MedWorm: Anaphylactic Shock

Wheat-dependent exercise-induced anaphylaxis exclusively during menstruation

Allergy — Sun, 21 Mar 2010 00:00:00 +0100

(Source: Allergy)

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Glucocorticoids for the treatment of anaphylaxis.

Cochrane Database of Systematic Reviews — Sat, 20 Mar 2010 06:22:03 +0100

CONCLUSIONS: We are, based on this review, unable to make any recommendations for the use of glucocorticoids in the treatment of anaphylaxis. PMID: 20238355 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Safety of a 2-visit cluster schedule of venom immunotherapy in outpatients at risk of life-threatening anaphylaxis.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

Authors: Sánchez-Machín I, Moreno C, González R, Iglesias-Souto J, Pérez E, Matheu V PMID: 20232782 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Edema of the uvula: etiology, risk factors, diagnosis, and treatment.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

Authors: Alcoceba E, Gonzalez M, Gaig P, Figuerola E, Auguet T, Olona M Edema of the uvula (EU) is a rare occurrence sometimes associated with angioedema, urticaria, and anaphylaxis. We analyze the causes, predisposing factors, and characteristics of EU in a group of 58 patients with a mean (SD) age of 48.2 (15.2) years over the course of a year. Of the 58 patients studied, 49 (84.5%) were male and 44 (75.9%) presented isolated EU. Thirty-two patients (55.1%) with no clear etiology were classed as idiopathic. Snoring and a high body mass index were more prevalent in these patients. A variety of probable causes were identified in 26 patients (44.9%). In this group, EU was usually accompanied by urticaria, angioedema, and anaphylaxis and there was also a greater prevalence of atopy. We f...

Recurrent anaphylaxis due to lupin flour: primary sensitization through inhalation.

Journal of Investigational Allergology & Clinical Immunology — Fri, 19 Mar 2010 22:20:04 +0100

We present a case of recurrent anaphylaxis due to lupin flour as a hidden food allergen with primary sensitization due to exposure to ground lupin via inhalation. We found cross-reactivity between lupin and vetchling but not other legumes. PMID: 20232777 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

Anaphylaxis of small arteries: putative role of nitric oxide and prostanoids.

Medicina (Kaunas) — Thu, 18 Mar 2010 21:02:03 +0100

CONCLUSIONS. Despite anaphylactic contraction, nitric oxide seems to be released from the endothelium following antigen challenge in the small coronary and mesenteric arteries. This may contribute to the development of hypotension during anaphylaxis. Prostanoids are playing a different role - the contracting products of cyclooxygenase pathway are important for the development of anaphylactic contraction of the small isolated arteries. PMID: 20234162 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))

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Severe vancomycin-induced anaphylactic reaction.

Medicina (Kaunas) — Thu, 18 Mar 2010 21:02:03 +0100

We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection. PMID: 20234160 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))

Immediate Hypersensitivity to Moxifloxacin with Tolerance to Ciprofloxacin: Report of Three Cases and Review of the Literature (April).

The Annals of Pharmacotherapy — Tue, 16 Mar 2010 00:00:00 +0100

CONCLUSIONS: Based on our experience, patients who develop immediate hypersensitivity reactions to moxifloxacin may receive ciprofloxacin therapy in an appropriately monitored setting if they have previously tolerated full treatment courses of ciprofloxacin. Research into whether there is a specific side chain reaction unique to moxifloxacin is warranted. PMID: 20233910 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

The Journal of Experimental Medicine — Mon, 15 Mar 2010 17:12:56 +0100

Systemic exacerbation of allergic responses, in which mast cells play a critical role, results in life-threatening anaphylactic shock. Sphingosine-1–phosphate (S1P), a ligand for a family of G protein–coupled receptors, is a new addition to the repertoire of bioactive lipids secreted by activated mast cells. Yet little is known of its role in human mast cell functions and in anaphylaxis. We show that S1P2 receptors play a critical role in regulating human mast cell functions, including degranulation and cytokine and chemokine release. Immunoglobulin E–triggered anaphylactic responses, including elevation of circulating histamine and associated pulmonary edema in mice, were significantly attenuated by the S1P2 antagonist JTE-013 and in S1P2-deficient mice, in contrast to a...

Bee stings as therapy? Apitherapy can treat arthritis and more

NaturalNews.com — Sun, 14 Mar 2010 07:00:00 +0100

(NaturalNews) A bee sting is an unpleasant experience that undoubtedly everyone would choose to avoid if given the choice. However a growing number of people are choosing to be stung by bees in an alternative form of illness treatment called apitherapy. Apitherapy contends that bee venom holds therapeutic value in treating serious illness and that it is a viable alternative to dangerous pharmaceutical drugs that often do not work and have harmful side effects.Apitherapy, a traditional folk remedy that has been used in many other countries for centuries, takes advantage of the healing power contained in honeybee venom which helps to alleviate serious conditions like multiple sclerosis, arthritis, and lupus. According to 51-year-old Reyah Carlson of Vermont, a proponent of apitherapy, bee ve...

[Patent blue V : Inert dye or potent allergen?]

Der Anaesthesist — Sat, 13 Mar 2010 00:00:00 +0100

Authors: Rogler V, Röhm C, Reutershan J Patent blue V is widely used as a food dye. Clinically, patent blue V dye has been increasingly used in oncological surgery to identify the sentinel lymph nodes in breast cancer and other malignancies. The case of a patient who developed severe anaphylactic shock to subcutaneous injection of patent blue V during breast surgery is presented. The clinical course and the anesthesiological management are presented, and the pitfalls that may delay the correct diagnosis are highlighted. PMID: 20224949 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)

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[Anaphylaxis during anaesthesia.]

Tidsskrift for den Norske Laegeforening — Thu, 11 Mar 2010 00:00:00 +0100

Authors: Guttormsen AB, Harboe T, Pater G, Florvaag E Background. Anaphylaxis is a serious life-threatening generalized or systemic hypersensitivity reaction. The aim of this paper is to provide knowledge on how to diagnose, treat and follow up patients with suspected anaphylaxis during general and local anaesthesia. Material and methods. The article is based on literature identified through a non-systematic search in PubMed, the Scandinavian Guidelines on anaphylaxis during anaesthesia and on own research. Results. Anaphylactic symptoms during anaesthesia vary with respect to severity. Manifestations from skin and the cardiovascular and respiratory systems are present simultaneously in approximately 70 % of patients. Early treatment with adrenaline, fluid and extra oxygen may be vital...

[Risk in anaesthesia.]

Tidsskrift for den Norske Laegeforening — Thu, 11 Mar 2010 00:00:00 +0100

This article focuses on frequency, causes, and prevention of the most important anaesthetic complications. Material and methods. The article is based on literature identified through a non-systematic search in Pub-Med, and the author's research and experience in this field. Results. The risk of death associated with anaesthesia is closely related to patient age and physical status. In otherwise healthy patients (ASA 1), the risk of such deaths is approximately 1:250 000. Medication errors occur in approximately 1:1 000 anaesthetic procedures. The risk of awareness during general anaesthesia is approximately 1:650. Neural injury from epidural and spinal anaesthesia is rare, even more so in obstetrics. Anaphylaxis caused by muscle relaxant drugs is more common in Norway than in many other in...

Suppression of allergen-induced respiratory dysfunction and airway inflammation in sensitized guinea pigs by Mn(II)(Me(2)DO2A), a novel superoxide scavenger compound.

Free Radical Biology and Medicine — Thu, 11 Mar 2010 00:00:00 +0100

In conclusion, our findings support the potential therapeutic use of Mn(II)(Me(2)DO2A) as novel superoxide scavenger drug in asthma and anaphylactic reactions. PMID: 20227487 [PubMed - as supplied by publisher] (Source: Free Radical Biology and Medicine)

Which Symptoms Are Red Flags for Anaphylaxis?

