MedWorm: Alopecia Areata

Alopecia Areata during Treatment of Psoriasis with Adalimumab and Leflunomide: A Case and Review of the Literature

Skin Pharmacology and Physiology — Mon, 30 Jan 2012 23:00:00 +0100

Skin Pharmacol Physiol 2012;25:107–110 (DOI:10.1159/000335264) (Source: Skin Pharmacology and Physiology)

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CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis

International Journal of Photoenergy — Tue, 24 Jan 2012 18:18:57 +0100

CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, dermatomyositis, primary biliary cirrhosis, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo, bullous pemphigoid, alopecia areata, idiopathic dilated cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis, IgA nephropathy, membranous nephropathy, and pernicious anaemia. It also occurs in healthy blood relatives of patients with autoimmune diseases, suggesting it is genetically determined. Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune dise...

A comment regarding ‘follicular Swiss cheese’ in the diagnosis of alopecia areata

Journal of Cutaneous Pathology — Sat, 21 Jan 2012 04:54:02 +0100

(Source: Journal of Cutaneous Pathology)

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata

Journal of the European Academy of Dermatology and Venereology — Fri, 06 Jan 2012 05:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Alopecia areata associated with haloperidol decanoate long-acting injection.

The Australian and New Zealand Journal of Psychiatry — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Bhattacharya A, Roy D, Hazarika S, Das S, Nath K, Saddichha S PMID: 22247099 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)

Advances in the management of alopecia areata

The Journal of Dermatology — Sat, 31 Dec 2011 05:47:39 +0100

AbstractSpontaneous remission occurs in up to 80% of patients with limited patchy alopecia areata (AA) within 1 year. Therefore, not all patients of AA simplex/multiplex need extensive treatments, and “wait and see” is one of the choices for some patients. However, once the hair loss show progressive course, it is really difficult to manage well and may be recalcitrant to any treatment in some cases. Hair loss symptom is not life‐threatening but severely decreases quality of life. There have been two widely known guidelines for AA from the British Association of Dermatologists and the National Alopecia Areata Foundation (USA). These guidelines have been substantial and provide clues for dermatologists but needed to be updated. Recently, the Japanese Dermatological Association also ...

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Alopecia Areata, Comorbidities, and Age of OnsetAlopecia Areata, Comorbidities, and Age of Onset

Medscape Today Headlines — Thu, 29 Dec 2011 16:27:26 +0100

Is there a link between age of onset and comorbidities in patients with alopecia areata? Medscape Dermatology (Source: Medscape Today Headlines)

Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

Experimental Dermatology — Fri, 16 Dec 2011 05:59:37 +0100

AbstractInterferon‐γ (IFNγ)‐induced collapse of hair follicle (HF) immune privilege (IP) is a key element in the pathogenesis of alopecia areata. In this pilot study, we investigated whether the immunosuppressive neuropeptide, calcitonin gene‐related peptide (CGRP), can protect from and/or restore IFNγ‐induced HF IP‐collapse. After showing that human scalp HFs express CGRP receptor‐like (CRLR) immunoreactivity, anagen HFs were cultured in the presence of IFNγ, with CGRP added before or after. Adding CGRP after IFNγ administration (“restoration assay”) failed to downregulate IFNγ‐induced ectopic MHC class I expression, while MHC class II expression was reduced. However, administering CGRP before IFNγ application (“protection assay”) significantly reduced the IFN...

Renbök phenomenon in a patient with alopecia areata universalis and psoriasis

The Journal of Dermatology — Tue, 13 Dec 2011 05:00:00 +0100

(Source: The Journal of Dermatology)

Alopecia areata triggered or exacerbated by swine flu virus infection

The Journal of Dermatology — Mon, 05 Dec 2011 05:00:00 +0100

(Source: The Journal of Dermatology)

Central centrifugal cicatricial alopecia – an approach to diagnosis and management

International Journal of Dermatology — Tue, 22 Nov 2011 05:52:33 +0100

AbstractCentral centrifugal cicatricial alopecia (CCCA) occurs primarily in African–American women and is the most common cause of scarring hair loss in this population. Since the mid 20th century, hair care practices of African–American women have been associated with CCCA, although there is developing evidence that the etiology of CCCA may be multifactorial. Clinically diagnosing CCCA may be challenging because it can resemble female pattern hair loss, alopecia areata, lichen planopilaris, or telogen effluvium. Therapeutic options are limited, thus the goal of treatment is to prevent progression of disease because once scar formation occurs, it is irreversible. (Source: International Journal of Dermatology)

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Alteration in Hair Texture Following Regrowth in Alopecia Areata: A Case Report [Observation]

Archives of Dermatology — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions The precipitating factor for a change in hair texture in alopecia areata may be a result of treatment, pathophysiologic changes, or a combination of both. Whether the change is triggered at the level of stem cell differentiation, by cytokine or hormonal influences, gene expression during hair follicle development, a combination of all of these, or an unknown cause is a question that remains to be answered. (Source: Archives of Dermatology)

Narrowband ultraviolet B phototherapy for alopecia areata

Photodermatology, Photoimmunology and Photomedicine — Thu, 17 Nov 2011 10:59:41 +0100

SummaryAlthough narrowband ultraviolet B (NB UVB) phototherapy is a well‐established treatment in many dermatosis, there is little evidence of efficacy of this method for alopecia areata (AA) treatment in the literature. We undertook a retrospective review of the 25 AA patients treated with NB UVB. Intramuscular triamcinolone acetonide injections per month were used as concomitant treatment in some patients who did not have any contraindication. Eight patients (32%) received monthly intramuscular corticosteroid injections. Four (22.2%) and two (20%) patients achieved excellent response in extensive patchy hair loss patients and entire scalp hair loss patients, respectively. Four of six patients who achieved excellent response also received monthly intramuscular corticosteroid injections....

Alopecia areata incognita

Journal of the American Academy of Dermatology — Wed, 16 Nov 2011 21:07:47 +0100

To the Editor: I read with great interest the report of the dermoscopic features of alopecia areata incognita (AAI) by Tosti et al and the reply by Rakowska et al. As the first researcher to describe AAI, I feel entitled to participate to the discussion. What I consider AAI mimics a very severe telogen effluvium in a patient with apparently normal hair density. The pull test is impressively positive, and the facial hairs may be affected. Over months to years, diffuse hair thinning evolves, and some patients develop small glabrous areas. The likelihood of finding dystrophic hairs with a random trichogram or biopsy for histopathology is poor. The modified wash test, which collects hairs from the entire scalp, yields at least 350 terminal telogen hairs and may reveal up to 800, with occasi...

Tumor necrosis factor-alpha in patients with alopecia areata

Indian Journal of Dermatology — Fri, 04 Nov 2011 04:00:00 +0100

Conclusion : Our findings support the evidence that elevation of serum TNF-α is associated with AA. The exact role of serum TNF-α in AA should be additionally investigated in future studies. (Source: Indian Journal of Dermatology)

Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case-control study.

The British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact which may bring about anxiety or depression, stress-neuroendocrine-immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. PMID: 22049923 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case‐control study

British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact which may bring about anxiety or depression, stress‐neuroendocrine‐immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. (Source: British Journal of Dermatology)

Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case–control study

British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact, which may bring about anxiety or depression, stress neuroendocrine immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. (Source: British Journal of Dermatology)

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model.

Cell Stress and Chaperones — Tue, 01 Nov 2011 04:00:00 +0100

In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model. Mice with spontaneous AA were treated with subcutaneous quercetin or sham injections. Hair regrowth was observed in lesional areas in all the quercetin-treated mice, but in none of the sham-treated mice. In addition, non-alopecic C3H/HeJ mice were heat-treated to induce alopecia, along with quercetin or sham injections. Whereas 24% of the heat-treated mice with sham injections developed alopecia, none of the mice receiving quercetin injections did. As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control. Furthermore, we showed that systemic delivery of quercetin by intraperitoneal injections...

Anti‐tumor necrosis factor‐α therapies for immune‐mediated and inflammatory skin diseases

Drug Development Research — Tue, 01 Nov 2011 04:00:00 +0100

AbstractAnti‐tumor necrosis factor‐α (TNF‐α) therapies, also called biologic therapies or immunotherapies, are being used increasingly in dermatology, rheumatology, and gastroenterology in the context of established and emerging indications. Anti‐TNF agents target TNF‐α and include infliximab (a chimeric IgG1 monoclonal antibody), adalimumab (a fully human recombinant IgG1 monoclonal antibody), and etanercept (a dimeric fusion protein of TNFR1 linked to the Fc portion of IgG1). Among skin diseases, only plaque psoriasis represents an approved indication for the use of anti‐TNF‐α agents; however, anti‐TNF therapies have been used as off‐label treatments in a plethora of immune‐mediated or inflammatory cutaneous disorders, such as hidradenitis suppurativa, alopecia ar...

Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata

European Journal of Human Genetics — Wed, 26 Oct 2011 04:00:00 +0100

Authors: Lina M Forstbauer, Felix F Brockschmidt, Valentina Moskvina, Christine Herold, Silke Redler, Alexandra Herzog, Axel M Hillmer, Christian Meesters, Stefanie Heilmann, Florian Albert, Margrieta Alblas, Sandra Hanneken, Sibylle Eigelshoven, Kathrin A Giehl, Dagny Jagielska, Ulrike Blume-Peytavi, Natalie Garcia Bartels, Jennifer Kuhn, Hans Christian Hennies, Matthias Goebeler, Andreas Jung, Wiebke K Peitsch, Anne-Katrin Kortüm, Ingrid Moll, Roland Kruse, Gerhard Lutz, Hans Wolff, Bettina Blaumeiser, Markus Böhm, George Kirov, Tim Becker, Markus M Nöthen & Regina C Betz (Source: European Journal of Human Genetics)

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Alopecia Areata

MedicineNet Mens Health General — Mon, 17 Oct 2011 07:00:00 +0100

Title: Alopecia AreataCategory: Diseases and ConditionsCreated: 4/30/1999 5:53:00 PMLast Editorial Review: 10/17/2011 (Source: MedicineNet Mens Health General)

Patchy hair loss could be caused by alopecia areata

Monsters and Critics Health News — Mon, 10 Oct 2011 03:06:21 +0100

(Source: Monsters and Critics Health News)

Use of a rugby helmet brace for postoperative treatment of muscular torticollis.

Orthopedics — Thu, 06 Oct 2011 12:30:03 +0100

Authors: Yamada N, Kim WC, Hosokawa M, Yoshida T, Mouri H, Oka Y, Kotoura Y, Nakase M, Nishida A, Kusakabe T, Kubo T Abstract Prior to 1992, our postoperative management for congenital muscular torticollis consisted of either plaster cast immobilization or no immobilization, depending on the patient's age and the degree of contracture. However, some patients required further surgery and developed complications. In 1992, we produced rugby helmet braces for postoperative management. The purpose of this study was to compare the clinical results of the previous postoperative management with the results achieved using rugby helmet braces.Twenty-five children aged younger than 6 years underwent caudal partial resection of the sternocleidomastoid muscle. Twelve children aged 6 years and o...

Increased retinol-binding protein (RBP) 4 and anti-RBP4 antibody in alopecia areata.

The British Journal of Dermatology — Sat, 01 Oct 2011 04:00:00 +0100

Conclusions Our data demonstrate that AA is associated with increased serum levels of RBP4 and positive IgG immunoreactivity against recombinant human RBP4. These results suggest that the major components for the retinoic acid biosynthesis pathway may be crucially involved in the pathogenic process of AA. PMID: 21711327 [PubMed - in process] (Source: The British Journal of Dermatology)

Intermediate Uveitis and Alopecia Areata: Is There a Relationship? Report of 3 Pediatric Cases

PEDIATRICS — Fri, 30 Sep 2011 04:00:00 +0100

Three previously healthy children, aged 5, 8, and 15 years, with idiopathic intermediate uveitis (IU) and alopecia areata (AA) are described. These are the first 3 cases of which we are aware with this coexistence. The results of extensive diagnostic evaluations were negative in all 3 cases. AA preceded the diagnosis of bilateral IU in 1 child and followed within several months after IU diagnosis in 2 children. The severity of uveitis ranged from mild to sight-threatening, and hair loss ranged from local lesions in 2 cases to total alopecia in 1 case. Pathogenesis of both diseases is discussed. Theoretically, the coexistence of IU and AA might be based on the similarities in their complex pathogenesis. However, more research is needed to evaluate if the coexistence is based on an associati...

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Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

British Journal of Dermatology — Thu, 29 Sep 2011 04:43:09 +0100

Renbok phenomenon between psoriasis and alopecia areata

Clinical And Experimental Dermatology — Sat, 24 Sep 2011 14:05:07 +0100

(Source: Clinical And Experimental Dermatology)

New insights in segmental vitiligo: case report and review of theories

British Journal of Dermatology — Thu, 22 Sep 2011 06:51:28 +0100

SummarySegmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto‐immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune mediated overlap between the two subtypes.In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo nevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared auto‐immune mediated process,...

Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata

British Journal of Dermatology — Wed, 21 Sep 2011 04:00:00 +0100

Conclusions: DNA methylation and histone modifications statuses are altered in PBMCs of AA patients, possibly due to the deregulation of epigenetic regulatory genes. These changes may contribute to the activation of pathological immune responses in AA. (Source: British Journal of Dermatology)

New insights in segmental vitiligo: case report and review of theories.

The British Journal of Dermatology — Wed, 21 Sep 2011 04:00:00 +0100

Authors: van Geel N, Mollet I, Brochez L, Dutré M, De Schepper S, Verhaeghe E, Lambert J, Speeckaert R Abstract Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto-immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo nevus. To our knowledge, this is the first case with this exceptional...

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Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata.

The British Journal of Dermatology — Wed, 21 Sep 2011 04:00:00 +0100

Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in Alopecia areata.

Genomics — Sat, 17 Sep 2011 04:00:00 +0100

Authors: Coda AB, Sinha AA Abstract Alopecia areata (AA), a non-scarring inflammatory hair loss disorder, is a complex disease determined by genetic and environmental factors that remain largely unknown. Re-analysis of genome-wide microarray data in 9 patient blood and 10 skin samples revealed transcriptional "hot spots" at chromosomes 1q21-q32, 11q12-q14, and 16p13-p13.3 (blood) and 6p21.3, 12q12-q13, and 17q12-q24 (skin) harboring high densities of dysregulated genes. We then integrated AA associated gene expression profiles with previous genome-wide genetic analyses to identify a subset of 112 dysregulated genes that map to putative susceptibility loci. Finally, we analyzed AA patients stratified by defined clinical characteristics, including a history of atopy, autoimmune disea...

Vertical vs. transverse sections of scalp biopsy specimens: a pilot study on the comparison of the diagnostic value of two techniques in alopecia

Clinical And Experimental Dermatology — Thu, 15 Sep 2011 04:00:00 +0100

Conclusion. If only a single biopsy specimen is available, it may be preferable to have transverse sections in cases of suspected noncicatricial alopecia, and vertical sections in cases of suspected lichen planopilaris. Either type of sectioning is suitable for cicatricial alopecia when lichen planopilaris is clinically unlikely. (Source: Clinical And Experimental Dermatology)

Utility of dermoscopy in alopecia areata

Indian Journal of Dermatology — Sat, 10 Sep 2011 04:00:00 +0100

Conclusions: The most common dermoscopic finding of AA in our study was yellow dots, followed by black dots, broken hairs, short vellus hair and tapering hairs. Dermoscopic findings were not affected by the type of AA or the severity of the disease. (Source: Indian Journal of Dermatology)

Kawasaki Disease and Alopecia Areata: Coincidence or a True Association?

Pediatric Dermatology — Fri, 09 Sep 2011 04:00:00 +0100

Abstract: A 10‐year‐old boy presented with fever, stiff neck, and rash over the legs. During the course of his hospital stay, the clinical picture gradually evolved, and he met the criteria for Kawasaki disease (KD) on the seventh day of hospitalization. During this period, he also developed alopecia areata. He was managed with intravenous immunoglobulin, aspirin, and intralesional triamcinolone. This is the first case of alopecia areata with KD in the literature, and it does not appear to be a mere coincidence. We discuss the probable mechanisms of alopecia areata with KD, an association that has not been reported before. (Source: Pediatric Dermatology)

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Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata.

