MedWorm: Bed Wetting

Von Willebrand disease: Clinical and laboratory lessons learned from the large von Willebrand disease studies

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractDuring the past 25 years, our knowledge concerning the pathogenesis, diagnostic strategies and treatment of von Willebrand disease (VWD) has increased significantly. Following the immunological differentiation of factor VIII (FVIII) and von Willebrand factor (VWF) in the 1970s and the cloning of the FVIII and VWF genes in the mid‐1980s, substantial progress has been made in our understanding of this, the most common inherited bleeding disorder. We now recognize that VWD represents a range of genetic diseases all with the clinical endpoint of increased mucocutaneous bleeding. The molecular pathology of Type 2 and Type 3 VWD is now comprehensively documented and involves rare sequence variants at the VWF locus. In contrast, the genetic causation of Type 1 disease remains incomplete...

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Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels

Journal of Neurophysiology — Wed, 08 Feb 2012 05:00:00 +0100

This study reports the findings of two classes of corneal afferents excited by drying of the cornea (dry responses) in isoflurane-anesthetized rats: cold-sensitive (CS; 87%) and cold-insensitive (CI; 13%) neurons. Compared with CI neurons, CS neurons showed significantly higher firing rates over warmer corneal temperatures (~31–15°C) and greater responses to menthol, drying, and wetting of the cornea but lower responses when hyperosmolar solutions were applied to the ocular surface. We proposed that the dry responses of these corneal afferents derive from cooling and an increased osmolarity of the ocular surface, leading to the production of basal tears. An ocular application of the transient receptor potential channel TRPM8 antagonist BCTC (20 μM) decreased the dry responses ...

Lack of responsiveness to 1‐desamino‐d arginin vasopressin (desmopressin) in male patients with nephrogenic syndrome of inappropriate antidiuresis: from bench to bedside

European Journal of Clinical Investigation — Tue, 07 Feb 2012 02:06:13 +0100

Conclusions Coherent with in vitro observation in transfected cells, our clinical observations demonstrate that the R137C–V2R mutant is resistant to vasopressin stimulation in its physiological sites of expression. (Source: European Journal of Clinical Investigation)

Thermal materials: Pulling together to control heat flow

Nature Nanotechnology — Mon, 06 Feb 2012 05:00:00 +0100

Nature Nanotechnology 7, 82 (2012). doi:10.1038/nnano.2012.4 Author: Chris Dames The thermal conductivity of pairs of boron nanoribbons can be switched between high and low values by wetting the interface between the nanoribbons with various solutions. (Source: Nature Nanotechnology)

Overactive Bladder in Children

Current Bladder Dysfunction Reports — Thu, 02 Feb 2012 06:54:02 +0100

Abstract Overactive bladder in children is a bothersome and prevalent disorder that presents with a variety of different symptoms, ranging from irritative voiding symptoms such as frequency and urgency to urinary incontinence and/or nocturnal enuresis. In almost all cases of overactive bladder in neurologically intact children, the root cause has been linked to dysfunctional elimination syndrome. Although a great deal of progress has been made in the diagnosis and treatment of dysfunctional elimination, and previous harmful therapies have been for the most part abandoned, several unanswered questions remain regarding this disorder, which are partly due to a wide spectrum of presenting disorders and the difficulty of performing complex urodynamic evaluations in small childr...

Laxatives Cure Bed-Wetting for Many ChildrenLaxatives Cure Bed-Wetting for Many Children

Medscape Today Headlines — Wed, 01 Feb 2012 16:32:35 +0100

Laxatives can cure bed-wetting for many children. Occult megarectum is a commonly overlooked cause of nocturnal enuresis, can be detected by plain abdominal X-ray, and can be treated with laxatives. Medscape Medical News (Source: Medscape Today Headlines)

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Research Shows Bedwetting Can Be Due To Undiagnosed Constipation

Health News from Medical News Today — Tue, 31 Jan 2012 08:00:00 +0100

Bedwetting isn't always due to problems with the bladder, according to new research by Wake Forest Baptist Medical Center. Constipation is often the culprit; and if it isn't diagnosed, children and their parents must endure an unnecessarily long, costly and difficult quest to cure nighttime wetting. Reporting online in the journal Urology, researchers found that 30 children and adolescents who sought treatment for bedwetting all had large amounts of stool in their rectums, despite the majority having normal bowel habits... (Source: Health News from Medical News Today)