Medscape Today Headlines — Wed, 10 Mar 2010 15:43:46 +0100

Anaphylaxis is a medical emergency that must be recognized and managed promptly. Look for the dramatic onset of symptoms. USMLEasy from McGraw-Hill (Source: Medscape Today Headlines)

Oral mite anaphylaxis

Allergy — Wed, 10 Mar 2010 00:00:00 +0100

(Source: Allergy)

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Anaphylaxis after consuming soy products in patients with birch pollinosis

Allergy — Sat, 06 Mar 2010 00:00:00 +0100

(Source: Allergy)

Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization

Clinical and Experimental Allergy — Thu, 04 Mar 2010 00:00:00 +0100

Elevation of the gastric pH increases the risk for sensitization against food allergens by hindering protein breakdown. This can be caused by acid-suppressing medication like sucralphate, H2-receptor blockers and proton pump inhibitors, as shown in recent murine experimental and human observational studies. The aim of the present study was to assess the sensitization capacity of the dietary supplement base powder and of over-the-counter antacids. Changes of the pH as well as of protein digestion due to base powder or antacids were measured in vitro. To examine the in vivo influence, BALB/c mice were fed codfish extract with one of the acid-suppressing substances. Read-out of antibody levels in the sera, of cytokine levels of stimulated splenocytes and of intradermal skin tests was performe...

Carbohydrate in Red Meat Tied to Delayed Anaphylaxis

Medscape Allergy Headlines — Tue, 02 Mar 2010 16:58:40 +0100

A carbohydrate in red meat called alpha-gal is an important under-recognized cause of delayed idiopathic anaphylactic reactions, according to research presented Sunday at the American Academy of Allergy, Asthma & Immunology annual meeting underway in New Orleans. Reuters Health Information (Source: Medscape Allergy Headlines)

AAAAI: Anaphylaxis to Meat Is Medium Rare (CME/CE, with video)

MedPage Today Allergy — Mon, 01 Mar 2010 20:31:05 +0100

NEW ORLEANS (MedPage Today) -- An allergy to meat may be responsible for up to half of recurrent anaphylaxis cases without known cause, researchers said. (Source: MedPage Today Allergy)

Cephalosporins Safe for Patients With Negative Skin Tests

Medscape Today Headlines — Mon, 01 Mar 2010 17:07:59 +0100

Patients with a history of penicillin anaphylaxis but with negative penicillin skin tests can safely take cephalosporins, new research shows. Medscape Medical News (Source: Medscape Today Headlines)

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Rocuronium bromide: Anaphylaxis: case report

Reactions — Mon, 01 Mar 2010 14:50:10 +0100

(Source: Reactions)

The natural history of soy allergy

Journal of Allergy and Clinical Immunology — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions: In this referral population approximately 50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy. (Source: Journal of Allergy and Clinical Immunology)

Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy

Journal of Allergy and Clinical Immunology — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions: Greater IgE epitope diversity and higher affinity, as determined by using the peptide microarray, were associated with clinical phenotypes and severity of milk allergy. (Source: Journal of Allergy and Clinical Immunology)

Meat Might Be Behind Many Unidentified Allergic Reactions

MedlinePlus Health News — Sun, 28 Feb 2010 14:00:00 +0100

Certain carb could be causing severe anaphylaxis, researchers warn Source: HealthDay Related MedlinePlus Pages: Allergy, Carbohydrates, Dietary Proteins (Source: MedlinePlus Health News)

Is Anaphylaxis Triggered By Eating Meat More Common Than We Think?

Health News from Medical News Today — Sun, 28 Feb 2010 08:00:00 +0100

According to research presented at the 2010 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI), a carbohydrate in meat called alpha-gal is an under recognized culprit in patients with recurring anaphylaxis. An individual who has had an anaphylactic reaction to something unknown is at an increased risk for repeated episodes if the trigger for the reaction is not identified... (Source: Health News from Medical News Today)

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Is Anaphylaxis Triggered By Eating Meat More Common Than We Think?

Allergy News From Medical News Today — Sun, 28 Feb 2010 08:00:00 +0100

Severe allergic reaction to meat may not be rare

Reuters: Health — Sun, 28 Feb 2010 05:01:33 +0100

WASHINGTON (Reuters) - Eating meat may be a much more common trigger for anaphylaxis -- a severe and potentially deadly allergic reaction -- than previously thought, U.S. researchers said on Sunday. (Source: Reuters: Health)

Most Patients With A History Of Anaphylaxis To Penicillin Can Take Cephalosporins

Health News from Medical News Today — Sat, 27 Feb 2010 08:00:00 +0100

According to new research presented at the 2010 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI), most patients who reported a history of anaphylaxis to penicillin can safely take cephalosporins. Cephalosporins, which are the most frequently prescribed class of antibiotics, are related to penicillin in their structure, uses and effects. "Almost all patients undergoing major surgery receive antibiotics to reduce the risk of infections... (Source: Health News from Medical News Today)

Most Patients With A History Of Anaphylaxis To Penicillin Can Take Cephalosporins

Allergy News From Medical News Today — Sat, 27 Feb 2010 08:00:00 +0100

Histamine induces Th2 activation through the histamine receptor 1 in house dust mite rhinitic but not asthmatic patients

Clinical and Experimental Allergy — Fri, 26 Feb 2010 00:00:00 +0100

Effects of mast cell-released histamine on smooth muscle and endothelial cells are considered as responsible of immediate symptoms of anaphylaxis. However, little is known about histamine effects on Th2 lymphocytes, which orchestrate the allergic reaction upstream of mast cells. We addressed this question in house dust mite (HDM) allergics, according to the presence of rhinitis or asthma and allergen stimulation. Peripheral blood mononuclear cell from 15 rhinitic and 14 asthmatic HDM-allergic subjects and 16 controls were cultured with Der p 1 or histamine. The effect of Der p 1 on histamine receptor (H1R and H2R) expression was studied. T-cell cytokine production was studied upon Der p 1 or histamine stimulation. The role of H1R in histamine effects was assessed with levocetirizine. H1R a...

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Adverse drug reactions linked to Ciwujia injection: a systematic review of 521 cases

Journal of Evidence-Based Medicine — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion The relevant information of ADRs for Ciwujia injection was insufficiently reported in included studies. The ADR type distribution between clinical studies and ADR reports was inconsistency. Most of the reported ADRs were mild, and were treated successfully by slowing down the drip velocity or by withdrawing the drug and treating the symptoms. As Ciwujia injection was one of the highest numbers of ADR reports of traditional Chinese medicine injections, high quality ADR monitoring, standardized ADR reporting, and timely analysis risk factors of ADRs are extremely urgent. (Source: Journal of Evidence-Based Medicine)

Avoiding adverse drug reactions to Chinese medicine injections

Journal of Evidence-Based Medicine — Thu, 25 Feb 2010 00:00:00 +0100

A total of 109 varieties of Chinese medicine injections (CMI) have been approved by the State Food and Drug Administration of China, all of which have the potential to induce adverse drug reactions (ADRs). Major ADRs include systemic anaphylaxis, anaphylactic shock, acute intravascular hemolysis, hepatorenal damage, skin lesion, cardiac damage, respiratory system injury, and gastrointestinal disorders. Contributing factors of ADRs include healthcare workers' inadequate attention to ADRs of CMI, complex ingredients, allergic uncertainties, and inappropriate drug use in children and the aged. To decrease ADRs resulting from CMI, it is essential to improve the selection of drug indications, delivery of proper dosage regimens, compliance with drug instructions, and selection of solvents for th...

Coronary Artery Bypass Grafting in Cold-Induced Urticaria [CASE REPORTS]

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 22:46:26 +0100

We report the case of a 41-year-old woman with chronic cold-induced urticaria, who underwent a successful coronary bypass grafting, and describe perioperative management of this rare disorder. (Source: The Annals of Thoracic Surgery)

Coronary Artery Bypass Grafting in Cold-Induced Urticaria.

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 13:09:39 +0100

Antithymocyte globulin: Anaphylaxis: case report

Reactions — Mon, 22 Feb 2010 14:16:47 +0100

(Source: Reactions)

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Imiglucerase: Anaphylaxis, with subsequent desensitisation, in a child: case report

Reactions — Mon, 22 Feb 2010 14:16:47 +0100

(Source: Reactions)

Picibanil: Anaphylaxis: case report

Reactions — Mon, 22 Feb 2010 14:16:47 +0100

(Source: Reactions)

Repeated anaphylactic responses induced by oral challenge with ranitidine.

