MedWorm: Anorexia

Leptin in Anorexia and Cachexia Syndrome

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and food intake is not followed by a compensatory increase in appetite or decreased EE. Crosstalk between leptin and inflammatory signaling known to be activated in these condi...

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Family Based Treatment for Anorexia Nervosa (The Maudsley Method)

About.com Eating Disorders — Mon, 06 Feb 2012 05:00:00 +0100

An overview of family-based treatment for anorexia nervosa, also known as the Maudsley method. (Source: About.com Eating Disorders)

Register Now for National Eating Disorders Awareness Week

Psychology Today Parenting Center — Mon, 06 Feb 2012 01:43:29 +0100

Incidence of eating disorders rises; we all know someone affected. read more (Source: Psychology Today Parenting Center)

Reversal of CRF- and stress-induced anorexia by an ayurvedic formulation

Revista Brasileira de Farmacognosia — Sun, 05 Feb 2012 18:30:49 +0100

Trikatu churna is one of the commonly used Ayurvedic formulations in the traditional system of medicine in India for the treatment of agnimandya, i.e. anorexia. Trikatu contains equal amounts of finely powdered rhizomes of Zingiber officinale Roscoe (Zingiberaceae) and fruits of Piper longum L. and Piper nigrum L. (Piperaceae). The chief objective of the study was to determine the antianorectic effects of three drugs individually and to compare these effects with the effect of Trikatu. The activity of the drugs was studied after anorexia was induced in rats by (1) physical stress arising from immobilization for 60 min; (2) intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS, 100 μg/kg body weight); and (3) intraperitoneal administration of fluoxetine (8 mg/kg body weight...

[Original Articles] Event-Related Potentials During Recognition of Semantic and Pictorial Food Stimuli in Patients With Anorexia Nervosa and Healthy Controls With Varying Internal States of Hunger

Psychosomatic Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions The presented data provide evidence for a midline parietal P3b amplitude reduction in patients with AN, which might point to reduced network activation in AN even during satiety. Observed subtle recognition deficits either represent a stable trait characteristic or a "scar" effect of chronic starvation that may play a role in the development and/or persistence of the disorder. (Source: Psychosomatic Medicine)

Somatic comorbidity in anorexia nervosa: First results of a 21-year follow-up study on female inpatients

BioPsychoSocial Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Background: Anorexia nervosa is a severe psychosomatic disease with somatic complications in the long-term course and a high mortality rate. Somatic comorbidities independent of anorexia nervosa have rarely been studied, but pose a challenge to clinical practitioners. We investigated somatic comorbidities in an inpatient cohort and compared somatically ill anorexic patients and patients without a somatic comorbidity. In order to evaluate the impact of somatic comorbidity for the long-term course of anorexia nervosa, we monitored survival in a long-term follow-up.MethodOne hundred and sixty-nine female inpatients with anorexia nervosa were treated at the Charite University Medical Centre, Campus Benjamin Franklin, Berlin, between 1979 and 2011. We conducted retrospective analyses using pati...

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A Mind Less Ordinary: My Experience of Living with Anorexia and Schizoaffective Disorder [Book reviews]

The British Journal of Psychiatry — Wed, 01 Feb 2012 05:00:00 +0100

(Source: The British Journal of Psychiatry)

Calculation of Expected Body Weight in Adolescents With Eating Disorders

PEDIATRICS — Wed, 01 Feb 2012 05:00:00 +0100

CONCLUSIONS: These methods largely agree on percent EBW in terms of clinically significant cut points. However, the McLaren and Moore methods present with limitations, and a commonly agreed-upon method for EBW calculation such as the BMI percentile method is recommended for clinical and research purposes. (Source: PEDIATRICS)

Leptin treatment of patients with anorexia nervosa? The urgent need for initiation of clinical studies

European Child and Adolescent Psychiatry — Tue, 31 Jan 2012 07:04:18 +0100

Content Type Journal ArticleCategory EditorialPages 63-66DOI 10.1007/s00787-012-0243-3Authors Johannes Hebebrand, Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Virchowstr. 174, 45147 Essen, GermanyÖzgür Albayrak, Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Virchowstr. 174, 45147 Essen, Germany Journal European Child & Adolescent PsychiatryOnline ISSN 1435-165XPrint ISSN 1018-8827 (Source: European Child and Adolescent Psychiatry)

Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

Anorexia-cachexia syndrome (ACS) is a major determinant of cancer-related death that causes progressive body weight loss due to depletion of skeletal muscle mass and body fat. Here, we report the development of a novel preclinical murine model of ACS in which lymphomas harbor elevated Myc and activated mTOR signaling. The ACS phenotype in this model correlated with deregulated expression of a number of cytokines, including elevated levels of interleukin-10 which was under the direct translational control of mTOR. Notably, pharmacologic intervention to impair protein synthesis restored cytokine production to near-normal levels, delayed ACS progression, and extended host survival. Together, our findings suggest a new paradigm to treat ACS by strategies which target protein synthesis to block...

Psychosocial interventions for patients with chronic disease

BioPsychoSocial Medicine — Tue, 31 Jan 2012 05:00:00 +0100

Treatment of patients with chronic diseases will be one of the main challenges of medicine in the future. This paper presents an overview of different origins, mechanism, and symptoms necessary for understanding new and different interventions that include a psychosomatic view.In a psychosomatic therapeutic intervention there are very different targets, such as psychological symptoms, personality traits, attitudes toward disease and life, risk behaviour, and social isolation and as biological targets the change of autonomic imbalance and of the effects of the psycho-endocrinological or psycho-immunological stress responses. And there are also different psychosomatic measures that influence the individual biological, psychological and sociological targets. There is a need to give different ...

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Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation.

Physiological Research — Tue, 31 Jan 2012 05:00:00 +0100

Authors: Kaválková P, Dostálová I, Haluzíková D, Trachta P, Hanušová V, Lacinová Z, Papežová H, Domluvilová D, Zikán V, Haluzík M Abstract Preadipocyte factor-1 (Pref-1) is a member of epidermal growth-factor like family of proteins that regulates adipocyte and osteoblast differentiation. Experimental studies suggest that circulating Pref-1 levels may be also involved in the regulation of lipid and glucose metabolism and energy homeostasis. We hypothesized that alterations in Pref-1 levels may contribute to the ethiopathogenesis of anorexia nervosa or its underlying metabolic abnormalities. We measured Pref-1 concentrations and other hormonal, biochemical and anthropometric parameters in eighteen patients with anorexia nervosa and sixteen healthy women and studied the...

Small‐vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: Two subsets of giant cell arteritis

Arthritis and Rheumatism — Mon, 30 Jan 2012 13:25:25 +0100

ConclusionOur findings indicate that isolated VVV and SVV should be considered part of the histopathologic spectrum of GCA. (Source: Arthritis and Rheumatism)

Spatial orientation constancy is impaired in anorexia nervosa

Psychiatry Research — Mon, 30 Jan 2012 05:00:00 +0100

Abstract: In anorexia nervosa (AN), body distortions have been associated with parietal cortex (PC) dysfunction. The PC is also the anatomical substrate of a supramodal reference framework involved in spatial orientation constancy. Given the impaired spatial orientation constancy found in hemineglect, we sought to determine whether similar disturbances could be observed in anorexic patients. We investigated the effect of passive lateral body inclination on the tactile subjective vertical (SV). Fifty participants (25 AN patients and 25 healthy controls) were asked to manually set a rod into the vertical position under three postural conditions. For tilted conditions, we observed a significant deviation of the tactile SV towards the body. This effect was abnormally accentuated in AN patients...

Fathers, Daughters and the "Touch Taboo"

Psychology Today Parenting Center — Sun, 29 Jan 2012 22:37:42 +0100

Our culture's objectification of women and its high incidence of sexual abuse have given rise to the "touch taboo," the phenomenon of fathers halting all expressions of physical affection toward their physically maturing daughters, read more (Source: Psychology Today Parenting Center)

Maternal eating disorders and infant temperament: Findings from the norwegian mother and child cohort study

International Journal of Eating Disorders — Sat, 28 Jan 2012 05:00:00 +0100

Discussion:Mothers with eating disorders may rate their infants as more difficult because of information‐processing biases or because their infants are emotionally difficult. Maternal perception of infant temperament may be a risk factor for children's emotional development. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

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Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect?

Amino Acids — Sat, 28 Jan 2012 05:00:00 +0100

In conclusion, endotoxemia rapidly but transiently decreased the circulating concentrations of almost all AA and more durably of glutamate, glutamine and citrulline in muscle. Supplementation with glutamate or glutamine failed to restore glutamate, glutamine and citrulline concentrations in plasma and muscles. The implication of a loss of the intestinal capacity for AA absorption and/or metabolism in endotoxemia (as judged from decreased citrulline plasma concentration) for explaining such results are discussed. PMID: 22286833 [PubMed - as supplied by publisher] (Source: Amino Acids)

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

Nephrology Dialysis Transplantation — Fri, 27 Jan 2012 05:00:00 +0100

Conclusions. MIC-1/GDF15 is a novel independent serum marker of mortality in CKD capable of significantly improving the mortality prediction of other established markers. MIC-1/GDF15 may mediate protein-energy wasting in CKD and represent a novel therapeutic target for this fatal complication. (Source: Nephrology Dialysis Transplantation)

Are You Eating Your Sexual Desire?

Psychology Today Food and Diet Center — Thu, 26 Jan 2012 12:56:48 +0100

Eating is accessible and provides an immediate rush of pleasure. Eating compulsively can also put us in a kind of trance state and numb us for what we may be really wanting. This does beg the question: "Why are we substituting food for sex?"read more (Source: Psychology Today Food and Diet Center)

Adolescent male with anorexia nervosa: a case report from Iraq

Child and Adolescent Psychiatry and Mental Health — Thu, 26 Jan 2012 05:00:00 +0100

This is the first reported case of an adolescent male with anorexia nervosa in Iraq. This disorder is believed to be rare in males across cultures and uncommon for both genders in Arab countries. The patient met the DSM-IV diagnostic criteria for anorexia nervosa. He was hospitalized and received medical and psychiatric treatment at local facilities as discussed below and responded well to treatment. (Source: Child and Adolescent Psychiatry and Mental Health)

Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS:Short‐term administration of exogenous ghrelin at the start of cisplatin‐based chemotherapy stimulated food intake and minimized adverse events. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)

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An open‐label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS:Although RPI.4610 demonstrated a well‐tolerated safety profile, its lack of clinical efficacy precludes this drug from further development. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)

Treatment of Anorexia Nervosa in Children and Adolescents

Current Psychiatry Reports — Wed, 25 Jan 2012 18:14:43 +0100

Abstract In this review, we discuss the treatment of anorexia nervosa (AN) in children and adolescents, highlighting inpatient and outpatient psychiatric treatment. AN is an illness that involves medical and psychological issues; hence, treatment often requires the seamless integration of several medical professionals. It is important that the treatment model be unified and consistent as patients transition from inpatient to outpatient treatment. We briefly describe the therapeutic principles involved in treatment of AN and then give examples of how we employ these principles across treatment settings and with multiple medical professionals. Content Type Journal ArticleCategory CHILD AND ADOLESCENT DISORDERS (TD BENTON, SECTION EDITOR)Pages 1-5DOI 10.1007/s11920-012-02...