Study: Constipation May Cause Bed-wetting

MedicineNet Crohn's Disease General — Tue, 31 Jan 2012 07:00:00 +0100

Title: Study: Constipation May Cause Bed-wettingCategory: Health NewsCreated: 1/31/2012 11:00:00 AMLast Editorial Review: 1/31/2012 (Source: MedicineNet Crohn's Disease General)

Bed-wetting may be due to constipation

Health News - UPI.com — Sat, 28 Jan 2012 06:57:34 +0100

WINSTON-SALEM, N.C., Jan. 28 (UPI) -- Bed-wetting isn't always due to a bladder issue -- constipation is often the culprit -- U.S. researchers found. (Source: Health News - UPI.com)

Bedwetting can be due to undiagnosed constipation

ScienceDaily Headlines — Fri, 27 Jan 2012 18:57:57 +0100

Bedwetting isn’t always due to problems with the bladder. Constipation is often the culprit; and if it isn’t diagnosed, children and their parents must endure an unnecessarily long, costly and difficult quest to cure nighttime wetting. (Source: ScienceDaily Headlines)

Influence of Molecular Weight Dispersity of Poly{2-(perfluorooctyl)ethyl acrylate} Brushes on Their Molecular Aggregation States and Wetting Behavior

Macromolecules — Fri, 27 Jan 2012 18:43:14 +0100

MacromoleculesDOI: 10.1021/ma202300r (Source: Macromolecules)

Bedwetting can be due to undiagnosed constipation, research shows

EurekAlert! - Medicine and Health — Fri, 27 Jan 2012 05:00:00 +0100

(Wake Forest Baptist Medical Center) Bedwetting isn't always due to problems with the bladder. Constipation is often the culprit; and if it isn't diagnosed, children and their parents must endure an unnecessarily long, costly and difficult quest to cure nighttime wetting. (Source: EurekAlert! - Medicine and Health)

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Stereotactic Brainstem Biopsy in a Patient with Coagulopathy of Unclear Etiology: Case Report

min - Minimally Invasive Neurosurgery — Wed, 25 Jan 2012 05:00:00 +0100

We report the case of a patient with coagulopathy of unclear etiology undergoing a stereotactic brainstem biopsy.A medication scheme with tranexamic acid and desmopressin effectively decreased the patient’s bleeding time in vivo and the procedure was carried out without complications.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: min - Minimally Invasive Neurosurgery)

Graphene 'invisible' to water: How the extreme thinness of graphene enables near-perfect wetting transparency

ScienceDaily Headlines — Mon, 23 Jan 2012 17:31:31 +0100

Graphene is the thinnest material known to science. The nanomaterial is so thin, in fact, water often doesn’t even know it’s there. Engineering researchers coated pieces of gold, copper, and silicon with a single layer of graphene, and then placed a drop of water on the coated surfaces. Surprisingly, the layer of graphene proved to have virtually no impact on the manner in which water spreads on the surfaces. (Source: ScienceDaily Headlines)

Dimensional crossover and scaling behavior of a smectic liquid crystal confined to controlled-pore glass matrices

RSC - Soft Matter latest articles — Wed, 18 Jan 2012 18:44:09 +0100

Soft Matter, 2012, Advance ArticleDOI: 10.1039/C1SM06884A, PaperSamo Kralj, George Cordoyiannis, Dalija Jesenek, Aleksander Zidansek, Gojmir Lahajnar, Nikola Novak, Heinz Amenitsch, Zdravko KutnjakMemory-based weak surface-wetting potential could enable a dimensional-crossover phase behavior upon decreasing the characteristic confinement size.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

Role of Surface Charge and Hydrophobicity in the Three-Phase Contact Formation and Wetting Film Stability under Dynamic Conditions

The Journal of Physical Chemistry C — Wed, 18 Jan 2012 18:42:05 +0100

The Journal of Physical Chemistry CDOI: 10.1021/jp211378s (Source: The Journal of Physical Chemistry C)

Effects of Neurointermediate Pituitary Lobectomy and Desmopressin on Acute Experimental Autoimmune Encephalomyelitis in Lewis Rats

Neuroimmunomodulation — Tue, 17 Jan 2012 23:00:00 +0100

Neuroimmunomodulation 2012;19:148–157 (DOI:10.1159/000330578) (Source: Neuroimmunomodulation)

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Management of children with inherited mild bleeding disorders undergoing adenotonsillar procedures

International Journal of Pediatric Otorhinolaryngology — Tue, 17 Jan 2012 21:16:10 +0100

Conclusions: It is possible to obtain low rates of perioperative bleeding in children with mild bleeding disorders undergoing adenotonsillar procedures, provided there is a well-timed diagnosis and an adequate prophylaxis protocol. We believe that further efforts must be directed at preoperative diagnosis of mild bleeding disorders to ensure safer surgeries. (Source: International Journal of Pediatric Otorhinolaryngology)

Desmopressin: Neurological complications and hyponatraemia: 2 case reports

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

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Fluticasone propionate/mometasone: Enuresis (first report) following intranasal administration in a child: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

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Risperidone: Enuresis in a child, treated with imipramine: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

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Occurrence and Persistence of Bacterial Pathogens and Indicator Organisms in Beach Sand along the California Coast.

