MedWorm: Behcet's Disease

Genetics of Behcet disease inside and outside the MHC

Annals of the Rheumatic Diseases — Wed, 17 Mar 2010 14:45:59 +0100

Conclusions This GWAS highlights the premier genetic susceptibility locus for BD as the major histocompatibility complex itself, wherein reside two independent loci: HLA-B and HLA-A. (Source: Annals of the Rheumatic Diseases)

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Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behcet disease

British Journal of Ophthalmology — Tue, 09 Mar 2010 12:49:02 +0100

Conclusion During the initial 6 months of treatment, infliximab proved to be more effective in reducing acute episodes of uveitis in Behçet disease. (Source: British Journal of Ophthalmology)

Treat early and embrace the evidence in favour of anti-TNF-{alpha} therapy for Behcet's uveitis

British Journal of Ophthalmology — Tue, 09 Mar 2010 12:49:01 +0100

(Source: British Journal of Ophthalmology)

How to deal with Behcet's disease in daily practice

APLAR Journal of Rheumatology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion: Behcet's disease is a systemic disease characterized by mucocutaneous, ocular, vascular and neurologic manifestations, progressing by attacks and remissions. (Source: APLAR Journal of Rheumatology)

Tacrolimus: Nephrotoxicity in a renal transplant recipient with Behcet's disease: case report

Reactions — Mon, 01 Mar 2010 14:50:10 +0100

(Source: Reactions)

Effect of intraperitoneal erythropoietin on the degree of mucosal damage of left colon flaps in rats

Pediatric Surgery International — Wed, 24 Feb 2010 06:48:13 +0100

Conclusions This study suggests that a colon flap attached tautly to the abdominal side wall simulates colon transposition techniques and also shows that intraperitoneal EPO markedly decreases flap damage in rats with prepared colon flaps. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2584-7Authors Erdal Turk, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyIrfan Karaca, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyAytac Karkiner, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyHüseyin Evciler, Dr. Behcet Uz Children’s Hospital Department of Pediatric Surgery Izmir TurkeyRagip Ortac, Dr. Behcet Uz Children’s Hospital Department of Path...

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Endocardial Fibroelastosis of the Right Ventricle and Tricuspid Valve in a Young Adult with Behcet's Disease

Journal of Cardiac Surgery — Tue, 23 Feb 2010 00:00:00 +0100

In this report, we present the case of a 20-year-old man with Behcet's disease and endocardial fibroelastosis of the right ventricle involving tricuspid valve resulting in a tumor mass that was resected along with tricuspid valve replacement. The clinical and pathological features of this rare entity are reviewed. (J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)

Behcet's disease

QJM — Tue, 16 Feb 2010 14:01:12 +0100

(Source: QJM)

Nicotine-patch therapy on mucocutaneous lesions of Behcet's disease: a case series

Rheumatology — Thu, 11 Feb 2010 12:45:03 +0100

Conclusions. Mucocutaneous lesions associated with BD may be modulated by smoking. Both smoking and nicotine-replacement therapy may be efficacious not only on oral aphthae, but also on other mucocutaneous manifestations, whereas the efficacy in the treatment and prevention of other systemic manifestations of BD is not proven. At least in ex-smokers, nicotine in its pure form is well tolerated and its use could be justified in selected cases of BD with predominant and recurrent refractory mucocutaneous manifestations. (Source: Rheumatology)

Pulmonary and Vascular Manifestations of Behcet Disease: Imaging Findings

American Journal of Roentgenology — Thu, 21 Jan 2010 20:14:22 +0100

CONCLUSION. CT is a valuable imaging technique in the diagnostic work-up of Behçet disease. CT effectively demonstrates vascular system involvement that is the main cause of mortality in these patients. CT is also effective in detecting mediastinal, pleural, and pulmonary parenchymal findings related to the disease. (Source: American Journal of Roentgenology)

Multiple perforations along the transverse colon as a rare presentation of intestinal behcet's disease: a case report

Clinics — Wed, 20 Jan 2010 14:47:34 +0100

The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer. (Source: Clinics)

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Celiac Artery Aneurysm Repair in Behcet Disease Complicated by Recurrent Thoracoabdominal Aortic Aneurysms

Vascular and Endovascular Surgery — Wed, 20 Jan 2010 12:05:08 +0100

Behçet’s disease is a chronic, relapsing multisystemic inflammatory disorder characterized by recurrent orogenital aphthous ulcers, uveitis, and skin lesions. Vascular involvement occurs in up to 38% of these patients. Herein, we report a 19-year-old male who initially presented with an isolated celiac artery aneurysm that was treated with open surgical repair. The patient was subsequently diagnosed with Behçet’s disease after the development of oral aphthous ulcers and multiple recurrent postoperative deep venous thromboses and thoracoabdominal arterial aneurysms. Ultimately, a hybrid approach was undertaken. This is the fifth celiac artery aneurysm ever reported in this patient group and the first to present with an isolated celiac artery aneurysm as the initial...

A Case Of Neuro-Behcet Disease Mimicking Gliomatosis Cerebri [LETTERS]

American Journal of Neuroradiology — Thu, 14 Jan 2010 16:02:10 +0100

(Source: American Journal of Neuroradiology)

Aortitis With Severe Aortic Regurgitation in Behcet's Disease: A Case Report.

J Formos Med Assoc — Fri, 01 Jan 2010 00:00:00 +0100

We report a 24-year old woman who was noted initially to have aortitis and severe aortic regurgitation caused by Behcets disease. After receiving aortic valve replacement, aortoplasty and immunosuppressant therapy, her condition became stationary. As far as we are aware, she is the youngest case that has undergone surgery. The early onset of hemodynamic decompensation is considered to be related to delay in diagnosis and lack of steroid treatment. PMID: 20123590 [PubMed - in process] (Source: J Formos Med Assoc)

Current approach in the diagnosis and management of panuveitis

Indian Journal of Ophthalmology — Tue, 22 Dec 2009 14:48:24 +0100

Bansal Reema, Gupta Vishali, Gupta AmodIndian Journal of Ophthalmology 2010 58(1):45-54Panuveitis is a generalized inflammation of not only the whole of the uveal tract but also involves the retina and vitreous humor. It differs from other anatomical sites of inflammation in terms of causes as well as distribution. The common causes of panuveitis in our population are tuberculosis, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, Behcet's disease and sarcoidosis. A large number of cases still remain idiopathic. A stepwise approach is essential while evaluating these patients to be able to identify and treat the disease timely and correctly. Ancillary tests can be appropriately applied once the anatomic site of inflammation is identified. An exhaustive approach comprising a ful...

The effects of Nigella sativa on bile duct ligation induced-liver injury in rats

Cell Biochemistry and Function — Tue, 22 Dec 2009 00:00:00 +0100

Nigella sativa (NS) has been shown to have antioxidant and antiinflammatory activities in different conditions. The goal of this study was to evaluate the effects of NS on cholestatic liver injury in rats. Thirty rats were recruited in the study as follows: Group 1, Bile duct ligation (BDL) (n = 10); Group 2, BDL plus NS (n = 10); and Group 3, Sham (n = 10). Bile duct ligated group received 0.2 mL kg-1 dose of NS intraperitoneally daily throughout 14 days. Liver damage and cholestasis were determined by the biochemical and the pathologic examination. Data showed a decrease in gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities of the NS treated rats when compared with BDL ...

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Hughes-Stovin Syndrome

Revista Brasileira de Reumatologia — Mon, 21 Dec 2009 15:17:47 +0100

A síndrome de Hughes-Stovin é uma condição rara, de causa desconhecida, caracterizada pela associação de múltiplos aneurismas de artéria pulmonar e trombose venosa profunda. Alguns autores consideram tal entidade como uma forma incompleta de apresentação da doença de Behçet, devido à semelhança entre os achados radiológicos e anatomopatológicos do comprometimento pulmonar. Os autores relatam um caso de síndrome de Hughes-Stovin cujo primeiro evento trombótico venoso antecedeu em cinco anos o aparecimento dos aneurismas pulmonares.Hughes-Stovin syndrome is a rare disorder of unknown etiology characterized by the association of multiple pulmonary artery aneurysms and deep venous thrombosis. Some authors consider this entity an incomplete form of Behcet's disease due to the ...

