MedWorm: Anaphylactic Shock

Timing of skin testing after a suspected anaphylactic reaction during anaesthesia

Acta Anaesthesiologica Scandinavica — Tue, 07 Feb 2012 05:00:00 +0100

ConclusionsOnly positive skin tests can be taken into account, and there is little safety data to provide confidence in early skin testing. A protocol of how to act if urgent surgery is necessary is suggested. (Source: Acta Anaesthesiologica Scandinavica)

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Which dental local anaesthetics are latex-free?

NeLM - Medicines Q and A — Tue, 07 Feb 2012 05:00:00 +0100

Source: North West Medicines Information Centre Area: Evidence > Medicines Q & A Natural rubber latex (NRL) is present in many medical products, including disposable gloves, adhesive tape and bungs in medicine vials. People sensitised to NRL are at risk of developing allergic reactions, which can present with delayed symptoms such as a localised red itchy rash or with immediate symptoms such as itching of the skin and eyes, sneezing, bronchospasm or anaphylactic shock. People sensitised to NRL should avoid contact with all products that contain it, either in the product itself, in the packaging or introduced during the manufacturing process or storage. This Medicines Q&A provides a list of local anaesthetic preparations used in dentistry which are late...

Natural vanadium-containing jeju groundwater inhibits immunoglobulin e-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells.

Biological and Pharmaceutical Bulletin — Mon, 06 Feb 2012 19:48:04 +0100

Authors: Li X, Lu Y, Yang JH, Jin Y, Hwang SL, Chang HW Abstract The high-affinity receptor for immunoglobulin E (IgE) (FcεRI)-mediated activation of mast cells plays an important role in various allergic diseases. To assess the anti-allergic activity of natural vanadium-containing Jeju groundwater (JW), an in vivo passive cutaneous anaphylaxis (PCA) animal model and in vitro mouse bone marrow-derived mast cells (BMMCs) was used. JW inhibited cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2) (PGD(2)) generation in a dose-dependent manner, with a concomitant reduction of COX-2 protein expression in IgE-induced BMMCs. In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of leukotriene C(4) (LTC(4)) as well as degranulation in a dose-dependent manner. These resul...

DIY science: should you try this at home?

Guardian Unlimited Science — Fri, 03 Feb 2012 22:59:00 +0100

When Richard Handl was arrested for attempting to split the atom on his stove, he joined a growing band of home experimenters cooking up all kinds of trouble behind the kitchen doorÄngelholm is a pretty southern Swedish town, famed for its clay cuckoo manufacturing, a clay cuckoo being a kind of ocarina, which is a kind of flute. The crime rate here is practically zero. Except one of its residents was last year arrested for trying to split the atom in his kitchen. His name is Richard Handl and he buzzes me into his first-floor flat.I wanted to meet Richard because I keep seeing reports of home science experimenters clashing with the authorities. There's been a spate of them this past year or two.I glance into Richard's kitchen and recognise his cooker from the news. It was horrendously, a...

Amiodarone: Anaphylaxis: case report

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

The Safety of Yellow Fever Vaccine 17D or 17DD in Children, Pregnant Women, HIV+ Individuals, and Older Persons: Systematic Review.

The American Journal of Tropical Medicine and Hygiene — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Thomas RE, Lorenzetti DL, Spragins W, Jackson D, Williamson T Abstract Abstract. Yellow fever vaccine provides long-lasting immunity. Rare serious adverse events after vaccination include neurologic or viscerotropic syndromes or anaphylaxis. We conducted a systematic review of adverse events associated with yellow fever vaccination in vulnerable populations. Nine electronic bibliographic databases and reference lists of included articles were searched. Electronic databases identified 2,415 abstracts for review, and 32 abstracts were included in this review. We identified nine studies of adverse events in infants and children, eight studies of adverse events in pregnant women, nine studies of adverse events in human immunodeficiency virus-positive patients, five studies of ...

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Gastroesophageal hymenoptera stings add to causes of idiopathic anaphylaxis.

Annals of Allergy, Asthma and Immunology — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Stoevesandt J, Grundmeier N, Trautmann A PMID: 22289734 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Anaphylaxis following immunization rare

MedWire News - Pediatrics — Wed, 01 Feb 2012 00:00:00 +0100

Research suggests that anaphylaxis is a rare reaction to childhood immunizations. (Source: MedWire News - Pediatrics)

Allergy and sports in children

Pediatric Allergy and Immunology — Sun, 29 Jan 2012 11:08:48 +0100

To cite this article: Del Giacco SR, Carlsen K‐H, Du Toit G. Allergy and sports in children. Pediatric Allergy Immunol 2012: 23: 11–20.AbstractPhysical activity is beneficial for children with positive outcomes for mental and physical well‐being. Allergic conditions unique to the sporting arena may serve as an impediment to participation in physical activity for allergic children. A common example is exercise‐induced asthma; less common activity‐related allergic conditions include food‐dependent exercise‐induced anaphylaxis, exercise‐induced anaphylaxis, and exercise‐induced urticaria. Allergic children may also be at risk of allergic reactions when exposed to allergens that are more commonly found in the sports environment, e.g., latex, sports drinks, and medications suc...

Anaphylactic shock after vaccination 'extremely rare'

MedWire News - Pediatrics — Fri, 27 Jan 2012 06:16:11 +0100

Anaphylaxis is a very rare event following immunization, say researchers who detected no cases in a routine infant preschool immunization program that delivered more than 5.5 million vaccines. (Source: MedWire News - Pediatrics)

The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate based reactivity

Clinical and Experimental Allergy — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion and Clinical RelevanceThe glycosylated MRJP8 and MRJP9 of honeybee venom have IgE‐sensitizing potential in honeybee venom allergic patients beyond CCD reactivity and have to be considered as allergens, which might be potentially important for a fraction of venom allergic patients. They are valuable tools to elucidate individual component‐resolved reactivity profiles of venom allergic patients and to provide insights into the role of particular venom components. Due to their allergenic properties MRJP8 and MRJP9 were designated as isoallergens Api m 11.0101 and Api m 11.0201, respectively.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy)

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Shock in children after vaccination 'extremely rare'

Nursing Times Breaking News — Fri, 27 Jan 2012 00:00:00 +0100

Anaphylactic shock following vaccination is “extremely rare,” according to research by University Hospital Southampton NHS Foundation Trust, published online in the Archives of Disease in Childhood. (Source: Nursing Times Breaking News)

Anaphylaxis After Pediatric Immunization RareAnaphylaxis After Pediatric Immunization Rare

Medscape Today Headlines — Thu, 26 Jan 2012 22:13:25 +0100

In a new study, anaphylaxis was found to be rare after pediatric immunization, and nonexistent after routine infant and preschool immunization. Medscape Medical News (Source: Medscape Today Headlines)

Systemic mastocytosis complicating pregnancy.

Obstetrics and Gynecology — Thu, 26 Jan 2012 20:30:26 +0100

CONCLUSION: : Exacerbations of systemic mastocytosis during pregnancy can lead to significant maternal and fetal complications. Treatment with H1 blockers, and when indicated, steroids and epinephrine, can reduce these complications. PMID: 22270448 [PubMed - in process] (Source: Obstetrics and Gynecology)

Galactose-alpha-1,3-galactose Specific IgE is Associated with Anaphylaxis but not Asthma.

American Journal of Respiratory and Critical Care Medicine — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS: These results provide: i) a model of an ectoparasite-induced specific IgE response that can increase total serum IgE without creating a risk for asthma, and ii) further evidence that the main allergens that are causally related to asthma are those that are inhaled. PMID: 22281828 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Anaphylaxis is 'extremely rare', says study

Nursing in Practice — Tue, 24 Jan 2012 13:26:13 +0100

Anaphylactic shock following vaccination is “extremely rare”, a study has found read more (Source: Nursing in Practice)

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Serious Allergic Reactions Unlikely After Vaccination (CME/CE)

MedPage Today Allergy — Tue, 24 Jan 2012 13:01:00 +0100

(MedPage Today) -- Anaphylaxis following immunizations was a rare occurrence among children and teens in the U.K. and Ireland, researchers found. (Source: MedPage Today Allergy)

Kounis syndrome (allergic acute coronary syndrome): different views in allergologic and cardiologic literature

Internal and Emergency Medicine — Tue, 24 Jan 2012 06:55:15 +0100

Abstract The clinical picture of myocardial ischemia accompanying allergic reactions is defined in the cardiologic literature as Kounis syndrome (KS) or allergic angina/myocardial infarction. In PubMed, a search for “Kounis syndrome”, “allergic angina” or “allergic myocardial infarction” retrieves more than 100 results (among case reports, case series and reviews), most of which are published in cardiology/internal medicine/emergency medicine journals. In allergologic literature, heart involvement during anaphylactic reactions is well documented, but Kounis syndrome is hardly mentioned. Single case reports and small case series of angina triggered by allergic reactions have been reported for many years, and involvement of histamine and others mast cell mediators...

Folinic acid: Anaphylactic reaction in an elderly patient: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

Ranitidine: Anaphylaxis: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

Various drugs: Anaphylactic reactions: 15 case reports

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

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Intravenous iron therapy: how far have we come?

