MedWorm: Brenner Tumor

Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors

Archives of Gynecology and Obstetrics — Sat, 24 Dec 2011 16:41:54 +0100

In conclusion, Brenner ovarian tumors are unilateral, small and benign neoplasms in their majority and present specific histopathological and immunopathological characteristics and mixed forms with other epithelial and germ cell neoplasms. This could be explained as a form of metaplasia or a diverse histogenesis from surface epithelium and/or the germ cell ovarian component. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-011-2182-5Authors A. Kondi-Pafiti, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceEvi Kairi-Vassilatou, Pathology Laboratory, Aretaieion University Hospital, Athens Medical School, Athens, GreeceCh. Iavazzo, 2nd Clinic of Obstetrics and Gynecology, Aretaieion University Hospit...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Epithelial Ovarian Tumors in Adolescents: A Retrospective Pathologic Study and a Critical Review of the Literature

Journal of Pediatric and Adolescent Gynecology — Mon, 26 Sep 2011 04:00:00 +0100

Conclusions: A relatively high frequency of epithelial ovarian neoplasms among all ovarian tumors in a purely adolescent population was found in our study. Age-related selection bias may account at least in part for the discrepancy between our data and most previous reports. The most common subtype of epithelial ovarian tumor in our series was the benign serous cystadenoma. (Source: Journal of Pediatric and Adolescent Gynecology)

Prediction of benignity of solid adnexal masses

Archives of Gynecology and Obstetrics — Fri, 19 Aug 2011 16:01:14 +0100

Conclusion We present a retrospective study of both surgical and nonsurgical management of solid ovarian masses. None of the sonographically diagnosed benign-appearing solid adnexal masses were subsequently proved to be malignant either at pathology or by clinical course, suggesting that ultrasound can accurately predict benignity in these masses and that conservative management is an option in these patients. Content Type Journal ArticleCategory General GynecologyPages 1-6DOI 10.1007/s00404-011-2062-zAuthors Shengfu Wang, Department of Radiology, Wayne State University School of Medicine, Detroit Medical Center, 4201 St. Antoine, DRH 3L-8, Detroit, MI 48201, USASamuel Johnson, Department of Radiology, Wayne State University School of Medicine, Detroit Medical Cent...

Malignant Brenner tumor of the ovary: analysis of 13 cases

International Journal of Clinical Oncology — Wed, 27 Jul 2011 15:51:21 +0100

Conclusion In our study, we found that diagnosis was at an advanced stage, and recurrence rate was high. The mainstay of treatment is surgical resection, but the exact regimen and benefit of adjuvant therapy remain unknown. Content Type Journal ArticlePages 1-6DOI 10.1007/s10147-011-0290-7Authors Kazım Gezginç, Department of Obstetrics and Gynecology, Selçuk University Meram Medical School, Akyokuş, 42080 Konya, TurkeyRengin Karatayli, Department of Obstetrics and Gynecology, Selçuk University Meram Medical School, Akyokuş, 42080 Konya, TurkeyFatma Yazici, Department of Obstetrics and Gynecology, Selçuk University Meram Medical School, Akyokuş, 42080 Konya, TurkeyAli Acar, Department of Obstetrics and Gynecology, Selçuk University Meram Medical School, Akyok...

Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm

Human Pathology — Sat, 18 Jun 2011 23:17:13 +0100

Summary: Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer based on a dualistic model of carcinogenesis that divides epithelial ovarian cancer into 2 broad categories designated types I and II. Type I tumors comprise low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas, and Brenner tumors. They are generally indolent, present in stage I (tumor confined to the ovary), and are characterized by specific mutations, including KRAS, BRAF, ERBB2, CTNNB1, PTEN, PIK3CA, ARID1A, and PPP2R1A, which target specific cell signaling pathways. Type I tumors rarely harbor TP53 mutations and are relatively stable genetically. Type II tumors comprise high-gra...