A diagnosis not to be missed: Behcet's disease as a cause of dilated cardiomyopathy in a young Arab male patient

APLAR Journal of Rheumatology — Mon, 14 Dec 2009 00:00:00 +0100

We report a 33-year-old Arab male patient who was thought to have severe idiopathic dilated cardiomyopathy (DCM) associated with complete atrioventricular block for more than 6 years, then was found to possess features suggestive of underlying Behcet's disease in the form of recurrent oral and genital ulcers, cutaneous folliculitis, superficial thrombophlebitis, pathergism, partially thrombosed portal vein and a positive human leukocyte antigen -B51. (Source: APLAR Journal of Rheumatology)

Mucosally induced Immunological Tolerance, Regulatory T Cells and the Adjuvant Effect by Cholera Toxin B Subunit

Scandinavian Journal of Immunology — Fri, 11 Dec 2009 13:37:33 +0100

Induction of peripheral immunological tolerance by mucosal administration of selected antigens (Ags) ('oral tolerance') is an attractive, yet medically little developed, approach to prevent or treat selected autoimmune or allergic disorders. A highly effective way to maximize oral tolerance induction for immunotherapeutic purposes is to administer the relevant Ag together with, and preferably linked to the non-toxic B subunit protein of cholera toxin (CTB). Oral, nasal or sublingual administration of such Ag/CTB conjugates or gene fusion proteins have been found to induce tolerance with superior efficiency compared with administration of Ag alone, including the suppression of various autoimmune disorders and allergies in animal models. In a proof-of-concept clinical trial in patients with ...

Prognosis of Behcet's syndrome among men with mucocutaneous involvement at disease onset: long-term outcome of patients enrolled in a controlled trial

Rheumatology — Mon, 07 Dec 2009 14:42:34 +0100

Conclusions. Being free of major organ involvement during the early years of BS does not indicate a mild prognosis for men developing BS at young age. Whether colchicine will reduce the need for immunosuppressive use among men developing BS at old age awaits formal studies. (Source: Rheumatology)

Microalbuminuria as an early marker of renal involvement in Behcet's disease: it is associated with neurological involvement and duration of the disease

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

Background Despite its nature as a systemic vasculitis, renal involvement is known to occur infrequently in Behçet's Disease (BD).Objectives Our aim was to investigate proteinuria, microhematuria and microalbuminuria in 24-h urine and evaluate subclinical or symptomatic renal involvement in BD patients.Methods Two hundred and eleven patients who fulfilled the International Behçet's Disease criteria were included in the study. After urine analysis, five of 12 patients who were found to have proteinuria underwent renal biopsy, while 199 patients without proteinuria were investigated for microalbuminuria (MA).Results A total of 34 (16.1%) patients were found to have renal involvement including 22 (11.1%) with MA and 12 with proteinuria (5.6%). Renal biopsies resulted as focal glomeruloscler...

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Peripheral ulcerative keratitis: an unusual primary ocular manifestation in Behcet's disease?

Rheumatology — Mon, 16 Nov 2009 16:00:32 +0100

(Source: Rheumatology)

Celiac disease, Behcet, and idiopathic thrombocytopenic purpura in siblings of a patient with multiple sclerosis

Multiple Sclerosis — Fri, 06 Nov 2009 14:57:07 +0100

We report a 30-year-old woman with MS, the product of consanguineous marriage, and three siblings with three different autoimmune diseases: idiopathic thrombocytopenic purpura, celiac disease, and Behçet’s disease. (Source: Multiple Sclerosis)

Neuro-Behcet's disease presenting with amnesia and frontal dysfunction

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

We report a 48-year-old patient with neuro-Behcet's disease who presented with the combination of severe memory impairment and frontal/executive dysfunction. The clinical feature mimicked that of diencephalic amnesic syndrome. The MRI and SPECT findings supported the notion that the thalamus and related subcortical–frontal connection was responsible for this patient's problem. (Source: Clinical Neurology and Neurosurgery)

Percutaneous treatment of a giant right coronary artery pseudoaneurysm in Adamantiades-Behcet's syndrome

European Heart Journal — Sun, 01 Nov 2009 07:07:06 +0100

(Source: European Heart Journal)

Etiopathogenesis of Behcet disease.

Autoimmunity Reviews — Thu, 29 Oct 2009 00:00:00 +0100

Authors: Mendoza-Pinto C, García-Carrasco M, Jiménez-Hernández M, Hernández CJ, Riebeling-Navarro C, Zavala AN, Recabarren MV, Espinosa G, Quezada JJ, Cervera R Bechet disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes, skin, joints, etc., which produce various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown, although immunological abnormalities, possibly induced by susceptible microbiological pathogens, have been postulated. PMID: 19879978 [PubMed - as supplied by publisher] (Source: Autoimmunity Reviews)

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Drug usage evaluation of dapsone

Indian Journal of Pharmaceutical Sciences — Wed, 28 Oct 2009 14:05:17 +0100

Kannan G, Vasantha J, Rani N Vanitha, Thennarasu P, Kousalya K, Anuradha P, Reddy C UmaMaheswaraIndian Journal of Pharmaceutical Sciences 2009 71(4):456-460Dapsone has been the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. It is also widely used by dermatologists in varied skin conditions like dermatitis herpetiformis, bullous pemphigoid, Behcet's disease, lupus erythematous and a host of other skin diseases. Hence an attempt has been made to review the utilization and qualitative evaluation of dapsone over a period of 6 months in a tertiary care teaching hospital. The study consisted of 80 patients (54 leprosy and 26 non-leprosy patients), prescribed with dapsone 100 mg oral once daily. The prescribing patterns of d...

Necrotizing vasculitis - a 2009 update.

Bulletin of the NYU Hospital for Joint Diseases — Wed, 28 Oct 2009 11:20:08 +0100

Authors: Sharaf PH, Yazici Y Necrotizing vasculitis continues to be a condition where difficult diagnostic and treatment decisions need to be made, with only a few well-done studies as clinical reference and support. New data suggest that both methotrexate and azathioprine may be effective agents for maintaining remission in antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis after remission is achieved with cyclophosphamide-based therapies. In addition, Behcet's syndrome appears to be more common than previously assumed and is likely more common than a combination of ANCA-associated vasculitis (AAV) syndromes. PMID: 19852754 [PubMed - in process] (Source: Bulletin of the NYU Hospital for Joint Diseases)

Low prevalence of juvenile-onset Behcet's disease with uveitis in East/South Asian people

British Journal of Ophthalmology — Fri, 23 Oct 2009 17:24:45 +0100

Conclusions: Behçet’s disease with uveitis was less common in children than in adults in East/South Asia. Although the clinical features of the systemic disease were similar in children and adults, there was a lower frequency of genital ulceration in children. (Source: British Journal of Ophthalmology)

Behcet Extracranial Carotid Aneurysms: Is There Still a Role for Ligation?

European Journal of Vascular and Endovascular Surgery — Wed, 21 Oct 2009 00:00:00 +0100

Conclusion: Surgical repair in Behcet ECAAs should be performed with special precautions in order to prevent anastomotic pseudoaneurysm formation. Ligation can be performed when the anatomical and/or pathological circumstances are not favourable, provided that the stump pressure is adequate to maintain cerebral perfusion. (Source: European Journal of Vascular and Endovascular Surgery)

Behcet Extracranial Carotid Aneurysms: Is There Still a Role for Ligation?

PubMed: Eur J Vasc Endovasc ... — Sun, 18 Oct 2009 23:00:00 +0100

CONCLUSION: Surgical repair in Behcet ECAAs should be performed with special precautions in order to prevent anastomotic pseudoaneurysm formation. Ligation can be performed when the anatomical and/or pathological circumstances are not favourable, provided that the stump pressure is adequate to maintain cerebral perfusion. PMID: 19846323 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)

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Patient Characteristics in Behcet Disease: A Retrospective Analysis of 213 Turkish Patients during 20014

American Journal of Clinical Dermatology — Fri, 16 Oct 2009 13:00:23 +0100

(Source: American Journal of Clinical Dermatology)

Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians

Rheumatology — Fri, 16 Oct 2009 06:06:47 +0100

Conclusions. Of the three CD-associated single nucleotide polymorphisms, one of the variant NOD2 alleles, was found to be present significantly less in Caucasian BD patients. (Source: Rheumatology)

Low-dose natural human interferon-{alpha} lozenges in the treatment of Behcet's syndrome

Rheumatology — Fri, 16 Oct 2009 06:06:47 +0100

Conclusions. Low-dose natural human IFN- did not have beneficial effects on reducing the total ulcer burden among BS patients from Turkey. The study also showed that counting the number of ulcers rather than measuring the size would be adequate in future studies. Trial registration. ClinicalTrials.gov, NCT00483184, http://www.clinicaltrials.gov/ct2/results?term=NCT00483184 (Source: Rheumatology)

Comparison of argon laser photocoagulation-induced cutaneous inflammation and skin pathergy test in Behçet’s disease

Clinical Rheumatology — Sun, 11 Oct 2009 07:24:31 +0100

This study aims to investigate the argon laser photocoagulation (ALP)-induced cutaneous inflammation in BD patients and controls and also to compare the results with the skin pathergy test (SPT). The study group consisted of 35 patients with BD and 28 healthy volunteers. The ALP was applied to the left forearms of all cases from 20-cm distance (2,000 mW, 100 µm) with exposure times ranging from 0.2 to 0.7 s with 0.1-s increments. Also, a SPT with three prics was performed to both forearms of all cases. The ALP-induced cutaneous inflammation and SPT were evaluated and scored with the same method at 48 h, and the SPR scores of 2+ and above was accepted as positive. Positive results as defined above were found in eight cases (23%) with the ALP and in nine (26%) with...