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Oral iron supplementation is usually the first choice for the treatment of iron deficiency anemia (IDA) because of its effectiveness and low cost. But unfortunately in many iron deficient conditions, oral iron is a less than the ideal treatment mainly because of adverse events related to the gastrointestinal tract as well as the long course required to treat anemia and replenish body iron stores. The first iron product for intravenous use was high-molecular-weight iron dextran. However, dextran-containing intravenous iron preparations are associated with an elevated risk of anaphylactic reactions, which made physicians reluctant to prescribe intravenous iron in the treatment of iron deficiency anemia for many years. In 1999 and 2001, two new intravenous iron preparations (ferric gluconate ...

Woman With Supposed Anaphylactic Reaction

Annals of Emergency Medicine — Fri, 20 Jan 2012 19:16:32 +0100

[Ann Emerg Med. 2012;59:98.] A 30-year-old woman was referred to the emergency department (ED) after presumably having had an anaphylactic reaction to cotrimoxazole tablets. In the ED, she was conscious, oriented, tachypneic, tachycardic, and hypotensive (systolic blood pressure of 60 mm Hg). She was fluid resuscitated; a central venous catheter was placed in the left internal jugular vein uneventfully, and an epinephrine infusion was started. A chest radiograph was obtained after line placement (). (Source: Annals of Emergency Medicine)

The Albumin in Subarachnoid Hemorrhage (ALISAH) Multicenter Pilot Clinical Trial: Safety and Neurologic Outcomes.

Stroke — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSIONS: Albumin in doses ranging up to 1.25 g/kg/day×7 days was tolerated by patients with subarachnoid hemorrhage without major complications and may be neuroprotective. Based on these results, planning of the ALISAH II, a Phase III, randomized, placebo-controlled trial to test the efficacy of albumin, is underway.Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT00283400. PMID: 22267829 [PubMed - as supplied by publisher] (Source: Stroke)

Incidence of anaphylaxis in the city of Alcorcon (Spain): a population‐based study

Clinical and Experimental Allergy — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion and Clinical RelevanceThis study revealed a higher rate of anaphylaxis than that in previous studies, although this incidence rate is probably lower than the real incidence rate. Studies exploring potential methodological, genetic and environmental factors accounting for these higher rates of anaphylaxis are required. (Source: Clinical and Experimental Allergy)

Fatal Infusion Reactions to Cetuximab: Role of Immunoglobulin E-Mediated Anaphylaxis [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

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Omalizumab beyond asthma.

Allergologia et Immunopathologia — Wed, 18 Jan 2012 05:00:00 +0100

CONCLUSION: There is not enough evidence to support the regular use of omalizumab in IgE diseases other than asthma. However, some experimental and clinical investigations indicate that omalizumab could be a therapeutic option in several allergic diseases like atopic dermatitis, urticaria, and eosinophilic gastrointestinal disorders. More control studies are needed in each IgE disease to evaluate the efficacy and safety of omalizumab in IgE mediated diseases. PMID: 22264640 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Cotrimoxazole: Anaphylactic reaction: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Cotrimoxazole: Anaphylaxis in a child, with subsequent desensitisation: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Gadopentetic acid: Anaphylactic reaction: 2 case reports

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Heparin: Anaphylaxis, with subsequent desensitisation

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

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Grass pollen allergy immunotherapy: Anaphylaxis: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Ibuprofen: Anaphylaxis?: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Immunoglobulin G: Anaphylaxis, with subsequent desensitisation: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Methocarbamol: Protracted anaphylaxis in an elderly patient: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Methotrexate: Anaphylaxis: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

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Moxifloxacin: Anaphylaxis in an elderly patient: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Pneumococcal vaccine: Anaphylaxis in a child: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Rifampicin/voriconazole interaction: Anaphylaxis, with subsequent desensitisation: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Royal jelly: Anaphylaxis: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Triamcinolone: Anaphylaxis following epidural administration: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

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Effects of Anemarrhena asphodeloides on IgE-mediated passive cutaneous anaphylaxis, compound 48/80-induced systemic anaphylaxis and mast cell activation.

Experimental and Toxicologic Pathology — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS: These results suggest that AAWE suppresses compound 48/80-induced mast cell activation by inhibition of cellular mechanisms in signaling pathways, and would be beneficial for treatment of mast cell-mediated anaphylactic response. PMID: 22261360 [PubMed - as supplied by publisher] (Source: Experimental and Toxicologic Pathology)

Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness.

Journal of Immunology — Mon, 16 Jan 2012 05:00:00 +0100

Authors: Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M Abstract We established a diphtheria toxin (DT)-based conditional deletion system using Il4 enhancer elements previously shown to be specific for IL-4 production in mast cells (MCs) or basophils (Mas-TRECK and Bas-TRECK mice). DT treatment of Bas-TRECK mice resulted in specific deletion of basophils, whereas both MCs and basophils were deleted in Mas-TRECK mice. DT-treated Mas-TRECK mice had impaired passive cutaneous anaphylaxis, IgE-mediated passive systemic anaphylaxis, and IgE-mediated chronic allergic inflammation, whereas DT-treated Bas-TRECK mice had impaired IgE-mediated chronic allergic inflammation. Using these m...

New NICE guidelines for suspected anaphylactic episodes

PharmacoEconomics and Outcomes News — Sun, 15 Jan 2012 04:11:42 +0100

(Source: PharmacoEconomics and Outcomes News)

Primary hydatid cyst in the soft tissue of the face: An exceptional occurrence

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Cherry Bansal, Nirupma Lal, RC Jain, AN Srivastava, Uroos FatimaIndian Journal of Dermatology 2011 56(6):768-770To emphasize that solitary hydatid cyst can be localized in the soft tissue and present as a soft tissue mass even in an unusual site like face, we report the case of a 42-year-old male patient presenting with a slowly growing mass in right temporal region. Computed tomography (CT) scan showed an encapsulated mass with multiple cysts. Histopathological examination revealed the characteristic findings, which were consistent with soft-tissue hydatid disease. In the absence of visceral organ involvement, this is the first reported case of a primary subcutaneous hydatid cyst in the skin of face in India. In the English literature, only one case of this kind has been reported till dat...

Severe anaphylactic reaction to atracurium

Indian Journal of Pharmacology — Sat, 14 Jan 2012 05:00:00 +0100

Amrita Gupta, Uma Srivastava, Avanish Saxena, Apurva Mittal, Yogita DwivediIndian Journal of Pharmacology 2012 44(1):144-145 (Source: Indian Journal of Pharmacology)

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Chlorhexidine: Anaphylaxis: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Influenza virus vaccine: Anaphylaxis in a child: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Ranitidine: Anaphylaxis in an elderly patient: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Anaphylaxis to atracurium – a non‐QAI‐dependent reaction?

Acta Anaesthesiologica Scandinavica — Fri, 13 Jan 2012 12:12:36 +0100

(Source: Acta Anaesthesiologica Scandinavica)

MHRA reminds of potential for hypersensitivity with chlorhexidine

NeLM - News — Fri, 13 Jan 2012 05:00:00 +0100

Source: MHRA Area: News This 'Stop Press' article published in the January 2012 issue of Drug Safety Update from the MHRA reminds healthcare professionals that chlorhexidine is known to induce hypersensitivity (including generalised allergic reactions and anaphylactic shock) and that products or medical devices containing chlorhexidine should not be administered to anyone with a possible history of an allergic reaction to chlorhexidine. The prevalence of chlorhexidine hypersensitivity is unknown, but it is likely to be rare. (Source: NeLM - News)

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D.F. Stauffer Biscuit Co., Inc. Issues Allergy Alert and Voluntary Recall on Safeway Snack Artist Sugar Free Bite-Sized Chocolate Chip Cookies Due to Mislabeling and Undeclared Allergens

Food and Drug Administration — Wed, 11 Jan 2012 18:52:00 +0100

D. F. Stauffer Biscuit Co., Inc. is voluntarily recalling one specific lot of Safeway Snack Artist Sugar Free Bite-Sized Chocolate Chip Cookies because they contain undeclared milk and eggs. People with an allergy or severe sensitivity to milk or eggs run the risk of serious or life-threatening allergic reactions if they consume this product. Symptoms may include itching, hives, wheezing, vomiting, anaphylaxis and digestive problems, such as bloating, gas or diarrhea. (Source: Food and Drug Administration)

Management of acute allergic reactions by dispatching physicians in a Medical Emergency Dispatch Centre

Emergency Medicine Journal — Wed, 11 Jan 2012 05:00:00 +0100

Conclusions Only moderate agreement is highlighted between the initial severity assessed by the dispatching physician and the final severity assessed by the physician later examining the patient. This demonstrates the need to develop a tool for assessing severity of acute allergic reactions for dispatching physicians in Medical Emergency Dispatch Centres. (Source: Emergency Medicine Journal)

Evaluation of particle gel immunoassays for the detection of severe immunoglobulin A deficiency and anti-human immunoglobulin A antibodies.

Transfusion — Mon, 09 Jan 2012 05:00:00 +0100

CONCLUSIONS: The ID-PaGIA IgA deficiency test was a sensitive and specific tool for identifying IgA SD donors or patients. Sensitivity of the Ab test was high for donors but reduced for patients and of high specificity in both groups. Further studies with patients are needed to confirm this latter observation. Implementation of these tests would make it possible to supply appropriate products from IgA SD donors to prevent anaphylactic transfusion reactions in patients. PMID: 22229448 [PubMed - as supplied by publisher] (Source: Transfusion)

Skin Reactions on Exposure to the Pine Processionary Caterpillar (Thaumetopoea pityocampa).

