MedWorm: Alopecia

Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren's syndrome

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Muscle and Nerve)

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Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

British Journal of Dermatology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: The observed association suggests that the AR/EDA2R locus confers susceptibility to early onset FHPL. Our results do no implicate the 20p11 locus in the aetiology of FPHL. (Source: British Journal of Dermatology)

Effect of petroleum ether and ethanol fractions of seeds of Abrus precatorius on androgenic alopecia

Revista Brasileira de Farmacognosia — Sun, 05 Feb 2012 18:30:49 +0100

Seeds of Abrus precatorius L., Fabaceae, are commonly used as purgative, emetic, aphrodisiac and in nervous disorder in traditional and folk medicines. In present study petroleum ether and ethanolic extracts of A. precatorius seeds are evaluated for reversal of androgen (testosterone by i.m route) induced alopecia in male albino wistar rats and compared to topical administration of standard antiandrogenic drug finasteride for 21 days. The results were reflected from visual observation and histological study of several skin sections via various parameters as anagen to telogen ratio and follicle density/mm area of skin surface. The animal of group 1 who were treated with only testosterone became alopecic on visual observation. Animals of Group 2, 3 and 4 who were treated with finasteride, pe...

DIY science: should you try this at home?

Guardian Unlimited Science — Fri, 03 Feb 2012 22:59:00 +0100

When Richard Handl was arrested for attempting to split the atom on his stove, he joined a growing band of home experimenters cooking up all kinds of trouble behind the kitchen doorÄngelholm is a pretty southern Swedish town, famed for its clay cuckoo manufacturing, a clay cuckoo being a kind of ocarina, which is a kind of flute. The crime rate here is practically zero. Except one of its residents was last year arrested for trying to split the atom in his kitchen. His name is Richard Handl and he buzzes me into his first-floor flat.I wanted to meet Richard because I keep seeing reports of home science experimenters clashing with the authorities. There's been a spate of them this past year or two.I glance into Richard's kitchen and recognise his cooker from the news. It was horrendously, a...

Successful calvarial bone salvage using multiple outer table perforation technique on total scalp avulsion injury

European Journal of Plastic Surgery — Fri, 03 Feb 2012 17:12:39 +0100

We report a case of extensive scalp avulsion with a large area of bone devoid of its periosteum. Outer calvarial plate perforations were drilled to promote granulation tissue growth. Skin grafts were used as a temporary coverage. The remaining scalp was then expanded, and the flaps obtained allowed a satisfactory coverage of the area of alopecia. The objective of this report is to bring this treatment method again into the set of possibilities to be considered when planning scalp reconstruction, as it is a feasible alternative and enables good results. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s00238-012-0691-5Authors Davi Reis Calderoni, Division of Plastic Surgery, Department of Surgery, Campinas State University—Unicamp Medical Center, Rua Tessál...

Pityriasis amiantacea: a distinctive presentation of psoriasis associated with tumour necrosis factor‐α inhibitor therapy

Clinical And Experimental Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

We present a case of PA as a complication of underlying psoriasis, which developed during tumour necrosis factor (TNF)‐α inhibitor therapy for Crohn disease. This paradoxical cutaneous reaction to anti‐TNF‐α threapy has been recently described as an emerging and perplexing cause of psoriasis and psoriasiform eruptions. (Source: Clinical And Experimental Dermatology)

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6 Year Old Cuts Her Mother's Hair to Prepare for Chemo

About.com Cancer — Tue, 31 Jan 2012 05:00:00 +0100

Chemotherapy induced hair loss can be an emotionally devastating side effect of treatment. You never quite realize how much your hair means to you until you don't have it. If you are a parent, you may realize how much your hair means to them, too. Often silently, children are bothered by the sudden loss of a parent's hair. To them, hair loss can be a physical reminder that their parent is sick....Read Full Post (Source: About.com Cancer)

Alopecia Areata during Treatment of Psoriasis with Adalimumab and Leflunomide: A Case and Review of the Literature

Skin Pharmacology and Physiology — Mon, 30 Jan 2012 23:00:00 +0100

Skin Pharmacol Physiol 2012;25:107–110 (DOI:10.1159/000335264) (Source: Skin Pharmacology and Physiology)

Hair follicle stem cell differentiation is inhibited through a cross talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

British Journal of Dermatology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusions: These results suggest that androgens deregulate DPC‐secreted factors involved in normal HF stem cell differentiation via the inhibition of the canonical Wnt signalling pathway. (Source: British Journal of Dermatology)

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis

International Journal of Photoenergy — Tue, 24 Jan 2012 18:18:57 +0100

CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, dermatomyositis, primary biliary cirrhosis, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo, bullous pemphigoid, alopecia areata, idiopathic dilated cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis, IgA nephropathy, membranous nephropathy, and pernicious anaemia. It also occurs in healthy blood relatives of patients with autoimmune diseases, suggesting it is genetically determined. Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune dise...

Hair loss, nail changes, GI symptoms – think selenium toxicity

The Poison Review — Tue, 24 Jan 2012 06:01:39 +0100

4 out of 5 stars Case Series of Selenium Toxicity From A Nutritional Supplement. Aldosary BM et al. Clin Toxicol 2012;50:57-64. Abstract This case series describes9 patient who developed selenium toxicity after ingesting a nutritional supplement that contained 200 times the recommend concentration of selenium. Patients presented with signs and symptoms characteristic of selenium toxicity: alopecia, dystrophic fingernail changes, gastrointestinal symptoms, and memory deficits. All symptoms resolve when exposure to selenium was terminated. Selenium is an essential trace element that can be harmful when taken in excess. the precise toxic mechanism is not known. Another toxic cause of alopecia is thallium. For more on excess in selenium in dietary supplements, see this release from the CDCP. ...

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Induction chemotherapy followed by concomitant radiotherapy and weekly cisplatin versus the same concomitant chemoradiotherapy in patients with nasopharyngeal carcinoma: a randomized phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: IC with three cycles of CEP when followed by CCRT did not significantly improve response rates and/or survival compared with that of CCRT alone. (Source: Annals of Oncology)

A comment regarding ‘follicular Swiss cheese’ in the diagnosis of alopecia areata

Journal of Cutaneous Pathology — Sat, 21 Jan 2012 04:54:02 +0100

(Source: Journal of Cutaneous Pathology)

The ‘Tyler technique’ for alopecia biopsies

Journal of Cutaneous Pathology — Sat, 21 Jan 2012 04:54:00 +0100

(Source: Journal of Cutaneous Pathology)

The management of EGFR inhibitor adverse events: a case series and treatment paradigm.

Herpes — Fri, 20 Jan 2012 03:31:03 +0100

Conclusion The most common cutaneous adverse event in our cohort was papulopustular rash, followed by eczema and xerosis. Patients were managed with symptom target therapy, and suspension of the EGFR inhibitor was rarely required. As the use of EGFR inhibitors increases, it is important to promptly identify and treat adverse events. Further studies are necessary to develop targeted therapeutic and preventative measures. PMID: 22250636 [PubMed - in process] (Source: Herpes)

Are medical communities the new marketing demographic?

Thrive, Children's Hospital Boston — Thu, 19 Jan 2012 13:48:19 +0100

Have you heard about the bald Barbie movement? It’s a grassroots, digital campaign asking Mattel to make a version of the doll without her trademark golden locks to benefit children with illness. According to the group’s Facebook page, which has gained more than 130,000 fans in less than a month, bald Barbie would let “children suffering cancer, alopecia and any other illness that causes them to lose their hair, feel just as beautiful as the dolls they play with.” Regardless of how people feel about the plastic fashion icon—she’s been around for more than half a century but still seems to be a very polarizing figure; often because of her figure—the online support for bald Barbie is undeniable. Many people seem ready to overlook any issues they may have had...

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The management of EGFR inhibitor adverse events: a case series and treatment paradigm

International Journal of Dermatology — Tue, 17 Jan 2012 17:44:18 +0100

Treatment of folliculitis decalvans with tacrolimus ointment

International Journal of Dermatology — Tue, 17 Jan 2012 17:44:08 +0100

AbstractFolliculitis decalvans is an embarrassing and challenging disease with no established treatment guidelines. In this paper, we described four patients with this disease treated successfully with Tacrolimus ointment. All of them showed significant control of the condition, stopping inflammatory lesions and progression of the disease, although weak transitory outbreaks of inflammatory lesions were observed in some cases. Alopecia and tufted hairs remained unchanged. The discontinuation of the therapy produced rapid relapses in all cases. Close monitoring of these patients is recommended due to the potential risk of malignant transformation of the disease. (Source: International Journal of Dermatology)

Polarized Microscopy as a Helpful Tool to Distinguish Chronic Nonscarring Alopecia From Scarring Alopecia [Observation]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

Conclusion Polarized light can be used in the pathological evaluation of hair loss to distinguish between the follicular scars in scarring alopecia and the fibrovascular streamers in long-standing nonscarring alopecia. (Source: Archives of Dermatology)

Long-term membranous glomerulonephritis as the presenting manifestation of systemic lupus erythematosus in a patient with human immunodeficiency virus infection.

Lupus — Mon, 16 Jan 2012 05:00:00 +0100

We present the case of a 45-year-old Hispanic woman with long-standing HIV infection who developed membranous glomerulonephritis with histological features of lupus nephritis. Five years after onset of renal disease she developed clinically evident SLE. PMID: 22249649 [PubMed - as supplied by publisher] (Source: Lupus)

Psychosocial impact of cicatricial alopecias

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion: The management of cicatricial alopecias needs a holistic approach. In addition to laying an emphasis on early diagnosis aided by clinco-pathological correlation, to prevent irreversible hair loss, the psychosocial impact of the disease should also be taken into consideration and addressed by the treating dermatologist. (Source: Indian Journal of Dermatology)

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Oral doxycycline with topical tacrolimus for treatment of stasis dermatitis due to chronic venous insufficiency: A pilot study

Indian Journal of Pharmacology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion: This pilot study suggests efficacy of this combination therapy in controlling features of stasis dermatitis but further studies are needed for validation. (Source: Indian Journal of Pharmacology)

Evaluation of Efficacy and Safety of Bevacizumab Combined with Chemotherapy  for Chinese Patients with Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer — Fri, 13 Jan 2012 13:20:50 +0100

Conclusion Bevacizumab combined with carboplatin-based chemotherapy may be well tolerated and beneficial for Chinese patients with non-squamous NSCLC. DOI: 10.3779/j.issn.1009-3419.2012.01.02 (Source: Chinese Journal of Lung Cancer)

Effects of Hura crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation.

