MedWorm: Coeliac Disease

Celiac disease, Behcet, and idiopathic thrombocytopenic purpura in siblings of a patient with multiple sclerosis

Multiple Sclerosis — Fri, 06 Nov 2009 14:57:07 +0100

We report a 30-year-old woman with MS, the product of consanguineous marriage, and three siblings with three different autoimmune diseases: idiopathic thrombocytopenic purpura, celiac disease, and Behçet’s disease. (Source: Multiple Sclerosis)

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Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review).

International Journal of Molecular Medicine — Thu, 05 Nov 2009 12:43:01 +0100

Authors: El-Salhy M Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)-releasing effect. Ghrelin plays an important role in regulating appetite, feeding and energy metabolism. It also plays a role in mediating immune response and inflammatory processes. Ghrelin stimulates gastric motility and emptying as well as motility in the small and large intestine. Ghrelin has been reported to be affected in several gastrointestinal diseases/disorders such...

Non-Response to HBV Vaccine a Sign of Possible Celiac Disease

Medscape Medical News Headlines — Mon, 02 Nov 2009 17:52:36 +0100

Celiac disease patients often don't respond to hepatitis B virus (HBV) vaccination, leading Italian researchers to recommend that monitoring responses to the vaccine be routine in celiac patients. Reuters Health Information (Source: Medscape Medical News Headlines)

Localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers

Autonomic Neuroscience: Basic and Clinical — Mon, 02 Nov 2009 16:41:19 +0100

Abstract: Superoxide anion (O2−•) production was previously reported to be increased in celiac ganglia (CG) during DOCA–salt hypertension, possibly via activation of the reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase. This suggested a role for neuronal NADPH oxidase in autonomic neurovascular control. However, the expression and localization of NADPH oxidase in the peripheral neurons are not fully known. The purpose of this study was to examine the subcellular localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers. In rat CG, p22phox and neuropeptide Y (NPY) were colocalized in all neurons. P22phox was also localized to dorsal root ganglia (DRG) neurons that contain calcitonin gene related peptide (CGRP). In mesent...

CT enteroclysis features of uncomplicated celiac disease: retrospective analysis of 44 patients.

Radiology — Sun, 01 Nov 2009 00:00:00 +0100

CONCLUSION: CT enteroclysis may help establish a diagnosis of uncomplicated CD and may clarify the cause of nonspecific gastrointestinal symptoms in patients with unknown CD. However, future prospective trials are needed to determine the actual value of CT enteroclysis in patients with CD and validate the clinical usefulness of CT enteroclysis in the detection of unknown uncomplicated CD. PMID: 19864528 [PubMed - in process] (Source: Radiology)

Celiac disease: presentation of 109 children.

Yonsei Medical Journal — Sat, 31 Oct 2009 00:00:00 +0100

CONCLUSION: Although classical CD was seen in most patients in the present study, clinical variability of the condition should be kept in mind. PMID: 19881963 [PubMed - in process] (Source: Yonsei Medical Journal)

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Gluten: The Secret Stalker

Psychology Today Food and Diet Center — Fri, 30 Oct 2009 15:28:23 +0100

Depression is one of the symptoms of celiac disease. That's possibly because the disease causes impaired absorption of the amino acid tryptophan, which the body converts into serotonin. But psychological distress among celiac-disease patients only stands to reason, given that some of the other symptoms and effects of this incurable condition include diarrhea, abdominal pain, bloating, gas, constipation, irritable bowel syndrome, failure to thrive in infancy, vomiting, short stature, iron deficiency with or without anemia, poor performance in school, delayed puberty, infertility, recurrent miscarriage, osteoporosis, vitamin deficiencies, fatigue, tooth discoloration and dental enamel defects, skin disorders, elevated liver enzymes, Down syndrome, Sjogren's syndrome, canker sores, arthritis,...

Use of MHC II Structural Features in the Design of Vaccines for Organ-Specific Autoimmune Diseases.

Current Pharmaceutical Design — Thu, 29 Oct 2009 17:30:04 +0100

Authors: Moustakas AK, Papadopoulos GK The Major Histocompatibility Complex Class II locus is the primary genetic linkage to autoimmune diseases. Susceptibility to each such disease is linked to different alleles, with a few alleles showing also dominant protection. The design of vaccines for autoimmune diseases is a long sought-after goal. As knowledge about the pathogenesis of these diseases has increased, the tools for such an approach have of necessity been refined. We review below the structural essence of MHC II-linked autoimmune diseases which centers on the binding of antigenic peptides to the disease-linked MHC II proteins, and the consequent activation of cognate TCRs from pathogenic CD4(+) T cells. The state of affairs in two organ-specific autoimmune diseases, type 1 diabet...

Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis

FEBS Journal — Thu, 29 Oct 2009 00:00:00 +0100

The multifunctional tissue transglutaminase 2 (TG2) has a four-domain structure with several Ca2+-regulated biochemical activities, including transglutamylation and GTP hydrolysis. The structure of the Ca2+-binding form of the human enzyme is not known, and its Ca2+-binding sites have not been fully characterized. By mutagenesis, we have targeted its active site Cys, three sites based on homology to Ca2+-binding residues of epidermal transglutaminase and factor XIIIa (S1[ndash]S3), and two regions with negative surface potentials (S4 and S5). CD spectroscopy, antibody-binding assay and GTPase activity measurements indicated that the amino acid substitutions did not cause major structural alterations. Calcium-45 equilibrium dialysis and isothermal calorimetric titration showed that both wil...

CT Enteroclysis Features of Uncomplicated Celiac Disease: Retrospective Analysis of 44 Patients [Gastrointestinal Imaging]

Radiology — Wed, 28 Oct 2009 16:04:57 +0100

Besides the classical reversed jejunoileal fold pattern, CT enteroclysis shows a constellation of findings in association with uncomplicated celiac disease. (Source: Radiology)

Gluten-Free Doesn't Have to Be Flavor-Free

Health News: CBSNews.com — Wed, 28 Oct 2009 14:00:03 +0100

"The Gluten-Free" Chef Shares Recipes Celiac Disease Sufferers Can Enjoy (Source: Health News: CBSNews.com)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring

JDDG — Wed, 28 Oct 2009 00:00:00 +0100

Conclusions: The detection of IgA autoantibodies against epidermal transglut-aminase is the most sensitive serological test in the diagnosis of dermatitis herpetiformis. Our observations confirm that patients with dermatitis herpetiformis usually do not demonstrate apparent gastrointestinal symptoms. (Source: JDDG)

Is Duodenal Biopsy Necessary In Celiac Disease Diagnosis For Children And Adults?