The Curious Incident of the Fish Sticks in the Nighttime

Psychology Today Food and Diet Center — Wed, 25 Jan 2012 03:54:36 +0100

Visiting hours were soon, and if I wanted to see my parents, I had to finish my dinner. I truly didn't have an out. If I didn't eat what was on my tray, I knew my doctor would order a nasogastric tube. If I refused that, he would get a court order to have one placed. So ever reluctantly, I picked up my fork and started eating.read more (Source: Psychology Today Food and Diet Center)

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

Journal of Molecular Medicine — Tue, 24 Jan 2012 06:54:52 +0100

Abstract During the last 10 years, a series of exciting observations has led to a new theory of pathophysiology using insights from evolutionary biology and neuroendocrine immunology to understand the sequelae of chronic inflammatory disease. According to this theory, disease sequelae can be explained based on redirection of energy-rich fuels from storage organs to the activated immune system. These disease sequelae are highly diverse and include the following: sickness behavior, anorexia, malnutrition, muscle wasting–cachexia, cachectic obesity, insulin resistance with hyperinsulinemia, dyslipidemia, increase of adipose tissue near inflamed tissue, alterations of steroid hormone axes, elevated sympathetic tone and local sympathetic nerve fiber loss, decreased paras...

Do the components of manualized family‐based treatment for anorexia nervosa predict weight gain?

International Journal of Eating Disorders — Tue, 24 Jan 2012 05:00:00 +0100

Discussion:The results of this study lend further support for the efficacy of the FBT, demonstrating that the principles guiding clinical practice are those which lead to weight gain. The finding that parental control is the central predictor of change can also support the development of augmentations to the model. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

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Severe anorexia nervosa in men: Comparison with severe AN in women and analysis of mortality

International Journal of Eating Disorders — Tue, 24 Jan 2012 05:00:00 +0100

Discussion:Male inpatients should receive close follow‐up after their discharge, especially if they have a restrictive form of AN, present low BMI, or are older at admission. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

Visual body perception in anorexia nervosa

International Journal of Eating Disorders — Tue, 24 Jan 2012 05:00:00 +0100

Discussion:The paradoxical advantage of patients with AN in detail‐based body processing may be associated to their tendency to routinely explore body parts as a consequence of their obsessive worries about body appearance. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: BMS-599626 was generally well tolerated, with disease stabilization across a range of tumor types and doses. (Source: Annals of Oncology)

Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion

AJP: Gastrointestinal and Liver Physiology — Tue, 24 Jan 2012 05:00:00 +0100

The gastrointestinal (GI) tract is one of the most susceptible organs to ischemia. We previously reported altered gastric motility after gastric ischemia and reperfusion (I/R). However, there have also been few reports of alterations in the eating behavior after gastric I/R. Ghrelin is a GI peptide that stimulates food intake and GI motility. Although ghrelin itself has been demonstrated to attenuate the mucosal injuries induced by gastric I/R, the endogenous ghrelin dynamics after I/R has not yet been elucidated. The present study was designed to investigate the relationship between food intake and the ghrelin dynamics after gastric I/R. Wistar rats were exposed to 80-min gastric ischemia, followed by 12-h or 48-h reperfusion. The food intake, plasma ghrelin levels, gastric preproghrelin ...

Is attention to detail a similarly strong candidate endophenotype for anorexia nervosa and bulimia nervosa?

The World Journal of Biological Psychiatry — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions. Attention to detail is a stronger candidate endophenotype of AN compared to BN, where poor global integration may be more relevant. The unique contribution of both aspects of weak coherence (superior attention to detail/poor global integration) requires further exploration and understanding in both eating disorders. Integrating cognitive remediation of these traits into treatment for the subset of patients it is relevant for may improve outcome. PMID: 22263673 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)

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ACUTE center for eating disorders

Journal of Hospital Medicine — Mon, 23 Jan 2012 05:00:00 +0100

DISCUSSION:Patients with this degree of severe malnutrition due to eating disorders are medically complex and relatively uncommon. Regionalized subspecialty centers of excellence, in which a multidisciplinary team is led by practitioners of hospital medicine who have developed expertise in a rare condition, may improve clinical outcomes, optimize healthcare resources, and provide unique professional and academic opportunities for the clinicians involved. Journal of Hospital Medicine 2012;. © 2012 Society of Hospital Medicine (Source: Journal of Hospital Medicine)

Accuracy of self‐reported energy intake in weight‐restored patients with anorexia nervosa compared with obese and normal weight individuals

International Journal of Eating Disorders — Mon, 23 Jan 2012 05:00:00 +0100

Discussion:Self‐reported intake should be cautiously interpreted in AN and OB. Future studies are warranted to determine if over‐reporting is related to poor outcome and relapse in AN, or under‐reporting interferes with weight loss efforts in OB. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

Borderline Personality: The Promiscuous Diagnosis

Psychology Today Personality Center — Sun, 22 Jan 2012 17:32:45 +0100

Promiscuous Borderline Personality hangs out with many other diagnoses.read more (Source: Psychology Today Personality Center)

Anorexia Nervosa

About.com Eating Disorders — Sun, 22 Jan 2012 05:00:00 +0100

a serious, life-threatening eating disorder characterized by severe weight loss and self-starvation (Source: About.com Eating Disorders)

School health lessons 'made our son anorexic after it made him paranoid about junk food'

the Mail online | Health — Thu, 19 Jan 2012 13:09:51 +0100

Mr and Mrs Fieldsend, from Hull, East Yorkshire, claim that James's problem started when he was seven, after he was taught about healthy eating at school. (Source: the Mail online | Health)

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Reframing eating during chemotherapy in cancer patients with chemosensory alterations.

European Journal of Oncology Nursing — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSION: To date, interventions to promote eating among cancer patients have focused extensively on symptom management and on recommendations for macro/micronutrient intake. This study underscores the importance of understanding beliefs about eating. These beliefs may help clinicians develop patient-centered nutritional interventions. PMID: 22265664 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)

Foreword

Current Problems in Pediatric and Adolescent Health Care — Wed, 18 Jan 2012 06:37:14 +0100

These days, much of the dialogue surrounding disordered eating behaviors has focused on the childhood obesity epidemic. This month's issue of Current Problems in Pediatric and Adolescent Health Care focuses on those disorders of eating that are associated with undernutrition and weight loss and reminds us that these disorders continue to present tremendous challenges to pediatricians, patients, families, and our society. In this highly evidence-based review, Dr. Ellen Rome discusses the challenges in defining these often puzzling disorders and reviews their changing epidemiology. She shares her extensive clinical experience in diagnosing and treating anorexia nervosa, bulimia, and their variants and provides the reader with practical and nuanced recommendations for thorough history-taking ...

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors [Phase I and Clinical Pharmacology]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion This study demonstrates feasibility and proof-of-concept of class I PI3K inhibition in patients with advanced cancers. BKM120, at the MTD of 100 mg/d, is safe and well tolerated, with a favorable PK profile, clear evidence of target inhibition, and preliminary antitumor activity. (Source: Journal of Clinical Oncology)

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women.

The Journal of Clinical Endocrinology and Metabolism — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion:Young women with AN have low cold-activated BAT, which may be due to impaired BAT thermogenesis. Young women with BAT have higher BMD and lower Pref-1 compared with women without BAT, suggesting that BAT may be involved in the regulation of stem cell differentiation into the bone lineage at the expense of adipogenesis. PMID: 22259053 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Dysphagia in severe anorexia nervosa: A case report

International Journal of Eating Disorders — Tue, 17 Jan 2012 05:00:00 +0100

We describe a patient with severe anorexia nervosa who manifested symptoms of dysphagia, with resultant aspiration pneumonia, at the time of her admission for medical stabilization.Results:The speech pathology team administered dysphagia therapy, using neuromuscular electrical stimulation (NMES) in conjunction with swallowing therapy. Following the course of dysphagia treatment intervention, the patient was able to tolerate an oral diet with improved swallowing function and no ongoing aspiration.Discussion:Patients with severe anorexia nervosa should be screened for possible dysphagia. NMES in the treatment of dysphagia in patients with anorexia nervosa may reduce the need for enteral feeds and prolonged hospitalization. © 2012 by Wiley Periodicals, Inc. Int J Eat Disord 2012. (Source: In...

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Symptoms of Anorexia Nervosa

About.com Eating Disorders — Mon, 16 Jan 2012 05:00:00 +0100

Physical, behavioral and emotional symptoms and warning signs for anorexia nervosa. (Source: About.com Eating Disorders)

The SCOFF Questionnaire

About.com Eating Disorders — Mon, 16 Jan 2012 05:00:00 +0100

is a simple and accurate screening tool for anorexia nervosa and bulimia nervosa. (Source: About.com Eating Disorders)

An

About.com Eating Disorders — Mon, 16 Jan 2012 05:00:00 +0100

an acronym commonly used for anorexia nervosa (Source: About.com Eating Disorders)

[World Report] Pro-anorexia websites pose public health challenge

LANCET — Sat, 14 Jan 2012 05:00:00 +0100

In recent years, websites that promote anorexia and advise people on how to maintain the disorder have appeared on the web. Mario Christodoulou examines the health risks of such sites. (Source: LANCET)

Effects of Feiji Decoction for Soothing the Liver Combined with Psychotherapy  on Quality of Life in Primary Lung Cancer Patients

Chinese Journal of Lung Cancer — Fri, 13 Jan 2012 13:20:50 +0100

Conclusion Feiji Decoction for soothing the liver combined with psychotherapy can alleviate the clinical symptoms, elevate the physical status, and improve the QOL of patients with primary lung cancer. Thus, this therapy has a good clinical therapeutic effect. DOI: 10.3779/j.issn.1009-3419.2012.01.06 (Source: Chinese Journal of Lung Cancer)

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“Photo-Therapy:” A Promising Intervention in Anorexia Nervosa?”

