MedWorm: Chronic Pain

Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury

Advances in Pharmacological Sciences — Wed, 08 Feb 2012 18:37:00 +0100

In this study, we investigated the effects of yokukansan on neuropathic pain in chronic constriction injury (CCI) model. Oral administration of yokukansan significantly inhibited mechanical and cold allodynia in the von Frey hair or acetone test, respectively. In comparison, amitriptyline, a tricyclic antidepressant, demonstrated moderate, but not significant, antiallodynic effects in the mechanical and cold tests. Yokukansan significantly inhibited the cerebrospinal fluid dialysate level of glutamate that had increased by the stimulation of brush or acetone. Glutamate transporter inhibitors, DL-threo-beta-hydroxy aspartate and dihydrokainate, decreased the yokukansan-induced antiallodynic actions in CCI rats. Our results suggest that yokukansan was confirmed to have antiallodynic effects ...

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Atypical facial pain related to apical fenestration and overfilling

International Endodontic Journal — Wed, 08 Feb 2012 16:25:28 +0100

Pasqualini D, Scotti N, Ambrogio P, Alovisi M, Berutti E. Atypical facial pain related to apical fenestration and overfilling. International Endodontic JournalAbstractAim To report a case of apical fenestration and overfilling in which unusual pain characteristics made differential diagnosis challenging.Summary A 32‐year‐old woman with diffuse, spontaneous, moderate pain in the maxillary left posterior sector, exacerbated by masticatory and facial muscle movement, with intense sporadic electric‐shooting pain, underwent clinical examination and 3D cone beam computed tomography (CBCT). Apical fenestration with protrusion of the mesial root of tooth 26 beyond the buccal cortical plate, extrusion of canal filling material into the soft tissues and a periosteal reaction were detecte...

Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis

Anesthesiology Research and Practice — Wed, 08 Feb 2012 12:16:29 +0100

We present here a technical approach for the isolation and preservation of the islets proven to be efficient to obtain high numbers of islets, favoring the successful treatment of young patients. (Source: Anesthesiology Research and Practice)

Hope For Effective Endometriosis Screening Following Gene Mutation Discovery

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

Researchers at Yale School of Medicine have, for the first time, described the genetic basis of endometriosis, a condition affecting millions of women that is marked by chronic pelvic pain and infertility. The researchers' discovery of a new gene mutation provides hope for new screening methods. Published in the early online issue of EMBO Molecular Medicine, the study explored an inherited mutation located in part of the KRAS gene, which leads to abnormal endometrial growth and endometrial risk... (Source: Health News from Medical News Today)

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia

Glia — Wed, 08 Feb 2012 05:00:00 +0100

AbstractP2X4 ATP‐gated cation channels have been shown to contribute to the microglial component of central sensitization, making their functional regulation a key element in chronic pain pathologies. Here we show that prolonged activation of native P2X4 receptor channels by ATP induces opening of a pore permeable to NMDG+ and large fluorescent dyes in BV‐2 microglial cells and primary murine microglia. This intrinsic pore formation mechanism is potentiated by LPS treatment, known to upregulate P2X4 expression in microglial cells and to mimic the microglial activation observed in neuropathic pain states. Sustained activation of the P2X7 channel subtype, also expressed in microglia, induces a pore formation that requires pannexin hemichannels and leads to plasma membrane blebbing and cy...

Symptom-specific associations between low cortisol responses and functional somatic symptoms: The TRAILS study

Psychoneuroendocrinology — Tue, 07 Feb 2012 14:13:24 +0100

Conclusion: Two clusters of FSS are differentially associated with the stress hormone cortisol. (Source: Psychoneuroendocrinology)

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Insomnia

MedicineNet Chronic Pain General — Tue, 07 Feb 2012 07:00:00 +0100

Title: InsomniaCategory: Diseases and ConditionsCreated: 6/6/2005Last Editorial Review: 2/7/2012 (Source: MedicineNet Chronic Pain General)

Addressing Both Depression and Pain in Late Life: The Methodology of the ADAPT Study

Pain Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions. The results of this trial will inform the care of these complex patients and further understanding of comorbid pain and depression in late life. (Source: Pain Medicine)

Does This Patient Have an Infection of a Chronic Wound? [The Rational Clinical Examination]

JAMA — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions The presence of increasing pain may make infection of a chronic wound more likely. Further evidence is required to determine which, if any, type of quantitative swab culture is most diagnostic. (Source: JAMA)

Health Economics of Interdisciplinary Rehabilitation for Chronic Pain: Does it Support or Invalidate the Outcomes Research of These Programs?

Current Pain and Headache Reports — Mon, 06 Feb 2012 19:34:33 +0100

Abstract Interdisciplinary rehabilitation has been shown to be effective for treatment of patients suffering from chronic nonmalignant pain with respect to activity level, pain intensity, function, or days of sick leave. However, effects in clinical outcome do not necessarily imply a superiority of the intervention from an economic point of view. Despite an increasing number of cost-utility and cost-effectiveness studies, systematic reviews outline the methodological heterogeneity of studies, which makes it impossible to perform meta-analyses and to draw conclusions from the studies. Recent publications add interesting information to the current discussion; these studies cover the long-term development of sickness absence post-intervention and the cost effectiveness of wor...

Depressive Symptoms, Chronic Pain, and Falls in Older Community-Dwelling Adults: The MOBILIZE Boston Study. - Eggermont LH, Penninx BW, Jones RN, Leveille SG.

SafetyLit: All (Unduplicated) — Mon, 06 Feb 2012 11:54:53 +0100

OBJECTIVES: To examine whether overall depressive symptoms and symptom clusters are associated with fall risk and to determine whether chronic pain mediates the relationship between depression and fall risk in aging. DESIGN: Prospective cohort study. SETTI... (Source: SafetyLit: All (Unduplicated))

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Map Shows Where in U.S. to Beware of Lyme Disease

MedicineNet Chronic Pain General — Mon, 06 Feb 2012 07:00:00 +0100

Title: Map Shows Where in U.S. to Beware of Lyme DiseaseCategory: Health NewsCreated: 2/3/2012 6:06:00 PMLast Editorial Review: 2/6/2012 (Source: MedicineNet Chronic Pain General)

Gene mutation discovery sparks hope for effective endometriosis screening

EurekAlert! - Social and Behavioral Science — Mon, 06 Feb 2012 05:00:00 +0100

(Yale University) Researchers at Yale School of Medicine have, for the first time, described the genetic basis of endometriosis, a condition affecting millions of women that is marked by chronic pelvic pain and infertility. The researchers' discovery of a new gene mutation provides hope for new screening methods. (Source: EurekAlert! - Social and Behavioral Science)

Best Mattress for People With Arthritis

About.com Eating Disorders — Mon, 06 Feb 2012 05:00:00 +0100

A comfortable mattress is extremely important to someone living with chronic arthritis pain. Finding the best mattress can be somewhat of a challenge though. After all, it is a matter of personal choice. (Source: About.com Eating Disorders)

MRI and arthroscopy correlations of the hip: a case-based approach.

Pain Physician — Sun, 05 Feb 2012 17:36:02 +0100

Authors: McCall DA, Safran MR Abstract Disorders of the hip joint can be physically disabling for the patient and a diagnostic challenge for the physician. Advances in imaging the hip with MRI can help the physician determine a more specific diagnosis for patients with acute or chronic hip pain. MRI and particularly magnetic resonance arthrography have helped raised awareness of nonarthritic hip problems and have made the diagnosis of hip problems much easier. Intra-articular and extra-articular processes can be evaluated with MRI; multiple sequences are available to increase the sensitivity and specificity for detecting specific pathology around the hip. Because the hip is a deep joint within a large soft-tissue envelope, MRI more precisely delineates the sources of hip pain by ev...

Low back pain in 17 year olds has substantial impact and represents an important public health disorder: a cross-sectional study

BMC Public Health - Latest articles — Sun, 05 Feb 2012 05:00:00 +0100

Conclusion: LBP, and particularly chronic LBP, has a significant negative impact at 17 years. It is commonly associated with care seeking, medication use, school absenteeism, and reduced HRQOL. These findings support that adolescent LBP is an important public health issue that requires attention. (Source: BMC Public Health - Latest articles)

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A Comprehensive Review of Telehealth for Pain Management: Where We Are and The Way Ahead

Pain Practice — Sun, 05 Feb 2012 05:00:00 +0100

AbstractPain is generally undertreated in the United States, owing to a number of barriers including geographic distance from specialty treatment providers; functional disability that limits mobility; treatment‐related stigma; economic limitations; and educational barriers. Pain undertreatment exacerbates pain chronicity and emotional disruption that can significantly erode a pain patient’s quality of life, and there is widespread agreement that pain care must evolve to address this significant problem. The growing field of telehealth (defined for the purposes of this paper as technology that allows for distance interaction between providers and/or patients) offers a novel opportunity to expand pain assessment, consultation, and treatment services beyond the walls of the specialty pain...