Biological and Pharmaceutical Bulletin — Fri, 13 Jan 2012 09:48:02 +0100

Authors: Uchiyama C, Ishida K, Tsutsui T, Naito A, Kurita K, Hanihara H, Serizawa T, Fujiwara M, Ohdera M Abstract Neurotrophin (NT)-4 is known to be an inducer of catagen in the hair cycle, but little is known of its role in the pathogenesis of androgenetic alopecia (AGA). We previously studied the gene expression of dermal papilla cells from AGA patients and controls and found that NT-4 was up-regulated in the AGA patients. In the present study, the etiological relationship between NT-4 and androgen, which is one of the causes of AGA, and the effect of an NT-4 inhibitor on hair growth were investigated. We established a NT-4 luciferase reporter assay system using a roughly 2-kb region upstream of the NT-4 transcriptional start site and investigated an accelerating effect of andro...

Whorled hairless nevus of the scalp, linear hyperpigmentation, and telangiectatic nevi of the lower limbs: A novel variant of the “phacomatosis complex”

American Journal of Medical Genetics Part A — Fri, 13 Jan 2012 05:00:00 +0100

We report on an 8‐year‐old boy with striking right hemihypoplasia, resulting in limb asymmetry and fixed dislocation of right hip. Skin on the affected side showed three distinct nevi: (i) A whorled, hairless nevus of the scalp in close proximity with (ii) epidermal hyperpigmentation following lines of Blaschko on the neck and right upper limb, and (iii) multiple telangiectatic nevi of the right lower limb and hemiscrotum. Didymosis atricho‐melanotica was proposed for the combination of adjacent patchy congenital alopecia and linear hyperpigmentation, while phacomatosis atricho‐pigmento‐vascularis appears to define the entire cutaneous phenotype, thus implying the involvement of three neighboring loci influencing the development of distinct constituents of the skin. Given the str...

Olivia Rusk is your average teenager, just bald

USATODAY.com Health — Thu, 12 Jan 2012 16:39:27 +0100

She speaks out about her condition, alopecia, and bullying. (Source: USATODAY.com Health)

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Barbie Considers A No-Hair Day To Help Cancer Survivors

About.com Breast Cancer — Thu, 12 Jan 2012 05:00:00 +0100

Bald Barbie Art © Pam Stephan Barbie has been around since 1959 but she has yet to develop any sags, bags, or wrinkles. Indeed, no matter what time or what day it is, Barbie always looks flawless, confident, and ready to handle anything. Now a group on FaceBook is asking Barbie to think of going bald - in order to help out girls who have suffered from hair loss due to cancer treatments. The group also sees the bald beauty as a coping aid for children whose mothers have lost their own hair to chemotherapy....Read Full Post (Source: About.com Breast Cancer)

Olivia Rusk is your average teenager -- just bald

USATODAY.com Health — Wed, 11 Jan 2012 22:52:53 +0100

She speaks out about her condition, alopecia, and bullying. (Source: USATODAY.com Health)

Friends connected by cancer campaign for bald Barbie

Health News: CBSNews.com — Wed, 11 Jan 2012 22:47:27 +0100

Two women start Facebook group asking Mattel for bald Barbie to raise awareness for cancer and other hair loss diseases (Source: Health News: CBSNews.com)

Cancer survivors petition online for bald Barbie

Health News: CBSNews.com — Wed, 11 Jan 2012 22:08:16 +0100

Two friends started a Facebook campaign for Mattel to make a bald Barbie for cancer and hair loss survivors (Source: Health News: CBSNews.com)

Nemo syndrome (incontinentia pigmenti) and systemic lupus erythematosus: a new disease association.

Lupus — Tue, 10 Jan 2012 05:00:00 +0100

This report may suggest a role for NF-kB essential modulator in the pathogenesis of SLE, in the context of thecomplex immunologic deficiencies increasingly associated with autoimmune diseases. PMID: 22235006 [PubMed - as supplied by publisher] (Source: Lupus)

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Frontal Fibrosing Alopecia in black patients.

The British Journal of Dermatology — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Miteva M, Whiting D, Harries M, Bernardes A, Tosti A PMID: 22229387 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Frontal Fibrosing Alopecia in black patients

British Journal of Dermatology — Mon, 09 Jan 2012 05:00:00 +0100

(Source: British Journal of Dermatology)

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα

Investigational New Drugs — Fri, 06 Jan 2012 16:48:06 +0100

In conclusion, 5F is effective against HCC with minimal side effects. It induces apoptosis in HCC cells via inhibiting NF-kB, leading to the decrease of Bcl-2 but the increase of Bax and Bak. Content Type Journal ArticleCategory PRECLINICAL STUDIESPages 1-9DOI 10.1007/s10637-011-9791-5Authors George G. Chen, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongJackie Leung, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongNian Ci Liang, Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong, ChinaLi Li, Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong, Chin...

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata

Journal of the European Academy of Dermatology and Venereology — Fri, 06 Jan 2012 05:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Conventional transarterial chemoembolisation in combination with sorafenib for patients with hepatocellular carcinoma: a pilot study

European Radiology — Wed, 04 Jan 2012 07:00:56 +0100

Conclusion These findings do not support use of an intensive, high-dose doxorubicin-based TACE regimen in combination with sorafenib in this study population. Key Points • Transarterial chemoembolisation (TACE) is widely used in patients with hepatocellular carcinoma (HCC) • Various antiangiogenic and other agents have been used to augment this treatment • We tested lipiodol-TACE with bilirubin-adjusted doxorubicin dosing in combination with sorafenib • This trial was stopped prematurely because of safety reasons • Our safety results do not support the combination of sorafenib with this TACE regimen Content Type Journal ArticleCategory Hepatobiliary-PancreasPages 1-10DOI 10.1007/s00330-011-2368-zAuthor...

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Lipedematous diseases of the scalp are not separate entities but part of a spectrum of lipomatous lesions

JDDG — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Due to the possibility of excluding therapeutic elements by separating the lipomatous lesions into various entities, we propose using the term “localized lipomatosis of the scalp with or without associated alopecia” in order to arrive at a straightforward diagnosis, thereby avoiding numerous partially synonymous terms; moreover, we do not intend to expand the spectrum of distinct lipomatous entities, but propose classification of these diseases within the group of conventional lipomatosis. (Source: JDDG)

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Journal of Pediatric Surgery — Sun, 01 Jan 2012 05:00:00 +0100

Self-filling, hydrogel-based osmotic tissue expanders have been successfully used for several years mainly in adult patients. The authors tested this novel device in pediatric plastic and reconstructive surgery. Fifty-three osmotic expanders were implanted following standard surgical principles in a total of 30 children and adolescents with burn scars, congenital nevi, alopecia, and foot deformities. All expanders reached their predicted volume within 6 weeks, and 51 (96.2%) produced a sufficient amount of additional skin for the intended coverage of the defect. (Source: Journal of Pediatric Surgery)

Alopecia areata associated with haloperidol decanoate long-acting injection.

The Australian and New Zealand Journal of Psychiatry — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Bhattacharya A, Roy D, Hazarika S, Das S, Nath K, Saddichha S PMID: 22247099 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)

Advances in the management of alopecia areata

The Journal of Dermatology — Sat, 31 Dec 2011 05:47:39 +0100

AbstractSpontaneous remission occurs in up to 80% of patients with limited patchy alopecia areata (AA) within 1 year. Therefore, not all patients of AA simplex/multiplex need extensive treatments, and “wait and see” is one of the choices for some patients. However, once the hair loss show progressive course, it is really difficult to manage well and may be recalcitrant to any treatment in some cases. Hair loss symptom is not life‐threatening but severely decreases quality of life. There have been two widely known guidelines for AA from the British Association of Dermatologists and the National Alopecia Areata Foundation (USA). These guidelines have been substantial and provide clues for dermatologists but needed to be updated. Recently, the Japanese Dermatological Association also ...

Hair biology and hair loss disorders: An update and new concepts

The Journal of Dermatology — Sat, 31 Dec 2011 05:47:36 +0100

(Source: The Journal of Dermatology)

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Behind the Headlines quiz of the year 2011

NHS News Feed — Fri, 30 Dec 2011 15:59:00 +0100

It's been a year in which great scientific minds have addressed many burning questions, asking – among many, many other things – should nuns take the Pill, is watching television bad for your heart, do hammocks aid sleep, and can a shed make a man healthy. In 2011 Behind the Headlines has covered more than 500 health stories that made it into the mainstream media. Just for fun, test your knowledge of the year with our month-by-month quiz. Answers are at the foot of the page. January Researchers in the US and Taiwan claimed faulty stem cells caused what? a) Vitamin B deficiency b) Baldness c) Memory loss February A systematic review of studies with more than a million participants concluded that heart disease risk was reduced by moderate intake of what? a) Aspirin b) Vitamin D c) Al...

Intractable Diffuse Alopecia Caused by Multifactorial Side‐Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion

Pediatric Dermatology — Fri, 30 Dec 2011 05:00:00 +0100

We report the case of a 22‐year‐old girl with a genetic predisposition to pattern hair loss who developed inveterate diffuse alopecia. The patient had onset of ALL at 8 years old and underwent bone marrow transplantation (BMT). Diffuse alopecia gradually advanced over her whole body. Her vellus scalp hair gradually came out, and hair loss progressed again at 8 years, after BMT. She later developed iatrogenic failure of secretion of estrogen and was treated with estrogen substitution therapy for 14 months from the age of 20. There was a small increase in the volume of hair during therapy, but alopecia returned to the former level after the therapy was suspended. Histopathologic examinations of the scalp performed during estrogen substitution therapy and 2 years after suspension ...

Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity.

Journal of Immunology — Fri, 30 Dec 2011 05:00:00 +0100

Authors: Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM Abstract Autoimmune alopecia is characterized by an extensive epidermal T cell infiltrate that mediates hair follicle destruction. We have investigated the role of cell adhesion molecule 1 (Cadm1; Necl2) in this disease. Cadm1 is expressed by epidermal cells and mediates heterotypic adhesion to lymphocytes expressing class 1-restricted T cell-associated molecule (CRTAM). Using a murine autoimmune alopecia model, we observed an increase in early-activated cytotoxic (CD8-restricted, CRTAM-expressing) T cells, which preferentially associated with hair follicle keratinocytes expressing Cadm1. Coculture with Cadm1-transduced MHC-matched APCs stimulated alopecic lymph node cells to release IL-2 and IFN-γ. Overexpression of Cadm...

Alopecia Areata, Comorbidities, and Age of OnsetAlopecia Areata, Comorbidities, and Age of Onset

Medscape Today Headlines — Thu, 29 Dec 2011 16:27:26 +0100

Is there a link between age of onset and comorbidities in patients with alopecia areata? Medscape Dermatology (Source: Medscape Today Headlines)

Avoidance of overheating and selection for both hair loss and bipedality in hominins [Anthropology]

Proceedings of the National Academy of Sciences — Tue, 27 Dec 2011 05:00:00 +0100

Two frequently debated aspects of hominin evolution are the development of upright bipedal stance and reduction in body hair. It has long been argued, on the basis of heat-balance models, that thermoregulation might have been important in the evolution of both of these traits. Previous models were based on a stationary individual standing in direct sunlight; here we extend this approach to consider a walking hominin, having argued that walking is more thermally challenging than remaining still. Further, stationary activities may be more compatible with shade seeking than activities (such as foraging) involving travel across the landscape. Our model predictions suggest that upright stance probably evolved for nonthermoregulatory reasons. However, the thermoregulatory explanation for hair lo...

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Menopausal-type symptoms among breast cancer patients on aromatase inhibitor therapy.

Climacteric — Fri, 23 Dec 2011 05:00:00 +0100

Conclusions Because bothersome symptoms and side-effects are a major reason for discontinuation and non-adherence to treatment, symptoms should be monitored and addressed by oncologists so that the breast cancer patient can maintain her quality of life and remain adherent to the treatment schedule. PMID: 22191462 [PubMed - as supplied by publisher] (Source: Climacteric)

[Soft tissue reconstruction with a temporoparietal fascial flap (TPFF).]

Operative Orthopadie und Traumatologie — Fri, 23 Dec 2011 05:00:00 +0100

Authors: Koulaxouzidis G, Torio-Padron N, Momeni A, Lampert F, Zajonc H, Bannasch H, Björn Stark G Abstract OBJECTIVE: Soft tissue reconstruction with a temporoparietal fascial flap (TPFF). INDICATIONS: Defect coverage with thin, pliable, and well-vascularized tissue. A bilayered TPFF provides a gliding surface in tendon reconstruction. Further options include TPFF harvest with overlying skin or subjacent bone for composite tissue reconstruction or the application as a sensate local fascial flap. Maximum defect dimensions: 17 × 14 cm. CONTRAINDICATIONS: Absolute: prior injury to the flap or flap pedicle, temporal arteritis, Moyamoya syndrome, defects with volume deficit. Relative: alopecia alo...

A case of alopecia universalis with agminated lentiginosis and multiple café‐au‐lait macules: a synchronous coincidence?

International Journal of Dermatology — Thu, 22 Dec 2011 05:56:40 +0100

(Source: International Journal of Dermatology)

Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3-hydroxyisovaleric acid in valproate-treated patients

Journal of Inherited Metabolic Disease — Wed, 21 Dec 2011 20:06:49 +0100

Discussion Our results suggest the interference of VPA with the activity of 3MCC through a potential cumulative effect: direct inhibition of the enzyme activity by the drug metabolite valproyl-CoA and the inhibition of biotinidase by valproate and/or its metabolites. These interactions may be associated with the skin rash and hair loss which are side effects often reported in VPA-treated patients. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10545-011-9423-4Authors Paula B. M. Luís, Research Institute for Medicines and Pharmaceutical Sciences, iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, PortugalJos P. Ruiter, Department of Clinical Chemistry and Pediatrics, Academic Medical Center, Amsterdam, Meibergdreef 9, 110...

Temsirolimus in combination with carboplatin and paclitaxel in patients with advanced solid tumors: a NCIC-CTG, phase I, open-label dose-escalation study (IND 179)

Annals of Oncology — Tue, 20 Dec 2011 05:00:00 +0100

Conclusion: Carboplatin–paclitaxel–temsirolimus is well tolerated and the RPTD is carboplatin area under the curve 5 mg/ml/min, paclitaxel 175 mg/m2, both given on day 1 with temsirolimus 25 mg on days 1 and 8. (Source: Annals of Oncology)

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Association of discoid lupus with clinical manifestations and damage accrual in profile: A multiethnic lupus cohort

Arthritis Care and Research — Tue, 20 Dec 2011 05:00:00 +0100

Conclusion.In this cohort of SLE patients, discoid lupus was associated with several clinical features including serious manifestations such as vasculitis and chronic seizures. © 2011 American College of Rheumatology. (Source: Arthritis Care and Research)

[Dermatofibrosarcoma protuberans in children.]

Annales de Chirurgie Plastique et Esthetique — Tue, 20 Dec 2011 05:00:00 +0100

Authors: Abdel Wahab O, Qassemyar A, Maillet M, Mortier L, Martin de la Salle E, Guerreschi P Abstract Dermatofibrosarcoma protuberans is a malignant and locally invasive tumor. It generally affects young adults. However, in rare but not exceptional cases, children can suffer from this disease. In the literature, there are only few studies on this pathology occurring in children. The main treatment is surgical excision with large margins. We studied in our series 15 cases of dermatofibrosarcoma in children between 1995 and 2008. The data were retrospectively collected. The aim of our study is to underline the best support for this pathology in children. The mean age at the moment of diagnosis was 13years old. None of our patients underwent surgery for dermatofibrosarcoma removal be...

Interferon alpha for chronic hepatitis D.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: Interferon alpha does not seem to cure hepatitis D in most patients. The agent seems effective in suppressing viral and liver disease activity in some patients, but this improvement is not sustained in the majority of patients. We cannot exclude overestimation of benefits and underestimation of harms due to high risk of bias (systematic errors) and high risk play of chance (random errors). Therefore, more randomised trials with large sample sizes and less risk of bias are needed before interferon can be recommended or refuted. PMID: 22161394 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients

European Journal of Clinical Pharmacology — Mon, 19 Dec 2011 16:53:07 +0100

Conclusions A generalized estimating equation model analysis showed that alopecia and hyperlipidemia were associated with dose-adjusted level of tacrolimus (p < 0.001). Genotype of CYP3A5 variants along with significant clinical covariates may be useful in individualizing tacrolimus therapy in kidney transplantation patients. Content Type Journal ArticleCategory PharmacogeneticsPages 1-13DOI 10.1007/s00228-011-1182-5Authors In-Wha Kim, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 KoreaYoo Jin Moon, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 KoreaEunhee Ji, College of Pharmacy ...

Assessment of hair density and caliber in Caucasian and Asian female subjects with female pattern hair loss by using the Folliscope

Journal of the American Academy of Dermatology — Mon, 19 Dec 2011 05:52:16 +0100

To the Editor: Clinical experience and past studies have suggested that Caucasian scalp hair is more dense than Asian hair, but at the same time the terminal hair fibers are thinner in average diameter. However, most of these studies were done on a single ethnic group and did not involve a direct comparison between races within the study. (Source: Journal of the American Academy of Dermatology)

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Hair transplantation

Journal of the American Academy of Dermatology — Mon, 19 Dec 2011 05:52:16 +0100

As a physician who has been performing hair transplantation for 23 years, having first started with 4.5-mm plugs, taught by my mentor—who in turn was taught by Dr Norman Orentreich—and whose technique evolved through the years to what is now considered current technology with follicular unit transplantation, I greatly enjoyed reading Hair Transplantation by Drs Avram and Rogers. The field of hair transplantation has been missing a concise reference text, and Hair Transplantation fills that void. Hair Transplantation is a “soup to nuts,” well illustrated book, and the chapters are written by leaders in the field of hair transplantation. All aspects are covered: the consultation, medical treatments for hair transplantation, the donor area, hairline design, and the treatment of scarri...

Relation between treatment efficacy and cumulative dose of 3% topical minoxidil in male pattern baldness

Journal of the American Academy of Dermatology — Mon, 19 Dec 2011 05:52:16 +0100

The objective of this study was to evaluate the association between efficacy and cumulative dose of topical minoxidil solution in the treatment of AGA during a 24-week period. (Source: Journal of the American Academy of Dermatology)

Response rate and duration associated with a 4gy 5 fraction palliative radiation protocol

Veterinary Radiology and Ultrasound — Mon, 19 Dec 2011 05:00:00 +0100

The purpose of this retrospective study was to determine if 4Gy fractions over 5 consecutive days is an effective and safe palliative radiation protocol for dogs and cats. Eighty patients (22 cats, 58 dogs) with complete follow‐up information were evaluated. Overall response rate (ORR) for all patients was 67%. Median progression free survival (MPFS) was 3.3 months and median survival (MST) was 4.2 months. Primary bone tumors were the most common tumors treated. The ORR for primary bone tumors was 66.6%, the MPFS was 3.5 months, and MSTwas 3 months. The most common tumor treated in cats was oral squamous cell carcinoma and ORR was 54.5 %, the MPFS was 1.8 months, and MST was 3 months. Soft tissue sarcomas were the second most common tumor treated in dogs (10). ORR was 80% and the two oth...