Psychiatric Times — Thu, 12 Jan 2012 13:30:02 +0100

We now communicate in ways that are very different from those available just a decade ago. The iPhone, iPad, and similar devices also enable us to observe ourselves as we perform any number of activities. These and other new devices may have an application their designers never considered. (Source: Psychiatric Times)

Phase I trial of oral S-1 combined with gemcitabine and cisplatin for advanced biliary tract cancer (KHBO1002)

Cancer Chemotherapy and Pharmacology — Wed, 11 Jan 2012 17:51:05 +0100

Conclusions We determined the RD of gemcitabine/cisplatin/S-1 combination therapy for advanced biliary tract cancer; we are proceeding to a phase II study to investigate the efficacy of this combination therapy for advanced biliary tract cancer. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00280-011-1818-2Authors Masashi Kanai, Outpatient Oncology Unit, Kyoto University Hospital, Kyoto, JapanEtsuro Hatano, Department of Surgery, Graduate School of Medicine, Kyoto University Hospital, Kyoto, JapanSyogo Kobayashi, Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, JapanYutaka Fujiwara, Department of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, JapanDaisuke Sakai, Department o...

“Photo-Therapy:” A Promising Intervention in Anorexia Nervosa?

Psychiatric Times — Wed, 11 Jan 2012 12:00:00 +0100

Integrative role of neuropeptides and cytokines in cancer anorexia-cachexia syndrome.

International Journal of Clinical Chemistry — Wed, 11 Jan 2012 05:00:00 +0100

CONCLUSION: There is a need to understand and explore the role of various neuropeptides and cytokines in the pathophysiology of cancer-anorexia syndrome so that therapeutic measures may be designed for effective palliative care. PMID: 22251421 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

International Journal of Clinical Oncology — Tue, 10 Jan 2012 16:57:37 +0100

Conclusions Vorinostat 300 mg bid for 3 consecutive days followed by 4 days of rest was better tolerated in patients with GI cancer than a higher once daily dose. Additionally, there were patients in both groups who achieved stable disease, most maintaining it for longer than 8 weeks, suggesting vorinostat as a possible active agent in the treatment of GI cancer. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s10147-011-0348-6Authors Toshihiko Doi, National Cancer Center Hospital East, Chiba, JapanTetsuya Hamaguchi, National Cancer Center, Tokyo, JapanKuniaki Shirao, Oita University, Oita, JapanKensho Chin, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanKiyohiko Hatake, Cancer Institute Hos...

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Getting Your Eating Back on Track With a Food Plan

Psychology Today Food and Diet Center — Tue, 10 Jan 2012 03:32:27 +0100

Our guide to getting the most out of a food plan to normalize eating read more (Source: Psychology Today Food and Diet Center)

Letters: Anorexia Treatment (1 Letter)

NYT Health — Mon, 09 Jan 2012 23:45:09 +0100

A letter to the editor. (Source: NYT Health)

Anti-epidermal growth factor receptor therapy for advanced head and neck squamous cell carcinoma: a meta-analysis

European Journal of Clinical Pharmacology — Mon, 09 Jan 2012 19:39:45 +0100

Conclusions Anti-EGFR Mabs are effective for both LA and RM HNSCC. In contrast, TKIs were unsuitable for treatment of advanced HNSCC. During anti-EGFR therapy, rash and some gastrointestinal reactions, such as diarrhea and anorexia, should be carefully monitored. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-011-1194-1Authors Shoude Zhang, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000 People’s Republic of ChinaJia Chen, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000 People’s Republic of ChinaHua Jiang, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, ...

Mucinous Adenocarcinoma of Stomach

Diagnostic Imaging — Mon, 09 Jan 2012 12:00:00 +0100

Clinical History: An 84-year-old male patient, known case of HTN and dyslipidemia, complaining of dysphasia for three months. Anorexia and vomiting. Diagnosed as esophageal adenocarcinoma outside for evaluation. (Source: Diagnostic Imaging)

[Original Articles] Selective Attention of Patients With Anorexia Nervosa While Looking at Pictures of Their Own Body and the Bodies of Others: An Exploratory Study

Psychosomatic Medicine — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions The results confirm the assumption of cognitive biases. The differences, however, are often small and vary greatly. (Source: Psychosomatic Medicine)

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Internalizing and Externalizing Behaviour Problems in Childhood Contribute to the Development of Anorexia and Bulimia Nervosa-A Study Comparing Sister Pairs. - Adambegan M, Wagner G, Nader IW, Fernández-Aranda F, Treasure J, Karwautz A.

SafetyLit: All (Unduplicated) — Fri, 06 Jan 2012 15:21:09 +0100

OBJECTIVE: We wanted to clarify whether there is any clinically relevant behavioural psychopathology in patients before onset of an eating disorder (ED) compared with their healthy sisters and if there are differences in behavioural problems between the ED... (Source: SafetyLit: All (Unduplicated))

Experts Urge BMI Method For Calculating Weight In Kids With Eating Disorders

Health News from Medical News Today — Fri, 06 Jan 2012 08:00:00 +0100

An exact determination of expected body weight for adolescents based on age, height and gender is critical for diagnosis and management of eating disorders such as anorexia nervosa and bulimia. However, there are no clear guidelines regarding the appropriate method for calculating this weight in children with such disorders. In a study published online Jan... (Source: Health News from Medical News Today)

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

World Journal of Surgical Oncology — Thu, 05 Jan 2012 05:00:00 +0100

Conclusions: Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment. (Source: World Journal of Surgical Oncology)

Questioning the nutritional management of anorexia patients

Health Facts and Fears — Wed, 04 Jan 2012 05:00:00 +0100

Even though our understanding and awareness of anorexia has improved, it’s still not clear how best to treat anorexic patients when they arrive at the hospital. (Source: Health Facts and Fears)

[To Start Eating again Could Be Dangerous].

Praxis — Wed, 04 Jan 2012 05:00:00 +0100

Authors: Weibel M, Ossola N Abstract A 36-year-old woman with anorexia nervosa and resulting malnutrition decided to change her life and eat properly. One day after the refeeding start, instead of feeling better she felt much worse: fatigue, nausea and leg swelling occurred. She consulted our emergency department. A «refeeding syndrome» has been diagnosed. In this case report we discuss causes, clinical presentation and treatment of this illness. The aim is to make practitians aware about the existing of this disease even with oral refeeding. Warning signs have to be interpreted correctly in order to avoid dramatic consequences. PMID: 22219076 [PubMed - in process] (Source: Praxis)

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Pregnancy saved my life: Recovering anorexic reveals how desire for baby helped her defeat food demons

the Mail online | Health — Tue, 03 Jan 2012 11:33:11 +0100

Catherine Thomson, 27, from Derby, told how becoming pregnant has helped to save her life after years of suffering from a debilitating eating disorder. (Source: the Mail online | Health)

Low incidence of positive smooth muscle antibody and high incidence of isolated IgM elevation in Chinese patients with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome: a retrospective study

BMC Gastroenterology — Tue, 03 Jan 2012 05:00:00 +0100

Conclusions: Overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis was not rare in Chinese patients with clinical manifests of autoimmune liver diseases. Overlap of the diseases should not be disregarded when isolated IgM elevation was exhibited, and smooth muscle antibody might have little diagnostic significance in the overlap syndrome. If it was difficult to make a definite diagnosis, liver biopsy was necessary. (Source: BMC Gastroenterology)

Hospital Treatment for Anorexia Is Questioned

NYT Health — Mon, 02 Jan 2012 21:54:17 +0100

A study has found that the protocol of meting out meals with caution to people hospitalized with anorexia does not work. (Source: NYT Health)

Anorexic Patients Can Be Fed More Aggressively, Study Says

NYT Health — Mon, 02 Jan 2012 21:16:47 +0100

A study has found that the protocol of meting out meals with caution to people hospitalized with anorexia does not work. (Source: NYT Health)

Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

Neuroradiology — Mon, 02 Jan 2012 06:58:11 +0100

Conclusions Significant changes in GM metabolite concentrations were observed in AN possibly triggered by elevated excitotoxin Glu. Increased tCho may indicate modifications of membrane phospholipids due to increased catabolism in the parietal region. Since no significant changes in phosphorylated choline compounds were found for the frontal region, the tCho increase in this region may hint to fluidity changes. Content Type Journal ArticleCategory Paediatric NeuroradiologyPages 1-12DOI 10.1007/s00234-011-1001-9Authors Stella Blasel, Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, GermanyUlrich Pilatus, Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, GermanyJoerg Magerkurth, Institut...

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Cognitive-behavioral treatment of body image disturbance in a congenitally blind patient with anorexia nervosa.

The American Journal of Psychiatry — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Thomas JJ, Weigel TJ, Lawton RK, Levendusky PG, Becker AE PMID: 22223010 [PubMed - in process] (Source: The American Journal of Psychiatry)

Abdominal Migraine in Children: Is It All in Their Heads?

The Journal for Nurse Practitioners — Sun, 01 Jan 2012 05:00:00 +0100

Abstract: Abdominal migraine in children is a migraine variant, described as isolated, paroxysmal attacks of severe periumbilical abdominal pain associated with nausea, vomiting, pallor, anorexia, headache, and photophobia, with intervening periods of normality. Abdominal migraine is a diagnosis of exclusion, as presenting symptomatology can also be characteristic of other disease processes. An extensive history and physical examination are necessary to differentiate between abdominal migraine and acute abdominal pain. Limited studies have been conducted on the management of children with an acute abdominal migraine attack. Treatment and prophylaxis of acute attacks is essential to reduce recurrence, severity, and extent of pain. (Source: The Journal for Nurse Practitioners)

Shared Written Case Formulations and Weight Change in Outpatient Therapy for Anorexia Nervosa: A Naturalistic Single Case Series

Clinical Psychology — Sun, 01 Jan 2012 05:00:00 +0100

This study explored the relationship between (a) the delivery (b) the quality of a shared written case formulation and weight in outpatient psychological therapy for anorexia nervosa.A naturalistic single case series approach was used to examine the case notes of women who had attended a specialist eating disorders service over a 2‐year period. The case notes of 15 adult women who had undergone outpatient psychological therapy for anorexia nervosa with a shared written case formulation component were reviewed. The impact of the quality of the case formulation on weekly weight was examined for 14 of the clients where the case formulation was available. The nature of the relationship between the delivery of the written shared case formulation and weight was examined for all 15 clients.Ther...