The Long‐Term Outcome of Transcutaneous Electrical Nerve Stimulation in the Treatment for Patients with Chronic Pain: A Randomized, Placebo‐Controlled Trial

Pain Practice — Sun, 05 Feb 2012 05:00:00 +0100

Conclusions: Transcutaneous electrical nerve stimulation and sham TENS show similar effects in patients with chronic pain over a period of 1 year. We found support for a long sustained placebo effect. (Source: Pain Practice)

Use and Costs of Prescription Medications and Alternative Treatments in Patients with Osteoarthritis and Chronic Low Back Pain in Community‐Based Settings

Pain Practice — Sun, 05 Feb 2012 05:00:00 +0100

Conclusions: Patients with OA and CLBP used a variety of pain‐related and adjunctive medications. Although, alternative treatments are widely recommended, we found limited use of several of these in clinical practice, potentially due to the source of our data (commercial claims). Further research is needed to ascertain the extent to which such therapies contribute to the total costs of OA and CLBP management. (Source: Pain Practice)

[Seminar] Non-specific low back pain

LANCET — Sat, 04 Feb 2012 05:00:00 +0100

Non-specific low back pain has become a major public health problem worldwide. The lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of chronic low back pain is about 23%, with 11–12% of the population being disabled by low back pain. Mechanical factors, such as lifting and carrying, probably do not have a major pathogenic role, but genetic constitution is important. History taking and clinical examination are included in most diagnostic guidelines, but the use of clinical imaging for diagnosis should be restricted. (Source: LANCET)

New Heart Failure Risks: Fractures and Memory Problems

MedicineNet Chronic Pain General — Fri, 03 Feb 2012 07:00:00 +0100

Title: New Heart Failure Risks: Fractures and Memory ProblemsCategory: Health NewsCreated: 2/3/2012 11:01:00 AMLast Editorial Review: 2/3/2012 (Source: MedicineNet Chronic Pain General)

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PAINWeek 2012: Ready to Address the Epidemic of Chronic Pain

PRWeb: Medical Pharmaceuticals — Fri, 03 Feb 2012 06:24:02 +0100

Challenges cited in the 2011 Institute of Medicine (IOM) report and the recent NEJM article have made PAINWeek the largest US pain conference for frontline practitioners.(PRWeb January 31, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9145505.htm (Source: PRWeb: Medical Pharmaceuticals)

Horizon scanning: Lubiprostone meets primary endpoint for the treatment of opioid induced bowel dysfunction in phase 3 study

NeLM - News — Fri, 03 Feb 2012 05:00:00 +0100

Source: BioSpace Area: News BioSpace reports that a drug under development for opioid induced bowel dysfunction (OBD) - lubiprostone - met its primary endpoint in a phase 3 clinical trial in patients with chronic, non-cancer pain, excluding those taking methadone. Lubiprostone is a chloride channel activator that is licensed in the United States for the treatment of chronic idiopathic constipation (CIC) in adults and for irritable bowel syndrome with constipation (IBS-C) in women 18 years of age and older. Patients enrolled in the phase 3, randomised, double blind, placebo controlled study received lubiprostone 24-mcg capsule or placebo capsule twice daily for 12 weeks. The primary endpoint was the overall spontaneous bowel movement (SBM) response rate. The response rate for lubiprostone...

Psychosocial aspects of temporomandibular disorders and oral health-related quality-of-life.

Acta Odontologica Scandinavica — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions. TMD associate with OHRQoL through multiple ways, linked with depression and somatization. These findings emphasize the importance of early and effective treatment of TMD. PMID: 22300221 [PubMed - as supplied by publisher] (Source: Acta Odontologica Scandinavica)

OBD drug meets Phase 3 trial primary endpoint: Sucampo, Takeda

Drug Development Technology — Fri, 03 Feb 2012 00:00:00 +0100

Sucampo Pharmaceuticals (SPI) and Takeda Pharmaceuticals have announced the results from the Phase 3 clinical trial of lubiprostone as a treatment of opioid-induced bowel dysfunction (OBD) in patients with chronic, non-cancer pain, excluding those ta… (Source: Drug Development Technology)

Antioxidants and Chronic Pancreatitis: Theory of Oxidative Stress and Trials of Antioxidant Therapy

Digestive Diseases and Sciences — Thu, 02 Feb 2012 18:09:14 +0100

Abstract Chronic pancreatitis (CP) is an inflammatory disease characterized by the progressive destruction of pancreatic tissue and resulting in pancreatic exocrine and endocrine insufficiency. Increased oxidative stress has been implicated as a potential mechanism in its etiology and pathology. A number of studies have demonstrated that CP patients have a compromised antioxidant status, which may be a contributing factor to the enhanced oxidative state associated with the disease. Nutrition is an essential consideration in the treatment of CP, especially since diet is a source of several antioxidants and cofactors required for the production of cellular antioxidant enzymes. Many CP patients have an inadequate intake of macro and micronutrients because of abdominal pain an...

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Researchers Develop Novel Drug Delivery System

Health News from Medical News Today — Thu, 02 Feb 2012 08:00:00 +0100

Long duration, controllable drug delivery is of wide interest to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery. Now a team of researchers led by Boston University Biomedical Engineer and Chemist Mark Grinstaff has developed a unique material and drug delivery mechanism that could pave the way for implants that release a drug at a designated rate for months... (Source: Health News from Medical News Today)

infliximab, Remicade

MedicineNet Chronic Pain General — Thu, 02 Feb 2012 07:00:00 +0100

Title: infliximab, RemicadeCategory: MedicationsCreated: 12/13/1999 9:40:00 PMLast Editorial Review: 2/2/2012 (Source: MedicineNet Chronic Pain General)

Gleevec Approval Widened to Include Rare Cancer

MedicineNet Chronic Pain General — Thu, 02 Feb 2012 07:00:00 +0100

Title: Gleevec Approval Widened to Include Rare CancerCategory: Health NewsCreated: 2/1/2012 4:06:00 PMLast Editorial Review: 2/2/2012 (Source: MedicineNet Chronic Pain General)

Health Tip: Help Prevent a Stress Fracture

MedicineNet Chronic Pain General — Thu, 02 Feb 2012 07:00:00 +0100

Title: Health Tip: Help Prevent a Stress FractureCategory: Health NewsCreated: 2/2/2012 8:05:00 AMLast Editorial Review: 2/2/2012 (Source: MedicineNet Chronic Pain General)

Long-term Results of Surgical Decompression of Chronic Exertional Compartment Syndrome of the Forearm in Motocross Racers

The American Journal of Sports Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion: Surgical fasciotomy and fasciectomy of the forearm flexor compartment are equally successful in motocross racers suffering from forearm CECS. (Source: The American Journal of Sports Medicine)

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Cerebral Blood Flow Dynamics During Pain Processing Investigated by Functional Transcranial Doppler Sonography

Pain Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions. The findings suggest that fTCD measurements prove sensitive both to different levels of physical intensity of painful stimuli and to interindividual differences in nociceptive responding. fTCD may be a valuable tool in clinical pain research, for instance, when it comes to quantifying the temporal dynamics of exaggerated nociceptive responses in chronic pain, or evaluating treatment effects on nociceptive processing. (Source: Pain Medicine)

Use of non-steroidal anti-inflammatory drugs in pregnancy: impact on the fetus and newborn.

Current Drug Metabolism — Thu, 02 Feb 2012 05:00:00 +0100

This article discusses in detail the placental transfer and metabolism of NSAIDs, and the adverse impact of prenatal NSAID exposure on the offspring. PMID: 22299823 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)

Pelvic Inflammatory Disease: Current Concepts of Diagnosis and Management

Current Infectious Disease Reports — Wed, 01 Feb 2012 17:11:35 +0100

Abstract Pelvic inflammatory disease (PID), one of the most common infections in non-pregnant women of reproductive age, remains an important public health problem. It is associated with major long-term sequelae, including tubal factor infertility, ectopic pregnancy, and chronic pelvic pain. In addition, treatment of acute PID and its complications incurs substantial health care costs. Prevention of these long-term sequelae is dependent upon clinicians having a high index of suspicion in order to make an early diagnosis and development of treatment strategies based on knowledge of the microbiologic etiology of acute PID. It is well accepted that acute PID is a polymicrobic infection. The sexually transmitted organisms, Neisseria gonorrhoeae and Chlamydia trachomatis, are pr...