Acta Derm Venereol A... — Sun, 21 Feb 2010 21:20:59 +0100

Authors: Walker AI, Werfel S, Kick G, Przybilla B PMID: 20169307 [PubMed - in process] (Source: Acta Derm Venereol A...)

Doctors confident of 'cure' for childhood peanut allergy

Guardian Unlimited Science — Sun, 21 Feb 2010 14:37:55 +0100

Researchers in Cambridge to launch three-year £1m trial to desensitise sufferers of allergy that affects 4% of schoolchildrenDoctors are launching a major clinical trial in the search for a long-term treatment for peanut allergy after children suffering from the condition were treated successfully for the first time.Researchers at Addenbrookes hospital in Cambridge will begin the £1m government-funded immunotherapy trial next month after a pilot study showed children who had a severe reaction to peanuts could be desensitised.The therapy is the most promising development yet in doctors' search for a long-term treatment for the allergy, which affects 4% of British schoolchildren.Children who suffer a reaction to peanuts can experience a constriction of the airways, breathing trouble, asthm...

Major trial of peanut allergy treatment

Guardian Unlimited Science — Sun, 21 Feb 2010 14:37:55 +0100

Researchers in Cambridge to launch three-year £1m trial to desensitise sufferers of allergy that affects 4% of schoolchildrenDoctors are launching a major clinical trial in the search for a long-term treatment for peanut allergy after children suffering from the condition were treated successfully for the first time.Researchers at Addenbrookes hospital in Cambridge will begin the £1m government-funded immunotherapy trial next month after a pilot study showed children who had a severe reaction to peanuts could be desensitised.The therapy is the most promising development yet in the search for a long-term treatment for the allergy, which affects 4% of British schoolchildren.Children who suffer a reaction to peanuts can experience a constriction of the airways, breathing trouble, asthma, it...

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Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia

Blood — Thu, 18 Feb 2010 17:01:20 +0100

Over the past several decades, L-asparaginase, an important component of therapy for acute lymphoblastic leukemia (ALL), has typically been administered intramuscularly rather than intravenously in North America because of concerns regarding anaphylaxis. We evaluated the feasibility of giving polyethylene glycosylated (PEG)–asparaginase, the polyethylene glycol conjugate of Escherichia coli L-asparaginase, by intravenous infusion in children with ALL. Between 2005 and 2007, 197 patients (age, 1-17 years) were enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 05-01 and received a single dose of intravenous PEG-asparaginase (2500 IU/m2) over 1 hour during remission induction. Serum asparaginase activity more than 0.1 IU/mL was detected in 95%, 88%, and 7% of patients at ...

Action on anaphylaxis action plans

Journal of Paediatrics and Child Health — Tue, 16 Feb 2010 00:00:00 +0100

The provision of a written anaphylaxis action plan is considered to be an essential component of the management of food-allergic children prescribed self-injectable adrenaline. Literature review indicates that the evidence that such plans are of benefit is incomplete; however, commonsense would suggest that this is the case. Controlled trials are unlikely to be performed. The Australasian Society of Clinical Immunology and Allergy has recently released three anaphylaxis action plans that meet the differing needs of those children prescribed self-injectable adrenaline, those who do not warrant self-injectable adrenaline provision and those with insect allergy. (Source: Journal of Paediatrics and Child Health)

Ceftriaxone: Fatal anaphylactic shock during intradermal skin testing: case report

Reactions — Mon, 15 Feb 2010 14:06:03 +0100

(Source: Reactions)

Gadobenate dimeglumine/gadoteridol: Anaphylaxis in elderly patients: 2 case reports

Reactions — Mon, 15 Feb 2010 14:06:03 +0100

(Source: Reactions)

The Platelet Activating Factor (PAF) Signaling Cascade in Systemic Inflammatory Responses.

Biochimie — Mon, 15 Feb 2010 00:00:00 +0100

Authors: Yost CC, Weyrich AS, Zimmerman GA The platelet activating factor (PAF) signaling cascade evolved as a component of the repertoire of innate host defenses, but is also an effector pathway in inflammatory and thrombotic diseases. This review focuses on the PAF signaling cascade in systemic inflammatory responses and, specifically, explores its activities in experimental and clinical sepsis and anaphylaxis in the context of the basic biochemistry and biology of signaling via this lipid mediator system. PMID: 20167241 [PubMed - as supplied by publisher] (Source: Biochimie)

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Anaphylaxis

Karger Publishers — Sun, 14 Feb 2010 13:56:26 +0100

ISBN: 978-3-8055-9441-7 (Source: Karger Publishers)

[Allergic risk during paediatric anaesthesia.]

Annales Francaises d'Anesthesie et de Reanimation — Fri, 12 Feb 2010 00:00:00 +0100

CONCLUSIONS: Allergic reactions to NMBAs occurring during paediatric anaesthesia are rare whereas those with latex are more frequent. Therefore, the reduction of the allergic risk during paediatric anaesthesia essentially requires a latex-free environment. PMID: 20153947 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)

Anaphylaxis to mefenamic acid in a patient with new onset of systemic lupus erythematosus.

Allergologia et Immunopathologia — Thu, 11 Feb 2010 00:00:00 +0100

Authors: Couto M, Duarte C, Geraldes L, Inês L, Malcata A PMID: 20153574 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

Cefuroxime axetil: Anaphylaxis with Kounis syndrome: case report

Reactions — Wed, 10 Feb 2010 14:08:42 +0100

(Source: Reactions)

Gadoteridol: Anaphylaxis: case report

Reactions — Wed, 10 Feb 2010 14:08:42 +0100

(Source: Reactions)

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Iomeprol/ioversol: Recurrent anaphylaxis: case report

Reactions — Wed, 10 Feb 2010 14:08:42 +0100

(Source: Reactions)

Usefulness of the basophil activation test (BAT) in the diagnosis of life-threatening drug anaphylaxis

Allergy — Wed, 10 Feb 2010 00:00:00 +0100

(Source: Allergy)

Anaphylaxis to Raphanus niger

Allergy — Wed, 10 Feb 2010 00:00:00 +0100

(Source: Allergy)

Toothpaste-induced anaphylaxis caused by mint (Mentha) allergy

Allergy — Wed, 10 Feb 2010 00:00:00 +0100

(Source: Allergy)

Recognition and treatment of anaphylaxis

Nursing in Critical Care — Tue, 09 Feb 2010 00:00:00 +0100

The aim of this paper is to discuss the recognition, treatment and investigation of anaphylaxis. Anaphylaxis is a severe, life-threatening, generalized or systemic hypersensitivity reaction. It is characterized by rapidly developing life-threatening airway and/or breathing and/or circulation problems usually associated with skin and/or mucosal changes. The incidence of anaphylaxis appears to be increasing. A wide range of triggers can cause anaphylaxis. Drugs are the commonest cause of anaphylaxis in hospital and foods in the out-of-hospital setting. Patients having anaphylaxis should be treated using the airway, breathing, circulation, disability, exposure (ABCDE) approach. Early treatment with intramuscular adrenaline is the treatment of choice for patients having anaphylaxis. Intravenou...

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Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System

Journal of Allergy and Clinical Immunology — Mon, 08 Feb 2010 00:00:00 +0100

Subcutaneous allergen immunotherapy (SCIT) is an effective treatment for allergic rhinitis, asthma and venom hypersensitivity and has the potential of producing serious life-threatening anaphylaxis. Adverse reactions are generally classified into 2 categories: local reactions, which can manifest as redness, pruritus, and swelling at the injection site, and systemic reactions (SRs). SRs can range in severity from mild rhinitis to fatal cardiopulmonary arrest. Early administration of epinephrine, which is the treatment of choice to treat anaphylaxis, may prevent the progression of an SR to a more serious life-threatening problem. Although there is little debate about using epinephrine to treat a SCIT SR, there is a lack of consensus about when it should be first used. A uniform classificatio...

