MedWorm: Buerger's Disease

Molecular subtyping of male breast cancer by immunohistochemistry

Modern Pathology AOP — Fri, 04 Nov 2011 04:00:00 +0100

Authors: Robert Kornegoor, Anoek H J Verschuur-Maes, Horst Buerger, Marieke C H Hogenes, Peter C de Bruin, Joost J Oudejans, Petra van der Groep, Bernd Hinrichs & Paul J van Diest (Source: Modern Pathology AOP)

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Fast generation of 4D PET-MR data from real dynamic MR acquisitions.

Physics in Medicine and Biology — Sat, 08 Oct 2011 10:47:03 +0100

Authors: Tsoumpas C, Buerger C, King AP, Mollet P, Keereman V, Vandenberghe S, Schulz V, Schleyer P, Schaeffter T, Marsden PK Abstract We have implemented and evaluated a framework for simulating simultaneous dynamic PET-MR data using the anatomic and dynamic information from real MR acquisitions. PET radiotracer distribution is simulated by assigning typical FDG uptake values to segmented MR images with manually inserted additional virtual lesions. PET projection data and images are simulated using analytic forward projections (including attenuation and Poisson statistics) implemented within the image reconstruction package STIR. PET image reconstructions are also performed with STIR. The simulation is validated with numerical simulation based on Monte Carlo (GATE) which uses more...

New routing alternative for proximal anterior tibial artery bypass in patients with Buerger disease

Journal of Vascular Surgery — Mon, 26 Sep 2011 04:00:00 +0100

Femoral-anterior tibial artery bypasses with autogenous grafts are difficult to perform when sufficiently long saphenous veins are not available. We performed 12 bypasses on patients with Buerger disease during a 20-year period using a new intermuscular tunneling technique. The graft is passed from the thigh between the muscle compartments without penetrating the muscle fibers, providing an anatomically superior and shorter path. The primary patency rates were 75% at 5 years and 65% at 10 years. We believe that our tunneling technique is safe and durable and might be a viable alternative for proximal femoral-anterior tibial artery bypass in selected patients. (Source: Journal of Vascular Surgery)

[Knee disarticulation and through-knee amputation.]

Operative Orthopadie und Traumatologie — Fri, 23 Sep 2011 04:00:00 +0100

Authors: Baumgartner R Abstract OBJECTIVE: A knee disarticulation or a through-knee stump is superior compared to a transfemoral stump. The thigh muscles are all preserved, and the muscle balance remains undisturbed. The range of motion of the hip joint is not limited. The bulbous shape of the stump allows full weight bearing at the stump end and can easily be fitted with a prosthesis. An amputee with a bilateral knee disarticulation is able to walk "barefoot". INDICATIONS: A more distal amputation level, e.g., an ultra-short transtibial amputation, is not possible. Important alternative to transfemoral amputations. Possible for any etiology except for Buerger-Winiwarter's disease. New indications are infected and loosened total knee replacements. CONTRAINDICATIONS: Preservation of...

[Forefoot and midfoot amputations.]

Operative Orthopadie und Traumatologie — Sat, 17 Sep 2011 04:00:00 +0100

Authors: Baumgartner R Abstract OBJECTIVE: Partial foot amputations are feasible regardless of the causal condition, including peripheral vascular disease with a few exceptions. Compared to higher amputation levels, a good foot stump permits full end bearing and enables the patient, even with a hindfoot stump, to walk without the need for a prosthesis. The more peripheral the amputation level selected, the greater the need for gentle tissue handling and meticulous postoperative care, but also the greater the risk of a breakdown requiring stump revision surgery. In the forefoot, partial amputation of the metatarsals preserves the length of the stump and, thus, minimizes the loss of weight-bearing surface. The resection of metatarsal and midfoot bones without removing the toes, calle...

Flow-mediated vasodilation is augmented in a corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Buerger disease)

Journal of Vascular Surgery — Mon, 12 Sep 2011 04:00:00 +0100

Conclusions: Endothelial function of a corkscrew collateral artery in patients with Buerger disease is maintained, while endothelial function is impaired in a native artery in Buerger disease. (Source: Journal of Vascular Surgery)

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Thoracic respiratory motion estimation from MRI using a statistical model and a 2-D image navigator

Medical Image Analysis — Wed, 07 Sep 2011 04:00:00 +0100

Graphical abstract: Highlights: ► Respiratory motion model that can predict intra- and inter-cycle motion variability. ► PCA-based model applied using a real-time 2-D MRI ‘navigator’. ► Model application gives feedback on suitability of model to current breathing style. ► Motion model used to select optimal positioning for 2-D MRI ‘navigator’. ► Technique demonstrated for purpose of MRI-based motion correction of PET imaging.Abstract: Respiratory motion models have potential application for estimating and correcting the effects of motion in a wide range of applications, for example in PET-MR imaging. Given that motion cycles caused by breathing are only approximately repeatable, an important quality of such models is their ability to capture and estimate the intra- and in...

Pluristem's PLX Cells Receive Orphan Drug Status for Treatment of Buerger's Disease

Medical News (via PRIMEZONE) — Thu, 25 Aug 2011 10:59:00 +0100

HAIFA, Israel, Aug. 25, 2011 (GLOBE NEWSWIRE) -- Pluristem Therapeutics, Inc. (Nasdaq:PSTI) (TASE:PLTR) today announced that on August 22, 2011, the U.S. Food and Drug Administration (FDA) designated Pluristem's PLX cells orphan status for the treatment of thromboangiitis obliterans (Buerger's disease). The Company also announced that a concurrent application in Europe at the EMA's Committee for Orphan Medicinal Products is pending. (Source: Medical News (via PRIMEZONE))

Management of thromboangiitis obliterans using distraction osteogenesis: A retrospective study

Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1) — Wed, 17 Aug 2011 23:00:00 +0100

Conclusion: The principle of the distraction osteogenesis including neoangiogenesis can be used for treatment of TAO and has an acceptable complication rate. (Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1))

Effectiveness of bosentan in the treatment of ischemic lesions in a case of thromboangiitis obliterans (Buerger disease): A case report.

Dermatol Online J — Wed, 10 Aug 2011 18:30:03 +0100

We report the case of a 35-year-old woman with active TAO, refractory to smoking cessation and conventional therapy, who exhibited a favorable clinical response to treatment with bosentan, an oral dual endothelin receptor antagonist, administered on a compassionate-use basis. Six months after starting bosentan therapy, the pain and trophic lesions in the patient's toes had completely disappeared. Bosentan was well tolerated, without any observed adverse reaction. The findings of this case report suggest that bosentan may be considered a therapeutic option for patients with active disease, despite quitting smoking, or for those who fail in absolute abstention from smoking. PMID: 21810389 [PubMed - as supplied by publisher] (Source: Dermatol Online J)

Longitudinal changes of fractional anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study

European Archives of Psychiatry and Clinical Neuroscience — Fri, 05 Aug 2011 05:59:37 +0100

Abstract Diffusion tensor imaging (DTI) demonstrates decline of fractional anisotropy (FA) as a marker of fiber tract integrity in Alzheimer’s disease (AD). We aimed to assess the longitudinal course of white matter microstructural changes in AD and healthy elderly control (HC) subjects and to evaluate the effects of treatment with the cholinesterase inhibitor galantamine on white matter microstructure in AD patients. We enrolled 28 AD patients and 11 healthy elderly control subjects (HC). AD patients were randomly assigned to 6-month double-blind galantamine treatment or placebo, with a 6-month open-label extension phase. DTI was performed at baseline, as well as at 6 and 12-month follow-up in AD patients. The HC subjects underwent DTI at baseline and 12-month follow-up...

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Does a species of Rickettsia play a role in the pathophysiology of Buerger's disease?

Vascular — Thu, 28 Jul 2011 23:00:00 +0100

We report a patient with Buerger's disease for whom a left below-knee amputation was done. Twenty-five biopsies for DNA extraction were obtained from the arteries, veins and microvasculature of the amputated limb. Three samples were positive for Rickettsia. The finding may explain the proliferation of endothelial cells in the pathology of Buerger's disease, segmental nature of the disease, involving small- and medium-sized vessels, and the prevalence of Buerger's disease among the low socioeconomic class of the society. Understanding the infectious etiology of Buerger's disease would be invaluable, since early antibiotic therapy or even vaccination might have prevented the limb loss in the current and other cases of Buerger's disease. The authors suggest that paraffin blocks of Buerger's d...

In vitro effects of perifosine, bortezomib and lenalidomide against hematopoietic progenitor cells from healthy donors

Investigational New Drugs — Wed, 13 Jul 2011 06:17:29 +0100

Summary The novel AKT inhibitor perifosine possesses myelopoiesis-stimulating effects in rodents. We studied the in vitro effects of the novel agents perifosine, bortezomib and lenalidomide in addition to adriamycin against normal human hematopoietic progenitor cells (HPC) using different clonogenic and non-clonogenic assays. All agents inhibited colony-forming unit (CFU) formation, perifosine inhibiting mainly CFU-granulocyte/macrophage formation and the other agents burst-forming unit-erythroid formation. Perifosine combined with lenalidomide or adriamycin tended to act antagonistically in suppressing CFU formation. Despite their inhibition of CFU formation, perifosine, bortezomib and lenalidomide induced only slight or moderate cytotoxicity in CD34+ selected HPC, as asse...

Reconstruction of the Soft Tissue Defects of Foot and Ankle with Neural-Island Flaps: Mono-Institutional Case Series

Journal of Reconstructive Microsurgery — Tue, 28 Jun 2011 23:00:00 +0100

J reconstr MicrosurgDOI: 10.1055/s-0031-1281514ABSTRACTThe aim of this report is to show the results obtained from using the neural-island flap to cover the soft tissue defects of the foot and ankle. This is the first report of the neural-island flap series since the introduction of this flap to the literature in 2003. Between 2002 and 2009 “neural-island flap” was used to treat 20 patients of various lesions on the foot and ankle. All of the patients had serious soft tissue defects that compromised tendons, bones, or joints. In 16 patients, the tissue defects were completely and successfully covered with an uncomplicated postoperative course. In 4 patients the flaps presented venous congestion and intermittent bleeding and leech application was performed for 2 to 3 days postop...

Color Doppler Flows of Corkscrew Collaterals in Thromboangiitis Obliterans (Buerger's Disease) Using Color Duplex Ultrasonography

Journal of the American College of Cardiology — Sat, 18 Jun 2011 15:24:35 +0100

We classified corkscrew collaterals into 4 types by artery amplitude and color Doppler flow formation pattern as follows: type I, large snake sign with an artery amplitude >5 mm being similar to or greater than amplitudes of original conduit arteries (A, Online Video 1); type II, small snake sign with an artery amplitude >3 and ≤5 mm, most of the corkscrew collaterals with an amplitude of ≤3 mm being shown as dot signs (B, Online Video 2); type III, dot sign with corkscrew collaterals with an amplitude >1 and ≤3 mm shown as a striped pattern of the side row (C, Online Video 3); and type IV, small dot sign with most of the corkscrew collaterals with an amplitude of ≤1 mm shown as random points but not a striped pattern of the side row (D, Online Video 4). (Source: Journal of the Ame...

Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease.

Neurobiology of Aging — Wed, 15 Jun 2011 23:00:00 +0100

In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. PMID: 21684041 [PubMed - as supplied by publisher] (Source: Neurobiology of Aging)

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Wedding gifts when the bridal registry is picked over

Wash Post Health — Wed, 08 Jun 2011 14:21:30 +0100

Bridal registries, like so many things, favor the proactive. Popular items get snagged by the early birds, leaving the rest of us with a short list of catchpenny choices that just don’t seem quite right. What’s a procrastinator to do? “Be thoughtful and splurge a little,” said Sarah Newell, lifestyle editor for TheKnot.com, “It’s a good time to go for those larger-ticket items they wouldn’t have bought themselves.” Newell suggested that those late to the gift game glean the couple’s interests from their registry and then shop accordingly: “If you see that they picked out a lot of wine-related items, such as glasses or wine racks, consider getting them a decanter or tickets to a wine tasting.” Read full article >> (Source: Wash Post Health)

Cell‐based therapy for patients with vascular dementia

Psychogeriatrics — Tue, 31 May 2011 23:00:00 +0100

AbstractThe homeostasis of neuronal cells is maintained by the cerebral circulation and blood–brain barrier. Circulating bone marrow‐derived immature cells, including CD34‐positive (CD34+) cells, have been implicated in homeostasis of the cerebral microvasculature. Decreased levels of circulating CD34+ cells, associated with ageing and/or cardiovascular risk factors, correlate with poor clinical outcomes in patients with cerebrovascular and cardiovascular diseases. Clinical trials with local transplantation of bone marrow‐derived immature cells for patients with limb ischaemia, including Buerger's disease and arteriosclerosis obliterans, have been shown to improve impaired microcirculation. In the present review, current findings about the correlation between circulating immature c...

Vascular Function and Circulating Progenitor Cells in Thromboangiitis Obliterans (Buerger's Disease) and Atherosclerosis Obliterans

Journal of Vascular Surgery — Wed, 25 May 2011 20:10:10 +0100

Conclusion: The number and function of circulating progenitor cells (CPCs) are decreased in patients with atherosclerosis but not in patients with Buerger's disease. Summary: A healthy endothelium, mediated mainly by nitric oxide, maintains vascular structure and tone by regulating the balance between vasoconstriction and vasodilation as well as growth promotion and growth inhibition and antioxidation and pro-oxidation (Vanhoutte P, Hypertension 1989;13:658-67). Buerger's disease and atherosclerosis are both associated with endothelial dysfunction (Makita S, Circulation 1996;94:11211-5). However, although the mortality rate of patients with atherosclerosis is higher than in age-matched controls, the mortality rate of patients with Buerger's disease is not (Criqui MH, N Engl J Med 1992;326...

Circulating platelet microparticles: a potential predictive marker for the severity of peripheral arterial diseases

Cardiovascular Revascularization Medicine — Sat, 30 Apr 2011 23:00:00 +0100

The aim was to determine the relationship between platelet activation (represented in PMPs CD 63 and CD 62) and the severity of PAD. This is a prospective study conducted along the period of June 2008 to June 2009 on patients with lower extremity peripheral vascular disease due to atherosclerosis or other cause of arteriopathy (e.g., Buerger's disease) together with 15 age-/sex-matched healthy controls. Patients were divided into two groups: Group (Gr.) A: patients with moderate disease (intermittent claudication IC) and Group (Gr.) B: patients with severe disease [rest pain and/or tissue loss, i.e., critical limb ischemia (CLI)]. Platelet-poor plasma from the venous samples was subjected to flow cytometry to detect PMPs. Exclusion criteria included refusal of consent, renal failure, pres...

A review on thromboangiitis obliterans pathophysiology: thrombosis and angiitis, which is to blame?

Vascular — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Fazeli B, Rezaee SA A century has passed since thromboangiitis obliterans (TAO), or Buerger's disease, was first described, but the etiology remains unclear. It is still uncertain as to whether thrombosis or vascular inflammation is the first event. TAO is an episodic inflammatory and thrombotic-occlusive vascular disease of unknown origin. The involvement of the distal vessels and nerves within the neuro-vascular bundles occurs almost always in legs and occasionally in arms. The cumulative data demonstrate that at the cellular and molecular levels, at least four main components of inflammatory reactions, including endothelial cells, platelets, leukocytes and sensory neurons, might be involved in TAO pathogenesis. The interactions among these cells in an altered microenvironme...

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[Articles] Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

Lancet Neurology — Wed, 20 Apr 2011 03:43:20 +0100

We provide verification of the efficacy, safety, and biological relevance of florbetaben (18F) amyloid-β PET and suggest its potential as a visual adjunct in the diagnostic algorithm of dementia. (Source: Lancet Neurology)

Antihypertensive Therapy Is Associated with Reduced Rate of Conversion to Alzheimer's Disease in Midregional Proatrial Natriuretic Peptide Stratified Subjects with Mild Cognitive Impairment

Biological Psychiatry — Sun, 03 Apr 2011 23:00:00 +0100

Conclusions: These data seem to support the notion of a potential impact of circulatory function for the prognosis of AD at a prodromal stage. The MR-proANP levels may be useful to predict the effect of antihypertensive treatment on conversion rates to AD in subjects with MCI. (Source: Biological Psychiatry)

Hierarchical adaptive local affine registration for fast and robust respiratory motion estimation

Medical Image Analysis — Thu, 03 Mar 2011 00:00:00 +0100

Graphical abstract: Research highlights: ► Non-rigid image registrations are computationally complex. ► Ongoing research in alternative approaches like multiple locally affine components. ► We consider a hierarchical affine block registration scheme with regular splitting. ► A novel adaptive splitting reduces registration error by 49.1%.Abstract: Non-rigid image registration techniques are commonly used to estimate complex tissue deformations in medical imaging. A range of non-rigid registration algorithms have been proposed, but they typically have high computational complexity. To reduce this complexity, combinations of multiple less complex deformations have been proposed such as hierarchical techniques which successively split the non-rigid registration problem into multiple lo...

Abnormal plasma fibrin clot characteristics are associated with worse clinical outcome in patients with peripheral arterial disease and thromboangiitis obliterans

Atherosclerosis — Wed, 16 Feb 2011 00:00:00 +0100

Abstract: Background: A role of blood coagulation in the pathogenesis of peripheral arterial disease (PAD) and Buerger's disease, or thromboangiitis obliterans (TAO), remains unclear.Objective: To test the hypothesis that PAD and TAO are associated with prothrombotic phenotype of a fibrin clot.Patients and methods: Ex vivo plasma fibrin clot permeability, turbidimetry and efficiency of fibrinolysis were investigated in 106 patients with PAD and 20 patients with TAO and compared with the respective control groups matched for age, sex, and cardiovascular risk factors. The progression of PAD and TAO were evaluated during follow-up of 3–7.5 years. PAD patients were characterized by lower clot permeability (−18.8%, p=0.005), shorter lag phase (−35.3%, p (Source: Atherosclerosis)

Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation

Annals of Hematology — Fri, 11 Feb 2011 11:50:05 +0100

Abstract Extramedullary relapses after allogeneic stem cell transplantation, especially within the central nervous system (CNS), are not only difficult to treat but also associated with poor outcome. Although the graft-versus-leukemia (GvL) effect is nowadays accepted and well documented, it remains controversial whether one can make use of GvL effects in immunological-restricted areas (“sanctuary sites”) like the central nervous system. Here, we present data of three hematological patients suffering from isolated CNS relapse of CML or AML after allogeneic stem cell transplantation. Patients received in addition to chemotherapy intrathecal infusions of donor lymphocytes by CD14 depletion of peripheral blood mononuclear cells from the correspondent allogeneic donor. Ref...

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Buerger Disease (Thromboangiitis Obliterans): A Clinical Diagnosis

Advances in Skin and Wound Care — Wed, 22 Dec 2010 15:55:17 +0100

Thromboangiitis obliterans, or Buerger disease, is a debilitating vascular disease with a well-known pronounced link to cigarette smoking and, more specifically, to the nicotine component of tobacco inhalation. Buerger disease is an inflammatory occlusive disorder that primarily affects the medium and small vessels of the extremities. In the present case report, a 46-year-old man, nonforthcoming smoker, presented to the authors' clinic with a deep ulcer at the head of the second metatarsal. Evidently, although the patient continued to smoke, the ulcer responded to therapy but regressed. Once the history was elaborated, the patient stopped smoking, and the ulcer healed completely within 2 months. Follow-up appointments proved to be unremarkable and to the authors' knowledge, there has not b...

Tramadol-Induced Flushing Managed with Aspirin Premedication

Journal of Pain and Symptom Management — Wed, 01 Dec 2010 00:00:00 +0100

We report a case of tramadol-induced flushing that was successfully managed by premedicating with aspirin. (Source: Journal of Pain and Symptom Management)

Coventry Applauds Victory For Life Insurance Consumers

Health News from Medical News Today — Sat, 20 Nov 2010 10:00:00 +0100

Coventry, the creator of the secondary market for life insurance in the U.S., applauds the New York Court of Appeals decision in Kramer v. Phoenix Life Insurance Company as a significant victory for life insurance consumers and the secondary market for life insurance. "There are two prongs to this decision, one of which will resonate broadly," said Alan Buerger, CEO of Coventry... (Source: Health News from Medical News Today)

Simultaneous PET–MR acquisition and MR-derived motion fields for correction of non-rigid motion in PET

Annals of Nuclear Medicine — Wed, 15 Sep 2010 05:51:03 +0100

Conclusions Combined PET–MR acquisitions potentially allow PET motion compensation in whole-body acquisitions without prolonging PET acquisition time or increasing radiation dose. This, to the best of our knowledge, is the first study to demonstrate that simultaneously acquired MR data can be used to estimate and correct for the effects of non-rigid motion in PET. Content Type Journal ArticleDOI 10.1007/s12149-010-0418-2Authors Charalampos Tsoumpas, Division of Imaging Sciences, King’s College London, 4th Floor Lambeth Wing, St. Thomas’ Hospital, Westminster Bridge Rd, London, SE1 7EH UKJane E. Mackewn, Division of Imaging Sciences, King’s College London, 4th Floor Lambeth Wing, St. Thomas’ Hospital, Westminster Bridge Rd, London, SE1 7EH UKPhilip Halsted,...

Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial disease.

Journal of the American Medical Informatics Association — Tue, 31 Aug 2010 23:00:00 +0100

Conclusion This study demonstrates use of the EMR to ascertain phenocopies, phenotype heterogeneity and relevant covariates to enable a GWAS of PAD. Biorepositories linked to EMR may provide a relatively efficient means of conducting GWAS. PMID: 20819866 [PubMed - in process] (Source: Journal of the American Medical Informatics Association)

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[Therapy of peripheral vessel stenosis and occlusion in patients with thromboangiitis obliterans.]

