MedWorm: Behcet's Disease

What Is Behçet's Disease?

About.com Eating Disorders — Mon, 06 Feb 2012 05:00:00 +0100

Behçet's disease (Behcet's Disease) is an autoimmune disease that results from damage to blood vessels throughout the body, particularly veins. In an autoimmune disease, the immune system attacks and harms the body's own tissues. (Source: About.com Eating Disorders)

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JAK2 and STAT3 Polymorphisms in a Han Chinese Population with Behcet's Disease [Genetics]

Investigative Ophthalmology — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions. These results suggest that a STAT3 genetic polymorphism is associated with the susceptibility to BD. (Source: Investigative Ophthalmology)

Cerebral Abscesses in Behcet's Disease: A Case Report.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

Authors: Tokgoz S, Ogmegul A, Mutluer M, Kivrak AS, Ustun ME Abstract Behçet's disease is a multisystem relapsing inflammatory disorder of unknown cause. Neurological involvement is one of the most serious causes of long-term morbidity and mortality in Behçet's disease. Cerebral abscess is very rare in literature. A 45-yr-old man with Behçet's disease manifesting focal epileptic seizure and multiple cerebral abscesses is reported in the case. He was diagnosed with cerebral abscess and was treated with antibiotics but no improvement occurred. Excisional biopsy was performed and the lesions were consistent with abscess. The clinical state of the patient gradually improved. The patient had no further complications. The etiology, and clinical and magnetic resonance...

Association of amyotrophic lateral sclerosis and Behcet’s disease: is there a relationship? A multi-national case series

Clinical Rheumatology — Tue, 10 Jan 2012 17:00:11 +0100

Abstract Neurological involvement may be seen in 5–30% of the patients with Behcet’s disease (BD). Occasionally, parenchymal neurological involvement in BD can present as a spinal cord syndrome. However, motor neuron disease-like presentation is extremely uncommon. Here we are reporting five patients (all male; median age, 38) fulfilling both International Study Group criteria for BD and El Escorial criteria for amyotrophic lateral sclerosis (ALS). These patients were identified by a questionnaire sent to the members of the Neuro-Behcet Study Group of the International Study Group for BD. Three out of five patients had only motor presentations. In two patients, sensory and urinary manifestations were present as well. Spinal cord MRIs were normal in all, and brain MRIs ...

Asymptomatic giant coronary aneurysm in an adolescent with Behcet's syndrome

Pediatric Rheumatology — Fri, 06 Jan 2012 05:00:00 +0100

Conclusions: Vascular manifestations may be seen in Behcet's syndrome, including asymptomatic coronary aneurysm, which may be refractory to immunosuppression and ultimately require surgical intervention. Increased awareness is essential for prompt diagnosis and management. (Source: Pediatric Rheumatology)

Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease.

J Korean Med Sci — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Ahn JK, Cha HS, Lee J, Jeon CH, Koh EM Abstract Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding α-defensin-1 in samples from Korean individuals with Behcet's disease (BD) compared to healthy controls (HC). We recruited 55 BD patients and 35 HC. A duplex Taqman® real-time PCR assay was used to assess CN. Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 ± 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to in...

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Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease.

Molecular Biology Reports — Tue, 27 Dec 2011 05:00:00 +0100

Authors: Lee YH, Choi SJ, Ji JD, Song GG Abstract The aim of this study was to identify candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP → gene → pathway hypothesis. A psoriasis genome-wide association study (GWAS) dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of European descent and a BD GWAS dataset that contained 310,324 SNPs in 1,215 BD cases and 1,278 controls were used in this study. Identify candidate causal SNPs and pathways (ICSNPathway) analysis was applied to the GWAS datasets. ICSNPathway analysis identified 15 candidate causal SNPs and 28 candidate causal pathways. The top five candidate causal SNPs were rs1063478 (P = 1.45E-1...

CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population

Rheumatology — Wed, 21 Dec 2011 05:00:00 +0100

Conclusions. The results suggest that TT genotypes of rs4810485 and rs1883832 may be predisposing genotypes for BD, and that the rs4810485 GT genotype may be a protective genotype for BD. The two tested CD40 gene polymorphisms are not associated with VKH syndrome in the investigated Han Chinese population. (Source: Rheumatology)

Cytokines and Behcet's Disease.

Autoimmunity Reviews — Fri, 16 Dec 2011 05:00:00 +0100

Authors: Zhou ZY, Chen SL, Shen N, Lu Y Abstract Behcet's Disease (BD) is a systemic vasculitis of unknown etiology. Increasing studies find that a sophisticated interlacing cytokine network is closely implicated in the onset, evolution and even organ damages of the disease. Cytokines involved can be categorized as Th1 type, Th2 type, Th17 type, chemokines and other proinflammatory cytokines, etc. The vicious cycle of cytokine network plays a substantial role in the disease pathogenesis and even in organ lesions, and might be disorganized by blocking one of the key links of the cytokines, which in turn may provide essential clues to outlook the target therapy regimen of cytokine agents in BD. There have been a number of case reports of the positive efficacies of cytokine (and cytok...

The epidemiology and economic impact of varicella-related hospitalizations in Turkey from 2008 to 2010: a nationwide survey during the pre-vaccine era (VARICOMP study)

European Journal of Pediatrics — Thu, 15 Dec 2011 06:44:41 +0100

In conclusion, this study confirms that varicella-related hospitalizations are not uncommon in children, and two thirds of these children are otherwise healthy. The annual cost of hospitalization for varicella reflects only a small part of the overall cost of this disease, as only a very few cases require hospital admission. The incidence of this disease was higher in children <1 year of age, and there are no prevention strategies for these children other than population-wide vaccination. Universal vaccination is therefore the only realistic option for the prevention of severe complications and deaths. The surveillance of varicella-associated complications is essential for monitoring of the impact of varicella immunization. Content Type Journal ArticleCategory Original Ar...

Excessive CD4+ T cells co‐expressing IL‐17 and IFNγ in patients with Behcet's disease

Clinical and Experimental Immunology — Fri, 09 Dec 2011 05:00:00 +0100

SummaryExcessive Th1 cell activity has been reported in Behcet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating Th17 cells in BD.CD4+ CD45RO‐ (naïve) T cells were cultured with Th0, Th1, Th2 and Th17 related cytokines and antibodies, and their mRNA was studied by real‐time PCR. When naïve CD4+ T cells were cultured with Th1 and Th17 related cytokines, interferon (IFN)γ mRNA and interleukin (IL)‐17 mRNA were up‐regulated respectively in BD patients. Naïve CD4+ T cells cultured in a Th17 cell inducing condition expressed IL‐23 receptor (IL‐23R) mRNA excessively. IL‐17 mRNA expression was induced only when naïve CD4+ T cells were cultured in the presence of IL‐23. CD4+ T cells cultured ...

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Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet's disease

Journal of Inflammation — Mon, 21 Nov 2011 05:00:00 +0100

Conclusion: This study suggests that in vitro supplementation with flavonoids extracted from Artemisia herba alba could have potential immuno-modulatory effects characterised by a down-regulation and up-regulation of Th1 and Th2 cytokines, respectively. Moreover, flavonoids may prevent nitric oxide induced damages. (Source: Journal of Inflammation)

Clinical characteristics of pediatric-onset neuro-Behcet disease

Neurology — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions: Pediatric NBD comprises 3.6% of our whole NBD cohort, with a male predominance, mainly in the form of dural venous sinus thrombosis, whereas in the adult NBD population the dominant form of neurologic involvement is parenchymal, suggesting that the pathogenesis of NBD may be different according to the age at disease onset. (Source: Neurology)

Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis.

Immunobiology — Fri, 18 Nov 2011 05:00:00 +0100

Authors: Shim JA, Park S, Lee ES, Niki T, Hirashima M, Sohn S Abstract Galectin-9 (Gal-9) has been identified as a Tim-3 ligand (L). The Tim-3-Tim-3L interaction serves as a specific down-regulator of the Th1 immune response. It has been reported that Tim-3 expression is higher in patients with inflammatory disorders such as rheumatoid arthritis compared to controls. In a herpes simplex virus-induced Behcet's disease (BD) mouse model, Tim-3 was expressed in a similarly high level. The expression of Gal-9 in macrophages from BD-like mice was lower than in asymptomatic BD normal mice; therefore, we injected 100μg of Gal-9 into BD-like mice five times at 3day intervals and subsequently observed changes in symptoms over 15days. Gal-9 improved the symptoms of inflammation, decreased th...

Follow-up of children with PFAPA syndrome into early adulthood

The Journal of Pediatrics — Thu, 10 Nov 2011 19:14:12 +0100

This study represents 12-21 years of follow up of 60 patients who were diagnosed with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) by strict clinical criteria as young children and were entered into the Vanderbilt registry. The findings add important and predominantly reassuring facts about natural history of PFAPA. The average age of subjects at follow-up was 20 years. Although the majority of patients had resolution of febrile episodes (with mean duration of episodes for 6.3 years), 9 patients continued to have periodic fevers. There was no appreciable difference in age of onset, intervals of well-being, or manifestations during febrile episodes in those who did or did not have resolution of the syndrome during childhood. In patients who had persistent ...