Nonsteroidal Anti-inflammatory Drugs and Ulcers

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Nonsteroidal Anti-inflammatory Drugs and UlcersCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

Coping With Chronic Rheumatic Diseases

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Coping With Chronic Rheumatic DiseasesCategory: Doctor's ViewsCreated: 8/4/2000 3:27:00 PMLast Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

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Arthritis - Whether Weather Affects Arthritis

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Arthritis - Whether Weather Affects ArthritisCategory: Doctor's ViewsCreated: 9/10/2000Last Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

Rheumatoid Arthritis: Questions for Your Doctor

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Rheumatoid Arthritis: Questions for Your DoctorCategory: Doctor's ViewsCreated: 8/6/2001 4:16:00 PMLast Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

Pain (Acute and Chronic)

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Pain (Acute and Chronic)Category: Doctor's ViewsCreated: 11/30/2004Last Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

Heartburn Drugs Linked to Hip Fractures in Women

MedicineNet Chronic Pain General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Heartburn Drugs Linked to Hip Fractures in WomenCategory: Health NewsCreated: 2/1/2012 11:01:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Chronic Pain General)

Pain (Acute and Chronic)

MedicineNet Senior Health General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Pain (Acute and Chronic)Category: Doctor's ViewsCreated: 11/30/2004Last Editorial Review: 2/1/2012 (Source: MedicineNet Senior Health General)

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Long‐Term Effect of Pulsed Radiofrequency on Chronic Cervical Radicular Pain Refractory to Repeated Transforaminal Epidural Steroid Injections

Pain Medicine — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion. Application of PRF to the DRG appears to be an effective and relatively safe intervention technique for chronic cervical radicular pain refractory to repeated TFESIs. (Source: Pain Medicine)

The Impact of Sexual or Physical Abuse History on Pain‐Related Outcomes among Blacks and Whites with Chronic Pain: Gender Influence

Pain Medicine — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions. Our study confirms physical and mental health, and pain‐related outcomes are affected by abuse history for men and women. These results support screening all patients for abuse to improve the survivor's overall health and well‐being. (Source: Pain Medicine)

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Pediatric Analgesic Clinical Trial Designs, Measures, and Extrapolation: Report of an FDA Scientific Workshop

PEDIATRICS — Wed, 01 Feb 2012 05:00:00 +0100

Analgesic trials pose unique scientific, ethical, and practical challenges in pediatrics. Participants in a scientific workshop sponsored by the US Food and Drug Administration developed consensus on aspects of pediatric analgesic clinical trial design. The standard parallel-placebo analgesic trial design commonly used for adults has ethical and practical difficulties in pediatrics, due to the likelihood of subjects experiencing pain for extended periods of time. Immediate-rescue designs using opioid-sparing, rather than pain scores, as a primary outcome measure have been successfully used in pediatric analgesic efficacy trials. These designs maintain some of the scientific benefits of blinding, with some ethical and practical advantages over traditional designs. Preferred outcome measures...

Prediction of Failure to Retain Work 1 Year After Interdisciplinary Functional Restoration in Occupational Injuries

Archives of Physical Medicine and Rehabilitation — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: This study identified demographic, psychosocial, and occupational factors that were predictive of failure to retain work. These risk factors may be used to individualize treatment plans for CDOMD patients in order to provide optimal functional restoration. (Source: Archives of Physical Medicine and Rehabilitation)

Multifidus Atrophy Is Localized and Bilateral in Active Persons With Chronic Unilateral Low Back Pain

Archives of Physical Medicine and Rehabilitation — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: The results of this study indicate that despite a low level of disability and an activity level similar to that of matched control subjects, considerable localized, bilateral multifidus atrophy is present. Such impaired size of the multifidus will likely reduce its capacity to control intersegmental motion, thus increasing the susceptibility to further injury. Unlike acute unilateral low back pain (LBP), muscle size is reduced bilaterally in persons with chronic unilateral LBP. (Source: Archives of Physical Medicine and Rehabilitation)

Short-Term Effect of Superficial Heat Treatment on Paraspinal Muscle Activity, Stature Recovery, and Psychological Factors in Patients With Chronic Low Back Pain

Archives of Physical Medicine and Rehabilitation — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: Use of the heat wrap was associated with a decrease in muscle activity and a short-term improvement in certain aspects of well-being for the CLBP patients. The results confirm the link between the biomechanical and psychological outcome measures. (Source: Archives of Physical Medicine and Rehabilitation)

A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers

International Wound Journal — Wed, 01 Feb 2012 05:00:00 +0100

In conclusion, we found that patients treated with ultrasound therapy and compression therapy show clinical improvement over the course of 4 weeks and had a decrease in inflammatory cytokines, bacterial counts and pain. (Source: International Wound Journal)

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The Economic Cost of Chronic Noncancer Pain in Ireland: Results From the PRIME Study, Part 2

The Journal of Pain — Wed, 01 Feb 2012 05:00:00 +0100

Abstract: To assess the economic cost of chronic pain in Ireland, information was gathered from 140 people with chronic pain. Direct and indirect costs attributable to chronic pain and medical conditions of which chronic pain was a feature were recorded retrospectively for 12 months. Mean cost per chronic pain patient was estimated at €5,665 per year across all grades of pain, with mean costs increasing according to the severity of pain. A small proportion of patients account for the bulk of costs—the top 5% most expensive patients accounted for 26.4% of costs, with a mean cost per patient of €29,936, and the 10% most expensive patients were responsible for 42.8% of all costs. Total cost for individuals aged 20 and above was estimated at €5.34 billion per year, or 2.86% of Irish GD...

Prevalence And Correlates Of Alcohol Use Disorders In The Singapore Mental Health Survey

Addiction — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: The prevalence of alcohol use disorders is relatively low in the Singapore adult population. Comorbidity with mental and physical disorders is significant emphasizing the need to screen persons with alcohol use disorders for these comorbidities. (Source: Addiction)

Chronic Pelvic Pain: Is It Time for an Algorithmic Approach?

Pain Practice — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Pain Practice)

Chronic Female Pelvic Pain—Part 2: Differential Diagnosis and Management

Pain Practice — Wed, 01 Feb 2012 05:00:00 +0100

Abstract: Pelvic pain is a common condition. Treatment interventions have traditionally targeted biomedical conditions with variable success. Utilizing a systematic approach to examination of the pelvic girdle and related organ systems contained within the pelvis will aid the clinician in identifying the painful structure(s) as well as the associated impairments limiting functional recovery. From this, a complete management program can be instituted. The following description of gynecologic, urologic, gastrointestinal, musculoskeletal, and neurologic conditions that can cause or are associated with chronic pelvic pain leads to conservative management proposals based on the available evidence. Finally, nonoperative interventional strategies are described, which target the pain system fro...

Pain and bleeding are the main determinants of unscheduled contacts after outpatient tonsillectomy.

Pain Physician — Wed, 01 Feb 2012 05:00:00 +0100

CONCLUSION: Outpatient tonsillectomy seems safe in Denmark. A minimum postoperative observation period of four hours will reduce the need for postoperative contacts. Because of the potentially life-threatening risk related to tonsillectomy, careful patient selection is mandatory and continuous monitoring of the quality of the procedure is essential. FUNDING: not relevant. TRIAL REGISTRATION: not relevant. PMID: 22293052 [PubMed - in process] (Source: Pain Physician)

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Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain.

Acupuncture in Medicine — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Kopsky DJ, Hesselink JM Abstract Central neuropathic pain is a common debilitating symptom in patients with multiple sclerosis. Side effects of analgesics often limit reaching therapeutic dosages. In this case report, a 61-year-old woman with chronic central neuropathic pain due to multiple sclerosis is described. Acupuncture could only partly and temporarily reduce the pain. However, after adding the natural compound palmitoylethanolamide, a glial modulator and peroxisome proliferator-activated receptor-α agonist, pain reduction was more pronounced and the interval between acupuncture sessions could be increased. A multimodal stepped care approach is demonstrated, with acupuncture and palmitoylethanolamide both influencing non-neuronal cells, such as activated glial cell...

Postoperative Headache Following Acoustic Neuroma Resection: Occipital Nerve Injuries Are Associated With a Treatable Occipital Neuralgia.

Headache — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion.- In contradistinction to previous reports, we have identified a subset of patients in whom the syndrome of postoperative headache appears directly related to the presence of occipital nerve injuries. In patients with postoperative headache meeting diagnostic criteria for occipital neuralgia, occipital nerve excision appears to provide relief of the headache syndrome and meaningful improvement in quality of life. Further studies are needed to confirm these results and to determine whether occipital nerve injury may present as headache types other than occipital neuralgia. These findings suggest that patients presenting with chronic postoperative headache should be screened for the presence of surgically treatable occipital nerve injuries. PMID: 22296035 [PubMed - as supplied...

Healthcare Costs Associated with Osteoarthritis in US Patients

Pain Practice — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion: Newly diagnosed osteoarthritis patients incurred higher annual costs, but lower pain‐related prescription drug costs in the year following diagnosis than patients with existing osteoarthritis. (Source: Pain Practice)

Chronic Pain - A New Understanding

Disabled World — Tue, 31 Jan 2012 20:03:59 +0100

Scripps Research scientists provide new understanding of chronic pain - Findings suggest new target for drug development. (Source: Disabled World)

Living With Rheumatoid Arthritis

MedicineNet Chronic Pain General — Tue, 31 Jan 2012 07:00:00 +0100

Title: Living With Rheumatoid ArthritisCategory: Doctor's ViewsCreated: 8/9/2006Last Editorial Review: 1/31/2012 (Source: MedicineNet Chronic Pain General)

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Does Obesity Cause Pain?