Der Radiologe — Wed, 18 Aug 2010 23:00:00 +0100

Authors: Sandner TA, Degenhart C, Becker-Lienau J, Reiser MF, Treitl M Vasculitis consists of a group of diseases characterized by an inflammatory process of the vessel wall. There is a wide variation in symptoms and almost any organ or tissue can be affected. Thromboangiitis obliterans (TAO; also known as Buerger's disease) is a special form of vasculitis with recurring inflammation and thrombosis of small and medium size arteries and veins of the hands and feet. To date the etiology still remains unclear but there is a strong association with the use of tobacco products. Ulcerations and gangrene of the extremities are common complications often resulting in the need for amputation of the extremity involved. Treatment of TAO includes both surgical and non-surgical methods but there is...

Immunohistochemical properties in the patients with Buerger's disease—possible role of plasminogen activator inhibitor-1 for preservation of vessel wall architecture

Cardiovascular Pathology — Thu, 12 Aug 2010 23:00:00 +0100

Conclusion: In Buerger's disease, PAI-1 was strongly expressed around the internal elastic lamina, while both uPA and MMP-3 were slightly recognized on vessel walls. These findings could be one of the reasons the general architecture of vessel walls in Buerger's disease is preserved. (Source: Cardiovascular Pathology)

Clinical research Buerger’s disease as an indicator of socioeconomic development in different societies, a cross-sectional descriptive study in the North-East of Iran

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:06 +0100

Conclusions: There is a lack of correspondence between BD and decline in the prevalence of smoking in developed countries. Also, duration and smoking habit varied in the studied patients. On the other hand, the strong dependence of BD on low socioeconomic conditions, as revealed in this research, implies that socioeconomic status may be a risk factor for initiation of BD. Moreover, the prevalence of BD might be an indicator of socioeconomic development in different societies. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

t2cure's Cellular Therapeutic Receives Orphan Drug Designation from FDA, EMA Recommendation for Buerger's Disease

HSMN NewsFeed — Thu, 24 Jun 2010 14:40:41 +0100

FRANKFURT, June 24, 2010 (HSMN NewsFeed) -- t2cure GmbH, a biopharmaceutical company developing and marketing stem cell-based regenerative therapies, announced today that the FDA has granted orphan drug designation to t2c001 for the treatment of Buerger'... Biopharmaceuticals, Regenerative Medicine, FDA, Regulatoryt2cure, t2c00, Buerger's Disease, thromboangiitis obliterans (Source: HSMN NewsFeed)

Efficacy of Bosentan in Digital Ischemic Ulcers

Annals of Vascular Surgery — Tue, 15 Jun 2010 14:30:58 +0100

We report two cases of digital necrosis showing a very satisfactory response to treatment with bosentan, a dual endothelin receptor antagonist. (Source: Annals of Vascular Surgery)

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Classification of Corkscrew Collaterals in Thromboangiitis Obliterans (Buerger's Disease).

Circulation Journal — Tue, 08 Jun 2010 23:00:00 +0100

Conclusions: The prevalence of ischemic ulcers is significantly higher in patients who have small corkscrew patterns in distal segments of limb collaterals than in patients who have large corkscrew collaterals. PMID: 20534945 [PubMed - as supplied by publisher] (Source: Circulation Journal)

Long-term immunity and immune response to a booster dose following vaccination with the inactivated Japanese encephalitis vaccine IXIARO((R)), IC51.

Vaccine — Tue, 08 Jun 2010 23:00:00 +0100

Authors: Dubischar-Kastner K, Eder S, Buerger V, Gartner-Woelfl G, Kaltenboeck A, Schuller E, Tauber E, Klade C IC51 (IXIARO((R)), JESPECT((R))) is a recently approved prophylactic Japanese encephalitis virus vaccine with a two-vaccine primary immunization regimen. In this phase 3 trial, after primary immunization with a Day 0/28 dose schedule, seroprotection rates were 83%, 58% and 48% at Month 6, Month 12 and Month 24, respectively. A booster dose at Month 11 and/or Month 23 in subjects with neutralizing antibody titers below the limit of detection (defined as a serum dilution giving a 50% reduction of plaque counts in a plaque reduction neutralization test [PRNT50]<1:10) led to 100% seroconversion. After a single-dose immunization (incomplete primary immunization), only 9% of sub...

Immature erythroid cells: A new source for therapeutic angiogenesis?

Journal of Molecular and Cellular Cardiology — Sun, 30 May 2010 23:00:00 +0100

Therapeutic angiogenesis has emerged as a novel strategy for the treatment of critical limb ischemia (CLI), including that associated with arteriosclerosis obliterans (ASO) and Buerger disease (also known as thromboangiitis obliterans [TAO]) . Endothelial progenitor cells (EPCs), first identified by Asahara et al. in 1997 in adult peripheral blood mononuclear cells, were shown to be recruited and incorporated into the site of angiogenesis in cases of tissue ischemia. This suggests that hematopoietic cells have a therapeutic potential for ischemic cardiovascular diseases. These observations have generated great interest for studying therapeutic angiogenesis by using hematopoietic-derived cells, and many clinical studies on cell-based therapy by using bone marrow cells for treatment of ische...

Successful Repair for a Ruptured Venous Aneurysm: An Unusual Complication of Venous Arterialization in Buerger's Disease

Annals of Vascular Surgery — Thu, 13 May 2010 23:00:00 +0100

We report a ruptured venous aneurysm, an unusual complication of venous arterialization for lower limb ischemia in Buerger's disease. Arteriovenous shunt ligation and aneurysm resection were performed successfully, with the distal limb perfusion preserved. By our very limited experience, venous arterialization may be ineffective on improving lower limb ischemia with Buerger's disease. (Source: Annals of Vascular Surgery)

Presence of Cryofibrinogen in a Cannabis user with Digital Ischaemia

EJVES Extra — Thu, 15 Apr 2010 23:00:00 +0100

In conclusion, cannabis arteritis should be considered in case of digital arteritis and search for cannabis use should be preformed in this case. Search for cryofibrinogenaemia could be useful in patients with digital ischaemia. (Source: EJVES Extra)

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Fifteen years of infrapopliteal arterial reconstructions with cryopreserved venous allografts for limb salvage

Journal of Vascular Surgery — Mon, 29 Mar 2010 14:53:11 +0100

Conclusion: Cryopreserved saphenous vein allografts are a valuable alternative to prosthetic materials when autologous veins are not available. Our limb salvage and patency rates are higher then those described for prosthetic grafts at the infrapopliteal level in most studies. Moreover, these grafts are resistant to infection when performed for revascularization in patients with an infected ulcer. Better graft and patient selection, better graft surveillance and immunologic matching, and standard use of statins could possibly improve the results even further. Shortage in availability might be a limiting factor for their widespread use. (Source: Journal of Vascular Surgery)

Midregional Proenkephalin A and N-terminal Protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation

Journal of Neuroimmunology — Mon, 08 Mar 2010 00:00:00 +0100

Abstract: Midregional Proenkephalin A (MR-PENK A) and N-terminal Protachykinin A (NT-PTA) are stable fragments of the precursor peptides for enkephalins and substance P, respectively. We measured MR-PENK A and NT-PTA concentrations by sensitive chemiluminescence immunoassays in cerebrospinal fluid (CSF) of 19 neurologically healthy controls (NHC), 28 patients with other neurologic disorders (OND), 70 patients with dementia disorders (38 Alzheimer's disease [AD], 8 dementia with Lewy bodies [DLB], 12 frontotemporal dementia [FTD], and 12 patients with vascular dementia [VD]), and 16 patients with acute neuroinflammation (AN). Median concentrations of NT-PTA were decreased in all patient groups compared to NHC showing significant differences between patients with NHC and AN (p (Source: Journ...

Continuous dopaminergic stimulation by pramipexole is effective to treat early morning akinesia in animal models of Parkinson's disease: A pharmacokinetic-pharmacodynamic study using in vivo microdialysis in rats

Synapse — Mon, 01 Mar 2010 00:00:00 +0100

Short-acting dopamine (DA) agonists are usually administered several times a day resulting in fluctuating plasma and brain levels. DA agonists providing continuous dopaminergic stimulation may achieve higher therapeutic benefit for example by alleviating nocturnal disturbances as well as early morning akinesia. In the present study continuous release (CR) of pramipexole (PPX) was maintained by subcutaneous implantation of Alzet® minipumps, whereas subcutaneous PPX injections were used to mimic PPX immediate release (IR) in male Wistar rats. In the catalepsy bar test, PPX-CR (1 mg/kg/day) reversed the haloperidol-induced motor impairment in the morning and over the whole observation period of 12h. In contrast, PPX-IR (tid 1 mg/kg, pre-treatment the day before) was not effective in the morn...

CT Angiography of the Lower Extremities

Radiologic Clinics of North America — Mon, 01 Mar 2010 00:00:00 +0100

CT angiography (CTA) of the lower extremities has evolved into a robust noninvasive angiographic technique with the advent of 16 and 64 multidetector computed tomographic systems and advances in system design. CTA has displaced conventional catheter arteriography in a large range of applications and is predominantly used in the evaluation of atherosclerotic peripheral arterial occlusive disease in symptomatic patients who are candidates for intervention. Other disease entities including atheroembolism andthromboembolism, aneurysmal disease, and arteritides including Buerger disease and Takayasu arteritis can be precisely evaluated by CTA. Particular applications include arterial vascular mapping for free flap transfers and fibular grafts and evaluation of trauma, before and following ortho...

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CT Angiography of the Lower Extremities.

Radiologic Clinics of North America — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Foley WD, Stonely T CT angiography (CTA) of the lower extremities has evolved into a robust noninvasive angiographic technique with the advent of 16 and 64 multidetector computed tomographic systems and advances in system design. CTA has displaced conventional catheter arteriography in a large range of applications and is predominantly used in the evaluation of atherosclerotic peripheral arterial occlusive disease in symptomatic patients who are candidates for intervention. Other disease entities including atheroembolism andthromboembolism, aneurysmal disease, and arteritides including Buerger disease and Takayasu arteritis can be precisely evaluated by CTA. Particular applications include arterial vascular mapping for free flap transfers and fibular grafts and evaluation of t...

Differential effects of semantic processing on memory encoding

Human Brain Mapping — Tue, 16 Feb 2010 00:00:00 +0100

Deeper semantic processing of words leads to enhanced memory encoding (depth of processing effect). The left inferior prefrontal cortex (LIPC) and the left hippocampus are known to be involved in this effect. We tested the hypothesis that different semantic encoding processes contribute qualitatively differently to memory encoding. In a memory experiment using functional magnetic resonance imaging, we compared three different encoding tasks: a nonsemantic alphabetical, an animacy decision, and a size comparison tasks. Recognition memory was tested subsequently. We hypothesized that the size comparison task would activate brain areas involved in the processing of object features and that this would be associated with successful memory encoding. Results showed that the size comparison task l...