Applied and Environmental Microbiology — Fri, 13 Jan 2012 05:00:00 +0100

This study documents the presence of fecal indicators and bacterial pathogens in sand at 53 California marine beaches using both culture-dependent and -independent (PCR and QPCR) methods. Fecal indicator bacteria were widespread in California beach sand, with Escherichia coli and enterococci detected at 68% and 94% of beaches surveyed, respectively. Somatic coliphages and a Bacteroidales human-specific fecal marker were detected at 43% and 13% of the beaches, respectively. Dry sand samples from almost 30% of the beaches contained at least one of the following pathogens: Salmonella spp., Campylobacter spp., Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) which were detected at 15%, 13%,14%, and 3% of tested beaches, respectively. Fecal indicators and pathogens w...

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Predicting shape and stability of airwater interface on superhydrophobic surfaces comprised of pores with arbitrary shapes and depths

Applied Physics Letters — Sat, 07 Jan 2012 07:47:44 +0100

B. Emami, H. Vahedi Tafreshi, M. Gad-el-Hak, and G. C. Tepper An integro-differential equation for the three dimensional shape of airwater interface on superhydrophobic surfaces comprised of pores with arbitrary shapes and depths is developed and used to predict the static critical pressure under which such surfaces depart from the non-wetting state. Our equat ... [Appl. Phys. Lett. 100, 013104 (2012)] published Wed Jan 4, 2012. (Source: Applied Physics Letters)

Plasma corticotrophin response to desmopressin in patients with Cushing’s disease correlates with the expression of vasopressin receptor 2, but not with that of vasopressin receptor 1 or 3, in their pituitary tumours

Clinical Endocrinology — Sat, 07 Jan 2012 02:18:36 +0100

Conclusions We concluded that V2R was expressed on corticotrophinomas and that the level of its expression correlated well with the ACTH response to desmopressin in CD patients, although abundant expression of V1R and V3R was also found in almost all corticotroph tumours. Further studies are needed to elucidate the role of these receptors in the pathogenesis of CD. (Source: Clinical Endocrinology)

Directly fabricated multi-scale microlens arrays on a hydrophobic flat surface by a simple ink-jet printing technique

RSC - J. Mater. Chem. latest articles — Sat, 07 Jan 2012 00:11:54 +0100

J. Mater. Chem., 2012, Advance ArticleDOI: 10.1039/C2JM15576A, PaperJoo Yeon Kim, Karl Pfeiffer, Anja Voigt, Gabi Gruetzner, Juergen BruggerThe uniformed microlenses and microlens arrays can be simply fabricated using the ink-jet printing technique, and their geometrical and optical properties can be easily tunable and controllable by modifying the surface wetting conditions and changing the number of drops per microlens.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)

The influence of powder properties on the imbibation rate.

Colloids and Surfaces — Thu, 05 Jan 2012 05:00:00 +0100

Authors: Hellborg D, Bergenståhl B, Trägårdh C Abstract Mixing of powders into liquids is a common unit operation. Mixing can be divided into several steps, imbibation of the powder into the liquid being the first. Under some circumstances, such as when the powder has poor wetting properties, imbibation can be the rate-determining step. The effects of different powder properties on the imbibation rate were evaluated using an experimental imbibation model based on the imbibing process employed in an industrial powder-in-liquid mixer. A multivariate analysis of the results suggests that bulk density and capillary penetration rate, and to some extent cohesivity, play an important role in determining the powder imbibation rate. The results also suggest that the capillary penetration...

Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.