The British Journal of Dermatology — Tue, 06 Sep 2011 04:00:00 +0100

Conclusion: Antibodies against TH can be present in patients with AA unrelated to APS1. Humoral immune responses against tyrosinase, TRP-1, TRP-2, gp100 and MelanA are not prevalent in AA patients. Overall, a dominant melanocyte-specific B cell autoantigen in AA has yet to be identified. PMID: 21895622 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata

British Journal of Dermatology — Mon, 05 Sep 2011 23:00:00 +0100

Conclusion: Antibodies against TH can be present in patients with AA unrelated to APS1. Humoral immune responses against tyrosinase, TRP‐1, TRP‐2, gp100 and MelanA are not prevalent in AA patients. Overall, a dominant melanocyte‐specific B cell autoantigen in AA has yet to be identified. (Source: British Journal of Dermatology)

Alopecia areata responds to skin-directed therapy

Modern Medicine — Tue, 30 Aug 2011 17:21:13 +0100

Although large, randomized, controlled trials of topical treatments for alopecia areata (AA) are lacking, experts say many such treatments provide varying degrees of success. When it comes to AA, says Jerry Shapiro, M.D., "Some dermatologists still believe nothing works." He is adjunct professor, department of dermatology, New York University, New York. (Source: Modern Medicine)

Vitiligo: A comprehensive overview: Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up

Journal of the American Academy of Dermatology — Fri, 12 Aug 2011 16:59:33 +0100

Vitiligo is an acquired pigmentary disorder of unknown etiology that is clinically characterized by the development of white macules related to the selective loss of melanocytes. The prevalence of the disease is around 1% in the United States and in Europe, but ranges from less than 0.1% to greater than 8% worldwide. A recorded predominance of women may reflect their greater willingness to express concern about cosmetically relevant issues. Half of all patients develop the disease before 20 years of age. Onset at an advanced age occurs but is unusual, and should raise concerns about associated diseases, such as thyroid dysfunction, rheumatoid arthritis, diabetes mellitus, and alopecia areata. Generalized vitiligo is the most common clinical presentation and often involves the face and acra...

The effect of a 1550 nm fractional erbium–glass laser in female pattern hair loss

Journal of the European Academy of Dermatology and Venereology — Wed, 03 Aug 2011 23:00:00 +0100

Conclusion A 1550 nm fractional erbium–glass laser irradiation may be an effective and safe treatment option for women with female pattern hair loss. (Source: Journal of the European Academy of Dermatology and Venereology)

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Nonsegmental Vitiligo and Autoimmune Mechanism

Advances in Pharmacological Sciences — Tue, 26 Jul 2011 17:23:32 +0100

Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo. (Source: Advances in Pharmacolo...

Alopecia Areata After Biologic Therapy: Report of a Case Related to Adalimumab.

Actas Dermo-Sifiliograficas — Mon, 25 Jul 2011 23:00:00 +0100

Authors: Neila J, Carrizosa A, Ceballos C, Camacho FM PMID: 21798487 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Alteration in Hair Texture Following Regrowth in Alopecia Areata: A Case Report [Observation]

Archives of Dermatology — Sun, 17 Jul 2011 23:00:00 +0100

Cure of alopecia areata after eradication of Helicobacter pylori: A new association?

World Journal of Gastroenterology — Thu, 14 Jul 2011 04:00:00 +0100

Authors: Campuzano-Maya G Abstract Alopecia areata is a disease of the hair follicles, with strong evidence supporting autoimmune etiology. Alopecia areata is frequently associated with immune-mediated diseases with skin manifestations such as psoriasis and lichen planus, or without skin manifestations such as autoimmune thyroiditis and idiopathic thrombocytopenic purpura. Helicobacter pylori (H. pylori) infection is present in around 50% of the world's population and has been associated with a variety of immune-mediated extra-digestive disorders including autoimmune thyroiditis, idiopathic thrombocytopenic purpura, and psoriasis. A case of a 43-year old man with an 8-mo history of alopecia areata of the scalp and beard is presented. The patient was being treated by a dermatologist...

Botulinum toxin treatment of secondary headaches and cranial neuralgias: a review of evidence.

Acta Neurologica Scandinavica. Supplementum — Wed, 13 Jul 2011 16:15:08 +0100

Conclusion - At present, BoNT cannot be firmly recommended as an evidence-based treatment in secondary headaches or cranial neuralgias. PMID: 21711257 [PubMed - in process] (Source: Acta Neurologica Scandinavica. Supplementum)

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Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata

Lasers in Medical Science — Fri, 08 Jul 2011 06:32:37 +0100

Abstract Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser comb to alleviate the symptoms of AA in a C3H/HeJ mouse model for AA. Fourteen C3H/HeJ mice with induced AA were used in this study. Two were killed to confirm AA through histology. The remaining 12 mice were randomized into two groups; group I received HairMax LaserComb (wavelength: 655 nm, beam diameter <5 mm; divergence 57 mrad; nine lasers) for 20 s daily, three times per week for a total of 6 weeks; group II was treated similarly,...

Delayed type hypersensitivity‐induced myeloid‐derived suppressor cells regulate autoreactive T cells

European Journal of Immunology — Sun, 03 Jul 2011 23:00:00 +0100

AbstractMild but efficient treatments of autoimmune diseases are urgently required. One such therapy, long‐term maintenance of chronic delayed‐type hypersensitivity (DTH) has been described for alopecia areata (AA), a hair follicle‐affecting autoimmune disease. The molecular mechanisms underlying the therapeutic efficacy are unknown, but may involve myeloid‐derived suppressor cells (MDSCs).AA‐affected mice were treated with squaric acid dibutyl ester (SADBE). The immunoreactivity of SADBE‐treated AA lymphocytes and of AA lymphocytes co‐cultured with SADBE‐induced MDSCs was analyzed. The curative effect of SADBE was abolished by all‐transretinoic acid, which drives MDSCs into differentiation, confirming a central role for MDSCs in therapeutic SADBE‐treatment. SADBE and S...

Uric acid : A new antioxidant in patients with pemphigus vulgaris

Indian Journal of Dermatology — Wed, 29 Jun 2011 23:00:00 +0100

Conclusions: Uric acid as an antioxidant in our study had similar changes to previous studies in the field of other diseases but selenium, bilirubin, and glutathione peroxidase did not differ between patients and controls. (Source: Indian Journal of Dermatology)

Botulinum toxin treatment of secondary headaches and cranial neuralgias: a review of evidence

Acta Neurologica Scandinavica — Wed, 29 Jun 2011 19:47:47 +0100

Conclusion – At present, BoNT cannot be firmly recommended as an evidence‐based treatment in secondary headaches or cranial neuralgias. (Source: Acta Neurologica Scandinavica)

Clinical profile and impact on quality of life: Seven years experience with patients of alopecia areata

Indian Journal of Dermatology, Venereology and Leprology — Tue, 28 Jun 2011 23:00:00 +0100

Conclusions: Severe forms of alopecia areata had a major impact on the psychosocial well-being of the patients. These individuals had to be treated early, and they required more than just prescription drugs. Educational and psychological support in addition to medical therapy for AA could improve their long-term physical outcomes. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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Differential expression of stem cell markers in lichen planopilaris and alopecia areata

British Journal of Dermatology — Mon, 27 Jun 2011 23:00:00 +0100

(Source: British Journal of Dermatology)

Increased retinol‐binding protein 4 (RBP4) and anti‐RBP4 antibody in alopecia areata

British Journal of Dermatology — Mon, 27 Jun 2011 23:00:00 +0100

Conclusion: Our data demonstrate that AA is associated with increased serum levels of RBP4 and positive IgG immunoreactivity against recombinant human RBP4. These results suggest that the major components for RA biosynthesis pathway may be crucially involved in the pathogenic process of AA. (Source: British Journal of Dermatology)

Differential expression of stem cell markers in lichen planopilaris and alopecia areata.

The British Journal of Dermatology — Mon, 27 Jun 2011 23:00:00 +0100

Authors: Sellheyer K, Atanaskova-Mesinkovska N, Nelson P, Bergfeld WF PMID: 21711336 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Increased retinol-binding protein 4 (RBP4) and anti-RBP4 antibody in alopecia areata.

The British Journal of Dermatology — Mon, 27 Jun 2011 23:00:00 +0100

Lichenoid red tatoo reaction and alopecia areata

International Journal of Dermatology — Mon, 27 Jun 2011 18:02:03 +0100

(Source: International Journal of Dermatology)

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Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study

Journal of the European Academy of Dermatology and Venereology — Wed, 22 Jun 2011 16:38:02 +0100

Conclusion The frequencies of autoimmune and atopic diseases were not different between adult and paediatric patients and the control group. We did not find a statistically significance between disease severity and personal and family history of autoimmune disease in the two groups. Disease severity was not related to nail changes in the adult group. However, severe alopecia areata was more prevalent in children with nail changes. Furthermore, ophiasis pattern was more prevalent in the paediatric group with nail changes compared with the adult group. (Source: Journal of the European Academy of Dermatology and Venereology)

Genetic association of HLA‐DQB1 and HLA‐DRB1 polymorphisms with alopecia areata in the Italian population

British Journal of Dermatology — Tue, 21 Jun 2011 04:00:00 +0100

Conclusion Our data show a correlation between the HLA‐DQB1 locus and the occurrence of AA in Italy supporting DQB1*03(DQ7) as a predisposing allele for the disease and the relevance of the HLA genetic test in the clinical management of AA. (Source: British Journal of Dermatology)

Genetic association of HLA‐DQB1 and HLA‐DRB1 polymorphisms with Alopecia areata in the Italian population.