Diagnostic problems and delay of diagnosis in amyotrophic lateral sclerosis

Clinical Neurology and Neurosurgery — Thu, 21 Jan 2010 16:36:24 +0100

Conclusion: Our study confirms that diagnosis of ALS is still a common clinical problem and shows the need of sensitive and specific diagnostic tests. (Source: Clinical Neurology and Neurosurgery)

Effect of eNOS and ET-1 Polymorphisms in Thromboangiitis Obliterans

Clinical and Applied Thrombosis/Hemostasis — Thu, 21 Jan 2010 07:38:59 +0100

Thromboangiitis obliterans (TAO), or Buerger disease, is a segmental occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. It is strongly connected to the use of tobacco products, especially smoking. Smoking cessation is obligatory for success of the medical treatment. In the current study, we investigated the prevalence of endothelial nitric oxide synthase (eNOS) 894 G->T and endothelin-1 (ET-1) 8000 T->C polymorphisms in association with TAO to reveal any possible involvement in the TAO pathophysiology. The T allele of the eNOS 894 G->T polymorphism was found to be associated with the prevention of TAO. (Source: Clinical and Applied Thrombosis/Hemostasis)

Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine.

Vaccine — Thu, 07 Jan 2010 00:00:00 +0100

CONCLUSION: Compared to a previous study intensified dosing and/or i.d. injections enhanced the response rates to the vaccine IC41 in three assays measuring T cell function. Immunization with IC41 was generally safe in this study. These results justify testing IC41 in further clinical trials with HCV-infected individuals. PMID: 20060945 [PubMed - as supplied by publisher] (Source: Vaccine)

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[Etiological profile of digital necrosis of the upper limbs: Analysis of 25 cases.]

Journal des Maladies Vasculaires — Tue, 01 Dec 2009 00:00:00 +0100

CONCLUSION: Digital necrosis is a common symptom, revealing a vascular pathology. Its causes are diverse. In women, it first suggests a connective tissue disease whereas in men, a diffuse arteriopathy. The etiological diagnosis strategy should consider drug intake, anamnesis and Raynaud's phenomenon history. However, in all cases the etiology investigations should not delay the treatment in order to preserve functional prognosis. PMID: 19959303 [PubMed - as supplied by publisher] (Source: Journal des Maladies Vasculaires)

Stem Cell Therapy: A Promising and Prospective Approach in the Treatment of Patients With Severe Buerger's Disease

Clinical and Applied Thrombosis/Hemostasis — Thu, 12 Nov 2009 05:30:03 +0100

No effective blood-flow enhancement therapies are available for patients with severe peripheral arterial disease (SPAD), thus amputation remains the only option for relief of rest pain or gangrene. Autologous bone marrow—derived stem cell therapy (ABMSCT) is an emerging modality to induce angiogenesis from endothelial progenitors. A total of 5 patients with SPAD were treated by ABMSCT using isolated CD34+ cells with characterized phenotype administered by intramuscular injections. The follow-up before and 1, 3, 6, 9, and 12 months after ABMSCT was based on clinical (rest pain, walking distance without pain, nonhealing ulcers, ankle-brachial index [ABI]) and laboratory (angiography, duplex and laser ultrasonography, TcPO2) parameters. Significant improvement of pain and walking distan...

Occlusion of the celiac trunk, the inferior mesenteric artery and stenosis of the superior mesenteric artery in peripheral thrombangiitis obliterans.

VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases — Sun, 01 Nov 2009 00:00:00 +0100

In this study, a case of Buerger's disease with mesenteric involvement diagnosed before the onset of acute mesenteric ischaemia and managed endovascularly is reported. PMID: 19998262 [PubMed - in process] (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)

The surgical pathology of large vessel disease

Diagnostic Histopathology — Mon, 26 Oct 2009 00:00:00 +0100

Abstract: The common disorders that affect large vessels are atherosclerosis, idiopathic proximal aortic dilatation (annulo-aortic ectasia), and cranial arteritis. Although an increasing number of patients undergo vascular surgery, especially carotid endarterectomy, we receive only about 250 vascular biopsies annually. Most are diagnosed easily. The most difficult diagnostic areas are the assessment of inflammatory infiltrates in aortic biopsies, the accurate identification of healed or healing cranial arteritis and the differentiation of Buerger's disease from atherosclerosis. (Source: Diagnostic Histopathology)

Biological Marker Candidates of Alzheimer's Disease in Blood, Plasma, and Serum.

CNS Neuroscience and Therapeutics — Tue, 13 Oct 2009 23:00:00 +0100

Authors: Schneider P, Hampel H, Buerger K At the earliest clinical stages of Alzheimer's disease (AD), when first symptoms are mild, making a reliable and accurate diagnosis is difficult. AD related brain pathology and underlying molecular mechanisms precede symptoms. Biological markers can serve as supportive early screening and diagnostic tools as well as indicators of presymptomatic biochemical change. Moreover, biomarkers cover a variety of roles and functions such as disease prediction, indicating disease acuity and progression, and may ensure biological mapping of treatment outcome. Early screening, detection, and diagnosis of AD would permit earlier disease modifying intervention at potentially reversible stages. To date, most established biological markers from both cerebrospin...

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Platelet microparticle levels: a biomarker of thromboangiitis obliterans (Buerger's disease) exacerbation

Journal of Cellular and Molecular Medicine — Sat, 10 Oct 2009 00:00:00 +0100

(Source: Journal of Cellular and Molecular Medicine)

Platelet microparticle levels: A biomarker of thromboangiitis obliterans (Buerger's disease) exacerbation.

J Cell Mol Med — Fri, 09 Oct 2009 23:00:00 +0100

Authors: Darnige L, Helley D, Fischer AM, Emmerich J, Smadja DM, Fiessinger JN PMID: 19818096 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)

Combined Distal Venous Arterialization and Free Flap for Patients with Extensive Tissue Loss

Annals of Vascular Surgery — Thu, 17 Sep 2009 00:00:00 +0100

Conclusion: DVA can be effective as a procedure for limb salvage in patients without graftable distal arteries, and a combined free flap is effective and functions as a bridgehead for blood supply to the ischemic zone. (Source: Annals of Vascular Surgery)

Association between periodontitis and anti-cardiolipin antibodies in Buerger disease.

Journal of Clinical Periodontology — Tue, 11 Aug 2009 23:00:00 +0100

Conclusion: Elevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein. PMID: 19678860 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)

Efficacy of the transfer function index using the pulse volume recording as a parameter to assess intermittent claudication

Surgery Today — Tue, 28 Jul 2009 18:47:06 +0100

Conclusion TFIcalf was useful to distinguish moderate or severe IC from mild IC in diabetic patients even if the ABPI was sufficient in nondiabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-3940-xAuthors Rieko Nakashima, Tokyo Medical and Dental University Graduate School Department of Vascular and Applied Surgery 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8519 JapanYoshinori Inoue, Tokyo Medical and Dental University Graduate School Department of Vascular and Applied Surgery 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8519 JapanNorihide Sugano, Tokyo Medical and Dental University Graduate School Department of Vascular and Applied Surgery 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8519 JapanMasatoshi Jibiki, Tokyo Medical and Dental University Gra...

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Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model.

Experimental Neurology — Thu, 16 Jul 2009 23:00:00 +0100

Authors: Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J Cell proliferation of neural progenitors in the subventricular zone (SVZ) of Parkinson disease (PD) patients and animal models is decreased. It was previously demonstrated that the neurotransmitter dopamine modulates cell proliferation in the embryonic brain. The aim of the presentstudy was to analyze whether oral treatment with the dopamine receptor agonist pramipexole (PPX) modulates adult neurogenesis in the SVZ/ olfactory bulb system in a dopaminergic lesion model. 6-Hydroxydopamine (6-OHDA) lesioned adult rats received either PPX (1,0 mg/kg) or PBS orally twice daily and bromodeoxyuridine (BrdU, a cell proliferation marker) for 10 days and were perfused...

Validation of Alzheimer's disease CSF and Plasma Biological Markers The Multi-Center Reliability Study of the Pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI).

Experimental Gerontology — Mon, 15 Jun 2009 23:00:00 +0100

CONCLUSION: The use of frozen rather than fresh samples renders higher diagnostic accuracy within a multicenter context. We confirmed the feasibility of a multi-centre AD biomarker programme for future clinical trials. PMID: 19539742 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)

TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast Cancer

Cancer Research — Mon, 15 Jun 2009 04:00:00 +0100

Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer. In a cellular model of this phenotype using differential gene expression analysis, we identified TOB1 to be up-regulated depending on EGF stimulation and transduction through phosphorylation of HER2 tyrosine 1248. mRNA expression analysis of breast cancers from a cohort of node-negative patients showed significantly shortened distant metastasis-free survival for patients with high TOB1 expression. In subsequent tissue microarray studies of 725 clinical samples, high HER2 and EGF protein levels were significantly correlated with TOB1 expression in breast cancer, whereas EGFR and EGF levels c...

Intraoperative Fluoroscopy-Guided Removal of Orbital Foreign Bodies.

Ophthalmic Plastic and Reconstructive Surgery — Thu, 21 May 2009 04:42:46 +0100

The authors report their experience using real-time intraoperative orbital fluoroscopy as an aid in the surgical removal of orbital foreign bodies.Page: 215DOI: 10.1097/IOP.0b013e3181a3006aAuthors: Cho, Raymond I. M.D. *+; Kahana, Alon M.D., Ph.D. *; Patel, Bhupendra M.D. ++; Sivak-Callcott, Jennifer M.D. [S]; Buerger, Daniel E. M.D., F.A.C.S. |; Durairaj, Vikram D. M.D. [P]; Vidor, Ira M.D. [S]; Mawn, Louise A. M.D., F.A.C.S. # (Source: Ophthalmic Plastic and Reconstructive Surgery)

Comparison of Vascularized Osteoperiosteal Femur Flaps and Nonvascularized Femur Grafts for Reconstruction of Mandibular Defects: An Experimental Study

Journal of Oral and Maxillofacial Surgery — Tue, 19 May 2009 17:02:06 +0100

Conclusions: The results of this study suggest that NVFGs have a greater bone resorption rate than do VFFs. Furthermore, the histomorphometric results imply that reconstruction of the mandibular defects with vascularized osteoperiosteal femur flaps will provide greater strength. (Source: Journal of Oral and Maxillofacial Surgery)

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[Peripheral occlusive arterial disease in the young patient.]

Presse Medicale — Sun, 10 May 2009 23:00:00 +0100

Authors: Constans J, Solanilla A, Boulon C, Conri C Lower limb arterial disease has unusual features when occurring before 50 years old. The most important one is the number of causes: atherosclerosis in 2/3 cases, Leo Buerger's disease in 1/4, but also sometimes embolic cardiopathies, antiphospholipid syndrome, myeloproliferative disorders, genetic or compressive diseases, inflammatory arterial disease. When peripheral arterial disease occurs before 50, explorations have to be performed according to anamnesis: duplex echography, EKG, blood sample. Afterwards other explorations may be performed such as other vascular imaging techniques, echocardiography or more complete biological investigation. Results from an ongoing multicenter study should be soon available and give more knowledge ...

Epidural Neurostimulation of Posterior Funiculi for the Treatment of Buerger's Disease

Neuromodulation — Mon, 20 Apr 2009 04:00:00 +0100

Conclusion. Neurostimulation of the posterior funiculi could be considered not only as palliative care but also as a therapeutic option. (Source: Neuromodulation)

Landmark Publication from The American Journal of the Medical Sciences, 'Thrombo-Angiitis Obliterans: A Study of the Vascular Lesions Leading to Presenile Spontaneous Gangrene'.