Emotional Processing Following Recovery from Anorexia Nervosa

European Eating Disorders Review — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionsThis study demonstrates functional levels of emotional processing following recovery from AN. It substantiates models proposing that maladaptive beliefs about emotions link to emotional avoidance and supports inclusion of these factors as treatment foci. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association. (Source: European Eating Disorders Review)

Knowledge and Attitudes of Psychiatrists Towards Eating Disorders

European Eating Disorders Review — Sun, 01 Jan 2012 05:00:00 +0100

This study examined the eating disorder mental health literacy of psychiatrists.MethodA sample of psychiatrists completed a questionnaire measuring knowledge of and attitudes towards eating disorders. Knowledge questions were based on the academic literature, standard diagnostic criteria and national guidelines on the management of eating disorders. Attitude items covered beliefs about the aetiology and treatment of eating disorders, confidence levels in diagnosis and management and the use of compulsory measures in anorexia nervosa.ResultsPsychiatrists' knowledge of eating disorders was variable with specific gaps in both diagnosis and management. Psychiatrists felt more confident in diagnosing eating disorders than managing these conditions. Attitudes towards eating disorders were less s...

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Actinomyces turicensis infection mimicking ovarian tumour.

Singapore Medical Journal — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Ong C, Barnes S, Senanayake S Abstract This case report explores an unusual presentation of a commensal organism, Actinomyces, which mimicked a presentation of ovarian cancer. A 73-year-old woman presented to a tertiary level hospital with persistent left iliac fossa abdominal pain, anorexia and fever lasting over one week, with a three-month history of bright rectal bleeding. Imaging was suggestive of malignancy. Fine needle aspiration of an enlarged lymph node was non-diagnostic. Blood cultures taken at presentation became positive after two days for Gram-positive rods, which were most likely Actinomyces. The patient was treated with penicillin 1.8 g four hourly with rapid improvement. Actinomycosis is frequently misdiagnosed as malignancy initially due to its relatively...

Bioimpedance and Bioimpedance Vector Analysis in patients with Anorexia Nervosa

European Eating Disorders Review — Sun, 01 Jan 2012 05:00:00 +0100

ConclusionConventional BIA has little utility in these patients. However, BIVA could be a suitable alternative in the medical management reflecting ECW volume changes and later genuine tissue mass increases. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association. (Source: European Eating Disorders Review)

The need for complex ideas in anorexia nervosa: Why biology, environment, and psyche all matter, why therapists make mistakes, and why clinical benchmarks are needed for managing weight correction

International Journal of Eating Disorders — Sun, 01 Jan 2012 05:00:00 +0100

Cost‐of‐illness studies and cost‐effectiveness analyses in eating disorders: A systematic review

International Journal of Eating Disorders — Sun, 01 Jan 2012 05:00:00 +0100

Discussion:The number of publications investigating costs in EDs has increased recently. However, no COI provided a comprehensive estimate of costs, and the comparability of CEA was limited. Nonetheless, the results indicate that the costs arising from EDs are substantial. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) (Source: International Journal of Eating Disorders)

Novel Δ9‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects

British Journal of Clinical Pharmacology — Sat, 31 Dec 2011 07:42:24 +0100

Conclusions Oral Namisol® showed promising PK and PD characteristics. Variability and Tmax of THC plasma concentrations were smaller for Namisol® than reported for studies using oral dronabinol and nabilone. This study was performed in a limited number of healthy volunteers. Therefore, future research on Namisol® should study clinical effects in patient populations. (Source: British Journal of Clinical Pharmacology)

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Children suffering from anorexia at three

the Mail online | Health — Sat, 31 Dec 2011 03:11:21 +0100

Hundreds of youngsters are being treated in hospital for anorexia and bulimia every year thanks to the pressures to conform to certain types of body image. (Source: the Mail online | Health)

How Much Calorie Restriction Is Enough to Slow Brain Aging?

Psychology Today Food and Diet Center — Fri, 30 Dec 2011 15:35:23 +0100

Unless you plan on becoming a long distance runner, or something similar, exercising is never going to be as beneficial to your brain and body as restricting the number of calories you consume! Primary Topic: Diet read more (Source: Psychology Today Food and Diet Center)

Theory of mind in bulimia nervosa

International Journal of Eating Disorders — Fri, 30 Dec 2011 07:25:20 +0100

This study aimed to investigate theory of mind (ToM) in individuals with bulimia nervosa (BN), an area neglected by empirical research despite social functioning difficulties in this disorder and evidence of ToM deficits in people with anorexia nervosa (AN).Method:ToM was assessed in 48 BN and 34 Eating Disorder Not Otherwise Specified BN‐type (EDNOS‐BN) outpatients and 57 healthy controls (HCs) using the Reading the Mind in the Eyes and the Reading the Mind in the Films (RMF), an ecologically valid task novel to BN research.Results:Overall performance in BN and EDNOS‐BN groups was equivalent to HCs on both tasks. Individuals with BN had enhanced negative emotion recognition on the RMF.Discussion:Individuals with AN and BN have distinct socio‐cognitive profiles. Further research in...

Watching Eating Disorders on TV: How Does This Help?

Psychology Today Food and Diet Center — Thu, 29 Dec 2011 20:23:03 +0100

Last month Lifetime premiered a show about eating disorders, hosted and produced by Tracey Gold. The actress famous from the hit sitcom Growing Pains nearly died from anorexia. In each one-hour episode of Starving Secrets, Gold, she works with women in the grips of anorexia or bulimia. Is this a good idea? Primary Topic: Eating Disorders read more (Source: Psychology Today Food and Diet Center)

Guess Who's Coming to Dinner: Eating Disorders in African Americans

Psychology Today Food and Diet Center — Thu, 29 Dec 2011 17:59:39 +0100

Little was known about disordered eating in Black people until recently. Although anorexia nervosa is much less common, African Americans struggle with eating issues too. Primary Topic: Eating Disorders read more (Source: Psychology Today Food and Diet Center)

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Endoscopic Diagnosis in Ascaris lumbricoides Case with Pyloric Obstruction.

Turkish Society for Parasitology — Thu, 29 Dec 2011 10:36:02 +0100

Authors: Peker K, Kılıç K Abstract Ascaris lumbricoides is the largest and most prevalent helminth seen in the human body. Ascariasis having high morbidity and mortality causes a unique type of intestinal obstruction with specific problems. This is probably due to reduced intestinal absorption and luminal obstruction, which can lead to anorexia and blockage of the absorbing surface. It affects humans especially in developing countries. This essay presented a 78- year- old female case had severe abdominal pain, nausea and constipation for seven days and the pylorus was obstructed by A. lumbricoides and diagnosis was obtained by endoscopy. During endoscopy in the treatment, the ascariasis that could be removed was. Afterwards, 100mg mebendazole was given for 3 da...

Looking Back on a Year of Eating Disorders News

Psychology Today Parenting Center — Thu, 29 Dec 2011 01:21:31 +0100

They seem to be increasing in numbers, yet we know more about eating disorders and how to diagnose and treat them than ever before Primary Topic: Eating Disorders read more (Source: Psychology Today Parenting Center)

RANKL/RANK/OPG system and bone status in females with anorexia nervosa

Bone — Wed, 28 Dec 2011 20:53:30 +0100

In conclusion, the body mass, BMI values, and bone markers suppression observed in female patients with AN might be associated with an increase in OPG and sRANKL levels and a significant decrease of the OPG/sRANKL ratio. Although higher OPG levels may compensate for excessive bone resorption in female patients with AN, the lower OPG/sRANKL ratio seems to indicate that some inadequacies exist regarding this compensation effect, which might contribute to low bone density in these patients. The OPG/sRANKL ratio might prove a more relevant marker to predict bone metabolism in female patients with AN than sRANKL and/or OPG alone. (Source: Bone)

Adolescent female rats exhibiting activity‐based anorexia express elevated levels of GABAA receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines

Synapse — Wed, 28 Dec 2011 05:00:00 +0100

AbstractActivity‐based anorexia (ABA) is an animal model for anorexia nervosa that has revealed genetic links to anxiety traits and neurochemical characteristics within the hypothalamus. However, few studies have used this animal model to investigate the biological basis for vulnerability of pubertal and adolescent females to ABA, even though the great majority of the anorexia nervosa cases are females exhibiting the first symptoms during puberty. GABAergic inhibition of the hippocampus strongly regulates anxiety as well as plasticity throughout life. We recently showed that the hippocampal CA1 of female mice undergo a dramatic change at puberty onset – from expressing virtually none of the non‐synaptic α4βδ GABAA receptors (GABARs) pre‐pubertally to expressing these GABARs at a...

Intact sensory function in anorexia nervosa.

Am J Clin Nutr — Wed, 28 Dec 2011 05:00:00 +0100

CONCLUSIONS: There is no systematic sensory-perceptual deficit in AN patients, and specifically, not in gustatory function. The few differences shown might be due to fear of food-related stimuli or comorbidity. PMID: 22205316 [PubMed - as supplied by publisher] (Source: Am J Clin Nutr)

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[Asthma as a psychosomatic disease. The causes, scale of the problem, connection with alexithymia and asthma control.]

Pneumonologia i Alergologia Polska — Mon, 26 Dec 2011 23:31:28 +0100

Conclusion: The high level of alexithymia among the patients with asthma, frequent coincidence of asthma and psychosomatic diseases and the distinct influence of stress and strong emotions on causing asthma exacerbations, proven in this study, confirm that asthma may be considered as the psychosomatic disease. Pneumonol. Alergol. Pol. 2012; 80, 1: 13-19. PMID: 22187176 [PubMed - as supplied by publisher] (Source: Pneumonologia i Alergologia Polska)

DSM‐IV versus DSM‐5: Implementation of proposed DSM‐5 criteria in a large naturalistic database

International Journal of Eating Disorders — Fri, 23 Dec 2011 23:52:51 +0100

Discussion:Remaining problems with the proposed changes were also highlighted, and possible further refinement is discussed. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2011) (Source: International Journal of Eating Disorders)

Diagnosing underweight in adolescent girls: Should we rely on self-reported height and weight?

Eating Behaviors — Fri, 23 Dec 2011 22:08:55 +0100

This study examines the reliability of self-reported height, weight and weight change in underweight versus normal weight adolescent females. Self-reported height and weight were obtained from 162 schoolgirls without an eating disorder (12-16years), and compared to objective measurements afterwards. Weight change was assessed 4months later. The influence of age and current BMI on the reliability of self-reports was analyzed by linear regression analyses. With increasing age, height and BMI were reported more accurately. With increasing BMI, the underestimation of weight increased. Underweight girls overestimated their weight significantly compared to normal weight girls. Only 41% of the girls with a weight loss (>1kg) in the past 4months reported this accurately. Therefore, especially i...