Actas Dermo-Sifiliograficas — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Vega J, Vega JM, Moneo I Abstract The pine processionary caterpillar is the larval form of the Thaumetopoea pityocampa moth. Mediterranean forests regularly suffer plagues of this insect, which has been moving north as a result of global warming. When the small urticating hairs that develop during the last 3 larval stages are shed and can become airborne. If they come in contact with skin, they can cause a variety of reactions, notably contact urticaria and papular rashes. Irritation can also occur if the hairs lodge in the mucosa of the conjunctiva or in the respiratory tract. Several cases of anaphylactic reactions have been reported in recent years. Mechanical (irritative) mechanisms may be involved in the pathogenesis of lesions, or immunoglobulin E-mediated allergic h...

Inhibitory Effects of Water-Soluble Low-Molecular-Weight β-(1,3-1,6) D-Glucan Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast on Mast Cell Degranulation and Passive Cutaneous Anaphylaxis.

Bioscience, Biotechnology, and Biochemistry — Sat, 07 Jan 2012 05:00:00 +0100

We examined whether LMW-β-glucan could inhibit mast cell degranulation and passive cutaneous anaphylaxis (PCA). LMW-β-glucan dose-dependently inhibited the degranulation of both rat basophilic leukemia (RBL-2H3) and cultured mast cells (CMCs) activated by calcium ionophore A23187 or IgE. However, LMW-β-glucan had no cytotoxicity towards RBL-2H3 cells and CMCs. Furthermore, orally administered LMW-β-glucan inhibited the IgE-induced PCA reaction in mice. These results show LMW-β-glucan to be a possible compound for the effective therapeutic treatment of allergic diseases. PMID: 22232243 [PubMed - as supplied by publisher] (Source: Bioscience, Biotechnology, and Biochemistry)

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Adverse events following immunization during mass vaccination campaigns at first introduction of a meningococcal A conjugate vaccine in Burkina Faso, 2010.

Vaccine — Fri, 06 Jan 2012 05:00:00 +0100

We report on the monitoring of adverse events following immunization (AEFI) in Burkina Faso where more than 11 million people aged 1-29years were vaccinated. Vaccine pharmacovigilance relied on stimulated passive AEFI surveillance countrywide and active surveillance for 12 clinical conditions in one sentinel district (Ziniaré) with 97,715 people eligible for vaccination. All AEFI occurring during the 10days of mass campaign or the 42 subsequent days were to be notified. Serious AEFI were submitted to a national expert committee (NEC) for causality assessment. A total of 11,466,950 people were vaccinated with 1471 vaccines reported to have experienced at least one AEFI (12.83 cases per 100,000). 1444 AEFI were minor; the most common of which were fever, headache, gastro-intestinal disorder...

Anaphylaxis Triggered by Benzyl Benzoate in a Preparation of Depot Testosterone Undecanoate

Advances in Pharmacological Sciences — Thu, 05 Jan 2012 14:27:21 +0100

We report the first case of an anaphylactic reaction to Reandron 1000 (depot testosterone undecanoate with a castor oil and benzyl benzoate vehicle). While considered to have a favourable safety profile, serious complications such as oil embolism and anaphylaxis can occur. In our patient, skin testing identified benzyl benzoate to be the trigger, with no reaction to castor oil or testosterone undecanoate components. As benzyl benzoate exists in multiple pharmaceuticals, foods, and cosmetics, individual components of pharmaceuticals should be tested when investigating drug allergies. Doctors should be alert to the potential for serious reactions to any of the components of Reandron 1000. (Source: Advances in Pharmacological Sciences)

An Intervention to Increase High School Students' Compliance With Carrying Auto-Injectable Epinephrine: A MASNRN Study.

The Journal of School Nursing — Wed, 04 Jan 2012 05:00:00 +0100

Authors: Spina JL, McIntyre CL, Pulcini JA Abstract Adolescents with life-threatening allergies are at a greater risk for a fatal anaphylactic event since only about half of them carry unexpired epinephrine available for emergency use. The aim of this study was to test the effectiveness of school nurse interventions that consisted of either routine or periodic checks during the school year for the availability of unexpired auto-injectable epinephrine. Seventy-seven students from 11 Massachusetts high schools participated in this study. Descriptive and chi-square (χ(2)) statistics as well as the Fisher's exact test were used to analyze data. Findings suggest that while periodic checks for the availability of epinephrine throughout the school year do not increase the likelihood that...

A systematic review of validated methods for identifying anaphylaxis, including anaphylactic shock and angioneurotic edema, using administrative and claims data

Pharmacoepidemiology and Drug Safety — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionsResearch needs to be conducted on designing validation studies to test anaphylaxis algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

A systematic review of validated methods for identifying hypersensitivity reactions other than anaphylaxis (fever, rash, and lymphadenopathy), using administrative and claims data

Pharmacoepidemiology and Drug Safety — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionsThe ability of coding algorithms to identify hypersensitivity reactions varied, with decreasing performance occurring with expanded outcome definitions. This examination of hypersensitivity‐reaction coding algorithms provides an example of surveillance bias resulting from outcome definitions that include mild cases. Data mining may provide tools for algorithm development for hypersensitivity and other health outcomes. Research needs to be conducted on designing validation studies to test hypersensitivity‐reaction algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

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A systematic review of validated methods for identifying acute respiratory failure using administrative and claims data

Pharmacoepidemiology and Drug Safety — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionsResearch needs to be conducted on designing validation studies to test ARF algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Electronic healthcare databases for active drug safety surveillance: is there enough leverage?

Pharmacoepidemiology and Drug Safety — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionActive surveillance using healthcare data‐based networks for signal detection is feasible, although the leverage to do so may be low for infrequently used drugs and for rare outcomes. Extending database network size to include data from heterogeneous populations and increasing follow‐up time are warranted to maximize leverage of these surveillance systems. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

The ability of adults and children to visually identify peanuts and tree nuts.

Annals of Allergy, Asthma and Immunology — Fri, 30 Dec 2011 11:43:01 +0100

CONCLUSIONS: Overall, both children and adults are unreliable at visually identifying most nuts. Treatment of nut allergies with dietary avoidance should include education for both adults and children on identification of peanuts and tree nuts. PMID: 22192961 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Allergy Testing in Childhood: Using Allergen-Specific IgE Tests

PEDIATRICS — Fri, 30 Dec 2011 05:00:00 +0100

A variety of triggers can induce common pediatric allergic diseases which include asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis. Allergy testing serves to confirm an allergic trigger suspected on the basis of history. Tests for allergen-specific immunoglobulin E (IgE) are performed by in vitro assays or skin tests. The tests are excellent for identifying a sensitized state in which allergen-specific IgE is present, and may identify triggers to be eliminated and help guide immunotherapy treatment. However, a positive test result does not always equate with clinical allergy. Newer enzymatic assays based on anti-IgE antibodies have supplanted the radioallergosorbent test (RAST). This clinical report focuses on allergen-specific IgE testing, emphasizing that the m...

Anaphylaxis in an infant caused by menthol-containing cologne.

Allergologia et Immunopathologia — Fri, 30 Dec 2011 05:00:00 +0100

Authors: Arikan-Ayyildiz Z, Akgül F, Yılmaz S, Ozdemir D, Uzuner N PMID: 22209027 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial

Journal of Allergy and Clinical Immunology — Fri, 30 Dec 2011 05:00:00 +0100

Conclusion: Reslizumab significantly reduced intraepithelial esophageal eosinophil counts in children and adolescents with eosinophilic esophagitis. However, improvements in symptoms were observed in all treatment groups and were not associated with changes in esophageal eosinophil counts. (Source: Journal of Allergy and Clinical Immunology)

Anaphylaxis and Reactions to Foods in Children ‐ A population based case study of emergency department visits

Clinical and Experimental Allergy — Wed, 28 Dec 2011 05:00:00 +0100

Conclusions & Clinical RelevanceReactions to peanut and tree nuts are as common as reactions to milk and egg in early life. Concomitant exposure to airborne allergens seems to increase the risk of anaphylaxis to foods. Among children with anaphylaxis, wheeze is prevalent even in children without asthma diagnosis.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy)

Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients.

Human Immunology — Wed, 28 Dec 2011 05:00:00 +0100

Authors: Wang S, Delgado JC, Ravkov E, Eckels DD, Georgelas A, Pavlov IY, Cusick M, Sebastian K, Gleich GJ, Wagner LA Abstract Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients and 20 negative control subjects were recruited and evaluated on the basis of history, skin prick testing, specific immunoglobulin E (IgE) levels, and peripheral blood mononuclear cell proliferation in response to shrimp tropomyosin or shrimp tropomyosin-derived peptides. Of the classically allergic patients by history, 59%tested positive for ser...

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2011

Journal of Allergy and Clinical Immunology — Tue, 27 Dec 2011 23:54:41 +0100

This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2011. Food allergy appears to be increasing in prevalence and carries a strong economic burden. Risk factors can include dietary ones, such as deficiency of vitamin D and timing of complementary foods, and genetic factors, such as filaggrin loss-of-function mutations. Novel mechanisms underlying food allergy include the role of invariant natural killer T cells and influences of dietary components, such as isoflavones. Among numerous preclinical and clinical treatment studies, promising observations include the efficacy of sublingual and oral immunotherapy, a Chinese herbal remedy showing promising in v...