Health News from Medical News Today — Mon, 26 Oct 2009 08:00:00 +0100

Duodenal biopsy remains the gold standard for celiac disease (CD) diagnosis. However, it has several pitfalls and requires an invasive procedure in children. In the past few years, a more prominent role for a definitive diagnosis based solely on serology has been proposed. (Source: Health News from Medical News Today)

How coeliac disease left Hotel Babylon star Michael Obiora slurring his speech

the Mail online | Health — Sat, 24 Oct 2009 20:56:35 +0100

Hotel Babylon viewers never guessed that Michael Obiora, who played flamboyant receptionist Ben Trueman, was battling an incurable disease. (Source: the Mail online | Health)

Variable biopsy findings common in childhood celiac disease

MedWire News - Pediatrics — Fri, 23 Oct 2009 13:56:00 +0100

Duodenal involvement in children with celiac disease is often patchy and may show variable severity even within a single biopsy fragment, say researchers who say multiple endoscopic biopsies are necessary to diagnose the condition. (Source: MedWire News - Pediatrics)

Variable biopsy findings common in childhood celiac disease

MedWire News - Gastroenterology — Fri, 23 Oct 2009 13:11:24 +0100

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Is duodenal biopsy necessary in celiac disease diagnosis for children and adults?

EurekAlert! - Medicine and Health — Thu, 22 Oct 2009 04:00:00 +0100

(World Journal of Gastroenterology) A research team from Spain evaluated the predictive value of tissue transglutaminase (tTG) antibodies for villous atrophy in adult and pediatric populations to determine if duodenal biopsy can be avoided. They found strongly positive tTG antibody titers might be sufficient for celiac disease diagnosis in children. However, duodenal biopsy cannot be avoided in adults because disease presentation and monitoring are different. (Source: EurekAlert! - Medicine and Health)

Extensive lymphadenectomy in colorectal cancer with isolated para-aortic lymph node metastasis below the level of renal vessels

Journal of Surgical Oncology — Mon, 19 Oct 2009 23:00:00 +0100

The effects of isolated metastatic node dissection in the para-aortic region have not been established in colorectal cancer (CRC). The authors undertook to evaluate the role of para-aortic lymph node (PALN) dissection in CRC with isolated PALN metastasis.Between January 1993 and March 2006, 24 patients underwent PALN dissection for isolated PALN metastasis from CRC. Patients with distant metastases other than to PALNs, or with nodal metastasis above the celiac axis were excluded. The control group was composed of 53 patients with isolated PALN metastasis below the level of the renal hilum that was not surgically removed.Median disease-free interval after PALN dissection was 14 months. The postoperative complication rate was 27.8%, which was not significantly different from that of the cont...

Neurological symptoms in patients with biopsy proven celiac disease

Movement Disorders — Mon, 19 Oct 2009 23:00:00 +0100

In celiac disease (CD), the gut is the typical manifestation site but atypical neurological presentations are thought to occur in 6 to 10% with cerebellar ataxia being the most frequent symptom. Most studies in this field are focused on patients under primary neurological care. To exclude such an observation bias, patients with biopsy proven celiac disease were screened for neurological disease. A total of 72 patients with biopsy proven celiac disease (CD) (mean age 51 ± 15 years, mean disease duration 8 ± 11 years) were recruited through advertisements. All participants adhered to a gluten-free diet. Patients were interviewed following a standard questionnaire and examined clinically for neurological symptoms. Medical history revealed neurological disorders such as migraine (28%), carpa...

Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice

BMC Gastroenterology — Thu, 15 Oct 2009 23:00:00 +0100

Conclusion: The lesion in celiac disease in children can be patchy with duodenal bulb mucosa being the only area showing histological changes. The recommendations regarding the site of biopsies should be revised to include biopsies not only from distal duodenum but also from bulb to improve the diagnostic yield. (Source: BMC Gastroenterology)

Coeliac sprue-associated membranoproliferative glomerulonephritis (MPGN)

Nephrology Dialysis Transplantation — Thu, 15 Oct 2009 08:26:24 +0100

Coeliac sprue (CS) may occur in association with immune complex-mediated diseases, including IgA nephropathy, dermatitis herpetiformis and thyroiditis. An association of CS with membranoproliferative glomerulonephritis (MPGN) type 1 is rare, with only two prior cases reported. Here we describe a 45-year-old man with no prior medical history who presented initially with microhaematuria, subnephrotic proteinuria and hypocomplementaemia. A renal biopsy revealed MPGN type 1 with negative serologic workup for secondary causes. The patient was treated conservatively with angiotensin-converting enzyme inhibitors. Several months later, he developed daily non-bloody diarrhoea and was found to have worsening hypoalbuminaemia, hypophosphataemia and severe iron deficiency anaemia. A diagnosis of CS wa...

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Duodenal biopsy may be avoided when high transglutaminase antibody titers are present.

World Journal of Gastroenterology : WJG — Tue, 13 Oct 2009 23:00:00 +0100

CONCLUSION: Strongly positive tTG antibody titers might be sufficient for CD diagnosis in children. However, duodenal biopsy cannot be avoided in adults because disease presentation and monitoring are different. PMID: 19824110 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Adult celiac disease with acetylcholine receptor antibody positive myasthenia gravis.

World Journal of Gastroenterology : WJG — Tue, 13 Oct 2009 23:00:00 +0100

Authors: Freeman HJ, Gillett HR, Gillett PM, Oger J Celiac disease has been associated with some autoimmune disorders. A 40-year-old competitive strongman with celiac disease responded to a gluten-free diet, but developed profound and generalized motor weakness with acetylcholine receptor antibody positive myasthenia gravis, a disorder reported to occur in about 1 in 5000. This possible relationship between myasthenia gravis and celiac disease was further explored in serological studies. Frozen stored serum samples from 23 acetylcholine receptor antibody positive myasthenia gravis patients with no intestinal symptoms were used to screen for celiac disease. Both endomysial and tissue transglutaminase antibodies were examined. One of 23 (or, about 4.3%) was positive for both IgA-endomysi...