IgE-mediated anaphylaxis to pristinamycin - report of a case

Allergy — Thu, 04 Feb 2010 00:00:00 +0100

(Source: Allergy)

Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly

Allergy — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: Our data confirm serum tryptase as a risk factor for severe anaphylactic reaction to hymenoptera stings. Furthermore, we give first evidence that basal serum tryptase levels increase continuously with age and being an indicator for either increased mast cell load or reactivity this can at least partly be responsible for the observed aggravated allergic reactions in elderly people. As those patients are at increased risk for life-threatening anaphylactic reactions, it should be considered to adjust VIT especially in elderly patients with elevated tryptase levels as recommended for patients with mastocytosis by increasing venom doses during VIT and by considering its life-long continuation. (Source: Allergy)

Key advances in mechanisms of asthma, allergy, and immunology in 2009

Journal of Allergy and Clinical Immunology — Mon, 01 Feb 2010 00:00:00 +0100

The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential...

Stimulation of human T cells with sulfonamides and sulfonamide metabolites

Journal of Allergy and Clinical Immunology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: Nitroso sulfonamide metabolites form potent antigenic determinants for T cells from hypersensitive patients. T-cell responses against drugs (metabolites) bound directly to MHC or MHC/peptide complexes can occur through cross-reactivity with the haptenic immunogen. (Source: Journal of Allergy and Clinical Immunology)

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Voluntarily reported unintentional injections from epinephrine auto-injectors

Journal of Allergy and Clinical Immunology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusion: The number of reported unintentional injections from epinephrine auto-injectors increased annually from 1994 to 2007. To prevent these unintentional injections, improved epinephrine auto-injector design is needed, along with increased vigilance in training the trainers and in training and coaching the users, as well as efforts to increase public awareness of the role of epinephrine auto-injectors in the first-aid treatment of anaphylaxis in the community. (Source: Journal of Allergy and Clinical Immunology)

Differential roles for the IL-9/IL-9 receptor α-chain pathway in systemic and oral antigen–induced anaphylaxis

Journal of Allergy and Clinical Immunology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: Parenteral antigen–induced murine systemic anaphylaxis is mediated by both IgG- and IgE-dependent pathways, and both can occur independently of IL-9/IL-9R signaling. In contrast, oral antigen–induced intestinal and systemic anaphylaxis is strictly IgE mediated and requires IL-9/IL-9R signaling. These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen–induced anaphylaxis. (Source: Journal of Allergy and Clinical Immunology)

Hyaluronidase allergy: A rare cause of periorbital inflammation.

The Australasian Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Borchard K, Puy R, Nixon R Hyaluronidase is a bovine or ovine testicular protein that is used as an adjunct to co-administered medicaments and fluids to enhance their dispersion and absorption through the degradation of hyaluronan. While it is a known potential allergen, there are few reports of hyaluronidase hypersensitivity. A 56-year-old lady presented 8 hours post glaucoma surgery with ipsilateral lacriminorrhoea, periorbital erythema, oedema, proptosis, pruritis and conjunctival chemosis. Right ocular motility was restricted and visual acuity was reduced. The reaction settled with oral corticosteroids and antihistamines. Hyaluronidase allergy was confirmed on skin prick testing. Hyaluronidase allergy is rare. In the few cases reported, reactions occurred at various doses ...

Food-dependent anaphylaxis with serum IgE immunoreactive to dairy products containing high-molecular-weight proteins

Journal of Dermatological Science — Thu, 28 Jan 2010 14:12:54 +0100

Food-induced anaphylaxis is one of the most common causes of anaphylaxis . Establishing the cause of recurrent anaphylaxis is one of the most important goals of management because identification of the responsible allergens allows avoidance of further exposure. (Source: Journal of Dermatological Science)

Budesonide/formoterol: Anaphylaxis: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

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Carboplatin: Anaphylaxis in an infant: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Dimethyl sulfoxide: Various toxicities including renal failure, anaphylaxis and arrhythmia: 3 case reports

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Eculizumab: Possible anaphylaxis (first report) in an elderly patient: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Lidocaine: Anaphylaxis: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Piperacillin: Anaphylaxis: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

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Severe anaphylaxis to the antiseptic polyhexanide

Allergy — Sat, 23 Jan 2010 00:00:00 +0100

(Source: Allergy)

Development and validation of a SYBR Green I-based real-time polymerase chain reaction method for detection of haptoglobin gene deletion in clinical materials.

Transfusion — Fri, 22 Jan 2010 00:00:00 +0100

CONCLUSION: The detection rate of the HP(del) allele by the SYBR Green I-based method is comparable with that using the TaqMan-based method. This method is readily applicable due to its low initial cost and analyzability using economical real-time PCR machines and is suitable for high-throughput analysis as an alternative method for allelic discrimination of HP(del). PMID: 20113448 [PubMed - as supplied by publisher] (Source: Transfusion)

FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease

American Journal of Hematology — Wed, 20 Jan 2010 00:00:00 +0100

On June 30, 2009, the United States Food and Drug Administration (FDA) approved ferumoxytol (FerahemeTM injection, AMAG Pharmaceuticals), an iron-containing product for intravenous (IV) administration, for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD). The safety and efficacy of ferumoxytol were assessed in three randomized, open-label, controlled clinical trials. Two trials evaluated patients with nondialysis dependent CKD and a third trial assessed patients undergoing hemodialysis. Randomization was either to ferumoxytol or oral iron. Ferumoxytol was administered as two 510 mg IV injections, separated by 3-8 days. Oral iron, Ferro-Sequels®, was administered at a dose of 100 mg twice daily for 21 days. In all three clinical trials, ferumoxyto...

Varicella vaccines: Anaphylaxis in a child due to gelatin excipient: case report

Reactions — Tue, 19 Jan 2010 14:09:29 +0100

(Source: Reactions)

Systemic anaphylaxis caused by moxifloxacin.

Allergologia et Immunopathologia — Mon, 18 Jan 2010 00:00:00 +0100

Authors: Sánchez-Morillas L, Rojas Pérez-Ezquerra P, Reaño-Martos M, Laguna-Martínez JJ, Gómez-Tembleque P PMID: 20089346 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Induction of Tolerance to Warfarin after Anaphylaxis with a Desensitization Protocol

Karger Publishers — Fri, 15 Jan 2010 23:00:00 +0100

Cardiology 2010;115:174175 (DOI:10.1159/000275922) (Source: Karger Publishers)

Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

Immunologic Research — Fri, 15 Jan 2010 00:47:37 +0100

Abstract Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation. Content Type Journal ArticleDOI 10.1007/s12...

Cow's milk protein allergy in children: a practical guide

BioMed Central — Fri, 15 Jan 2010 00:00:00 +0100

A joint study group on cow's milk allergy was convened by the Emilia-Romagna Working Group for Paediatric Allergy and by the Emilia-Romagna Working Group for Paediatric Gastroenterology (EWGPAG) to focus best practice for diagnosis, management and follow-up of cow's milk allergy in children and to offer a common approach for allergologists, gastroenterologists, general paediatricians and primary care physicians.The report prepared by the study group was discussed by members of Working Groups who met three times in Italy. This guide is the result of a consensus reached in the following areas. Cow's milk allergy should be suspected in children who have immediate symptoms such as acute urticaria/angioedema, wheezing, rhinitis, dry cough, vomiting, laryngeal edema, acute asthma with severe res...

Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-β-associated mechanisms

Clinical and Experimental Allergy — Thu, 14 Jan 2010 00:00:00 +0100

In this study, we built on the information obtained from the recent identification of three immunodominant T cell epitopes of hen ovalbumin (OVA), a major egg allergen, to assess the therapeutic potential of PIT for food allergy, using the BALB/c mouse model. Groups of mice were sensitized to OVA by repeated oral gavages, and subsequently administered with single or multiple synthetic peptides containing OVA T cell epitopes. Following the peptide administration period, all mice were orally challenged with high doses of OVA to elicit active anaphylaxis. Serum, spleen, and intestinal tissues were collected for the determination of immunoglobulin levels, cytokine secretions, and intestinal gene expression. Significantly lower anaphylactic scores were exhibited by mice that received multiple e...