A singular observation of a giant benign Brenner tumor of the ovary

Archives of Gynecology and Obstetrics — Wed, 18 May 2011 18:19:07 +0100

Conclusion The largest benign Brenner tumors reported in literature have been up to 30 cm in size, and greater size has been thought to be a predictor of malignancy. We have seen, however, that it is possible for larger lesions of this type to have a completely benign behavior; consequently, a benign nature should not be excluded even in the event of a large ovarian lesion. Content Type Journal ArticlePages 1-4DOI 10.1007/s00404-011-1930-xAuthors Silvia Ruggiero, Department of Surgery, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyValter Ripetti, Department of Surgery, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyAntonella Bianchi, Department of Surgery, University Campus Bio-Medico of...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Unusual Presentation of Benign Cystic Brenner Tumor With Exuberant Psammomatous Calcifications

International Journal of Surgical Pathology — Mon, 31 Jan 2011 00:00:00 +0100

This study reports a case of benign Brenner tumor with exuberant dystrophic calcifications that obscured most of the epithelium and posed a diagnostic challenge in differentiating it from the more common malignant counterparts such as serous carcinoma and specifically psammocarcinoma. (Source: International Journal of Surgical Pathology)

Brenner Tumor Presenting as a Retrorectal Mass with Prior Hysterectomy and Salpingo-Oopherectomy

Journal of Gynecologic Surgery — Fri, 03 Dec 2010 04:43:58 +0100

Journal of Gynecologic Surgery , Vol. 0, No. 0. (Source: Journal of Gynecologic Surgery)

Primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma

Annals of Diagnostic Pathology — Mon, 11 Oct 2010 04:00:00 +0100

We present a 58-year-old woman with primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma. Noninvolved ovary showed no Brenner tumor, endometriosis, transitional carcinoma, endometrioid adenocarcinoma, or typical multigerm layer classic mature teratoma. Moreover, no other primary site was possible because there were no prior or concomitant squamous carcinomas, or history of cervical intraepithelial neoplasia. The tumor showed strong positivity for p63 and CK5/6, reactivity that also extended from the squamous carcinoma into the basal-cell lining of the mucinous cyst of a likely monodermal teratoma. This basal-cell pattern was absent in a series of conventional benign and borderline cystic mucinous cystadenomas of the ovary, but clearly present in...

A Patient With Diabetes and Breast Cancer In Whom Virilization Was Caused by a Testosterone-Producing Mature Cystic Teratoma Containing a Brenner Tumor.

The American Journal of the Medical Sciences — Sun, 03 Oct 2010 23:00:00 +0100

Authors: Tsujimoto T, Takaichi M, Endo H, Yasuda K, Kishimoto M, Noto H, Gomibuchi H, Yasuda H, Yamamoto-Honda R, Takahashi Y, Kajio H, Sasano H, Noda M A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resectio...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Incidental Adnexal Masses Detected at Low-Dose Unenhanced CT in Asymptomatic Women Age 50 and Older: Implications for Clinical Management and Ovarian Cancer Screening [Genitourinary Imaging]

Radiology — Fri, 17 Sep 2010 15:19:14 +0100

Conclusion: Incidental indeterminate adnexal lesions were relatively common at unenhanced CT (4.1%), but subsequent work-up revealed no ovarian cancers. Furthermore, a normal finding at CT was not protective against short-term development of ovarian cancer. More sophisticated risk factor assessment is needed to identify women at higher risk. © RSNA, 2010 (Source: Radiology)

A case of hypertension with virilisation during pregnancy

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Tue, 31 Aug 2010 23:00:00 +0100

This case report describes the onset of hypertension and virilisation during pregnancy due to a Brenner tumour. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Predominant Brenner Tumor Combined with Struma Ovarii Containing a Papillary Microcarcinoma Associated with Benign Peritoneal Strumosis: Report of a Case and Histologic Features

Endocrine Pathology — Mon, 07 Jun 2010 17:15:44 +0100

Abstract Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are both rare entities. Both tumors rarely become malignant and rarely metastasize. Few published reports describe coexisting Brenner tumor and malignant struma ovarii. Patients in whom these malignancies coexist only occasionally have peritoneal spreading, strumosis, or a history of thyrotoxicosis. The patient we describe, a 74-year-old woman, presented with a 2 months’ history of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass. The mass consisted predominantly of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant transformatio...