MedicineNet Chronic Pain General — Tue, 31 Jan 2012 07:00:00 +0100

Title: Does Obesity Cause Pain?Category: Health NewsCreated: 1/31/2012 11:00:00 AMLast Editorial Review: 1/31/2012 (Source: MedicineNet Chronic Pain General)

Neuromodulators for pain management in rheumatoid arthritis

NeLM - Drug Class Focused Reviews — Tue, 31 Jan 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Class Focused Reviews Background Pain management is a high priority for patients with rheumatoid arthritis (RA). Despite deficiencies in research data, neuromodulators have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. Objectives The aim of this review was to determine the efficacy and safety of neuromodulators in pain management in patients with RA. Neuromodulators included in this review were anticonvulsants (gabapentin, pregabalin, phenytoin, sodium valproate, lamotrigine, carbamazepine, levetiracetam, oxcarbazepine, tiagabine and topiramate), ketamine, bupropion, methylphenidate, nefopam, capsaicin and the cannabinoids. Search ...

Muscle relaxants for pain management in rheumatoid arthritis

NeLM - Drug Class Focused Reviews — Tue, 31 Jan 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Class Focused Reviews Background Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol and orphenadrine (Muscol)) and drugs that prevent increased muscle tone (baclofen and dantrolene). Despite a paucity of evidence supporting their use, antispasmodic and antispasticity muscle relaxants have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. Objectives The aim of this review was to determin...

Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life

BMC Gastroenterology — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions Main determinants of HRQL were severity of liver disease, age, gender, participating center and response to treatment. Our results do not exclude a more profound negative impact of individualized treatment compared to standard, possibly caused by higher doses and extended treatment duration in the individualized group. Antiviral therapy might have a more intense and more prolonged negative impact on females. (Source: BMC Gastroenterology)

Psychosocial interventions for patients with chronic disease

BioPsychoSocial Medicine — Tue, 31 Jan 2012 05:00:00 +0100

Treatment of patients with chronic diseases will be one of the main challenges of medicine in the future. This paper presents an overview of different origins, mechanism, and symptoms necessary for understanding new and different interventions that include a psychosomatic view.In a psychosomatic therapeutic intervention there are very different targets, such as psychological symptoms, personality traits, attitudes toward disease and life, risk behaviour, and social isolation and as biological targets the change of autonomic imbalance and of the effects of the psycho-endocrinological or psycho-immunological stress responses. And there are also different psychosomatic measures that influence the individual biological, psychological and sociological targets. There is a need to give different ...

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Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia

Arthritis and Rheumatism — Tue, 31 Jan 2012 05:00:00 +0100

CONCLUSIONS:Our findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that tracks intra‐subject with changes in spontaneous chronic pain in FM. We propose that intrinsic connectivity measures could potentially be used either in research or clinical settings as a complementary, more objective outcome. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)

EFFECTS OF METHYLNATREXONE IN PATIENTS WITH NARCOTIC BOWEL SYNDROME: A Pilot Observational Study

Internal Medicine Journal — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions: Methylnatrexone has a positive impact on symptoms in women with NBS, although treatment does induce transient pain following its administration. Larger studies are required to examine its efficacy and longer term safety in this patient group. (Source: Internal Medicine Journal)

Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.

Natural Product Research — Tue, 31 Jan 2012 05:00:00 +0100

This study evaluated the anti-nociceptive and anti-inflammatory effects of triterpenoid-enriched extract of T. dioica root (CETD) in rodents at the doses of 50 and 100 mg kg(-1) body weight po. Anti-nociceptive activity was evaluated by acetic acid-induced writhing and tail flick methods in Swiss albino mice. CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats. In writhing test, CETD dose dependently and significantly inhibited writhes; in tail flick test, CETD demonstrated significant increase in reaction time (after 60 and 120 min). In all the anti-inflammatory models, CETD exhibited promising anti-inflammatory activity in a dose...

L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats

Molecular Pain — Tue, 31 Jan 2012 05:00:00 +0100

Conclusions: These data suggest that the L type Ca2+ channels/NFAT/TRPM8 pathway is a downstream mediator for oxaliplatin-induced cold hyperalgesia, and that Ca2+ channel blockers have prophylactic potential for acute neuropathy. (Source: Molecular Pain)

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

Physiological Reviews — Tue, 31 Jan 2012 05:00:00 +0100

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not only reduces the fidelity of normal sensory processing but also provokes symptoms very much reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn sensory circuits. Particular emphasis is placed on the rol...

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The "AMID" Hernia and Skin Stapler for Lichtenstein Hernia Repair: A Pilot Study.

Surgical Innovation — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion. The Lichtenstein hernia repair using the AMID Stapler is simple and safe and resulted in lower acute postoperative pain and lower analgesic consumption as compared with the sutured Lichtenstein hernia repair. A multicenter clinical trial with a large sample size is needed to more accurately study pain reduction. PMID: 22298754 [PubMed - as supplied by publisher] (Source: Surgical Innovation)

Reduced insular γ‐aminobutyric acid in fibromyalgia

Arthritis and Rheumatism — Mon, 30 Jan 2012 13:25:29 +0100

ConclusionDiminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes. (Source: Arthritis and Rheumatism)

Health Tip: How to Protect Toddlers From Burns

MedicineNet Chronic Pain General — Mon, 30 Jan 2012 07:00:00 +0100

Title: Health Tip: How to Protect Toddlers From BurnsCategory: Health NewsCreated: 1/30/2012 8:05:00 AMLast Editorial Review: 1/30/2012 (Source: MedicineNet Chronic Pain General)

Those Extra Pounds Could Harm Your Back

MedicineNet Chronic Pain General — Mon, 30 Jan 2012 07:00:00 +0100

Title: Those Extra Pounds Could Harm Your BackCategory: Health NewsCreated: 1/30/2012 10:05:00 AMLast Editorial Review: 1/30/2012 (Source: MedicineNet Chronic Pain General)

Nonpharmacological Approaches to the Management of Chronic Pain in Community‐Dwelling Older Adults: A Review of Empirical Evidence

Journal of the American Geriatrics Society — Mon, 30 Jan 2012 05:00:00 +0100

The objective of this literature review is to gain insight into the efficacy of nonpharmacological interventions in chronic pain management in community‐dwelling older adults. An extensive search of pertinent databases was performed to identify reports of studies of nonpharmacological (physical and psychosocial) pain interventions. The review identifies intervention studies that used randomized controlled trials (RCTs) and summarizes existing evidence of effectiveness of nonpharmacological interventions. A literature search yielded 28 RCT intervention studies (18 for physical interventions and 10 for psychosocial interventions) that met inclusion criteria and are included in this review. Twenty‐one studies (75%) identified in this review demonstrated statistically significant differenc...

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Pediatric Headache: A Clinical Review

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

In this review we describe the epidemiology, classification, and approach to the diagnosis and treatment of episodic and chronic migraine in children. We review both traditional and alternative medications, and offer a glimpse into the future of pediatric headache. (Source: Headache: The Journal of Head and Face Pain)

Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome in a Chronic Hemodialysis Patient

Advances in Pharmacological Sciences — Sun, 29 Jan 2012 18:41:46 +0100

A 75-year-old male who was undergoing chronic hemodialysis developed abrupt-onset pitting edema and pain in the dorsum of both hands and feet. Biochemical analysis disclosed increased C-reactive protein, and negative rheumatoid factor and antinuclear antibody. Radiological examination showed no bony erosion. Computed tomography and gallium scintigraphy revealed no active infection or neoplasms. The clinical diagnosis was remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. The pitting edema and inflammatory response quickly subsided after low-dose prednisolone therapy. This case demonstrates that RS3PE syndrome could be a differential diagnosis in elderly patients undergoing dialysis who develop pitting edema and joint pain. (Source: Advances in Pharmacological...

Depending on a Woman's Age, Hysterectomy May Be the Best Option for Resolving Chronic Pelvic Pain and Heavy Bleeding

MedlinePlus Health News — Sun, 29 Jan 2012 13:20:51 +0100

Source: Agency for Healthcare Research and Quality Related MedlinePlus Page: Hysterectomy (Source: MedlinePlus Health News)

2. The blink reflex: Long known, but still fascinating

Clinical Neurophysiology — Sat, 28 Jan 2012 16:42:16 +0100

The blink reflex is routinely used in clinical neurophysiology to characterize the functional integrity of the trigemino-facial reflex pathway covering supraorbital nerve, pons, medulla oblongata, and facial nerve. Recent findings of unconditioned blink reflex alterations, as well as changes in blink reflex modulation by subthreshold prepulse stimuli or suprathreshold double pulse stimulation, in patients with spinal cord injury or chronic pain syndromes, e.g. fibromyalgia, suggest plastic changes at the brainstem level in these conditions. The blink reflex and its modulation also serve to document acute pharmacological effects, e.g. following intrathecal bolus application of the GABA-ergic drug baclofen, thus concurring with an antispastic action of baclofen at the brainstem level. Finall...