The American Journal of the Medical Sciences — Sat, 18 Apr 2009 04:48:31 +0100

Page: 274DOI: 10.1097/MAJ.0b013e31818c8bc9Authors: Buerger, Leo MD (Source: The American Journal of the Medical Sciences)

Buerger's Disease: Thromboangiitis Obliterans 100 Years After the Initial Description.

The American Journal of the Medical Sciences — Sat, 18 Apr 2009 04:48:31 +0100

Page: 285DOI: 10.1097/MAJ.0b013e318198d011Authors: Espinoza, Luis R. MD (Source: The American Journal of the Medical Sciences)

Leo Buerger (1879-1943) Revisited.

The American Journal of the Medical Sciences — Sat, 18 Apr 2009 04:48:31 +0100

Page: 287DOI: 10.1097/MAJ.0b013e318198d030Authors: Luft, Friedrich C. MD (Source: The American Journal of the Medical Sciences)

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CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification

Breast Cancer Research and Treatment — Tue, 07 Apr 2009 05:57:33 +0100

Abstract Overexpression and alternative splicing of CD44 have been implicated in tumour progression. Here we describe the identification of a high level amplification of human 11p13, encompassing the CD44 gene, in primary breast cancers and cell lines and test whether CD44 acts as the driver of this amplicon. aCGH analysis revealed 11p13 amplification in 3% (3/100) of primary breast carcinomas and in two cell lines. The minimal region of amplification was 34.38–37.62 Mb. Amplification was confirmed by dual-colour FISH in these cell lines and further validated by CISH in an independent tumour cohort. CD44 expression in primary breast cancers was significantly associated with features of basal-like breast cancer. Detection of CD44 expression in breast cancer cell lines...

Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial In Chennai India

Health News from Medical News Today — Thu, 02 Apr 2009 11:00:00 +0100

Harvest Technologies Corp. (http://www.harvesttech.com) announced that the interim study report was completed for the first thirty (30) patients in the clinical trial of patients suffering with non-reconstructable critical limb ischemia due to advanced thromboangitis obliterans, commonly referred to as Buerger's Disease. (Source: Health News from Medical News Today)

Leo Buerger (1879-1943) revisited.

The American Journal of the Medical Sciences — Tue, 31 Mar 2009 23:00:00 +0100

Authors: Luft FC PMID: 19365176 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)

Buerger's disease: thromboangiitis obliterans 100 years after the initial description.

The American Journal of the Medical Sciences — Tue, 31 Mar 2009 23:00:00 +0100

Authors: Espinoza LR PMID: 19365175 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)

Landmark publication from the American Journal of the Medical Sciences, 'Thrombo-angiitis obliterans: a study of the vascular lesions leading to presenile spontaneous gangrene'. 1908.

The American Journal of the Medical Sciences — Tue, 31 Mar 2009 23:00:00 +0100

Authors: Buerger L PMID: 19365174 [PubMed - indexed for MEDLINE] (Source: The American Journal of the Medical Sciences)

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Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers.

Clinical Cancer Research — Tue, 24 Mar 2009 04:00:00 +0100

CONCLUSIONS: Our results show the power of aCGH analysis in unraveling the genetic profiles of specific subgroups of cancer and for the identification of novel therapeutic targets. PMID: 19318498 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Streptococcal adhesion to various luting systems and the role of mixing errors.

Acta Odontologica Scandinavica — Mon, 23 Feb 2009 05:00:00 +0100

Conclusions. Various luting systems revealed considerable differences in their potential to adhere S. mutans. Variations from recommended cement proportions led to significant changes in the amount of adhering streptococci. PMID: 19235565 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)

Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMR.

Science Signaling — Sat, 31 Jan 2009 10:44:37 +0100

Authors: Marshall CB, Ho J, Buerger C, Plevin MJ, Li GY, Li Z, Ikura M, Stambolic V Tuberous sclerosis complex 2 (TSC2), whose gene is frequently mutated in tuberous sclerosis, increases the guanosine triphosphatase (GTPase) activity of the small heterotrimeric GTP-binding protein (G protein) Rheb, thus resulting in the decreased activity of the mammalian target of rapamycin (mTOR), the master regulator of cell growth. Here, we describe the development of a nuclear magnetic resonance (NMR)-based, quantitative, real-time assay to explore the molecular mechanism of the intrinsic and TSC2-catalyzed GTPase activity of Rheb. We confirmed that TSC2 accelerated GTP hydrolysis by Rheb 50-fold through an "asparagine-thumb" mechanism to substitute for the nonfunctional "catalytic" glutamine of R...

[Research Article] Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMR

Signal Transduction Knowledge Environment — Thu, 29 Jan 2009 04:54:23 +0100

An NMR-based assay enables real-time analysis of the GTPase activity of Rheb and of the effect of its GTPase-activating protein TSC2. (Source: Signal Transduction Knowledge Environment)

Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?

Genes, Chromosomes and Cancer — Tue, 20 Jan 2009 05:00:00 +0100

Loss of the long arm of chromosome 16 (16q) is observed in the vast majority of low grade/grade I (GI) invasive ductal carcinomas of no special type (IDC-NSTs), whereas this event is uncommonly seen in high grade/grade III (GIII) IDC-NSTs. Together with data on the pathology and genetics of breast cancer recurrences, this has led to the proposal that GI and GIII breast cancers evolve through distinct genetic pathways and that progression from GI to GIII is an unlikely biological phenomenon. We compared the genomic profiles of GIII-IDC-NSTs with 16q whole arm loss (16qWL) according to estrogen receptor (ER) status. 16qWL was found in 36.5% of cases and was significantly associated with ER expression and luminal phenotype. ER+ GIII-IDC-NSTs with 16qWL displayed significantly higher levels of...

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Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes

Cardiovascular Pathology — Fri, 09 Jan 2009 00:00:00 +0100

We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO). (Source: Cardiovascular Pathology)

Buerger's disease-like vasculitis associated with Kimura's disease

International Journal of Cardiology — Fri, 09 Jan 2009 00:00:00 +0100

Abstract: A 46-year-old man was first diagnosed as Buerger's disease according to his clinical and radiological features because he had no evidence of parasitic, allergic and connective tissue disease. Soft subcutaneous nodules suspected of lymphadenopathy on the bilateral inguinal regions were recognized after admission. Positron emission tomography scan showed the increased uptake of 18F-fluoro-2-deoxyglucose in the bilateral inguinal regions. We finally diagnosed him as Kimura's disease based on pathologic findings and laboratory data, and started steroid therapy. The uptake of 18F-fluoro-2-deoxyglucose disappeared and his leg pain was improved after the treatment. This is the first case report presenting a patient of Kimura's disease with Buerger's disease-like vasculitis who was demon...

Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes.

Cardiovascular Pathology — Wed, 07 Jan 2009 05:00:00 +0100

Buerger's disease-like vasculitis associated with Kimura's disease.

International Journal of Cardiology — Tue, 06 Jan 2009 05:00:00 +0100

Authors: Takaoka H, Takano H, Nakagawa K, Kobayashi Y, Hiroshima K, Komuro I A 46-year-old man was first diagnosed as Buerger's disease according to his clinical and radiological features because he had no evidence of parasitic, allergic and connective tissue disease. Soft subcutaneous nodules suspected of lymphadenopathy on the bilateral inguinal regions were recognized after admission. Positron emission tomography scan showed the increased uptake of (18)F-fluoro-2-deoxyglucose in the bilateral inguinal regions. We finally diagnosed him as Kimura's disease based on pathologic findings and laboratory data, and started steroid therapy. The uptake of (18)F-fluoro-2-deoxyglucose disappeared and his leg pain was improved after the treatment. This is the first case report presenting a patie...

The Role of Oxidative Stress and Antioxidant Defenses in Buerger Disease and Atherosclerotic Peripheral Arterial Occlusive Disease

Annals of Vascular Surgery — Tue, 06 Jan 2009 00:00:00 +0100

The aim of this study was to determine the status and the role of oxidative stress and antioxidant defenses in patients with Buerger disease and atherosclerotic peripheral arterial occlusive disease (PAOD). Seventy-three subjects resembling each other in general characteristics were involved in the study: 21 with lower extremity PAOD (mean age 53.05 ± 10.8 years, 17 men and four women), 22 with Buerger disease (mean age 38.59 ± 6.4 years, 19 men and three women), and 30 healthy volunteers (mean age 38.59 ± 6.4 years, 22 men and eight women). We measured the levels of plasma malondialdehyde (MDA), paraoxonase (PON1), protein carbonyls, arylesterase, nitric oxide (NO), serum oxidized low-density lipoprotein (ox-LDL) and MDA, glutathione (GSH), glutathione reductase (GSH-red), glutathione ...

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Cell Therapy in Peripheral Arterial Disease

Angiology — Mon, 15 Dec 2008 05:00:00 +0100

Management of advanced obstructive vascular disease affecting the extremities poses tremendous challenges for physicians and patients. Peripheral arterial disease is often a consequence of obstructive atherosclerosis affecting the ileofemoral circulation but is also rarely a result of nonatherosclerotic conditions such as thromboangiitis obliterans (Buerger's disease). Consequences range from the presence of asymptomatic obstruction to intermittent claudication, development of rest pain, ulceration, gangrene, and amputation. A relatively new and promising approach using cell therapy has recently been developed to treat intractable symptoms related to ischemia in subjects with peripheral arterial disease in whom conventional medical therapy and revascularization modalities have been exhaust...

Interactions of neutrophils with silver-coated vascular polyester grafts

Langenbeck's Archives of Surgery — Tue, 02 Dec 2008 07:32:33 +0100

Conclusion The results may indicate that silver-coated vascular polyester grafts activate neutrophils chronically which may favor tissue destruction and impaired antimicrobial effects. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00423-008-0439-7Authors Joerg Tautenhahn, University Hospital Department of General, Abdominal, and Vascular Surgery Leipziger Strasse 44 39120 Magdeburg GermanyFrank Meyer, University Hospital Department of General, Abdominal, and Vascular Surgery Leipziger Strasse 44 39120 Magdeburg GermanyThomas Buerger, University Hospital Department of General, Abdominal, and Vascular Surgery Leipziger Strasse 44 39120 Magdeburg GermanyUwe Schmidt, University Hospital Institute of Biostatistics Magdeburg GermanyHans Lippert, Universit...

Penile and scrotal involvement in Buerger's disease

Andrologia — Tue, 25 Nov 2008 05:00:00 +0100

We report a 47-year-old man with scrotal and penile necrosis. Partial penectomy, scrotal debridement and urethra-cutaneous anastomosis were performed. (Source: Andrologia)

Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4.

International Journal of Oncology — Sun, 23 Nov 2008 10:41:44 +0100

Authors: Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Buerger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H Wnt signalling regulates proliferation, self renewal and cell fate. Aberrant Wnt signalling is thought to contribute to AML pathogenesis by enhancing self renewal. Herein, we provide evidence for increased expression of Frizzled-4, a receptor for Wnt ligands, in primary AML blasts compared to normal bone marrow on the protein level. In addition, Frizzled-4 is highly expressed in human CD34 positive cells as well as in lineage negative sorted mouse bone marrow cells. Functionally, Frizzled-4 expression modulates apoptosis and enhances Wnt3a induced beta-catenin stability in myeloid progenitor cells. Frizzled-4-dependent beta-catenin stabiliza...

Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

BMC Cancer — Fri, 21 Nov 2008 05:00:00 +0100

Conclusions: The 14-gene signature is significantly associated with risk of distant metastasis. The signature has a predominance of proliferation genes which have prognostic significance above that of Ki-67 LI and may aid in prioritizing future mechanistic studies and therapeutic interventions. (Source: BMC Cancer)

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Chemical sympatholysis: indications, technique and complications.

British Journal of Hospital Medicine — Sat, 01 Nov 2008 04:00:00 +0100

Authors: Durai R, Hoque H Chemical sympatholysis is commonly performed for palmar or plantar hyperhidrosis, Buerger's disease, critical lower limb ischaemia where there is no revascularization option available and palliation of pain. The outcome varies from symptomatic improvement to failure, which may result in limb loss in the case of ischaemic limbs. PMID: 19069269 [PubMed - in process] (Source: British Journal of Hospital Medicine)

Grade I chondrosarcoma of bone: the Münster experience

Journal of Cancer Research and Clinical Oncology — Wed, 15 Oct 2008 10:50:46 +0100

In conclusion, intralesional resection of a grade I chondrosarcoma has a higher overall risk of local recurrence but is not associated with a poorer survival. This procedure can be recommended for stage I A tumours of the long bones of the extremities. However, in pelvic lesions it should be avoided because of a 100% recurrence rate. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-008-0486-zAuthors Arne Streitbürger, University Hospital of Münster Münster GermanyHelmut Ahrens, University Hospital of Münster Münster GermanyMaurice Balke, University Hospital of Münster Münster GermanyHorst Buerger, University Hospital of Münster Münster GermanyWinfried Winkelmann, University Hospital of Münster Münster GermanyGeorg Gosheger, University Hospital of Mün...

Buerger's disease

MayoClinic.com Full Feed — Sat, 20 Sep 2008 05:00:00 +0100

— Comprehensive overview covers symptoms of this disease that affects your blood vessels. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease

European Journal of Neurology — Thu, 18 Sep 2008 04:00:00 +0100

Conclusion: MMSE and CSF t-tau represent different aspects of disease severity. Whilst MMSE is closely related to impaired cerebral glucose metabolism, CSF t-tau is less closely related and appears to be less well suited for assessment of disease progression. (Source: European Journal of Neurology)

Streptococcal adhesion to novel low-shrink silorane-based restorative.

Dental Materials — Mon, 01 Sep 2008 04:00:00 +0100

Authors: Buergers R, Schneider-Brachert W, Hahnel S, Rosentritt M, Handel G OBJECTIVES: The aim of the present study was to compare the susceptibility of one novel silorane-based and four widely used conventional methacrylate-based resin composites to adhere oral streptococci and to relate any differences to surface roughness, hydrophobicity and type of matrix. METHODS: Specimens of restoratives Filtek Silorane, Filtek Z250, Tetric EvoCeram, Quixfil and Spectrum TPH were prepared (10.0-mm diameter, 2.0-mm height). Surface roughness was assessed by perthometer measurements and hydrophobicity according to water contact angles was determined by computerized image analysis. Bacterial suspensions of Streptococcus oralis, Streptococcus sanguinis, Streptococcus gordonii and Streptococcus muta...

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Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease

British Journal of Cancer AOP — Tue, 12 Aug 2008 04:00:00 +0100

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease British Journal of Cancer advance online publication, August 12, 2008. doi:10.1038/sj.bjc.6604556 Authors: M W Helms, D Kemming, H Pospisil, U Vogt, H Buerger, E Korsching, C Liedtke, C M Schlotter, A Wang, S Y Chan & B H Brandt (Source: British Journal of Cancer AOP)

Allelic imbalances of the egfr gene as key events in breast cancer progression--the concept of committed progenitor cells.

Current Cancer Drug Targets — Fri, 01 Aug 2008 04:00:00 +0100

Authors: Agelopoulos K, Buerger H, Brandt B The introduction of concepts proposing multiple cellular subgroups in the normal female breast leads to the hypothesis that distinct cellular phenotypes in the female breast give rise to different subtypes of breast carcinomas e.g. expressing ER, HER2 and EGFR differentially. Therefore, origin of breast carcinoma types may be based on the formation of a cancer prone field in which the committed progenitor cells pass mutations to their progenies, glandular as well as myoepithelial cells. The existence of such field within the human breast was inferred from the results on primary breast cancer obtained by PCR-based microsatellite analysis of allelic imbalance (AI) of the EGF receptor gene. Here, normal breast tissue shows egfr AI adjacent to br...

Spontaneous Compartment Syndrome: Hughes and Buerger Smoking.

Southern Medical Journal — Wed, 09 Jul 2008 09:32:46 +0100

Page: 685DOI: 10.1097/SMJ.0b013e31817c13f0Authors: Sanda, Robert B. MBBS, FRCSI (Source: Southern Medical Journal)

Compartment Syndrome in Patients with Buerger Disease and Anticardiolipin Antibodies.

Southern Medical Journal — Wed, 09 Jul 2008 09:32:46 +0100

We report two cases of acute compartment syndrome in the anterior compartment of the lower limbs of patients with Buerger disease associated with positive anticardiolipin antibodies. We comment on the rarity of the case and on the possibility of interference of two associated thrombogenic conditions. The need for early fasciotomy is emphasized since the progression to necrosis is time dependent. Fasciotomy was the only reperfusion surgery utilized on these patients with resolution of the ischemia.Page: 748DOI: 10.1097/SMJ.0b013e31817c13d2Authors: Pereira de Godoy, Jose Maria MD; Braile, Domingo Marcolino MD; Torres, Carlos Alexandre Andrade MD (Source: Southern Medical Journal)

Primary Hepatic Lymphoma of Mucosa-Associated Lymphoid Tissue Type: A Case Report With Cytogenetic Study

International Journal of Surgical Pathology — Sun, 22 Jun 2008 04:00:00 +0100

Primary hepatic lymphoma of mucosa-associated lymphoid tissue type is extremely rare. Only 38 cases have been reported to date. A case of a 59-year-old man with Helicobacter pylori—resistant gastric ulcers and Buerger disease who was followed up since 1999 is reported. A 2-cm hepatic nodule was incidentally found during partial gastrectomy and corresponded to mucosa-associated lymphoid tissue—type lymphoma without underlying liver disease. Molecular studies showed a clonal immunoglobulin heavy-chain gene rearrangement. Investigations for the mucosa-associated lymphoid tissue lymphoma-associated translocations t(11;18) and t(14;18), as well as the t(3;14)(q27;q32), were negative, whereas trisomy 3 and trisomy 18 were detected. (Source: International Journal of Surgical Pathology...

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Efficacy of denture disinfection methods in controlling Candida albicans colonization in vitro.

Acta Odontologica Scandinavica — Sun, 01 Jun 2008 04:00:00 +0100

CONCLUSIONS: Only soaking in sodium hypochlorite (1%; 10 min), microwave irradiation immersed in water (800 W; 6 min), and application of effervescent cleansing tabs (Blend-a-dent tabs; 10 min) proved to be effective against C. albicans colonization on soft denture relining material. PMID: 18568477 [PubMed - indexed for MEDLINE] (Source: Acta Odontologica Scandinavica)

[Superficial Migratory Thrombophlebitis: A Clinical and Histologic Review of 8 Cases.]

Actas Dermo-Sifiliograficas — Tue, 27 May 2008 18:37:14 +0100

CONCLUSION: The possible association of SMT with systemic diseases, including cancer, makes its diagnosis important. In our case series we did not find evidence of associated disease in the majority of cases. However, since cancer can manifest months and even years after the appearance of SMT, follow-up is necessary in these patients. PMID: 18501171 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Changes in angiogenesis-related factors in serum following autologous bone marrow cell implantation for severe limb ischemia

Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents — Thu, 15 May 2008 03:07:16 +0100

In this study, we investigated ... (Source: Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents)

Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas

Genes, Chromosomes and Cancer — Wed, 07 May 2008 04:00:00 +0100

Expression of EGFR in high grade osteosarcomas has been observed to be correlated with an improved prognosis. Yet, the underlying mechanism remained unclear since amplifications of EGFR have rarely been described. Recently, the length of a polymorphic CA repeat located at a 5[prime]-regulatory sequence in the intron 1 of the EGFR gene (SSR I) has been shown to be associated with its basal transcriptional activity. We therefore determined the allelic length of CA SSR-I in 219 cases of high grade osteosarcoma and correlated the results with EGFR expression in 34 cases, the presence of amplifications within the CA SSR-I repeat in 59 cases, and clinical follow-up. Our results confirm that in osteosarcoma patients short alleles are more frequent than longer ones, 16 CA repeats being the most fr...

Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41.

Gastroenterology — Thu, 01 May 2008 04:00:00 +0100

CONCLUSIONS: This study showed that the HCV peptide vaccine IC41 can induce HCV-specific Th1/Tc1 responses in a subset of difficult to treat HCV nonresponder patients despite persisting viremia. However, changes in HCV RNA occurred only in single patients. Because strongest T-cell responses were associated with HCV RNA decline, further studies with optimized vaccine regimens and combination therapies have been initiated. PMID: 18471515 [PubMed - in process] (Source: Gastroenterology)

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Painful digital infarction in a male smoker treated as Buerger's disease.

The Australasian Journal of Dermatology — Thu, 01 May 2008 04:00:00 +0100

Authors: Foley S, Gibbs H, Muir J A 40-year-old male smoker presented with a 3-week history of painful digital infarction involving the hands. Histology was unhelpful, showing lichen simplex chronicus. A provisional diagnosis of a vasculitic disease was made. Treatment included aspirin, azathioprine, iloprost, methylprednisolone, nifedipine and prednisolone. After failure of these treatments an alternative clinical diagnosis of Buerger's disease was made. Treatment was to advise the patient of the importance of continuing to abstain from smoking, to perform bilateral video-assisted thoracoscopic sympathectomies and to commence folate supplementation. This led to marked improvement of his symptoms and healing of the digital infarction. PMID: 18412809 [PubMed - indexed for MEDLINE] (...

[Reviews] Basal carcinoma of the breast revisited: an old entity with new interpretations

Journal of Clinical Pathology — Fri, 25 Apr 2008 04:00:00 +0100

The introduction of global gene expression analysis in breast cancer research has focused attention onto a repeatedly described subgroup of invasive breast cancer, the basal-like carcinomas. This subgroup is characterised by the expression of high-molecular weight cytokeratins 5, 14 and 17; using immunohistochemical diagnosis, it represents approximately 7–20% of invasive breast cancers. Some of these tumours fulfil the criteria of grade 3 invasive ductal carcinoma, the so-called triple negative carcinomas. However, other rare subgroups of metaplastic, medullary and myoepithelial carcinomas also belong to this entity. Even though the initial clinical prognostic relevance of basal-like breast cancers may have been overestimated, its distinctive biology generates many questions regardi...