The Expression and Diagnostic Utility of p63 in the Female Genital Tract

Advances in Anatomic Pathology — Sat, 29 Aug 2009 12:32:09 +0100

p63 plays a key role in epithelial development in various organs, being expressed in myoepithelial cells and in basal cells of stratified epithelia. In the female genital tract, p63 is expressed in the basal and parabasal cells of mature cervical, vaginal and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone and in immature metaplastic and atrophic cervical squamous epithelium. In this review, the diagnostic utility of p63 immunohistochemical staining in various pathologic scenarios within the female genital tract is discussed. Cervical microglandular hyperplasia is p63 positive with a characteristic subcolumnar location due to expression in reserve cells. There is increased expression in cervical intraepithelial neoplasia, in accordance with the deg...

Brenner tumor in pregnancy: Clinical approach and pathological findings

Journal of Obstetrics and Gynaecology Research — Wed, 26 Nov 2008 05:00:00 +0100

The Brenner tumor is an uncommon ovarian tumor in pregnancy with only three previous cases in the English published reports. A 35-year-old woman delivered abdominally because of distress symptoms and a Brenner tumor was resected incidentally. Histological examination revealed a tumor composed of epithelial nests and areas of stromal luteinization. The patient was treated conservatively. Brenner tumor should be considered in the differential diagnosis of adnexal masses during pregnancy. These tumors are mainly benign and show typical luteinization associated with the hormonal milieu in pregnancy. (Source: Journal of Obstetrics and Gynaecology Research)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors.

Archives of Pathology and Laboratory Medicine — Sat, 01 Nov 2008 04:00:00 +0100

CONCLUSIONS: The strong association of mucinous and transitional cell components, similar type of calcification, complementary size distributions, and frequent identification of a transitional component in the face of an exceedingly small estimated proportion of that component suggest that this association has been underestimated. The association of Brenner tumors with Walthard nests, although significant, appears weak and not strongly supportive of a histogenetic relationship. The stronger association of Walthard nests with mucinous tumors remains unexplained. PMID: 18976011 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Malignant Brenner Tumor With Transition From Benign to Malignant Components: Computed Tomographic and Magnetic Resonance Imaging Findings With Pathological Correlation.

Journal of Computer Assisted Tomography — Wed, 30 Jul 2008 10:08:58 +0100

Page: 553DOI: 10.1097/RCT.0b013e3181506643Authors: Takeuchi, Mayumi MD, PhD *; Matsuzaki, Kenji MD, PhD *; Sano, Nobuya MD, PhD +; Furumoto, Hiroyuki MD, PhD ++; Nishitani, Hiromu MD, PhD * (Source: Journal of Computer Assisted Tomography)

[Proliferating Brenner tumor: Case report.]

Gynecologie, Obstetrique & Fertilite — Tue, 04 Mar 2008 05:00:00 +0100

Authors: Kourda N, Elloumi H, Chérif K, Jilani SB, Zermani R Brenner tumors account for only 1 to 2% of ovarian tumors. Proliferating Brenner tumors are characterized by an epithelial proliferation, resembling superficial well-differentiated urothelial carcinomas. A single 29-year-old patient was operated for an ovarian tumor. On gross examination, the tumor, which originated in the left ovary, was cystic multilocular and presented polyoid excrescences. Definitive histological exam showed a papillary proliferation lined by transitional cells without stroma infiltration. Mucinous cells lined some cavities. The diagnosis of proliferating Brenner tumor was made. Clinical and pathological characteristics of this rare entity will be discussed. PMID: 18325813 [PubMed - as supplied b...

p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas

Histopathology — Tue, 18 Sep 2007 08:43:09 +0100

Histopathology Volume 51, Issue 4, Page 477-483, Oct 2007. Liao X Y, Xue W C, Shen D H, Ngan H Y S, Siu M K & Cheung A N(2007) Histopathology 51, 477–483p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomasAims: To investigate p63 expression in ovarian neoplasms.Metho... (Source: Histopathology)

[Brenner tumour of the vagina]

Annales de Pathologie — Sat, 01 Sep 2007 04:00:00 +0100

We report a sixth case and discuss the histogenesis of this tumour, as well as the differential diagnosis with the mixed tumour of the vagina. PMID: 18185458 [PubMed - indexed for MEDLINE] (Source: Annales de Pathologie)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Transitional Cell Carcinoma of the Endometrium Associated With Benign Ovarian Brenner Tumor: A Case Report With Immunohistochemistry Molecular Analysis and a Review of the Literature.