Attitudes toward euthanasia among doctors in a tertiary care hospital in South India: A cross sectional study

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Conclusions: A majority of the doctors in this study supported euthanasia for the relief of unbearable pain and suffering. Religion and speciality appear to be significant in determining attitudes toward euthanasia. (Source: Indian Journal of Palliative Care)

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Opioid-prescribing practices in chronic cancer pain in a tertiary care pain clinic

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Conclusion: This study shows that the under treatment of pain and under dosing of opioids coupled with improper side effect management are major issues. (Source: Indian Journal of Palliative Care)

Attitudes and beliefs about chronic pain among nurses- biomedical or behavioral? A cross-sectional survey

Indian Journal of Palliative Care — Sat, 28 Jan 2012 05:00:00 +0100

Conclusions: Nurses had a greater orientation toward the biomedical dimension of chronic pain than the behavioral dimension. This difference was more pronounced in female nurses and those nurses who reported "very good" general health had higher behavioral dimension scores than those who had "good" general health. The study findings have important curricular implications for nurses and practical implications in palliative care. (Source: Indian Journal of Palliative Care)

Quality of life and surgical outcomes following laparoscopic surgery for refractory gastroesophageal reflux disease in a regional hospital.

Canadian Journal of Surgery — Fri, 27 Jan 2012 16:01:36 +0100

Conclusion: Excellent surgical outcomes in LAR surgery can be obtained with careful patient selection at a nonacademic regional hospital. Although GERD-HRQL improved in all patients, patients with CPS showed no improvement in general health QOL scores after LAR surgery. Careful patient counselling should be employed when offering LAR surgery to patients with CPS. PMID: 22269301 [PubMed - in process] (Source: Canadian Journal of Surgery)

A giant true aneurysm of the celiac trunk

Journal of Vascular Surgery — Fri, 27 Jan 2012 11:25:15 +0100

A 80-year-old man was admitted to our department because of an arterial dilatation into the abdomen recorded during a routine ultrasound scan. His medical history was notable for smoking, chronic obstructive pulmonary disease, hypertension, hypercholesterolemia, and atrial fibrillation in anticoagulant therapy. The patient never underwent abdominal surgery and he was asymptomatic for abdominal pain. (Source: Journal of Vascular Surgery)

Long‐term outcomes and costs of an integrated rehabilitation program for chronic knee pain: A pragmatic, cluster randomized, controlled trial

Arthritis Care and Research — Fri, 27 Jan 2012 10:29:25 +0100

ConclusionClinical and cost benefits of ESCAPE‐knee pain were still evident 30 months after completing the program. ESCAPE‐knee pain is a more effective and efficient model of care that could substantially improve the health, well‐being, and independence of many people, while reducing health care costs. (Source: Arthritis Care and Research)

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Study Finds No Link Between HPV Vaccine and Autoimmune Disorders

MedicineNet Chronic Pain General — Fri, 27 Jan 2012 07:00:00 +0100

Title: Study Finds No Link Between HPV Vaccine and Autoimmune DisordersCategory: Health NewsCreated: 1/26/2012 2:05:00 PMLast Editorial Review: 1/27/2012 (Source: MedicineNet Chronic Pain General)

Propagation of Spinal Nociceptive Activity in the Spatial and Temporal Domains

The Neuroscientist — Fri, 27 Jan 2012 05:00:00 +0100

Nociceptive stimuli are transmitted through thinly myelinated or unmyelinated primary afferent fibers called nociceptors, which terminate mainly in the superficial dorsal horn of the spinal cord. While most nociceptive fibers terminate in the spinal segment of the entrance, (collateral) fibers may ascend and descend several segments upon their entry into the spinal cord, which is reflected in the receptive fields of central nociceptive neurons. In chronic pain states like inflammatory or neuropathic pain, the area of nociceptive activity may expand even further in rostrocaudal and mediolateral directions. Also, within minutes (inflammatory pain) or days (neuropathic pain), an increased sensitivity of peripheral and central nociceptive neurons will develop, which is referred to as sensitiza...

Depressive Symptoms, Chronic Pain, and Falls in Older Community‐Dwelling Adults: The MOBILIZE Boston Study

Journal of the American Geriatrics Society — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionDepressive symptoms are associated with fall risk in older adults and are mediated in part by chronic pain. Research is needed to determine effective strategies for reducing fall risk and related injuries in older people with pain and depressive symptoms. (Source: Journal of the American Geriatrics Society)

Clinical Presentation and Management of Histoplasmosis in Older Adults

Journal of the American Geriatrics Society — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionAlthough most studied characteristics of histoplasmosis were similar, notable age‐related differences were present. Chronic cavitary disease and asymptomatic histoplasmosis were more common with older age. In acute histoplasmosis, the lack of chest pain and hilar lymphadenopathy may hinder diagnosis in older adults. (Source: Journal of the American Geriatrics Society)

Exercise may boost mood for some chronically ill

Reuters: Health — Thu, 26 Jan 2012 18:37:54 +0100

NEW YORK (Reuters Health) - Working out regularly may brighten the mood of people with chronic health problems like cancer, heart disease and back pain, according to the first sweeping look at previous research. (Source: Reuters: Health)

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Muscle relaxants for pain management in rheumatoid arthritis.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: Based upon the currently available evidence in patients with RA, benzodiazepines (diazepam and triazolam) do not appear to be beneficial in improving pain over 24 hours or one week. The non-benzodiazepine agent zopiclone also did not significantly reduce pain over two weeks. However, even short term muscle relaxant use (24 hours to 2 weeks) is associated with significant adverse events, predominantly drowsiness and dizziness. PMID: 22258993 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Neuromodulators for pain management in rheumatoid arthritis.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: There is currently weak evidence that oral nefopam, topical capsaicin and oromucosal cannabis are all superior to placebo in reducing pain in patients with RA. However, each agent is associated with a significant side effect profile. The confidence in our estimates is not strong given the difficulties with blinding, the small numbers of participants evaluated and the lack of adverse event data. In some patients, however, even a small degree of pain relief may be considered worthwhile. Until further research is available, given the relatively mild nature of the adverse events, capsaicin could be considered as an add-on therapy for patients with persistent local pain and inadequate response or intolerance to other treatments. Oral nefopam and oromucosal cannabis have more signif...

Endoscopic or surgical intervention for painful obstructive chronic pancreatitis.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: For patients with obstructive chronic pancreatitis and dilated pancreatic duct, this review showed that surgery is superior to endoscopy in terms of pain control. Morbidity and mortality seemed not to differ between the two intervention modalities, but the small trials identified do not provide sufficient power to detect the small differences expected in this outcome.Regarding the comparison of surgical intervention versus conservative treatment, this review has shown that surgical intervention in an early stage of chronic pancreatitis seems to be a promising approach in terms of pain control and pancreatic function. Confirmation of these results is needed in other trials due to the methodological limitations and limited number of patients of the present evidence. PMID: 22...

Pentoxifylline for endometriosis.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: This review has been updated in 2011. The results of the original review published in 2009 remain unchanged. There is still not enough evidence to support the use of pentoxifylline in the management of premenopausal women with endometriosis in terms of subfertility and relief of pain outcomes. PMID: 22258970 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Health Tip: Caring for Minor Burns

MedicineNet Chronic Pain General — Thu, 26 Jan 2012 07:00:00 +0100

Title: Health Tip: Caring for Minor BurnsCategory: Health NewsCreated: 1/26/2012 8:05:00 AMLast Editorial Review: 1/26/2012 (Source: MedicineNet Chronic Pain General)

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Too Many Rheumatoid Arthritis Patients Inactive, Study Finds

MedicineNet Chronic Pain General — Thu, 26 Jan 2012 07:00:00 +0100

Title: Too Many Rheumatoid Arthritis Patients Inactive, Study FindsCategory: Health NewsCreated: 1/26/2012 10:05:00 AMLast Editorial Review: 1/26/2012 (Source: MedicineNet Chronic Pain General)

Patient Story: Rheumatoid Arthritis and Pregnancy

MedicineNet Chronic Pain General — Thu, 26 Jan 2012 07:00:00 +0100

Title: Patient Story: Rheumatoid Arthritis and PregnancyCategory: Doctor's ViewsCreated: 1/26/2012 12:30:00 PMLast Editorial Review: 1/26/2012 (Source: MedicineNet Chronic Pain General)

Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review

Surgical Endoscopy — Thu, 26 Jan 2012 06:55:34 +0100

Conclusions Clinical evidence published to date supports the use of Tisseel/Tissucol as an option for mesh fixation in open and laparoscopic/endoscopic repair of inguinal and incisional hernias. Guidelines of the International Endohernia Society recommend fibrin sealant mesh fixation, especially in inguinal hernia repair. Nonfixation is reserved for selected cases. Content Type Journal ArticleCategory ReviewPages 1-10DOI 10.1007/s00464-012-2156-0Authors René H. Fortelny, Department of General, Visceral and Oncological Surgery, Wilhelminenspital, Vienna, AustriaAlexander H. Petter-Puchner, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, AustriaKarl S. Glaser, Department of General, Visceral and Oncological Surgery, Wilhelminenspital, V...