Prevalence of uveitis in indigenous populations presenting to remote clinics of Central Australia

Clinical and Experimental Ophthalmology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions: A distinct pattern of uveitis appears to be present amongst indigenous population of remote Central Australia. Posterior uveitis was commoner than anterior uveitis with a predominance of toxoplasma retinochoroiditis. Environmental factors appeared to be more important in this genetically distinct population, with infective causes and ocular trauma being the most common aetiologies of uveitis. (Source: Clinical and Experimental Ophthalmology)

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There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations

British Journal of Ophthalmology — Fri, 21 Oct 2011 04:00:00 +0100

Conclusions The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations. (Source: British Journal of Ophthalmology)

The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

Journal of Pediatric Surgery — Sat, 01 Oct 2011 04:00:00 +0100

Conclusion: A single intraperitoneal dose of 5-FU had a preventive effect on stricture formation after caustic esophageal burn. This observation suggests that 5-FU may prevent this undesirable complication in the clinical setting. Clinical studies are now required to verify this form of treatment. Local intraesophageal application of 5-FU immediately after the burn injury was not effective. Further investigations are required to determine the appropriate timing of application of 5-FU at the local site of injury. (Source: Journal of Pediatric Surgery)

Effect of Infliximab on Gene Expression Profiling in Behcet's Disease [Immunology and Microbiology]

Investigative Ophthalmology — Thu, 29 Sep 2011 04:00:00 +0100

Conclusions. Several up- or downregulated genes identified in this study may be candidates for further investigation in identifying the molecular mechanism of infliximab in the treatment of Behçet's disease with refractory uveoretinitis. (Source: Investigative Ophthalmology)

MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases.

Journal of Autoimmunity — Wed, 28 Sep 2011 04:00:00 +0100

In this study we found that a subset of human CD4(+) T cells expressing MCAM (CD146) have higher mRNA levels of RORC2, IL-23R, IL-26, IL-22, IL-17A, but not IFN-γ, compared to CD4(+) T cell not expressing CD146. Upon TCR stimulation with CD3/CD28, CD4(+)CD146(+) T cells secrete significantly more IL-17A, IL-6, and IL-8 than do CD4(+)CD146(-) T cells. Low frequencies of CD4(+)CD146(+) T cells are found in the circulation of healthy adults, but the frequency of these cells is significantly increased in the circulation of patients with inflammatory autoimmune diseases including Behcet's, sarcoidosis and Crohn's disease. Patterns of gene expression and cytokine secretion in these cells are similar in healthy and disease groups. In Crohn's disease, the increase in CD4(+)CD146(+) cells in the ...

54 Interferon-{alpha} reduces early atherosclerosis in patients with Behcet's Syndrome

Heart — Fri, 23 Sep 2011 04:00:00 +0100

Conclusion This is the first clinical study to test the effects of interferon-α on atherosclerosis, and maybe the first to test the effects of any cytokine. Reduction in carotid wall volume maybe related to stimulation of homeostatic IgM antibodies with improved clearance of biologically active oxidatively-modified lipids and reduction in endothelial dysfunction. It remains to be determined whether interferon-α has the same effects in otherwise healthy, non-Behcet's Syndrome individuals. (Source: Heart)

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TIRAP Ser180Leu polymorphism is associated with Behcet's disease

Rheumatology — Tue, 20 Sep 2011 04:00:00 +0100

Conclusion. TLR expression showed no difference in tissue from patients with BD compared with either disease or healthy controls. Likewise, SNPs in TLR genes were no different from healthy controls. The association with the increased function variant of TIRAP suggests that encounter with a pathogen at mucosal sites will lead to increased cytokine production and tissue damage with persistence of mucosal lesions. (Source: Rheumatology)

Age, gender and disease-related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behcet's disease

Rheumatology — Tue, 20 Sep 2011 04:00:00 +0100

Conclusion. BD is a rare, chronic multi-systemic vasculitis and interaction of activated platelets with leucocytes has been linked to pathological disorders associated with vascular inflammation. Importantly, this study demonstrates that platelet microparticle activation is increased in BD. Also, this is the first report in which changes in platelet activation in BD are concordant with the observations that BD disease activity diminishes with age. (Source: Rheumatology)

Behcet disease and celiac disease: to screen or not?

Rheumatology International — Wed, 31 Aug 2011 15:57:09 +0100

Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00296-011-2132-3Authors Bilal Ergül, Department of Gastroenterology, Ankara Education and Research Hospital, Keklikpınarı mahallesi, 240 sokak, Duru apartmanı, 8/6, Dikmen, Çankaya, Ankara, TurkeyErdem Koçak, Department of Gastroenterology, Ankara Education and Research Hospital, Keklikpınarı mahallesi, 240 sokak, Duru apartmanı, 8/6, Dikmen, Çankaya, Ankara, TurkeySeyfettin Köklü, Department of Gastroenterology, Ankara Education and Research Hospital, Keklikpınarı mahallesi, 240 sokak, Duru apartmanı, 8/6, Dikmen, Çankaya, Ankara, Turkey Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)

The downside of sex with Neanderthals

Guardian Unlimited Science — Thu, 25 Aug 2011 18:01:00 +0100

Some modern humans carry immune genes that originated in Neanderthals and a related species. But these genes may have come at a priceOne question seemed to hang in the air more than any other when scientists first turned the powerful techniques of modern genetics on the fragile and damaged remains of ancient humans: did we or didn't we? Have sex with them, that is.The answer came after years of painstaking work, when material extracted from the leg of a Neanderthal and the fingerbone of a Denisovan, an apparent sister species, yielded readable DNA. It turned out that most of us have some of their genes. The Neanderthals contributed up to 4% of modern Eurasian genomes, while the Denisovans contributed roughly 4-6% of modern Melanesian genomes. That doesn't happen by holding hands. And so th...

There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations.

The British Journal of Ophthalmology — Wed, 24 Aug 2011 23:00:00 +0100

ConclusionsThe tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations. PMID: 21873313 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

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[Behcet syndrome: Thirty comments with lung and vascular injury of peripheral vessels.]

Presse Medicale — Mon, 22 Aug 2011 23:00:00 +0100

CONCLUSION: The vascular involvement in Behcet's disease is manifested primarily by thrombophlebitis. Achieving blood pressure, less common, is problematic therapeutic because of the recurrent and life threatening. PMID: 21868192 [PubMed - as supplied by publisher] (Source: Presse Medicale)

Decreased ocular inflammatory attacks and background retinal and disc vascular leakage in patients with Behcet's disease on infliximab therapy

British Journal of Ophthalmology — Thu, 18 Aug 2011 23:00:00 +0100

Conclusion Infliximab over the first year of treatment appeared effective in reducing ocular inflammatory attacks, as well as background retinal and disc vascular leakage, in patients with refractory uveoretinitis associated with Behçet's disease. (Source: British Journal of Ophthalmology)

Macular hole in Behçet's disease

Indian Journal of Ophthalmology — Mon, 08 Aug 2011 23:00:00 +0100

Conclusions: MH in patients with BD may lead to significant visual disability. Surgical intervention does not seem to have any potential beneficial effect on the VA, probably due to significant macular ischemia and sequelae from the ocular inflammation. (Source: Indian Journal of Ophthalmology)

Influence of age at diagnosis and sex on clinical course and long‐term prognosis of intestinal Behcet's disease

Inflammatory Bowel Diseases — Mon, 25 Jul 2011 23:00:00 +0100

Conclusions:In intestinal BD, younger age at diagnosis is associated with a more severe clinical course and a poorer prognosis. However, although some clinical manifestations at initial diagnosis tend to be more severe in male patients, clinical outcomes do not differ significantly according to sex. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases)

Subclinical left ventricular dysfunction in Behcet's disease assessed by two-dimensional speckle tracking echocardiography

European Journal of Echocardiography — Tue, 12 Jul 2011 23:00:00 +0100

Conclusion Longitudinal myocardial systolic function assessed by STE, which is a sensitive marker of subclinical ventricular dysfunction is impaired in BD. Increased NT-proBNP levels may be a sign of subclinical ventricular dysfunction in these patients. (Source: European Journal of Echocardiography)

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Behcet's Disease (Syndrome) with Myalgia and Its Response to Intravenous Amino Acids: A Case Series

Pain Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Conclusion. Physicians treating myalgia should observe for signs of Behcet's disease, such as oral and genital ulcerations, and consider intravenous amino acids if steroids are not effective. (Source: Pain Medicine)

Subannular ring in Behcet's disease [Letters to the Editor]

European Journal of Cardio-Thoracic Surgery — Mon, 27 Jun 2011 23:00:00 +0100

(Source: European Journal of Cardio-Thoracic Surgery)

Association of mitochondrial polymorphism m.709G>A with Behcet's disease

Annals of the Rheumatic Diseases — Mon, 27 Jun 2011 23:00:00 +0100

The involvement of nuclear genes in Behçet's disease (BD) risk has been investigated, but the role of the mitochondrial DNA (mtDNA) has been completely neglected. Mitochondria are the main intracellular source of reactive oxygen species produced during normal aerobic metabolism via the electron transport chain and since mitochondrial dysfunction may underlie a multitude of clinical features in multifactorial and multisystemic diseases such as BD, we assessed whether mtDNA single nucleotide polymorphisms (SNPs) and haplogroups confer susceptibility to BD. A total of 615 patients and 434 controls from Iran were enrolled in this study. BD diagnosis was made according to the revised International Criteria for Behçet's Disease1 (ICBD cases). A total of 494 patients also fulfilled ...