The Eating Disorder Inventory-2 Perfectionism scale: Factor structure and associations with dietary restraint and weight and shape concern in eating disorders.

Eating Behaviors — Fri, 23 Dec 2011 22:07:34 +0100

This study aimed to investigate the factor structure of the EDI-P in a transdiagnostic sample of females seeking treatment for an eating disorder, and to determine the unique association between EDI-P dimensions, weight and shape concern, and dietary restraint in anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified. Two hundred and ninety nine females seeking treatment for an eating disorder at an outpatient eating disorder service completed the Eating Disorder Examination and the EDI-P. Confirmatory factor analysis supported a two-factor model of the EDI-P comprising self-oriented and socially prescribed perfectionism. Self-oriented perfectionism, but not socially prescribed perfectionism, accounted for unique variance in weight and shape concern and di...

A retrospective look at the internal help-seeking process in young women with eating disorders.

Eating Disorders — Fri, 23 Dec 2011 20:37:32 +0100

Authors: Schoen EG, Lee S, Skow C, Greenberg ST, Bell AS, Wiese JE, Martens JK Abstract This qualitative study retrospectively explored the help-seeking process in women with eating disorders. Interviews were conducted with 14 college-age women suffering from anorexia nervosa, bulimia nervosa, or eating disorder NOS. Grounded theory was utilized to develop a preliminary model of the help-seeking process. Participants described a gradual shift from denial to increased awareness of self and the impact of the illness. This core process was transient in nature and influenced by interpersonal feedback, critical incidents, the women's general attitude toward help- seeking, and prior treatment experiences. Implications for clinicians include an increased focus on the transient awareness o...

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Self-forgiveness in anorexia nervosa and bulimia nervosa.

Eating Disorders — Fri, 23 Dec 2011 20:37:22 +0100

This study investigated whether low levels of self-forgiveness were associated with eating disorder symptomatology. Participating women (N = 51) had diagnoses of anorexia nervosa, bulimia nervosa, or no eating disorder diagnosis. They completed 3 measures of self-forgiveness. Women with eating disorders had lower levels of self-forgiveness compared with control participants. Results suggest that incorporating self-forgiveness interventions into current eating disorder treatments should be evaluated in future research as they might enhance clinical outcomes. PMID: 22188058 [PubMed - in process] (Source: Eating Disorders)

A novel adult case of juvenile-onset Alexander disease: complete remission of neurological symptoms for over 12 years, despite insidiously progressive cervicomedullary atrophy

Neurological Sciences — Fri, 23 Dec 2011 16:51:22 +0100

We present here a 25-year-old woman with genetically confirmed (p.R276L mutation in the GFAP gene) juvenile-onset AxD. Episodic vomiting appeared at age nine, causing anorexia and insufficient growth. Brain MRI at age 11 showed a small nodular lesion with contrast enhancement in the left dorsal portion of the cervicomedullary junction. Her episodic vomiting improved spontaneously at age 13, and she became neurologically asymptomatic. The enhancement of the lesion disappeared simultaneously, although the plaque remained. Longitudinal MRI observations, however, revealed insidiously progressive cervicomedullary atrophy without a signal change. This case broadens our knowledge of AxD: (1) molecular analysis of the GFAP gene is warranted in patients with MRI evidence of tumor-like lesions ...

An Extremely Unusual and Large Cause of Anemia

Gastroenterology — Thu, 22 Dec 2011 05:00:00 +0100

Question: A 63-year-old man with a long-standing medical history of anemia presented to the gastroenterology outpatient clinic with diffuse abdominal pain, progressive dragging sensation in the left upper quadrant, and marked dizziness. Other prominent clinical symptoms included a weight loss of 15 lbs over 2 months, anorexia, and intermittent constipation. Clinical examination revealed tenderness in the left upper quadrant and massive splenomegaly. On further palpation, the spleen extended to the umbilicus, and had a smooth surface and a very firm consistency. The patient was hemodynamically stable with an arterial blood pressure of 111/56 mmHg and a heart rate of 90 beats/min. A complete blood cell count showed anemia (hemoglobin, 5.7 g/dL) and a normal platelet count. No abnormalities w...

The Genetics of Anorexia Nervosa.

Clinical Pharmacology and Therapeutics — Wed, 21 Dec 2011 05:00:00 +0100

Authors: Clarke TK, Weiss AR, Berrettini WH Abstract Anorexia nervosa (AN) is a disease defined by inappropriate weight loss and maintenance of body weight <85% of that expected for weight and height; it is most common in adolescent women aged 15-19 years. Numerous studies have highlighted the familial aggregation of the disease, suggesting a significant genetic component to its etiology. The purpose of this review is to discuss the different fields of genetic research-both in humans and animals-that have contributed to the understanding of this complex disorder. Candidate gene studies focusing on genes involved in the hypothalamic control of appetite and energy regulation have found genetic risk variants that increase risk for AN. A recent genome-wide association study has high...

Emphysematous Changes of the Liver

Gastroenterology — Wed, 21 Dec 2011 05:00:00 +0100

Question: A 59-year-old woman presented to the emergency department with nausea and epigastric pain for 2 days preceded by 2 weeks of anorexia. Several years ago, she was diagnosed as glucose intolerant, but did not receive regular follow-up. On examination, her temperature was 34.8°C and her blood pressure was 81/53 mm Hg. She had icteric sclera, palpated tenderness in the upper right quadrant of the abdomen, and hepatomegaly (liver span of 14 cm at the midclavicular line). Blood tests showed a leukocyte count of 5700/mm3, (55% neutrophils; 19% lymphocytes), a glucose level of 347 mg/100 mL, an aspartate aminotransferase of 10,920 U/L, an alanine aminotransferase level of 3651 U/L, a total bilirubin of 4.8 mg/dL, and a creatinine level of 3.4 mg/100 mL. Plain film of the chest was normal...

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Refeeding Hospitalized Adolescents With Anorexia Nervosa: Is “Start Low, Advance Slow” Urban Legend or Evidence Based?

Journal of Adolescent Health — Tue, 20 Dec 2011 18:43:29 +0100

See Related Article p. 24 (Source: Journal of Adolescent Health)

A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a

Annals of Oncology — Tue, 20 Dec 2011 05:00:00 +0100

Conclusions: Patupilone at 8 mg/m2 was tolerable, had antitumor activity, and was associated with symptomatic improvement in patients previously treated with docetaxel. (Source: Annals of Oncology)

Cannabinoid hyperemesis

Emergency Medicine Journal — Tue, 20 Dec 2011 05:00:00 +0100

A 21-year-old woman presented with a 4-week history of sudden onset vomiting, nausea and anorexia. Questioning revealed that she had a 7-year history of heavy cannabis use (smoking). She did not describe abdominal pain, change in bowel habit, antibiotic use, foreign travel or contact with gastroenteritis. Biochemistry results demonstrated mild metabolic derangement with a low potassium and a low bicarbonate, and urine toxicology was positive for cannabinoids. Other investigations, including a full blood count, renal function tests, liver function tests, a coagulation sample, an ECG, urinary β-hCG and a CT head scan, were all normal. A diagnosis of cannabinoid hyperemesis was made and her symptoms resolved after treatment with intravenous fluids, antiemetics and abstinence from cannabi...

A 76-year-old man with progressive lower back pain and right thigh swelling

Emergency Medicine Journal — Tue, 20 Dec 2011 05:00:00 +0100

A 76-year-old man with no medical history presented with progressive lower back pain and right thigh swelling which he had had for 5 days. Fever, limp and anorexia were also noted. Lower back pain was brought on by extension of the right hip and physical examination showed right thigh swelling, erythema and skin crepitus. Blood examination disclosed generalised inflammation with a high C-reactive protein level. CT showed dilatation of right psoas muscle with fluid accumulation and gas formation (figure 1A), which extended to the right iliac muscle and the intermuscular bundles in the right thigh (figure 1B). An iliopsoas abscess complicated with necrotising fasciitis was considered. He was then admitted to the intensive care unit, where he received surgical intervention and antibiotic...

Diminished size-weight illusion in anorexia nervosa: evidence for visuo-proprioceptive integration deficit.

Experimental Brain Research — Tue, 20 Dec 2011 05:00:00 +0100

Authors: Case LK, Wilson RC, Ramachandran VS Abstract Individuals with anorexia nervosa (AN) experience pronounced body image distortion in combination with a pernicious desire to maintain a dangerously low body weight. Relatively little is known, however, about the mechanism underlying body image distortion in AN. Despite having normal visual perception, individuals with AN both feel and see themselves as large-bodied and show deficits in interoception and haptic perception, suggesting a potential deficit in visual and tactile integration. The size-weight illusion (SWI) arises when two objects of equal weight but different sizes are held. Typical individuals experience a strong and robust illusion that the smaller object feels much heavier than the larger object because of an impl...

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The sociocommunicative deficit subgroup in anorexia nervosa: autism spectrum disorders and neurocognition in a community-based, longitudinal study.

Psychological Medicine — Tue, 20 Dec 2011 05:00:00 +0100

CONCLUSIONS: A subgroup of subjects with AN meet criteria for ASDs. They may represent the extreme of neurocognitive and personality problems to be found more generally in AN. PMID: 22186945 [PubMed - as supplied by publisher] (Source: Psychological Medicine)

Teens With Anorexia May Need Aggressive Feeding ProtocolTeens With Anorexia May Need Aggressive Feeding Protocol

Medscape Today Headlines — Mon, 19 Dec 2011 22:44:35 +0100

Medscape Medical News (Source: Medscape Today Headlines)

New Educational Documentary Film and Curriculum on Eating Disorders

Psychology Today Food and Diet Center — Mon, 19 Dec 2011 17:09:47 +0100

A new documentary-style educational film and curriculum are now available for free from the non-profit organization NORMAL Primary Topic: Eating Disorders read more (Source: Psychology Today Food and Diet Center)

Olfaction in child and adolescent anorexia nervosa

Journal of Neural Transmission — Mon, 19 Dec 2011 16:51:46 +0100

Abstract Previous studies indicate disturbed olfactory functions in anorexia nervosa with presumable relationship to the clinical symptom of food aversion and weight loss. However, these studies are in part limited due to inadequately matched control samples, insufficient exclusion criteria, complex interactions of the olfactory and trigeminal system, and the lack of regard to co-morbidity and medication. Thus, we investigated olfactory function in 26 female adolescent patients with anorexia nervosa and 23 healthy controls matched for age, gender, handedness, and intelligence. No significant group differences were identified. Controlling for co-morbid disorders, psychopharmacological treatment, and depressivity revealed superior olfactory identification performance in the ...