International Journal of Gynecological Pathology — Thu, 21 Jun 2007 12:21:56 +0100

Page: 298DOI: 10.1097/01.pgp.0000236943.28969.b2Authors: Giordano, Giovanna M.D.; D'Adda, Tiziana B.Sc.D.; Gnetti, Letizia M.D.; Merisio, Carla M.D.; Raboni, Stefano M.D. (Source: International Journal of Gynecological Pathology)

Three synchronized neoplasms of the female genital tract: an extraordinary presentation

Archives of Gynecology and Obstetrics — Thu, 24 May 2007 07:23:49 +0100

We report a case of unusual co-existence of multiple primary neoplasms of female genital tract. Case A 62-year-old gravida 2, para 2 was referred with spotting and vaginal discharge for about 6 months. Fractionate curettage was performed and documented endocervical squamous cell carcinoma in situ. Subsequently total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed. Final pathological report demonstrated cervical squamous cell carcinoma, right ovarian Brenner tumor, left ovarian granulosa tumor and endometrial polyps. Discussion Multiple primary neoplasms of female genital tract is a well-recognized yet rare occurrence. Although the presented case is probably an incidental event, the pathogenesis of the neoplastic proces...

HPV induced ovarian squamous cell carcinoma: case report and review of the literature

Archives of Gynecology and Obstetrics — Fri, 02 Mar 2007 08:40:17 +0100

Conclusion??The development of bone metastases in association with an ovarian squamous cell carcinoma is a rare finding, and it did not respond to treatment with a tyrosine kinase. A review of literature is presented. Content TypeJournal Article JournalArchives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Feasibility of screening for ovarian cancer using symptoms as selection criteria.

BJOG : An International Journal of Obstetrics and Gynaecology — Mon, 01 Jan 2007 07:00:00 +0100

CONCLUSIONS: This pilot study confirms the feasibility of screening for ovarian cancer using symptoms as selection criteria. Specificity was high and patient compliance good. Initial concerns about referral volumes and additional investigations and referrals generated were not confirmed. No ovarian cancers were detected in this pilot study, and this may be due to the size of the cohort. PMID: 17233861 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

[RSNA Education Exhibits] Developing an MR Imaging Strategy for Diagnosis of Ovarian Masses

Radiographics recent issues — Thu, 14 Sep 2006 04:00:00 +0100

Magnetic resonance (MR) imaging provides useful information for characterization of various ovarian masses as neoplastic or nonneoplastic and, when neoplastic, on a spectrum from benign to malignant. The use of MR imaging for diagnosis of ovarian masses includes consideration of morphologic characteristics and signal intensity characteristics on T1- and T2-weighted images. The morphologic characteristics of cystic masses, cystic and solid masses, and predominantly solid masses provide important information. In general, cystic masses represent benign tumors, whereas cystic and solid masses are strongly associated with malignancy. Predominantly solid masses include benign, borderline malignant, and malignant tumors. T1-weighted images provide useful information for characterization because h...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Expression and subcellular localization of maspin in human ovarian epithelial neoplasms: correlation with clinicopathologic features.

J Egypt Natl Canc In... — Wed, 14 Sep 2005 06:00:00 +0100

Conclusion: Maspin was expressed in a substantial proportion of ovarian tumors with poor prognostic parameters. These results may offer new insights regarding the role of maspin in ovarian cancer that may also impact diagnosis and treatment strategies. Moreover, variation in maspin expression between Brenner tumor and other epithelial surface ovarian tumors may indicate that the different histological types probably represent distinct disease entities and involve different molecular pathways. PMID: 16799655 [PubMed - in process] (Source: J Egypt Natl Canc In...)