Haematological manifestation of coeliac disease in a young patient with myocardial infarction

Internal Medicine Journal — Tue, 13 Oct 2009 23:00:00 +0100

(Source: Internal Medicine Journal)

Uveitis in celiac disease with an excellent response to gluten-free diet: third case described

Rheumatology International — Tue, 13 Oct 2009 21:04:50 +0100

Abstract To describe the case of a patient with celiac disease who achieved a complete response to a gluten-free diet. A 28-year-old woman presented with diarrhea, oral ulcers, and refractory uveitis of 2.5-years duration. She was treated with prednisone, mydriatic drops, and infliximab with no response. She was referred to our hospital at which point her previous diagnosis of uveitis was confirmed; she was also diagnosed with right-sided sacro-iliitis. The patient did not have arthritis or any skin conditions. Three tests for fecal parasites and a fecal leukocyte were negative. Endoscopy revealed atrophic appearance of the duodenal mucosa. Biopsy showed atrophy of the duodenal villi with intra-epithelial lymphocytes, hyperplasia of the crypts, and chronic inflammatory inf...

Implications of mass screening for childhood celiac disease

Future Medicine: Pediatric Health — Tue, 13 Oct 2009 16:25:48 +0100

Pediatric Health , October 2009, Vol. 3, No. 5, Pages 413-415. (Source: Future Medicine: Pediatric Health)

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Behçet’s disease and celiac disease: a rare association or a possible link?

Rheumatology International — Tue, 13 Oct 2009 08:15:48 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00296-009-1173-3Authors Ludovico Abenavoli, University “Magna Græcia” Department of Experimental and Clinical Medicine Viale Europa 88100 Catanzaro Italy Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)

Antibodies to human tissue transglutaminase and alterations of vitamin D metabolism in ankylosing spondylitis and psoriatic arthritis

Rheumatology International — Tue, 13 Oct 2009 08:15:44 +0100

Abstract Both in ankylosing spondylitis (ASP) and psoriatic arthritis (PsA), osteopenia is present in one-third of women and men, whereas osteoporosis mainly affects men, even in their 30 s. Subclinical gut inflammation has been described in patients with AS or PsA. Joint involvement also occurs with other gastrointestinal diseases such as celiac disease. We tested the hypothesis, whether elevated serum levels of human anti-tissue-transglutaminase-IgA (htTG) are associated with changes in disease activity, vitamin D metabolism and bone mineral density (BMD) in patients with ASP and PsA. In a cross-sectional study, we evaluated both biochemical markers of bone turnover, BMD and htTG in 76 patients with ASP and 120 patients with PsA. A reduction of BMD in lumbar spine w...

Quality characteristics and storage stability of baked and fried chicken nuggets formulated with wheat and rice flour

Journal of Food Quality — Mon, 12 Oct 2009 23:00:00 +0100

A randomized complete block design was utilized to evaluate the effects of baking and frying on the quality and sensory acceptability of chicken nuggets formulated with rice and wheat flour. It was also determined if reheating method (baking versus microwaving) affected sensory quality and if storage time (90 days) impacted product quality. Substitution of wheat flour with rice flour did not affect (P > 0.05) product quality or consumer acceptability, but frying improved (P < 0.05) sensory acceptability when compared with baking. Sensory descriptors and acceptability testing revealed that microwave reheating negatively affected baked treatments but did not impact fried treatments. Chicken nugget treatments could be stored for 90 days without negatively affecting product quality. This resea...

Microfluorimeter with disposable polymer chip for detection of coeliac disease toxic gliadin

RSC - Lab Chip latest articles — Sun, 11 Oct 2009 23:00:00 +0100

Teresa Mairal, Ines Frese, Enrique Llaudet, Carmen Bermudo Redondo, Ioanis Katakis, Frithjof von Germar, Klaus Drese, Ciara K. O' Sullivan (Paper from Lab Chip) Teresa Mairal, Lab Chip, 2009, DOI: 10.1039/b914635k To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)

Gluten-free Diet Reduces Bone Problems In Children With Celiac Disease, Study Finds

ScienceDaily Headlines — Sat, 10 Oct 2009 15:00:00 +0100

Celiac disease (CD) is an inherited intestinal disorder characterized by life-long intolerance to the ingestion of gluten, a protein found in wheat, rye, and barley. Although CD can be diagnosed at any age, it commonly occurs during early childhood. Reduced bone mineral density is often found in individuals with CD. A new article examines the literature on the topic and reveals that a gluten-free diet can affect children's recovery. (Source: ScienceDaily Headlines)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

In Children With Celiac Disease, Gluten-Free Diet Reduces Bone Problems

Health News from Medical News Today — Sat, 10 Oct 2009 07:00:00 +0100

Celiac disease (CD) is an inherited intestinal disorder characterized by life-long intolerance to the ingestion of gluten, a protein found in wheat, rye, and barley. Although CD can be diagnosed at any age, it commonly occurs during early childhood (between 9 and 24 months). Reduced bone mineral density is often found in individuals with CD. (Source: Health News from Medical News Today)

Autoimmune reaction may explain osteoporosis in celiac disease patients

MedWire News - Bone Health — Fri, 09 Oct 2009 10:09:23 +0100

UK research suggests that osteoporosis in patients with celiac disease may be due to an immune response against osteoprotegerin, a cytokine that blocks bone resorption. (Source: MedWire News - Bone Health)

Genetic Test for Celiac Disease Is Marketed Directly to Consumers Via Internet

Dark Daily — Fri, 09 Oct 2009 09:30:56 +0100

Prometheus Laboratories targets millions of individuals with undiagnosed celiac disease Direct-to-consumer (DTC) testing for celiac disease is now a reality. One company is now marketing a saliva-based genetic test that allows a patient to request, administer, and check the results of the test without leaving his or her home! The market for this test is substantial. According [...] (Source: Dark Daily)

Celiac Disease Is A Silent Killer-Phadia To Launch Two New, Technologically-Advanced Diagnostic Tests

Health News from Medical News Today — Fri, 09 Oct 2009 07:00:00 +0100

Phadia Inc., worldwide leaders in the development, manufacturing and marketing of complete blood test systems for the clinical diagnosis and monitoring of allergy, asthma and autoimmune diseases, announced the launch of a two new, highly -reliable assays to support the accurate diagnosis of celiac disease. (Source: Health News from Medical News Today)

New Link Found Between Osteoporosis And Coeliac Disease

Health News from Medical News Today — Fri, 09 Oct 2009 07:00:00 +0100

People with coeliac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown. It is the first time an autoimmune response - a condition whereby the body can attack itself - has been shown to cause damage to bones directly. (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

[Dilated myocardiopathy as a form of presentation of coeliac disease in childhood.]