Aortic valve replacement in Behcet's disease: surgical modification to prevent valve detachment [How-to-do-it]

European Journal of Cardio-Thoracic Surgery — Tue, 29 Sep 2009 23:00:00 +0100

Aortic valve replacement (AVR) for aortic regurgitation due to Behcet's disease is often complicated with valve detachment. In our institute, between 1981 and 2006, five consecutive patients with aortic regurgitation secondary to Behcet's disease underwent valve detachment after initial surgery. A novel modification of AVR termed ‘subannular ring reinforcement technique’ was introduced to prevent valve detachment. We performed AVR with this new manoeuvre in three patients. No prosthetic valve detachment was noted after a mean period of 3 ± 1.8 years (range: 1.5–5.1 years). In this technique, we put a ring-shaped prosthetic graft in subannular position and sandwiched the aortic valve annulus between the prosthetic valve and graft with vertical mattress sutures. We c...

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No association of CTLA-4 polymorphisms with susceptibility to Behcet disease [Original articles]

British Journal of Ophthalmology — Thu, 24 Sep 2009 17:05:50 +0100

Conclusion: This study and a meta-analysis failed to demonstrate any association between the tested CTLA-4 polymorphisms and BD. (Source: British Journal of Ophthalmology)

Basic parameters of thrombophilia in ocular Behcet disease with posterior segment involvement [Original articles]

British Journal of Ophthalmology — Thu, 24 Sep 2009 17:05:50 +0100

Conclusion: Activated protein C resistance together with increased antithrombin III plasma levels are associated with the posterior segment involvement in ocular BD based on the assessment of basic thrombophilic tests. (Source: British Journal of Ophthalmology)

[Original articles] No association of CTLA-4 polymorphisms with susceptibility to Behcet disease

British Journal of Ophthalmology — Wed, 23 Sep 2009 23:00:00 +0100

Conclusion: This study and a meta-analysis failed to demonstrate any association between the tested CTLA-4 polymorphisms and BD. (Source: British Journal of Ophthalmology)

[Original articles] Basic parameters of thrombophilia in ocular Behcet disease with posterior segment involvement

British Journal of Ophthalmology — Wed, 23 Sep 2009 23:00:00 +0100

Monocyte chemoattractant protein (MCP)-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with Ocular Behcet's disease.

Human Immunology — Wed, 23 Sep 2009 23:00:00 +0100

In conclusion, the present study suggests that the MCP-1 -2518 AA genotype seems to display a protective association with ocular BD, whereas the -2518 AG genotype might be a susceptible factor to ocular BD in Chinese Han population. PMID: 19782713 [PubMed - as supplied by publisher] (Source: Human Immunology)

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Aortic Elastic Properties of Patients with Neurocardiogenic Syncope

Pacing and Clinical Electrophysiology : PACE — Mon, 21 Sep 2009 23:00:00 +0100

Conclusions: Findings of this study have shown that elastic properties of aorta are impaired in patients with NCS. The data suggest that increase in aortic stiffness might be one of the determinants responsible for NCS. This proposal of novel link should be confirmed in further studies. (PACE 2009; 1[ndash]5) (Source: Pacing and Clinical Electrophysiology : PACE)

Elevated levels of serum antibodies against Saccharomyces cerevisiae mannan in patients with systemic lupus erythematosus.

Lupus — Sat, 19 Sep 2009 13:34:03 +0100

This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMAs), a serological marker for Crohn's disease, seronegative spondyloarthritis and Behcet's disease, also correlate with systemic lupus erythematosus (SLE) in humans. Serum samples from healthy volunteers (n = 152) and patients with SLE (n = 40) were compared for ASCMA-IgA, -IgG and -IgM levels using enzyme linked immunosorbent assays. ASCMA-IgG, but not IgM and IgA, prevalence was significantly raised in active SLE patients (57.5%) compared with healthy controls (8.5%). ASCMA-IgG levels in SLE patients during remission were relatively lower, indicating a possible correlation with disease activity. These results differ from a previous study, which did not detect a difference betwe...

The imaging spectrum of neuro-Behcet disease

Neurology — Sun, 13 Sep 2009 23:00:00 +0100

(Source: Neurology)

Management of Behcet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behcet disease [Clinical and epidemiological research]

Annals of the Rheumatic Diseases — Fri, 11 Sep 2009 17:03:02 +0100

Conclusion: Properly designed, controlled studies (new and confirmatory) are still needed to guide us in managing BD. (Source: Annals of the Rheumatic Diseases)

[Clinical and epidemiological research] Management of Behcet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behcet disease

Annals of the Rheumatic Diseases — Thu, 10 Sep 2009 23:00:00 +0100

Conclusion: Properly designed, controlled studies (new and confirmatory) are still needed to guide us in managing BD. (Source: Annals of the Rheumatic Diseases)

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When the diagnosis is a zebra: pulmonary artery aneurysm.

Connecticut Medicine — Mon, 31 Aug 2009 23:00:00 +0100

We describe a case of a patient who presented to our institution with recurrent hemoptysis. The clinical features were suggestive of an underlying infection or malignancy. When these were ruled out, the search for a zebra had begun. The patient underwent sixty four-slice computerizedtomographic angiography (CTA) which revealed a right pulmonary artery aneurysm (PAA). Timely involvement of interventional radiologists and thoracic surgeons prevented a potentiallylife-threatenninghemorrhage. This case underlines the importance of awareness of this condition in the formulation of a differential diagnosis forhemoptysis. PAAis a rare condition that is either congenital or acquired. Common acquired etiologies include chronic thromboembolic pulmonary hypertension, infections (syphilis and tubercul...

Cytokines in the colon of a patient with Behcet's disease

Arthritis Research and Therapy — Wed, 26 Aug 2009 23:00:00 +0100

We present data of Th-1 and Th17 cytokines in the gut of a patient with therapy refractory Behcet's disease and relate those to the findings of Canete et al in a recent publication in Arthritis Res & Ther. (Source: Arthritis Research and Therapy)

Incomplete (atypical) Kawasaki disease in a young infant with remarkable paucity of signs

Rheumatology International — Wed, 19 Aug 2009 08:27:06 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00296-009-1099-9Authors Murat Muhtar Yilmazer, Behcet Uz Children’s Hospital Department of Pediatric Cardiology Alsancak 35210 Izmir TurkeyTimur Mese, Behcet Uz Children’s Hospital Department of Pediatric Cardiology Alsancak 35210 Izmir TurkeySavaş Demirpençe, Behcet Uz Children’s Hospital Department of Pediatric Cardiology Alsancak 35210 Izmir TurkeyVedide Tavli, Yeditepe University Department of Pediatrics, Faculty of Medicine Istanbul TurkeyIlker Devrim, Behcet Uz Children’s Hospital Department of Pediatrics Izmir TurkeyBarış Guven, Behcet Uz Children’s Hospital Department of Pediatric Cardiology Alsancak 35210 Izmir TurkeyTaliha Öner, Behcet Uz Children’s Hospital Department of Pediatric Cardiolo...

Comparison of infliximab versus cyclosporine during the initial 6-month treatment period in Behcet's disease.

The British Journal of Ophthalmology — Mon, 17 Aug 2009 23:00:00 +0100

CONCLUSION: During the initial 6 months of treatment, infliximab proved to be more effective in reducing acute episodes of uveitis in Behçet's disease. PMID: 19692382 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Generalized Sweet Syndrome Lesions Associated with Behcet Disease: A True Association or Simply Co-Morbidity?

American Journal of Clinical Dermatology — Mon, 10 Aug 2009 10:17:52 +0100

(Source: American Journal of Clinical Dermatology)

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Low prevalence of juvenile-onset Behcet's diease with uveitis in East/South Asian people.

The British Journal of Ophthalmology — Sat, 08 Aug 2009 23:00:00 +0100

CONCLUSIONS: Behcet's disease with uveitis was less common in children than in adults in East/South Asia. Although the clinical features of the systemic disease were similar between children and adults, there was a lower frequency of genital ulceration in children. PMID: 19666928 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

A Limbic Encephalitis MR Imaging in a Patient with Behcet Disease and Relapsing Polychondritis [LETTERS]

American Journal of Neuroradiology — Thu, 06 Aug 2009 23:00:00 +0100

(Source: American Journal of Neuroradiology)

The relationship between disease activity and depression in patients with Behcet disease and rheumatoid arthritis

Rheumatology International — Wed, 05 Aug 2009 18:28:49 +0100

Abstract Disease activity may be questioned as a possible related factor to depression in patients with rheumatoid arthritis (RA) and Behcet disease (BD). Our aims were to determine and compare the depression levels of patients with RA and BD and to investigate a possible association between disease activity and depression scores of the patients. A total of 30 RA and 30 BD patients were included in this study. In RA patients; pain, morning stiffness duration, systemic involvement, tender–swollen joints, the physician–patient global assessments and DAS28 scores were determined. In patients with BD, the BD Current Activity Form was assessed for disease activity. Beck depression inventory (BDI) was used for the evaluation of patient groups. BDI score above 13 was consider...