Splenic infarction in a child revealing chronic myeloid leukemia

European Journal of Pediatrics — Thu, 26 Jan 2012 06:44:12 +0100

Abstract A 7-year-old girl was admitted with a severe abdominal pain. Abdominal ultrasound and CT revealed a large splenic infarction, leading to the diagnosis of chronic myeloid leukemia. Content Type Journal ArticleCategory Images in PediatricsPages 1-2DOI 10.1007/s00431-012-1675-yAuthors David Drummond, Department of Pediatric Hematology and Oncology, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris (APHP), Université Pierre et Marie Curie (Paris 6), 26, avenue Arnold Netter, 75012 Paris, FranceMarion Lenoir, Department of Radiology, Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris (APHP), Université Pierre et Marie Curie (Paris 6), 26, avenue Arnold Netter, 75012 Paris, FranceArnaud Y. Petit, Department of Pediatric Hematology and ...

Radiofrequency Neurolysis in the Management of Inguinal Neuralgia: Preliminary Study [Vascular and Interventional Radiology]

Radiology — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion: RFN with CT guidance is an effective technique in the management of refractory inguinal pain with lasting satisfactory pain reduction; it may be considered as an alternative treatment to surgery. These results should be confirmed in a controlled trial with a larger series of patients. © RSNA, 2011 (Source: Radiology)

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Exercise may boost mood for some chronically ill

Reuters: Health — Wed, 25 Jan 2012 22:31:17 +0100

Exercise May Boost Mood for Some Chronically Ill

MedlinePlus Health News — Wed, 25 Jan 2012 22:30:54 +0100

Working out regularly may brighten the mood of people with chronic health problems like cancer, heart disease and back pain, according to the first sweeping look at previous research.Source: Reuters Health Related MedlinePlus Pages: Coping with Chronic Illness, Exercise and Physical Fitness (Source: MedlinePlus Health News)

Pearls: Managing Chronic Pain in the EDPearls: Managing Chronic Pain in the ED

Medscape Today Headlines — Wed, 25 Jan 2012 14:59:41 +0100

What's the best way to manage the patient presenting to the ED with acute pain? Medscape Emergency Medicine (Source: Medscape Today Headlines)

A 72-Year-Old Woman With Chronic Pain and TearingA 72-Year-Old Woman With Chronic Pain and Tearing

Medscape Today Headlines — Wed, 25 Jan 2012 14:57:07 +0100

A 72-year-old woman presents with chronic pain and tearing in one eye. What is your diagnosis? Medscape Ophthalmology (Source: Medscape Today Headlines)

[Repair of chronic ruptures of the gluteus medius muscle using a nonresorbable patch.]

Operative Orthopadie und Traumatologie — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Fink B Abstract OBJECTIVE: Repair of a chronic rupture with a defect of the gluteus medius muscle with or without a total hip replacement. Improvement of gait and limping by functional stabilization of the pelvis. Reduction of pain in the region of the greater trochanter. INDICATIONS: Chronic rupture with a defect of the gluteus medius. CONTRAINDICATIONS: Complete bony defect and absence of the greater trochanter and hip infection. OPERATIVE TECHNIQUE: Lateral positioning of the patient. Longitudinal incision of 12-15 cm over the greater trochanter. Preparation to the fascia and longitudinal incision slightly dorsal to the greater trochanter. Preparation and mobilizatio...

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Elite Swimmers With Unilateral Shoulder Pain Demonstrate Altered Pattern of Cervical Muscles Activation During a Functional Upper Limb Task.

Physical Therapy — Wed, 25 Jan 2012 05:00:00 +0100

CONCLUSIONS: The elite swimmers with shoulder pain demonstrated greater activation of the SCL muscles during a functional task and a lower ability to relax the SCL muscles after completion of the task than elite swimmers without shoulder pain. The present findings suggest altered pattern of cervical muscle activation on elite swimmers with shoulder pain during performance of a functional task. J Orthop Sports Phys Ther, Epub 25 January 2012. doi:10.2519/jospt.2012.3875. PMID: 22282107 [PubMed - as supplied by publisher] (Source: Physical Therapy)

Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines.

Journal of Medical Toxicology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Rosenbaum CD, Carreiro SP, Babu KM Abstract Despite their widespread Internet availability and use, many of the new drugs of abuse remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or Spice, are a group of herbal blends that contain a mixture of plant matter in addition to chemical grade synthetic cannabinoids. The synthetic cathinones, commonly called "bath salts," have resulted in nationwide emergency department visits for severe agitation, sympathomimetic toxicity, and death. Kratom, a plant product derived from Mitragyna speciosa Korth, has opioid-like effects, and has been used for the treatment of chronic pain and amelioration of opioid-withdrawal symptoms. Salvia divinorum is a hallucinogen with unique pharmacology that has thera...

Role of Medical Therapy in the Management of Nasal Polyps

Current Allergy and Asthma Reports — Tue, 24 Jan 2012 18:14:41 +0100

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the nasal and paranasal sinus mucosa that, despite differing hypotheses regarding its cause, remains poorly understood. Major symptoms are nasal congestion or blockage, loss of smell, rhinorrhea, postnasal drip, and facial pain or pressure. Among the objectives of CRSwNP management are to eradicate nasal polyps from nasal and sinusal cavities, eliminate symptoms, and prevent recurrences. Corticosteroids are the mainstay of treatment and are the most effective drugs for treating CRSwNP. Other potential treatments are nasal saline irrigation and antihistamines (in allergic conditions). Endoscopic sinus surgery is recommended when medical treatment fails. After surgery, medical tre...

Well: In Rating Pain, Women Are the More Sensitive Sex

NYT — Tue, 24 Jan 2012 17:54:51 +0100

A Stanford study found that women reported higher levels than men suffering the same chronic ailments. (Source: NYT)

The role of sodium channels in chronic pain

Muscle and Nerve — Tue, 24 Jan 2012 14:12:22 +0100

AbstractHere we review recent research into the mechanisms of chronic pain that has focused on neuronal sodium channels, a target of classic analgesic agents. We first discuss evidence that specific sodium channel isoforms are essential for the detection and conduction of normal acutely painful stimuli from nociceptors. We then review findings that show changes in sodium channel expression and localization in chronic inflammation and nerve injury in animal and human tissues. We conclude by discussing the role that myelination plays in organizing and maintaining sodium channel clusters at nodes of Ranvier in normal development and how inflammatory processes or nerve injury alter the characteristics of such clusters. Based on these findings, we suggest that chronic pain may in part result fr...

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The Patient-Provider Relationship in Chronic Pain

Current Pain and Headache Reports — Tue, 24 Jan 2012 12:27:19 +0100

Abstract The relationship between patient and provider has long been the subject of study within the psychotherapy literature, with the available data suggesting a modest, but reliable, association between the strength of this relationship and treatment outcome. Conversely, there has been little work focused on the patient–provider relationship in chronic pain settings despite the complexities and difficulties that are often involved in this area. This review provides a brief, broad overview of the literature on the patient–provider relationship and identifies key aspects that are specifically relevant to chronic pain settings. In addition to reviewing the literature in this area, a series of recommendations for future clinical and academic work are offered. Conte...

Spine stabilisation exercises in the treatment of chronic low back pain: a good clinical outcome is not associated with improved abdominal muscle function

European Spine Journal — Tue, 24 Jan 2012 07:32:44 +0100

Conclusion Neither baseline lateral abdominal muscle function nor its improvement after a programme of stabilisation exercises was a statistical predictor of a good clinical outcome. It is hence difficult to attribute the therapeutic result to any specific effects of the exercises on these trunk muscles. The association between changes in catastrophising and outcome serves to encourage further investigation on larger groups of patients to clarify whether stabilisation exercises have some sort of “central” effect, unrelated to abdominal muscle function per se. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00586-012-2155-9Authors A. F. Mannion, Spine Center Division, Department of Research and Development, Schulthess Klinik, Lenggha...