Anales de Pediatria — Thu, 08 Oct 2009 23:00:00 +0100

Authors: Vázquez Gomis RM, Izquierdo Fos I, Zapata A, Parra G, Chicano Marin FJ PMID: 19819771 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)

Immune system link in celiac disease, bone loss

CBC | Health — Thu, 08 Oct 2009 18:18:57 +0100

People with celiac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a new study suggests. (Source: CBC | Health)

New Link Found Between Osteoporosis And Celiac Disease

ScienceDaily Headlines — Thu, 08 Oct 2009 10:54:58 +0100

People with celiac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown. (Source: ScienceDaily Headlines)

Gluten-free diet reduces bone problems in children with celiac disease

EurekAlert! - Medicine and Health — Thu, 08 Oct 2009 04:00:00 +0100

(Wiley-Blackwell) Celiac disease (CD) is an inherited intestinal disorder characterized by life-long intolerance to the ingestion of gluten, a protein found in wheat, rye, and barley. Although CD can be diagnosed at any age, it commonly occurs during early childhood. Reduced bone mineral density is often found in individuals with CD. A new article in the journal Nutrition Reviews examines the literature on the topic and reveals that a gluten-free diet can affect children's recovery. (Source: EurekAlert! - Medicine and Health)

Evaluation of GH-IGF-I Axis in Adult Patients with Coeliac Disease

Hormone and Metabolic Research — Thu, 08 Oct 2009 00:48:13 +0100

In conclusion, a significant number of adult coeliac patients show an impaired GH secretion, this alteration being predominant in males and independent from disease onset and diet regimen. Given the absence of APAs, the cause of this pituitary dysfunction remains unclear even if a previous autoimmune involvement in some cases cannot be excluded.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)

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Coeliac bone loss link uncovered

BBC News | Health | UK Edition — Thu, 08 Oct 2009 00:11:06 +0100

People with coeliac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a study suggests. (Source: BBC News | Health | UK Edition)

Gluten-Free Diet Reduces Bone Problems in Children with Celiac Disease

Diabetes News from dLife.com — Wed, 07 Oct 2009 23:00:00 +0100

October 8, 2009 (EurekAlert) - Celiac disease (CD) is an inherited intestinal disorder characterized by life-long intolerance to the ingestion of gluten, a protein found in wheat, rye, and barley. Although CD can be diagnosed at any age, it commonly occurs during early childhood (between 9 and 24 months). Reduced bone mineral density is often found in individuals with CD. A new article in the journal Nutrition Reviews examines the literature on the topic and reveals that a gluten-free diet can affect children's recovery. Metabolic bone disease remains a significant and common complication of CD. Reduced bone mineral density can lead to the inability to develop optimal bone mass in children and the loss of bone in adults, both of which increase the risk of osteoporosis. There also exist...

Gluten-Free Diet Reduces Bone Problems in Children with Celiac Disease

Diabetes News from dLife.com — Wed, 07 Oct 2009 23:00:00 +0100

New link found between osteoporosis and coeliac disease

EurekAlert! - Medicine and Health — Wed, 07 Oct 2009 04:00:00 +0100

(University of Edinburgh) People with coeliac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown. (Source: EurekAlert! - Medicine and Health)

Autoantibodies Against Osteoprotegerin Examined

Modern Medicine — Tue, 06 Oct 2009 23:00:00 +0100

A case of osteoporosis with high bone turnover in a relatively young man with celiac disease suggests a possible role for autoantibodies against osteoprotegerin in osteoporosis in patients with this condition, according to research published in the Oct. 8 issue of the New England Journal of Medicine. (Source: Modern Medicine)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Brief Report: Osteoporosis Associated with Neutralizing Autoantibodies against Osteoprotegerin

New England Journal of Medicine — Tue, 06 Oct 2009 23:00:00 +0100

Autoantibodies against osteoprotegerin, blocking the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor {kappa}B, were identified in a man with celiac disease who presented with severe osteoporosis and high levels of markers of bone turnover. The osteoporosis did not respond to treatment of his celiac disease but was completely reversed by bisphosphonate therapy. (Source: New England Journal of Medicine)

A regulatory SNP in Ubiquitin D gene associated with celiac disease.

Human Immunology — Fri, 02 Oct 2009 23:00:00 +0100

Authors: Castellanos-Rubio A, Santin I, Irastorza I, Sanchez-Valverde F, Castaño L, Vitoria JC, Bilbao JR An aberrant immune response triggered by dietary gluten is the main driving force underlying celiac disease (CD), but other biological pathways that are dysregulated also participate in disease development. Genetic variation within these pathways might influence expression, contributing to susceptibility to CD. We have investigated the implication of ubiquitin D (UBD), a member of the ubiquitin-proteasome system that is strongly upregulated in the intestinal mucosa of active CD. RT-PCR analysis of intestinal biopsy sample pairs (at diagnosis vs. treated) from 30 CD patients confirmed overexpression of UBD in active disease tissue (fold change=8.3; p =0.0022). In silico predict...

Dr. Myron Levine Is Recpient of UMB's 2009 Entrepreneur of the Year Award

University of Maryland School of Medicine News Headlines — Fri, 02 Oct 2009 00:00:00 +0100

"It's been a fantastic run," Myron M. "Mike" Levine, MD, DTPH, said at his Entrepreneur of the Year presentation Oct. 1 before a packed auditorium at the University of Maryland BioPark. Thirty-five years after founding the University of Maryland School of Medicine's Center for Vaccine Development (CVD), Dr. Levine is known worldwide for his role in developing vaccines to prevent the spread of diseases such as cholera, typhoid fever, and Shigella dysentery. The CVD currently is working on an H1N1 vaccine, and evaluating one for malaria. In his presentation "Vaccines, Global Health, and Social Equity," Dr. Levine recapped his years of research, which have taken him from advising prestigious universities, including Oxford and Harvard, to working in extremely remote locations in developing c...

Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease.

World Journal of Gastroenterology : WJG — Thu, 01 Oct 2009 22:20:53 +0100

Authors: De Nitto D, Monteleone I, Franzè E, Pallone F, Monteleone G Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra-epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD. Extensive studies of molecules produced by immune cells in the gut of CD patients have led to identification of two cytokines, namely interleukin (IL)-15 and IL-21, which are thought to play a major role in orchestrating the mucosal inflammatory response in CD. Here we review t...

A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases.

World Journal of Gastroenterology : WJG — Thu, 01 Oct 2009 22:20:42 +0100

Authors: Bermejo F, García-López S Iron deficiency (ID), with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

A short review of malabsorption and anemia.