TAK1 in brain endothelial cells mediates fever and lethargy

The Journal of Experimental Medicine — Mon, 19 Dec 2011 05:00:00 +0100

In conclusion, we demonstrate that TAK1 in brain endothelial cells induces COX-2, most likely by activating p38 MAPK and c-Jun, and is necessary for fever and sickness behavior. (Source: The Journal of Experimental Medicine)

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Aquaporin‐4 autoantibody: a neurogenic cause of anorexia and weight loss

Developmental Medicine and Child Neurology — Sat, 17 Dec 2011 16:48:27 +0100

We describe a 14‐year‐old female with positive aquaporin‐4 antibody whose clinical course was dominated by severe anorexia with associated weight loss (from 68‐41kg; body mass index 25.2–15.6). Magnetic resonance imaging showed lesions in the medulla, pons, and thalami. Although she had asymptomatic radiological longitudinally extensive transverse myelitis, she never had symptoms or signs referable to the spinal cord or the optic nerves. We propose that anorexia and weight loss should be considered part of the NMO spectrum, probably related to area postrema involvement. (Source: Developmental Medicine and Child Neurology)

Phase I Study of Bosutinib, a Src/Abl Tyrosine Kinase Inhibitor, Administered to Patients with Advanced Solid Tumors.

Clinical Cancer Research — Fri, 16 Dec 2011 05:00:00 +0100

CONCLUSIONS: Bosutinib was generally well tolerated in patients with solid tumors, with the main toxicity being gastrointestinal. The RP2D was 400 mg/day orally. Further study of bosutinib is planned in combination regimens. PMID: 22179664 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Summary: International Kidney Cancer Symposium

Kidney Cancer Association — Thu, 15 Dec 2011 16:51:59 +0100

Conclusions: Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR. No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question for this presentation was: is there a future for robotic PN? At Society of Urologic Oncology (SUO) 2007 meeting there ...

Clinical Characteristics of Patients with Remitting Seronegative Symmetrical Synovitis with Pitting Edema Compared to Patients with Pure Polymyalgia Rheumatica.

J Rheumatol — Thu, 15 Dec 2011 05:00:00 +0100

CONCLUSION: Despite evidence that RS3PE is clinically distinct from PMR, we observed characteristics, treatment response, and outcomes like those expected in pure PMR. Compared to patients with pure PMR, patients with RS3PE are more likely to be male, to be depressed, and to smoke. Contrary to earlier studies, no clear association of RS3PE with malignancy was found despite rigorous cancer screening, although clinicians should be aware that patients with concurrent cancer may manifest more systemic signs and symptoms, as well as steroid resistance. PMID: 22174210 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Kate Chilver dies after 16-year anorexia battle in 'worst case' doctors had ever seen

the Mail online | Health — Wed, 14 Dec 2011 17:00:22 +0100

Kate Chilver, 31, from Ealing, west London, weighed less than 66lbs - around 4 stone - and was so thin that parts of her stomach and bowel had ‘died’ through lack of blood supply. (Source: the Mail online | Health)

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Understanding Eating Disorders

Psychology Today Parenting Center — Wed, 14 Dec 2011 16:07:56 +0100

Earlier this year I read a fantastic memoir about one mother's journey, trying to understand anorexia. Brave Girl Eating gives readers a glimpse inside the struggle to beat an eating disorder. I hope you'll gain new perspective after reading my interview with author Harriet Brown. Primary Topic: Eating Disorders read more (Source: Psychology Today Parenting Center)

Clinical Aspects of Dermatitis Associated with Dirofilaria repens in Pets: A Review of 100 Canine and 31 Feline Cases (1990–2010) and a Report of a New Clinic Case Imported from Italy to Dubai

International Journal of Biomedical Imaging — Tue, 13 Dec 2011 21:25:00 +0100

Cutaneous dirofilariasis is a parasitic disease caused by the mosquito-borne filarial nematodes Dirofilaria (Nochtiella) repens, living in the subcutaneous tissue of dogs, cats, wild carnivores, and humans. Cases have been recently reported also from Germany, Czech Republic, Hungary, Ukraine, Russia, Austria, Switzerland, France, The Netherlands, and the Middle East. D. repens is not widely known to cause chronic pruritic dermatitis in animals. Dermatological signs observed in 100 canine clinic cases were pruritus (100%), erythema (79%), papulae (62%), focal or multifocal alopecia (55%), hyperkeratosis (18%), crusting (14%), nodules (12%), acantosis (5%), and eczema (3%). Signs other than dermatological were conjunctivitis (46%), anorexia (35%), ...

Mate Tea (Ilex paraguariensis) Promotes Satiety and Body Weight Lowering in Mice: Involvement of Glucagon-Like Peptide-1.

Biological and Pharmaceutical Bulletin — Tue, 13 Dec 2011 19:42:03 +0100

In this study, to verify the mode of action of mate on FI and consequently on BW, we examined the anorexic effects of mate on the appetite and satiety markers glucagon-like peptide 1 (GLP-1) and leptin in high-fat diet-fed ddY mice. GLP-1 is a peptide signal generated by the gastrointestinal tract, which regulates appetite and influences BW, whereas leptin is an afferent signal from the periphery to the brain in a homeostatic feedback loop that regulates adipose tissue mass, thus leading to decreased appetite and FI and increased energy expenditure. Chronic administration of mate (50, 100 mg/kg) for 3 weeks significantly reduced FI, BW, and ameliorated blood fats, liver fats, and adipose tissue. Mate induced significant increases in GLP-1 levels and leptin levels compared with the control....

Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows

Archives of Virology — Tue, 13 Dec 2011 17:02:27 +0100

Abstract Bovine torovirus (BToV) is recognized as an enteric pathogen of calves, but its etiological role in diarrhea and epidemiological characterization in adult cows remain unclear. In 2007-2008, three outbreaks of epidemic diarrhea occurred in adult cows at three dairy farms in Niigata Prefecture, Japan. BToV was the only enteric pathogen detected in these outbreaks, as determined by electron microscopy, reverse transcription-PCR, bacteria and parasite tests of fecal samples, and antibody tests with paired sera. The epidemiological features of the three outbreaks were similar to those of bovine coronavirus infection, except for the absence of bloody diarrhea, with diarrhea spreading among most adult cows, but not in calves, within several days and diarrhea lasting for ...

Contribution of Nutritional Deficit to the Pathogenesis of the Nonthyroidal Illness Syndrome in Critical Illness: A Rabbit Model Study.

Endocrinology — Tue, 13 Dec 2011 05:00:00 +0100

In conclusion, in this rabbit model of sustained critical illness, reduced circulating T(3), but not T(4), levels could be prevented by parenteral nutrition, which may be mediated by leptin and its actions on tissue deiodinase activity. PMID: 22166982 [PubMed - as supplied by publisher] (Source: Endocrinology)

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Anorexia Recommendations Challenged

Health News from Medical News Today — Mon, 12 Dec 2011 15:00:00 +0100

According to researchers at UCSF, adolescents who are hospitalized with anorexia nervosa do not gain considerable weight during their initial week in hospital by receiving treatment based on current guidelines for refeeding. The study is published in the January issue of the Journal of Adolescent Health with an associated report. The study challenges the current guidelines to feeding adolescents with anorexia nervosa during hospitalization for malnutrition... (Source: Health News from Medical News Today)

[The Prevalence of Eating Disorders (EDs) and Comorbid Psychiatric Disorders in Adolescents: A Two-Stage Community-Based Study].

Turkish Journal of Psychiatry — Mon, 12 Dec 2011 13:54:02 +0100

CONCLUSION: The results of this study show that whereas the point prevalence rate for EDs among all the participants was 2.3%, it was 4.03% among the female participants. Moreover, ED not otherwise specified was the most prevalent ED, and binge eating disorder was the most common ED among the males. The prevalence rates in the present study are similar to those observed in Western countries, except for the prevalence rate for anorexia nervosa, which in the present study was lower. Major depression and generalized anxiety disorder were the most prevalent comorbid disorders in the ED group. PMID: 22143945 [PubMed - in process] (Source: Turkish Journal of Psychiatry)

Restrictive anorexia nervosa: a silent enemy for the eyes and vision

British Journal of Ophthalmology — Mon, 12 Dec 2011 05:00:00 +0100

Anorexia nervosa (AN) is an eating disorder (ED) characterised by the refusal to maintain body weight at or above normal, intense fear of gaining weight, disturbance of body shape perception, and amenorrhoea in women.1 There are two types of AN3: restrictive (reduction in daily energy intake) and binge/purging (binge-eating episodes followed by compensatory behaviour to prevent weight gain: vomiting, drug misuse, excessive physical exercise).2 A recent publication by Moschos et al3 showed a lower foveal and inferior retinal nerve fibre layer (RNFL) thickness and significantly lower dopamine levels in 13 women with AN compared with controls. Multifocal electroretinography showed poorer macular function but no differences in best corrected visual acuity (BCVA) in the women with AN. The autho...

[Experience with levetiracetam in the treatment of childhood refractory epilepsy.]

Archives de Pediatrie — Mon, 12 Dec 2011 05:00:00 +0100

CONCLUSION: This study confirms the effectiveness and tolerance of LEV used as an adjuvant therapy in children presenting drug-resistant epilepsy, particularly in the very young ones. PMID: 22169571 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Solutions to Binge Eating

Psychology Today Food and Diet Center — Mon, 12 Dec 2011 03:44:01 +0100

Most people with eating disorders will engage in binge eating at some time over the course of their disorder whether they suffer from anorexia, bulimia, or binge-eating disorder itself. Binge eating is a distinctive behavioral pattern in which attempts to restrict eating (which may or may not result in actual dietary restriction) are interrupted by repeated episodes of binge eating. Primary Topic: Diet read more (Source: Psychology Today Food and Diet Center)

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Study Challenges Decades-Old Treatment Guidelines For Anorexia

Health News from Medical News Today — Sat, 10 Dec 2011 09:00:00 +0100

Adolescents hospitalized with anorexia nervosa who receive treatment based on current recommendations for refeeding fail to gain significant weight during their first week in the hospital, according to a new study by UCSF researchers. The findings, published in the January issue of the Journal of Adolescent Health with an accompanying editorial, challenge the current conservative approach to feeding adolescents with anorexia nervosa during hospitalization for malnutrition... (Source: Health News from Medical News Today)

The management of diabetes in terminal illness related to cancer

QJM — Sat, 10 Dec 2011 05:00:00 +0100

The management of diabetes during terminal illness is complex, with lack of agreement and consensus among physicians and multidisciplinary teams. Despite the plethora of guidelines available for the management of diabetes, there exists no agreed, evidence-based strategy for managing diabetes during terminal illness and at the end of life. A number of physiological factors may influence glycaemic control during terminal illness. These include anorexia, cachexia, malabsorption, renal and hepatic failure. Furthermore, controversy exists on the frequency of blood glucose monitoring, the optimum blood glucose range and how to achieve this. We review the factors influencing blood glucose during terminal illness and provide a suggested approach to managing patients with type 1 and type 2 diabetes...

