowth in diffuse alopecia areata

Australasian Journal of Dermatology — Fri, 19 Oct 2007 05:36:51 +0100

Australasian Journal of Dermatology, Volume 48, Issue 4, Page 221-223, November 2007. SUMMARY A 62-year-old woman presented with diffuse alopecia areata affecting more than 50% of her scalp hairs with sparing of non-pigmented hairs. She was treated with a 2-month course of oral prednisolone and extensive hair regrowth occurred. The new ... (Source: Australasian Journal of Dermatology)

Pictorial case study: alopecia areata

HealthcareRepublic Registrar Education Articles — Fri, 21 Sep 2007 00:00:00 +0100

(Source: HealthcareRepublic Registrar Education Articles)

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308-nm Excimer Laser for the Treatment of Alopecia Areata

Dermatologic Surgery — Mon, 10 Sep 2007 21:23:23 +0100

Dermatologic Surgery Volume 0, Issue 0, Page ???-???. BACKGROUND Alopecia areata is loss of hair from localized or diffuse areas of hair-bearing area of the skin. Recently there are reports of efficacy of the 308-nm excimer radiation for this condition. OBJECTIVE To study the effect of the 308-nm excimer l... (Source: Dermatologic Surgery)

Vitamin D receptor gene polymorphisms are not associated with alopecia areata

International Journal of Dermatology — Mon, 03 Sep 2007 14:27:04 +0100

International Journal of Dermatology Volume 46, Issue 9, Page 927-929, Sep 2007. Abstract Background It has been demonstrated that the vitamin D receptor (VDR) is strongly expressed in key structures of hair follicles, and a lack of VDR leads to alopecia. We investigated whether there was any association between VDR gene polymorphism... (Source: International Journal of Dermatology)

Alopecia Areata

MedicineNet Mens Health General — Thu, 30 Aug 2007 07:00:00 +0100

Title: Alopecia AreataCategory: Diseases and ConditionsCreated: 4/30/1999 5:53:00 PMLast Editorial Review: 8/30/2007 (Source: MedicineNet Mens Health General)

Dry dermoscopy in clinical treatment of alopecia areata

The Journal of Dermatology — Thu, 23 Aug 2007 09:33:59 +0100

The Journal of Dermatology Volume 34, Issue 9, Page 635-639, Sep 2007. ABSTRACT Although dermoscopy is conventionally utilized with immersion gel for diagnosis of pigmented tumor, we utilized dry dermoscopy, which is dermoscopy without immersion gel, for clinical treatment of alopecia areata (AA). The scalp skin and hair of ... (Source: The Journal of Dermatology)

Lymphocytes, neuropeptides, and genes involved in alopecia areata

Journal of Clinical Investigation — Wed, 01 Aug 2007 04:00:00 +0100

Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell–mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community. (Source: Journal of Clinical Inv...

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Alopecia areata universalis and acute lymphoblastic leukemia

American Journal of Hematology — Fri, 06 Jul 2007 04:00:00 +0100

No abstract. (Source: American Journal of Hematology)

The level of bFGF and TGF-beta 1 in alopecia areata patients’ sera and their role in angiogenesis

Articles of Advances in Dermatology and Allergology - TERMEDIA publishing house — Fri, 22 Jun 2007 09:27:56 +0100

Alopecia areata (AA) is regarded as a non-scarring, inflammatory disease of the hair follicle. The pathophysiology of abnormal hair cycle with premature catagen development in this disease remains unknown. Angiogenesis is defined as the growth of new capillaries from pre-existing blood vessels. In the adult skin this process physiologically occurs in the dermis around anagen hair follicles. Furthermore, anagen follicles possess angiogenic properties. The data suggest that inhibiting angiogenesis leads to retardation of anagen development and initiation of catagen phase ally causing hair loss. The aim of our study was to assess the level of bFGF and TGF-beta 1 in alopecia areata patients’ serum. There were no significant difference in bFGF and TGF-beta 1 levels between alopecia areata...

Changes in distribution pattern of CD8 lymphocytes in the scalp in alopecia areata during treatment with diphencyprone

Archives of Dermatological Research — Sat, 26 May 2007 10:36:49 +0100

Abstract For many years, the role of T lymphocytes was hypothesized as being a major factor responsible for hair loss in alopecia areata (a.a.). While numerous lymphocytic populations were found around hair bulbs, changes in their distribution patterns in the skin during the course and recovery of the disease remain unknown. In the present study, distribution of CD8 lymphocytes in biopsies obtained from a.a. patients was measured before and during treatment using diphencyprone (DCP). Results show about a 600% increase in the number of CD8 lymphocytes under the epithelium and about a 250% increase around hair bulbs and other epidermal appendages during the study. These results were more significant in a group, which had good clinical response to the treatment. No change in ...

What Is Alopecia Areata?