World Journal of Gastroenterology : WJG — Thu, 01 Oct 2009 22:20:40 +0100

Authors: Fernández-Bañares F, Monzón H, Forné M Anemia is a frequent finding in most diseases which cause malabsorption. The most frequent etiology is the combination of iron and vitamin B12 deficiency. Celiac disease is frequently diagnosed in patients referred for evaluation of iron deficiency anemia (IDA), being reported in 1.8%-14.6% of patients. Therefore, duodenal biopsies should be taken during endoscopy if no obvious cause of iron deficiency (ID) can be found. Cobalamin deficiency occurs frequently among elderly patients, but it is often unrecognized because the clinical manifestations are subtle; it is caused primarily by food-cobalamin malabsorption and pernicious anemia. The classic treatment of cobalamin deficiency has been parenteral administration of t...

Video: Why Common Foods May Hurt Your Health

Health News: CBSNews.com — Thu, 01 Oct 2009 12:23:13 +0100

For every 100 people in the U.S. who have celiac disease, only three have been diagnosed. Dr. Jon LaPook talks with an expert about what the disease is and who should be tested. (Source: Health News: CBSNews.com)

Video: Why Common Foods May Hurt Your Health

Health News: CBSNews.com — Thu, 01 Oct 2009 12:23:13 +0100

A deregulated immune response to gliadin causes a decreased villus height in dq8 transgenic mice.

European Journal of Immunology — Tue, 29 Sep 2009 23:00:00 +0100

Authors: D'Arienzo R, Stefanile R, Maurano F, Luongo D, Bergamo P, Mazzarella G, Troncone R, Auricchio S, David C, Rossi M Celiac disease (CD) is an enteropathy triggered by gluten and mediated by CD4+T cells. A complete understanding of CD immunopathogenesis has been hindered due to the lack of adequate in vivo models. Herein, we explored the effect of the inhibition of cyclooxygenases (COXs) by indomethacin in wheat gliadin-sensitized transgenic mice expressing the HLA-DQ8 heterodimer, a molecule associated with CD. Treated mice showed a gliadin-specific immune response with a significant reduction of villus height, not linked to crypt hyperplasia and to expansion of intraepithelial T cells. Notably, treated mice showed increased numbers of CD25(+) and apoptotic cells in the lamina p...

A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice

European Journal of Immunology — Tue, 29 Sep 2009 23:00:00 +0100

Celiac disease (CD) is an enteropathy triggered by gluten and mediated by CD4+T cells. A complete understanding of CD immunopathogenesis has been hindered due to the lack of adequate in vivo models. Here, we explored the effect of the inhibition of COX by indomethacin in wheat gliadin-sensitized transgenic mice expressing the HLA-DQ8 heterodimer, a molecule associated with CD. Treated mice showed a gliadin-specific immune response with a significant reduction of villus height, not linked to crypt hyperplasia and to expansion of intraepithelial T cells. Notably, treated mice showed increased numbers of CD25+ and apoptotic cells in the lamina propria, whereas high basal levels of IFN-[gamma] secretion, along with a reduced gliadin-specific IL-2 expression were detected in MLN. Biochemical as...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Study Finds Increased Risk Of Death For Patients With Celiac Disease-related Disorders

ScienceDaily Headlines — Tue, 29 Sep 2009 03:00:00 +0100

New research indicates that patients with lesser degrees of celiac disease-related symptoms, such as intestinal inflammation or latent celiac disease, have a modestly increased risk of death, according to a new study. (Source: ScienceDaily Headlines)

University of Maryland School of Medicine Scientists Pinpoint Critical Molecule to Celiac, Possibly Other Autoimmune Disorders

University of Maryland School of Medicine News Headlines — Tue, 29 Sep 2009 00:00:00 +0100

Findings Reveal Further Detail About Protein Linked to Inflammatory Disorders It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes. Now, scientists have solved the mystery of zonulin’s identity, putting a face to the name, in a sense. Scientists led by Alessio Fasano, M.D., have identified zonulin as a molecule in the human body called haptoglobin 2 precursor. Pinpointing the precise molecule that makes up the mysterious protein will enable a more detailed and thorough study of zonulin and its relationship to a series of inflammatory disorders. The discovery was reported in a new study ...

Use of likelihood ratios improves clinical interpretation of IgA anti-tTG antibody testing for celiac disease.

International Journal of Clinical Chemistry — Mon, 28 Sep 2009 23:00:00 +0100

CONCLUSION: Sensitivity of IgA anti-tTG was good. Specificity, however, was reduced when IgA anti-tTG was weak positive or when the IgA concentration was increased. Taking into account IgA anti-tTG concentration and IgA concentration improves clinical interpretation of serologic testing for CD. PMID: 19799890 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)

Cavernous transformation of the portal vein

Pediatric Radiology RSS News, Cases, Teaching Files and Publications — Mon, 28 Sep 2009 17:34:31 +0100

17 year-old male. Unspecific immune defect with multiple organ manifestations (juvenile chronic arthritis, factor V mutation, ulcerative colitis, autoimmune hepatitis, retarded growth, celiac disease... (Source: Pediatric Radiology RSS News, Cases, Teaching Files and Publications)

Pathogenesis and Management of Iron Deficiency Anemia: Emerging Role of Celiac Disease, Helicobacter pylori, and Autoimmune Gastritis

Seminars in Hematology — Mon, 28 Sep 2009 16:46:58 +0100

The causes of iron deficiency vary significantly during different stages of life, and according to gender and socioeconomic circumstances. Although dietary iron is important, iron deficiency anemia (IDA) is mostly attributed to blood loss and may be the presenting clinical feature of occult bleeding from the gastrointestinal (GI) tract heralding underlying malignancy. Conventional GI diagnostic workup fails to establish the cause of iron deficiency in about one third of patients. However, abnormal iron absorption caused by hereditary iron-refractory iron deficiency anemia (IRIDA) or acquired disease is increasingly recognized as an important cause of unexplained iron deficiency. The recent availability of convenient, non-invasive screening methods to identify celiac disease, autoimmune atr...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Recalcitrant Vomiting, Disturbed Eye Movements, and Leukoencephalopathy

Gastroenterology — Mon, 28 Sep 2009 00:00:00 +0100

Question: A 34-year-old woman was referred for workup of severe cachexia (26 kg, 160 cm; body mass index, 10.2 kg/m2; highest weight, 40 kg), new-onset intractable vomiting and upper abdominal pain. She had initially undergone operative exploration at another hospital owing to high-grade gastric and proximal small bowel dilatation on abdominal CT scan ( A). However, mechanical obstruction was excluded at surgery. On admission to our department, physical examination was pertinent for hyperactive bowel sounds and a scaphoid abdomen painful on gentle palpation. Neurological evaluation disclosed discrete bilateral ptosis with horizontal ( B) and vertical ophthalmoparesis as well as pallhypaesthesia in the right foot. Liver enzymes were significantly elevated (normal values in parentheses): ala...