Facial Papules in Frontal Fibrosing Alopecia: Evidence of Vellus Follicle Involvement [Observation]

Archives of Dermatology — Mon, 19 Dec 2011 05:00:00 +0100

Conclusions The new concept of frontal fibrosing alopecia as a generalized disease is important for treatment planning and research. Dermatologists must learn to recognize facial surface changes and discuss these with the patients, who may attribute this roughness to aging or hormonal changes associated with menopause. Further studies are needed to determine the prevalence of this involvement in patients with frontal fibrosing alopecia. (Source: Archives of Dermatology)

Prevalence of Central Centrifugal Cicatricial Alopecia [Correspondence]

Archives of Dermatology — Mon, 19 Dec 2011 05:00:00 +0100

(Source: Archives of Dermatology)

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Prevalence of Central Centrifugal Cicatricial Alopecia--Reply [Correspondence]

Archives of Dermatology — Mon, 19 Dec 2011 05:00:00 +0100

(Source: Archives of Dermatology)

Effects of alopecia on body image and quality of life of Turkish cancer women with or without headscarf

Supportive Care in Cancer — Sat, 17 Dec 2011 06:45:12 +0100

Conclusion Although there were many important factors, multivariate analysis showed that for body image, having alopecia and wearing headscarves; and for quality of life, having alopecia were the variables that had considerable effects. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00520-011-1338-yAuthors Ozgul Erol, Faculty of Health Sciences, Trakya University, Aysekadin Kampus, Edirne, TurkeyGulbeyaz Can, Faculty of Nursing, Istanbul University, Istanbul, TurkeyAdnan Aydıner, Institute of Oncology, Istanbul University, Istanbul, Turkey Journal Supportive Care in CancerOnline ISSN 1433-7339Print ISSN 0941-4355 (Source: Supportive Care in Cancer)

Coexistence of acquired hypertrichosis and scalp alopecia in a patient with infiltrating ductal carcinoma

Indian Journal of Dermatology, Venereology and Leprology — Sat, 17 Dec 2011 05:00:00 +0100

Ru-Zhi Zhang, Wen-Yuan Zhu, Lei ZhouIndian Journal of Dermatology, Venereology, and Leprology 2012 78(1):122-122 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Severe diffuse non‐scarring hair loss in systemic lupus erythematosus – clinical and histopathological analysis of four cases

Journal of the European Academy of Dermatology and Venereology — Sat, 17 Dec 2011 05:00:00 +0100

Conclusion The severe type of hair loss in patient with SLE presents a unique set of clinical, dermoscopic and histopathological features. (Source: Journal of the European Academy of Dermatology and Venereology)

Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

Experimental Dermatology — Fri, 16 Dec 2011 05:59:37 +0100

AbstractInterferon‐γ (IFNγ)‐induced collapse of hair follicle (HF) immune privilege (IP) is a key element in the pathogenesis of alopecia areata. In this pilot study, we investigated whether the immunosuppressive neuropeptide, calcitonin gene‐related peptide (CGRP), can protect from and/or restore IFNγ‐induced HF IP‐collapse. After showing that human scalp HFs express CGRP receptor‐like (CRLR) immunoreactivity, anagen HFs were cultured in the presence of IFNγ, with CGRP added before or after. Adding CGRP after IFNγ administration (“restoration assay”) failed to downregulate IFNγ‐induced ectopic MHC class I expression, while MHC class II expression was reduced. However, administering CGRP before IFNγ application (“protection assay”) significantly reduced the IFN...

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Guidelines for the management of androgenetic alopecia (2010)

The Journal of Dermatology — Fri, 16 Dec 2011 05:00:00 +0100

(Source: The Journal of Dermatology)

Summary: International Kidney Cancer Symposium

Kidney Cancer Association — Thu, 15 Dec 2011 16:51:59 +0100

Conclusions: Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR. No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question for this presentation was: is there a future for robotic PN? At Society of Urologic Oncology (SUO) 2007 meeting there ...

Development of lepromatous leprosy following etanercept treatment for arthritis

Clinical Rheumatology — Wed, 14 Dec 2011 16:40:31 +0100

We present a case of a patient treated with etanercept (TNF-a antagonist) for psoriatic arthritis, who then developed clinical symptoms of lepromatous leprosy. She presented with multiple erythematous plaques on trunk, face and extremities, saddle nose deformity, alopecia, articular deformities of the feet and peroneal neuropathy. The clinical suspicion of Hansen’s Disase was confirmed by the biopsy findings (lepromatous leprosy). On further questioning, the patient stated that her father was diagnosed with leprosy 70 years ago and had spent some years in a leper colony in Spinalonga island in Southern Greece in the 1940s. This first report of Hansen’s disease after administration of etanercept highlights the need of careful risk assessment of patients for whom antiTNF treat...

Dietary cysteine is used more efficiently by children with severe acute malnutrition with edema compared with those without edema.

The American Journal of Clinical Nutrition — Wed, 14 Dec 2011 05:00:00 +0100

CONCLUSION: These findings suggest that children with edematous SAM may have a greater requirement for cysteine during early and mid-nutritional rehabilitation because they used dietary cysteine more efficiently than did their nonedematous counterparts and because the splanchnic tissues of all children with SAM have a relatively high requirement for cysteine. This trial was registered at clinicaltrials.gov as NCT00069134. PMID: 22170355 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)

Clinical Aspects of Dermatitis Associated with Dirofilaria repens in Pets: A Review of 100 Canine and 31 Feline Cases (1990–2010) and a Report of a New Clinic Case Imported from Italy to Dubai

International Journal of Biomedical Imaging — Tue, 13 Dec 2011 21:25:00 +0100

Cutaneous dirofilariasis is a parasitic disease caused by the mosquito-borne filarial nematodes Dirofilaria (Nochtiella) repens, living in the subcutaneous tissue of dogs, cats, wild carnivores, and humans. Cases have been recently reported also from Germany, Czech Republic, Hungary, Ukraine, Russia, Austria, Switzerland, France, The Netherlands, and the Middle East. D. repens is not widely known to cause chronic pruritic dermatitis in animals. Dermatological signs observed in 100 canine clinic cases were pruritus (100%), erythema (79%), papulae (62%), focal or multifocal alopecia (55%), hyperkeratosis (18%), crusting (14%), nodules (12%), acantosis (5%), and eczema (3%). Signs other than dermatological were conjunctivitis (46%), anorexia (35%), ...

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Renbök phenomenon in a patient with alopecia areata universalis and psoriasis

The Journal of Dermatology — Tue, 13 Dec 2011 05:00:00 +0100

(Source: The Journal of Dermatology)

Development and characterization of phyto-vesicles of β-sitosterol for the treatment of androgenetic alopecia

Archives of Dermatological Research — Mon, 12 Dec 2011 17:13:17 +0100

The objective of the present study is to enhance the bioavailability of β-sitosterol by its complexation with phosphatidyl choline and then to formulate it as phyto-vesicles for the treatment of alopecia. The complex of β-sitosterol was prepared with phosphatidyl choline and characterized on the basis of solubility, melting point, TLC, UV, IR and NMR spectroscopy. This complex was then formulated as phyto-vesicles and then characterized. The results revealed that effect on alopecia is better in case of phyto-vesicles as compared to the complex, physical mixture and the β-sitosterol itself. Enhanced bioavailability of the β-sitosterol complex may be due to the amphiphilic nature of the complex, which greatly enhance the water and lipid solubility of the compound. The present study...

Health Highlights: Dec. 9, 2011

Primary Care News - Doctors Lounge — Fri, 09 Dec 2011 16:29:00 +0100

Eating Raw Cookie Dough Raises Illness Risk: Study Cantaloupe Listeria Outbreak That Caused 30 Deaths Over: CDC Skin Around Hair Follicles Plays Role in Baldness: Study Numerous Problems at Cancer Drug Factory: FDA No Link Between Abortion, Risk of Mental Health Problems: Study (Source: Primary Care News - Doctors Lounge)

Chemotherapy with modified docetaxel, cisplatin, and 5-fluorouracil in patients with metastatic head and neck cancer.

Advances in Therapy — Fri, 09 Dec 2011 05:00:00 +0100

CONCLUSION: The mTPF chemotherapy regimen is efficacious for the palliative treatment of recurrent and metastatic HNSCC in Asian patients. PMID: 22161550 [PubMed - as supplied by publisher] (Source: Advances in Therapy)

New baldness treatments a step closer after scientists study animals¿ winter coats

the Mail online | Health — Thu, 08 Dec 2011 09:45:21 +0100

Researchers from the University of Southern California are on the verge of creating a new form of baldness treatment, after studying the way animals grow and shed their winter coats. (Source: the Mail online | Health)

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Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism

European Journal of Clinical Investigation — Thu, 08 Dec 2011 06:48:23 +0100

Conclusions A number of patients presenting with hirsutism and exhibiting similar features to PCOS may have other underlying diagnoses. Unlike PCOS, some of these disorders can occasionally be life threatening and require prompt diagnosis and treatment. (Source: European Journal of Clinical Investigation)

The "Fringe Sign" - A useful clinical finding in traction alopecia of the marginal hair line.

Dermatol Online J — Wed, 07 Dec 2011 17:30:03 +0100

CONCLUSIONS: The fringe sign is a sensitive and specific clinical feature of traction alopecia when it involves the marginal hairline. PMID: 22136857 [PubMed - in process] (Source: Dermatol Online J)

Alopecia areata triggered or exacerbated by swine flu virus infection

The Journal of Dermatology — Mon, 05 Dec 2011 05:00:00 +0100

(Source: The Journal of Dermatology)

Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation.