[A Case of Natural Killer Like T Cell Lymphoma Misdiagnosed as Behcet's Enteritis of the Terminal Ileum.]

Korean J Gastroenter... — Fri, 24 Jun 2011 23:00:00 +0100

Authors: Joo YW, Koh DH, Lee KN, Lee HL, Jun DW, Yoon BC, Choi HS, Lee OY Primary natural killer (NK) cell like T cell lymphoma of the terminal ileum is extremely rare. It most frequently occurs in the nasal or paranasal areas and less frequently in the skin, the soft tissue, and the gastrointestinal tract. NK/T cell lymphoma involving gastrointestinal tract has characteristic endoscopic features of Inflammatory bowel disease. We herein describe a first case of primary NK/T cell lymphoma misdiagnosed as Behcet's enteritis of the terminal ileum colonoscopically and complicated by cecal bleeding and perforation. PMID: 21694489 [PubMed - as supplied by publisher] (Source: Korean J Gastroenter...)

Varicocele and Epididymitis in Behcet Disease

Journal of Ultrasound in Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions— The incidence of varicocele was increased in Behçet disease. Whether varicocele confers fertility problems in patients with Behçet disease and the underlying mechanism for a possible association are yet to be determined. (Source: Journal of Ultrasound in Medicine)

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A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2

Rheumatology — Wed, 15 Jun 2011 23:00:00 +0100

(Source: Rheumatology)

Evaluation of Parenchymal Neuro-Behcet Disease by Using Susceptibility-Weighted Imaging [BRAIN]

American Journal of Neuroradiology — Sun, 12 Jun 2011 23:00:00 +0100

CONCLUSIONS: Most of the lesions in parenchymal NBD were found to be hemorrhagic with SWI, supporting the proposed venous theory in pathology. In addition, compared with T2 FSE and T2*GE sequences, SWI was more successful in the determination of widespread involvement of the disease, particularly in nonchronic cases. (Source: American Journal of Neuroradiology)

Surgical Treatment of Peripheral Aneurysms in Patients with Behcet's Disease.

PubMed: Eur J Vasc Endovasc ... — Wed, 01 Jun 2011 23:00:00 +0100

CONCLUSION: Surgery for peripheral aneurysms in BD is warranted in many instances. Results of operation can be improved by prolonged monitoring. However, despite all efforts, peripheral aneurysm involvement in BD worsens the prognosis. PMID: 21641238 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)

Clinical outcomes and prognostic factors for thiopurine maintenance therapy in patients with intestinal Behcet's disease

Inflammatory Bowel Diseases — Tue, 24 May 2011 23:00:00 +0100

Conclusions:Thiopurine therapy showed a relatively good effect for maintenance of remission in intestinal BD patients. However, a younger age at diagnosis and a lower hemoglobin level were associated with a poor response to thiopurines, necessitating early adoption of effective alternative therapeutic options in these risk groups. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases)

IL18 Polymorphism Is Associated with Behcet's Disease But Not Lupus in Patients from Turkey.

J Rheumatol — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Htoon J, Nadig A, Hughes T, Yavuz S, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH PMID: 21532063 [PubMed - in process] (Source: J Rheumatol)

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Successful treatment with adalimumab in a familial case of gastrointestinal Behcet's disease

Journal of Critical Care — Tue, 26 Apr 2011 23:00:00 +0100

We present here two siblings with a history of recurrent oral and genital ulcers, neurological and gastrointestinal manifestations. The diagnosis of Behçet's disease in a context of familial aggregation was assumed. Facing repeated steroid-dependent flares and failure of maintenance therapies with colchicine and intolerance to pentoxifilline and disulone, adalimumab was started. Rapid response was observed in both patients, with clinical remission after induction therapy, which currently sustains under maintenance schedule. This case report suggests the effectiveness of adalimumab as first anti-TNFα in case of steroid-dependent/resistant gastrointestinal BD. (Source: Journal of Critical Care)

Evaluation of Parenchymal Neuro-Behcet Disease by Using Susceptibility-Weighted Imaging [BRAIN]

American Journal of Neuroradiology — Wed, 20 Apr 2011 23:00:00 +0100

Cross-cultural adaptation and validation of Behcet's disease quality of life questionnaire

BMC Medical Research Methodology - Latest articles — Tue, 19 Apr 2011 23:00:00 +0100

Conclusion: This cross-cultural adaptation has produced an Arabic BD-QoL questionnaire that is now available for use in clinical settings and in research studies, among Arabic speaking patients. (Source: BMC Medical Research Methodology - Latest articles)

Recurrence of Secondary Glomerular Disease after Renal Transplantation.

Clinical Journal of the American Society of Nephrology : CJASN — Wed, 13 Apr 2011 23:00:00 +0100

Authors: Ponticelli C, Moroni G, Glassock RJ Summary The risk of a posttransplant recurrence of secondary glomerulonephritis (GN) is quite variable. Histologic recurrence is frequent in lupus nephritis, but the lesions are rarely severe and usually do not impair the long-term graft outcome. Patients with Henoch-Schonlein nephritis have graft survival similar to that of other renal diseases, although recurrent Henoch-Schonlein nephritis with extensive crescents has a poor prognosis. Amyloid light-chain amyloidosis recurs frequently in renal allografts but it rarely causes graft failure. Amyloidosis secondary to chronic inflammation may also recur, but this is extremely rare in patients with Behcet's disease or in those with familial Mediterranean fever, when the latter are treated with ...

Hughes-Stovin Syndrome

BioMed Central — Tue, 12 Apr 2011 23:00:00 +0100

(HSS) is a very rare clinical disorder characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. Less than 40 published cases of HSS have been described in English medical literature so far. The exact etiology and pathogenesis of HSS is unknown; possible causes include infections and angiodysplasia. HSS has also been considered as a variant of Behcet's disease (BD). Patients with HSS usually present with cough, dyspnea, fever, chest pain and haemoptysis. The management of HSS can either be medical or surgical. Medical management includes the use of steroids and cytotoxic agents. Cyclophosphamide, in particular, is a favored therapeutic agent in this regard. Antibiotics have no proven role in HSS while anticoagulants and thombolytic agents are generally contraind...

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[Arthritis, Erythema Nodosum and Genital Ulcerations.]

Praxis — Tue, 12 Apr 2011 23:00:00 +0100

Authors: Arnold C, Revaz S, Dudler J Behcet's disease is a disease of unknown etiology resting in between vasculitis, spondyloarthropathy and autoinflammatory diseases. If his predilection for the population originating from the Silk Road is well known, as are its cutaneous, ocular and vascular manifestations, this case illustrates the non-specificity of those manifestations, the diagnostic difficulties and the importance of routinely assessing for eyes and bowel diseases in this type of patient. PMID: 21484713 [PubMed - as supplied by publisher] (Source: Praxis)

Vascular manifestations of Behcet's disease: report of a case and review of the literature.

Phlebology — Wed, 06 Apr 2011 23:00:00 +0100

We report an ABD case, presenting with a thrombotic occlusion of the inferior vena cava. The authors review the recent literature, emphasizing the spectrum of vascular manifestations accompanying Behçet's disease. PMID: 21478143 [PubMed - as supplied by publisher] (Source: Phlebology)

Supra-annular aortic replacement in Behcet's disease: A new surgical modification to prevent valve detachment

International Journal of Cardiology — Wed, 06 Apr 2011 23:00:00 +0100

Behcet's disease is a multisystem inflammatory disorder dominated clinically by recurrent oral and genital ulceration, uveitis, and erythema nodosum, which rarely involves the cardiovascular system .However, the cardiovascular complications of Behcet's disease occasionally require surgical intervention. Often, valve replacement is often the only alternative as inflammation-induced tissue fragility completely destroys the native aortic valve . Surgical treatment of this condition carries a high risk of postoperative morbidity as a result of valve detachment or pseudoaneurysms at anastomosis sites . Consequently, we developed a new maneuver for patients with recurrent aortic valve detachment due to Behcet's disease and have obtained good results. (Source: International Journal of Cardiology)

Urokinase plasminogen activator receptor levels in Behcet's disease

Thrombosis Research — Wed, 06 Apr 2011 23:00:00 +0100

Conclusion: This finding is important since this is the first study regarding uPAR levels in Behcet's disease. (Source: Thrombosis Research)

Elevated Oxidative Stress Markers and its Relationship With Endothelial Dysfunction in Behcet Disease

Angiology — Tue, 05 Apr 2011 23:00:00 +0100

Behçet’s disease (BD) is a multisystemic disorder characterized by endothelial dysfunction. However, the relationship between oxidative stress and endothelial function has not been clearly shown. We investigated the relationship between oxidative stress markers and endothelial function in patients with BD. Patients with BD (n = 40) having active disease and sex- and age-matched 40 controls were included. Endothelial function was assessed by flow-mediated dilatation (FMD) technique. Serum gamma-glutamyltransferase (GGT) and high-sensitive C-reactive protein levels (hsCRP) were measured in all participants. Brachial artery FMD was significantly lower in patients with BD than in controls. Gamma-glutamyltransferase and hsCRP levels were higher in patients with BD than in controls....