British Journal of Dermatology — Mon, 20 Jun 2011 23:00:00 +0100

AbstractAlopecia areata (AA) is a multifactorial disease characterized by hair loss especially from the scalp. As for other autoimmune conditions, the major histocompatibility complex (HLA) region is associated with AA susceptibility. We performed a case‐control study to investigate whether HLA‐DQB1 and ‐DRB1 alleles predispose to Alopecia areata in the Italian population. HLA class II typing was performed in 85 AA patients and 210 healthy controls from the same ethnic group. An increased frequency of DQB1*03, coding for DQ7 heterodimers, and a decreased rate of DQB1*06 allele were observed in patients when compared with controls having the highest and significant difference in the group of cases with a more severe phenotype (AA>50% patients versus controls: p=4.5x10−3, pc=0.031...

Genetic association of HLA-DQB1 and HLA-DRB1 polymorphisms with Alopecia areata in the Italian population.

The British Journal of Dermatology — Mon, 20 Jun 2011 23:00:00 +0100

Authors: Megiorni F, Pizzuti A, Mora B, Rizzuti A, Garelli V, Maxia C, Carlesimo M, Fotruna MC, Delle Chiaie R, Cavaggioni G, Rossi A Alopecia areata (AA) is a multifactorial disease characterized by hair loss especially from the scalp. As for other autoimmune conditions, the major histocompatibility complex (HLA) region is associated with AA susceptibility. We performed a case-control study to investigate whether HLA-DQB1 and -DRB1 alleles predispose to Alopecia areata in the Italian population. HLA class II typing was performed in 85 AA patients and 210 healthy controls from the same ethnic group. An increased frequency of DQB1*03, coding for DQ7 heterodimers, and a decreased rate of DQB1*06 allele were observed in patients when compared with controls having the highest and significa...

Multiple paraneoplastic syndromes: Myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma

Journal of the Neurological Sciences — Sun, 19 Jun 2011 23:00:00 +0100

We describe a thymoma patient with diagnoses of myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with a thymoma. After thymectomy, the weakness, vitiligo, alopecia and mucocutaneous lesions were improving progressively, possibly implicating the thymoma in initiating these autoimmune conditions. We believe that this is the first report of this particular combination of multiple paraneoplastic syndromes associated with thymoma. (Source: Journal of the Neurological Sciences)

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Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates

Journal of the American Academy of Dermatology — Sun, 19 Jun 2011 23:00:00 +0100

Conclusions: Although most specimens showed evidence of a peribulbar lymphocytic infiltrate (84%), a higher percentage showed evidence of follicles in catagen/telogen phase (93%) and evidence of miniaturization of follicles (90%). This could lead to an incorrect diagnosis of trichotillomania or pattern alopecia. Pigment casts within the hair canal were also found in a significant number of follicles, especially in catagen follicles, creating further potential for misdiagnosis as trichotillomania. A significant percentage showed evidence of eosinophils (44%), melanin (84%), and lymphocytes (94%) in fibrous tracts. These features are particularly helpful when a peribulbar lymphocytic infiltrate is lacking. Vertical and transverse sections appear comparable. (Source: Journal of the American ...

Concurrence of alopecia areata and vitiligo at the same anatomical site

Australasian Journal of Dermatology — Wed, 08 Jun 2011 23:00:00 +0100

ABSTRACTBoth alopecia areata and vitiligo are common skin disorders that are considered to be caused by an autoimmune response targeted to hair follicle and melanocyte antigens, respectively. The association of these two diseases in the same patient is well known, however, coexistence of alopecia areata and vitiligo within the same lesion is very rare. Herein, we report an 8‐year‐old boy who had colocalization of alopecia areata and vitiligo on the frontal portion of his scalp. (Source: Australasian Journal of Dermatology)

Adalimumab/etanercept: Alopecia areata: 9 case reports

Reactions — Sun, 05 Jun 2011 19:54:23 +0100

(Source: Reactions)

Therapeutic effect observation on electroacupuncture plus acupoint injection for alopecia areata

Journal of Acupuncture and Tuina Science — Sun, 05 Jun 2011 05:48:23 +0100

Conclusion Combined electroacupuncture and acupoint injection of Mecobalamin is effective for alopecia areata. Content Type Journal ArticlePages 165-167DOI 10.1007/s11726-011-0501-9Authors Ze Jin, No.2 Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine, Harbin, 150001 P. R. ChinaFei Yang, Heilongjiang University of Traditional Chinese Medicine, Harbin, 150040 P. R. ChinaYulin Wang, No.2 Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine, Harbin, 150001 P. R. China Journal Journal of Acupuncture and Tuina ScienceOnline ISSN 1993-0399Print ISSN 1672-3597 Journal Volume Volume 9 Journal Issue Volume 9, Number 3 (Source: Journal of Acupuncture and Tuina Science)

Clinical observation on acupuncture treatment of alopecia areata

Journal of Acupuncture and Tuina Science — Sun, 05 Jun 2011 05:48:00 +0100

Conclusion Acupuncture is better than medications in the treatment of alopecia areata. Content Type Journal ArticlePages 162-164DOI 10.1007/s11726-011-0500-xAuthors Qiyu Zhu, Department of Chinese Medicine, Han Jiang Hospital, Han Jiang Group, Danjiangkou, Hubei, 442700 P. R. ChinaFanghua Wu, Department of Chinese Medicine, Han Jiang Hospital, Han Jiang Group, Danjiangkou, Hubei, 442700 P. R. China Journal Journal of Acupuncture and Tuina ScienceOnline ISSN 1993-0399Print ISSN 1672-3597 Journal Volume Volume 9 Journal Issue Volume 9, Number 3 (Source: Journal of Acupuncture and Tuina Science)

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Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study

Journal of the American Academy of Dermatology — Thu, 26 May 2011 04:00:00 +0100

Conclusions: AA is related to various atopic and autoimmune diseases. Different associated diseases in each onset age group of AA can allow clinician to efficiently investigate specific comorbidities. (Source: Journal of the American Academy of Dermatology)

Prognostic factors in methylprednisolone pulse therapy for alopecia areata

The Journal of Dermatology — Wed, 18 May 2011 23:00:00 +0100

AbstractMany treatments induce remission in patients with alopecia areata. Systemic steroids, for example, are effective in the treatment of severe alopecia areata but have many side‐effects. To avoid these side‐effects, high‐dose bolus infusions of methylprednisolone have been used to treat severe alopecia areata. The purpose of this study was to evaluate the prognostic factors associated with pulse therapy and to establish proper indications for methylprednisolone pulse therapy. Seventy patients with severe alopecia areata were treated i.v. with methylprednisolone on 3 consecutive days. All of the patients had rapid and extensive hair loss with the bald area exceeding 50% of the scalp. Seventy percent of the patients showed terminal hair growth and 41.4% showed complete responses w...

Topical immunotherapy with diphenylcyclopropenone of patients with alopecia areata – a large retrospective study on 142 patients with a self‐controlled design

Journal of the European Academy of Dermatology and Venereology — Fri, 13 May 2011 23:00:00 +0100

Conclusion Topical immunotherapy with DCP of patients with AA is rather effective and mostly well tolerated. The extent of hair loss before therapy is the main predictor for the therapeutic success of DCP. However, DCP therapy is associated with a high degree of relapse of which patients should be well informed. (Source: Journal of the European Academy of Dermatology and Venereology)

Alopecia areata incognita

Clinics — Fri, 06 May 2011 18:47:38 +0100

Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma, a malignancy that accounts for about 80% of deaths from skin cancer. Because the diagnosis of melanoma at an early stage is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers is essential, as well as the creation of recommended preventative measures that must be taken by these patients. (Source: Clinics)

Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan

Journal of Dermatological Science — Wed, 04 May 2011 23:00:00 +0100

Conclusions: Psoriasis was associated with a significantly increased risk of comorbidities, especially for those patients with moderate to severe disease. These health associations should be taken into consideration when evaluating the burdens of psoriasis and designing effective treatment plans. (Source: Journal of Dermatological Science)

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Concomitant Manifestation of Pili Annulati and Alopecia Areata: Coincidental Rather than True Association.