Rice-Induced Anaphylaxis: IgE-Mediated Allergy against a 56-kDa Glycoprotein

International Archives of Allergy and Immunology — Tue, 27 Dec 2011 23:00:00 +0100

Int Arch Allergy Immunol 2012;158:9–17 (DOI:10.1159/000330641) (Source: International Archives of Allergy and Immunology)

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Food Allergy Guidelines and Beyond

Immunology and Allergy Clinics of North America — Mon, 26 Dec 2011 05:00:00 +0100

Allergic reactions to milk were first described by Hippocrates more than two thousand years ago; however, it is only in the past two decades that food allergy has emerged as an important public health problem affecting people of all ages in societies with a western lifestyle, such as US, Canada, UK, Australia, and Western Europe. The overall prevalence of food allergy increased by 18% from 1997 to 2007 in US children. In particular, peanut allergy tripled over the similar period in the US, Canada, UK, and Australia. Eosinophilic esophagitis (EoE) epidemics have been recognized in children and adults in the past decade; diagnosis of food allergy in EoE is especially challenging due to the lack of a noninvasive diagnostic test. Food allergy is the most common cause of the anaphylaxis in the ...

[Fast recovery of haemodynamic and ventilatory functions after sugammadex bolus following rocuronium-induced anaphylactic shock refractory to conventional treatment.]

Annales Francaises d'Anesthesie et de Reanimation — Fri, 23 Dec 2011 05:00:00 +0100

We report a new case of severe anaphylactic reaction to rocuronium treated with sugammadex. After 18minutes of conventional treatment because of persistent cardiocirculatory failure and bronchospasm, a bolus of 2000mg (18mg/kg) of sugammadex was injected. This was associated with rapid correction of arterial hypotension and bronchoconstriction. The underlying pathophysiological mechanisms that explain the potential beneficial effect of sugammadex in this context are unknown but it is important to know that refractory anaphylactic shock to rocuronium can be potentially corrected with sugammadex. PMID: 22197044 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

Blood — Thu, 22 Dec 2011 05:00:00 +0100

It has been reported that the intracellular antiapoptotic factor myeloid cell leukemia sequence 1 (Mcl-1) is required for mast cell survival in vitro, and that genetic manipulation of Mcl-1 can be used to delete individual hematopoietic cell populations in vivo. In the present study, we report the generation of C57BL/6 mice in which Cre recombinase is expressed under the control of a segment of the carboxypeptidase A3 (Cpa3) promoter. C57BL/6-Cpa3-Cre; Mcl-1fl/fl mice are severely deficient in mast cells (92%-100% reduced in various tissues analyzed) and also have a marked deficiency in basophils (58%-78% reduced in the compartments analyzed), whereas the numbers of other hematopoietic cell populations exhibit little or no changes. Moreover, Cpa3-Cre; Mcl-1fl/fl mice exhibited marked reduc...

The use of adrenaline autoinjectors by children and teenagers

Clinical and Experimental Allergy — Mon, 19 Dec 2011 05:00:00 +0100

Conclusions and Clinical RelevanceAdrenaline is used by only a minority of patients experiencing anaphylaxis in the community. Thirteen of the 41 patients with anaphylaxis who used their autoinjector needed another dose of adrenaline. Further research is needed to consider how to best encourage the usage of adrenaline when clinically indicated in anaphylaxis. (Source: Clinical and Experimental Allergy)

Isosulfan blue-induced anaphylactic reaction during sentinel lymph node biopsy in breast cancer.

Breast — Mon, 19 Dec 2011 05:00:00 +0100

Authors: Cinar H, Koca B, Kesicioglu T, Karabulut K, Karabicak I, Polat C, Tur AH PMID: 22186354 [PubMed - as supplied by publisher] (Source: Breast)

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Use of sublingual tacrolimus in lung transplant recipients

The Journal of Heart and Lung Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Conclusions: Tacrolimus administered sublingually at approximately half of the oral dose achieves therapeutic blood concentrations and is safe in LTRs. Delivery via the sublingual route using this conversion ratio may aid clinicians in maintaining therapeutic tacrolimus blood concentrations while avoiding the need for intravenous administration. (Source: The Journal of Heart and Lung Transplantation)

Negative predictive value of skin tests to neuromuscular blocking agents

Allergy — Fri, 16 Dec 2011 05:00:00 +0100

We present a series of 49 patients with confirmed allergy to NMBAs, six of whom required a subsequent surgery with neuromuscular blockade. Negative skin tests allowed the selection of an alternative NMBA, which was well tolerated in all 6 cases. We found an excellent negative predictive value of skin tests in our series but larger studies are required to properly address this question. (Source: Allergy)

Eating Their Way To Adulthood

Psychology Today Food and Diet Center — Thu, 15 Dec 2011 18:11:10 +0100

Ever since my second child Eden had his initial life threatening allergic (anaphylactic) reaction to the otherwise wholesome lunch I prepared for him (organic ground meat, rice, and a sliced banana set aside for a dessert that never materialized since we were in the ER by then) I've prioritized "Food Safety" in uppercase lettering. Primary Topic: Parenting read more (Source: Psychology Today Food and Diet Center)

Summary: International Kidney Cancer Symposium

Kidney Cancer Association — Thu, 15 Dec 2011 16:51:59 +0100

Conclusions: Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR. No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question for this presentation was: is there a future for robotic PN? At Society of Urologic Oncology (SUO) 2007 meeting there ...

Hot Water Extract of Adzuki (Vigna angularis) Suppresses Antigen‐Stimulated Degranulation in Rat Basophilic Leukemia RBL‐2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice

Phytotherapy Research — Thu, 15 Dec 2011 05:00:00 +0100

In this study, we fractionated HWEA to 4 fractions using stepwise gradient column chromatography with water and ethanol, and demonstrated the effects of each fraction on antigen (Ag)‐stimulated degranulation in rat basophilic leukemia RBL‐2H3 cells. The 40% ethanol eluate extract (EtEx.40) showed the strongest inhibition level of these fractions. To reveal the inhibitory mechanisms underlying degranulation by EtEx.40, we investigated intracellular reactive oxygen species (ROS) production, intracellular free Ca2+ concentration ([Ca2+]i), and early intracellular signaling pathways. Treatment with EtEx.40 markedly inactivated Lyn following Ag stimulation, resulting in the suppressions of intracellular elevation of [Ca2+]i and production of ROS. To identify the active compound in EtEx.40, ...

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CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI‐dependent anaphylactic degranulation

Cytometry Part B: Clinical Cytometry — Thu, 15 Dec 2011 05:00:00 +0100

Conclusion.CD300a is expressed on human peripheral blood basophils and rapidly up‐regulated upon cross‐linking of IgE/FcεRI and suppresses anaphylactic degranulation. © 2011 International Clinical Cytometry Society (Source: Cytometry Part B: Clinical Cytometry)

Impact of Age and Heterophilic Interference on the Basal Serum Tryptase, a Risk Indication for Anaphylaxis, in 1,092 Dermatology Patients.

Acta Dermato-Venereologica — Thu, 15 Dec 2011 05:00:00 +0100

In conclusion, older patients showed significantly higher serum tryptase levels and heterophilic interference was of subordinate relevance. PMID: 22170044 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

The Epidemiology of IgE-Mediated Food Allergy and Anaphylaxis

Immunology and Allergy Clinics of North America — Thu, 15 Dec 2011 05:00:00 +0100

The rise in food allergy prevalence in developed countries is evident from anecdotal reports but has been difficult to document and until recently good quality prevalence data were lacking. Although most emerging risk factors seem related to the “modern lifestyle” the reasons for the rise in food allergy prevalence remain poorly understood. The incidence of food allergy–related anaphylaxis is rising particularly in children younger than 5 years of age. Emerging studies are better designed to assess the true prevalence of IgE-mediated food allergy using formal population sampling frames, standardized and objective outcome data including use of the gold standard oral food challenge, and the capacity to adjust for potential selection bias. (Source: Immunology and Allergy Clinics of Nort...

NICE issues costing statement on its guidance for anaphylaxis

NeLM - News — Wed, 14 Dec 2011 05:00:00 +0100

Source: NICE Area: News The National Institute for Health and Clinical Excellence (NICE) has issued a costing template to accompany its guidance (CG134) on the care of adults, young people and children following emergency treatment for suspected anaphylaxis. The costing statement suggests that there is likely to be wide variation in current practice nationally, so it is not possible to calculate a national resource impact of the recommendations with a reasonable degree of certainty. Potential areas for additional costs are: - Additional referrals to specialist allergy services. Potential areas for savings are: - Reduced emergency treatments required for anaphylactic reactions. - Avoiding unnecessary appointments with...