Psyllium as a Substitute for Gluten in Bread

Journal of the American Dietetic Association — Fri, 25 Sep 2009 16:56:20 +0100

This study is experimental and was subdivided into five steps: selection and development of preparation, chemical analysis, sensory analysis, and statistical analysis. Modified samples of the bread dough achieved a 93.0% acceptance rate for individuals with celiac disease and up to 97.0% for individuals without celiac disease. The most affected characteristics were odor and texture. In terms of chemical composition of the bread dough, energy was reduced by 32.1% and the fat fraction was 42.3% before being cooked. Data obtained from sensory analysis of psyllium doughs indicate that the products had good acceptance by individuals with celiac disease as well as by individuals without celiac disease. This suggests that psyllium can replace gluten in preparations. Furthermore, in terms of chemi...

Mary M. Niewinski, MS, RD, and Patricia M. Guenther, PhD, RD, Win Huddleson Award

Journal of the American Dietetic Association — Fri, 25 Sep 2009 16:56:20 +0100

Mary M. Niewinski MS, RD, is one of two recipients of this year's 26th annual Huddleson Award for the article “Advances in Celiac Disease and Gluten-Free Diet,” which was featured in the April 2008 issue of the Journal of the American Dietetic Association (2008;108:661-672). (Source: Journal of the American Dietetic Association)

Metabolic osteopathy in celiac disease: importance of a gluten-free diet

Nutrition Reviews — Wed, 23 Sep 2009 23:00:00 +0100

Reduced bone mineral density (BMD) is frequently found in individuals with untreated celiac disease (CD), possibly due to calcium and vitamin D malabsorption, release of pro-inflammatory cytokines, and misbalanced bone remodeling. A gluten-free diet (GFD) promotes a rapid increase in BMD that leads to complete recovery of bone mineralization in children. Children may attain normal peak bone mass if the diagnosis is made and treatment is given before puberty, thereby preventing osteoporosis in later life. A GFD improves, but rarely normalizes, BMD in patients diagnosed with CD in adulthood. In some cases, nutritional supplementation may be necessary. More information on therapeutic alternatives is needed. (Source: Nutrition Reviews)

Performance of Serology Assays for Diagnosing Celiac in a Clinical Setting.

Clinical and Vaccine Immunology — Tue, 22 Sep 2009 23:00:00 +0100

We examined differences between younger and older children in terms of clinical presentation, test performance and the ability of high antibody levels to correctly predict celiac diagnosis. Celiac was diagnosed in 85 (73%) children. No significant clinical differences were observed between the biopsy positive and biopsy negative groups. Children </=3 years of age revealed higher concentrations of tTG-IgA and DGP Ab's versus >3 years old (p=0.017 and 0.007, respectively). High antibody concentrations were predictive of villous atrophies with sensitivities ranging from 92.8% to 97.9%, depending on assay and cut-off points applied. Sensitivities, specificities, positive predictive values (PPV) and negative predictive values (NPV) varied among assays and improved after correcting for bes...

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Chili Chemical May Cut Cell Harm

WSJ.com: Health — Mon, 21 Sep 2009 23:18:50 +0100

The Research Report looks at capsaicin for heart recovery, antibiotics online, celiac damage, and more. (Source: WSJ.com: Health)

Chili Chemical May Cut Cell Harm

WSJ.com: Health — Mon, 21 Sep 2009 23:18:50 +0100

The Research Report looks at capsaicin for heart recovery, antibiotics online, celiac damage, and more. (Source: WSJ.com: Health)

Will “Just a Little” Gluten on 1 or 2 Outings a Year Harm a Teen With Celiac Disease?

Consultant Live — Mon, 21 Sep 2009 12:00:00 +0100

My teenaged patient has celiac disease and type 1 diabetes, both of which are well controlled. The patient’s mother is concerned that her son’s risk of a bowel malignancy or other celiac-related complication later in life would be significantly increased if he ingested small amounts of gluten for 5 to 7 days while at camp or on a church trip. As a result, the youngster is not allowed to participate in such outings, since it is not always possible to pack one’s own food for such trips and the available food options are usually limited. (Source: Consultant Live)

CT-Guided Biopsy of Perivascular Tumor Encasement Using Simultaneous IV Contrast Enhancement

American Journal of Roentgenology — Sun, 20 Sep 2009 23:00:00 +0100

CONCLUSION. Diagnostic biopsy specimens can be obtained safely using simultaneous IV contrast-enhanced CT guidance during difficult biopsies of unresectable tumors encasing the celiac, superior mesenteric, or left renal arteries. (Source: American Journal of Roentgenology)

A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring.

World Journal of Gastroenterology : WJG — Sun, 20 Sep 2009 21:30:37 +0100

CONCLUSION: The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring. PMID: 19764094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Free perforation of the small intestine in collagenous sprue.

World Journal of Gastroenterology : WJG — Sun, 20 Sep 2009 21:30:23 +0100

Authors: Freeman HJ, Webber DL A 67-year-old man with celiac disease developed recurrent diarrhea, profound weakness and weight loss, with evidence of marked protein depletion. His clinical course was refractory to a strict gluten-free diet and steroid therapy. Postmortem studies led to definition of unrecognized collagenous sprue that caused ulceration and small intestinal perforation. Although PCR showed identical monoclonal T-cell populations in antemortem duodenal biopsies and postmortem jejunum, careful pathological evaluation demonstrated no frank lymphoma. Rarely, overt or even cryptic T-cell lymphoma may complicate collagenous sprue, however, small intestinal ulcers and perforation may also develop independently. The dramatic findings here may reflect an underlying or early mol...