Acta Dermato-Venereologica — Mon, 02 May 2011 23:00:00 +0100

Authors: Giehl KA, Schmuth M, Tosti A, De Berker DA, Crispin A, Wolff H, Frank J The autosomal dominantly inherited hair disorder pili annulati is characterized by alternating light and dark bands of the hair shaft. Concomitant manifestation of pili annulati with alopecia areata has been reported previously on several occasions. However, no systematic evaluation of patients manifesting both diseases has been performed. We studied the simultaneous or sequential occurrence of pili annulati and alopecia areata in individuals diagnosed in different European academic dermatology units. We included 162 Caucasian individuals from 14 extended families, comprising 76 affected and 86 unaffected family members. Statistical analysis showed that the frequency of alopecia areata among patients with ...

[Alopecia areata during anti-TNF alpha therapy: Nine cases.]

Annales de Dermatologie et de Cenereologie — Sun, 01 May 2011 11:30:04 +0100

We present nine cases of alopecia areata (AA) developed in patients treated with TNF-α blocking agents. PATIENTS AND METHODS: Nine cases are described: five men and four women of mean age 39.2years (range: 29-54years). Two patients had a past history of alopecia areata. The anti-TNF given was adalimumab (Humira(®)) in eight cases and etanercept (Enbrel(®)) in one case. The time lapse to development of AA following introduction of the anti-TNF alpha agent was between six weeks and eight months (mean: 4.2months). There were five cases of patchy AA and four of AA universalis. Anti-TNF alpha treatment was stopped in all patients. Complete regrowth was seen in five patients. Two patients showed no improvement. In two patients, partial hair regrowth (<50%) was seen after systemic corticost...

Dermatologic therapy: Alopecia areata update

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

(Source: Dermatologic Therapy)

Alopecia areata: Support groups and meetings – how can it help your patient?

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTMany people with alopecia areata find the fellowship of the support groups provides them with the help they need to cope. They find that they are not alone, how others have coped, what doctors and treatments have been tried, and what the results have been. The National Alopecia Areata Foundation offers support groups throughout the world to refer patients. (Source: Dermatologic Therapy)

Camouflage technique for alopecia areata: What is a patient to do?

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

This article discusses the currently available options for those who wish to pursue camouflage of hair loss involving the scalp, eyebrows, and eyelashes. (Source: Dermatologic Therapy)

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Investigative guidelines for alopecia areata

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

This report will give both the investigator and clinician guidelines for clinical trial design that will take into account variables known to effect efficacy results such as baseline severity, pattern, and duration of hair loss, age of the subject, and concomitant conditions that may impact on potential regrowth. Reliable methods of assessment of efficacy and response criteria that will enable direct comparison of results between agents will also be discussed. (Source: Dermatologic Therapy)

Systemic treatment for alopecia areata

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTOf the world population, 1.7% is suffering from alopecia areata at some point in their lives. The exact etiology of this disease is still unknown, and the course of the disease is unpredictable. Effective treatments, especially for severe multifocal alopecia areata, alopecia areata totalis, and alopecia areata universalis, are lacking. The present article will discuss side effects and relapse rates of different systemic agents for treatment of severe and rapid progressive alopecia areata. (Source: Dermatologic Therapy)

The genetics of alopecia areata: What's new and how will it help our patients?

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTIn the United States, alopecia areata (AA) is the most prevalent autoimmune disease, affecting approximately 5.3 million people, including males and females of all ages and across all ethnic groups. AA affects more individuals than most other autoimmune diseases combined, and yet despite its prevalence, there is little information on the underlying pathogenesis and there are currently no evidence‐based treatments available to treat or cure this disease. Genetics has provided a valuable tool for gaining insight into disease pathology. We recently completed the first genome‐wide association study (GWAS) in AA and successfully identified at least eight regions in the genome with evidence for association to AA. Importantly, this work identifies a discrete set of genes, some of whic...

Etiopathogenesis of alopecia areata: Why do our patients get it?

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

This article provides some insights into the etiopathogenesis of AA and why some people develop it. The current knowledge on the pathogenesis of AA is summarized and some of the recent hypotheses and studies on AA are presented to allow for a fuller understanding of the possible biological mechanisms of AA. (Source: Dermatologic Therapy)

Alopecia areata: Clinical presentation, diagnosis, and unusual cases

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTAlopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long‐lasting, and severe cases have a less favorable prognosis. The clinical diagnosis is made by the aspect of hairless patches with a normal skin and preserved follicular ostia. Exclamations mark hairs and a positive pull test signal activity. D...

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Topical and intralesional therapies for alopecia areata

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

This article will review the available topical and intralesional agents that are used in the treatment of alopecia areata and suggest a management approach based on the age of the patient and extent of the disease. (Source: Dermatologic Therapy)

Treatment of alopecia areata: “What is new on the horizon?”

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTNew drug treatment opportunities based on the results of a genome‐wide association study, which implicate T cell and natural killer (NK)‐cell activation pathways, are leading to new approaches in future clinical trials of alopecia areata. Special attention is being given to the UL 16‐binding protein (ULBP3) gene cluster on chromosome 6q25, as these genes make the NKG2D‐activating ligand or signal that can trigger the NKG2D receptor, initiating an autoimmune response. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease. It is now postulated that the characteristic T cell “swarm of bees” infiltrate seen in alopecia areata is the result of T cells being attracted to the hair follicle by NKG2D‐act...

Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician?

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTAlopecia areata (AA) is often easy to diagnose but a scalp biopsy for horizontal sectioning is routine in this research clinic. The characteristic histological feature of AA is the peribulbar and intrabulbar mononuclear cell infiltrate, which occurs in the acute stage of the disease but may be absent in biopsies taken at a later stage. AA evolves through acute, subacute, chronic, and recovery phases. Increased numbers of terminal catagen and telogen hairs are found in the acute and perhaps subacute stages with increased numbers of miniaturized, vellus‐like hairs in the subacute and chronic stages. Thus, it is important for clinicians and pathologists to recognize the different phases of AA, so that in the absence of the classic findings of a peribulbar lymphocytic infiltrate, a d...

Vitiligo and alopecia areata associated with subclinical/clinical hypothyroidism.

Skinmed — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Sehgal VN The parents of an 18-year-old woman had noticed white hair while combing their daughter's hair 12 years ago. They found tiny white spots on her scalp, but she was asymptomatic. The spots have since progressed. Examination of the affected skin on the scalp was marked by the presence of a chalky/ivory white macule, 8 to 10 cm in diameter, conforming to that of segmental (zosteriformis) vitiligo (Figure 1). The lesions were located on the temporoparietal region of the scalp. The hair over the macules was white (leukotrichia) and dry, coarse, and brittle. The patient's nails were thin and dull. Her thyroid profile revealed the following: triiodothyronine, 1.12 nmol/L (0.95-2.5 nmol/L); thyroxine, 69.21 nmol/L (60.0-120.0 nmol/L); and thyroid-stimulating hormone, 6.26 mic...

Hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double‐blind, randomized pilot clinical trial of efficacy

Journal of the European Academy of Dermatology and Venereology — Tue, 26 Apr 2011 23:00:00 +0100

Conclusion Triiodothyronine in the studied dosage and formulation was safe but not more effective than placebo. However, newer thyroid hormone analogues might be more effective and evaluating their effects probably warrants further consideration. (Source: Journal of the European Academy of Dermatology and Venereology)

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Efficacy and tolerability of methotrexate in severe childhood alopecia areata

British Journal of Dermatology — Sun, 24 Apr 2011 23:00:00 +0100

(Source: British Journal of Dermatology)

Efficacy and tolerability of methotrexate in severe childhood alopecia areata.

The British Journal of Dermatology — Sun, 24 Apr 2011 23:00:00 +0100

Authors: Royer M, Bodemer C, Vabres P, Pajot C, Barbarot S, Paul C, Mazereeuw J PMID: 21517797 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Emergence of trichoscopic yellow dots by topical corticosteroid in alopecia areata mimicking frontal fibrosing alopecia: A case report

The Journal of Dermatology — Mon, 04 Apr 2011 23:00:00 +0100

(Source: The Journal of Dermatology)

Vitiligo and associated autoimmune disorders: A retrospective hospital-based study in Mumbai, India.

Allergologia et Immunopathologia — Mon, 04 Apr 2011 23:00:00 +0100

CONCLUSION: Association of vitiligo with other autoimmune diseases emphasizes autoimmune aetiology of vitiligo. This study also emphasizes the need to actively look for, and if necessary, investigate patients with vitiligo for other autoimmune diseases. PMID: 21474231 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Prevalence of dermatological disorders in Japan: A nationwide, cross‐sectional, seasonal, multicenter, hospital‐based study

The Journal of Dermatology — Tue, 29 Mar 2011 15:46:31 +0100

In conclusion, this hospital‐based study highlights the present situation regarding dermatological patients in the early 21st century in Japan. (Source: The Journal of Dermatology)

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Phenotypic and dermatological manifestations in Down Syndrome.