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Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease

Arthritis Research and Therapy — Thu, 24 Mar 2011 00:00:00 +0100

Conclusions: HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and positive pathergy test, respectively. (Source: Arthritis Research and Therapy)

Skin Prick Test with Self-Saliva in Patients with Oral Aphthoses: A Diagnostic Pathergy for Behcet's Disease and Recurrent Aphthosis.

Inflammation and Allergy Drug Targets — Thu, 24 Mar 2011 00:00:00 +0100

Authors: Togashi A, Saito S, Kaneko F, Nakamura K, Oyama N There may be some difficulties to differentiate Behcet's disease (BD), recurrent aphthosis (RA), and herpetic aphthous ulceration, from other mimicking oral disorders. Despite of unexpected sensitivity and responsiveness, the skin pathergy test regarding a hypersensitivity to streptococcal antigen(s) has long been thought as one of auxiliary diagnostic benefits for BD. To determine the potential usefulness and disease specificity of the pathergy reaction, a skin prick test with neat and filter-sterilized saliva was performed on the forearm skin of 26 individuals; 10 patients with BD (8 incomplete type without uveitis, 1 complete type, and 1 neurological type), 5 with RA, 3 with herpetic oral aphthosis, 2 with erythema nodosum a...

Infliximab for patients with neuro-Behcet's disease: case series and literature review

Clinical Rheumatology — Wed, 23 Mar 2011 16:56:14 +0100

This study aims to report the therapeutic effects of anti-tumor necrotic factor antibody, infliximab, for treatment of neuro-Behcet's disease (NBD) and to review the literature. We described four patients (all male, median age 40 years old) who fulfilled the International Study Group criteria for Behcet's disease (BD) and presented with neurological complication. Demographic and clinical characteristics of the patients, dose, therapeutic effects, and adverse drug reaction (ADR) of infliximab were reported. Two patients had secondary progressive, one relapsing progressive, and one primary progressive course (median duration of BD and NBD 11 and 2 years, respectively). Two patients each received infliximab with 3 and 5 mg/kg infusions, respectively. The patients received...

Lower Initial Doses of IFN Effective for Behcet's Uveitis

Medscape Ophthalmology Headlines — Tue, 22 Mar 2011 01:33:27 +0100

Starting with a low dose of interferon (IFN) for Behcet's uveitis and raising it as necessary works just as well as higher-dose protocols, with fewer side effects, Turkish researchers say. Reuters Health Information (Source: Medscape Ophthalmology Headlines)

Relationship between serum infliximab levels and acute uveitis attacks in patients with Behcet disease

British Journal of Ophthalmology — Thu, 17 Mar 2011 00:00:00 +0100

Conclusion Monitoring infliximab serum concentrations is useful in determining the effectiveness of infliximab treatments for uveitis in Behçet disease. (Source: British Journal of Ophthalmology)

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Long-term Efficacy and Safety of Low-Dose and Dose-Escalating Interferon Alfa-2a Therapy in Refractory Behcet Uveitis [Clinical Sciences]

Archives of Opthalmology — Mon, 14 Mar 2011 00:00:00 +0100

Conclusion A treatment protocol using a low-dose and dose-escalating therapy with interferon alfa-2a was able to control and achieve remission of uveitis in most patients with refractory ocular Behçet disease. (Source: Archives of Opthalmology)

Surgical Management of a Left Anterior Descending Pseudoaneurysm Related to Behcet's Disease [CASE REPORTS]

The Annals of Thoracic Surgery — Wed, 23 Feb 2011 00:00:00 +0100

A 22-year-old woman suffering from Behcet's disease and severe angina was diagnosed with a left anterior descending coronary artery giant pseudoaneurysm. Preoperative investigations, surgical management, and its principles, as well as specific postoperative follow-up considerations are described. (Source: The Annals of Thoracic Surgery)

Rapidly growing aortic arch aneurysm in Behcet's disease [Case report - Aortic and aneurysmal]

Interactive CardioVascular and Thoracic Surgery — Wed, 23 Feb 2011 00:00:00 +0100

We present a patient with a nine-year history of Behçet's disease (BD), who developed a rapidly expanding aneurysm of the aortic arch. Three-dimensional computed tomography demonstrated a saccular aortic arch aneurysm with a maximal diameter of 5 cm. No bacteria were detected by serial blood cultures. The aneurysm, however, showed a multi-lobular cavity, mimicking an infectious aneurysm. Therefore, we prescribed antibacterial agents for one week. The patient still had a high-fever and an elevated C-reactive protein level thereafter. Aortic arch replacement was performed emergently. Because we were unable to determine whether the aneurysm was caused by infection or BD, the implanted prosthetic graft and the anastomotic sites were covered with a pedicle graft of the greater oment...

Serum Anti-Saccharomyces Cerevisiae Antibodies in Greek Patients with Behcet's Disease.

Yonsei Medical Journal — Tue, 22 Feb 2011 15:30:36 +0100

Authors: Vaiopoulos G, Lakatos PL, Papp M, Kaklamanis F, Economou E, Zevgolis V, Sourdis J, Konstantopoulos K We tested 59 Greek patients with Behcet's Disease (BD) for serum anti-Saccharomyces cerevisiae antibodies. No increase of these antibodies was detected in the cases compared to 55 healthy unrelated blood donors from the same population. This finding is in contrast with the correlation between Saccharomyces cerevisiae antibodies and BD as reported in other populations. It seems that environmental factors may contribute to disease expression in different populations, producing different effects according to the individual's genetic predisposition. Saccharomyces cerevisiae antibodies do not seem to be of any significance in the Greek population. PMID: 21319357 [PubMed - in pro...

A single infliximab infusion vs corticosteroids for acute panuveitis attacks in Behcet's disease: a comparative 4-week study

Rheumatology — Mon, 21 Feb 2011 00:00:00 +0100

Conclusion. A single infusion of infliximab should always be considered, even as an adjunct therapy, for the control of acute panuveitis attacks in BD. (Source: Rheumatology)

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Ciclosporin: Neurological manifestations in a patient with Behcet's disease?: case report

Reactions — Thu, 17 Feb 2011 16:50:41 +0100

(Source: Reactions)

Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model.

Herpes — Wed, 09 Feb 2011 00:00:00 +0100

Authors: Choi B, Kim J, Lee ES, Bang D, Sohn S Synthesized pyridine compound derivatives (SK94, SK126) from a natural lead source were administered to mice to test for possible anti-TNF alpha and anti-inflammatory activities. Lipopolysaccharide (LPS)-induced TNF alpha production was analyzed in the endothelial cells, Raw 264.7 cells, and serum of normal mice after treatment with SK compounds. These compounds were also orally administered to a herpes simplex virus (HSV)-induced Behcet's disease mouse model to investigate their anti-inflammatory therapeutic effect. TNF alpha production was inhibited in a dose-dependent manner in the SK94 treated cells. E-selectin, VCAM-1, and ICAM-1 mRNA levels were also down-regulated. Treatment with 30mg/kg SK94 inhibited 55% of the TNF alpha productio...

Budd-Chiari syndrome in a 25-year-old woman with Behcet's disease: a case report and review of the literature

BioMed Central — Mon, 07 Feb 2011 00:00:00 +0100

Conclusion: Severe vascular complications of Budd-Chiari syndrome in patients with Behcet's disease are much more common in young adult male patients; we present a rare case of Budd-Chiari syndrome in a young Afro-Brazilian woman with Behcet's disease. (Source: BioMed Central)

High-Dose Cyclophosphamide Without Stem Cell Rescue for the Treatment of Refractory Behcet's Disease

Seminars in Arthritis and Rheumatism — Fri, 04 Feb 2011 05:00:00 +0100

Conclusions: These data suggest high-dose cyclophosphamide therapy without stem cell rescue as an alternative for the treatment of refractory BD. (Source: Seminars in Arthritis and Rheumatism)

Induction of Regulatory T Cells by Infliximab in Behcet's Disease [Immunology and Microbiology]

Investigative Ophthalmology — Fri, 21 Jan 2011 00:00:00 +0100

Conclusions. Anti–TNF- therapy may be useful for patients with ocular complications of Behçet's disease who have a decreased percentage of peripheral Treg cells. (Source: Investigative Ophthalmology)

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Timing of recurrent uveitis in patients with Behcet's disease receiving infliximab treatment

British Journal of Ophthalmology — Thu, 20 Jan 2011 00:00:00 +0100

Conclusion Infliximab is effective for suppressing recurrence of uveitis in Behçet's disease, but responses to infliximab differ among patients. Careful observation following infliximab infusion is necessary to manage the recurrence of uveitis during treatment. (Source: British Journal of Ophthalmology)

IFN-{alpha} blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease

Rheumatology — Mon, 17 Jan 2011 00:00:00 +0100

Conclusions. In vitro experiments showed that IFN- could inhibit IL-17 expression and increased IL-10 production by PBMCs and CD4+ T cells. The inhibitory role of IFN- on IL-17 was partly mediated by IL-10. IFN- activity was mediated via STAT2 phosphorylation. (Source: Rheumatology)

Genetic susceptibility to Behcet's disease: role of genes belonging to the MHC region