Prevalence of food allergy among preschool children in northern Thailand

Pediatrics International — Wed, 14 Dec 2011 05:00:00 +0100

Conclusions: This study found at least 1.11% (95%CI 0.41‐2.98%) prevalence of IgE‐mediated FA confirmed by OFC. The most commonly causative food was shrimp. Ant eggs were a unique food allergen causing severe reactions in our preschool children. (Source: Pediatrics International)

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NICE issues clinical guideline on assessment and referral following emergency treatment for an anaphylactic episode

NeLM - Guidelines — Wed, 14 Dec 2011 05:00:00 +0100

Source: NICE Area: Evidence > Guidelines NICE has published a clinical guideline (CG134) offering evidence-based advice on the care of adults, young people and children following emergency treatment for suspected anaphylaxis. Please follow link for further details. (Source: NeLM - Guidelines)

Can patients with peanut allergy take calcium and vitamin D supplements?

NeLM - Medicines Q and A — Tue, 13 Dec 2011 05:00:00 +0100

Source: Wessex Drug and Medicines Information Centre Area: Evidence > Medicines Q & A Soya oil may be used as a carrier for vitamin D in some calcium and vitamin D supplements. As peanut and soya belong to the same plant family (legumes), concern has been raised that patients allergic to peanuts might also be allergic to soya. There is no consistent published advice on the risk of cross-sensitivity, and further studies are required to quantify the risk. Current specialist advice is that patients who are allergic to peanuts are not usually advised to avoid soya, because the clinical significance of cross-reactivity is not completely clear. These patients almost certainly eat soya without realising it as it is such a common part of the diet. Soya should...

Anaphylaxis to dye during breast surgery

Anaesthesia — Tue, 13 Dec 2011 00:52:47 +0100

(Source: Anaesthesia)

Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile

Allergy — Mon, 12 Dec 2011 23:47:30 +0100

To cite this article: Calderón MA, Simons FER, Malling H‐J, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02761.xAbstractAllergen immunotherapy reorients inappropriate immune responses in allergic patients. Sublingual allergen immunotherapy (SLIT) has been approved, notably in the European Union, as an effective alternative to subcutaneous allergen immunotherapy (SCIT) for allergic rhinitis patients. Compared with SCIT, SLIT has a better safety profile. This is possibly because oral antigen‐presenting cells (mostly Langerhans and myeloid dendritic cells) exhibit a tolerogenic phenotype, despite constant exposure to danger signals from food and microbes. This...

Close-up of the {alpha}-Gal Epitope [Glycobiology and Extracellular Matrices]

Journal of Biological Chemistry — Fri, 09 Dec 2011 05:00:00 +0100

Anaphylaxis mediated by carbohydrate structures is a controversially discussed phenomenon. Nevertheless, IgE with specificity for the xenotransplantation antigen α1,3-Gal (α-Gal) are associated with a delayed type of anaphylaxis, providing evidence for the clinical relevance of carbohydrate epitopes in allergy. The aim of this study was to dissect immunoreactivity, interaction, and fine epitope of α-Gal-specific antibodies to obtain insights into the recognition of carbohydrate epitopes by IgE antibodies and their consequences on a molecular and cellular level. The antigen binding moiety of an α-Gal-specific murine IgM antibody was employed to construct chimeric IgE and IgG antibodies. Reactivity and specificity of the resulting antibodies were assessed by means of ELISA and receptor b...

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Successful management of rocuronium-induced anaphylactic reactions with sugammadex: a case report

Journal of Clinical Anesthesia — Thu, 08 Dec 2011 05:00:00 +0100

Abstract: Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis. (Source: Journal of Clinical Anesthesia)

Wheat gliadins modified by deamidation are more efficient than native gliadins in inducing a Th2 response in Balb/c mice experimentally sensitized to wheat allergens

Nahrung / Food — Wed, 07 Dec 2011 05:00:00 +0100

Conclusions: DG can sensitize mice much more efficiently than NG. Moreover, this mouse model of allergy to DG revealed an IgE reactivity pattern against purified gliadins which was very similar to that of DG‐allergic patients. (Source: Nahrung / Food)

Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm.

Cellular and Molecular Life Sciences : CMLS — Wed, 07 Dec 2011 05:00:00 +0100

Authors: Manikandan J, Kothandaraman N, Hande MP, Pushparaj PN Abstract Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special ...

[Peroperative anaphylactic shock in children: Management and evaluation.]

Annales Francaises d'Anesthesie et de Reanimation — Tue, 06 Dec 2011 05:00:00 +0100

Authors: Lucas-Polomeni MM, Rochefort-Morel C, Delaval Y Abstract Anaphylactic shock is the most severe manifestation of hypersensitivity, whether of allergic origin or not. In the operating theatre, anaphylactic shock is rare in paediatric patients and latex allergy is still the major cause of allergy. Whatever the cause and mechanism of the reaction, its treatment should be started as early as possible: a high level of suspicion is thus necessary to establish a diagnosis as early as possible. Symptomatic treatment is well codified. The results of blood sampling at the time of the reaction and of allergic tests performed a few weeks later will enable a definitive diagnosis to be made and appropriate recommendations (medical alert card) to be given to the patients and its parents. ...

Influence of the Chungkookjang on histamine-induced wheal and flare skin response: a randomized, double-blind, placebo controlled trial

BMC Complementary and Alternative Medicine — Mon, 05 Dec 2011 05:00:00 +0100

This study will show the potential anti-inflammatory properties of the CKJ in their skin activity when histamine is the challenging agent as occurs in the clinical situation. And the present protocol will confirm the efficacy and safety of the CKJ for allergy symptoms, suggesting more basic knowledge to conduct further randomized controlled trials (RCT). If this study will be successfully performed, the CKJ will be an alternative dietary supplemental remedy for allergy patients.Trial registration: NCT01402141 (Source: BMC Complementary and Alternative Medicine)

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High rates of perinatal Group B Streptococcus clindamycin and erythromycin resistance in an Upstate NY hospital.

Antimicrobial Agents and Chemotherapy — Mon, 05 Dec 2011 05:00:00 +0100

CONCLUSION:Rates of GBS resistance to clindamycin and erythromycin are much higher than reported in earlier US studies, suggesting both increasing resistance as well as regional variation in resistance. These findings lend strong support to the CDC and ACOG recommendations that clindamycin use for intrapartum antibiotic prophylaxis be restricted to penicillin allergic women at high risk of anaphylaxis and that GBS isolates be tested for antibiotic resistance prior to the use of clindamycin in these women. PMID: 22143529 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Managing the Student With Severe Food Allergies.

The Journal of School Nursing — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Robinson JM, Ficca M Abstract School nurses play a key role in managing students with food allergies. It is becoming more common to encounter students with severe allergies to multiple foods, putting them at risk for anaphylaxis. It is essential that the school nurse have a clear understanding of food allergies and how to effectively manage students in the school setting. Effective communication between families, health care providers, faculty, staff, and students, is of utmost importance when developing a plan of care to ensure the safety of the student with food allergies. Using an interdisciplinary approach to case management, the school nurse can develop comprehensive individualized health care plans for all students with food allergies. PMID: 22147836 [PubMed - as...

Inadvertent exposures in children with peanut allergy

Pediatric Allergy and Immunology — Sun, 04 Dec 2011 05:00:00 +0100

Conclusion: The annual incidence rate of accidental exposure for children with peanut allergy is 12.5%. Children with a recent diagnosis and adolescents are at higher risk. Hence, education of allergic children and their families is crucial immediately after diagnosis and during adolescence. As many reactions were treated inappropriately, healthcare professionals require better education on anaphylaxis management. (Source: Pediatric Allergy and Immunology)

Monitoring honeybee venom immunotherapy in children with the basophil activation test

Pediatric Allergy and Immunology — Sun, 04 Dec 2011 05:00:00 +0100

Conclusion: Basophil CD63 allergen–specific sensitivity seems to be a promising tool for monitoring protective immune response in honeybee VIT. (Source: Pediatric Allergy and Immunology)

Management of Multiple Drug Allergies in Children

Current Allergy and Asthma Reports — Fri, 02 Dec 2011 18:08:40 +0100

Abstract Children with multiple drug allergies are likely to require treatment with one or more of the drugs to which they may have had a reaction, when there is no alternate effective drug available. Detailed review of their history and/or use of appropriate diagnostic studies will help determine the potential safety of readministering the desired drug as well as the method for its readministration, most likely in the form of a drug challenge or desensitization. A practical approach to the diagnosis and treatment of children with multiple drug allergies is described in this review. Content Type Journal ArticleCategory Anaphylaxis and Drug Allergy (P Lieberman and S Spector, Section Editors)Pages 1-6DOI 10.1007/s11882-011-0239-yAuthors Anahita Falakshahi Dioun, Childr...

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Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy

Journal of Clinical Investigation — Fri, 02 Dec 2011 08:01:27 +0100

IgE-mediated activation of mast cells and basophils underlies allergic diseases such as asthma. Histamine-releasing factor (HRF; also known as translationally controlled tumor protein [TCTP] and fortilin) has been implicated in late-phase allergic reactions (LPRs) and chronic allergic inflammation, but its functions during asthma are not well understood. Here, we identified a subset of IgE and IgG antibodies as HRF-interacting molecules in vitro. HRF was able to dimerize and bind to Igs via interactions of its N-terminal and internal regions with the Fab region of Igs. Therefore, HRF together with HRF-reactive IgE was able to activate mast cells in vitro. In mouse models of asthma and allergy, Ig-interacting HRF peptides that were shown to block HRF/Ig interactions in vitro inhibited IgE/H...