Novel genetic analysis in Behcet's disease

Arthritis Research and Therapy — Tue, 04 Aug 2009 23:00:00 +0100

Error, like straws, upon the surface flowHe who would search for pearls must dive belowJohn Dryden, 1678Behcet's disease (BD) is characterised by oral and genital ulceration and complicated by eye, skin, joint and CNS lesions. It has long been understood that BD has a strong genetic component, however to date the identified genes account for only around 30% of the risk of developing the disease, and the work has mostly been based on candidate gene analysis. In the a recent paper Fei et al present the results of the first genome wide analysis (GWAS) of patients with BD. These findings suggest new pathways for investigation in this complex disease. (Source: Arthritis Research and Therapy)

Recurrent acute myocardial infarction with coronary artery aneurysm in a patient with Behcet's disease: a case report

Journal of Medical Case Reports — Sun, 02 Aug 2009 23:00:00 +0100

Conclusion: This case highlights the importance of careful diagnostic work-up in the evaluation of myocardial infarction in patients. In our patient, Behcet's disease proved to be the cause of recurrent myocardial infarction. (Source: Journal of Medical Case Reports)

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A case of neuro-Behcet's disease presenting with lumbar spinal cord involvement

Spinal Cord — Tue, 28 Jul 2009 23:00:00 +0100

Authors: B Zhao, L He & X-H Lai (Source: Spinal Cord)

Basic parameters of thrombophilia in ocular behcet's disease with posterior segment involvement.

The British Journal of Ophthalmology — Sat, 25 Jul 2009 23:00:00 +0100

CONCLUSION: Activated protein C resistance together with increased antithrombin III plasma levels are associated with the posterior segment involvement in ocular BD based on the assessment of basic thrombophilic tests. PMID: 19635722 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Single episode of Behcet's disease-like symptoms caused by herpes simplex virus reactivation

Pediatrics International — Wed, 22 Jul 2009 23:00:00 +0100

(Source: Pediatrics International)

A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis

Journal of Oral Pathology and Medicine — Tue, 14 Jul 2009 23:00:00 +0100

Conclusions: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS. (Source: Journal of Oral Pathology and Medicine)

Effects of anti-TNF-{alpha} antibody infliximab in refractory entero-Behcet's disease

Rheumatology — Sat, 11 Jul 2009 23:00:00 +0100

(Source: Rheumatology)

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Renal involvement in behcet's disease.

Saudi Journal of Kidney Diseases and Transplantation — Tue, 30 Jun 2009 23:00:00 +0100

In conclusion, renal involvement in BD is not infrequent, although in most cases it is mild in nature and may be missed. PMID: 19587503 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)

[Lesion in the basal ganglia and brain stem compatible with neuro-Behcet's disease.]

Revista de Neurologia — Tue, 30 Jun 2009 23:00:00 +0100

Authors: Gonzalez-Oria C, Espinosa-Rosso R PMID: 19598142 [PubMed - in process] (Source: Revista de Neurologia)

[Dejerine-Roussy syndrome of an ischaemic origin in an adolescent with patent foramen ovale.]

Revista de Neurologia — Sat, 27 Jun 2009 17:47:29 +0100

CONCLUSIONS. This is the first reported case of Dejerine-Roussy syndrome as a manifestation of cryptogenic cerebral infarction associated to patent foramen ovale in an adolescent. Taken as a whole, the clinical and complementary data enable us to reconstruct the pathophysiological sequence that position foramen ovale with an associated septal 'aneurysm' as the only detectable risk factor, which, when linked to the stress of the patient and the family, triggered its early closure. PMID: 19557696 [PubMed - in process] (Source: Revista de Neurologia)

CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease

Tissue Antigens — Wed, 24 Jun 2009 23:00:00 +0100

Cytotoxic T lymphocyte antigen 4 (CTLA4; CD152) is a costimulatory molecule expressed on activated T cells that plays a key inhibitory role during T lymphocyte activation. The gene encoding for CTLA4 has been suggested as a candidate for conferring susceptibility to autoinflammatory diseases. We investigated the polymorphisms of the CTLA4 gene [promoter region ([minus]1722 T/C, [minus]1661 A/G and [minus]318 C/T) and exon 1 (+49 G/A)] and the differences of serum soluble sCTLA4 levels in 285 patients with Behcet's disease (BD) and 287 controls. The frequency of the CTLA4 [minus]1661 GG genotype was significantly higher in BD patients than in controls [P = 0.019, odds ratio (OR) = 5.2, 95% confidence interval (CI) = 1.13[ndash]23.86]. Also, the genotype frequency for CTLA4 [minus]1722 TC wa...

Behçet's disease and vitiligo in two brothers: coincidence or association?

Clinical And Experimental Dermatology — Sun, 21 Jun 2009 23:00:00 +0100

We report on two brothers with ocular Behcet's disease who had advanced unilateral ophthalmic symptoms associated with vitiligo. The two brothers had recurrent oral and genital ulceration, uveitis and white patches on their skin. The most probable hypothesis for the aetiology of BD is that of an autoimmune reaction in genetically predisposed individuals, with vasculitis as the main pathological hallmark. Despite many years of research, the specific causes of vitiligo remain obscure, and the most advanced aetiological hypothesis remains that of autoimmunity. To our knowledge, this is the first reported case within the literature of BD associated with vitiligo. The existence of the two different disorders is noteworthy as they were observed in two brothers during the same period in their liv...

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Bilateral intraocular inflammation after intravitreal bevacizumab in Behcet's disease

Eye — Thu, 18 Jun 2009 23:00:00 +0100

Authors: J H Bae & S C Lee (Source: Eye)

Bilateral intraocular inflammation after intravitreal bevacizumab in Behcet's disease

Eye — Thu, 18 Jun 2009 23:00:00 +0100

Authors: J H Bae & S C Lee (Source: Eye)

Is there any relationship between serum and urine neopterin and serum interferon-γ levels in the activity of Behcet's disease?

Journal of the European Academy of Dermatology and Venereology — Mon, 15 Jun 2009 04:00:00 +0100

Conclusions We conclude that serum and urinary neopterin measurement can not be used as a reliable laboratory marker as the BD patients' serum and urinary neopterin levels do not increase in the active stage even though these levels increase when compared to healthy controls. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

[Editor's quiz] Epigastric pain in a woman with previous Behcet's disease

Gut — Thu, 11 Jun 2009 04:00:00 +0100

(Source: Gut)

Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

Mediators of Inflammation — Wed, 10 Jun 2009 02:35:10 +0100

Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation. (Source: Mediators of Inflammation)

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Vitiligo Koebnerized by Behcet Disease Genital Ulceration

American Journal of Clinical Dermatology — Sun, 07 Jun 2009 18:15:01 +0100

(Source: American Journal of Clinical Dermatology)

Efficacy of oral tacrolimus on intestinal Behcet's disease

Inflammatory Bowel Diseases — Fri, 05 Jun 2009 04:00:00 +0100

No abstract. (Source: Inflammatory Bowel Diseases)

Diverse phenotypic and genotypic presentation of RAG1 mutations in two cases with SCID

Clinical and Experimental Medicine — Thu, 21 May 2009 06:10:55 +0100

Abstract Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T−B−NK+SCID. Amorphic mutations in RAG1 and RAG2 cause T−B−NK+SCID, whereas hypomorphic mutations cause an immunodeficency characterized by oligoclonal expansion of TCRγδ T cells, severe CMV infection and autoimmunity. First patient is a typical T−B−NK+SCID with clinical and immunologic findings while the second is atypical with normal immunoglobulin levels, CD4 lymphopenia, elevated TCRγδ T cells, persistent CMV infection, and autoimmune...

[ORIGINAL ARTICLES: ADULT CARDIAC] Long-Term Experience of Surgical Treatment for Aortic Regurgitation Attributable to Behcet's Disease

The Annals of Thoracic Surgery — Thu, 21 May 2009 04:00:00 +0100

Conclusions The mortality in this condition was very high and was found to depend on levels of postoperative inflammatory markers. Aortic root replacement and postoperative immunosuppressive therapy may be helpful. (Source: The Annals of Thoracic Surgery)

Long-Term Experience of Surgical Treatment for Aortic Regurgitation Attributable to Behcet's Disease [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Wed, 20 May 2009 23:00:00 +0100

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Identification of novel genetic susceptibility loci for Behcet's disease using a genome-wide association study

Arthritis Research and Therapy — Thu, 14 May 2009 04:00:00 +0100

Conclusions: Utilizing an unbiased whole-genome genetic association approach, we identified novel candidate genetic loci that are associated with increased susceptibility for Behcet's disease. These findings will help to better understand the pathogenesis of Behcet's disease and identify novel targets for therapeutic intervention. (Source: Arthritis Research and Therapy)

Association of TLR4 polymorphisms with Behcet's disease in a Korean population

Rheumatology — Wed, 13 May 2009 04:00:00 +0100

Conclusions. The haplotype of TLR4 may increase the risk for developing BD and the complication of arthritis in the Korean population. (Source: Rheumatology)

[Reviews] Nicotine: does it have a role in the treatment of skin disease?