[Anaphylactic shock due to patent blue: Four case report and review of literature.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Thu, 14 Jan 2010 00:00:00 +0100

CONCLUSION: We find an incidence of 1.06% of allergy but only 0.25% of anaphylactic shock (grade III). These rare but serious cases must weigh up the benefits and risks of using blue dye. We suggest using blue dye injection only in case of radioisotope detection failure. Of course, this approach must be evaluated. PMID: 20079974 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

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Cefotiam: Anaphylaxis followed by stress-induced cardiomyopathy (first report): case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Epinastine: Anaphylaxis associated with benzalkonium chloride excipient: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Hydroxyzine: First report of anaphylaxis: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Infliximab: Anaphylaxis and bilateral parotidomegaly: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Measles mumps and rubella virus vaccine/varicella vaccine: Anaphylaxis in a child due to gelatin excipient: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

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Propofol: Anaphylaxis: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Sciele Introduces Adrenaclick™ (epinephrine Injection, USP) Auto-Injector For The Emergency Treatment Of Anaphylaxis

Health News from Medical News Today — Mon, 11 Jan 2010 11:00:00 +0100

Sciele Pharma, Inc., a Shionogi company, today announced the U.S. availability of Adrenaclick™, a single-dose, epinephrine auto-injector for the emergency treatment for severe allergic reactions (Type I) such as anaphylaxis. Adrenaclick™ will be available as a single unit or a convenient Two-Pack. It is also available in two dosing options (0.15 mg and 0.3 mg). Adrenaclick™ delivers epinephrine, the drug of choice for anaphylactic reactions, with the use of an auto-injector... (Source: Health News from Medical News Today)

Sciele Introduces Adrenaclick™ (epinephrine Injection, USP) Auto-Injector For The Emergency Treatment Of Anaphylaxis

Allergy News From Medical News Today — Mon, 11 Jan 2010 11:00:00 +0100

Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens

Journal of Allergy and Clinical Immunology — Mon, 11 Jan 2010 00:00:00 +0100

Conclusion: Use of single kiwifruit allergen ImmunoCAP increases the quantitative test performance and diagnostic sensitivity compared with the commercial extract. Bet v 1 homolog and profilin are important allergens in pollen-related kiwifruit allergy, whereas actinidin is important in monoallergy to kiwifruit, in which symptoms are often more severe. (Source: Journal of Allergy and Clinical Immunology)

Anaphylaxis and Mast Cell Disease: What Is the Risk?

Current Allergy and Asthma Reports — Thu, 07 Jan 2010 22:26:36 +0100

Abstract Mastocytosis is a proliferative disorder of the hematopoietic mast cell progenitor that results from expansion of a clone carrying the D816V c-kit mutation. Based on the dramatic increase in incidence of anaphylaxis in patients with mastocytosis, recent studies analyzed the presence of clonal mast cell markers, including D816V c-kit mutation, in patients with recurrent IgE- and non-IgE-mediated anaphylaxis. These studies demonstrated the presence of an aberrant mast cell clone in a significant proportion of patients with unexplained anaphylaxis, or anaphylaxis due to hymenoptera venom. Clonal mast cell disease should be suspected in particular in patients presenting with profound cardiovascular manifestations such as hypotension and syncope in the absence of urtica...

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Suspected recurrent anaphylaxis in different forms during general anesthesia

Journal of Anesthesia — Tue, 05 Jan 2010 17:06:01 +0100

We report on a patient who presented with recurrent severe shock during general anesthesia. The patient was a man scheduled for lung surgery whose first attack was a coronary spasm, which was followed by a second shock with severe bronchospasm and hypotension 4 weeks later. An elevated serum tryptase concentration was observed, and subsequent skin testing revealed negative reactions to some drugs administered in this case. This case serves to alert anesthetists to the possibility of some different forms of allergy and highlights the importance of rigorous investigation of all the reagents and phenomena. Content Type Journal ArticleCategory Clinical ReportDOI 10.1007/s00540-009-0839-zAuthors Hirokazu Imanishi, Saitama Medical University Department of Anesthesiology, Saitama In...

CMR2009: 6.02: Imaging in vivo during anaphylactic shock

Contrast Media and Molecular Imaging — Tue, 05 Jan 2010 00:00:00 +0100

No Abstract. (Source: Contrast Media and Molecular Imaging)

Recalls and Safety Alerts: Preventing Anaphylactic-type Reactions with Dexferrum

Food and Drug Adminstration (FDA): Patient Safety News — Fri, 01 Jan 2010 05:00:00 +0100

American Regent has issued new precautionary measures for preventing anaphylactic-type reactions when administering Dexferrum (iron dextran injection). An updated boxed warning for Dexferrum now says that a test dose should be administered befor... (Source: Food and Drug Adminstration (FDA): Patient Safety News)

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009

Journal of Allergy and Clinical Immunology — Fri, 01 Jan 2010 00:00:00 +0100

This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects, as well as advances in allergic skin disease that were reported in the Journal in 2009. Among key epidemiologic observations, several westernized countries report that more than 1% of children have peanut allergy, and there is some evidence that environmental exposure to peanut is a risk factor. The role of regulatory T cells, complement, platelet-activating factor, and effector cells in the development and expression of food allergy were explored in several murine models and human studies. Delayed anaphylaxis to mammalian meats appears to be related to IgE binding to the carbohydrate moiety galactose-α-1,3-galactose, which also has implications for hypersensiti...

Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics

Journal of Allergy and Clinical Immunology — Fri, 01 Jan 2010 00:00:00 +0100

Conclusion: The majority of children considered peanut-sensitized on the basis of standard tests do not have peanut allergy. Component-resolved diagnostics may facilitate the diagnosis of peanut allergy. (Source: Journal of Allergy and Clinical Immunology)

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Do indications to sublingual immunotherapy need to be revised?

Journal of Allergy and Clinical Immunology — Fri, 01 Jan 2010 00:00:00 +0100

To the Editor: The report by Cochard and Eigenmann highlights an important aspect of sublingual immunotherapy (SLIT): its safety in patients with previous reactions to subcutaneous immunotherapy. They describe 2 patients who withdrew from SLIT for repeated side effects with bronchial and nasal reactions, respectively. In both of them, previous subcutaneous immunotherapy treatment had to be discontinued for adverse reactions. This confirms a recent report on 2 patients with similar characteristics who had stopped subcutaneous immunotherapy because of adverse reactions and also had severe, anaphylactic reactions to SLIT. To complicate the issue, in all these patients, SLIT was not performed by conventional schedules: in the first case, an ultrarush schedule using the product Staloral 300 (S...

Sudden cardiac death under anesthesia in pediatric patient with Williams syndrome: a case report and review of literature.

Annals of Cardiac Anaesthesia — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Gupta P, Tobias JD, Goyal S, Miller MD, Melendez E, Noviski N, De Moor MM, Mehta V Williams syndrome is a complex syndrome characterized by developmental abnormalities, craniofacial dysmorphic features, and cardiac anomalies. Sudden death has been described as a very common complication associated with anesthesia, surgery, and procedures in this population. Anatomical abnormalities associated with the heart pre-dispose these individuals to sudden death. In addition to a sudden and rapid downhill course, lack of response to resuscitation is another significant feature seen in these patients. The authors report a five-year-old male with Williams syndrome, hypothyroidism, and attention deficit hyperactivity disorder. He suffered an anaphylactic reaction during CT imaging with con...

[Cutaneous events during anti-TNF alpha therapy: A prospective observational study of 41 cases.]

Annales de Dermatologie et de Cenereologie — Fri, 01 Jan 2010 00:00:00 +0100

This study confirms the multiple clinical dermatological situations observed in patients treated with TNFalpha inhibitors and illustrates the need for good coordination between dermatologists and other specialists in order to ensure optimal management of this population. PMID: 20110063 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

Anti-allergic Effects of Fermented Ixeris sonchifolia and Its Constituent in Mice.