Am J Physiol Renal P... — Wed, 04 Jan 2012 05:00:00 +0100

Authors: Paliege A, Roeschel T, Neymeyer H, Seidel S, Kahl T, Daigeler AL, Mutig K, Mrowka R, Ferreri NR, Wilson BS, Himmerkus N, Bleich M, Bachmann S Abstract Na(+),K(+),2Cl--cotransporter (NKCC2) mediated NaCl reabsorption in the thick ascending limb (TAL) is stimulated by vasopressin (AVP) via V2 receptor/PKA/cAMP signaling. This process is antagonized by locally produced eicosanoids such as 20-HETE or prostaglandin E2 which are synthesized in a phospholipase A2 dependent reaction cascade. Using microarray-based gene expression analysis we found evidence for an AVP-dependent downregulation of the calcium-independent isoform of phospolipase A2, iPLA(2)β in the outer medulla of rats. In the present study we therefore examined the contribution of iPLA(2)β to NKCC2 regulation. Imm...

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Sleep deprivation induces excess diuresis and natriuresis in healthy children

AJP: Renal Physiology — Tue, 03 Jan 2012 05:00:00 +0100

This study was undertaken to show the effect of sleep deprivation (SD) on urine production in healthy children. Special focus was on gender and children at an age where enuresis is still prominent. Twenty healthy children (10 girls) underwent two 24-h studies, randomly assigned to either sleep or SD on the first study night. Diet and fluid intake were standardized. Blood samples were drawn every 4 h during daytime and every 2 h at night. Urine was fractionally collected. Blood pressure and heart rate were noninvasively monitored. Blood was analyzed for plasma antidiuretic hormone (AVP), atrial natriuretic peptide (ANP), angiotensin II, aldosterone, and renin. Urine was analyzed for aquaporin-2 and PGE2. Successful SD was achieved in all participants with a minimum of 4 h 50 min, and full-n...

Nocturnal enuresis with antipsychotic medication [EDITORIALS]

The British Journal of Psychiatry — Tue, 03 Jan 2012 05:00:00 +0100

Nocturnal enuresis can be discomfiting and troublesome. There is increasing evidence that as a side-effect of second-generation antipsychotics, particularly clozapine, it may be underrecognised. Direct but sensitive questioning may be required to elicit this side-effect. We briefly review possible mechanisms of this problem, and management and treatment options. (Source: The British Journal of Psychiatry)

Desmopressin vs Behavioral Change for Nocturnal EnuresisDesmopressin vs Behavioral Change for Nocturnal Enuresis

Medscape Today Headlines — Thu, 29 Dec 2011 04:00:00 +0100

Which method keeps pediatric patients with nocturnal enuresis dry -- the longest? Urologic Nursing (Source: Medscape Today Headlines)

Collecting duct cells that lack normal cilia have mislocalized vasopressin-2-receptors.

Am J Physiol Renal P... — Wed, 28 Dec 2011 05:00:00 +0100

Authors: Saigusa T, Reichert R, Guare J, Siroky BJ, Gooz M, Steele SL, Bell PD, Kolb RJ Abstract Polycystic kidney disease (PKD) is a ciliopathy characterized by renal cysts and hypertension. These changes are presumably due to altered fluid and electrolyte transport in the collecting duct (CD). This is the site where vasopressin (AVP) stimulates vasopressin-2-receptor (V2R)-mediated aquaporin-2 (AQP2) insertion into the apical membrane. Since cysts frequently occur in CD, we studied V2R and AQP2 trafficking and function in CD cell lines with stunted and normal cilia (cilia (-), cilia (+)) derived from the orpk mouse (hypomorph of the Tg737/Ift88 gene). Interestingly, only cilia (-) cells grown on culture dishes formed domes after apical AVP treatment. This observation led to our h...

Anisotropic Wetting of Microstructured Surfaces as a Function of Surface Chemistry

ACS Applied Materials and Interfaces — Tue, 27 Dec 2011 13:12:13 +0100

ACS Applied Materials & InterfacesDOI: 10.1021/am201104q (Source: ACS Applied Materials and Interfaces)

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Evaluation of bladder capacity in Korean children younger than 24 months: a nationwide multicenter study

World Journal of Urology — Mon, 26 Dec 2011 16:45:55 +0100

Conclusions These formulas may be useful for the diagnosis of abnormal bladder capacity and the evaluation of voiding dysfunction in Korean children younger than 24 months. Content Type Journal ArticleCategory Original ArticlePages 1-4DOI 10.1007/s00345-011-0762-4Authors Jae Min Chung, Department of Urology, Kosin University College of Medicine, Busan, KoreaKun Suk Kim, Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap 2-dong, Songpa-gu, Seoul, 138-736 KoreaSun-Ouck Kim, Department of Urology, Chonnam National University Medical School, Gwangju, KoreaJun Mo Kim, Department of Urology, Soonchunghyang University Hospital, College of Medicine, Soonchunghyang University, Bucheon, KoreaSungchan Park, Department of Uro...