Postgraduate Medical Journal — Tue, 05 May 2009 04:00:00 +0100

Epidemiological evidence suggests that, although smoking is detrimental in some skin diseases, it is of benefit in others such as pemphigus and Behcet disease. Evidence that nicotine is of therapeutic value in selected skin diseases is limited to case reports. There has been renewed interest in nicotinic acetylcholine receptor agonists, such as nicotine, after the discovery of a "nicotinic anti-inflammatory pathway". Nicotinic acetylcholine receptors exist in abundance in human skin, but it is unknown whether they exert an anti-inflammatory effect. Randomised controlled trials of nicotine preparations in those skin conditions that occur less often in smokers are necessary to establish the value of nicotine, if any, in the treatment of skin disease. (Source: Postgraduate Medical Journal)

Acute Myocardial Infarction in a Patient with Behçet's Disease.

Archives of Iranian Medicine — Thu, 30 Apr 2009 23:00:00 +0100

Acute Myocardial Infarction in a Patient with Behçet's Disease. Arch Iran Med. 2009 May;12(3):313-6 Authors: Beyranvand MR, Namazi MH, Mohsenzadeh Y, Assadpour Piranfar M A 37-year-old man, a known case of Behcet's disease with its vascular complications such as abdominal and thoracic artery aneurysms, was admitted with the diagnosis of acute anterior myocardial infarction and received thrombolytic therapy. Coronary angiography and percutaneous coronary intervention via transradial approach were performed for the patient on the eighth day of admission. The patient did not suffer from any symptoms, myocardial infarction, or readmission in the nine-month follow-up. About 25 cases of myocardial infarction associated with Behcet's disease have been reported previously. Althoug...

Vasculitides of the gastrointestinal tract

Seminars in Diagnostic Pathology — Thu, 30 Apr 2009 23:00:00 +0100

Systemic vasculitis is often not considered as a possible diagnosis by clinicians because of its low prevalence compared with other more common diseases. Vasculitis can affect any end organ, and it is therefore often missed early on in disease progression. Gastrointestinal (GI) manifestations of vasculitis are considered rare and the presentation is often nonspecific. However, if there is significant involvement of the major vessels of the gastrointestinal system, life-threatening sequelae, including perforation and bowel ischemia, may occur. This makes early and immediate management crucial to improve long-term morbidity and mortality. Diagnosis of various GI vasculitides often relies on correlation of clinical manifestations with pathology and additional investigations. This paper review...

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Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet's disease?

Arthritis Research and Therapy — Thu, 30 Apr 2009 04:00:00 +0100

Behcet's disease is a complex vasculitis of unknown etiology. Abundant neutrophils suggest innate immunity involvement. Cytokines are skewed to the Th1-pattern. Few sterile organs are easily accessible for analysis in Behcet's disease. Canete et al. show inflamed joints as a feasible model and suggest involvement of innate immunity in Behcet's disease. (Source: Arthritis Research and Therapy)

Epidemiology and clinical characteristics of behçet's disease in the US: A population-based study

Arthritis Care and Research — Wed, 29 Apr 2009 04:00:00 +0100

Behçet's disease (BD) is a rare, multisystem inflammatory disorder of unknown cause. Although well-documented in Eastern populations, epidemiologic data is scarce in North American countries. Here we describe the incidence and prevalence of BD in Olmsted County, Minnesota over 45 years.We identified an incidence cohort of subjects age [ge]18 years who had a clinical diagnosis of and/or fulfilled the International Study Group (ISG) criteria for BD from January 1, 1960 to January 1, 2005. Age- and sex-specific incidence and prevalence were estimated and age- and sex-adjusted to the 2000 US total population.The study population was comprised of 13 subjects with BD; 11 fulfilled ISG criteria between 1960 and 2005. Mean ± SD age was 31 ± 9 years, and 69% were white. Point prevalence in 2000 ...

A histopathological approach: when papulopustular lesions should be in the diagnostic criteria of Behçet's disease?

Journal of the European Academy of Dermatology and Venereology — Wed, 29 Apr 2009 04:00:00 +0100

Conclusions We evaluated more patients than previous related studies reported in the literature. Histopathological findings of vasculitis were encountered only in BD group. Non-vasculitis histopathological findings were also encountered in the control group patients. In conclusion, PPL can be used as a diagnostic criterion of BD subsequent to finding vasculitis in histopathological examination of the biopsy specimen of the PPL. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

[CORRESPONDENCE] Behcet's Inflammatory Vessels for Cannulation in Inflammatory Aortic Repair

The Annals of Thoracic Surgery — Tue, 21 Apr 2009 04:00:00 +0100

(Source: The Annals of Thoracic Surgery)

Behcet's Inflammatory Vessels for Cannulation in Inflammatory Aortic Repair [CORRESPONDENCE]

The Annals of Thoracic Surgery — Mon, 20 Apr 2009 23:00:00 +0100

(Source: The Annals of Thoracic Surgery)

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Long-lasting Remission of Severe Behcet's Disease After the End of Infliximab Therapy.

J Rheumatol — Wed, 01 Apr 2009 04:00:00 +0100

Authors: Olivieri I, Padula A, Leccese P, D'Angelo S, Giasi V PMID: 19342728 [PubMed - in process] (Source: J Rheumatol)

Hemoptysis and Behcet's Syndrome.

J Rheumatol — Wed, 01 Apr 2009 04:00:00 +0100

Authors: Peall AF, Jones SM PMID: 19342723 [PubMed - in process] (Source: J Rheumatol)

Cerebral venous thrombosis in Behçet's disease

Arthritis Care and Research — Mon, 30 Mar 2009 04:00:00 +0100

We reported a series of 64 consecutive patients with CVT who fulfilled the international criteria for BD. Multivariate analysis was performed to define factors that affect prognosis.Among a cohort of 820 patients with BD, CVT was present in 64 (7.8%). Compared with BD patients without CVT, those with CVT had lower parenchymal central nervous system involvement (4.7% versus 28.7%; P = 0.0001) and higher extraneurologic vascular lesions (62.5% versus 38.8%; P = 0.03). Up to 90% of patients responded to anticoagulation therapy without severe hemorrhagic complications. Neither steroid nor immunosuppressant use provided better outcome. Severe visual loss due to optic atrophy was the main complication of CVT, being found in 15% of patients. In multivariate analysis, papilledema (odds ratio [OR] ...

Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-α level in patients with mucocutaneous type of Behcet's disease

Journal of Oral Pathology and Medicine — Thu, 26 Mar 2009 04:00:00 +0100

Conclusions: Treatment with levamisole and colchicine can result in a significant reduction of serum IL-6, IL-8 or TNF-[alpha] level in MCBD patients. (Source: Journal of Oral Pathology and Medicine)

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis

Rheumatology — Mon, 16 Mar 2009 04:00:00 +0100

Conclusions. IL-6 is responsible for causing ocular inflammation, and it is, at least partially, due to IL-6-dependent Th17 differentiation. IL-6 may be a target for therapy of refractory endogenous uveitis in humans. (Source: Rheumatology)

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Premenarchal Vulvar Ulceration: Is Chronic Irritation a Causative Factor?

Pediatric Dermatology — Wed, 11 Mar 2009 04:00:00 +0100

Conclusion: Girls with vulvar ulcerations who have deny being sexually active should be thoroughly evaluated for infections, Behcet's disease, and other health problems, but, in addition, should be questioned about use of tight-fitting clothing in the perineal area. We hypothesize that chronic irritation because of tight clothing may play a role in causing vulvar ulcerations in this setting. (Source: Pediatric Dermatology)

The close association between dental and periodontal treatments and oral ulcer course in behcet's disease: a prospective clinical study

Journal of Oral Pathology and Medicine — Fri, 06 Mar 2009 05:00:00 +0100

Conclusion: Our results suggest that, in BD patients, dental and periodontal therapies could be associated with a flare-up of oral ulcers in the short term, but may decrease their number in longer follow-up. They also lead to a better oral health. (Source: Journal of Oral Pathology and Medicine)

Triamcinolone: Pathergy-like reaction following intravitreal injection in a patient with Behcet's disease: case report.

Reactions Weekly — Mon, 02 Mar 2009 17:37:33 +0100

Page: 39 (Source: Reactions Weekly)

Ciclosporin: Increased parenchymal neurological involvement in patients with Behcet's disease: 8 case reports.