Chlorhexidine: Anaphylaxis in an elderly patient: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

(Source: Reactions)

Characterization of a Par j 1/Par j 2 mutant hybrid with reduced allergenicity for immunotherapy of Parietaria allergy

Clinical and Experimental Allergy — Thu, 01 Dec 2011 05:00:00 +0100

Conclusion:Our results demonstrated that a mutant hybrid expressing genetically engineered forms of the major P.judaica allergens displayed reduced allergenicity and retained T cell reactivity for the induction of protective antibodies in vaccination approaches for the treatment of Parietaria pollinosis.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy)

Inhibitory effect of Lactobacillus plantarum K-1 on passive cutaneous anaphylaxis reaction and scratching behavior in mice.

Archives of Pharmacal Research — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Jang SE, Trinh HT, Chung YH, Han MJ, Kim DH Abstract Lactobacillus plantarum K-1 (LP) inhibiting AP-1 (c-Jun) and NF-κB activations was isolated from kimchi, and its inhibitory activity against scratching behavior and passive cutaneous anaphylaxis reaction in mice was investigated. Heat-inactivated LP (heated at 60°C for 30 min) potently inhibited the expression of TNF-α and IL-4 as well as the activation of their transcription factors, NF-κB and c-jun, in phorbol 12'-myristate 13'-acetate-stimulated RBL-2H3 cells. LP (1 ×10(10) CFU per mouse) showed a potent inhibition against passive cutaneous anaphylaxis reaction induced by the IgE-antigen complex in mice, inhibiting it by 87.5%. LP (1 × 10(10) CFU/mouse) inhibited histamine-induced scratching behavior by 58.9% co...

The safety and efficacy of sublingual and oral immunotherapy for milk allergy

Journal of Allergy and Clinical Immunology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusion: OIT was more efficacious for desensitization to CM than SLIT alone but was accompanied by more systemic side effects. Clinical desensitization was lost in some cases within 1 week off therapy. (Source: Journal of Allergy and Clinical Immunology)

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Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock.

Journal of Leukocyte Biology — Wed, 30 Nov 2011 05:00:00 +0100

Authors: Tanaka Y, Nagai Y, Kuroishi T, Endo Y, Sugawara S Abstract Previously, two anti-Ly-6G mAb-RB6-8C5 and 1A8-have been used to deplete neutrophils in mice and to clarify their involvement in immune responses. During the course of experiments on neutrophil depletion, we noticed that i.v. injection of RB6-8C5 or 1A8 induced anaphylaxis-like shock in mice pretreated i.v. with LPS. Signs of shock, such as hypothermia, appeared within a few minutes, and the mice died of shock within 20 min of the antibody injection. In vivo experiments, including depletion of various cell types, indicated that neutrophils and macrophages (but not platelets, basophils, or mast cells) are involved in the shock. Experiments using various drugs and gene-targeted mice demonstrated that PAF is the centr...

Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells

Cancer Immunology, Immunotherapy — Wed, 30 Nov 2011 04:53:05 +0100

Abstract Breast and ovarian cancer are two of the leading causes of cancer deaths among women in the United States. Overexpression of the HER2/neu oncoprotein has been reported in patients affected with breast and ovarian cancers, and is associated with poor prognosis. To develop a novel targeted therapy for HER2/neu expressing tumors, we have constructed a fully human IgE with the variable regions of the scFv C6MH3-B1 specific for HER2/neu. This antibody was expressed in murine myeloma cells and was properly assembled and secreted. The Fc region of this antibody triggers in vitro degranulation of rat basophilic cells expressing human FcεRI (RBL SX-38) in the presence of murine mammary carcinoma cells that express human HER2/neu (D2F2/E2), but not the shed (soluble) antigen...

ACE Inhibitor–Induced Angioedema

Current Allergy and Asthma Reports — Wed, 30 Nov 2011 04:52:45 +0100

Abstract Much has been written about hereditary angioedema (HAE) in recent literature; however, the prevalence of angiotensin-converting enzyme inhibitor–induced angioedema (ACEiIA) far exceeds that of HAE. Similarly, multiple therapies have been developed for HAE, yet no definitive therapy is available for ACEiIA. In this article, we discuss the mechanism, prevalence, pathophysiology, and management of ACEiIA, with focus on newer therapies recently approved for HAE and how they may be effective for ACEiIA. Content Type Journal ArticleCategory Anaphylaxis and Drug Allergy (P Lieberman and S Spector, Section Editors)Pages 1-7DOI 10.1007/s11882-011-0238-zAuthors Monali Vasekar, Department of Medicine, Penn State University, 500 University Drive, Hershey, PA 17033, USAT...

The Likelihood of Remission of Food Allergy in Children: When Is the Optimal Time for Challenge?

Current Allergy and Asthma Reports — Mon, 28 Nov 2011 16:55:22 +0100

Abstract Although diagnostic testing methods for food hypersensitivity have improved over time, both in vivo and in vitro methods are significantly flawed, especially as evidenced by the frequent occurrence of false-positive test results. Because of these limitations, oral food challenge testing remains an essential element in the diagnosis and management of food allergy. In fact, the double-blind, placebo-controlled food challenge remains the gold standard for the diagnosis of food allergy. In this review, we focus on the optimal timing of oral food challenges, especially for patients with a known food allergy, to determine if the food allergy may have been outgrown. Content Type Journal ArticleCategory Anaphylaxis and Drug Allergy (P Lieberman and S Spector, Section ...

Adverse events induced by ceftriaxone: a 10‐year review of reported cases to Iranian Pharmacovigilance Centre

Journal of Clinical Pharmacy and Therapeutics — Mon, 28 Nov 2011 05:00:00 +0100

Conclusion: Severe and life‐threatening adverse reactions induced by ceftriaxone are of great concern. Rapid intravenous injection, unlabelled use and previous patient history of allergic reactions to cephalosporins or penicillins are risk factors that should be guarded against. (Source: Journal of Clinical Pharmacy and Therapeutics)

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Laboratory diagnosis of acute anaphylaxis

Clinical and Experimental Allergy — Thu, 24 Nov 2011 23:44:53 +0100

(Source: Clinical and Experimental Allergy)

Severe Life-Threatening or Disabling Anaphylaxis in Patients with Systemic Mastocytosis: A Single-Center Experience

International Archives of Allergy and Immunology — Thu, 24 Nov 2011 23:00:00 +0100

Int Arch Allergy Immunol 2012;157:399–405 (DOI:10.1159/000329218) (Source: International Archives of Allergy and Immunology)

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood-brain barrier damage and brain oedema independently of infarct size

Journal of Neuroinflammation — Thu, 24 Nov 2011 05:00:00 +0100

Conclusions: Our results suggest that systemic inflammatory conditions induce cerebrovascular inflammation via diverse mechanisms. Increased brain inflammation, blood-brain barrier injury and brain oedema formation can be major contributors to impaired outcome in mice after experimental stroke with systemic inflammatory stimuli, independently of infarct size. (Source: Journal of Neuroinflammation)

Anaphylactic Reaction after Injection of Glatiramer Acetate (Copaxone®) in Patients with Relapsing-Remitting Multiple Sclerosis

European Neurology — Tue, 22 Nov 2011 23:00:00 +0100

Eur Neurol 2011;66:368–370 (DOI:10.1159/000334107) (Source: European Neurology)

Esomeprazole: Anaphylactic shock (first report) in an elderly patient: case report

Reactions — Tue, 22 Nov 2011 06:51:47 +0100

(Source: Reactions)

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Anaphylaxis to lansoprazole with tolerance to omeprazole.

Allergologia et Immunopathologia — Tue, 22 Nov 2011 05:00:00 +0100

Authors: Aksu K, Kurt E PMID: 22115571 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Anaphylaxis in Latin American children and adolescents: The Online Latin American Survey on Anaphylaxis (OLASA).

Allergologia et Immunopathologia — Mon, 21 Nov 2011 05:00:00 +0100

CONCLUSION: Cutaneous symptoms ranked the order of clinical presentation of SAR. Food was the main triggering agent in the younger cases and insect sting and drugs in the adolescents. Treatment provided for SAR was not appropriate. It is necessary to improve educational programmes in order to enhance the knowledge on this potentially fatal emergency. PMID: 22112535 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Food-Induced Anaphylaxis

Immunology and Allergy Clinics of North America — Mon, 21 Nov 2011 05:00:00 +0100

Food-induced anaphylaxis (FIA) is a serious allergic reaction that may cause death rapidly in otherwise healthy individuals. There is no universal agreement on its definition or criteria for diagnosis. Hospital admissions for FIA have more than doubled in the last decade. Food is one of the most common causes of anaphylaxis, with most surveys indicating that food-induced reactions account for 30% to 50% of cases. The most commonly implicated foods are peanut, tree nuts, milk, eggs, sesame seeds, fish, and shellfish. The only life-saving treatment for anaphylaxis is allergen avoidance, and epinephrine injection if an anaphylactic event occurs. (Source: Immunology and Allergy Clinics of North America)

Patent Blue Dye and An Atypical Anaphylactic Reaction After Sentinel Lymph Node Biopsy in Early Breast Cancer

The Breast Journal — Sun, 20 Nov 2011 05:00:00 +0100

(Source: The Breast Journal)

Therapeutics in Food Allergy: The Current State of the Art

Current Allergy and Asthma Reports — Fri, 18 Nov 2011 17:32:40 +0100

Abstract Food allergy is an increasing public health dilemma in Westernized countries, yet no viable treatments are currently available for those who are afflicted. The only options available for patients with food allergies are prevention of reactions by strict avoidance of the offending food(s) and symptomatic treatment of any adverse effects from accidental exposures. Approaches are being pursued to develop treatments, and allergen-specific therapies such as oral immunotherapy, sublingual immunotherapy, and epicutaneous immunotherapy with different foods have shown promise. Other modalities are also being investigated, potentially leading to the discovery of novel therapeutic options. Content Type Journal ArticleCategory Anaphylaxis and Drug Allergy (P Lieberman and...