Extreme water repellency of nanostructured low-surface-energy non-woven fabrics

RSC - Soft Matter latest articles — Fri, 23 Dec 2011 06:51:18 +0100

Soft Matter, 2012, Advance ArticleDOI: 10.1039/C1SM06867A, PaperBongsu Shin, Kwang-Ryeol Lee, Myoung-Woon Moon, Ho-Young KimNon-woven fabric networks consisting of microscale PET fibers that are nanotextured with an oxygen-plasma etching and hydrophobic coating show superior and robust water repellency. They repel water drops during and after vapor condensation and after wetting of low-surfae-energy liquids, implying potential applications to water harvesting and for surfaces prone to oily contamination.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

BED WETTING (Natural Medicine) Liquid [King Bio Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 23 Dec 2011 05:00:00 +0100

Updated Date: Dec 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A Systematic Review: The use of desmopressin for treatment and prophylaxis of bleeding disorders in pregnancy

Haemophilia — Thu, 22 Dec 2011 10:25:13 +0100

In conclusion, this review shows that DDAVP in selected cases is effective in reducing bleeding complications associated with pregnancy and childbirth with a good safety record. Further research is needed to confirm these findings as they are based on the currently available evidence from small studies and case series only. (Source: Haemophilia)

Complementary and miscellaneous interventions for nocturnal enuresis in children.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: There was weak evidence to support the use of hypnosis, psychotherapy, acupuncture, chiropractic and medicinal herbs but it was provided in each case by single small trials, some of dubious methodological rigour. Robust randomised trials are required with efficacy, cost-effectiveness and adverse effects clearly reported. PMID: 22161390 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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Tailoring Treatment of Monosymptomatic Nocturnal Enuresis: The Role of Maximum Voided Capacity

The Journal of Urology — Mon, 19 Dec 2011 05:00:00 +0100

Purpose: We evaluated bladder reservoir function in children with monosymptomatic nocturnal enuresis with and without response to desmopressin, and assessed the importance of first morning voiding when defining maximum voided volume. Materials and Methods: A total of 238 patients 5 to 15 years old with monosymptomatic nocturnal enuresis completed 2 weeks of enuresis recordings and 4 days of frequency-volume charts. Of the patients 186 completed subsequent home recordings during titration with desmopressin. Maximum voided volumes with and without the first morning void were calculated. Desmopressin response was defined as greater than 50% reduction in wet nights. Maximum voided volume with and without first morning voiding was evaluated as a prognostic factor for desmopressin response. ...

Monte Carlo simulation methods for computing the wetting and drying properties of model systems

Journal of Chemical Physics — Sat, 17 Dec 2011 13:52:59 +0100

Kaustubh S. Rane, Vaibhaw Kumar, and Jeffrey R. Errington We introduce general Monte Carlo simulation methods for determining the wetting and drying properties of model systems. We employ an interface-potential-based approach in which the interfacial properties of a system are related to the surface excess free energy of a thin fluid film in contact with a ... [J. Chem. Phys. 135, 234102 (2011)] published Fri Dec 16, 2011. (Source: Journal of Chemical Physics)

Maturation of prepulse inhibition (PPI) in childhood

Psychophysiology — Fri, 16 Dec 2011 05:00:00 +0100

AbstractIt is known that sensorimotor gating measured by the prepulse inhibition of the startle reflex (PPI) matures during childhood. Since certain disorders in children, for example, enuresis, show a significant loss in PPI, the PPI as a tool for investigating brainstem reflex control mechanism gains in importance. Therefore, it is crucial to know the natural course of PPI maturation in childhood. A total of 122 healthy children aged from 3–10 years and 10 healthy adults were examined. PPI was initiated by a 120 ms and a 60 ms prepulse and was measured by the EMG of M. orbicularis oculi. For the respective prepulse intervals, the PPI level in each age group increased from 3 to 9 or 10 years and showed a similar course. The findings confirm and extend knowledge about the maturation ...

Predicting Treatment Outcomes of Nocturnal Enuresis—Is it Possible?

The Journal of Urology — Thu, 15 Dec 2011 05:00:00 +0100

Monosymptomatic nocturnal enuresis is one of the most common nocturnal problems in children with an estimated prevalence of approximately 10% among 7-year-olds. Before the 1980s it was considered a benign condition with a chance of spontaneous cure of 15% per year. Insights into the pathophysiology were limited and no research was done. Treatment was mainly based on behavioral methods, wetting alarms and imipramine. (Source: The Journal of Urology)

Medical Management of Nocturnal Enuresis.

