MedWorm: Brenner Tumor

HERA Requests Applications for Ovarian Cancer Study

ScanGrants feed — Thu, 08 Oct 2009 23:00:00 +0100

The HERA Women’s Cancer Foundation, a nationally recognized ovarian cancer nonprofit organization, has announced funding for a study focused on type I ovarian cancer; low-grade serous carcinoma, mucinous carcinoma, malignant Brenner tumor and/or clear cell carcinoma. The research will concentrate on the cause, early detection, treatment, and/or understanding of this disease.Scientists and clinicians of non-profit research, medical service and educational institutions located in the U.S are eligible and encouraged to apply. The one-year award for $100,000 will support direct costs of the project, up to 50 percent of salary support, reagents and supplies and other justifiable expenses. Indirect costs are not covered by this award.Letters of intent are due November 1, 2009. Questions a...

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The Expression and Diagnostic Utility of p63 in the Female Genital Tract

Advances in Anatomic Pathology — Sat, 29 Aug 2009 12:32:09 +0100

p63 plays a key role in epithelial development in various organs, being expressed in myoepithelial cells and in basal cells of stratified epithelia. In the female genital tract, p63 is expressed in the basal and parabasal cells of mature cervical, vaginal and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone and in immature metaplastic and atrophic cervical squamous epithelium. In this review, the diagnostic utility of p63 immunohistochemical staining in various pathologic scenarios within the female genital tract is discussed. Cervical microglandular hyperplasia is p63 positive with a characteristic subcolumnar location due to expression in reserve cells. There is increased expression in cervical intraepithelial neoplasia, in accordance with the deg...

Brenner tumor in pregnancy: Clinical approach and pathological findings

Journal of Obstetrics and Gynaecology Research — Wed, 26 Nov 2008 05:00:00 +0100

The Brenner tumor is an uncommon ovarian tumor in pregnancy with only three previous cases in the English published reports. A 35-year-old woman delivered abdominally because of distress symptoms and a Brenner tumor was resected incidentally. Histological examination revealed a tumor composed of epithelial nests and areas of stromal luteinization. The patient was treated conservatively. Brenner tumor should be considered in the differential diagnosis of adnexal masses during pregnancy. These tumors are mainly benign and show typical luteinization associated with the hormonal milieu in pregnancy. (Source: Journal of Obstetrics and Gynaecology Research)

Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors.

Archives of Pathology and Laboratory Medicine — Sat, 01 Nov 2008 04:00:00 +0100

CONCLUSIONS: The strong association of mucinous and transitional cell components, similar type of calcification, complementary size distributions, and frequent identification of a transitional component in the face of an exceedingly small estimated proportion of that component suggest that this association has been underestimated. The association of Brenner tumors with Walthard nests, although significant, appears weak and not strongly supportive of a histogenetic relationship. The stronger association of Walthard nests with mucinous tumors remains unexplained. PMID: 18976011 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Malignant Brenner Tumor With Transition From Benign to Malignant Components: Computed Tomographic and Magnetic Resonance Imaging Findings With Pathological Correlation.

Journal of Computer Assisted Tomography — Wed, 30 Jul 2008 10:08:58 +0100

Page: 553DOI: 10.1097/RCT.0b013e3181506643Authors: Takeuchi, Mayumi MD, PhD *; Matsuzaki, Kenji MD, PhD *; Sano, Nobuya MD, PhD +; Furumoto, Hiroyuki MD, PhD ++; Nishitani, Hiromu MD, PhD * (Source: Journal of Computer Assisted Tomography)

[Proliferating Brenner tumor: Case report.]

Gynecologie, Obstetrique & Fertilite — Tue, 04 Mar 2008 05:00:00 +0100

Authors: Kourda N, Elloumi H, Chérif K, Jilani SB, Zermani R Brenner tumors account for only 1 to 2% of ovarian tumors. Proliferating Brenner tumors are characterized by an epithelial proliferation, resembling superficial well-differentiated urothelial carcinomas. A single 29-year-old patient was operated for an ovarian tumor. On gross examination, the tumor, which originated in the left ovary, was cystic multilocular and presented polyoid excrescences. Definitive histological exam showed a papillary proliferation lined by transitional cells without stroma infiltration. Mucinous cells lined some cavities. The diagnosis of proliferating Brenner tumor was made. Clinical and pathological characteristics of this rare entity will be discussed. PMID: 18325813 [PubMed - as supplied b...