Journal of Microbiology and Biotechnology — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Trinh HT, Bae EA, Hyun YJ, Jang YA, Yun HK, Hong SS, Kim DH To evaluate the antiallergic effect of fermented Ixeris sonchifolia (IS, family Compositae), we prepared IS Kimchi, isolated Lactic acid bacteria (LAB) from it, fermented IS with these LAB, and investigated their antiallergic effects. IS Kimchi more potently inhibited the passive cutaneous anaphylaxis (PCA) reaction induced by an IgE-antigen complex as well as the scratching behavior induced by compound 48/80 or histamine than IS. When IS was fermented with LAB isolated from IS Kimchi, its antiallergic effects was also increased. Of LAB used for fermentation, Lactobacillus brevis more potently increased the antiallergic effects. Its main constituents, chlorogenic acid and luteolin potently inhibited PCA reaction induc...

Allergen immunotherapy-induced biphasic systemic reactions: incidence, characteristics, and outcome: a prospective study.

Annals of Allergy, Asthma and Immunology — Fri, 01 Jan 2010 00:00:00 +0100

CONCLUSIONS: Immunotherapy-induced BRs are uncommon. They tend to be mild and might be more common in patients with a low baseline PEF or concomitant asthma. Therefore, a long observation after the initial reaction is not required. PMID: 20143649 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

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Anaphylaxis in the obstetric patient: analysis of a statewide hospital discharge database.

Annals of Allergy, Asthma and Immunology — Fri, 01 Jan 2010 00:00:00 +0100

CONCLUSIONS: Anaphylaxis during pregnancy is a rare event. In this large case series, we found that beta-lactam antibiotics were the most common triggers of anaphylaxis. PMID: 20143646 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Clinical features of hypersensitivity reactions to oxaliplatin among Chinese patients with colorectal cancer.

Ai Zheng — Thu, 31 Dec 2009 11:48:20 +0100

Conclusion: Oxaliplatin-induced allergic reactions occurred in Chinese patients with CRC, and the incidence rate, occurrence time, degree of severity, and clinical outcome were consistent with literature published abroad. PMID: 20038320 [PubMed - in process] (Source: Ai Zheng)

Allergenicity of Carbohydrates and Their Role in Anaphylactic Events

Current Allergy and Asthma Reports — Thu, 24 Dec 2009 19:49:42 +0100

Abstract The IgE response to pollen allergens often includes IgE antibodies specific for glycosylation motifs on the pollen proteins. These oligosaccharides are present on many different species and are known as cross-reactive carbohydrate determinants. However, IgE antibodies to plant-derived cross-reactive carbohydrate determinants seem to have only minor clinical significance and have not been related to anaphylaxis. Recently, two novel forms of anaphylaxis have become apparent in the southeastern United States: 1) reactions during the first infusion of the monoclonal antibody cetuximab and 2) adult-onset delayed anaphylaxis to red meat. Detailed investigation of serum antibodies established that in both cases, the patients had IgE antibodies specific for the mammalian o...

Gaps in anaphylaxis management at the level of physicians, patients, and the community: a systematic review of the literature

Allergy — Mon, 21 Dec 2009 00:00:00 +0100

To cite this article: Kastner M, Harada L, Waserman S. Gaps in anaphylaxis management at the level of physicians, patients, and the community: a systematic review of the literature. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02294.x. Diagnosis and management of anaphylaxis can be a challenge because reactions are often unexpected and progress quickly. The focus of anaphylaxis management has mostly been on the acute episode, with little attention given to the long-term management of patients at risk. This is compounded by conflicting information in current guidelines and a general lack of agreement among clinicians about which management strategies are the most appropriate. We systematically reviewed the literature to identify and summarize studies that investigated gaps in anaphylaxis man...

Management of patients with factor V deficiency: open issues from the challenging history of a woman with anaphylactic transfusion reactions

Haemophilia — Sun, 20 Dec 2009 00:00:00 +0100

(Source: Haemophilia)

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Primary hydatidosis of the central nervous system: A retrospective study of 39 Tunisian cases

Clinical Neurology and Neurosurgery — Wed, 16 Dec 2009 16:10:20 +0100

Conclusion: Despite all the advances in imaging techniques and therapeutic methods, central nervous system hydatidosis remains difficult to cure and patient outcomes are not satisfactory especially in case of spinal involvement due to the high incidence of recurrence. (Source: Clinical Neurology and Neurosurgery)

What Are Insect Bites? How To Treat Insect Bites

Health News from Medical News Today — Wed, 16 Dec 2009 13:00:00 +0100

Insect bites are puncture wounds or lacerations made by insects. An insect may bite when it is agitated and defends itself, or when it wants to feed. Insects typically inject formic acid, which can trigger a reaction, including redness, swelling, pain or itching. Fire ants, bees, wasps and hornets have a painful sting which can trigger a potentially dangerous allergic reaction (anaphylaxis) for some people. A wasp may either bite or sting. Bites from fleas, mites and mosquitoes tend to cause itching rather than pain. The rest of this article is about insect bites, not insect stings... (Source: Health News from Medical News Today)

Anaphylaxis to Wheat Flour-Derived Foodstuffs and the Lipid Transfer Protein Syndrome: A Potential Role of Wheat Lipid Transfer Protein Tri a 14

International Archives of Allergy and Immunology — Tue, 15 Dec 2009 23:00:00 +0100

Int Arch Allergy Immunol 2010;152:178-183 (DOI:10.1159/000265539) (Source: International Archives of Allergy and Immunology)

Amoxicillin/suxamethonium chloride: Maternal anaphylaxis leading to fetal bradycardia: 2 case reports

Reactions — Tue, 15 Dec 2009 14:08:48 +0100

(Source: Reactions)

Suxamethonium chloride: Anaphylaxis: case report

Reactions — Tue, 15 Dec 2009 14:08:48 +0100

(Source: Reactions)

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Clopidogrel Hypersensitivity: A Novel Multi-Day Outpatient Oral Desensitization Regimen(January).

The Annals of Pharmacotherapy — Tue, 15 Dec 2009 00:00:00 +0100

CONCLUSIONS: This outpatient 10-dose multi-day clopidogrel desensitization protocol is a safe and effective novel approach for the treatment of clopidogrel hypersensitivity in patients with coronary artery disease and cardiac stent placement. In addition to safety and efficacy, this protocol offers the patient the convenience of avoiding hospital admission or full-day time commitments. PMID: 20009004 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Latex allergy.

American Family Physician — Tue, 15 Dec 2009 00:00:00 +0100

Authors: Pollart SM, Warniment C, Mori T The prevalence of latex allergy in the general population is low; however, the risk of developing latex allergy is higher in persons with increased latex exposure, such as health care workers or persons who work in the rubber industry. Children with spina bifida and others who undergo multiple surgeries or procedures, particularly within the first year of life, are also at greater risk of latex allergy. Reactions to latex allergy can range from type IV delayed hypersensitivity (e.g., contact dermatitis) to type I immediate hypersensitivity (e.g., urticaria, bronchospasm, anaphylaxis). Latex allergy can be diagnosed with clinical history, skin prick testing, latex-specific serum immunoglobulin E testing, and glove provocation testing. The main go...

Charity warns on adrenaline injector expiry

HealthcareRepublic Independent Nurse News — Mon, 14 Dec 2009 00:05:00 +0100

Patients at risk of anaphylaxis should check their adrenaline injectors have not passed their expiry date, the Anaphylaxis Campaign charity has warned. (Source: HealthcareRepublic Independent Nurse News)

Cost-Effectiveness of Universal Prophylaxis in Pregnancy with Prior Group B Streptococci Colonization

Infectious Diseases in Obstetrics and Gynecology — Sun, 13 Dec 2009 14:40:30 +0100

Conclusion. Universal treatment of term pregnancies with a history of previous GBS colonization is more cost-effective than the strategy of screening and treating based on positive culture results. (Source: Infectious Diseases in Obstetrics and Gynecology)

Handle with care ... nitroglycerin anaphylaxis

Annals of Allergy, Asthma and Immunology — Sat, 12 Dec 2009 13:38:31 +0100

(Source: Annals of Allergy, Asthma and Immunology)

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Topical bovine thrombin: a 21-year review of topical bovine thrombin spontaneous case safety reports submitted to FDA's Adverse Event Reporting System

Pharmacoepidemiology and Drug Safety — Sat, 12 Dec 2009 00:00:00 +0100

To review topical bovine thrombin spontaneous adverse event (AE) reports that were forwarded to the US Food and Drug Administration's (FDA) Adverse Event Reporting System (AERS) between January 1986 and December 2006.Forty-one spontaneous AE reports were summarized for reported AE profile and chronological reporting patterns. Each AE report was adjudicated by a hematologist for the topical bovine thrombin product that was given and the AE(s) that were reported. AEs were grouped as allergic, coagulopathy/bleeding, and all other AEs combined. Grouped AE serial analyses were carried out using successive 3-year time increments between 1986 (the year an AE report was first noted for a bovine thrombin product) and 2006 (the first full year that was available at the time of initiation of the data...