Paediatric Drugs — Wed, 14 Dec 2011 05:00:00 +0100

Authors: Deshpande AV, Caldwell PH Abstract Nocturnal enuresis, or bedwetting, is the most common cause of urinary incontinence in children. It is known to have a significant psychosocial impact on the child as well as the family. Nocturnal enuresis typically presents as failure to become dry at night after successful daytime toilet training. It can be primary or secondary (developing after being successfully dry at night for at least 6 months). Children with nocturnal enuresis may have excessive nocturnal urine production, poor sleep arousal and/or reduced bladder capacity. Alarm therapy is the recommended first-line therapy, with treatment choices being influenced by the presence or absence of the abnormalities mentioned above. Children with nocturnal enuresis may also have dayti...

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Use of desmopressin in children with inherited platelet dysfunctions undergoing adenotonsillar procedures.

Acta Otorrinolaringologica Espanola — Tue, 06 Dec 2011 05:00:00 +0100

CONCLUSIONS: The use of desmopressin allowed adequate perioperative bleeding prophylaxis management in children with mild inherited platelet dysfunction who underwent adenotonsillar procedures without presenting severe complications. PMID: 22153965 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)

An unusual case of abdominal arterial thrombosis in a young woman using desmopressin.

Clinical Biochemistry — Fri, 02 Dec 2011 05:00:00 +0100

We report an unusual case of severe abdominal arterial thrombosis in a young woman using oral desmopressin. Only a few cases with cerebrovascular accidents and coronary syndromes have been described so far, which could be attributed to intravenous administration of desmopressin. Because extensive diagnostic and laboratory investigations for (un)common coagulation disorders could not identify an alternative explanation associated with arterial thrombosis, we hypothesise that desmopressin in an oral dose of at least 200ug once daily must have been sufficient to cause this dramatic vascular complication. Supportive of our hypothesis, we found remarkably high levels of factor VIII activity, Von Willebrand factor (vWF) antigen and vWF ristocetin cofactor activity (268%, 740%, 590% respectively)...

Valproic acid: Enuresis in a child: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

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Treatment for Nocturnal Enuresis: The Current State in Japan

Pediatrics International — Thu, 01 Dec 2011 05:00:00 +0100

AbstractNocturnal enuresis is common problem in children with the prevalence as high as 20% among children aged five. Though nocturnal enuresis does not directly impose imminent danger on a patient's life, children with enuresis and their parents have been psychologically suffering in day‐to‐day life including school activities. Therefore, it is important to provide an explanation regarding the cause of nocturnal enuresis, how to approach the disorder, the course, and the outlook leading to the planned treatment.The cause of enuresis is considered to be a mismatch between nocturnal diuresis and nocturnal bladder capacity; nocturnal polyuria due to a lack of circadian change in anti‐diuretic hormones and a developmental delay in the voiding mechanisms. Therefore, patients can be class...

Menorrhagia and bleeding disorders in adolescent females.

Hamostaseologie — Tue, 29 Nov 2011 05:00:00 +0100

Authors: Halimeh S Abstract In women, von Willebrand disease (VWD) is the most common inherited bleeding disorder. Since VWD and other inherited bleeding disorders are autosomal disorders, they affect women and men. Menorrhagia, or heavy menstrual bleeding (HMB), is the most common symptom of women with bleeding disorder experience. Objectively, it is defined as bleeding that lasts for more than seven days or results in the loss of more than 80 ml of blood per menstrual cycle. The prevalence of menorrhagia in a woman with a bleeding disorder ranges from 32 to 100% in patients with VWD, from 5 to 98% in patients with a platelet dysfunction and from 35 to 70% in women with a rare factor deficiency. A detailed history and a careful physical exam are the first steps towards a diagnosis...

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The epidemiology of general paediatric outpatients referrals: 1988 and 2006

Child: Care, Health and Development — Fri, 25 Nov 2011 05:00:00 +0100

Conclusions More children were referred to paediatricians in 2006 compares with 1988. Services worked more efficiently, with better attendance, access and time to treatment. We provide information on changes in case mix that is not available elsewhere. This population‐based study thus gives a unique insight into changes in referrals to UK general paediatricians. (Source: Child: Care, Health and Development)

von Willebrand Disease: Local Diagnosis and Management of a Globally Distributed Bleeding Disorder