Dermatol Online J — Fri, 18 Mar 2011 10:15:07 +0100

This study was conducted over a 2-year period to evaluate the frequency of phenotypic and dermatologic manifestations in patients with Down syndrome in south India. The most common phenotypic manifestations that characterize DS include the epicanthic fold (93.7%), brachicephaly (90.6%), flat nasal bridge (84.2%), upward angle of eyes (83.2%), wide gap between first and second toe (81.1%), clinodactyly (77.9%), small nose (74.7%), short broad neck (72.6%), single palmar crease (61.1%), increased nuchal skin fold (61.1%), and fissured tongue (52.6%). The most common dermatological manifestation seen in patients with DS were lichenification, xerosis, dental anomaly, fine, sparse hair, and delayed dentition. Alopecia areata was seen in 9.4 percent of patients and tended to be severe. Infection...

National Alopecia Areata Foundation Selects Lab For New Treatment Development Program

Health News from Medical News Today — Mon, 14 Mar 2011 10:00:00 +0100

The National Alopecia Areata Foundation (NAAF) is focusing on its mission of research and launching a new Treatment Development Program. With this new program, NAAF is pleased to announce the University of Colorado Denver, under the direction of George Eisenbarth, MD, has been selected to conduct the initial experiments on autoantibodies in alopecia areata. Dr. Eisenbarth has established a National Institutes of Health reference laboratory in Denver to identify antibody specificities in autoimmune disease... (Source: Health News from Medical News Today)

The coudability sign of alopecia areata: the real story

Clinical And Experimental Dermatology — Fri, 11 Mar 2011 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Environmental stress but not subjective distress in children or adolescents with alopecia areata

Journal of Psychosomatic Research — Thu, 10 Mar 2011 00:00:00 +0100

Conclusion: Alopecia areata is a complex skin disorder in juvenile patients whose conscious experience of distress is often absent and that might be precipitated by stressful life events in individuals under the influence of defective family functioning or biological vulnerability. (Source: Journal of Psychosomatic Research)

[Alopecia areata: a retrospective study of the paediatric dermatology department (2000-2008)].

Acta Medica Portuguesa — Tue, 01 Mar 2011 05:00:00 +0100

Discussion: Our findings are similar to those reported in other studies. Epidemiologic studies of AA are available in adulthood but there is a paucity of literature on children with AA. A holistic approach is important in the management of childhood AA as the disease can have a severe psychologic impact on an individual's well-being. PMID: 22011591 [PubMed - in process] (Source: Acta Medica Portuguesa)

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Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.

Pharmacological Reports — Tue, 01 Mar 2011 00:00:00 +0100

Authors: Rogosnitzky M, Danks R Cepharanthine (CEP) is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopeci...

Check-up alopecia areata

The Irish Times - Health — Tue, 22 Feb 2011 01:07:46 +0100

A couple of months ago I noticed a number of bald spots at the back of my head. My GP says it’s a type of alopecia. (Source: The Irish Times - Health)

A Case-control Study on Family Dysfunction in Patients with Alopecia Areata, Psoriasis and Atopic Dermatitis.

Acta Dermato-Venereologica — Mon, 21 Feb 2011 00:00:00 +0100

In conclusion, family dysfunction may play an important role in the onset or the exacerbation of psoriasis, alopecia, and atopic dermatitis. PMID: 21336474 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

Psychosocial Stress and Coping in Alopecia Areata: A Questionnaire Survey and Qualitative Study Among 45 Patients.

Acta Dermato-Venereologica — Thu, 03 Feb 2011 00:00:00 +0100

Authors: Matzer F, Egger JW, Kopera D The controversial role of psychosocial stress in alopecia areata has been discussed widely, but there has been little research into patients' subjective stress experiences and coping. The aim of this study was to explore general and specific coping strategies in alopecia areata and to assess the role of psychosocial stress in the onset and course of alopecia areata from the patient's viewpoint. Forty-five patients conducted measurements of general coping strategies and body image. Qualitative data analysis was performed referring to interviews of stress experiences before the onset of alopecia areata, stress-reactivity, subjective disease models, consequences of alopecia areata and illness-related coping strategies. Patients do not have dysfunction...

Hair shaft abnormalities in alopecia areata evaluated by optical coherence tomography

Skin Research and Technology — Mon, 17 Jan 2011 00:00:00 +0100

Conclusions: The results demonstrate that structural abnormalities of hair shafts are found in active lesions of AA, but not in clinically unaffected hairs. The OCT technique is a promising method to gain more insight into the pathogenesis of AA in a non‐invasive way. (Source: Skin Research and Technology)

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Reflectance Confocal Microscopy of the Yellow Dot Pattern in Alopecia Areata [Observation]

Archives of Dermatology — Mon, 17 Jan 2011 00:00:00 +0100

Conclusion The RCM study of the yellow dot pattern showed a good correlation with the dermoscopic and pathological findings and confirms that the yellow dots correspond to inefficient follicular structures that often contain hair remnants. (Source: Archives of Dermatology)

TRIVAL (Homeopathic Alopecia Areata Treatment) Tincture [TE-Point Doo]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Jan 2011 05:00:00 +0100

Updated Date: Jan 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Successful treatment of resistant alopecia areata with a phototoxic dose of ultraviolet A after topical 8‐methoxypsoralen application

Photodermatology, Photoimmunology and Photomedicine — Tue, 04 Jan 2011 20:47:53 +0100

Conclusion: Phototoxic psoralen and ultraviolet A therapy after topical application of 0.1% 8‐MOP is an effective treatment option for resistant AA, with low total cumulative UVA dose, few treatment sessions, and minimal reversible side effects. (Source: Photodermatology, Photoimmunology and Photomedicine)

Clinical Inquiries: Childhood alopecia areata: What treatment works best?

The Journal of Family Practice — Sat, 01 Jan 2011 00:00:00 +0100

Authors: Haynes JW, Persons R, Jamieson B It's unclear. There are no validated effective treatments for alopecia areata (AA). PMID: 21209981 [PubMed - in process] (Source: The Journal of Family Practice)

Three Cases of Alopecia Following Clinical Islet Transplantation

American Journal of Transplantation — Fri, 31 Dec 2010 08:33:29 +0100

Successful clinical islet allotransplantation requires control of both allo‐ and autoimmunity by using immunosuppressant drugs which have a number of side effects. The development of the autoimmune condition alopecia areata following successful islet transplantation is therefore unexpected. Three cases of alopecia affecting female islet transplant recipients are described. In all cases, alopecia developed approximately 7 years after initial transplant. All had received daclizumab, sirolimus and tacrolimus with their initial transplants, but all were receiving a combination of tacrolimus and mycophenolate mofetil at the time alopecia developed. Two subjects had received thymoglobulin for a subsequent islet infusion and prior to the onset of alopecia. The progression of alopecia has been h...

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Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata

Journal of the European Academy of Dermatology and Venereology — Wed, 29 Dec 2010 00:00:00 +0100

Conclusion Selective downregulation of CD200 in the bulge area could contribute to the collapse of immune privilege with resultant unusual bulge involvement in a subset of AA. (Source: Journal of the European Academy of Dermatology and Venereology)

Trichoscopy for common hair loss diseases: Algorithmic method for diagnosis

The Journal of Dermatology — Thu, 23 Dec 2010 16:02:49 +0100

AbstractIn recent years, the usefulness of trichoscopy (scalp dermoscopy) has been reported for hair loss diseases. Here, characteristic trichoscopic features of common hair loss diseases are described using a DermLite II pro or Epilight eight. Characteristic trichoscopic features of alopecia areata are black dots, tapering hairs (exclamation mark hairs), broken hairs, yellow dots and short vellus hairs. In androgenetic alopecia (AGA), hair diameter diversity (HDD), perifollicular pigmentation/peripilar sign and yellow dots are trichoscopically observed. In all cases of AGA and female AGA, HDD more than 20%, which corresponds to vellus transformation, can be seen. In cicatricial alopecia (CA), the loss of orifices, a hallmark of CA, and the associated changes including perifollicular eryth...