En bloc spondylectomy in malignant tumors of the spine

European Spine Journal — Thu, 24 Jan 2008 17:03:44 +0100

Abstract En bloc spondylectomy is a technique that enables wide or marginal resection of malignant lesions of the spine. Both all posterior techniques as well as combined approaches are reported. Aim of the present study was to analyse the results of 21 patients with malignant lesions of the spine, all treated with en bloc excision in a combined posteroanterior (n = 19) or all posterior approach (n = 2). Twenty-one consecutive patients, operated between 1997 and 2005, were included into this retrospective study. Thirteen patients had primary malignant lesions, eight patients had solitary metastases, all located in the thoracolumbar spine. There were 16 single level, three two-level, one three-level and one four-level spondylectomy. The patients were follo...

Prostacyclin among prostanoids.

Pharmacological Reports — Tue, 01 Jan 2008 05:00:00 +0100

Authors: Gryglewski RJ Prostanoids are cyclic lipid mediators which arise from enzymic cyclooxygenation of linear polyunsaturated fatty acids, e.g. arachidonic acid (20:4 n 6, AA). Biologically active prostanoids deriving from AA include stable prostaglandins (PGs), e.g. PGE(2), PGF(2alpha), PGD(2), PGJ(2) as well as labile prostanoids, i.e. PG endoperoxides (PGG(2), PGH(2)), thromboxane A(2) (TXA(2)) and prostacyclin (PGI(2)). A "Rabbit aorta Contracting Substance" (RCS) played important role in discovering of labile PGs. RCS was discovered in the Vane's Cascade as a labile product released along with PGs from the activated lung or spleen. RCS was identified as a mixture of PG endoperoxides and thromboxane A(2). Stable PGs regulate the cell cycle, smooth muscle tone and various secret...

Effect of severity of sepsis on tissue concentrations of linezolid

Journal of Antimicrobial Chemotherapy — Mon, 17 Dec 2007 05:00:00 +0100

Conclusions These data indicated that the severity of sepsis has no substantial effect on the pharmacokinetic profile of linezolid in plasma and in the interstitium of soft tissues. (Source: Journal of Antimicrobial Chemotherapy)

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Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI

Neurology — Mon, 10 Dec 2007 05:00:00 +0100

Conclusions: An a priori defined cutoff value of p-tau231 yields relatively stable results across centers, suggesting a good feasibility of a standard criterion of p-tau231 for the prediction of Alzheimer disease. (Source: Neurology)

Corkscrew Collaterals in Thromboangitis Obliterans (Buerger's Disease).

Circulation — Tue, 20 Nov 2007 05:00:00 +0100

Authors: Fujii Y, Nishioka K, Yoshizumi M, Chayama K, Higashi Y PMID: 18025397 [PubMed - in process] (Source: Circulation)

[Retroperitoneoscopic excision of an adrenal cyst]

Aktuelle Urologie — Thu, 01 Nov 2007 04:00:00 +0100

CONCLUSIONS: The retroperitoneoscopic approach for symptomatic adrenal cyst resection represents an effective, cost-reducing and durable treatment. PMID: 17987537 [PubMed - indexed for MEDLINE] (Source: Aktuelle Urologie)

[Prognostic factors for critical limb ischemia after autologous bone marrow implantation]

Journal of Cardiology — Mon, 01 Oct 2007 04:00:00 +0100

CONCLUSIONS: Treatment with BMI could not save legs in some patients with ASO associated with severe leg ischemia. PMID: 17987839 [PubMed - indexed for MEDLINE] (Source: Journal of Cardiology)

No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's disease

Brain — Wed, 26 Sep 2007 04:00:00 +0100

(Source: Brain)

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Pharmacological treatment of Alzheimer's dementia: State of the art and current dilemmas.

The World Journal of Biological Psychiatry — Mon, 17 Sep 2007 04:00:00 +0100

Authors: Omerovic M, Hampel H, Teipel SJ, Buerger K Alzheimer's disease (AD) is one of the most frequent disorders of the central nervous system characterised by a progressive cognitive decline. The demographic changes of our aging population lead to increased numbers of patients and a need of early diagnosis and treatment of cognitive and behavioural symptoms of AD. Drugs are available for symptomatic treatment of AD. The pharmacological treatment of behavioural disturbances experienced dynamic changes in the last years. In this paper, we present the current state and future perspectives in the treatment of AD. Furthermore, we discuss current difficulties regarding AD treatment by looking for explanations for a still unsatisfying rate of state-of-the-art treatment of AD-patients. ...

À propos de la maladie de Buerger

Medecine et Chirurgie du Pied — Wed, 12 Sep 2007 07:23:35 +0100

R�sum� La maladie de Buerger ou thrombo-ang�ite oblit�rante (TAO) est une art�riopathie non ath�romateuse, il s’agit d’une entit� originale et sp�cifique. C’est une thrombo-ang�ite segmentaire affectant les art�res de moyen et de petit calibre et les veines des extr�mit�s des membres, touchant des jeunes adultes, essentiellement des hommes, fumeurs et qui �volue par pouss�es. Son diagnostic est difficile � affirmer avec certitude en l’absence de marqueurs sp�cifiques. Au plan th�rapeutique, l’arr�t total du tabac est la pierre angulaire de tout traitement auquel on peut associer des soins locaux. La chirurgie est une solution de dernier recours. L’avenir passe par la d�couverte de vasodilatateurs puissants et de facteurs sti...

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

Human Genetics — Thu, 26 Jul 2007 07:59:19 +0100

In this study, polymorphisms in HLA-DPB1, DRB1 and B were analyzed in 131 Japanese BD patients and 227 healthy controls. In addition, we investigated a functional promoter polymorphism, −260 C > T, of CD14 that is a main receptor of bacterial lipopolysaccharide. It was found that the frequencies of CD14 TT genotype [37.4 vs. 24.2%, P = 0.008 OR = 1.87, 95% confidence interval (CI); 1.18, 2.97], DRB1*1501 (34.4 vs. 13.2%, P c = 4.4 � 10−5, OR = 3.44, 95%CI; 2.06, 5.73) and DPB1*0501 (79.4 vs. 55.1%, P c = 4.7 � 10−5, OR = 3.14, 95%CI; 1.93, 5.11) were significantly higher in the patients than in the controls, demonstrating that at least three genetic markers were associated with ...

Frequent accelerated idioventricular rhythm in a young male of Buerger's disease with acute myocardial infarction.

International Journal of Cardiology — Wed, 13 Jun 2007 04:00:00 +0100

We reported a 32 year-old man with Buerger's disease (thromboangiitis obliterans) suffering from acute anterior chest pain and V(1-6) ST-segment elevation. Frequent episodes of accelerated idioventricular rhythm (AIVR) were found during initial admission. Emergent coronary angiography revealed thrombus inside the proximal left anterior descending coronary artery and primary percutaneous trasluminal coronary angioplasty and stenting was successfully done after thrombus aspiration. No more AIVR occurred after the procedure. Doctor should be alerted to AIVR as a sign of reperfusion in the acute coronary syndrome even in a young subject. PMID: 17574693 [PubMed - as supplied by publisher] (Source: International Journal of Cardiology)

Platelet Receptor HPA-1 Polymorphism of {alpha}IIb{beta}3 and 807 C/T Polymorphism of {alpha}2{beta}1 and Buerger's Disease

Angiology — Thu, 10 May 2007 04:00:00 +0100

Thromboangiitis obliterans or Buerger's disease is an episodic and segmental inflammatory and thrombotic process of the medium and small arteries of the lower extremities. Even though the disease was described 90 years ago, the etiopathogenesis is still under consideration. Afflicted patients are mostly young male cigarette smokers without signs of atherosclerosis or other risk factors for peripheral arterial occlusive disease. This indicates that hereditary thrombophilic factors could play a role in the etiopathogenesis. Recently, increasing evidence shows that platelet receptor polymorphisms (HPA-1 polymorphism of ß3 subunit of IIbß3 and 807 C/T polymorphism 2ß1) are associated with early onset of arterial thrombosis (myocardial infarction, stroke). This case-control st...

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Buerger Disease in an Elderly Man.

Southern Medical Journal — Sat, 05 May 2007 12:21:53 +0100

Buerger disease is diagnosed by keeping a high index of suspicion for the disease criteria, which include age less than 40 years, current or recent history of tobacco use, distal extremity ischemia, and exclusion of autoimmune and hypercoagulable diseases. The typical histopathological and angiographic findings are supportive of the diagnosis. In the current case, our patient met the criteria of Buerger disease except for the age criterion. Angiographic and histopathological evaluations, however, were supportive of the diagnosis.Page: 522DOI: 10.1097/01.smj.0000257640.68795.2eAuthors: Ismail, Hassan M. MD, MPH, FACP (Source: Southern Medical Journal)

Buerger's disease: Spinal cord stimulation may represent a useful tool for delaying amputation in young patients.

European Journal of Internal Medicine — Tue, 01 May 2007 04:00:00 +0100

Authors: Boari B, Salmi R, Manfredini R PMID: 17449407 [PubMed - in process] (Source: European Journal of Internal Medicine)

Local implantation of autologous mononuclear cells from bone marrow and peripheral blood for treatment of ischaemic digits in patients with connective tissue diseases

Rheumatology — Fri, 20 Apr 2007 04:00:00 +0100

Conclusions. Implantation of autologous MNCs from peripheral and bone marrow into the ischaemic digits was so effective in pain-relief and more clinical trials would be warranted to see whether this could be a new treatment modality for angiogenesis in connective tissue diseases as in Buerger's disease. (Source: Rheumatology)

Coronary Buerger's disease with a peripheral arterial aneurysm

European Heart Journal — Thu, 19 Apr 2007 04:00:00 +0100

(Source: European Heart Journal)

Thromboangiitis Obliterans (Buerger's Disease): Searching for a Therapeutic Strategy

Angiology — Fri, 09 Mar 2007 05:00:00 +0100

This article reviews the proposed therapeutic strategies and considers the advantages and disadvantages of each treatment. Cessation of smoking seems to be the only globally accepted therapeutic measure to prevent disease progression. A number of promising novel therapeutic strategies may prove useful for the treatment of this physically and socially mutilating disease. (Source: Angiology)

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A hernia in the inguinal region is not always an inguinal hernia

Hernia — Thu, 15 Feb 2007 07:58:31 +0100

We present this interesting case as a very rare complication of omentopexy, probably not reported previously, and an unusual case of an incisional hernia presenting as an inguinal hernia which is very difficult to diagnose unless encountered before. Its rarity and clinical challenge is highlighted. Content TypeJournal Article JournalHerniaOnline ISSN 1248-9204Print ISSN 1265-4906 (Source: Hernia)

The angiographic evaluation of lower-extremity arterial disease in the young adult

CardioVascular and Interventional Radiology — Thu, 08 Feb 2007 10:47:47 +0100

Abstract??The angiographic evaluation of 38 patients younger than 40 years of age with lower-extremity arterial disease is reviewed. Although atherosclerosis was the most common diagnosis, other etiologies included thromboembolism, popliteal artery entrapment, Buerger's disease, collagen vascular disease, and arteritis. The two features of the angiographic workup that proved most helpful in establishing an accurate diagnosis were biplane aortography and runoff exams designed to demonstrate possible popliteal artery entrapment. Content TypeJournal Article JournalCardioVascular and Interventional RadiologyOnline ISSN 1432-086XPrint ISSN 0174-1551 Journal VolumeVolume 8 Journal IssueVolume 8, Number 4 / August, 1985 (Source: CardioVascular and Interventional Radiology)

Pregnancy Complicated with Buerger's Disease.