Anorexia Nervosa

eMedicineHealth.com — Fri, 09 Dec 2011 07:00:00 +0100

(Source: eMedicineHealth.com)

Functional Recovery of a Patient With Anorexia Nervosa: Physical Intervention in the Acute Hospital Setting.

Physical Therapy — Fri, 09 Dec 2011 05:00:00 +0100

DISCUSSION:/b>Physical therapy as a part of the acute hospital multi-disciplinary plan of care may have benefitted this patient with AN who experienced impaired mobility. This case report highlights key factors in the clinical decision-making process, including physiologic, behavioral, and intervention factors that minimized kilocalorie expenditure. PMID: 22156027 [PubMed - as supplied by publisher] (Source: Physical Therapy)

Intestinal inflammation influences α-MSH reactive autoantibodies: Relevance to food intake and body weight

Psychoneuroendocrinology — Fri, 09 Dec 2011 03:39:07 +0100

Summary: Autoantibodies reacting with alpha-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide, are involved in regulation of feeding. In this work we studied if intestinal inflammation (mucositis) may influence α-MSH autoantibodies production relevant to food intake and body weight. Mucositis and anorexia were produced in Sprague–Dawley rats by methotrexate (MTX, 2.5mg/kg/day, for three days, subcutaneously). Plasma levels of total IgG and of α-MSH autoantibodies were measured during and after MTX-induced mucositis and were compared with pair-fed and ad libitum-fed controls. Effects of intraperitoneal injections of rabbit anti-α-MSH IgG (3 or 10μg/day/rat) on MTX-induced anorexia and on plasma α-MSH peptide concentration were separately studied. Here we show that...

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Study challenges decades-old treatment guidelines for anorexia

EurekAlert! - Social and Behavioral Science — Thu, 08 Dec 2011 05:00:00 +0100

(University of California - San Francisco) Adolescents hospitalized with anorexia nervosa who receive treatment based on current recommendations for refeeding fail to gain significant weight during their first week in the hospital, according to a new study by UCSF researchers. (Source: EurekAlert! - Social and Behavioral Science)

Anorexic was a day from death after being called a fat ginger cow. Now Annabel is a healthy, happy, hairdresser

the Mail online | Health — Wed, 07 Dec 2011 08:36:48 +0100

Annabel Norris, (pictured), from West Yorkshire, starved herself to within one day of death after being bullied over her ginger hair. She has now overcome her condition to become a hairdresser. (Source: the Mail online | Health)

Phase I study for ridaforolimus, an oral mTOR inhibitor, in Japanese patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology — Mon, 05 Dec 2011 17:33:57 +0100

Conclusions Ridaforolimus was well tolerated up to a dose of 40 mg in Japanese patients. Preliminary evidence of antitumor activity was observed for patients with solid tumors. Further investigation at this dose is warranted. Content Type Journal ArticleCategory Clinical Trial ReportPages 1-7DOI 10.1007/s00280-011-1788-4Authors Yoshitaka Seki, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanNoboru Yamamoto, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanYosuke Tamura, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanYasushi Goto, Division of Internal Medicine, National Cancer Center...

The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization: A case control study

BioPsychiSocial Medicine — Mon, 05 Dec 2011 05:00:00 +0100

Background: The prevention of serious physical complications in anorexia nervosa (AN) patients is important. The purpose of this study is to clarify which physical and social factors are related to the necessity for urgent hospitalization of anorexia nervosa (AN) patients in a long-term starvation state. We hypothesized that the change of longitudinal BMI, body composition and social background would be useful as an index of the necessity for urgent hospitalization. Methods: AN patients were classified into;urgent hospitalization, due to disturbance of consciousness or difficulty walking(n=17); planned admission ( n=96); and outpatient treatment only groups (n=136). The longitudinal BMI pattern and the clinical features of these groups were examined.In the hospitalization groups, compariso...

Alliance-focused therapy for anorexia nervosa: Integrative relational and behavioral change treatments in a single-case experimental design.

Psychotherapy: Theory, Research, Practice, Training — Mon, 05 Dec 2011 05:00:00 +0100

This study provides preliminary support for the feasibility and effect of AFT and BCT, and highlights the importance of the alliance in treating adults with AN. Further research on emotion regulation in AN and its effect on the treatment relationship are needed. (PsycINFO Database Record (c) 2011 APA, all rights reserved) (Source: Psychotherapy: Theory, Research, Practice, Training)

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Brave Girl Eating: A Family’s Struggle with Anorexia

Psych Central — Thu, 01 Dec 2011 20:24:47 +0100

Between three and six percent of all teens struggle with some type of eating disorder, be it bulimia, binge eating, or anorexia. Because these illnesses involve eating, they seem to take a blow at family traditions, celebrations, and expressions of togetherness. Thus, parents, siblings, and even relatives all suffer, as Harriet Brown so adroitly shows us in her memoir Brave Girl Eating: A Family’s Struggle with Anorexia, a heartbreaking story about a mother who’s ready to march to the end of the earth to save her daughter from anorexia. From all outward appearances, Kitty looked like the girl who had it all: a straight-A student; an accomplished gymnast; and a happy, well-liked teen who loved reading, horses, and even cooking. By sixth grade, however, she began counting calorie...

Cisplatin/docetaxel/fluorouracil: Anorexia, neutropenia and pneumonia in an elderly patient: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

(Source: Reactions)

No association of brain‐derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics — Thu, 01 Dec 2011 05:00:00 +0100

AbstractThe Met66 allele of the Val66Met polymorphism in the brain‐derived neurotrophic factor (BDNF) gene has been reported to be associated with anorexia nervosa (AN), and also lower minimum body mass index (BMI) and higher harm avoidance in AN. We genotyped the Val66Met polymorphism (rs6265) in 689 AN cases and 573 control subjects. There were no significant differences in the genotype or allele frequencies of the Val66Met between AN and control subjects (allele wise, odds ratio = 0.920, 95% CI 0.785–1.079, P = 0.305). No difference was found in minimum BMIs related to Val66Met in AN (one‐way ANOVA, P > 0.05). Harm avoidance scores on the Temperament and Character Inventory were lower in the Met66 allele carriers (P = 0.0074) contrary to the previous report. Thu...

SirT1 Regulates Adipose Tissue Inflammation.

Diabetes — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSIONS Reduction of adipose tissue SirT1 expression, which leads to histone hyperacetylation and ectopic inflammatory gene expression, is identified as a key regulatory component of macrophage influx into adipose tissue during overnutrition in rodents and humans. Our results suggest that SirT1 regulates adipose tissue inflammation by controlling the gain of proinflammatory transcription in response to inducers such as fatty acids, hypoxia, and endoplasmic reticulum stress. PMID: 22110092 [PubMed - in process] (Source: Diabetes)

Hydration and nutrition at the end of life: a systematic review of emotional impact, perceptions, and decision‐making among patients, family, and health care staff

Psycho-Oncology — Thu, 01 Dec 2011 05:00:00 +0100

ConclusionsOur literature review reveals that these social, emotional, and clinical misperception elements should be considered in the decision‐making processes to help the triad develop functional forms of care at this final stage of life. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

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Sleep aid toxicosis in dogs: 317 cases (2004–2010)

Journal of Veterinary Emergency and Critical Care — Thu, 01 Dec 2011 05:00:00 +0100

ConclusionsOverall, the prognosis for dogs with sleep aid medication toxicosis was excellent, and no fatalities were reported in this clinical population. As significant clinical signs can still be seen with ingestion, appropriate decontamination is warranted in asymptomatic patients via emesis or gastric lavage, followed by activated charcoal administration. Symptomatic patients should be hospitalized for monitoring and supportive care for a minimum of 12 hours or until clinical signs resolve. (Source: Journal of Veterinary Emergency and Critical Care)

Changes in blood metabolic parameters during the development of Walker‐256 tumour‐induced cachexia in rats are not caused by decreased food intake

Cell Biochemistry and Function — Thu, 01 Dec 2011 05:00:00 +0100

Blood metabolic parameters of Walker‐256 tumour‐bearing rats, on days 5, 8, 11 and 14 after implantation of tumour, were compared with those of rats without tumour fed ad libitum (free‐fed control) or with reduced feeding (pair‐fed control), similar to the anorexic tumour‐bearing rats. Cachexia parameters and tumour mass also were investigated. In general, especially on day 14 after implantation of tumour, there was reduction of body mass, gastrocnemius muscle mass, food intake and glycemia and increase of blood triacylglycerol, free fatty acids, lactate and urea, compared with free‐fed controls rats. These changes did not occur in pair‐fed control, except a slight reduction of glycemia. Pair‐fed control showed no significant changes in blood cholesterol and glycerol in com...

[Functional MRI investigation of brain activity triggered by taste stimulation].

Magyar Sebeszet — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions: Our current fMRI investigations revealed different activations of numerous brain regions of normal and obese individuals, triggered by pleasant and unpleasant gustatory stimulation. Based on these results this method can help to recognize the role of the central nervous system in obesity, and may contribute to develop new therapies for weight loss. PMID: 22169342 [PubMed - in process] (Source: Magyar Sebeszet)

[Adolescent with anorexia nervosa: Consequences on bone mineralization.]

Archives de Pediatrie — Wed, 30 Nov 2011 05:00:00 +0100

CONCLUSION: Bone loss in anorexia nervosa is a complication that may be present as early as adolescence. It must be systematically searched for in all adolescents with severe malnutrition because, even if BMD correlated with nutritional parameters, no clinical predictor for osteoporosis or osteopenia could be identified in this study. PMID: 22137016 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Cognitive and physiological dissociations in response to emotional pictures in patients with anorexia

Journal of Psychosomatic Research — Wed, 30 Nov 2011 05:00:00 +0100

Abstract: Recent studies suggest that patients with anorexia may express dissociated cognitive and physiological reactivities to emotional stimuli. The present research aimed to compare subjective and autonomic responses to pleasant, unpleasant and neutral scenes during a categorization task and an activation rating task in anorexic (AN), alexithymic (AL), depressed (DEP) and control participants (CONT). The participants first categorized pictures according to their emotional valence, followed by a rating of their activation level, concomitant with the recording of skin conductance responses (SCRs). Main findings showed that the AN patients presented major difficulty in categorizing pictures, particularly neutral ones. Contrary to the AL participants, this difficulty did not induce signifi...