Rheumatology — Mon, 17 Jan 2011 00:00:00 +0100

Conclusion. Further studies must be addressed to clarify the functional relevance of the different genes found to be associated with disease susceptibility and the potential interactions between genes located within and outside the MHC region. (Source: Rheumatology)

A case of anterior ischemic optic neuropathy associated with Behcet's disease

Eye — Fri, 07 Jan 2011 08:00:00 +0100

Authors: S Kim, S Kang & Y J Roh (Source: Eye)

Expression of a soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) correlates with clinical disease activity in intestinal Behcet's disease

Inflammatory Bowel Diseases — Thu, 06 Jan 2011 00:00:00 +0100

Conclusions:Serum sTREM‐1 levels were more highly correlated with disease activity than were CRP levels or ESR in patients with intestinal BD, suggesting that serum sTREM‐1 level could be a potential marker for the assessment of disease activity of intestinal BD. (Inflamm Bowel Dis 2011;) (Source: Inflammatory Bowel Diseases)

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Xoma gets up to $505M for diabetes drug

bizjournals.com Health Care:Biotechnology headlines — Tue, 04 Jan 2011 05:00:00 +0100

Xoma Ltd. will receive $35 million and up to $470 million in milestones and royalties for its potential once-a-month diabetes drug, XOMA-052. The Berkeley company (NASDAQ: XOMA) said French pharmaceutical company Servier will fund the first $50 million of development expenses and half of further expenses for Behcet's uveitis. Xoma is in Phase III testing of the drug for that disease, and Xoma will retain the right to commercialize 052 for that disease and other inflammatory and oncology... (Source: bizjournals.com Health Care:Biotechnology headlines)

Major Vessel Involvement in Behçet's Disease: An Update

Medscape Rheumatology Headlines — Thu, 30 Dec 2010 05:12:54 +0100

This review explores the complications of and the best therapies for Behcet disease. Current Opinion in Rheumatology (Source: Medscape Rheumatology Headlines)

Femoral Profunda Artery Aneurysm as an Unusual First Presentation of Behcet Disease

Vascular and Endovascular Surgery — Wed, 29 Dec 2010 00:00:00 +0100

We present a case of an African American man diagnosed with Behcet disease from his presentation with PFAA. He was also found to have a synchronous hypogastric artery aneurysm. The patient was immediately treated with corticosteroids and infliximab to control systemic and vascular inflammation, returning 1 month later for surgery. He had a repair of the left PFAA with a common femoral to profunda femoris artery bypass with reversed saphenous vein graft and aneurysmorrhaphy. When a patient presents with an aneurysm in an unusual location, it is important to evaluate for other aneurysms. A careful history and physical examination is also required to see if the aneurysm may be part of an underlying systemic syndrome. (Source: Vascular and Endovascular Surgery)

Serum Salusin-Alpha Level in Rheumatoid Arthritis.

Regulatory Peptides — Thu, 23 Dec 2010 00:00:00 +0100

Authors: Ozgen M, Koca SS, Dagli N, Balin M, Ustundag B, Isik A Rheumatoid arthritis (RA), a chronic inflammatory disease, leads to early and accelerated atherosclerosis; however, its pathogenesis is not yet fully documented. Salusin-α and β are novel bioactive peptides. Salusin-α suppresses macrophage foam cell formation, while salusin-β stimulates. Moreover, decreased serum salusin-α level has been reported previously in patients with coronary artery disease. The aims of the study were to assess serum salusin-α level and its association with predictors of atherosclerosis in a cohort of patients with RA. The study included 56 RA patients, 37 Behcet's disease (BD) patients, and 29 healthy controls (HC). TNF-α, IL-6 and salusin-α levels, homeostasis model assessment (HOMA-IR) in...

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Imaging as a Biomarker in Behcet Disease: Prognostic and Therapeutic Implications of Serial Pulmonary CT Angiography

American Journal of Roentgenology — Wed, 22 Dec 2010 00:00:00 +0100

(Source: American Journal of Roentgenology)

Decreased ocular inflammatory attacks and background retinal and disc vascular leakage in patients with Behcet's disease on infliximab therapy.

The British Journal of Ophthalmology — Wed, 22 Dec 2010 00:00:00 +0100

Anti-TNF Agents for Behçet's Disease: Analysis of Published Data on 369 Patients

Seminars in Arthritis and Rheumatism — Mon, 20 Dec 2010 00:00:00 +0100

Conclusions: Although more controlled data are needed, there is enough published experience to suggest that TNF blockade represents an important therapeutic advancement for patients with severe and resistant, or intolerant, to standard immunosuppressive regimens BD. (Source: Seminars in Arthritis and Rheumatism)

Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese patients.

Human Immunology — Tue, 14 Dec 2010 00:00:00 +0100

Authors: Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N Action of Toll-like receptors (TLRs) is deeply associated with defense mechanisms of the innate and adaptive immune responses to microbial pathogens. There have been reports of genetic polymorphisms within the TLR7 gene being closely related to a variety of inflammatory and infectious diseases. Bechet's disease (BD) is an autoflammatory disease, and the pathogenesis has yet to be fully discovered. We investigated whether polymorphisms of toll-like receptor 7 (TLR7) are associated with BD by analyzing the frequency of eight single nucleotide polymorphisms (SNPs) within 200 Japanese BD patients and 102 randomized controls. We genotyped 9 single-nucleotide polymorphisms (SNPs) ...

Extracranial Carotid Artery Aneurysm due to Behcet's Disease [CASE STUDIES]

Asian Cardiovascular and Thoracic Annals — Mon, 13 Dec 2010 00:00:00 +0100

We describe a surgically treated case of Behçet’s disease in a 28-year-old man who presented with a rapidly enlarging left common carotid artery aneurysm. (Source: Asian Cardiovascular and Thoracic Annals)

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Registries in rheumatological and musculoskeletal conditions. Paediatric Behcet's disease: an international cohort study of 110 patients. One-year follow-up data

Rheumatology — Wed, 08 Dec 2010 00:00:00 +0100

Conclusion. The expert committee has classified the majority of patients in the BD group although they presented with few symptoms independently of BD classification criteria. (Source: Rheumatology)

Ciclosporin: Neuro-Behcet's disease: case report

Reactions — Mon, 06 Dec 2010 15:50:32 +0100

(Source: Reactions)

Pediatric Behcet's Disease and Thromboses.

J Rheumatol — Mon, 15 Nov 2010 00:00:00 +0100

CONCLUSION: Thromboses are a serious complication of BD and may occur early in the disease course. The presence of thrombophilic markers could increase the risk of thrombosis in BD, but the size of our population does not allow any conclusion. An international cohort (PED-BD) is currently in place and will allow study of such cases longitudinally, as well as assessment of the elements that correlate with an increased risk of thrombosis in children with BD. PMID: 21078724 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Response: Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

The Tohoku Journal of Experimental Medicine — Sat, 13 Nov 2010 22:50:04 +0100

Authors: Acikgoz N, Karincaoglu Y, Ermis N, Yagmur J, Atas H, Kurtoglu E, Cansel M, Barutcu I, Pekdemir H, Ozdemir R PMID: 21068521 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)

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Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

The Tohoku Journal of Experimental Medicine — Sat, 13 Nov 2010 22:50:04 +0100

Authors: Lee WS, Kim TY PMID: 21068520 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)

Prognostic factors and long‐term clinical outcomes for surgical patients with intestinal Behcet's disease

Inflammatory Bowel Diseases — Mon, 08 Nov 2010 00:00:00 +0100

Conclusions:According to the current study, volcano‐shaped ulcers, higher CRP levels, a history of postoperative steroid therapy, and the presence of intestinal perforations detected by pathology were factors of a poor prognosis. Careful follow‐up is required in surgical patients with these risk factors, who are at high risk for recurrence and reoperation. (Inflamm Bowel Dis 2010;) (Source: Inflammatory Bowel Diseases)

Plasma Homocysteine Level in Patients with Behcet's Disease with or without Thrombosis.

Archives of Iranian Medicine — Mon, 01 Nov 2010 00:00:00 +0100

CONCLUSION: Hyperhomocysteinaemia may be an independent risk factor for vascular thrombosis in patients with BD. This is the first study showing a negative correlation between HLA-B51 and plasma homocysteine level. PMID: 21039001 [PubMed - in process] (Source: Archives of Iranian Medicine)

An Audit of Behcet's Syndrome Research: A 10-year Survey.

J Rheumatol — Thu, 14 Oct 2010 23:00:00 +0100

CONCLUSION: A considerable number of the published research articles have methodological weaknesses. The generalizability of what we observed in Behcet's syndrome to other research topics needs to be formally studied. PMID: 20952472 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Thrombosis and Behcet's syndrome in non-endemic regions

Rheumatology — Wed, 13 Oct 2010 23:00:00 +0100

(No abstract is available for this citation) (Source: Rheumatology)

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Impact of Behcet's syndrome on health-related quality of life: influence of the type and number of symptoms

Rheumatology — Wed, 13 Oct 2010 23:00:00 +0100

Conclusions. BS has a considerable impact on quality of life. Both the type and number of symptoms affect the quality of life of adults with BS. (Source: Rheumatology)

Vision- and Health-Related Quality of Life in Patients With Behcet Uveitis [Clinical Sciences]

Archives of Opthalmology — Mon, 11 Oct 2010 19:51:02 +0100

Conclusions General health is more affected than visual functioning in patients with Behçet uveitis. Sociodemographic and clinical variables had a significant effect on vision- and health-related quality of life. Multivariate analysis of the NEI-VFQ-25 and SF-36 subscales revealed that each subscale item score is affected by additional factor(s) other than those analyzed here. (Source: Archives of Opthalmology)

Homocysteine in vascular Behcet disease: a meta-analysis.