Diagnostic Utility of Two Case Definitions for Anaphylaxis: A Comparison Using a Retrospective Case Notes Analysis in the UK

Drug Safety — Fri, 11 Dec 2009 14:01:33 +0100

(Source: Drug Safety)

IgE-mediated anaphylaxis to Hippobosca equina in a patient with systemic mastocytosis

Allergy — Fri, 11 Dec 2009 00:00:00 +0100

(Source: Allergy)

Anaphylaxis Campaign advises check of expiry date of adenaline Epipens

NeLM - Immunology and vaccination — Thu, 10 Dec 2009 00:00:00 +0100

Source: BBC Health News Area: News The Anaphylaxis Campaign is urging the 210,000 British people who carry adrenaline Epipens to check the expiry date if they have not already done so as many are due to expire in January 2010. Most pens in the UK are US-made Epipens and tend to arrive in one large batch with the same expiry date. Many pens, which have a shelf-life of 18 months, were prescribed in the summer of 2008 and all came from the same batch with the January expiry date. (Source: NeLM - Immunology and vaccination)

Lupine, a source of new as well as hidden food allergens

Molecular Nutrition — Thu, 10 Dec 2009 00:00:00 +0100

The present review summarizes current knowledge about lupine allergy, potential sensitization routes, cross-reactions between lupine and other legumes, and the respective IgE-binding proteins. Since the 1990s, lupine flour is used as a substitute for or additive to other flours, mostly wheat flour, in several countries of the EU. In 1994, the first case of an immediate-type allergy after ingestion of lupine flour-containing pasta was reported. Since then, the number of published incidents following ingestion or inhalation of lupine flour is rising. So far, the Lupinus angustifolius [beta]-conglutin has been designated as the allergen Lup an 1 by the International Union of Immunological Societies Allergen Nomenclature Subcommittee. Initially, publications focussed on the fact that peanut-al...

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More than Half of Patients With Anaphylaxis Delay Seeking Medical Attention

Medscape Today Headlines — Tue, 08 Dec 2009 17:57:10 +0100

Patients using self-injectable epinephrine reported a median delay of 38 minutes from symptom onset to administration of treatment. Medscape Medical News (Source: Medscape Today Headlines)

Ultra-short course immunotherapy in children and adolescents during a 3-yrs post-marketing surveillance study

Pediatric Allergy and Immunology — Tue, 08 Dec 2009 00:00:00 +0100

Rosewich M. Ultra-short course immunotherapy in children and adolescents during a 3-yrs post-marketing surveillance study.Pediatr Allergy Immunol 2009.© 2009 John Wiley & Sons A/S Ultra-short course immunotherapy (uSCIT) has shown good efficacy and tolerability in children and adolescents with seasonal allergic rhinitis (SAR), conjunctivitis and/or asthma in clinical studies. Here, we investigate the efficacy of uSCIT in the juvenile subpopulation of a 3-year post-marketing surveillance (PMS) study. To assess the differences in the efficacy of uSCIT between adults and children respectively adolescents enrolled in a PMS study. In a prospective open study 422 patients aged 6[ndash]18 years with SAR, conjunctivitis and/or asthma received four pre-seasonal injections with pollen allergoids fo...

Chlorhexidine/silver sulfadiazine: Anaphylaxis following insertion of impregnated central venous catheters: 3 case reports

Reactions — Mon, 07 Dec 2009 14:04:26 +0100

(Source: Reactions)

Dexamethasone: Anaphylaxis in an elderly patient: case report

Reactions — Mon, 07 Dec 2009 14:04:26 +0100

(Source: Reactions)

Natalizumab: Acute anaphylactic reaction: case report

Reactions — Mon, 07 Dec 2009 14:04:26 +0100

(Source: Reactions)

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Pristinamycin: IgE-mediated anaphylaxis: 3 case reports

Reactions — Mon, 07 Dec 2009 14:04:26 +0100

(Source: Reactions)

Suxamethonium chloride: Anaphylaxis and rhabdomyolysis: case report

Reactions — Mon, 07 Dec 2009 14:04:26 +0100

(Source: Reactions)

Entocort CR 3 mg capsules and enema (budesonide) - Revised SPC

NeLM - SPC Changes — Mon, 07 Dec 2009 00:00:00 +0100

Source: Manufacturer notification Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.4 (Special warnings and precautions for use) - Particular care is required when considering the use of systemic corticosteroids in patients with existing or previous history of severe affective disorders in themselves or in their first degree relatives. Systemic effects of steroids may occur, particularly when prescribed at high doses and for prolonged periods. Such effects may include Cushing's syndrome, adrenal suppression, growth retardation, decreased bone mineral density, cataract, glaucoma and very rarely a wide range of psychiatric/behavioural effects (see Section 4.8) Section 4.8 (Undesirable effects) Very rarely a wide range of psychiatric/ behavioural effe...

In Defense of Antimicrobial Prophylaxis for Prevention of Infective Endocarditis in Patients With Hypertrophic Cardiomyopathy

Journal of the American College of Cardiology — Sat, 05 Dec 2009 13:49:00 +0100

We read with particular interest Bach's viewpoint editorial and critique () of the recent American Heart Association (AHA) revised recommendations for antimicrobial prevention of infective endocarditis (). The “new” recommendations, which represent a striking change from the original guidelines followed for more than 50 years (), are based largely on 2 risk versus benefit assumptions: 1) significant mortality or morbidity (e.g., anaphylaxis) associated with prophylactic antibiotic therapy; and 2) a lack of evidence (particularly, randomized trials) supporting the efficacy of antibiotic prophylaxis in the prevention of infective endocarditis. (Source: Journal of the American College of Cardiology)

Feds say 48 cases of anaphylaxis after H1N1 shots

CTV Health — Fri, 04 Dec 2009 19:02:11 +0100

The Public Health Agency of Canada says there have been 48 cases of a severe allergic reaction reported in people who have had H1N1 shots. (Source: CTV Health)

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Endo Pharmaceuticals Provides Regulatory Update On AVEED(TM) (Testosterone Undecanoate) Injection

Health News from Medical News Today — Fri, 04 Dec 2009 11:00:00 +0100

Endo Pharmaceuticals (Nasdaq: ENDP) announced that it received a complete response letter from the U.S. Food and Drug Administration (FDA) regarding the New Drug Application (NDA) for its extended-duration testosterone undecanoate injection, AVEED(TM), for men diagnosed with low testosterone. Low testosterone is also known as hypogonadism. In the complete response letter, the FDA has requested information from Endo to address the agency's concerns regarding very rare but serious adverse events, including post-injection anaphylactic reaction and pulmonary oil microembolism... (Source: Health News from Medical News Today)

Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children

Journal of Allergy and Clinical Immunology — Tue, 01 Dec 2009 00:00:00 +0100

Conclusion: Older age and reactions to peanuts were risk factors for anaphylaxis during oral food challenges. Reactions requiring multiple doses of epinephrine and biphasic reactions were infrequent. (Source: Journal of Allergy and Clinical Immunology)

Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5− TH2 responses

Journal of Allergy and Clinical Immunology — Tue, 01 Dec 2009 00:00:00 +0100

Conclusion: TH2 responses are composed of 2 subpopulations: IL-5+ TH2 and IL-5– TH2 cells. IL-5+ TH2 food allergen–specific T cells are singularly associated with AEG, whereas PA is associated with a dominant IL-5– TH2 response. These results suggest heterogeneity within the TH2 cytokine response, with different TH2 responses alternatively favoring IgE-mediated or eosinophil-dominant immunopathology. (Source: Journal of Allergy and Clinical Immunology)

Eosinophilic cellulitis after honeybee sting.