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Phase II study of bi-weekly irinotecan for patients with previously treated HER2-negative metastatic breast cancer: KMBOG0610B.

Breast Cancer — Tue, 29 Nov 2011 05:00:00 +0100

CONCLUSIONS: This study demonstrated that biweekly administration of 150 mg/m(2) irinotecan was feasible for patients with MBC treated previously with anthracyclines or taxanes. PMID: 22124996 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing

Journal of Human Nutrition and Dietetics — Mon, 28 Nov 2011 15:40:13 +0100

AbstractLoss of appetite is frequently observed during ageing, termed the ‘anorexia of ageing’. Ageing is associated with the inability to appropriately increase food intake after under‐eating in the short‐ and long‐term. Older people also report lower feelings of hunger and increased feelings of satiety and fullness. Gastrointestinal peptide hormones are a major part of the appetite regulatory system and are released in response to nutritional stimuli. They can be classified as: anorexigenic (satiety) [e.g. peptide tyrosine tyrosine (PYY), glucagon‐like peptide‐1, pancreatic polypeptide, oxyntomodulin and cholecystokinin (CCK)] or orexigenic (hunger) (e.g. ghrelin). Although the control of appetite is not fully understood, it is clear that these hormones play an important ro...

Anorexia and Cachexia

Cancer Network — Mon, 28 Nov 2011 12:00:00 +0100

This treatment guides covers the diagnostic criteria, management, nutritional counseling, appetite stimulants, enteral or parental stimulants, prophylactic therapy, and nutrition in end-of-life care for anorexia and cachexia. (Source: Cancer Network)

Sarcopenia in the elderly: Diagnosis, physiopathology and treatment

Maturitas — Mon, 28 Nov 2011 05:00:00 +0100

Abstract: Sarcopenia, defined as a syndrome rather than as a pathology, is the loss of muscle mass and function associated with age. Sarcopenia is an enigma for medicine, and despite the numerous publications available in the literature and the number of papers currently being published, there is no agreement about its definition, and even less about its root causes. One salient aspect that proves the lack of consensus is the fact that different working groups are still debating about the right name for this syndrome (which is associated with the loss of muscle mass and strength in the elderly).In hospitalized patients, sarcopenia has been shown to raise the risk of complications such as infections, pressure ulcers, loss of autonomy, institutionalization and poor quality of life, as well a...

In Anorexia Nervosa, Inner Conflicts Over The 'Real' Self Have Treatment Implications

Health News from Medical News Today — Sun, 27 Nov 2011 08:00:00 +0100

"It feels like there's two of you inside - like there's another half of you, which is my anorexia, and then there's the real K, the real me, the logic part of me, and it's a constant battle between the two." - 36 year old study participant with anorexia nervosa. People with anorexia nervosa struggle with questions about their real, or "authentic," self - whether their illness is separate from or integral to them - and this conflict has implications for compulsory treatment, concludes a study in the Hastings Center Report... (Source: Health News from Medical News Today)

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Alice Vinall went from obese to anorexic: Eating disorder battle could have killed her

the Mail online | Health — Sat, 26 Nov 2011 13:07:14 +0100

Going from fat to thin nearly killed Alice Vinall (pictured), of Hertfordshire, after she lost a staggering 11 stone in a bid to shed her bulk. (Source: the Mail online | Health)

Etiological Role of Childhood Emotional Trauma and Neglect in Adolescent Anorexia Nervosa: A Cross-Sectional Questionnaire Analysis

Psychopathology — Fri, 25 Nov 2011 19:37:45 +0100

Psychopathology 2012;45:61–66 (DOI:10.1159/000328580) (Source: Psychopathology)

Phase I/II study of gemcitabine as a fixed dose rate infusion and S-1 combination therapy (FGS) in gemcitabine-refractory pancreatic cancer patients

Cancer Chemotherapy and Pharmacology — Fri, 25 Nov 2011 17:57:53 +0100

Conclusion This combination regimen of FGS is active and well tolerated in patients with Gem-refractory PC. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00280-011-1786-6Authors Chigusa Morizane, Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanTakuji Okusaka, Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanHideki Ueno, Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 JapanShunsuke Kondo, Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045...

Two Patients With an Anti-N-Methyl-d-Aspartate Receptor Antibody Syndrome-Like Presentation and Negative Results of Testing for Autoantibodies

Pediatric Neurology — Fri, 25 Nov 2011 13:48:58 +0100

We describe two boys whose distinct and remarkable clinical pictures suggested the possibility of anti-N-methyl-d-aspartate receptor antibody encephalitis. Both patients responded to immunotherapy, but neither manifested that antibody. Patient 1 exhibited florid encephalopathy with psychotic manifestations including inappropriate affect, intermittent delirium, visual hallucinations, severe anorexia, agitation, paranoid ideation, and abnormal electroencephalogram results. He responded to intravenous immunoglobulin, with steady improvement over 3 months to almost complete remission for 1 year, followed by a relapse that again responded, more quickly, to intravenous immunoglobulin. A second relapse occurred 1 month later, and again responded to intravenous immunoglobulin. Patient 2 exhibited ...

MedWorm: Anorexia

Leptin in Anorexia and Cachexia Syndrome

Family Based Treatment for Anorexia Nervosa (The Maudsley Method)

Register Now for National Eating Disorders Awareness Week

Reversal of CRF- and stress-induced anorexia by an ayurvedic formulation

[Original Articles] Event-Related Potentials During Recognition of Semantic and Pictorial Food Stimuli in Patients With Anorexia Nervosa and Healthy Controls With Varying Internal States of Hunger

Somatic comorbidity in anorexia nervosa: First results of a 21-year follow-up study on female inpatients

A Mind Less Ordinary: My Experience of Living with Anorexia and Schizoaffective Disorder [Book reviews]

Calculation of Expected Body Weight in Adolescents With Eating Disorders

Leptin treatment of patients with anorexia nervosa? The urgent need for initiation of clinical studies

Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival

Psychosocial interventions for patients with chronic disease

Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation.

Small‐vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: Two subsets of giant cell arteritis

Spatial orientation constancy is impaired in anorexia nervosa

Fathers, Daughters and the "Touch Taboo"

Maternal eating disorders and infant temperament: Findings from the norwegian mother and child cohort study

Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect?

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

Are You Eating Your Sexual Desire?

Adolescent male with anorexia nervosa: a case report from Iraq

Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients

An open‐label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer

Treatment of Anorexia Nervosa in Children and Adolescents

The Curious Incident of the Fish Sticks in the Nighttime

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

Do the components of manualized family‐based treatment for anorexia nervosa predict weight gain?

Severe anorexia nervosa in men: Comparison with severe AN in women and analysis of mortality

Visual body perception in anorexia nervosa

Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion

Is attention to detail a similarly strong candidate endophenotype for anorexia nervosa and bulimia nervosa?

ACUTE center for eating disorders

Accuracy of self‐reported energy intake in weight‐restored patients with anorexia nervosa compared with obese and normal weight individuals

Borderline Personality: The Promiscuous Diagnosis

Anorexia Nervosa

School health lessons 'made our son anorexic after it made him paranoid about junk food'

Reframing eating during chemotherapy in cancer patients with chemosensory alterations.

Foreword

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors [Phase I and Clinical Pharmacology]

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women.

Dysphagia in severe anorexia nervosa: A case report

Symptoms of Anorexia Nervosa

The SCOFF Questionnaire

An

[World Report] Pro-anorexia websites pose public health challenge

Effects of Feiji Decoction for Soothing the Liver Combined with Psychotherapy on Quality of Life in Primary Lung Cancer Patients

“Photo-Therapy:” A Promising Intervention in Anorexia Nervosa?”

Phase I trial of oral S-1 combined with gemcitabine and cisplatin for advanced biliary tract cancer (KHBO1002)

“Photo-Therapy:” A Promising Intervention in Anorexia Nervosa?

Integrative role of neuropeptides and cytokines in cancer anorexia-cachexia syndrome.

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

Getting Your Eating Back on Track With a Food Plan

Letters: Anorexia Treatment (1 Letter)

Anti-epidermal growth factor receptor therapy for advanced head and neck squamous cell carcinoma: a meta-analysis

Mucinous Adenocarcinoma of Stomach

[Original Articles] Selective Attention of Patients With Anorexia Nervosa While Looking at Pictures of Their Own Body and the Bodies of Others: An Exploratory Study

Internalizing and Externalizing Behaviour Problems in Childhood Contribute to the Development of Anorexia and Bulimia Nervosa-A Study Comparing Sister Pairs. - Adambegan M, Wagner G, Nader IW, Fernández-Aranda F, Treasure J, Karwautz A.

Experts Urge BMI Method For Calculating Weight In Kids With Eating Disorders

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

Questioning the nutritional management of anorexia patients

[To Start Eating again Could Be Dangerous].

Pregnancy saved my life: Recovering anorexic reveals how desire for baby helped her defeat food demons

Low incidence of positive smooth muscle antibody and high incidence of isolated IgM elevation in Chinese patients with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome: a retrospective study

Hospital Treatment for Anorexia Is Questioned

Anorexic Patients Can Be Fed More Aggressively, Study Says

Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

Cognitive-behavioral treatment of body image disturbance in a congenitally blind patient with anorexia nervosa.

Abdominal Migraine in Children: Is It All in Their Heads?

Shared Written Case Formulations and Weight Change in Outpatient Therapy for Anorexia Nervosa: A Naturalistic Single Case Series

Emotional Processing Following Recovery from Anorexia Nervosa

Knowledge and Attitudes of Psychiatrists Towards Eating Disorders

Actinomyces turicensis infection mimicking ovarian tumour.

Bioimpedance and Bioimpedance Vector Analysis in patients with Anorexia Nervosa

The need for complex ideas in anorexia nervosa: Why biology, environment, and psyche all matter, why therapists make mistakes, and why clinical benchmarks are needed for managing weight correction

Cost‐of‐illness studies and cost‐effectiveness analyses in eating disorders: A systematic review

Novel Δ9‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects

Children suffering from anorexia at three

How Much Calorie Restriction Is Enough to Slow Brain Aging?

Theory of mind in bulimia nervosa

Effects of Feiji Decoction for Soothing the Liver Combined with Psychotherapy  on Quality of Life in Primary Lung Cancer Patients