Arteriosclerosis, Thrombosis and Vascular Biology — Thu, 30 Sep 2010 23:00:00 +0100

CONCLUSIONS: Our results suggest that hyperhomocysteinemia may be considered to be associated with thrombosis in BD patients. PMID: 20634474 [PubMed - indexed for MEDLINE] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

Expression and Function of Inducible Costimulator on Peripheral Blood CD4+ T Cells in Behcet's Patients with Uveitis: A New Activity Marker? [Immunology and Microbiology]

Investigative Ophthalmology — Tue, 28 Sep 2010 20:42:50 +0100

Conclusions. High ICOS expression in BD patients with uveitis contributed to the upregulation of IFN-, IL-17, and TNF- production, suggesting that abnormal ICOS costimulation may play an immunopathologic role in the pathogenesis of uveitis in BD. (Source: Investigative Ophthalmology)

Interferon-{alpha} treatment for acute myelitis and intestinal involvement in severe Behcet's disease

QJM — Thu, 23 Sep 2010 08:46:36 +0100

(No summary is available for this citation) (Source: QJM)

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Fulminant Evolution of Behcet Disease

American Journal of Roentgenology — Tue, 21 Sep 2010 18:02:53 +0100

(No abstract is available for this citation) (Source: American Journal of Roentgenology)

Gender influence on ocular manifestations and their outcome in Behcet’s Disease. A long-term follow-up of up to 20 years

Clinical Rheumatology — Tue, 21 Sep 2010 11:23:04 +0100

Abstract It is of general belief that males are prone to more frequent, more severe manifestations, and less favorable outcome. We evaluated this hypothesis in ophthalmological manifestations (OM) of Behcet's Disease (BD). Visual acuity (VA), anterior uveitis, posterior uveitis (PU), and retinal vasculitis (RV) were checked, according to Ben Ezra, in 1,515 patients with eye lesions. The data at baseline and last visit were compared. Male/female ratio was 1.2 in the BD registry (6,500 patients) and 1.51 for OM patients (Chi2 = 98.962, p < 0.0001). The patients-year-follow-up was 4,987. All parameters improved significantly from the baseline. Mean VA improved from 4.87 to 5.35 for males (p < 0.0001) and from 5.20 to 5.74 for females (p < 0.0001). Diff...

Endovascular treatment of aortic aneurysms in patients with Behcet's disease: report of two cases

Jornal Vascular Brasileiro — Fri, 10 Sep 2010 10:18:59 +0100

We report our experience with two Behcet's disease patients who presented with aortic aneurysms and were submitted to endovascular therapy, and describe their respective follow-ups. Current pathophysiology, diagnosis, and treatment approaches were reviewed. Our experience suggests that the endovascular approach, combined with adequate immunosuppressive treatment, is an excellent therapeutic option for some patients with Behcet's disease suffering from aneurysms. (Source: Jornal Vascular Brasileiro)

Behcet's Takes Higher Toll in Men (CME/CE)

MedPage Today Rheumatology — Wed, 08 Sep 2010 03:13:09 +0100

(MedPage Today) -- Men with Behçet's disease are much more likely than women to die of this chronic multisystem vasculitis, a large French study found. (Source: MedPage Today Rheumatology)

Behcet's disease and heart transplantation: A word of caution

The Journal of Heart and Lung Transplantation — Mon, 06 Sep 2010 23:00:00 +0100

We report the first orthotopic heart transplant with >1-year survival in a patient with Behcet's disease despite major complications. The investigators remain pessimistic about cardiac transplantation in patients with Behcet's disease until advances in preventing recurrent vascular pathology ensue. (Source: The Journal of Heart and Lung Transplantation)

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Warfarin: Severe renal haemorrhage and haematoma in Behcet's syndrome: case report

Reactions — Fri, 03 Sep 2010 05:55:26 +0100

(Source: Reactions)

Behcet's disease

Journal of Medical Biography — Thu, 26 Aug 2010 22:35:21 +0100

(Source: Journal of Medical Biography)

Horizon scanning: XOMA 052 designated orphan drug by FDA and EMEA for treatment of behcet's disease

NeLM - News — Wed, 04 Aug 2010 23:00:00 +0100

Source: GlobeNewswire Area: News The FDA and the EMEA have designated XOMA 052, an antibody to interleukin-1 beta, an orphan drug for the treatment of Behcet's disease. In June 2010, XOMA announced positive results from an open-label pilot study of XOMA 052 in Behcet's disease patients who were suffering from uveitis, despite maximal doses of immunosuppressive medicines. All seven patients who enrolled in the trial displayed rapid reduction of intraocular inflammation and improvement in visual acuity or other ophthalmic measures following a single treatment. XOMA has now completed a phase II clinical trial in uveitis of Behcet's disease. (Source: NeLM - News)

XOMA 052 Designated Orphan Drug by FDA for Treatment of Behcet's Disease

Medical News (via PRIMEZONE) — Wed, 04 Aug 2010 12:00:00 +0100

BERKELEY, Calif., Aug. 4, 2010 (GLOBE NEWSWIRE) -- XOMA Ltd. (Nasdaq:XOMA), a leader in the discovery and development of therapeutic antibodies, announced that the U.S. Food and Drug Administration has designated XOMA 052, an antibody to interleukin-1 beta, an orphan drug for the treatment of Behcet's disease. As previously announced, the Committee for Orphan Medical Products of the European Medicines Agency has recommended the granting of orphan medicinal product designation for XOMA 052 for the same indication in the European Union. (Source: Medical News (via PRIMEZONE))

XOMA 052 Orphan Drug Designation for Behcet's Disease Recommended by European Medicines Agency

Medical News (via PRIMEZONE) — Thu, 29 Jul 2010 12:00:00 +0100

BERKELEY, Calif., July 29, 2010 (GLOBE NEWSWIRE) -- XOMA Ltd. (Nasdaq:XOMA), a leader in the discovery and development of therapeutic antibodies, announced that the Committee for Orphan Medical Products of the European Medicines Agency (EMA) has adopted a positive opinion and recommends the granting of orphan medicinal product designation for XOMA 052, an antibody to interleukin-1 beta, for the treatment of Behcet's disease. Positive opinions are submitted to the European Commission for decision and are generally adopted within 30 days of receipt. (Source: Medical News (via PRIMEZONE))

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Disease genes that followed the Silk Road identified

ScienceDaily Headlines — Sun, 25 Jul 2010 07:21:15 +0100

Researchers have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. (Source: ScienceDaily Headlines)

Genetics Home Reference: Behcet disease

NLM General Announcements — Mon, 19 Jul 2010 18:49:51 +0100

(Source: NLM General Announcements)

NIH Genetic Collaboration Brings New Meaning to the Silk Road

MedlinePlus Health News — Thu, 15 Jul 2010 01:17:12 +0100

Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases - Related MedlinePlus Page: Behcet's Syndrome (Source: MedlinePlus Health News)

Homocysteine in Vascular Behcet Disease. A Meta-Analysis.

Arteriosclerosis, Thrombosis and Vascular Biology — Wed, 14 Jul 2010 23:00:00 +0100

CONCLUSIONS: Our results suggest that hyperhomocysteinemia may be considered to be associated with thrombosis in BD patients. PMID: 20634474 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

Research On Behcet's Disease Brings New Meaning To The Silk Road

Health News from Medical News Today — Wed, 14 Jul 2010 11:00:00 +0100

Researchers with the National Institutes of Health have found susceptibility to Behcet's diseaseBehcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. Although the Greek physician Hippocrates described Behcet's disease (pronounced BET'-chet's), more than 2,000 years ago, the condition existed in relative obscurity until the early 20th century... (Source: Health News from Medical News Today)

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NIH Genetic Collaboration Brings New Meaning to the Silk Road

National Institutes of Health (NIH) News Releases — Mon, 12 Jul 2010 20:21:00 +0100

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. (Source: National Institutes of Health (NIH) News Releases)

NIH genetic collaboration brings new meaning to the Silk Road

EurekAlert! - Medicine and Health — Mon, 12 Jul 2010 04:00:00 +0100

(NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases) Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. (Source: EurekAlert! - Medicine and Health)

IL-17 gene polymorphism is associated with Vogt-Koyanagi-Harada disease but not with Behcet's disease in a Chinese Han population.

Human Immunology — Tue, 06 Jul 2010 23:00:00 +0100

Authors: Shu Q, Yang P, Hou S, Li F, Chen Y, Du L, Jiang Z Interleukin (IL)-17 has been shown to play an important role in certain autoimmune diseases. The present study was performed to investigate the association of IL-17A and IL-17F gene polymorphisms with two autoimmune uveitis entities, Vogt-Koyanagi-Harada (VKH) disease and Behcet's disease (BD), in a Chinese Han population. A total of 362 BD patients, 385 VKH patients and 412 controls were genotyped for IL-17A/rs2275913 and IL-17F/rs763780 using polymerase chain reaction restricted fragment length polymorphism. The result showed that the genotype and allele distribution of the two SNPs in all subjects were in Hardy-Weinberg equilibrium. A significantly decreased frequency of IL-17F/rs763780 C allele (P=0.006, Pc=0.036) and an in...