The spectrum of dermatological disorders among primary school children in Dar es Salaam

BMC Public Health - Latest articles — Thu, 16 Dec 2010 00:00:00 +0100

Conclusions: Skin disorders are common in primary school children; infectious dermatoses are still rampant and many children do not seek medical assistance. (Source: BMC Public Health - Latest articles)

Dermoscopic clues to distinguish trichotillomania from patchy alopecia areata

Anais Brasileiros de Dermatologia — Sat, 11 Dec 2010 16:02:33 +0100

CONCLUSIONS: In the case of patchy alopecia and broken hairs, the absence of exclamation mark hairs suggests a diagnosis of trichotillomania. On the other hand, the finding of yellow dots without black dots does not exclude it. (Source: Anais Brasileiros de Dermatologia)

Infliximab: Alopecia areata universalis: case report

Reactions — Tue, 30 Nov 2010 07:20:09 +0100

(Source: Reactions)

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Hypnosis and Alopecia Areata: Long-term Beneficial Effects on Psychological Well-being.

Acta Dermato-Venereologica — Mon, 22 Nov 2010 00:00:00 +0100

Authors: Willemsen R, Haentjens P, Roseeuw D, Vanderlinden J Although there often exists important psychological comorbidity in patients with alopecia areata, few studies have investigated the role of psychotherapeutic interventions. The aim of this prospective cohort study was to investigate the long-term evolution of psychological symptoms in twenty-one patients with refractory alopecia areata. Patients received 10 individual sessions of hypnosis during an approximate 6-month period. Before treatment, patients presented a pathological psychological comorbidity. After treatment, a significant amelioration of alexithymia, anxiety, depression and mental well-being was observed. These improvements were maintained up to 6 months after the end of treatment. Important limitations of this st...

Coexistence of giant blue nevus of the scalp with hair loss and alopecia areata

The Journal of Dermatology — Thu, 11 Nov 2010 00:00:00 +0100

AbstractA 43‐year‐old Japanese man presented with a 13‐year history of a grayish macule measuring 7 cm in diameter with sparse hairs on the vertex. Histopathological examination demonstrated two types of melanocytes, spindle‐shaped and ovoid cells, with abundant melanin aggregated around the upper part of the pilosebaceous apparatus. Fibrous, thick collagen bundles were also seen surrounding the upper part of the small hair follicles. There was no infiltration of melanocytes or lymphocytes in the lower dermis or adipose tissue. Based on these findings, a diagnosis of blue nevus, cellular type, was made. Giant cellular blue nevi on the scalp are rare, and 11 cases reported in the published work have shown characteristic features such as hair loss and cranial invasion of nevus cell...

The Cell Biology of Human Hair follicle Pigmentation

Pigment Cell Research — Wed, 10 Nov 2010 19:28:16 +0100

Abstract:Although we have made significant progress in understanding the regulation of the UVR‐exposed epidermal‐melanin unit, we know relatively little about how human hair follicle pigmentation is regulated. Progress has been hampered by gaps in our knowledge of the hair follicle’s cycle controls, to which hair pigmentation appears tightly coupled. However, pigment cell researchers may have overly focused on the follicular melanocytes of the nocturnal and UVR‐shy mouse as a proxy for human epidermal melanocytes. Here, I emphasise the epidermis‐follicular melanocyte pluralism of human skin, as research models for vitiligo, alopecia areata and melanoma, personal care/cosmetics innovation. Further motivation could be in finding answers to; why hair follicle and epidermal pigmentar...

‘Follicular Swiss cheese’ pattern – another histopathologic clue to alopecia areata

Journal of Cutaneous Pathology — Wed, 10 Nov 2010 00:00:00 +0100

In conclusion, dilated follicular infundibula, reminiscent of a Swiss cheese in horizontally sectioned slides, is an exceedingly useful criterion in the histopathologic diagnosis of alopecia areata and are of great help in the daily routine to recognize alopecia areata.Müller CSL, El Shabrawi‐Caelen L. ‘Follicular Swiss cheese’ pattern – another histopathologic clue to alopecia areata. (Source: Journal of Cutaneous Pathology)

The Cell Biology of Human Hair follicle Pigmentation.

Pigment Cell and Melanoma Research — Wed, 10 Nov 2010 00:00:00 +0100

Authors: Tobin DJ Although we have made significant progress in understanding the regulation of the UVR-exposed epidermal-melanin unit, we know relatively little about how human hair follicle pigmentation is regulated. Progress has been hampered by gaps in our knowledge of the hair follicle's cycle controls, to which hair pigmentation appears tightly coupled. However, pigment cell researchers may have overly focused on the follicular melanocytes of the nocturnal and UVR-shy mouse as a proxy for human epidermal melanocytes. Here, I emphasise the epidermis-follicular melanocyte pluralism of human skin, as research models for vitiligo, alopecia areata and melanoma, personal care/cosmetics innovation. Further motivation could be in finding answers to; why hair follicle and epidermal pigmen...

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Research Technician - Academic Unit of Endocrinology, Diabetes and Metabolism, University of Sheffield

Society for Endocrinology — Tue, 02 Nov 2010 12:00:00 +0100

Added via www.jobs.ac.uk The University of Sheffield has a vacancy for a graduate in a biological science to join a well-established research team looking into autoimmune diseases. The successful applicant will carry out laboratory experiments as directed by the investigators to identify autoantibody targets in alopecia areata, an autoimmune disease characterised by patchy hair loss for which a better understanding of its pathogenesis is required. The deadline for applications is 12 November 2010. For more information please follow the link below. Further details (Source: Society for Endocrinology)

Jean‐Claude Bystryn 1938–2010. An obituary

Experimental Dermatology — Mon, 01 Nov 2010 00:00:00 +0100

Abstract: Jean‐Claude Bystryn, M.D., passed away on 19 August, 2010. Dr. Bystryn’s research interests encompassed a large group of dermatologic conditions. He has earned a worldwide recognition for his innovative works on autoimmune blistering diseases, melanoma and alopecia areata. The most significant impact Dr. Bystryn’s research has made is on our understanding of the mechanisms of epidermal cell detachment (acantholysis) in pemphigus and development of adequate treatment. During the last decade, he chaired the Medical Advisory Board of the International Pemphigus and Pemphigoid Foundation. Dr. Bystryn was an innovative physician‐scientist whose scientific contributions will be long recalled and admired both by patients and colleagues. (Source: Experimental Dermatology)

[Alopecia areata and vitiligo: Can genetics tell us more about their mecanisms?]

Annales de Dermatologie et de Cenereologie — Mon, 01 Nov 2010 00:00:00 +0100

Authors: Dereure O PMID: 21074666 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

The spectrum of hair loss in patients with mycosis fungoides and Sézary syndrome

Journal of the American Academy of Dermatology — Mon, 01 Nov 2010 00:00:00 +0100

Conclusions: Alopecia was observed in 2.5% of patients with MF/SS, with alopecia areata–like patchy loss in 34% and alopecia within MF lesions in 66%. (Source: Journal of the American Academy of Dermatology)

Risk factors for genital lichen sclerosus in men.

The British Journal of Dermatology — Mon, 25 Oct 2010 23:00:00 +0100

Conclusions The results of the present study are in line with the hypothesis that trauma of the penis is a possible trigger of symptoms in genetically predisposed people and that autoimmune disorders in personal and family histories are risk factors for male LS. PMID: 20973765 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Hair follicle is a target of stress hormone and autoimmune reactions

Journal of Dermatological Science — Tue, 12 Oct 2010 23:00:00 +0100

This article reviews the interaction between the endocrine/immune system and HFs, including the pathogenesis of alopecia areata associated with stress. (Source: Journal of Dermatological Science)

Alopecia areata: Study reveals genetic clues

Modern Medicine — Thu, 30 Sep 2010 23:00:00 +0100

Recent published findings of a Genome Wide Association Study (GWAS) for alopecia areata (AA) have pinpointed at least eight genes linked to the disease. (Source: Modern Medicine)

Patients with profuse hair shedding may reveal anagen hair dystrophy: a diagnostic clue of alopecia areata incognita

Journal of the European Academy of Dermatology and Venereology — Thu, 30 Sep 2010 23:00:00 +0100

Abstract (Source: Journal of the European Academy of Dermatology and Venereology)

Alopecia areata universalis during off-label treatment with Infliximab in a patient with BehÃ§et disease.