The American Journal of Pathology — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Zhou Y, Jiang X, Gu P, Chen W, Zeng X, Gao X Abstract Primary cicatricial alopecias (PCAs) are a group of permanent hair loss disorders, of which the pathogenesis is still poorly understood. The alopecia and excoriation (AE) mouse strain is a dominant mutant generated from ethyl nitrosourea mutagenesis. AE mice exhibit a progressive alopecia phenotype similar to that seen in PCAs, resulting from a point mutation in the gasdermin A3 (Gsdma3) gene. Mutant mice begin to show alopecia on the head from postnatal day 22 and experience complete hair loss by the age of 6 months, along with hyperkeratosis and catagen delay. The results of a histological examination showed that bulge stem cells in AE skin are gradually depleted, as indicated by decreased keratin 15 and CD34 expressi...

De novo 911 Kb interstitial deletion on chromosome 1q43 in a boy with mental retardation and short stature.

European Journal of Medical Genetics — Fri, 02 Dec 2011 05:00:00 +0100

In this report, we describe a 7 years old male with mental retardation, cryptorchid testes, short stature and alopecia carrying only an interstitial de novo deletion of 911 Kb in the 1q43 region (239,597,095-240,508,817) encompassing three genes CHRM3, RPS7P5 and FMN2. PMID: 22186213 [PubMed - as supplied by publisher] (Source: European Journal of Medical Genetics)

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Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko’s lines: A distinct variant of lupus panniculitis in East Asians?

The Journal of Dermatology — Thu, 01 Dec 2011 05:00:00 +0100

AbstractA 32‐year‐old Taiwanese man presented to our clinic with a 6‐month history of linear hair loss in a wavy and curved pattern across the parietal and occipital scalp, resembling the distribution of Blaschko’s lines. Physical examination showed interfollicular erythema and follicular plugging without skin atrophy or sclerotic change. Histopathology revealed a lymphoplasmacytic infiltrate in the perifollicular dermis and subcutis with abundant mucin deposition, consistent with the diagnosis of lupus panniculitis. Treatment with hydroxychloroquine and local steroid injection resulted in complete hair regrowth but recurrence was noted. Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko’s lines had so far been reported exclusively in five East Asians. A...

Hutchinson-Gilford Progeria Syndrome with G608G LMNA Mutation.

J Korean Med Sci — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Kim HK, Lee JY, Bae EJ, Oh PS, Park WI, Lee DS, Kim JI, Lee HJ Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by Hutchinson in 1886. Death result from cardiac complications in the majority of cases and usually occurs at average age of thirteen years. A 4-yr old boy had typical clinical findings such as short stature, craniofacial disproportion, alopecia, prominent scalp veins and sclerodermatous skin. This abnormal appearance began at age of 1 yr. On serological and hormonal evaluation, all values are within normal range. He was neurologically intact with motor and mental development. An echocardiogram showed calcification of aortic and mitral valves. Hypertrophy of internal layer at internal carotid artery suggesting atherosc...

The Effect of Cigarette Smoking on Cancer Treatment-Related Side Effects.

The Oncologist — Thu, 01 Dec 2011 05:00:00 +0100

Conclusion. Smoking was associated with an increased symptom burden during and following treatments for cancer. Targeted cessation efforts for smokers to decrease symptom burden may limit the likelihood of treatment interruptions and increase quality of life following treatment. PMID: 22135122 [PubMed - as supplied by publisher] (Source: The Oncologist)

[What's new in dermatological research?].

Annales de Dermatologie et de Cenereologie — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Aubin F Abstract Dermatological research has been very active this year. Most of the numerous fields investigated involve the mechanisms of cutaneous regeneration and barrier function. A novel target of early ultraviolet-induced skin photodamage, the Syk kinase, has been recently identified. Synergistic relationship between telomere damage and cutaneous progerin production during cell senescence may also participate in the natural skin aging process. Interestingly, ultraviolet radiation induces an inhibitory effect on subcutaneous lipogenesis. Androgenetic alopecia or common baldness is not characterized by loss of hair follicle stem cells but by a defect in the conversion of hair follicle stem cells into active progenitor cells. It has been shown that the cornified envelo...

Treatment for chemotherapy‐induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

International Journal of Cancer — Wed, 30 Nov 2011 05:00:00 +0100

AbstractParathyroid hormone (PTH) agonists and antagonists have been shown to improve hair growth after chemotherapy; however, rapid clearance and systemic side‐effects complicate their usage. To facilitate delivery and retention to skin, we fused PTH agonists and antagonists to the collagen binding domain of Clostridium histolyticum collagenase. In‐vitro studies showed that the agonist fusion protein, PTH‐CBD, bound collagen and activated the PTH/parathyroid hormone‐related peptide (PTHrP) receptor in SaOS‐2 cells. The antagonist fusion proteins, PTH(7‐33)‐CBD and PTH([‐1]‐33)‐CBD, also bound collagen and antagonized PTH(1‐34) effect in SaOS‐2 cells; however, PTH(7‐33)‐CBD had lower intrinsic activity. Distribution studies confirmed uptake of PTH‐CBD to the s...

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Hereditary Mucoepithelial Dysplasia: Report of Two Sporadic Cases

Pediatric Dermatology — Mon, 28 Nov 2011 05:00:00 +0100

We report on two unrelated patients who presented with typical clinical and histologic features of HMD along with other unreported clinical findings. (Source: Pediatric Dermatology)

Alopecia as a rare but distinct manifestation of pemphigus vulgaris

Journal of the European Academy of Dermatology and Venereology — Mon, 28 Nov 2011 05:00:00 +0100

Conclusion In PV, the combination of anti‐desmoglein autoantibody‐mediated acantholysis in conjunction with secondary factors, such as inflammatory changes due to infection, may cause weakening of hair follicle anchorage resulting in hair loss and alopecic patches. This unusual clinical phenotype should alert physicians to PV as a potential diagnosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Use of pegylated interferon in hypereosinophilic syndrome

Leukemia Research — Mon, 28 Nov 2011 05:00:00 +0100

We describe 6 patients with HES—1 patient with a newly identified chromosomal abnormality—who received PEG-IFNs. PEG-IFN alpha-2b replaced interferon (IFN) alpha-2b for 4 patients and was initial treatment of 2 patients. PEG-IFN alpha-2a was substituted when PEG-IFN alpha-2b became unavailable. PEG-IFNs were well tolerated and controlled eosinophilia. The dose of PEG-IFNs often could be tapered and the interval between doses lengthened beyond 7days. Adverse effects included dose-related increases in liver enzyme levels, hair loss, mild lymphopenia, and neutropenia. PEG-IFNs are effective treatment of HES. (Source: Leukemia Research)

Escitalopram: Alopecia: case report

Reactions — Tue, 22 Nov 2011 06:51:47 +0100

(Source: Reactions)

Central centrifugal cicatricial alopecia – an approach to diagnosis and management

International Journal of Dermatology — Tue, 22 Nov 2011 05:52:33 +0100

AbstractCentral centrifugal cicatricial alopecia (CCCA) occurs primarily in African–American women and is the most common cause of scarring hair loss in this population. Since the mid 20th century, hair care practices of African–American women have been associated with CCCA, although there is developing evidence that the etiology of CCCA may be multifactorial. Clinically diagnosing CCCA may be challenging because it can resemble female pattern hair loss, alopecia areata, lichen planopilaris, or telogen effluvium. Therapeutic options are limited, thus the goal of treatment is to prevent progression of disease because once scar formation occurs, it is irreversible. (Source: International Journal of Dermatology)

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Field melanin mapping of the hairless scalp

Skin Research and Technology — Tue, 22 Nov 2011 05:00:00 +0100

ConclusionThe present observations based on dual optical methods possibly provide information about a patterned pathobiology of melanocytes on the scalp. The spotty MSM pattern looked similar to the reported aspects on the face. It somewhat resembled the widespread PUVA‐induced lentiginosis. (Source: Skin Research and Technology)

Alteration in Hair Texture Following Regrowth in Alopecia Areata: A Case Report [Observation]

Archives of Dermatology — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions The precipitating factor for a change in hair texture in alopecia areata may be a result of treatment, pathophysiologic changes, or a combination of both. Whether the change is triggered at the level of stem cell differentiation, by cytokine or hormonal influences, gene expression during hair follicle development, a combination of all of these, or an unknown cause is a question that remains to be answered. (Source: Archives of Dermatology)

Low-Dose Excimer 308-nm Laser for Treatment of Lichen Planopilaris [Research Letters]

Archives of Dermatology — Mon, 21 Nov 2011 05:00:00 +0100

(Source: Archives of Dermatology)

Connubial Androgenetic Alopecia [Correspondence]

Archives of Dermatology — Mon, 21 Nov 2011 05:00:00 +0100

(Source: Archives of Dermatology)

An alternative approach for Mohs surgery using a combination of a flexible blade and the traditional scalpel

Journal of the European Academy of Dermatology and Venereology — Mon, 21 Nov 2011 05:00:00 +0100

Discussion The use of the flexible blade alone in Mohs may yield jagged tissue peripheral edges after cutting on the cryostat. The classic technique with a scalpel excision often results in a deeper cut than desired, resulting in a larger defect. We modified both the traditional Mohs technique and the flexible blade by combining both. We have performed this method in approximately over 100 cases on the scalp, face and ears, preserving tissue, minimizing bleeding and avoiding alopecia. (Source: Journal of the European Academy of Dermatology and Venereology)

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Age-Specific Administration of Chemotherapy and Long-Term Quality of Life in Stage II and III Colorectal Cancer Patients: A Population-Based Prospective Cohort.