Hip Fracture Patients Often Have Other Health Problems

MedicineNet Chronic Pain General — Tue, 24 Jan 2012 07:00:00 +0100

Title: Hip Fracture Patients Often Have Other Health ProblemsCategory: Health NewsCreated: 1/23/2012 4:06:00 PMLast Editorial Review: 1/24/2012 (Source: MedicineNet Chronic Pain General)

Health Tip: Exercise for Healthier Bones

MedicineNet Chronic Pain General — Tue, 24 Jan 2012 07:00:00 +0100

Title: Health Tip: Exercise for Healthier BonesCategory: Health NewsCreated: 1/24/2012 8:05:00 AMLast Editorial Review: 1/24/2012 (Source: MedicineNet Chronic Pain General)

Enriched Milk May Ease Gout

MedicineNet Chronic Pain General — Tue, 24 Jan 2012 07:00:00 +0100

Title: Enriched Milk May Ease GoutCategory: Health NewsCreated: 1/24/2012 11:00:00 AMLast Editorial Review: 1/24/2012 (Source: MedicineNet Chronic Pain General)

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Women May Feel More Pain Than Men

MedicineNet Chronic Pain General — Tue, 24 Jan 2012 07:00:00 +0100

Title: Women May Feel More Pain Than MenCategory: Health NewsCreated: 1/24/2012 11:00:00 AMLast Editorial Review: 1/24/2012 (Source: MedicineNet Chronic Pain General)

Pelvic pain in urogynecology. Part II: treatment options in patients with lower urinary tract symptoms

International Urogynecology Journal — Tue, 24 Jan 2012 06:45:56 +0100

Abstract Therapeutic options for chronic pelvic pain in women offer only a limited symptom relief. Especially in the patient with lower urinary tract symptoms (LUTS), where overlap of pain, storage and voiding symptoms is common, data on the efficacy of treatment of pain are limited. We conducted a literature review to detect articles which pertained to female patients with LUTS and pelvic pain and we included articles which evaluated the efficacy of the treatment of pelvic pain. Forty-one articles were detected, which included nerve stimulation (sacral and pudendal), intravesical instillations and injections, oral pharmacological treatments, periurethral injections as well as physical and manual therapy as treatment options. Only five controlled trials were found, which d...

Understanding Chronic Pain

Medical Headlines From Ivanhoe.com — Tue, 24 Jan 2012 05:00:00 +0100

(Ivanhoe Newswire) -- Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. (Source: Medical Headlines From Ivanhoe.com)

Identifying factors relevant in the assessment of return-to-work efforts in employees on long-term sickness absence due to chronic low back pain: a focus group study

BMC Public Health - Latest articles — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: This focus group study shows that 19 factors may be relevant to RTW-ES in sick-listed employees with CLBP. Providing these results to professionals assessing RTW-ES might contribute to a more transparent and systematic approach. Considering the importance of the quality of the RTW process, optimizing the RTW-ES assessment is essential. (Source: BMC Public Health - Latest articles)

Common and Less Common Peripheral Nerve Disorders Associated with Diabetes.

Current Diabetes Reviews — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Knopp M, Rajabally YA Abstract Diabetes can be associated with a number of peripheral nerve disorders. The commonest is slowly-progressive axonal distal symmetrical sensori-motor neuropathy. Sensory loss and positive sensory symptoms are its main manifestations. Lumbosacral radiculoplexus neuropathy (LSRPN) is a distinct entity, accompanied by severe lumbar, hip, leg pain and weight loss, with subsequent weakness. Although typically unilateral, bilaterality is described, with spontaneous recovery usual over several months. The upper limb counterpart, cervical radiculoplexus neuropathy is rare. Acute painful neuropathies, including "diabetic neuropathic cachexia", are infrequent. Accompanying weight loss is usual and burning pains in the extremities are severe. Insulin-trig...

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Well: In Rating Pain, Women Are the More Sensitive Sex

NYT Health — Mon, 23 Jan 2012 22:18:55 +0100

A Stanford study found that women reported higher levels than men suffering the same chronic ailments. (Source: NYT Health)

Neck pain: manipulation of your neck and upper back leads to quicker recovery.

Physical Therapy — Mon, 23 Jan 2012 15:30:06 +0100

Authors: Abstract Neck pain is very common and fortunately resolves quickly in most individuals. However, in certain cases neck pain can last longer and result in chronic pain, limited neck motion, and disability. In fact, chronic neck pain is the second leading cause of workers' compensation claims in the United States. Treatments that can quickly reduce pain, increase motion, and improve the ability of the muscles to protect the neck may help decrease long-term disability associated with neck pain. A variety of manual therapy treatments are currently used to manage neck pain. These treatments include mobilization, which slowly and repeatedly moves the neck joints and muscles, and manipulation, which delivers a single, small, quick movement to the joints and muscles. A research r...

Research Scientists Provide New Understanding Of Chronic Pain

Health News from Medical News Today — Mon, 23 Jan 2012 09:00:00 +0100

Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. Precisely how this pain persists has been a mystery, and current treatments are largely ineffective. But a team led by scientists from The Scripps Research Institute, using a new approach known as metabolomics, has now discovered a major clue: dimethylsphingosine (DMS), a small-molecule byproduct of cellular membranes in the nervous system... (Source: Health News from Medical News Today)

Avoid Getting Scorched by 'Hot Yoga'

MedicineNet Chronic Pain General — Mon, 23 Jan 2012 07:00:00 +0100

Title: Avoid Getting Scorched by 'Hot Yoga'Category: Health NewsCreated: 1/22/2012 10:05:00 AMLast Editorial Review: 1/23/2012 (Source: MedicineNet Chronic Pain General)

Health Highlights: Jan. 22, 2012

MedicineNet Chronic Pain General — Mon, 23 Jan 2012 07:00:00 +0100

Title: Health Highlights: Jan. 22, 2012Category: Health NewsCreated: 1/22/2012 8:05:00 PMLast Editorial Review: 1/23/2012 (Source: MedicineNet Chronic Pain General)

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Severe Brain Injury When Young May Have Long-Term Effects

MedicineNet Chronic Pain General — Mon, 23 Jan 2012 07:00:00 +0100

Title: Severe Brain Injury When Young May Have Long-Term EffectsCategory: Health NewsCreated: 1/23/2012 10:05:00 AMLast Editorial Review: 1/23/2012 (Source: MedicineNet Chronic Pain General)

Fighting Neuropathic Pain

Chemical and Engineering News — Mon, 23 Jan 2012 06:00:39 +0100

Metabolomics: Researchers discover a metabolite associated with chronic pain from tissue injury (Source: Chemical and Engineering News)

OnabotulinumtoxinA for Chronic Migraine

Headache: The Journal of Head and Face Pain — Mon, 23 Jan 2012 05:00:00 +0100

(Source: Headache: The Journal of Head and Face Pain)

Nursing leadership in a chronic pain management group approach

Journal of Nursing Management — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions The results show how important it is to have firm overall leadership and trained group leaders with a common purpose, interdependent roles and complementary skills, who are thus well prepared to prevent or deal with challenging group processes.Implications for nursing management The leaders of both levels, which are highly interrelated, should have a current theoretical understanding of pain theory, group leadership skills and a cognitive behavioural approach. (Source: Journal of Nursing Management)

Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Molecular Pain — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: These results highlight the importance of signaling to translation control in peripheral sensitization of nociceptors and provide further evidence for activation of AMPK as a novel treatment avenue for acute and chronic pain states. (Source: Molecular Pain)

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Anti-Inflammatory Activity of the Aqueous Extract of Ficus Deltoidea

Biological Research For Nursing — Mon, 23 Jan 2012 05:00:00 +0100

In conclusion, the leaf of F. deltoidea possesses anti-inflammatory activity against acute and chronic inflammatory responses and against pain-associated inflammatory response. These findings justify the traditional uses of F. deltoidea leaves for treatment of inflammatory-mediated ailments. (Source: Biological Research For Nursing)

"Governed by the pain": narratives of fibromyalgia.

Disability and Rehabilitation — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: The narrative is characterized by a lack of movement and resolution, with participants engaged in an enduring struggle against the challenges of FM. Psychological approaches that facilitate this ongoing adjustment process may prove beneficial in FM treatment and rehabilitation. [Box: see text]. PMID: 22263672 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)

New understanding of chronic pain

ScienceDaily Headlines — Sun, 22 Jan 2012 20:24:24 +0100

Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. Precisely how this pain persists has been a mystery, and current treatments are largely ineffective. But scientists, using a new approach known as metabolomics, have now discovered a major clue: dimethylsphingosine (DMS), a small-molecule byproduct of cellular membranes in the nervous system. In their new study, the scientists found that DMS is produced at abnormally high levels in the spinal cords of rats with neuropathic pain and appears to cause pain when injected. The findings suggest inhibiting this molecule may be a fruitful target for drug development. (Source: ScienceDaily Headlines)

Scripps Research scientists provide new understanding of chronic pain

EurekAlert! - Medicine and Health — Sun, 22 Jan 2012 05:00:00 +0100

(Scripps Research Institute) Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. Precisely how this pain persists has been a mystery, and current treatments are largely ineffective. But a team led by scientists from the Scripps Research Institute, using a new approach known as metabolomics, has now discovered a major clue: dimethylsphingosine, a small-molecule byproduct of cellular membranes in the nervous system. (Source: EurekAlert! - Medicine and Health)

Primate model research for endometriosis.

The Tohoku Journal of Experimental Medicine — Sat, 21 Jan 2012 20:00:02 +0100

Authors: Yamanaka A, Kimura F, Takebayashi A, Kita N, Takahashi K, Murakami T Abstract Endometriosis is defined as the existence of endometrial tissue outside the uterine cavity, and it includes a chronic, inflammatory reaction associated with female infertility and pelvic pain. Endometriosis occurs in 7 to 10% of women. Although it has been studied for more than 50 years, the pathogenesis and development of endometriosis are still poorly understood. There is no curative therapy for endometriosis, which often recurs after surgical or medical treatment. There is a consensus that the adverse current of menstrual blood plays a crucial role in the development of endometriosis. This places a major limitation on research using rodent models of endometriosis, although these are still wide...