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Diffuse cutaneous mastocytosis: analysis of 10 cases and a brief review of the literature

Journal of the European Academy of Dermatology and Venereology — Fri, 18 Nov 2011 05:00:00 +0100

Conclusions Diffuse cutaneous mastocytosis, DCM is a heterogeneous, severe, cutaneous disease, associated with mediator‐related symptoms and risk of anaphylactic shock. Although our results suggest generally favourable prognosis, the review of the literature indicate that SM may occur. Therefore, more guarded prognosis should be given in DCM patients. (Source: Journal of the European Academy of Dermatology and Venereology)

European Medicines Agency confirms positive benefit-risk balance of pholcodine-containing cough medicines

NeLM - News — Fri, 18 Nov 2011 05:00:00 +0100

Source: European Medicines Agency (EMA) Area: News The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has confirmed that the benefits of pholcodine-containing cough medicines outweigh their risks and that these medicines should remain available for the treatment of non-productive (dry) cough in children and adults. Patients taking pholcodine-containing medicines can continue to do so, and should contact their doctor or pharmacist if they have any questions. The review was initiated because of concerns that there could be cross-sensitisation between pholcodine and neuromuscular blocking agents (NMBAs), which in turn could lead to anaphylactic reactions in some patients receiving NMBAs during emergency surgery who had previously taken pholcodine...

A protocol for risk stratification of patients with carboplatin-induced hypersensitivity reactions

Journal of Allergy and Clinical Immunology — Fri, 18 Nov 2011 05:00:00 +0100

Conclusion: Our experience suggests that repeat STs are necessary for risk stratification in patients with a remote clinical history of HSR and an initial negative ST result because there is a significant rate of conversion to a positive ST result. ST converters have an increased risk of HSRs during subsequent carboplatin treatment. (Source: Journal of Allergy and Clinical Immunology)

Onglyza 2.5mg & 5mg film-coated tablets (saxagliptin hydrochloride)- Revised SPC

NeLM - SPC Changes — Thu, 17 Nov 2011 05:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes There have been significant updates to several sections of the SPC, including the following: Change to section 4.3 - Contraindications History of a serious hypersensitivity reaction, including anaphylactic reaction, anaphylactic shock, and angioedema, to any dipeptidyl peptidase 4 (DPP4) inhibitor (see sections 4.4 and 4.8). Change to section 4.4 - Special warnings and precautions for Use The following adverse reactions have been reported with the use of saxagliptin: serious hypersensitivity reactions, including anaphylactic reaction, anaphylactic shock, and angioedema. If a serious hypersensitivity reaction to saxagliptin ...

Vaccines and Immunomodulatory Therapies for Food Allergy

Current Allergy and Asthma Reports — Wed, 16 Nov 2011 16:47:16 +0100

Abstract The apparent increase in food allergy prevalence has led to a surge in the amount of clinical and basic science research dedicated to the field. At the current time, allergen avoidance remains the cornerstone of treatment; however, recent clinical trials investigating various forms of immunotherapy have opened doors to the possible future application of an active treatment strategy in everyday practice. In addition, improvements in molecular biology have allowed researchers to purify, clone, and modify allergens, thus laying the groundwork for research on vaccines using modified proteins of decreased allergenicity. Finally, various allergen-nonspecific immunomodulatory therapies are also being investigated as a means to alter the immune response to food allergens....

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Mediators Released During Human Anaphylaxis

Current Allergy and Asthma Reports — Tue, 15 Nov 2011 16:48:11 +0100

Abstract A range of mediators are generated during anaphylaxis, with redundancy of effects, multiple overlapping pathways, and involvement of several cell types. Key steps in the reaction occur at the site of initial contact, and mediators may not be detectable systemically. Furthermore, the potencies of various mediators vary enormously, and clinical effects may occur below our level of detection. We also do not know what converts (amplifies) a local reaction into systemic anaphylaxis. Murine models have identified several novel mediators that may propagate and/or regulate this process and also indicate that circulating neutrophils may play an important role in reaction amplification. Differential expression of various genes within specific intracellular signalling pathwa...

Treatment of Insect Sting Anaphylaxis Woefully InadequateTreatment of Insect Sting Anaphylaxis Woefully Inadequate

Medscape Medical News Headlines — Tue, 15 Nov 2011 16:24:40 +0100

Patients with anaphylactic reactions to insect stings are being poorly managed when they present to the emergency department; guidelines are not being followed. Medscape Medical News (Source: Medscape Medical News Headlines)

Olanzapine-Induced Anaphylactic Shock: A Case Report

Pharmacopsychiatry — Tue, 15 Nov 2011 05:00:00 +0100

We report a case of a 33-year-old psychiatric patient, with bipolar affective disorder, who developed anaphylaxis as a late reaction to olanzapine. This case report shows the possibility, although rare, of a severe late anaphylactic reaction to olanzapine.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)

Anaphylaxis: recognition and management.

American Family Physician — Tue, 15 Nov 2011 05:00:00 +0100

Authors: Arnold JJ, Williams PM Abstract Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms. Dermatologic and respiratory symptoms are most common, occurring in 90 and 70 percent of episodes, respectively. The three most common triggers are food, insect stings, and medications. The diagnosis of anaphylaxis is typically made when symptoms occur within one hour of exposure to a specific antigen. Confirmatory testing using...

Histopathologic Observations After Intra-arterial Chemotherapy for Retinoblastoma [Clinical Sciences]

Archives of Opthalmology — Mon, 14 Nov 2011 05:00:00 +0100

Conclusion Retinoblastoma can be controlled with IAC, but histopathology of enucleated eyes reveals that ocular complications including thromboembolic events can occur. (Source: Archives of Opthalmology)

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Tropomyosin sensitization in house dust mite allergic patients

European Archives of Oto-Rhino-Laryngology — Fri, 11 Nov 2011 12:46:35 +0100

In conclusion, cross-reactivity to tropomyosin in house dust mite allergic patients in southern Bavaria, Germany is rarer than suspected. Beside the direct allergic reactions, a further part of reactions to seafood must therefore be ascribed to other mechanisms such as intoxication or intolerance to, e.g. additives in the food product. Content Type Journal ArticleCategory MiscellaneousPages 1-6DOI 10.1007/s00405-011-1826-1Authors Sven Becker, Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig Maximilian University, Marchioninistrasse 15, 81377 Munich, GermanyMoritz Gröger, Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig Maximilian University, Marchioninistrasse 15, 81377 Munich, GermanyMartin Canis, Department of Otorhinolaryngology-Head and Neck Sur...

The Anisakis allergy debate: does an evolutionary approach help?

Trends in Parasitology — Fri, 11 Nov 2011 05:00:00 +0100

Authors: Daschner A, Cuéllar C, Rodero M Abstract Allergic phenomena share common pathways with the immune response against helminth parasites. The definitions regarding allergens and their related concepts have their roots in the area of allergy research. The experience with the fish parasite Anisakis simplex-associated allergic features still nurtures an open debate on the necessity of larvae being alive to induce allergic reactions such as urticaria or anaphylaxis. Conceptual definitions of allergen, major allergen, as well as putatively crossreacting antibodies, as are used in food allergy, depend on the clinical relevance of specific IgE and deserve careful interpretation in the various forms of A. simplex-associated allergic features. Conversely, an evolutionary based interp...

Personal and parental nativity as risk factors for food sensitization

Journal of Allergy and Clinical Immunology — Fri, 11 Nov 2011 05:00:00 +0100

Conclusion: Although foreign-born children and adolescents are at lower risk of food sensitization compared with those born in the US, among those born in the US, the children of immigrants are at the highest risk. (Source: Journal of Allergy and Clinical Immunology)

Levobupivacaine: Anaphylaxis: case report

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

(Source: Reactions)

Severe ranitidine‐induced anaphylaxis: a case report and literature review

Journal of Clinical Pharmacy and Therapeutics — Thu, 10 Nov 2011 07:46:35 +0100

Conclusion: We re‐emphasize a potentially serious, albeit very rare, adverse effect of ranitidine and summarize other reported cases. This case demonstrates that commonly used, generally safe drugs may on occasions cause serious adverse effects. (Source: Journal of Clinical Pharmacy and Therapeutics)

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Limited Influence of Aspirin Intake on Mast Cell Activation in Patients with Food-dependent Exercise-induced Anaphylaxis: Comparison Using Skin Prick and Histamine Release Tests.