The Oncologist — Fri, 18 Nov 2011 05:00:00 +0100

Discussion. Chemotherapy is associated with lower long-term QoL, especially in younger survivors. In cases of uncertain survival benefits of chemotherapy, consideration of its long-term effects on QoL should be incorporated into final decisions on treatment. PMID: 22101506 [PubMed - as supplied by publisher] (Source: The Oncologist)

Narrowband ultraviolet B phototherapy for alopecia areata

Photodermatology, Photoimmunology and Photomedicine — Thu, 17 Nov 2011 10:59:41 +0100

SummaryAlthough narrowband ultraviolet B (NB UVB) phototherapy is a well‐established treatment in many dermatosis, there is little evidence of efficacy of this method for alopecia areata (AA) treatment in the literature. We undertook a retrospective review of the 25 AA patients treated with NB UVB. Intramuscular triamcinolone acetonide injections per month were used as concomitant treatment in some patients who did not have any contraindication. Eight patients (32%) received monthly intramuscular corticosteroid injections. Four (22.2%) and two (20%) patients achieved excellent response in extensive patchy hair loss patients and entire scalp hair loss patients, respectively. Four of six patients who achieved excellent response also received monthly intramuscular corticosteroid injections....

Alopecia areata incognita

Journal of the American Academy of Dermatology — Wed, 16 Nov 2011 21:07:47 +0100

To the Editor: I read with great interest the report of the dermoscopic features of alopecia areata incognita (AAI) by Tosti et al and the reply by Rakowska et al. As the first researcher to describe AAI, I feel entitled to participate to the discussion. What I consider AAI mimics a very severe telogen effluvium in a patient with apparently normal hair density. The pull test is impressively positive, and the facial hairs may be affected. Over months to years, diffuse hair thinning evolves, and some patients develop small glabrous areas. The likelihood of finding dystrophic hairs with a random trichogram or biopsy for histopathology is poor. The modified wash test, which collects hairs from the entire scalp, yields at least 350 terminal telogen hairs and may reveal up to 800, with occasi...

Acitretin: Excess nail sulci granulation tissue and alopecia: case report

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

(Source: Reactions)

Fluorouracil/gemcitabine: Nausea, vomiting and alopecia: case report

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

(Source: Reactions)

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ANH FEATURE: UK television breaks new ground with ‘food as medicine’ concept

Alliance for Natural Health — Wed, 09 Nov 2011 11:45:41 +0100

ANH evaluates the first two of eight episodes of The Food Hospital (Source: Alliance for Natural Health)

Trichotemnomania: Hair Loss Mediated by a Compulsive Habit Not Admitted by Patients.

Acta Dermato-Venereologica — Wed, 09 Nov 2011 05:00:00 +0100

Authors: Orgaz-Molina J, Husein-Elahmed H, Soriano-Hernández MI, Arias-Santiago S PMID: 22068260 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours

Current Oncology — Tue, 08 Nov 2011 15:59:50 +0100

ConclusionsIn the present study, BI 2536 showed an acceptable safety profile warranting further investigation of Plk1 inhibitors in this patient population. (Source: Current Oncology)

Health Q&A: low-carbohydrate diet and hair loss

Telegraph Health — Fri, 04 Nov 2011 15:52:04 +0100

Britain's health and wellbeing specialists answer your questions (Source: Telegraph Health)

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Tumor necrosis factor-alpha in patients with alopecia areata

Indian Journal of Dermatology — Fri, 04 Nov 2011 04:00:00 +0100

Conclusion : Our findings support the evidence that elevation of serum TNF-α is associated with AA. The exact role of serum TNF-α in AA should be additionally investigated in future studies. (Source: Indian Journal of Dermatology)

Skin lesions in lupus erythematosus: A marker of systemic involvement

Indian Journal of Dermatology — Fri, 04 Nov 2011 04:00:00 +0100

Conclusion: Identification of lesions with high degree of association with SLE can alert the physician of the unfavorable prognosis and allow timely intervention and institution of appropriate management strategies. (Source: Indian Journal of Dermatology)

Eek! Hair loss in women: Top 7 risk factors revealed

Health News: CBSNews.com — Thu, 03 Nov 2011 16:30:49 +0100

Can divorce make women lose their locks? How about high income? Study of female twins reveals big surprises (Source: Health News: CBSNews.com)

Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case-control study.

The British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact which may bring about anxiety or depression, stress-neuroendocrine-immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. PMID: 22049923 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case‐control study

British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact which may bring about anxiety or depression, stress‐neuroendocrine‐immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. (Source: British Journal of Dermatology)

Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case–control study

British Journal of Dermatology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions AA is related to various psychiatric disorders. Onset age of AA is an important factor in the association with different comorbid psychiatric diseases. In addition to cosmetic impact, which may bring about anxiety or depression, stress neuroendocrine immunology may play an important role in the pathogenesis of both AA and psychiatric disorders. (Source: British Journal of Dermatology)

Graham-Little-Piccardi-Lassueur syndrome.

Dermatol Online J — Wed, 02 Nov 2011 03:40:04 +0100

We present a patient with lichen planopilaris, lichen planus pigmentosus, and nonscarring alopecia of the genitals, who is reminiscent of GLPLS. Recent work shows evidence for autoimmunity in GLPLS. Further elucidation of underlying mechanisms can improve categorization and treatment options in this rare and controversial syndrome. PMID: 22031656 [PubMed - in process] (Source: Dermatol Online J)

Lupus erythematosus tumidus with discoid lupus erythematosus-induced alopecia of the scalp.

Dermatol Online J — Wed, 02 Nov 2011 03:40:04 +0100

We present a unique case of alopecia associated with LET, which was partially responsive to hydroxychloroquine. We also note that the plaque of LET is adjacent to the plaque of discoid lupus erythematosus. PMID: 22031650 [PubMed - in process] (Source: Dermatol Online J)

Valproate-induced hair loss: What to tell patients

Pearls — Tue, 01 Nov 2011 12:31:00 +0100

Shailesh Jain, MD, MPH, ABDA; Beth Beste, MS (Source: Pearls)

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Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six‐month, randomized, double‐blind, placebo‐controlled, proof‐of‐concept pilot study at a single center

Arthritis and Rheumatism — Tue, 01 Nov 2011 04:00:00 +0100

ConclusionImatinib was poorly tolerated, and this could limit its application in SSc. The study was too small to form conclusions about the efficacy of imatinib in SSc. (Source: Arthritis and Rheumatism)

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model.

Cell Stress and Chaperones — Tue, 01 Nov 2011 04:00:00 +0100

In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model. Mice with spontaneous AA were treated with subcutaneous quercetin or sham injections. Hair regrowth was observed in lesional areas in all the quercetin-treated mice, but in none of the sham-treated mice. In addition, non-alopecic C3H/HeJ mice were heat-treated to induce alopecia, along with quercetin or sham injections. Whereas 24% of the heat-treated mice with sham injections developed alopecia, none of the mice receiving quercetin injections did. As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control. Furthermore, we showed that systemic delivery of quercetin by intraperitoneal injections...

Congenital hair loss disorders: Rare, but not too rare

The Journal of Dermatology — Tue, 01 Nov 2011 04:00:00 +0100

AbstractThe mammalian hair follicle (HF) is an active skin appendage which operates hair cycles throughout life. Recent advances in molecular genetics have led to the identification of many genes expressed in the HF. Furthermore, mutations in some of these genes have been shown to underlie congenital hair loss disorders in humans. Patients with congenital hair loss disorders can show various hair shaft anomalies, such as woolly hair and monilethrix. In the Japanese populations, most patients with congenital woolly hair/hypotrichosis possess common founder mutations in the lipase H (LIPH) gene. Identification of the causative genes for hair loss disorders directly demonstrates crucial roles of these genes in HF morphogenesis, development and/or hair growth in humans. (Source: The Journal of...

Novel SLC39A4 Mutation in Acrodermatitis Enteropathica

Pediatric Dermatology — Tue, 01 Nov 2011 04:00:00 +0100

We describe a novel homozygous mutation, 1191insC, in SLC39A4 in a patient from Sierra Leone and suggest that AE should be considered within the differential diagnosis for acrodermatitis in children from Sierra Leone. Genetic testing for this founder mutation can be easily performed for this treatable disorder. (Source: Pediatric Dermatology)

Primary cicatricial alopecia: Recent advances in understanding and management

The Journal of Dermatology — Tue, 01 Nov 2011 04:00:00 +0100

AbstractPrimary cicatricial alopecias (PCA) are a rare group of disorders, in which the hair follicle is the main target of destructive inflammation resulting in irreversible hair loss with scarring of affected lesions. The most typical clinical manifestation of PCA is the loss of visible follicular ostia. The histopathological hallmark of a fully developed lesion is the replacement of the hair follicle structure by fibrous tissue. PCA could share similar clinical manifestations and eventually lead to “burn‐out” alopecia. Some subsets are hardly distinguishable histopathologically and the mechanisms that elicit such a destructive reaction have not been fully elucidated. Thus, the management of PCA represents one of the most challenging clinical problems for dermatologists. The aim of...

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Anti‐tumor necrosis factor‐α therapies for immune‐mediated and inflammatory skin diseases

Drug Development Research — Tue, 01 Nov 2011 04:00:00 +0100

AbstractAnti‐tumor necrosis factor‐α (TNF‐α) therapies, also called biologic therapies or immunotherapies, are being used increasingly in dermatology, rheumatology, and gastroenterology in the context of established and emerging indications. Anti‐TNF agents target TNF‐α and include infliximab (a chimeric IgG1 monoclonal antibody), adalimumab (a fully human recombinant IgG1 monoclonal antibody), and etanercept (a dimeric fusion protein of TNFR1 linked to the Fc portion of IgG1). Among skin diseases, only plaque psoriasis represents an approved indication for the use of anti‐TNF‐α agents; however, anti‐TNF therapies have been used as off‐label treatments in a plethora of immune‐mediated or inflammatory cutaneous disorders, such as hidradenitis suppurativa, alopecia ar...