Dermatology News From Medical News Today — Wed, 16 May 2007 19:00:00 +0100

One of the many diseases that can strike people in this world is referred to as alopecia areata. This disease is not well known as the overall diagnosis of this condition was sketchy at best for the past twenty or so years. Thankfully, several research companies have finally found a way to point doctors in the right direction and enable them to give the proper diagnosis when it comes to alopecia areata. [click link for full article] (Source: Dermatology News From Medical News Today)

MedWorm: Alopecia Areata

Cytokines and Other Mediators in Alopecia Areata

Dermatoglyphic patterns in psoriasis, vitiligo and alopecia areata

Clinical Picture of the Week: Alopecia areata

Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey

Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors

Hypnosis in refractory alopecia areata significantly improves depression, anxiety, and life quality but not hair regrowth

Systematic approach to hair loss in women

Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis

Alopecia areata update: Part II. Treatment

Topical Bexarotene for Hair Regrowth in Alopecia Areata

Natural killer cells in atopic and autoimmune diseases of the skin

Vogt-Koyanagi-Harada syndrome: Association with alopecia areata.

Follicular Red Dots: A Novel Dermoscopic Pattern Observed in Scalp Discoid Lupus Erythematosus [Observation]

Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis

The TRAF1/C5 locus confers risk for familial and severe alopecia areata

The TRAF1/C5 locus confers risk for familial and severe alopecia areata.

Diabetic ketoacidosis, thyroiditis and alopecia areata in a child with down syndrome

Complementary and Alternative Medicine in Alopecia Areata

Young sisters who lost their hair cast off their wigs and go to school bald for the first time

Alopecia syphilitica-report of a patient with secondary syphilis presenting as moth-eaten alopecia and a review of its common mimickers.

[What's new in paediatric dermatology?]

[What's new in clinical dermatology?]

Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study [Study]

Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study.

Topical diphencyprone immunotherapy for cutaneous metastatic melanoma

Photodynamic therapy with methyl 5-aminolevulinate acid combined with microneedle treatment in patients with extensive alopecia areata

Four Genes Linked to Alopecia Areata Discovered

Topical diphencyprone immunotherapy for cutaneous metastatic melanoma.

Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy

Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopy

STUDY: Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome

Practical Guidelines for Evaluation of Loose Anagen Hair Syndrome [Study]

Ocular Alterations In Patients of Alopecia Areata F1000 Ranking "Must Read" and "Changes Clinical Practice"

Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations

’Beacon of hope’: Study finds melanocytes are target in alopecia areata

Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids

Five-year experience in the treatment of alopecia areata with DPC

Etanercept: Alopecia areata: case report

Melanocytes: A possible autoimmune target in alopecia areata

Instilled bimatoprost ophthalmic solution in patients with eyelash alopecia areata

Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata

Diagnosing and treating hair loss.

History of atopy or autoimmunity increases alopecia risk

Female Adolescent Hair Disorders

History of atopy or autoimmunity increases risk for alopecia areata

History of atopy or autoimmunity increases risk of alopecia areata

Treatment of alopecia areata with fractional photothermolysis laser

A study of stress management in patients stricken by alopecia areata

Immune-mediated skin lesions in patients treated with anti-tumour necrosis factor alpha inhibitors.

Treatment of alopecia areata in children.

Hair diagnoses and signs: the use of dermatoscopy

Adalimumab: Alopecia areata: case report

Nails and hair

The lived experience of alopecia areata: a qualitative study.

Adalimumab: Alopecia areata: case report.

Prolactine levels in the patients with alopecia areata

[Update on the treatment of alopecia areata.]

Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases

Psoriasiform eruption associated with alopecia areata during infliximab therapy

Traumatic Events in the Past May Increase Vulnerability to Alopecia Areata

Alopecia areata is not associated with <i> Helicobacter pylori</i>

The efficacy of topical diphencyprone in the treatment of alopecia areata

Non-infectious inflammatory disorders of the nail apparatus

Alexithymia in patients with alopecia areata: educational background much more important than traumatic events

Lack of efficacy of topical latanoprost and bimatoprost ophthalmic solutions in promoting eyelash growth in patients with alopecia areata.

Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata

Adalimumab: Alopecia areata: case report

Adalimumab: Alopecia areata: case report.

Capsaicin vs. clobetasol for the treatment of localized alopecia areata

Is Helicobacter pylori infection associated with alopecia areata?

Scalp dermoscopy of androgenetic alopecia in Asian people.

Trace element levels in alopecia areata

Investigation of the Inflammatory Mechanisms in Alopecia Areata.

Trace element levels in alopecia areata

An uncontrolled, open label study of sulfasalazine in severe alopecia areata

Choosing topical corticosteroids.

Bald Is Beautiful?: The Psychosocial Impact of Alopecia Areata

Alopecia areata incognita: True or false?

Adalimumab: Alopecia areata universalis: case report.