Obstetric Anesthesia Digest — Mon, 05 Feb 2007 17:50:02 +0100

(Source: Obstetric Anesthesia Digest)

Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologist

Rheumatology — Mon, 22 Jan 2007 07:00:00 +0100

Thromboangiitis obliterans (Buerger's disease)—a type of vasculitis in young, mostly male subjects—remains strangely linked to smoking, which determines its occurrence, progression and prognosis by currently unknown mechanisms. It affects the small and medium-sized arteries and veins of the limbs. Despite the usual absence of systemic signs and symptoms, initially intermittent arthritis, even if not observed in all cases, confer on this disease the status of a systemic vasculitis. Diagnosis requires the elimination of many other diseases. The severity of the disease lies in the need for amputation in more than a quarter of all patients. Complete cessation of smoking remains the cornerstone of therapy. Local care is the second essential element of treatment. Prostacycline analog...

[Medical_Sciences] Protective effects of exercise and phosphoinositide 3-kinase(p110{alpha}) signaling in dilated and hypertrophic cardiomyopathy

Proceedings of the National Academy of Sciences — Tue, 09 Jan 2007 07:00:00 +0100

Physical activity protects against cardiovascular disease, and physiological cardiac hypertrophy associated with regular exercise is usually beneficial, in marked contrast... (Source: Proceedings of the National Academy of Sciences)

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Egfr amplification specific gene expression in phyllodes tumours of the breast.

Cellular Oncology — Mon, 01 Jan 2007 05:00:00 +0100

CONCLUSION: Our results show that amplifications within regulatory sequences of egfr are associated with the expression of eps15 and caveolin-1, indicating an increased turnover of EGFR. The interplay between EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK therefore seems to present a major molecular pathway in carcinogenesis and progression of breast phyllodes tumours. PMID: 18032821 [PubMed - indexed for MEDLINE] (Source: Cellular Oncology)

CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

Brain — Fri, 27 Oct 2006 06:00:00 +0100

Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was d...

Stromelysin-1 5A/6A and eNOS T-786C Polymorphisms, MTHFR C677T and A1298C Mutations, and Cigarette-Cannabis Smoking: A Pilot, Hypothesis-Generating Study of Gene-Environment Pathophysiological Associations With Buerger's Disease

Clinical and Applied Thrombosis/Hemostasis — Mon, 25 Sep 2006 06:00:00 +0100

Buerger’s disease (BD) etiologies are poorly understood. Beyond smoking cessation, medical-surgical treatments have limited success. We hypothesized that mutations associated with arterial vasospasm (stromelysin-1 5A/6A, eNOS T-786C) and C677T-A1298C methylene tetrahydrofolate reductase (MTHFR) interacted with cigarette-cannabis smoking, reducing vasodilatory nitric oxide (NO), promoting arterial spasm-thrombosis. Of 21 smoking BD patients (14 men [2 siblings], 7 women; 20 white, 1 African-American), compared to 21 age-gender-race matched healthy controls, 5A/6A stromelysin- 1 homozygosity was present in 7 of 21 (33%) BD cases versus 5 of 21 (24%) controls (risk ratio 1.4; 95% confidence interval [CI] 0.5-3.7), and eNOS T-786C homozygosity was present in 3 of 21 (14%) BD cases versus...

Office evaluation of lacrimal and orbital disease.

Otolaryngologic clinics of North America — Thu, 21 Sep 2006 04:28:02 +0100

Authors: Zaldívar RA, Buerger DE, Buerger DG, Woog JJ PMID: 16982254 [PubMed - in process] (Source: Otolaryngologic clinics of North America)

High incidence of metastatic disease in primary high grade and large extremity soft tissue sarcomas treated without chemotherapy

BMC Cancer — Sun, 18 Jun 2006 06:00:00 +0100

Conclusions: Without chemotherapy there remains a high risk of metastasis in AJCC grade 3 patients. In high risk patients treated without chemotherapy the elapsed time to tumour resection after preoperative radiation might contribute to the development of metastasis. This outcome may support the thesis that a combination of RTX and offensive multimodal treatment protocols is advantageous in such a subset of patients. (Source: BMC Cancer)

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[Miscellanea] Corkscrew appearance in the right coronary artery in a patient with Buerger's disease

Heart — Wed, 14 Jun 2006 06:00:00 +0100

(No abstract is available for this citation) (Source: Heart)

Peripheral Arterial Disease: Thromboangiitis Obliterans

Medscape Cardiology Headlines — Thu, 08 Jun 2006 06:00:00 +0100

Thromboangiitis obliterans is a vasculitis that is also known as Buerger disease.ACP Medicine Reference (Source: Medscape Cardiology Headlines)

[Original articles] Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas

Journal of Clinical Pathology — Fri, 26 May 2006 06:00:00 +0100

Conclusions: Frequency of EGFR immunopositivity in STS strongly depends on the antibody used, and only one of five antibodies tested predicted an unfavourable clinical outcome. This indicates that choice of primary antibody and scoring system have a substantial impact on the determination of EGFR immunoreactivity. (Source: Journal of Clinical Pathology)

Systemic lupus erythematosis with antiphospholipid antibody syndrome: A mimic of Buergers disease

Journal of Postgraduate Medicine — Sat, 20 May 2006 06:00:00 +0100

Vasugi Zoya, Danda DJournal of Postgraduate Medicine 2006 52(2):132-133This case report is about a past smoker who presented with history of recurrent ulcers and digital gangrene with claudication pain of the left foot for the past fifteen years. Clinical examination and angiogram showed disease involving the peripheral vessels of lowervlimb. This patient had been labeled as Buergers disease 15 years ago based on clinical and demographic profile of the illness. We felt that the progression of the disease despite the patient having stopped smoking 15 years ago along with the presence of elevated inflammatory markers in the blood with proteinuria was not in keeping with the nature of the disease. Furthur evaluation revealed that the patient had systemic lupus erythematosus with antiphospholi...

Diagnostic Criteria and Treatment of Buerger's Disease: A Review

The International Journal of Lower Extremity Wounds — Fri, 12 May 2006 06:00:00 +0100

Buerger’s disease is an inflammatory occlusive disorder affecting the small and medium-size arteries and veins of young, predominately male, smokers. The disorder has been identified as an autoimmune response triggered when nicotine is present. Tobacco abuse is the major contributing risk factor; however, smoking seems to be a synergistic factor rather than the cause of the disease. The traditional diagnosis of Buerger’s disease is based on 5 criteria (smoking history, onset before the age of 50 years, infrapopliteal arterial occlusive disease, either upper limb involvement or phlebitis migrans, and absence of atherosclerotic risk factors other than smoking). As there is no specific diagnostic test and an absence of positive serologic markers, confident clinical diagnosis shoul...

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Endothelial dysfunction in Buerger's disease and its relation to markers of inflammation

European Journal of Clinical Investigation — Mon, 08 May 2006 15:44:41 +0100

European Journal of Clinical Investigation Volume 36, Issue 6, Page 376-382, Jun 2006 (Source: European Journal of Clinical Investigation)

[Sub acute ischemia of a lower limb in a patient with juvenile peripheral arterial disease and arterial cocaine toxicity]

Journal des Maladies Vasculaires — Mon, 01 May 2006 04:00:00 +0100

This report highlights the combined arterial toxicity of drugs often used together by drug addicts. The association of cannabis use and tobacco smoking is not rare in patients with Buerger-like juvenile arteriopathy and cocaine may provoke peripheral vascular disease by embolism or in situ thrombosis. Interrogation of a patient presenting with Buerger-like peripheral arterial disease should insist on detecting use of drugs in association with tobacco smoking. PMID: 16733438 [PubMed - indexed for MEDLINE] (Source: Journal des Maladies Vasculaires)

A Prospective, Case-control Study of Tobacco Dependence in Thromboangiitis Obliterans (Buerger's Disease)

Angiology — Sun, 01 Jan 2006 07:00:00 +0100

Thromboangiitis obliterans (TAO) is often cited as an extreme phenotype of vasculopathy and tobacco dependence. Although tobacco exposure is essential to progression of arterial ischemia in TAO, expert opinion differs regarding the degree of tobacco dependence in this population. The authors designed a prospective, case-control study to test the hypothesis that subjects with TAO have a greater degree of tobacco dependence than control subjects with coronary atherosclerosis (coronary artery disease [CAD]) do. Subjects with TAO (n=218, confirmed by angiography, biopsy, or noninvasive arterial testing) or CAD (n=343, diagnosed by coronary angiography) were mailed a standardized questionnaire regarding tobacco use, to which 103 and 273 responded, respectively. The degree of tobacco dependence ...

The Prostacyclin Analog, Treprostinil Sodium, Provides Symptom Relief in Severe Buerger's Disease: A Case Report and Review of Literature

Angiology — Sun, 01 Jan 2006 07:00:00 +0100

Buerger’s disease (thromboangiitis obliterans or TAO) is a clinical syndrome characterized by the development of segmental thrombotic occlusions of the medium and small arteries. The primary treatment for Buerger’s disease is cessation of cigarette smoking. In patients whose disease progresses despite smoking cessation, therapeutic options are limited. Revascularization is rarely indicated and usually not successful because of the diffuse and distal distribution of the disease. Prostacyclin, or PGI2, and its analogs have been proposed as pharmacotherapy for Buerger’s disease and studied in Europe. The authors review the prostacyclin literature in the treatment of Buerger’s disease and present a case report of a patient with progressive Buerger’s disease and th...

The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy.

Cellular Oncology — Sun, 01 Jan 2006 05:00:00 +0100

Authors: Mikesch JH, Schier K, Roetger A, Simon R, Buerger H, Brandt B Decay-accelerating factor (DAF, CD55) is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. Here DAF seems to exert different functions beyond its immunological role such as e.g. promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility, and metastasis via oncogenic tyrosine kinase pathways and specific seven-span transmembrane receptors (CD97) binding. Therefore, DAF has already become a target for therapy. In this paper we review the role of DAF in human malignancies as described in different basic, diagnostic and experimental t...

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Successful Intravenous Regional Sympathetic Blockade (Bier's Block) with Guanethidine and Lidocaine in a Patient with Advanced Buerger's Disease (Thromboangiitis Obliterans): A Case Report

Angiology — Fri, 01 Jul 2005 06:00:00 +0100

A 65-year-old man, a heavy smoker with Buerger's disease (thromboangiitis obliterans), presented to this department with persistent severe ischemic rest pain at the fingers of his right hand, not responding to oral treatment with vasodilators and analgesics. Critical blood flow was discovered in the middle, ring, and little finger, with ischemic ulcerations apparent in the fingertips of these 3 fingers. The distal phalanx of the little finger had been amputated 6 months before because of gangrenous necrosis. In an attempt to avoid further disabling amputations, the patient received 3 series of Bier's block sessions with guanethidine and lidocaine according to a specific protocol. Marked increase in finger blood flow was induced even after the first series, and complete disappearance of bot...