2.20. Behcet's disease and miscellaneous rheumatic conditions

APLAR Journal of Rheumatology — Wed, 30 Jun 2010 23:00:00 +0100

(Source: APLAR Journal of Rheumatology)

Infracardiac total anomalous pulmonary venous drainage with unusual presentation

Indian Journal of Pediatrics — Tue, 29 Jun 2010 16:34:29 +0100

Abstract Total anomalous pulmonary venous drainage (TAPVD) is a rare entity which forms approximately 0.4 to 2% of all congenital heart disease. The infracardiac type usually involve obstructions on pulmonary venous connections and comprising a quarter of all TAPVD cases. The clinical findings in patients with obstructed infracardiac TAPVD could mimic respiratuary distress of several different etiologies during first hours of life. In this article, we present a case of a neonate with infracardiac type of TAPVD presented with only distinct subcutaneous veins of abdominal and thoracic wall. Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-010-0105-2Authors Murat Muhtar Yilmazer, Izmir Dr. Behcet Uz Children’s Hospital Department of Pediatric Cardi...

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Behcet's disease in Iran: analysis of 6500 cases

APLAR Journal of Rheumatology — Sun, 27 Jun 2010 23:00:00 +0100

Conclusion: Behcet's disease is mainly seen in young people. The most frequent symptoms are mucocutaneous, ocular and joint manifestations. Comparison with large series did not show major differences. (Source: APLAR Journal of Rheumatology)

Relationship between serum infliximab levels and acute uveitis attacks in patients with Behcet disease.

The British Journal of Ophthalmology — Sat, 26 Jun 2010 23:00:00 +0100

Conclusion Monitoring infliximab serum concentrations is useful in determining the effectiveness of infliximab treatments for uveitis in BehÃ§et disease. PMID: 20584716 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

The role of Qa-2, the functional homolog of HLA-G, in a Behcet's disease-like mouse model induced by the herpes virus simplex

Journal of Inflammation — Wed, 23 Jun 2010 23:00:00 +0100

Conclusions: Silencing Qa-2 by injecting siRNA into mice resulted in deterioration of symptoms in BD-like mice. (Source: Journal of Inflammation)

Interferon Alpha Achieves Remission of Uveitis in Behcet's Disease

Medscape Rheumatology Headlines — Wed, 23 Jun 2010 15:58:48 +0100

Almost all patients with severe uveitis due to Behcet's disease responded to treatment with interferon alpha in a German study, the researchers report. Reuters Health Information (Source: Medscape Rheumatology Headlines)

Rituximab in intractable ocular lesions of Behcet's disease; randomized single-blind control study (pilot study)

APLAR Journal of Rheumatology — Tue, 22 Jun 2010 23:00:00 +0100

Conclusion: Rituximab was efficient in severe ocular manifestations of BD, TADAI improved significantly after 6 months with rituximab, but not with CCT. (Source: APLAR Journal of Rheumatology)

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IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

Annals of the Rheumatic Diseases — Mon, 21 Jun 2010 10:27:41 +0100

Conclusions This study, for the first time, identified a strong association of an SNP of IL-23R, rs17375018, with BD. The results also suggested that both rs11209032 AA and rs17375018 GG of IL-23R are predisposing genotypes for BD and that the AGCG haplotype may provide protection against BD. (Source: Annals of the Rheumatic Diseases)

Behcet's Disease Increases Mortality, Especially in Men

Medscape Rheumatology Headlines — Thu, 17 Jun 2010 21:27:08 +0100

Patients with Behcet's disease (BD), particularly men, have higher than average long-term mortality rates, French researchers reported online May 23rd in Arthritis & Rheumatism. Reuters Health Information (Source: Medscape Rheumatology Headlines)

Positive Clinical Findings Presented on XOMA 052 in Debilitating Eye Disease

Medical News (via PRIMEZONE) — Thu, 17 Jun 2010 12:00:00 +0100

ROME, June 17, 2010 (GLOBE NEWSWIRE) -- XOMA Ltd. (Nasdaq:XOMA), a leader in the discovery and development of therapeutic antibodies, announced positive results from an open-label pilot study of XOMA 052 in patients with uveitis of Behcet's disease who were suffering from vision-threatening exacerbations despite maximal doses of immunosuppressive medicines. All seven patients who enrolled in the trial displayed rapid reduction of intraocular inflammation and improvement in visual acuity or other ophthalmic measures following a single treatment with XOMA 052, a therapeutic antibody candidate that inhibits the inflammatory cytokine interleukin-1 beta (IL-1 beta). The preliminary results of the first clinical trial of XOMA 052 in patients with uveitis of Behcet's disease were presented today ...

Timing of recurrent uveitis in patients with Behcet's disease receiving infliximab treatment.

The British Journal of Ophthalmology — Thu, 10 Jun 2010 23:00:00 +0100

Conclusion Infliximab is effective for suppressing recurrence of uveitis in BehÃ§et's disease, but responses to infliximab differ among patients. Careful observation following infliximab infusion is necessary to manage the recurrence of uveitis during treatment. PMID: 20542984 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Phenotype and functional changes of Vgamma9/Vdelta2 T lymphocytes in Behcet's disease and the effect of infliximab on Vgamma9/Vdelta2 T cell expansion, activation and cytotoxicity

BioMed Central — Wed, 02 Jun 2010 23:00:00 +0100

Conclusions: All together these data indicate that infliximab is capable of interfering with Vgamma9/Vdelta2 T cell function in BD and although cell culture models cannot reliably predict all of the potential effects of the drug in vivo, our results present the possibility that this drug may find use in a range of immunological disorders, characterized by dysregulated cell-mediated immunity. (Source: BioMed Central)

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Pimecrolimus versus placebo in genital aphthous ulcers of Behcet's disease: a randomized double-blind controlled trial

APLAR Journal of Rheumatology — Mon, 24 May 2010 23:00:00 +0100

Conclusion: Pimecrolimus is safe and efficient in the treatment of BD genital ulcers, by accelerating the healing process. (Source: APLAR Journal of Rheumatology)

Immune Responses to Interphotoreceptor Retinoid-Binding Protein and S-Antigen in Behcet's Patients with Uveitis [Immunology and Microbiology]

Investigative Ophthalmology — Wed, 19 May 2010 15:54:39 +0100

This study characterized immune responses to retinal autoantigens augmented in patients with ocular Behçet's disease. (Source: Investigative Ophthalmology)

Contractility Reserve in Children Undergoing Dialysis by Dobutamine Stress Echocardiography

Pediatric Cardiology — Wed, 19 May 2010 11:17:57 +0100

Abstract Left ventricular hypertrophy is an adaptive mechanism in children undergoing chronic dialysis to improve contractility at rest. The aim of this study was to determine the left ventricular performance and contractility reserve by “dobutamine stress echocardiography” in children undergoing chronic dialysis. Thirty-five children undergoing dialysis and 24 healthy subjects were enrolled in this prospective study. We evaluated contractility by means of end-systolic wall stress—velocity of circumferential fiber shortening (VCFc) in 24 healthy subjects and 35 dialysis patients. Dobutamine stress echocardiography was obtained only in children undergoing dialysis. Patients were divided into two groups according to left ventricular mass index. Contractile reserve was ...

Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children

European Journal of Pediatrics — Sat, 15 May 2010 08:03:20 +0100

Abstract Obesity is associated with a number of risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension, and early atherosclerosis. Evidence indicates that atherosclerosis begins in childhood and progresses over decades. In this work, we examined the relationship between cardiovascular risk factors and ultrasonographic signs of subclinical atherosclerosis in 77 obese children and adolescents compared to 40 non-obese healthy peers. Carotis intima media thickness (cIMT), carotid artery compliance (CAC), brachial artery flow-mediated dilatation (FMD), and established cardiovascular risk factors were studied. In the obese patients, cIMT was significantly increased (0.57 mm vs 0.45 mm, p < 0.001) whereas CAC (1.84% vs 3.29%, p < 0.001) and FM...

Abstract Published on Initial Results From XOMA 052 Clinical Trial in Behcet's Disease

Medical News (via PRIMEZONE) — Wed, 12 May 2010 18:38:00 +0100

BERKELEY, Calif., May 12, 2010 (GLOBE NEWSWIRE) -- XOMA Ltd. (Nasdaq:XOMA), a leader in the discovery and development of therapeutic antibodies, announced the publication of an abstract titled, "Safe, Rapid-onset and Sustained Biological Activity of IL-1 beta Regulating Antibody XOMA 052 in Resistant Uveitis of Behcet's Disease: Preliminary Results of a Pilot Trial." Uveitis of Behcet's disease is an auto-inflammatory condition that can result in blindness or partial vision loss as described below. The abstract will be presented June 17, 2010 during the annual European Congress of Rheumatology in Rome, Italy by Professor Ahmet Gul, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University, Turkey, and principal investigator for this XOMA 0...