Wart Treatment Compound May Treat Leukemia Effectively

Health News from Medical News Today — Fri, 28 Oct 2011 12:00:00 +0100

Researchers have developed a new potential leukemia therapy that specifically targets cancerous cells, without attacking healthy cells. At present the majority of chemotherapy treatments attack both cancer cells and healthy cells, causing considerable adverse effects, such as depression, anxiety, nausea, hair loss and fatigue. The research is currently being presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23 - 27... (Source: Health News from Medical News Today)

Compound Found In Common Wart Treatment Shows Promise As Leukemia Therapy

Health News from Medical News Today — Fri, 28 Oct 2011 08:00:00 +0100

A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression. This research was presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23 - 27. Leukemia is a cancer of the blood and bone marrow, the spongy center of bones where blood cells are formed... (Source: Health News from Medical News Today)

NaturalNews issues consumer alert about Adya Clarity, imported as battery acid and sold for internal consumption

NaturalNews.com — Fri, 28 Oct 2011 07:00:00 +0100

(NaturalNews) A product called Adya Clarity has been sweeping across the natural health community in the last year or so. It has been sold with recommendations for internal use -- taking "super shots" -- and often accompanied by wide-ranging claims that it treats cancer, kidney stones, hormone regulation, arthritis, and that it removes radiation and heavy metals.Because so many readers have been asking me about Adya Clarity, I decided to look further into the issue. I was aided by some timely tips that came my way which I began to check out as an investigative journalist. What I found -- much of which is detailed in this report -- absolutely shocked me. But what do YOU think? Read my report and decide for yourself.Unsubstantiated health claims The claims that Adya Clarity is good for treat...

Is hair loss a reality in neuro-interventional radiology?

Radiation Protection Dosimetry — Fri, 28 Oct 2011 04:00:00 +0100

Reports in the literature of radiation-induced hair loss are becoming increasingly common. This work describes a retrospective dose study of patients (n=958) undergoing diagnostic (primarily cerebral angiograms) and therapeutic (primarily cerebral embolisation) procedures in a neuro-interventional suite. A comparison of patient doses as dose area product (DAP) readings from a single-plane image intensifier system (mean DAP value of 8772 cGy cm²) were compared with patient doses from a flat panel biplane system (mean DAP value of 7855 cGy cm²). Over 80 % of patients requiring neuro-interventional procedures were found to undergo two procedures or more. An estimated 7 % of therapeutic procedures were found to reach the International Commission on Radiological Protection threshold f...

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An usual cause of progressive hair loss

Internal and Emergency Medicine — Thu, 27 Oct 2011 15:45:38 +0100

Content Type Journal ArticleCategory CE - MEDICAL ILLUSTRATIONPages 1-2DOI 10.1007/s11739-011-0708-2Authors John Edwin Jesus, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd., Boston, MA 02215, USAEdward Ullman, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd., Boston, MA 02215, USA Journal Internal and Emergency MedicineOnline ISSN 1970-9366Print ISSN 1828-0447 (Source: Internal and Emergency Medicine)

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male‐pattern baldness

British Journal of Dermatology — Thu, 27 Oct 2011 04:00:00 +0100

Conclusions: The present study suggests that HDAC9 is the third AGA susceptibility gene. (Source: British Journal of Dermatology)

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.

The British Journal of Dermatology — Thu, 27 Oct 2011 04:00:00 +0100

Conclusions: The present study suggests that HDAC9 is the third AGA susceptibility gene. PMID: 22032556 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Compound found in common wart treatment shows promise as leukemia therapy

EurekAlert! - Medicine and Health — Wed, 26 Oct 2011 04:00:00 +0100

(American Association of Pharmaceutical Scientists) A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression. This research is being presented at the 2011 American Association of Pharmaceutical Scientists Annual Meeting and Exposition in Washington, D.C., Oct. 23 - 27. (Source: EurekAlert! - Medicine and Health)

Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata

European Journal of Human Genetics — Wed, 26 Oct 2011 04:00:00 +0100

Authors: Lina M Forstbauer, Felix F Brockschmidt, Valentina Moskvina, Christine Herold, Silke Redler, Alexandra Herzog, Axel M Hillmer, Christian Meesters, Stefanie Heilmann, Florian Albert, Margrieta Alblas, Sandra Hanneken, Sibylle Eigelshoven, Kathrin A Giehl, Dagny Jagielska, Ulrike Blume-Peytavi, Natalie Garcia Bartels, Jennifer Kuhn, Hans Christian Hennies, Matthias Goebeler, Andreas Jung, Wiebke K Peitsch, Anne-Katrin Kortüm, Ingrid Moll, Roland Kruse, Gerhard Lutz, Hans Wolff, Bettina Blaumeiser, Markus Böhm, George Kirov, Tim Becker, Markus M Nöthen & Regina C Betz (Source: European Journal of Human Genetics)

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The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome.

Mol Biol Cell — Wed, 26 Oct 2011 04:00:00 +0100

Authors: Mese G, Sellitto C, Li L, Wang HZ, Valiunas V, Richard G, Brink PR, White TW Abstract Mutations in the GJB2 gene (Cx26) cause deafness in humans. Most mutations are loss-of-function and cause non-syndromic deafness. Some mutations produce a gain-of-function and cause syndromic deafness associated with skin disorders, like keratitis-ichthyosis-deafness syndrome (KIDS). Cx26-G45E is a lethal mutation linked to KIDS that forms constitutively active connexin hemichannels. The pathomechanism(s) by which mutant Cx26 hemichannels perturb normal epidermal cornification are poorly understood. We created an animal model for KIDS by generating an inducible transgenic mouse expressing Cx26-G45E in keratinocytes. Cx26-G45E mice displayed reduced viability, hyperkeratosis, scaling, skin...

Ovarian cancer in elderly patients: carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in late relapse: a Gynecologic Cancer Intergroup (GCIG) CALYPSO sub-study

Annals of Oncology — Mon, 24 Oct 2011 04:00:00 +0100

Conclusions: Patients ≥70 years experienced more neuropathy, with a higher incidence in the C–P arm. Similar to all study patients, C–PLD provided a better therapeutic index with less toxicity than C–P in elderly women with platinum-sensitive ROC. (Source: Annals of Oncology)

First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer

Cancer Chemotherapy and Pharmacology — Fri, 21 Oct 2011 15:59:43 +0100

Conclusions The novel CENP-E inhibitor, GSK923295, had dose-proportional pharmacokinetics and a low number of grade 3 or 4 adverse events. The observed incidence of myelosuppression and neuropathy was low. Further investigations may provide a more complete understanding of the potential for GSK923295 as an antiproliferative agent. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00280-011-1756-zAuthors Vincent Chung, City of Hope Medical Center, 1500 East Duarte Road, Durate, CA 91010, USAElisabeth I. Heath, Karmanos Cancer Center, Detroit, MI, USAWilliam R. Schelman, University of Wisconsin Carbone Cancer Center, Madison, WI, USABrendan M. Johnson, GlaxoSmithKline, Research Triangle Park, NC, USALyndon C. Kirby, GlaxoSmithKline, Research T...

Face and scalp cosmetic surgery may increase lichen planopilaris risk

MedWire News - Dermatology — Fri, 21 Oct 2011 00:00:00 +0100

Evidence suggests that cosmetic procedures such as facelifts and hair transplants can increase the risk for lichen planopilaris, an inflammatory skin disorder that results in permanent alopecia and fibrous scarring over the hair follicles, or frontal fibrosing alopecia, say researchers. (Source: MedWire News - Dermatology)

Circumscribed Alopecia: An Unusual Manifestation of Pediculosis Capitis

Pediatric Dermatology — Thu, 20 Oct 2011 04:00:00 +0100

Abstract: A healthy 10‐year‐old girl was referred for evaluation of patchy hair loss on the scalp of longer than 6 months duration. She had been diagnosed and treated for head lice approximately 1 month before onset of the hair loss. Examination of the scalp showed discrete ovoid patches of hair loss at the vertex scalp. A scrape of the area of hair loss was performed, and a nit was visible on microscopic examination. Focal hair loss may represent an atypical manifestation of ongoing pediculosis capitis. (Source: Pediatric Dermatology)

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Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss

British Journal of Dermatology — Thu, 20 Oct 2011 04:00:00 +0100

(Source: British Journal of Dermatology)

Avodart 0.5mg soft capsules (Dutasteride)- Revised SPC

NeLM - SPC Changes — Thu, 20 Oct 2011 04:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes There have been several updates to the SPC, the following sections have been updated: Section 4.3 - Addition of contraindications to soya, peanut and other excipients Section 4.8 - Addition of Alopecia, hypertrichosis as uncommon side effect - Data from 4 year CombAT study Section 5.1 - Update to description of IPSS - Addition of Primary and secondary endpoints at 4 years treatment Please refer to SPC link below for full ...

Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss.