Diabetic diarrhea

Current Gastroenterology Reports — Sun, 20 Sep 2009 05:37:42 +0100

This article focuses on the etiologies of diarrhea that are seen with higher incidence in diabetic patients. Content Type Journal ArticleDOI 10.1007/s11894-009-0054-yAuthors Milena GouldJoseph H. Sellin, Baylor College of Medicine Section of Gastroenterology 1709 Dryden Road, Suite 8.36 Houston TX 77030 USA Journal Current Gastroenterology ReportsOnline ISSN 1534-312XPrint ISSN 1522-8037 Journal Volume Volume 11 Journal Issue Volume 11, Number 5 / October, 2009 (Source: Current Gastroenterology Reports)

A Pilot Study to Evaluate the Effect of Splanchnic Nerve Stimulation on Body Composition and Food Intake in Rats

Obesity Surgery — Thu, 17 Sep 2009 12:42:48 +0100

Conclusions Splanchnic nerve stimulation decreased food intake, increased metabolic rate, and improved body composition. Content Type Journal ArticleCategory Animal ResearchDOI 10.1007/s11695-009-9963-yAuthors Xiaojun Wu, Pennington Biomedical Research Center-LSU System Baton Rouge LA 70808 USALeslie McLaughlin, Louisiana State University School of Veterinary Medicine Baton Rouge LA 70803 USAJ. Patrick Polk, Louisiana State University Baton Rouge LA 70803 USAMeghana Chalasani, Louisiana State University Baton Rouge LA 70803 USAFrank L. Greenway, LSU AgCenter Clinic Unit, Pennington Biomedical Research Center-LSU System and Human Ecology Department Baton Rouge LA 70803 USAJolene Zheng, LSU AgCenter Veterinary Science Department Baton Rouge LA 70803 USA Journal Obe...

Study Finds Increased Risk Of Death For Patients With Celiac Disease-Related Disorders

Health News from Medical News Today — Thu, 17 Sep 2009 08:00:00 +0100

Celiac disease poses slight death risk

Health News - UPI.com — Wed, 16 Sep 2009 19:14:31 +0100

OREBRO, Sweden, Sept. 16 (UPI) -- Patients with lesser degrees of celiac disease symptoms, such as intestinal inflammation, have a modestly increased risk of death, Swedish researchers say. (Source: Health News - UPI.com)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study

Virchows Archiv — Wed, 16 Sep 2009 18:50:52 +0100

Abstract Tissue transglutaminase (tTG) constitutes the main autoantigen in celiac disease (CD). The aim of the study was to clarify weather celiac disease is associated with changes in tTG expression in duodenal mucosa. Tissue transglutaminase was assessed immunohistochemically (clone CUB 7402) in duodenal biopsy specimens from 22 untreated CD patients, ten normal controls (NC) with unremarkable duodenal mucosa, and nine disease nonceliac controls (DC). In 15 CD patients duodenal biopsy specimens were repeatedly assessed after these patients had been prescribed gluten-free diet. Positive pixel count algorithm of ImageScope was used for quantitative evaluation of immunohistochemistry. Tissue transglutaminase expression in superficial epithelium differed significantly betwee...

Sourdough and cereal fermentation in a nutritional perspective.

Food Microbiology — Wed, 16 Sep 2009 15:30:19 +0100

Authors: Poutanen K, Flander L, Katina K Use of sourdough is of expanding interest for improvement of flavour, structure and stability of baked goods. Cereal fermentations also show significant potential in improvement and design of the nutritional quality and health effects of foods and ingredients. In addition to improving the sensory quality of whole grain, fibre-rich or gluten-free products, sourdough can also actively retard starch digestibility leading to low glycemic responses, modulate levels and bioaccessibility of bioactive compounds, and improve mineral bioavailability. Cereal fermentation may produce non-digestible polysaccharides, or modify accessibility of the grain fibre complex to gut microbiota. It has also been suggested that degradation of gluten may render bread bet...

Small-intestinal histopathology and mortality risk in celiac disease

NHS Evidence - Gastroenterology and liver diseases - News — Wed, 16 Sep 2009 00:00:00 +0100

(Source: NHS Evidence - Gastroenterology and liver diseases - News)

Changing Pattern in the Clinical Presentation of Pediatric Celiac Disease: A 30-Year Study

Karger Publishers — Tue, 15 Sep 2009 23:00:00 +0100

Digestion 2009;80:185-191 (DOI:10.1159/000227275) (Source: Karger Publishers)

New Clues to Risks From Celiac Disease

WebMD Health — Tue, 15 Sep 2009 22:33:16 +0100

Patients with a less severe form of celiac disease may be at a higher risk of death than those with a more severe form of the disease, a study shows. (Source: WebMD Health)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Celiac Disease Is Associated with Restless Legs Syndrome

Digestive Diseases and Sciences — Tue, 15 Sep 2009 21:48:04 +0100

Conclusion Screening for celiac disease in patients with RLS is important since this commonly overlooked silent disease may be a correctable factor for some patients with idiopathic RLS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-0943-9Authors Leonard B. Weinstock, Washington University School of Medicine Department of Internal Medicine 11525 Olde Cabin Road St. Louis MO 63141 USAArthur S. Walters, Vanderbilt University School of Medicine Department of Neurology Nashville TN USAGerard E. Mullin, Johns Hopkins School of Medicine Division of Gastroenterology Baltimore MD USAStephen P. Duntley, Washington University School of Medicine Department of Neurology St. Louis MO USA Journal Digestive Diseases and SciencesOnline ISSN 1573-25...

Complete regression of advanced esophageal cancer with abdominal bulky lymph node metastasis treated by concurrent chemoradiotherapy using docetaxel, cisplatin, and 5-fluorouracil

Esophagus — Tue, 15 Sep 2009 21:44:45 +0100

Abstract In an attempt to improve survival of patients with locally advanced esophageal cancer, chemoradiotherapy consisting of cisplatin, 5-fluorouracil (5-FU), and irradiation has recently been used. For such patients, concurrent chemoradiotherapy using docetaxel in combination with cisplatin and 5-FU has been introduced and is under evaluation. We herein report an esophageal cancer patient with concomitant distant lymph node metastasis in whom a complete response was achieved by chemoradiation therapy. A 46-year-old man was diagnosed as having stage IV A esophageal cancer with synchronous bulky metastasis in the celiac lymph node, and concurrent chemoradiotherapy was started. Chemotherapy consisting of docetaxel (30 mg/m2 on days 1, 8), cisplatin (60 mg/m2 on day 1), and...