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p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas

Histopathology — Tue, 18 Sep 2007 08:43:09 +0100

Histopathology Volume 51, Issue 4, Page 477-483, Oct 2007. Liao X Y, Xue W C, Shen D H, Ngan H Y S, Siu M K & Cheung A N(2007) Histopathology 51, 477–483p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomasAims: To investigate p63 expression in ovarian neoplasms.Metho... (Source: Histopathology)

[Brenner tumour of the vagina]

Annales de Pathologie — Sat, 01 Sep 2007 04:00:00 +0100

We report a sixth case and discuss the histogenesis of this tumour, as well as the differential diagnosis with the mixed tumour of the vagina. PMID: 18185458 [PubMed - indexed for MEDLINE] (Source: Annales de Pathologie)

Transitional Cell Carcinoma of the Endometrium Associated With Benign Ovarian Brenner Tumor: A Case Report With Immunohistochemistry Molecular Analysis and a Review of the Literature.

International Journal of Gynecological Pathology — Thu, 21 Jun 2007 12:21:56 +0100

Page: 298DOI: 10.1097/01.pgp.0000236943.28969.b2Authors: Giordano, Giovanna M.D.; D'Adda, Tiziana B.Sc.D.; Gnetti, Letizia M.D.; Merisio, Carla M.D.; Raboni, Stefano M.D. (Source: International Journal of Gynecological Pathology)

Three synchronized neoplasms of the female genital tract: an extraordinary presentation

Archives of Gynecology and Obstetrics — Thu, 24 May 2007 07:23:49 +0100

We report a case of unusual co-existence of multiple primary neoplasms of female genital tract. Case A 62-year-old gravida 2, para 2 was referred with spotting and vaginal discharge for about 6 months. Fractionate curettage was performed and documented endocervical squamous cell carcinoma in situ. Subsequently total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed. Final pathological report demonstrated cervical squamous cell carcinoma, right ovarian Brenner tumor, left ovarian granulosa tumor and endometrial polyps. Discussion Multiple primary neoplasms of female genital tract is a well-recognized yet rare occurrence. Although the presented case is probably an incidental event, the pathogenesis of the neoplastic proces...

HPV induced ovarian squamous cell carcinoma: case report and review of the literature

Archives of Gynecology and Obstetrics — Fri, 02 Mar 2007 08:40:17 +0100

Conclusion??The development of bone metastases in association with an ovarian squamous cell carcinoma is a rare finding, and it did not respond to treatment with a tyrosine kinase. A review of literature is presented. Content TypeJournal Article JournalArchives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

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Feasibility of screening for ovarian cancer using symptoms as selection criteria.

BJOG : An International Journal of Obstetrics and Gynaecology — Mon, 01 Jan 2007 07:00:00 +0100

CONCLUSIONS: This pilot study confirms the feasibility of screening for ovarian cancer using symptoms as selection criteria. Specificity was high and patient compliance good. Initial concerns about referral volumes and additional investigations and referrals generated were not confirmed. No ovarian cancers were detected in this pilot study, and this may be due to the size of the cohort. PMID: 17233861 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

[RSNA Education Exhibits] Developing an MR Imaging Strategy for Diagnosis of Ovarian Masses

Radiographics recent issues — Thu, 14 Sep 2006 04:00:00 +0100

Magnetic resonance (MR) imaging provides useful information for characterization of various ovarian masses as neoplastic or nonneoplastic and, when neoplastic, on a spectrum from benign to malignant. The use of MR imaging for diagnosis of ovarian masses includes consideration of morphologic characteristics and signal intensity characteristics on T1- and T2-weighted images. The morphologic characteristics of cystic masses, cystic and solid masses, and predominantly solid masses provide important information. In general, cystic masses represent benign tumors, whereas cystic and solid masses are strongly associated with malignancy. Predominantly solid masses include benign, borderline malignant, and malignant tumors. T1-weighted images provide useful information for characterization because h...

Expression and subcellular localization of maspin in human ovarian epithelial neoplasms: correlation with clinicopathologic features.

J Egypt Natl Canc In... — Wed, 14 Sep 2005 06:00:00 +0100

Conclusion: Maspin was expressed in a substantial proportion of ovarian tumors with poor prognostic parameters. These results may offer new insights regarding the role of maspin in ovarian cancer that may also impact diagnosis and treatment strategies. Moreover, variation in maspin expression between Brenner tumor and other epithelial surface ovarian tumors may indicate that the different histological types probably represent distinct disease entities and involve different molecular pathways. PMID: 16799655 [PubMed - in process] (Source: J Egypt Natl Canc In...)