Reactions Weekly — Mon, 02 Mar 2009 17:37:32 +0100

Page: 15 (Source: Reactions Weekly)

Ciclosporin: Increased parenchymal neurological involvement in patients with Behcet's disease: 8 case reports

Reactions — Mon, 02 Mar 2009 16:18:41 +0100

(Source: Reactions)

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Triamcinolone: Pathergy-like reaction following intravitreal injection in a patient with Behcet's disease: case report

Reactions — Mon, 02 Mar 2009 16:18:41 +0100

(Source: Reactions)

Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet's disease

Journal of Oral Pathology and Medicine — Mon, 02 Mar 2009 05:00:00 +0100

Conclusions: Oral QoL was similar in patients from UK and Turkey with active oral ulcers. However, the number of oral ulcers was observed to be higher in UK. As expected, a lower utilization rate of dental services might have led to a poorer oral health in patients from Turkey. J Oral Pathol Med (2009) (Source: Journal of Oral Pathology and Medicine)

PROCALCITONIN MIGHT HELP IN DISCRIMINATION BETWEEN MENINGEAL NEURO-BEHcET DISEASE AND BACTERIAL MENINGITIS

Neurology — Mon, 23 Feb 2009 05:00:00 +0100

(Source: Neurology)

Significance of serum interleukin-8 levels in patients with Behcet's disease: high levels may indicate vascular involvement

International Journal of Dermatology — Thu, 19 Feb 2009 05:00:00 +0100

Conclusion Serum IL-8 levels are increased in the active phase of BD. This marker may be useful in the early detection of vascular involvement. (Source: International Journal of Dermatology)

[Case report - Thoracic non-oncologic] Successful surgical treatment of pulmonary artery aneurysm in Behcet's syndrome

Interactive CardioVascular and Thoracic Surgery — Tue, 17 Feb 2009 05:00:00 +0100

We report herein an uncommon clinical case of pulmonary artery aneurysm in Behçet's syndrome, for which only a few reports have been published in the literature to date. A 68-year-old Japanese male, who was referred for recurrent fever of unknown origin, anemia and pulmonary nodular opacities, was treated by right lower lobectomy followed by postoperative oral administration of colchicine and corticosteroid. Postoperative pathological examination confirmed a diagnosis of pulmonary artery aneurysm accompanied by vasculitis and thrombi. Clinical and radiographic feature are presented herein. (Source: Interactive CardioVascular and Thoracic Surgery)

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[eComment] eComment: Treatment of pulmonary artery aneurysm in Behcet's disease - few things can make big differences

Interactive CardioVascular and Thoracic Surgery — Tue, 17 Feb 2009 05:00:00 +0100

(Source: Interactive CardioVascular and Thoracic Surgery)

OBSERVATION: Antiphosphatidylserine-Prothrombin Complex Antibodies in 3 Patients With Behcet Disease Involving Superficial Vein Thrombophlebitis

Archives of Dermatology — Mon, 16 Feb 2009 05:00:00 +0100

Conclusions A high titer of IgM antiphosphatidylserine-prothrombin complex Abs was found in our patients with Behçet disease involving superficial vein thrombophlebitis. We speculate that there is a relationship between the antiphospholipid Abs, especially IgM antiphosphatidylserine-prothrombin complex Abs, and superficial vein thrombophlebitis complications in Behçet disease. This study suggests that elevated serum antiphosphatidylserine-prothrombin complex Ab levels might play some role in the development of the vascular manifestations in Behçet disease. (Source: Archives of Dermatology)

Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behcet's disease.

Journal of Medical Microbiology — Sat, 14 Feb 2009 08:18:02 +0100

We present a case of Mycobacterium kansasii olecranon bursitis in a woman with known immunosuppression secondary to the treatment received for her Behçet's disease. We found only one other case report of olecranon bursitis caused by M. kansasii in the literature, which, unlike our case, presented in an immunocompetent adult following trauma. This case extends the range of opportunistic mycobacterial infections that are associated with anti-tumour necrosis factor therapy. PMID: 19208889 [PubMed - in process] (Source: Journal of Medical Microbiology)

Distinct synovial immunopathology in Behcet disease and psoriatic arthritis

Arthritis Research and Therapy — Fri, 06 Feb 2009 05:00:00 +0100

Conclusions: This systematic comparative analysis of early, untreated synovitis identifies neutrophils and T lymphocytes as important infiltrating cell populations in Behcet disease. Increased levels of perforin in Behcet disease suggest the relevance of cytotoxicity in this disease. (Source: Arthritis Research and Therapy)

Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

Mediators of Inflammation — Mon, 02 Feb 2009 16:01:36 +0100

Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation. (Source: Mediators of Inflammation)

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[Serial Episodes of Gastric and Cecal Perforation in a Patient with Behcet's Disease Involving the Whole Gastrointestinal Tract: A Case Report.]

Korean J Gastroenter... — Sun, 01 Feb 2009 05:00:00 +0100

Authors: Shin DY, Cheon JH, Park JJ, Kim H, Kim TI, Lee YC, Kim NK, Kim WH Behcet's disease (BD) has been recognized as multi-systemic chronic vasculitic disorder of recurrent inflammation, characterized by the involvement of multiple organs and resulting in orogenital ulcers, uveitis, and skin lesions. Involvement of the central nervous system, vessels, and intestines in BD often leads to a poor prognosis. Digestive manifestations in BD have been reported in up to 1-60% of cases, although the rate varies in different countries. The most frequent extra-oral sites of gastrointestinal involvement are the ileocecal region and the colon. Gastric or esophageal involvement is reported to be very rare. Moreover, there have been no reports on the simultaneous involvement of the esophagus, stom...

The metabolic etiology of urolithiasis in Turkish children

International Urology and Nephrology — Sat, 31 Jan 2009 07:44:23 +0100

Abstract Pediatric urolithiasis is an endemic disease, especially in certain developing regions of the world, such as the Far East, and to a certain extent the Middle East and Turkey. The aim of the study is to determine the metabolic etiology and the prevalence of formation of urinary calculi in Turkish pediatric patients with urolithiasis. Seventy-two pediatric patients diagnosed as having urolithiasis were studied from 1999–2005 in Dr. Behcet Uz Child Disease and Surgery Education and Research Hospital Nephrology Department, Izmir, according to their presenting signs and clinical and laboratory findings. The other necessary tests were also applied to detect the etiology of the calculi formation. Of the 72 patients, 50 (69.4%) were male and 22 (30.6%) were female, with...

Hughes-Stovin Syndrome: a case report and review of the literature

Cases Journal — Thu, 29 Jan 2009 05:00:00 +0100

Conclusion: In young men presenting with venous thrombosis as revealed on imaging examination, with platelet count and coagulation tests within normal and hemoptysis the eventuality of Hughes-Stovin syndrome is to be considered. (Source: Cases Journal)

Cryptococcal meningitis in a patient treated with infliximab and mycophenolate mofetil for Behcet's disease

International Journal of Infectious Diseases — Wed, 21 Jan 2009 00:00:00 +0100

A 46-year-old Caucasian male was admitted in June 2007 for a recent history of headaches and fever. He had been treated for Behçet's disease for the past seven years, with recurrent oral aphtosis, diffuse arthralgias and severe uveitis. Unusual severe bilateral uveitis prompted us to give oral corticosteroids for 30 months, infliximab for 18 months and mycophenolate mofetil (2g/day) for 14 months. Infliximab was started in January 2006 at a dose of 3mg/kg/infusion (250mg) and then 5mg/kg/infusion (400mg) in January 2007. The patient had received his nineteenth infusion 15 days before admission. (Source: International Journal of Infectious Diseases)

Cryptococcal meningitis in a patient treated with infliximab and mycophenolate mofetil for Behcet's disease.

International Journal of Infectious Diseases — Mon, 19 Jan 2009 05:00:00 +0100

Authors: Kluger N, Poirier P, Guilpain P, Baixench MT, Cohen P, Paugam A PMID: 19157948 [PubMed - as supplied by publisher] (Source: International Journal of Infectious Diseases)

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Spectrum of non-inflammatory bowel disease and non-infectious colitis.

World Journal of Gastroenterology : WJG — Fri, 26 Dec 2008 17:31:05 +0100

Authors: Koutroubakis IE A variety of inflammatory diseases of the colon, which can be differentiated from inflammatory bowel disease (IBD) and infectious colitis by their clinical, endoscopic and histological characteristics, are reported as non-IBD and non-infectious colitis. These diseases include microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis. The etiopathogenesis of most of these diseases remains obscure and the epidemiological data are rather limited. These conditions are often troublesome for the patient and are associated with diagnostic difficulties for the physician. In many cases the treatment is empirical and there is a need for future research using random...