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Natural killer cells control a T helper 1 response in patients with Behcet's disease

BioMed Central — Mon, 10 May 2010 23:00:00 +0100

Conclusions: NK cells may control disease flare/remission in BD patients via NK type 2-mediated modulation of the Th1 response. (Source: BioMed Central)

STAT4 polymorphism in a Chinese Han Population with Vogt-Koyanagi-Harada syndrome and Behcet's disease.

Human Immunology — Thu, 29 Apr 2010 23:00:00 +0100

Authors: Hu K, Yang P, Jiang Z, Hou S, Du L, Li F The study was to investigate the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLP) in 379 VKH patients, 366 BD patients and 414 controls. The 20% of the samples were sequenced to validate PCR-RFLP result. A binary logistic regression analysis was used to assess the influence of the gender on the association of STAT4 polymorphism with BD. A significantly increased frequency of TT genotype of the STAT4 rs7574865 was observed in VKH patients (p=0.013). GT genotypic frequency was significantly lowe...

Association between matrix metalloproteinase 9 promoter polymorphisms and Behcet's disease.

Human Immunology — Wed, 31 Mar 2010 23:00:00 +0100

Authors: Lee YJ, Kang SW, Baek HJ, Choi HJ, Bae YD, Kang EH, Lee EY, Lee EB, Song YW Matrix metalloproteinases (MMP)-9 expression is reported to be upregulated in several primary vasculitides. -1562 C>T and -91 [CA](n) repeats polymorphisms can affect MMP-9 promoter activity. We investigated the distributions of these functional polymorphisms in 122 patients with Behçet's disease (BD) and in 122 gender- and age-matched healthy controls. Plasma levels of MMP-9 were analyzed. The frequency of "L" alleles with [CA](n) < 21 was significantly lower in all BD patients (versus controls, odds ratio (OR)=0.371 [95% confidence interval 0.152-0.905]) and male patients (versus male controls, OR=0.117 [0.019-0.737]). Furthermore, the frequency of "H/H" homozygote with [CA](n) >/= 21 w...

Behcet’s disease: from east to west

Clinical Rheumatology — Wed, 31 Mar 2010 05:42:57 +0100

Abstract Behcet's disease (BD) is classified among vasculitides. There are actually five nationwide surveys of BD: Iran, Japan, China, Korea, and Germany. Among case series, four are on more than 200 cases (Turkey, Morocco, Tunisia, and UK). BD was classically seen around the Silk Route. Now, it is seen everywhere. The male to female ratios were, respectively (in nationwide surveys), 1.19, 0.98, 1.34, 0.63, and 1.40 to 1. The mean age at onset was 26.2, 35.7, 33.8, 29, and 26 years. Major manifestations were seen, respectively, in nationwide surveys: mucous membrane (oral aphthosis in 97%, 98%, 98%, 99%, and 98%; genital aphthosis in 65%, 73%, 76%, 83%, and 64%); skin manifestations (pseudo-folliculitis in 57%, N/A, 31%, N/A, and 62%; erythema nodosum in 22%, N/A, 38%...

Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review

Clinical and Molecular Allergy — Thu, 25 Mar 2010 00:00:00 +0100

We describe 6 patients presenting with recurrent inflammatory and/or infectious skin conditions who also demonstrated severely low MBL levels. One patient also had a defect in the MASP2 gene. Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient. Five patients presented recurrent pustular skin infections (cellulitis, folliculitis and cutaneous abscess). A case of Grovers disease and one forme fruste of Behcet's syndrome (orogenital ulcers) were also observed. The patients responded to antimicrobial therapy, although in some, recurrence of infection was the rule. It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease. The mechanisms may relate...

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Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review

Clinical and Molecular Allergy — Thu, 25 Mar 2010 00:00:00 +0100

We describe 6 patients presenting with recurrent inflammatory and/or infectious skin conditions who also demonstrated severely low MBL levels. One patient also had a defect in the MASP2 gene. Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient. Five patients presented recurrent pustular skin infections (cellulitis, folliculitis and cutaneous abscess). A case of Grover's disease and one forme fruste of Behcet's syndrome (orogenital ulcers) were also observed. The patients responded to antimicrobial therapy, although in some, recurrence of infection was the rule. It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease. The mechanisms may relate ...

TNF Polymorphisms in Patients with Behçet Disease: A Meta-analysis

Archives of Medical Research — Thu, 25 Mar 2010 00:00:00 +0100

Conclusions: Behcet's disease was associated with the −1031C, −238A and the −857T promoter polymorphisms in various ethnic groups. (Source: Archives of Medical Research)

Genetics of Behcet disease inside and outside the MHC

Annals of the Rheumatic Diseases — Wed, 17 Mar 2010 14:45:59 +0100

Conclusions This GWAS highlights the premier genetic susceptibility locus for BD as the major histocompatibility complex itself, wherein reside two independent loci: HLA-B and HLA-A. (Source: Annals of the Rheumatic Diseases)

Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behcet disease

British Journal of Ophthalmology — Tue, 09 Mar 2010 12:49:02 +0100

Conclusion During the initial 6 months of treatment, infliximab proved to be more effective in reducing acute episodes of uveitis in Behçet disease. (Source: British Journal of Ophthalmology)

Treat early and embrace the evidence in favour of anti-TNF-{alpha} therapy for Behcet's uveitis

British Journal of Ophthalmology — Tue, 09 Mar 2010 12:49:01 +0100

(Source: British Journal of Ophthalmology)

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Proteomic surveillance of autoantigens in patients with Behcet's disease by a proteomic approach

Microbiology and Immunology — Mon, 08 Mar 2010 00:00:00 +0100

To promote an understanding of autoimmunity in BD, we surveyed autoAgs in patients with BD and investigated the prevalence and clinical significance of the identified autoAbs. Specifically, proteins, extracted from peripheral blood mononuclear cells and separated by 2DE, were subjected to WB, using five serum samples from patients with BD. The detected candidate autoAgs were identified by mass spectrometry. As a result, 17 autoantigenic spots were detected by the 2DE-WB, out of which eight spots were identified. They are enolase-1, cofilin-1, vimentin, Rho-GDI [beta] protein, tubulin-like protein, and actin-like proteins. The autoAbs to one of the identified proteins, cofilin-1, were investigated by WB using a recombinant protein in 30 patients with BD, 35 patients with RA, 32 patients wit...

How to deal with Behcet's disease in daily practice

APLAR Journal of Rheumatology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion: Behcet's disease is a systemic disease characterized by mucocutaneous, ocular, vascular and neurologic manifestations, progressing by attacks and remissions. (Source: APLAR Journal of Rheumatology)

Tacrolimus: Nephrotoxicity in a renal transplant recipient with Behcet's disease: case report

Reactions — Mon, 01 Mar 2010 14:50:10 +0100

(Source: Reactions)

Multiple cardiovascular complications in a patient with Behcet disease.

Chinese Medical Journal — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Liu J, Zheng J, Cui L, Xu XR PMID: 20368103 [PubMed - in process] (Source: Chinese Medical Journal)

Effect of intraperitoneal erythropoietin on the degree of mucosal damage of left colon flaps in rats

Pediatric Surgery International — Wed, 24 Feb 2010 06:48:13 +0100

Conclusions This study suggests that a colon flap attached tautly to the abdominal side wall simulates colon transposition techniques and also shows that intraperitoneal EPO markedly decreases flap damage in rats with prepared colon flaps. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2584-7Authors Erdal Turk, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyIrfan Karaca, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyAytac Karkiner, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyHüseyin Evciler, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyRagip Ortac, Dr. Behcet Uz Children’s Hospital Department of Path...

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Endocardial Fibroelastosis of the Right Ventricle and Tricuspid Valve in a Young Adult with Behcet's Disease

Journal of Cardiac Surgery — Tue, 23 Feb 2010 00:00:00 +0100

In this report, we present the case of a 20-year-old man with Behcet's disease and endocardial fibroelastosis of the right ventricle involving tricuspid valve resulting in a tumor mass that was resected along with tricuspid valve replacement. The clinical and pathological features of this rare entity are reviewed. (J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)

Behcet's disease

QJM — Tue, 16 Feb 2010 14:01:12 +0100

(Source: QJM)

Nicotine-patch therapy on mucocutaneous lesions of Behcet's disease: a case series

Rheumatology — Thu, 11 Feb 2010 12:45:03 +0100

Conclusions. Mucocutaneous lesions associated with BD may be modulated by smoking. Both smoking and nicotine-replacement therapy may be efficacious not only on oral aphthae, but also on other mucocutaneous manifestations, whereas the efficacy in the treatment and prevention of other systemic manifestations of BD is not proven. At least in ex-smokers, nicotine in its pure form is well tolerated and its use could be justified in selected cases of BD with predominant and recurrent refractory mucocutaneous manifestations. (Source: Rheumatology)

Pulmonary and Vascular Manifestations of Behcet Disease: Imaging Findings

American Journal of Roentgenology — Thu, 21 Jan 2010 20:14:22 +0100

CONCLUSION. CT is a valuable imaging technique in the diagnostic work-up of Behçet disease. CT effectively demonstrates vascular system involvement that is the main cause of mortality in these patients. CT is also effective in detecting mediastinal, pleural, and pulmonary parenchymal findings related to the disease. (Source: American Journal of Roentgenology)