Acta Dermato-Venereologica — Wed, 09 Nov 2011 05:00:00 +0100

Authors: Fukunaga A, Shimizu H, Tanaka M, Kikuzawa A, Tsujimoto M, Sekimukai A, Yamashita J, Horikawa T, Nishigori C Abstract Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe systemic syndrome induced by physical exercise after ingesting causative food. Aspirin is a well-known trigger for anaphylaxis in patients with FDEIA. Possible mechanisms by which symptoms are aggravated by aspirin include enhanced antigen absorption and mast cell activation. The aim of this study was to determine whether aspirin intake has an influence on mast cell/basophil activation in patients with FDEIA. Provocation tests revealed that adding aspirin to the causative food challenge in 7 of 9 (77.8%) patients with FDEIA provoked symptoms. In most cases, pretreatment with aspirin did not enha...

Cosmetic facial peel-induced contact anaphylaxis: chestnut allergy without latex-fruit syndrome.

Journal of Investigational Allergology and Clinical Immunology — Mon, 07 Nov 2011 15:00:03 +0100

Authors: Seitz CS, Trautmann A PMID: 21995188 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)

Reducing the risk of anaphylaxis during anesthesia: 2011 updated guidelines for clinical practice.

Journal of Investigational Allergology and Clinical Immunology — Mon, 07 Nov 2011 15:00:03 +0100

Authors: Mertes PM, Malinovsky JM, Jouffroy L, , Aberer W, Terreehorst I, Brockow K, Demoly P, , Abstract These guidelines represent the updated consensus of experts in the field of immediate hypersensitivity reactions occurring during anesthesia. They provide a series of valid, widely accepted, effective, and easily teachable guidelines that are the fruit of current knowledge, research, and experience. The guidelines are based on the findings of international scientific research and have been implemented in France under the auspices of the French Society for Anaesthesia and Intensive Care (Société Française d'Anesthésie et de Réanimation [SFAR]) and the French Society of Allergology (Société Française d'Allergologie [SFA]). The members of the European Network for Drug All...

Asthma Control And Anaphylaxis Guidelines: Improving Outcomes For Adults With Allergies And Asthma

Health News from Medical News Today — Mon, 07 Nov 2011 09:00:00 +0100

Cholesterol-lowering Drugs May Worsen Asthma Cholesterol-lowering medications may help millions fight heart disease, but this class of drugs may worsen asthma control, according to a study presented at the American College of Allergy, Asthma and Immunology Annual Meeting in Boston, Nov. 3-8. In the preliminary study researchers compared 20 patients with asthma taking prescribed cholesterol-lowering medication or statins, to 20 patients with asthma who did not take the drugs... (Source: Health News from Medical News Today)

ACAAI Annual Meeting abstracts: Improved outcomes for adults with allergies and asthma

EurekAlert! - Social and Behavioral Science — Sat, 05 Nov 2011 04:00:00 +0100

(American College of Allergy, Asthma, and Immunology) The abstracts are; Cholesterol-lowering drugs may worsen asthma; Depression and emotional well-being affect seniors' asthma related control and quality of life; Treatment guidelines not followed after food-induced anaphylaxis; Stung by poor management of insect-sting reactions. (Source: EurekAlert! - Social and Behavioral Science)

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Structural and Immunologic Characterization of Ara h 1 [Lipids]

Journal of Biological Chemistry — Fri, 04 Nov 2011 04:00:00 +0100

Allergic reactions to peanuts and tree nuts are major causes of anaphylaxis in the United States. We compare different properties of natural and recombinant versions of Ara h 1, a major peanut allergen, through structural, immunologic, and bioinformatics analyses. Small angle x-ray scattering studies show that natural Ara h 1 forms higher molecular weight aggregates in solution. In contrast, the full-length recombinant protein is partially unfolded and exists as a monomer. The crystal structure of the Ara h 1 core (residues 170–586) shows that the central part of the allergen has a bicupin fold, which is in agreement with our bioinformatics analysis. In its crystalline state, the core region of Ara h 1 forms trimeric assemblies, while in solution the protein exists as higher molecular we...

End point prick test: could this new test be used to predict the outcome of oral food challenge in children with cow's milk allergy?

Italian Journal of Pediatrics — Fri, 04 Nov 2011 04:00:00 +0100

Conclusions: EPT is a safe and cheap test, easy to be executed and that could provide good prediction of the outcome of OFC; so it might be used to avoid OFC-induced anaphylaxis in children affected by CMA. It can also help avoiding dietetic restrictions in tolerant children who show sensitization towards cow's milk proteins. (Source: Italian Journal of Pediatrics)

Anaphylaxis with Latrodectus Antivenin Resulting in Cardiac Arrest.

Journal of Medical Toxicology — Fri, 04 Nov 2011 04:00:00 +0100

We report a case of a 37-year-old male with a history of asthma that was given L. mactans antivenin for symptoms related to a black widow envenomation and developed a severe anaphylactic reaction resulting in cardiac arrest. When traditional therapies failed, the patient was given methylene blue for anaphylactic shock resulting in a 30-h period of hemodynamic stability. Despite initial resuscitation, the patient ultimately died 40 h after presentation. Under the right circumstances, L. mactans antivenin remains a safe and effective therapy for severe black widow envenomations. However, anaphylaxis is a risk for those receiving this therapy, even when the antivenin is diluted and given as an infusion. We report the first death related to diluted L. mactans antivenin given as an infusion. ...

In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties.

Food and Chemical Toxicology — Fri, 04 Nov 2011 04:00:00 +0100

Authors: Han T, Cheng G, Liu Y, Yang H, Hu YT, Huang W Abstract Tectoridin (4',5,7-thrihydroxy-6-methoxyisoflavone-7-O-β-d-glucopyranoside) isolated from the flowers of Pueraria thunbergiana is reported to have less hepatoprotective, hypoglycemic, antiallergic and anaphylaxis inhibitory activity than its aglycone form tectorigenin. To obtain tectorigenin, tectoridin was hydrolyzed in the current study. However, practical limitations of tectorigenin do exist due to its poor water-solubility. To increase its water-solubility, tectorigenin was sulfonated with sulfuric acid (98wt.%) and mixed with saturated salt water to produce tectorigenin sodium sulfonate. Tectoridin and the two transfer products were identified by UV, IR, HPLC-MS, (1)H NMR and (13)C NMR, and the solubility of tect...

Methylene blue administration in the compound 48/80-induced anaphylactic shock: hemodynamic study in pigs.

Acta Cirurgica Brasileira — Fri, 04 Nov 2011 01:46:44 +0100

CONCLUSION: Despite our data, the clinical manifestations improvement brings some optimism and does not allow excluding the MB as a possible therapeutic option in the anaphylactic shock. PMID: 22042112 [PubMed - in process] (Source: Acta Cirurgica Brasileira)

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Life‐threatening anaphylaxis to leuprorelin acetate depot: Case report and review of the literature

International Journal of Urology — Thu, 03 Nov 2011 04:00:00 +0100

We present the first case report of a Japanese man who developed anaphylaxis to leuprorelin acetate depot during the treatment of metastatic prostate cancer and recovered successfully by conservative treatment. A drug‐lymphocyte stimulation test showed that not only leuprorelin acetate itself, but also its vehicle polylactic and glycolic acids, might be responsible for the anaphylaxis to leuprorelin acetate depot. Because anaphylaxis can be lethal, the present case suggests that one should bear in mind the possibility of anaphylaxis in all patients who receive gonadotropin‐releasing hormone analog depot and monitor such patients carefully. (Source: International Journal of Urology)

Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model

Allergy — Thu, 03 Nov 2011 04:00:00 +0100

Conclusion: We concluded that oral tolerance for food antigens is induced in two ways: (i) by initial exposure to antigen, or inherent tolerance, and (ii) by transfer of Tregs, or acquired tolerance. Because food allergies occur when inherent tolerance is absent, understanding of acquired tolerance is important for the development of therapies for food allergy. (Source: Allergy)

A Contemporary Review of Seafood Allergy

Clinical Reviews in Allergy and Immunology — Wed, 02 Nov 2011 05:49:57 +0100

Abstract Seafood is common item in the world diet; Asian countries have the highest rates of fish consumption in the world, which is higher than world average. Several studies have been conducted on the epidemiology and clinical characteristics of seafood allergy in different countries, and some of the fish and seafood allergens unique to those regions have been characterized. Review on published data showed that seafood allergy is very ubiquitous in some regions of the world. Fish and shellfish are the most common seafood that cause adverse allergic reactions among nations; the symptoms ranged from oral allergy syndromes to urticaria and anaphylaxis. The major identified allergens are parvalbumin in fish and tropomyosin in shellfish. Nevertheless, such studies are lacking...

High effectiveness of pandemic influenza A (H1N1) vaccination in healthcare workers from a Portuguese hospital

International Archives of Occupational and Environmental Health — Tue, 01 Nov 2011 16:52:19 +0100

Conclusion Vaccination reduced the pH1N1 infection risk considerably. The pandemic plan to contain the pH1N1 infection was successful. Nurses had the highest risk of pH1N1 infection and are therefore a target group for vaccination measures. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00420-011-0714-8Authors José Torres Costa, Occupational Health Division, S. João Hospital, EPE, Porto, PortugalRui Silva, Occupational Health Division, S. João Hospital, EPE, Porto, PortugalMargarida Tavares, Medical School, Oporto University, Porto, PortugalAlbert Nienhaus, University Medical Centre Hamburg-Eppendorf, Institute for Health Service Research in Dermatology and Nursing, Martinistraße 52, 20246 Hamburg, Germany Journal International ...