The British Journal of Dermatology — Thu, 20 Oct 2011 04:00:00 +0100

Authors: Yip L, Zaloumis S, Irwin D, Severi G, Hopper J, Giles G, Harrap S, Sinclair R, Ellis J PMID: 22014031 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Five ways to put a crimp in hair loss

USATODAY.com Health — Wed, 19 Oct 2011 23:53:08 +0100

Thinning hair? If you are female, good news: It's not all genetic, and there are ways to slow the shedding. (Source: USATODAY.com Health)

Video: Getting to the root of female hair loss

Health News: CBSNews.com — Tue, 18 Oct 2011 13:49:05 +0100

TV host Tabatha Coffey and dermatologist Dr. Doris day speaks to the "Early Show" anchors about female hair loss, some of the common causes and treatment options. (Source: Health News: CBSNews.com)

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No improvement in male‐pattern hair loss using laser hair‐comb therapy: a 6‐month, half‐head, assessor‐blinded investigation in two men

Clinical And Experimental Dermatology — Tue, 18 Oct 2011 04:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Alopecia Areata

MedicineNet Mens Health General — Mon, 17 Oct 2011 07:00:00 +0100

Title: Alopecia AreataCategory: Diseases and ConditionsCreated: 4/30/1999 5:53:00 PMLast Editorial Review: 10/17/2011 (Source: MedicineNet Mens Health General)

Lonely Hair: A Clue to the Diagnosis of Frontal Fibrosing Alopecia [skINsight]

Archives of Dermatology — Mon, 17 Oct 2011 04:00:00 +0100

(Source: Archives of Dermatology)

Palmar and plantar keratoderma, visual loss, and alopecia

Journal of the American Academy of Dermatology — Sat, 15 Oct 2011 05:13:26 +0100

A 33-year-old healthy man presents with a 2-month history of progressive visual loss, itching lesions on the palms and soles, and hair loss. The physical examination reveals hyperkeratotic plaques on the palms and soles (), moth-eaten alopecia (), and oropharyngeal candidiasis. An ophthalmic examination reveals panuveitis with nonreactive pupils and irregular border. The rest of his cutaneous and neurologic examination is normal. (Source: Journal of the American Academy of Dermatology)

Fixed focal alopecia for 20 years

Journal of the American Academy of Dermatology — Sat, 15 Oct 2011 05:13:25 +0100

Presented during the Gross and Microscopic Dermatology Symposium at the 70th Annual Meeting of the American Academy of Dermatology, San Diego, CA, March 16-20, 2011. A healthy 28-year-old white man presented with a focal area of hair loss. He had never tried any therapy. The area had been “bald” for at least 20 years and there was no intermittent hair growth or changes to the skin. He had a history of asthma but no additional medical problems. There was no family history of hair loss or autoimmune disease. The physical examination of the left temporal scalp revealed a focal patch of normal skin lacking terminal hairs but with intact follicular ostia containing vellus hairs (). A punch biopsy specimen was obtained (). (Source: Journal of the American Academy of Dermatology)

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Combodart 0.5 mg / 0.4 mg hard capsules- Revised SPC

NeLM - SPC Changes — Thu, 13 Oct 2011 04:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes The following sections of the SPC have been updated as follows: Section 4.3 -Contraindications Addition of contraindications to soya, peanut and other excipients Section 4.8 -Undesirable effects Addition of Alopecia, hypertrichosis as uncommon side effect Data from 4 year CombAT study Section 5.1- Pharmacodynamic Properties Update to description of IPSS (Addition of Primary and secondary endpoints at 4 years) Please refer to the SPC for detailed information on all the changes (Source: NeLM - SPC Changes)

Cyclophosphamide/paclitaxel: Alopecia and peripheral neuritis: case report

Reactions — Wed, 12 Oct 2011 06:03:59 +0100

(Source: Reactions)

Cell‐cell connectivity: desmosomes and disease

The Journal of Pathology — Wed, 12 Oct 2011 04:00:00 +0100

AbstractCell‐cell connectivity is an absolute requirement for the correct functioning of cells, tissues and entire organisms. At the level of the individual cell, direct cell‐cell adherence and communication is mediated by the intercellular junction complexes: desmosomes, adherens‐, tight‐ and gap‐junctions. A broad spectrum of inherited, infectious and auto‐immune diseases can affect the proper function of intercellular junctions, and result in either diseases affecting specific individual tissues or widespread syndromic conditions. A particularly diverse group of diseases result from direct or indirect disruption of desmosomes – a consequence of their importance in tissue integrity, their extensive distribution, complex structure, and the wide variety of functions their com...

Cell–cell connectivity: desmosomes and disease

The Journal of Pathology — Wed, 12 Oct 2011 04:00:00 +0100

AbstractCell–cell connectivity is an absolute requirement for the correct functioning of cells, tissues and entire organisms. At the level of the individual cell, direct cell–cell adherence and communication is mediated by the intercellular junction complexes: desmosomes, adherens, tight and gap junctions. A broad spectrum of inherited, infectious and auto‐immune diseases can affect the proper function of intercellular junctions and result in either diseases affecting specific individual tissues or widespread syndromic conditions. A particularly diverse group of diseases result from direct or indirect disruption of desmosomes—a consequence of their importance in tissue integrity, their extensive distribution, complex structure, and the wide variety of functions their components acc...

MedWorm: Alopecia

Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren's syndrome

Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

Effect of petroleum ether and ethanol fractions of seeds of Abrus precatorius on androgenic alopecia

DIY science: should you try this at home?

Successful calvarial bone salvage using multiple outer table perforation technique on total scalp avulsion injury

Pityriasis amiantacea: a distinctive presentation of psoriasis associated with tumour necrosis factor‐α inhibitor therapy

6 Year Old Cuts Her Mother's Hair to Prepare for Chemo

Alopecia Areata during Treatment of Psoriasis with Adalimumab and Leflunomide: A Case and Review of the Literature

Hair follicle stem cell differentiation is inhibited through a cross talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis

Hair loss, nail changes, GI symptoms – think selenium toxicity

Induction chemotherapy followed by concomitant radiotherapy and weekly cisplatin versus the same concomitant chemoradiotherapy in patients with nasopharyngeal carcinoma: a randomized phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation

A comment regarding ‘follicular Swiss cheese’ in the diagnosis of alopecia areata

The ‘Tyler technique’ for alopecia biopsies

The management of EGFR inhibitor adverse events: a case series and treatment paradigm.

Are medical communities the new marketing demographic?

The management of EGFR inhibitor adverse events: a case series and treatment paradigm

Treatment of folliculitis decalvans with tacrolimus ointment

Polarized Microscopy as a Helpful Tool to Distinguish Chronic Nonscarring Alopecia From Scarring Alopecia [Observation]

Long-term membranous glomerulonephritis as the presenting manifestation of systemic lupus erythematosus in a patient with human immunodeficiency virus infection.

Psychosocial impact of cicatricial alopecias

Oral doxycycline with topical tacrolimus for treatment of stasis dermatitis due to chronic venous insufficiency: A pilot study

Evaluation of Efficacy and Safety of Bevacizumab Combined with Chemotherapy for Chinese Patients with Advanced Non-small Cell Lung Cancer

Effects of Hura crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation.

Whorled hairless nevus of the scalp, linear hyperpigmentation, and telangiectatic nevi of the lower limbs: A novel variant of the “phacomatosis complex”

Olivia Rusk is your average teenager, just bald

Barbie Considers A No-Hair Day To Help Cancer Survivors

Olivia Rusk is your average teenager -- just bald

Friends connected by cancer campaign for bald Barbie

Cancer survivors petition online for bald Barbie

Nemo syndrome (incontinentia pigmenti) and systemic lupus erythematosus: a new disease association.

Frontal Fibrosing Alopecia in black patients.

Frontal Fibrosing Alopecia in black patients

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata

Conventional transarterial chemoembolisation in combination with sorafenib for patients with hepatocellular carcinoma: a pilot study

Lipedematous diseases of the scalp are not separate entities but part of a spectrum of lipomatous lesions

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Alopecia areata associated with haloperidol decanoate long-acting injection.

Advances in the management of alopecia areata

Hair biology and hair loss disorders: An update and new concepts

Behind the Headlines quiz of the year 2011

Intractable Diffuse Alopecia Caused by Multifactorial Side‐Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion

Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity.

Alopecia Areata, Comorbidities, and Age of OnsetAlopecia Areata, Comorbidities, and Age of Onset

Avoidance of overheating and selection for both hair loss and bipedality in hominins [Anthropology]

Menopausal-type symptoms among breast cancer patients on aromatase inhibitor therapy.

[Soft tissue reconstruction with a temporoparietal fascial flap (TPFF).]

A case of alopecia universalis with agminated lentiginosis and multiple café‐au‐lait macules: a synchronous coincidence?

Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3-hydroxyisovaleric acid in valproate-treated patients

Temsirolimus in combination with carboplatin and paclitaxel in patients with advanced solid tumors: a NCIC-CTG, phase I, open-label dose-escalation study (IND 179)

Association of discoid lupus with clinical manifestations and damage accrual in profile: A multiethnic lupus cohort

[Dermatofibrosarcoma protuberans in children.]

Interferon alpha for chronic hepatitis D.

Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients

Assessment of hair density and caliber in Caucasian and Asian female subjects with female pattern hair loss by using the Folliscope

Hair transplantation

Relation between treatment efficacy and cumulative dose of 3% topical minoxidil in male pattern baldness

Response rate and duration associated with a 4gy 5 fraction palliative radiation protocol

Facial Papules in Frontal Fibrosing Alopecia: Evidence of Vellus Follicle Involvement [Observation]

Prevalence of Central Centrifugal Cicatricial Alopecia [Correspondence]

Prevalence of Central Centrifugal Cicatricial Alopecia--Reply [Correspondence]

Effects of alopecia on body image and quality of life of Turkish cancer women with or without headscarf

Coexistence of acquired hypertrichosis and scalp alopecia in a patient with infiltrating ductal carcinoma

Severe diffuse non‐scarring hair loss in systemic lupus erythematosus – clinical and histopathological analysis of four cases

Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

Guidelines for the management of androgenetic alopecia (2010)

Summary: International Kidney Cancer Symposium

Development of lepromatous leprosy following etanercept treatment for arthritis

Dietary cysteine is used more efficiently by children with severe acute malnutrition with edema compared with those without edema.

Clinical Aspects of Dermatitis Associated with Dirofilaria repens in Pets: A Review of 100 Canine and 31 Feline Cases (1990–2010) and a Report of a New Clinic Case Imported from Italy to Dubai

Renbök phenomenon in a patient with alopecia areata universalis and psoriasis

Development and characterization of phyto-vesicles of β-sitosterol for the treatment of androgenetic alopecia

Health Highlights: Dec. 9, 2011

Chemotherapy with modified docetaxel, cisplatin, and 5-fluorouracil in patients with metastatic head and neck cancer.

New baldness treatments a step closer after scientists study animals¿ winter coats

Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism

The "Fringe Sign" - A useful clinical finding in traction alopecia of the marginal hair line.

Alopecia areata triggered or exacerbated by swine flu virus infection

Evaluation of Efficacy and Safety of Bevacizumab Combined with Chemotherapy  for Chinese Patients with Advanced Non-small Cell Lung Cancer