J Formos Med Assoc — Tue, 01 Dec 2009 00:00:00 +0100

We report a 45-year-old female patient who was stung by a honeybee, and whose right forearm showed progressive swelling with bullous formation after the sting. She was sent to our emergency department with the diagnosis of right hand cellulitis. After treatment with antibiotics for 5 days, the lesions showed no response. Then, systemic steroid was used and the lesion gradually resolved. Diagnosis of Wells syndrome was made according to clinical appearance, course and characteristic histopathological findings. PMID: 20040462 [PubMed - in process] (Source: J Formos Med Assoc)

Influence of hyperosmotic conditions on basophil CD203c upregulation in patients with food-dependent exercise-induced anaphylaxis.

Annals of Agricultural and Environmental Medicine : AAEM — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Wolanczyk-Medrala A, Barg W, Gogolewski G, Panaszek B, Liebhart J, Litwa M, Medrala W Increased in vitro basophil activation in buffers of slightly elevated osmolarity in 2 cases of food-dependent exercise-induced anaphylaxis is presented. These data may suggest the importance of basophil activation degree in pathogenesis of this life threatening syndrome. PMID: 20047266 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)

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Handle with care ... nitroglycerin anaphylaxis.

Annals of Allergy, Asthma and Immunology — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Weiss L, Brady N, Hostoffer RW, Tcheurekdjian H PMID: 20084849 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Regional variation in epinephrine autoinjector prescriptions in Australia: more evidence for the vitamin D-anaphylaxis hypothesis.

Annals of Allergy, Asthma and Immunology — Tue, 01 Dec 2009 00:00:00 +0100

CONCLUSIONS: EpiPen prescription rates and anaphylaxis admissions are more common in southern regions of Australia. These data provide additional support for a possible role of vitamin D in the pathogenesis of anaphylaxis. PMID: 20084842 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

Looking Ahead in Dermatology: Skin and Allergy.

Actas Dermo-Sifiliograficas — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Ring J, Belloni B, Behrendt H The prevalence of allergic diseases has increased tremendously over the last decades. Clinically they comprise a spectrum of many different conditions caused by specific immunological hypersensitivity in response to a mostly apathogenic substance. Environmental factors such as lack of immune-stimulating contacts (infection, vaccination) and exposure to allergy-enhancing anthropogenic pollutants from tobacco smoke or traffic exhaust particles are suspected to be involved in the increase of allergies. Recently it has been shown that pollens are not only allergen carriers but also secrete highly active proinflammatory lipid mediators, pollen-associated lipid mediators (PALMs), which have proinflammatory and immuno-modulatory capacity that facilitates...

Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice.

Archives of Pharmacal Research — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Trinh HT, Bae EA, Lee JJ, Kim DH To understand anti-allergic effect of Curcuma aromatica (family Zingerberaceae), which inhibited passive cutenous anaphylaxis (PCA) reaction in preliminary study, we isolated its main constituents, curcumin, demethoxycurcumin and bisdemethoxycurcumin, and investigated their inhibitory effects against PCA reaction and scratching behavior. These curcuminoids inhibited the PCA reaction induced by the IgE-antigen complex (IAC) and the scratching behavior induced by compound 48/80. These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and IL-4, and transcription factor NF-kappaB activation in IAC-induced RBL-2H3 cells. Of these curcuminoids, curcumin exhibited the most potent inhibition, followed by demethoxycurcumin and b...

Canada Probes H1N1 Vaccine Anaphylaxis Spike

MedPage Today Geriatrics — Mon, 30 Nov 2009 21:48:13 +0100

Canadian health officials are continuing to investigate a spike in anaphylaxis associated with one batch of the country's H1N1 vaccine, made by GlaxoSmithKline. (Source: MedPage Today Geriatrics)

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sanofi-aventis U.S. and Intelliject, Inc. Sign Licensing Agreement for Novel Epinephrine Auto Injector in North America

HSMN NewsFeed — Mon, 30 Nov 2009 18:46:58 +0100

BRIDGEWATER, N.J., Nov. 30 (HSMN NewsFeed) -- sanofi-aventis U.S. announced today the signing of an exclusive licensing agreement with Intelliject, Inc. for a novel epinephrine auto injector for the emergency treatment of allergic reactions (anaphylaxis)... Devices, Biopharmaceuticals, Drug Delivery, Licensingsanofi-aventis, Intelliject, epinephrine, injector (Source: HSMN NewsFeed)

Etoposide: Anaphylaxis: case report

Reactions — Mon, 30 Nov 2009 14:07:30 +0100

(Source: Reactions)

Factor VIII inhibitor bypassing fraction/octocog-/von-Willebrand factor: Anaphylaxis in an elderly patient: case report

Reactions — Mon, 30 Nov 2009 14:07:30 +0100

(Source: Reactions)

H1N1 Update: Anaphylaxis, Drug Resistance, Mutations

Physician's First Watch current issue — Mon, 30 Nov 2009 12:47:22 +0100

(Source: Physician's First Watch current issue)

Policy Pack Helps Schools Support Children With Health Conditions, UK

Health News from Medical News Today — Mon, 30 Nov 2009 09:00:00 +0100

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Policy Pack Helps Schools Support Children With Health Conditions, UK

Pediatrics News From Medical News Today — Mon, 30 Nov 2009 09:00:00 +0100

Eight out of 10 schools surveyed in England have created or amended their medical policies since receiving the 'Medical Conditions at School: Policy Pack' created jointly by Diabetes UK, Asthma UK, the Anaphylaxis Campaign and Epilepsy Action. The survey of 300 schools also showed that more than three quarters of respondents who have used the pack feel that it has already had a positive impact on staff, pupils or parents. (Source: Pediatrics News From Medical News Today)

Perioperative fluid therapy

Anaesthesia and intensive care medicine — Fri, 27 Nov 2009 13:40:59 +0100

Abstract: Perioperative fluid therapy remains a controversial topic despite much research. Here, we review the different types of fluids, what to use in different circumstances and some of the controversies associated with fluid use. Crystalloids are fluids with small water-soluble molecules that can easily cross semi-permeable membranes. Saline-based fluids stay mainly within the extracellular compartment. Glucose solutions provide free water that diffuses across all the fluid compartments of the body. Colloids are fluids with larger, more insoluble molecules that do not readily cross membranes. Gelatins, dextrans and hydroxyethyl starches are effective intravascular volume expanders but are associated with numerous complications including anaphylaxis, renal failure and coagulation change...

Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions

Allergy — Fri, 27 Nov 2009 00:00:00 +0100

Conclusions: This report indicates that in some patients with infliximab-related severe reactions, IgE or IgM antibodies against infliximab were detectable. The majority of reactions could be predicted by the appearance of anti-infliximab antibodies. (Source: Allergy)

Purification, crystallization and preliminary X-ray analysis of a deletion mutant of a major buckwheat allergen

Acta Crystallographica Section F — Fri, 27 Nov 2009 00:00:00 +0100

A 16 kDa buckwheat protein (BWp16) is a major allergen responsible for immediate hypersensitivity reactions including anaphylaxis. A deletion mutant of BWp16 (rBWp16ΔN) was overproduced and purified and was shown to be immunologically active. A three-wavelength MAD data set was collected from a crystal of selenomethionine-labelled rBWp16ΔN. The crystal belonged to the triclinic space group P1, with unit-cell parameters a = 28.39, b = 31.54, c = 32.20 Å, α = 111.92, β = 108.91, γ = 98.74°. One monomer was expected to be present in the asymmetric unit based on the calculated Matthews coefficient of 1.76 Å3 Da−1. (Source: Acta Crystallographica Section F)