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Stress-induced visceral analgesia assessed non-invasively in rats is enhanced by prebiotic diet.

World Journal of Gastroenterology : WJG — Sat, 21 Jan 2012 05:00:00 +0100

CONCLUSION: These data provide the first evidence of psychological stress-related visceral analgesia in rats that was enhanced by chronic intake of ERF prebiotic. PMID: 22294825 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Painful bladder syndrome

Obstetrics, Gynaecology and Reproductive Medicine — Sat, 21 Jan 2012 03:20:54 +0100

Abstract: Painful bladder syndrome is a chronic debilitating condition which is both difficult to diagnose and to treat. Its aetiology and pathogenesis is very poorly understood. It is thought that mast cells and inflammation have a key role in its pathogenesis.A diagnosis is generally made after all other potential causes of pain and lower urinary tract symptoms are excluded. Treatment options are very limited but are generally targeted to providing symptomatic relief. (Source: Obstetrics, Gynaecology and Reproductive Medicine)

The Lonely Screams: Understanding the Complex World of the Lonely

Psych Central — Fri, 20 Jan 2012 20:56:04 +0100

Loneliness is certainly a common human experience; even if you’ve been lucky enough to feel it only briefly, or rarely, you know the misery of it, the actual physical pain of it. Arising from a feeling of having inadequately meaningful social relationships, loneliness can become a chronic condition for some people, and this book collects their voices. The Lonely Screams, by Sean Seepersad, presents a curated collection of essays contributed to Seepersad’s website, Web of Loneliness. The stories are often wrenching and sad, and Seepersad follows each essay with his thoughts about the origin of and solution to the writer’s loneliness. Aside from his clinical and academic interest in the subject, Seepersad has a personal interest; the final chapter is his own essay about his experien...

Major Public Health Campaign Called For By Stanford Dean To Fight Epidemic Of Unnecessary Suffering

Health News from Medical News Today — Fri, 20 Jan 2012 09:00:00 +0100

The amount of needless suffering caused by both acute and chronic pain in the United States is a major, overlooked medical problem that requires improved education at multiple levels, stretching from the implementation of new public health campaigns to better training of primary care physicians in pain management. "The magnitude of pain in the United States is astounding," write the authors of a perspective piece published in the New England Journal of Medicine. The article is co-authored by Philip Pizzo, MD, dean of the Stanford University School of Medicine... (Source: Health News from Medical News Today)

Operant Learning Theory in Pain and Chronic Pain Rehabilitation

Current Pain and Headache Reports — Fri, 20 Jan 2012 07:06:21 +0100

Abstract The application of operant learning theory on chronic pain by Fordyce has had a huge impact on chronic pain research and management. The operant model focuses on pain behaviors as a major component of the pain problem, and postulates that they are subject to environmental contingencies. The role of operant learning in pain behaviors generally has been supported by experimental studies, which are reviewed in the present article. Subsequently, the rationale, goals, and methods of operant behavioral treatment of chronic pain are outlined. Special attention is paid to three therapeutic techniques (graded activity, activity pacing, and time-contingent medication management), which are discussed in detail with regard to their operationalization, effectiveness, and (poss...

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Insomnia Can Be Dangerous, But There's Rest for the Weary

MedicineNet Chronic Pain General — Fri, 20 Jan 2012 07:00:00 +0100

Title: Insomnia Can Be Dangerous, But There's Rest for the WearyCategory: Health NewsCreated: 1/20/2012 11:00:00 AMLast Editorial Review: 1/20/2012 (Source: MedicineNet Chronic Pain General)

5 Surprising Facts About Rheumatoid Arthritis

MedicineNet Chronic Pain General — Fri, 20 Jan 2012 07:00:00 +0100

Title: 5 Surprising Facts About Rheumatoid ArthritisCategory: Doctor's ViewsCreated: 1/20/2012 2:15:00 PMLast Editorial Review: 1/20/2012 (Source: MedicineNet Chronic Pain General)

Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.

Autonomic Neuroscience — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Oliveira LR, de Melo VU, Macedo FN, Barreto AS, Badaue-Passos D, Viana Dos Santos MR, Dias DP, Sluka KA, Desantana JM, Santana-Filho VJ Abstract Fibromyalgia (FM) is characterized by chronic non-inflammatory widespread pain (CWP) and changes in sympathetic function. In attempt to elucidate the pathophysiological mechanisms of FM we used a well-established CWP animal model. We aimed to evaluate changes in cardiac autonomic balance and baroreflex function in response to CWP induction in rats. CWP was induced by two injections of acidic saline (pH 4.0, n=8) five days apart into the left gastrocnemius muscle. Control animals were injected twice with normal saline (pH 7.2, n=6). One day after the second injection of acidic saline or normal saline, the animals had pulse interval...

Targeting soluble epoxide hydrolase for inflammation and pain - An overview of pharmacology and the inhibitors.

Inflammation and Allergy Drug Targets — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Pillarisetti S, Khanna I Abstract Chronic inflammation is an important contributing factor to a variety of human diseases including rheumatoid arthritis, inflammatory bowel disease, psoriasis and atherosclerosis. Epoxidation of arachidonic acid by cytochrome P450 enzymes during inflammation yields epoxyeicosatrienoic acids (EETs). EETs have a variety of biological effects including modulation of inflammation, vascular smooth muscle migration and platelet aggregation. The EETs levels are regulated by soluble epoxide hydrolase (sEH), the major enzyme responsible for their degradation and conversion to inactive dihydroxyeicosatrienoic acids (DHETs); thereby limiting many of the biological actions of EETs. The molecular and pharmacological inhibition of sEH has been studied ex...

Effects of Percutaneous Tibial Nerve Stimulation Therapy on Chronic Pelvic Pain

Gynecologic and Obstetric Investigation — Thu, 19 Jan 2012 23:00:00 +0100

Gynecol Obstet Invest (DOI:10.1159/000328447) (Source: Gynecologic and Obstetric Investigation)

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Cost-effectiveness of a classification-based system for sub-acute and chronic low back pain

European Spine Journal — Thu, 19 Jan 2012 07:01:31 +0100

Conclusion The classification-based treatment approach as used in this study was not cost-effective in comparison with usual physical therapy care in a population of patients with sub-acute and chronic LBP. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s00586-011-2144-4Authors Adri T. Apeldoorn, Department of Epidemiology and Biostatistics and the EMGO+ Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, Amsterdam, 1081 BT The NetherlandsJudith E. Bosmans, Department of Health Sciences and the EMGO+ Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The NetherlandsRaymond W. Ostelo, Department of Epidemiology and Biostatistics and the...

Genes May Give Clues to Severe Form of Lupus

MedicineNet Chronic Pain General — Thu, 19 Jan 2012 07:00:00 +0100

Title: Genes May Give Clues to Severe Form of LupusCategory: Health NewsCreated: 1/18/2012 2:06:00 PMLast Editorial Review: 1/19/2012 (Source: MedicineNet Chronic Pain General)

The Role of Exercise and Types of Exercise in the Rehabilitation of Chronic Pain: Specific or Nonspecific Benefits

Current Pain and Headache Reports — Thu, 19 Jan 2012 06:58:50 +0100

This article summarizes the types of exercise in the rehabilitation of chronic pain patients and provides practical recommendations for the clinician based on empirical and clinical experience. This safe, cost-free, nonpharmacologic way of managing pain has been found to reduce anxiety and depression, improve physical capacity, increase functioning and independence, and reduce morbidity and mortality. Content Type Journal ArticleCategory Psychiatric Management of Pain (MR Clark, Section Editor)Pages 1-9DOI 10.1007/s11916-012-0245-3Authors Amy Burleson Sullivan, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Mail Code U10, 9500 Euclid Avenue, Cleveland, OH 44195, USAJudith Scheman, Neurological Center for Pain, Cleveland Clinic, Mail Code C21, 9500 ...

Effect of running therapy on depression (EFFORT-D). Design of a randomised controlled trial in adult patients [ ISRCTN 1894]

BMC Public Health - Latest articles — Thu, 19 Jan 2012 05:00:00 +0100

The objective of the present article is to describe the design of a RCT examining the effect of exercise on depressive patients. Methods: The EFFect Of Running Therapy on Depression in adults (EFFORT-D) is a RCT, studying the effectiveness of exercise therapy (running therapy (RT) or Nordic walking (NW)) on depression in adults, in addition to usual care. The study population consists of patients with depressive disorder, Hamilton Rating Scale for Depression (HRSD) [greater than or equal to] 14, recruited from specialised mental health care. The experimental group receives the exercise intervention besides treatment as usual, the control group receives treatment as usual. The intervention program is a group-based, 1 h session, two times a week for 6 months and of increasing intensity. The ...