Orogenital ulcers in a liver transplant recipient: discerning between mycophenolate-mofetil-induced complication and Behcet's disease

Clinical Transplantation — Mon, 22 Dec 2008 05:00:00 +0100

(Source: Clinical Transplantation)

[Original articles - Clinical science] Clinical and demographic evaluation of Behcet disease among different paediatric age groups

British Journal of Ophthalmology — Fri, 19 Dec 2008 05:00:00 +0100

Conclusion: Patient age appeared to define the type of ocular involvement in BD. While anterior uveitis was the most frequent ocular finding in BD patients younger than 10 years, panuveitis was the most frequent in patients older than 10 years. As a family history of BD was more frequent among patients younger than 10 years, family screening for BD is considered critical for early and accurate diagnosis of BD, as well as for the control of its complications. (Source: British Journal of Ophthalmology)

[Original articles - Clinical science] Clinical and demographic evaluation of Behcet disease among different paediatric age groups

British Journal of Ophthalmology — Fri, 19 Dec 2008 05:00:00 +0100

Differentiation of Behcet's disease from inflammatory bowel diseases: Anti-saccharomyces cerevisiae antibody and anti-neutrophilic cytoplasmic antibody.

World Journal of Gastroenterology — Thu, 18 Dec 2008 06:07:20 +0100

Authors: Filik L, Biyikoglu I The differential diagnosis of Behcet's disease (BD) from inflammatory bowel disease (IBD) is sometimes difficult and challenging. Hereby, we suggested the utility of anti-saccharomyces cerevisiae antibody (ASCA) and anti-neutrophilic cytoplasmic antibody (p-ANCA) in the differential diagnosis of BD from IBD. PMID: 19084948 [PubMed - in process] (Source: World Journal of Gastroenterology)

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Interleukin-6 small interfering RNA improved the herpes simplex virus-induced systemic inflammation in vivo Behcet’s disease-like mouse model

Gene Therapy — Thu, 18 Dec 2008 05:00:00 +0100

Interleukin-6 small interfering RNA improved the herpes simplex virus-induced systemic inflammation in vivo Behcet’s disease-like mouse model Gene Therapy advance online publication, December 18, 2008. doi:10.1038/gt.2008.180 Authors: J Shim, H O Byun, Y D Lee, E S Lee & S Sohn (Source: Gene Therapy)

Familial risks for amyotrophic lateral sclerosis and autoimmune diseases

Neurogenetics — Wed, 17 Dec 2008 08:04:04 +0100

Abstract Population-level familial risks are not available for amyotrophic lateral sclerosis (ALS), and a few studies have analyzed familial association of ALS with other diseases. We used the Swedish Multigeneration Register to identify family members and link them to the Hospital Discharge Register to calculate standardized incidence ratios (SIRs) for familial association in ALS and 33 autoimmune diseases. Among 4,970 ALS patients, familial SIR for offspring of affected parents was 4.71, for singleton siblings, it was 29.83, and for members of multiplex families, it was 1,100; 1.1% of the offspring had an affected parent, and 2.2% an affected sibling. The high risks among siblings without affected parents may suggest recessive inheritance. The SIR for spouse correlation ...

Pulmonary alveolar proteinosis in a patient with Behcet's disease

Respirology — Tue, 16 Dec 2008 05:00:00 +0100

Secondary pulmonary alveolar proteinosis (PAP) has been described in several clinical settings that can be grouped into three main categories: infections of the lung; haematological malignancies and other conditions that alter the patient's immune status; and exposure to inhaled chemicals and minerals. Recent studies reported that anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody was present in the serum of patients with idiopathic PAP but not in patients with secondary PAP or in normal subjects. The present report describes the interesting case of a patient with Behcet's disease and PAP. The absence of anti-GM-CSF antibodies in this patient suggested a diagnosis of secondary PAP. (Source: Respirology)

Identification of measles virus epitopes using an ultra-fast method of panning phage-displayed random peptide libraries.

Journal of Virological Methods — Mon, 15 Dec 2008 05:00:00 +0100

Authors: Yu X, Barmina O, Burgoon M, Gilden D Phage-displayed random peptide libraries, in which high affinity phage peptides are enriched by repetitive selection (panning) on target antibody, provide a unique tool for identifying antigen specificity. This paper describes a new panning method that enables selection of peptides in 1 day as compared to about 6 days required in traditional panning to identify virus-specific epitopes. The method, termed ultra-fast selection of peptide (UFSP), utilizes phage produced by bacterial infection (phage amplification) directly for subsequent panning. Phage amplified in less than 1h of infection in Escherichia coli are used for binding to target antibody pre-coated in the same wells of an ELISA plate, obviating the need for traditional large-scale ...

Resolution of Behcet's disease after non-myeloablative allogeneic stem cell transplant for acute myeloid leukaemia

Rheumatology — Thu, 04 Dec 2008 05:00:00 +0100

(Source: Rheumatology)

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[Neurological manifestations of Behcet's disease: 22 cases among 170 patients.]

Presse Medicale — Wed, 03 Dec 2008 05:00:00 +0100

CONCLUSION: Within central neurological involvement in Behçet's disease, we can individualize 4 clinical aspects: meningoencephalitis (and/or myelitis), brainstem syndrome, tumor-like features and cerebral venous thrombosis. Abnormalities, observed on CT Scan and MRI, by their brainstem localization and their multiplicity, should evoke the diagnosis. Corticosteroids, when prescribed early, are useful and are associated with better prognosis; their association to immunosuppressant agents should be considered in the parenchymatous forms. PMID: 19062244 [PubMed - as supplied by publisher] (Source: Presse Medicale)

Medical panel

Behcet's Syndrome Society: Medical — Sun, 30 Nov 2008 15:09:29 +0100

Introductions to the members of the BSS Medical Panel (Source: Behcet's Syndrome Society: Medical)

Medical panel

Behcet's Syndrome Society: Medical — Sun, 30 Nov 2008 15:09:29 +0100

Introductions to the members of the BSS Medical Panel (Source: Behcet's Syndrome Society: Medical)

Comment on "Cardiac Behcet Disease Presenting as Aortic Valvulitis/Aortitis or Right Heart Inflammatory Mass: A Clinicopathologic Study of 12 Cases".

The American Journal of Surgical Pathology — Thu, 27 Nov 2008 09:22:58 +0100

Page: 1914DOI: 10.1097/PAS.0b013e31818479e4Authors: Hamuryudan, Vedat MD; Seyahi, Emire MD; Yazici, Hasan MD (Source: The American Journal of Surgical Pathology)

Ethnogeographic Variation of Behcet Disease Presentation and Necessity for Diagnostic Criteria Modification.

The American Journal of Surgical Pathology — Thu, 27 Nov 2008 09:22:58 +0100

Page: 1915DOI: 10.1097/PAS.0b013e31818479f6Authors: Lee, Inchul MD, PhD *; Yoo, Bin MD, PhD +; Song, Jae-Kwan MD, PhD + (Source: The American Journal of Surgical Pathology)

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It's Not So Sweet

Medscape Rheumatology Headlines — Wed, 26 Nov 2008 15:20:32 +0100

This case study of Behcet's disease offers a brief overview of this uncommon and serious condition. What does a nurse need to know? Journal of Pediatric Health Care (Source: Medscape Rheumatology Headlines)

Colonic perforation in Behcet's syndrome.

World Journal of Gastroenterology — Fri, 14 Nov 2008 05:00:00 +0100

This report describes an unusual complication of Behcets syndrome occurring at the time of presentation and a review of the current literature of reported cases. PMID: 19030217 [PubMed - in process] (Source: World Journal of Gastroenterology)

[Recommendation] EULAR recommendations for the management of Behcet disease

Annals of the Rheumatic Diseases — Wed, 12 Nov 2008 05:00:00 +0100

Conclusion: Recommendations related to the eye, skin–mucosa disease and arthritis are mainly evidence based, but recommendations on vascular disease, neurological and gastrointestinal involvement are based largely on expert opinion and uncontrolled evidence from open trials and observational studies. The need for further properly designed controlled clinical trials is apparent. (Source: Annals of the Rheumatic Diseases)

Imiquimod: Activation of genital Behcet's disease ulcers: case report

Reactions — Tue, 11 Nov 2008 07:48:41 +0100

(Source: Reactions)

Imiquimod: Activation of genital Behcet's disease ulcers: case report.

Reactions Weekly — Sat, 08 Nov 2008 10:55:33 +0100

Page: 16 (Source: Reactions Weekly)

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Prevalence of Celiac Disease Among Patients with Behcet’s Disease in Iran

Digestive Diseases and Sciences — Fri, 07 Nov 2008 08:20:20 +0100

Conclusion Our findings didn’t support any association between celiac disease and Behcet’s disease in Iranian patients compared to the general population of Iran. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-008-0548-8Authors Farhad Zamani, Iran University of Medical Sciences Gastrointestinal and Liver Disease Research Center Tehran IranFarhad Shahram, Shariati Hospital, Tehran University of Medical Sciences Rheumatology Research Center Tehran IranRamin Shakeri, Shariati Hospital, Tehran University of Medical Sciences Digestive Disease Research Center North Kargar Ave. Tehran 14117-13135 IranHabib Zayyeni, Shariati Hospital, Tehran University of Medical Sciences Rheumatology Research Center Tehran IranFereydoun Davatchi, Shariati Hospital, Tehran Univer...