Dermatol Online J — Thu, 30 Sep 2010 16:35:04 +0100

We describe a case of alopecia areata universalis associated with infliximab treatment in a patient with BehÃ§et disease. This case suggests a complex and contradictory role of TNF-Î± in the pathogenesis of alopecia areata. PMID: 20875336 [PubMed - in process] (Source: Dermatol Online J)

An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata

Medical Hypotheses — Thu, 30 Sep 2010 00:00:00 +0100

Summary: Alopecia areata (AA) is a hair follicle-specific autoimmune disease that is inherited genetically but triggered environmentally. Stress response is believed to play a role in the pathogenesis of AA. The hypothalamic–pituitary–adrenal axis (HPA axis), known as the stress axis, plays a cardinal role in the stress response. Growing evidence demonstrates that stress responses are under the control of both the central and peripheral nervous systems. Skin and hair follicles display peripheral HPA axis-like signaling systems. Some studies have revealed that a modified HPA axis, which is characterized by enhanced CRH/CRHR and insufficient glucocorticoid, is involved in the pathology of AA, suggesting that the paradoxical expression differs from that of normal control and should be fur...

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Could azathioprine be considered as a therapeutic alternative in the treatment of alopecia areata? A pilot study

International Journal of Dermatology — Wed, 29 Sep 2010 13:35:48 +0100

Abstract (Source: International Journal of Dermatology)

Infliximab: Psoriasiform eruption and alopecia areata in an elderly patient: case report

Reactions — Tue, 21 Sep 2010 07:09:46 +0100

(Source: Reactions)

Treatment of alopecia areata with 308‐nm excimer lamp

The Journal of Dermatology — Tue, 31 Aug 2010 23:00:00 +0100

Abstract (Source: The Journal of Dermatology)

CASE REPORT: Hair transplantation for therapy‐resistant alopecia areata of the eyebrows: Is it the right choice?

The Journal of Dermatology — Fri, 27 Aug 2010 05:41:29 +0100

Abstract (Source: The Journal of Dermatology)

Trichohyalin is a Potential Major Autoantigen in Human Alopecia Areata

Journal of Proteome Research — Thu, 19 Aug 2010 14:16:43 +0100

Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)

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Functional polymorphisms of the FAS/FASLG genes are associated with risk of alopecia areata in a Chinese population: a case–control analysis

British Journal of Dermatology — Sat, 31 Jul 2010 23:00:00 +0100

Summary (Source: British Journal of Dermatology)

An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?

Experimental Dermatology — Sat, 31 Jul 2010 23:00:00 +0100

Please cite this paper as: (Source: Experimental Dermatology)

Evaluation of free oxygen radical and antioxidant capacity in alopecia areata

The Journal of Dermatology — Sat, 31 Jul 2010 23:00:00 +0100

(Source: The Journal of Dermatology)

[Treatment of alopecia areata with prednisone in a once-monthly oral pulse.]

Annales de Dermatologie et de Cenereologie — Sat, 31 Jul 2010 23:00:00 +0100

CONCLUSION: A once-monthly oral pulse of 300mg prednisone appears effective and safe. It can be recommended as first-line treatment for widespread AA. PMID: 20804894 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

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[Long-term follow-up of the efficacy of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia areata totalis or universalis.]

Annales de Dermatologie et de Cenereologie — Sat, 31 Jul 2010 23:00:00 +0100

CONCLUSION: MTX alone or in combination with low doses of oral corticosteroids resulted in complete hair regrowth in about half of these patients presenting AA totalis or universalis. Lasting improvement required continuous treatment in most cases. PMID: 20804893 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

Clinical review: Management of alopecia areata

NeLM - News — Sun, 25 Jul 2010 23:00:00 +0100

Source: British Medical Journal Area: News This clinical review article discusses the management of alopecia areata, a common condition (estimated lifetime risk of 1.7%) characterised by patchy hair loss without signs of skin inflammation or scarring. The course is unpredictable and spontaneous re-growth can occur at any time; in over half of cases with patchy disease this will be seen within one year. It is difficult to manage and most therapeutic options are unsatisfactory; objective assessment of the efficacy of treatments is difficult due to the high rate of spontaneous remission. The following issues are discussed: . Who gets alopecia areata? . What are the characteristic clinical features of alopecia areata and how is it classified? . ...

Management of alopecia areata

BMJ Online First — Fri, 23 Jul 2010 10:26:33 +0100

(Source: BMJ Online First)

Folliculotropic mycosis fungoides masquerading as alopecia areata

Journal of the American Academy of Dermatology — Thu, 15 Jul 2010 06:22:20 +0100

To the Editor: Early in 2004, a 27-year-old male presented to our department with a 2-year history of progressive patchy alopecia of the left side of the pubis and upper thigh without signs of inflammation (, A). (Source: Journal of the American Academy of Dermatology)

Lipid peroxidation/antioxidant activity in patients with alopecia areata

Journal of the European Academy of Dermatology and Venereology — Tue, 13 Jul 2010 23:00:00 +0100

Conclusions Increased lipid peroxidation and defective SOD activity exist in patients with AA. Addition of drugs with antioxidative effects seems to be valuable in treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

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Innate and adaptive immunity genes implicated in alopecia areata

MedWire News - Dermatology — Fri, 09 Jul 2010 00:00:00 +0100

Results from a genome-wide association study show an association between genes involved in innate and adaptive immunity and susceptibility to alopecia areata. (Source: MedWire News - Dermatology)

Alopecia areata in Eringer cows.

Veterinary Dermatology — Wed, 07 Jul 2010 23:00:00 +0100

Authors: Timm K, RÃ¼fenacht S, von Tscharner C, Bornand VF, Doherr MG, Oevermann A, Flury C, Rieder S, Hirsbrunner G, DrÃ¶gemÃ¼ller C, Roosje PJ Abstract Alopecia areata is a hair loss disorder in humans, dogs and horses with a suspected autoimmune aetiology targeting anagen hair follicles. Alopecia areata is only sporadically reported in cows. Recently, we observed several cases of suspected alopecia areata in Eringer cows. The aim of this study was to confirm the presumptive diagnosis of alopecia areata and to define the clinical phenotype and histopathological patterns, including characterization of the infiltrating inflammatory cells. Twenty Eringer cows with alopecia and 11 Eringer cows without skin problems were included in this study. Affected cows had either generalized o...

Patient Voices: A ‘Forest Fire of Hair Loss,’ and Its Scars

NYT Health — Tue, 06 Jul 2010 01:59:02 +0100

In facing alopecia areata, Matt Kelley slowly regained his sense of self. (Source: NYT Health)

Patient Voices: A ‘Forest Fire of Hair Loss’ and Its Emotional Scars

NYT Health — Mon, 05 Jul 2010 20:38:16 +0100

In facing alopecia areata, a disease with no universally effective treatment, Matt Kelley joined a support group and slowly regained his sense of self. (Source: NYT Health)

New Study Implicates Autoimmune Mechanisms in Alopecia Areata

Medscape Today Headlines — Fri, 02 Jul 2010 18:23:44 +0100

Hair-loss disease has risk loci in common with many other autoimmune diseases. Medscape Medical News (Source: Medscape Today Headlines)

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Genetic Basis Of Alopecia Areata Established - May Soon Lead To New Treatments For Hair Loss Sufferers

Health News from Medical News Today — Fri, 02 Jul 2010 07:00:00 +0100

A team of investigators led by Columbia University Medical Center has uncovered eight genes that underpin alopecia areata, one of the most common causes of hair loss, as reported in a paper in the July 1, 2010 issue of Nature. Since many of the genes are also implicated in other autoimmune diseases, including rheumatoid arthritis and type 1 diabetes - and treatments have already been developed that target these genes - this discovery may soon lead to new treatments for the 5.3 million Americans suffering from hair loss caused by alopecia areata... (Source: Health News from Medical News Today)

Acclaimed Geneticist Finds Basis Of Alopecia Areata

Health News from Medical News Today — Thu, 01 Jul 2010 09:00:00 +0100

On July 1, 2010, Nature Journal, the weekly, international, interdisciplinary journal of science, published an article that unveils the most exciting genetic research on alopecia areata to date. Led by the National Alopecia Areata Foundation Scientific Advisory Council member Dr. Angela Christiano, and using cases from the National Alopecia Areata Registry, a team of investigators from Columbia University Medical Center have found eight genes that contribute to alopecia areata, one of which has a possible role in the onset of the disease... (Source: Health News from Medical News Today)

Genetic basis of alopecia areata -- one of most common causes of hair loss

ScienceDaily Headlines — Thu, 01 Jul 2010 07:15:49 +0100

Researchers have uncovered eight genes that underpin alopecia areata, one of the most common causes of hair loss. Since many of the genes are also implicated in other autoimmune diseases, including rheumatoid arthritis and type 1 diabetes, this discovery may soon lead to new treatments for the 5.3 million Americans suffering from hair loss caused by alopecia areata. (Source: ScienceDaily Headlines)

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

Nature — Thu, 01 Jul 2010 06:43:44 +0100

This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. (Source: Nature)