Formation of a Bronchoesophageal Fistula Following Concurrent Radiation and Chemotherapy for Lung Cancer in the Setting of Behcet's Disease.

Journal of Thoracic Oncology — Sat, 01 Nov 2008 10:19:48 +0100

Page: 1361DOI: 10.1097/JTO.0b013e31818b1af2Authors: Meyer, Jeffrey MD; Wahidi, Momen MD; Shofer, Scott MD, PhD; Evans, John MD; Crawford, Jeffrey MD; Kelsey, Chris R. MD (Source: Journal of Thoracic Oncology)

Retinal detachment due to a macular hole in a patient with Behcet disease treated with vitrectomy and silicone oil tamponade.

European Journal of Ophthalmology — Sat, 01 Nov 2008 04:00:00 +0100

CONCLUSIONS. Behçet disease could be rarely associated with retinal detachment caused by a macular hole. Macular traction caused by severe recurrent vitritis in combination with the retinochoroidal atrophy due to the relapsing retinitis might be the underlying mechanism of this complication, which to the authors' knowledge has never been reported before. PMID: 18988182 [PubMed - in process] (Source: European Journal of Ophthalmology)

The Behcet's Disease Quality of Life: Reliability and Validity of the Korean Version.

Yonsei Medical Journal — Fri, 31 Oct 2008 04:00:00 +0100

Conclusion: Adaptation of the BD-QoL for use in Korea was successful. Together with the BDCAF-K, it may be a valuable tool for assessing the influence of interventions in BD patients and outcome in clinical trials. PMID: 18972588 [PubMed - in process] (Source: Yonsei Medical Journal)

Behcet's disease

MayoClinic.com Full Feed — Thu, 30 Oct 2008 05:00:00 +0100

— Comprehensive overview covers symptoms and treatment of this inflammatory syndrome. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

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Accelerated Healing of Pyoderma Gangrenosum in Behcet Patient Treated With Cyclosporine and Split Thickness Skin Graft.

Annals of Plastic Surgery — Fri, 24 Oct 2008 11:03:48 +0100

Page: 552DOI: 10.1097/SAP.0b013e31816dd391Authors: Kim, Deok-Woo MD; Lee, Byung-Il MD, PhD; Park, Seung-Ha MD, PhD (Source: Annals of Plastic Surgery)

Clinical and demographical evaluation in pediatric behcet's disease among different age groups.

The British Journal of Ophthalmology — Fri, 24 Oct 2008 04:00:00 +0100

CONCLUSION: Patient age appeared to define the type of ocular involvement in BD. While anterior uveitis was the most frequent ocular finding in BD patients younger than 10 years, panuveitis was the most frequent in patients older than 10 years. As a family history of BD was more frequent among patients younger than 10 years, family screening for BD is considered critical for early and accurate diagnosis of BD, as well as for the control of its complications. PMID: 18952648 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Non-MS autoimmune demyelination.

Clinical Neurology and Neurosurgery — Wed, 22 Oct 2008 14:04:19 +0100

Authors: Cikes N, Bosnic D, Sentic M Connective tissue diseases can be characterised by central nervous system (CNS) involvement, in some patients manifested by demyelination areas in the white matter of the brain and spinal cord, which are difficult to differentiate from multiple sclerosis (MS) and other demyelinating processes, such as transverse myelitis and optic neuritis. Demyelinating process may be the feature of nervous impairment in systemic lupus erythematosus, Behcet's disease (BD), Sjoegren's syndrome (SS), systemic sclerosis (SSc) or very rarely other systemic autoimmune diseases. An acute isolated neurological syndrome, as the most common symptom of MS can sometimes be the only feature or even first manifestation of nervous impairment in connective tissue disease, hence p...

Cardiovascular Behcet Disease: The Variable Findings of Rare Complications With CT Angiography and Conventional Angiography and Its Interventional Management.

Journal of Computer Assisted Tomography — Fri, 03 Oct 2008 10:59:20 +0100

Page: 679DOI: 10.1097/RCT.0b013e3181573282Authors: Cho, Young Kwon MD *; Lee, Whal MD *; Choi, Sang Il MD +; Jae, Hwan Jun MD *; Chung, Jin Wook MD *; Park, Jae Hyung MD * (Source: Journal of Computer Assisted Tomography)

Visual evoked potentials in differential diagnosis of multiple sclerosis and neurobehcet's disease.

The Tohoku Journal of Experimental Medicine — Wed, 01 Oct 2008 04:00:00 +0100

In this study, to identify the parameters of electrophysiological testing that might be useful in their differential diagnosis, we performed evoked potentials (EPs) and electroneuromyography (ENMG) on patients with MS and NB, and on normal volunteers. A total of 95 persons, 55 MS patients, 20 NB patients and 20 normal volunteers between ages 31 and 55, were studied electrophysiologically. Visual evoked potential (VEP), brainstem auditory evoked potential (BAEP), posterior tibial somatosensory evoked potential (SEP) and nerve conduction and needle electromyography studies were performed on all patients and volunteers. All parameters of EPs were compared among the groups. The results of the BAEP and SEP studies did not show statistically significant difference between NB and MS. However, the...

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Triamcinolone: Pathergy-like reaction following intravitreal injection in a patient with Behcet disease?: case report

Reactions — Tue, 30 Sep 2008 11:04:42 +0100

(Source: Reactions)

Triamcinolone: Pathergy-like reaction following intravitreal injection in a patient with Behcet disease?: case report.

Reactions Weekly — Sat, 27 Sep 2008 11:13:10 +0100

Page: 29 (Source: Reactions Weekly)

MedlinePlus: Síndrome de Behcet

NLM General Announcements — Mon, 22 Sep 2008 17:23:02 +0100

(Source: NLM General Announcements)

Rebamipide affects the efficiency of colchicine for the herpes simplex virus-induced inflammation in a Behcet's disease mouse model.

European Journal of Pharmacology — Wed, 17 Sep 2008 04:00:00 +0100

Authors: Bang D, Choi B, Kwon HJ, Lee ES, Lee S, Sohn S Rebamipide inhibits free radicals derived from activated neutrophils and decreases the inhibiting inflammatory cytokine. Behcet's disease (BD) is a chronic, multi-systemic inflammatory disorder with arthritic, gastrointestinal, mucocutaneous, ocular, vascular, and central nervous system involvement. This disease has a chronic course with periodic exacerbations and progressive deterioration. To study the effect of rebamipide treatment to BD-like mice, combination treatment with rebamipide and colchicine was compared to colchicine treatment. Colchicine is one of the most frequently prescribed medicine to the patients with BD. For each BD mouse, 200 mul gastric fluid or 2 mug colchicine or 150 mug rebamipide or 2 mug colchicine plus ...

[Online Only] Radiologic and Clinical Findings of Behcet Disease: Comprehensive Review of Multisystemic Involvement

Radiographics recent issues — Mon, 15 Sep 2008 04:00:00 +0100

Behçet disease is a chronic, relapsing, systemic disorder of unknown etiology, characterized by recurrent oral and genital ulcers, uveitis, and other clinical manifestations in multiple organ systems. Although the diagnosis is made on the basis of the combination of typical clinical symptoms, radiologic findings of Behçet disease show characteristic features of its involvement in the gastrointestinal, neurologic, cardiovascular, and thoracic organ systems. In the gastrointestinal tract, Behçet disease may produce various types of ulcers in the esophagus, stomach, and small and large intestines, as well as deeply penetrating ulcerations in the ileocecal region, with frequently accompanying enteric fistulas. Neurologic involvement includes typical and atypical parenchyma...

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Increased Enthesopathy Among Behcet's Syndrome Patients With Acne and Arthritis: An Ultrasonography Study.

Ultrasound Quarterly — Sat, 06 Sep 2008 09:47:17 +0100

Page: 173DOI: 10.1097/01.RUQ.0000288131.14440.ea (Source: Ultrasound Quarterly)

Molecular analysis of MEFV gene mutations among Palestinian patients with Behcet's disease.

Scandinavian Journal of Rheumatology — Mon, 01 Sep 2008 04:00:00 +0100

CONCLUSION: This study is the first genetic analysis of MEFV mutations among Palestinian BD patients. It reflects their mutations profile, providing further data that MEFV mutations are an additional genetic susceptibility factor in BD. PMID: 18609258 [PubMed - indexed for MEDLINE] (Source: Scandinavian Journal of Rheumatology)

Behcet Disease in Children.

International Ophthalmology Clinics — Tue, 22 Jul 2008 09:11:25 +0100

Page: 87DOI: 10.1097/IIO.0b013e31817d8393Authors: Kitaichi, Nobuyoshi MD, PhD; Ohno, Shigeaki MD, PhD (Source: International Ophthalmology Clinics)

Visual Prognosis and Risk Factors for Korean Patients with Behcet Uveitis

Ophthalmologica — Thu, 17 Jul 2008 15:26:32 +0100

Ophthalmologica 2008;222:344-350 (DOI:10.1159/000146080) (Source: Ophthalmologica)