Celiac Disease Linked to Modestly Increased Mortality

Medscape Today Headlines — Tue, 15 Sep 2009 20:33:48 +0100

A retrospective cohort study shows that the risk for death among patients with celiac disease, inflammation, or latent celiac disease is modestly increased. Medscape Medical News (Source: Medscape Today Headlines)

Celiac Disease May Raise Risk of Dying

MedlinePlus Health News — Tue, 15 Sep 2009 20:00:00 +0100

People with mild form of the digestive disorder have slightly higher death rate, study shows Source: HealthDay Related MedlinePlus Topic: Celiac Disease (Source: MedlinePlus Health News)

Gluten Sensitivity Raises Risk of Death (CME/CE)

MedPage Today Allergy — Tue, 15 Sep 2009 20:00:00 +0100

Patients with mild intestinal inflammation and gluten sensitivity are at higher risk of death, even if their symptoms are not severe enough to warrant a diagnosis of full-blown celiac disease, a new Swedish study found. (Source: MedPage Today Allergy)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Life Sciences Discovery Fund 2009 Project grant awards

EurekAlert! - Cancer — Tue, 15 Sep 2009 04:00:00 +0100

(Life Sciences Discovery Fund) Six research project grant awards totaling $5.1 million will be made to Washington life sciences organizations and their partners, the state's Life Sciences Discovery Fund announced today. The projects are aimed at improving human health and will concentrate on promoting bone healing; optimizing limb amputation procedures; enhancing cancer treatment; facilitating the validation of biomarkers; generating a wheat variety that is safe for individuals with celiac disease; and developing novel cancer chemotherapeutics. (Source: EurekAlert! - Cancer)

Study Finds Increased Risk of Death For Patients With Celiac Disease-Related Disorders

Diabetes News from dLife.com — Mon, 14 Sep 2009 23:00:00 +0100

In conclusion, we found increased [risks] for death in individuals with biopsy-verified celiac disease, inflammation, and latent celiac disease, although absolute risks were small. Individuals undergoing small-intestinal biopsy in childhood had increased [risks] for death. Cardiovascular disease and malignancy were the main causes of death in celiac disease,” the authors write. (Source: Diabetes News from dLife.com)

Study Finds Increased Risk of Death For Patients With Celiac Disease-Related Disorders

Diabetes News from dLife.com — Mon, 14 Sep 2009 23:00:00 +0100

ORIGINAL CONTRIBUTION: Small-Intestinal Histopathology and Mortality Risk in Celiac Disease

JAMA — Mon, 14 Sep 2009 23:00:00 +0100

Conclusion Risk of death among patients with celiac disease, inflammation, or latent celiac disease is modestly increased. (Source: JAMA)

EDITORIAL: Mortality in Celiac Disease, Intestinal Inflammation, and Gluten Sensitivity

JAMA — Mon, 14 Sep 2009 23:00:00 +0100

(Source: JAMA)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

JAMA PATIENT PAGE: Celiac Disease

JAMA — Mon, 14 Sep 2009 23:00:00 +0100

(Source: JAMA)

Celiac Disease Linked to Modestly Increased Death Risk

Modern Medicine — Mon, 14 Sep 2009 23:00:00 +0100

In patients with confirmed or latent celiac disease -- including those who underwent small-intestinal biopsy in childhood -- there is a modestly increased risk of death, according to a study in the Sept. 16 issue of the Journal of the American Medical Association. (Source: Modern Medicine)

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes [Medical_Sciences]

Proceedings of the National Academy of Sciences — Mon, 14 Sep 2009 23:00:00 +0100

Celiac disease (CD) is an autoimmune inflammatory disease with a relatively high prevalence especially in the western hemisphere. A strong... (Source: Proceedings of the National Academy of Sciences)

HLA Alleles May Help Stratify Celiac Disease Risk

Modern Medicine — Sun, 13 Sep 2009 23:00:00 +0100

In patients at risk for celiac disease, it's possible to stratify risk on the basis of HLA-DQ genotype, according to a study published in the September issue of Clinical Gastroenterology and Hepatology. (Source: Modern Medicine)

T-bet and pSTAT-1 expression in PBMC from coeliac disease patients: new markers of disease activity.

Clinical and Developmental Immunology — Fri, 11 Sep 2009 09:00:18 +0100

Authors: Frisullo G, Nociti V, Iorio R, Patanella AK, Plantone D, Bianco A, Marti A, Cammarota G, Tonali PA, Batocchi AP Coeliac disease (CD) is considered a T cell-mediated autoimmune disease, and up-regulation of T-bet and phosphorylated signal transducers and activators of transcription (pSTAT)1, key transcription factors for the development of T helper type 1 (Th1) cells, has been described in the mucosa of patients with untreated CD. Using transcription factor analysis, we investigated whether T-bet and pSTAT1 expressions are up-regulated in the peripheral blood of CD patients and correlate with disease activity. Using flow cytometry, we analysed T-bet, pSTAT1 and pSTAT3 expression in CD4(+), CD8(+) T cells, CD19(+) B cells and monocytes from peripheral blood of 15 untreated and 1...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Critical Molecule To Celiac Disease, Possibly Other Autoimmune Disorders, Pinpointed By UM Scientists

Health News from Medical News Today — Tue, 08 Sep 2009 08:00:00 +0100

It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes. Now, scientists have solved the mystery of zonulin's identity, putting a face to the name, in a sense. Scientists led by Alessio Fasano, M.D. (Source: Health News from Medical News Today)

Scientists Pinpoint Critical Molecule To Celiac Disease, Possibly Other Autoimmune Disorders

ScienceDaily Headlines — Mon, 07 Sep 2009 21:00:00 +0100

Scientists have uncovered a molecule critical to celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes. (Source: ScienceDaily Headlines)

UM scientists pinpoint critical molecule to celiac disease, possibly other autoimmune disorders

EurekAlert! - Medicine and Health — Mon, 07 Sep 2009 04:00:00 +0100

(University of Maryland Medical Center) Scientists at the University of Maryland School of Medicine have uncovered a molecule critical to celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes. The study, by Dr. Alessio Fasano, is being published in the Proceedings of the National Academy of Sciences the week of Sept. 7, 2009. (Source: EurekAlert! - Medicine and Health)

UM Scientists Pinpoint Critical Molecule to Celiac Disease, Possibly Other Autoimmune Disorders

University of Maryland School of Medicine News Headlines — Mon, 07 Sep 2009 00:00:00 +0100

University of Maryland School of Medicine Scientists Pinpoint Critical Molecule to Celiac, Possibly Other Autoimmune Disorders

University of Maryland School of Medicine News Headlines — Mon, 07 Sep 2009 00:00:00 +0100

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity.

Cytokine — Fri, 04 Sep 2009 23:00:00 +0100

In this study, we explored the effect of different Lactobacillus spp. and Bifidobacterium lactis in transgenic mice expressing the human DQ8 heterodimer, a HLA molecule linked to Celiac Disease (CD). In vitro analysis on immature bone marrow-derived dendritic cells (iBMDCs) showed that all strains up-regulated surface B7-2 (CD86), indicative of DC maturation, however, with different intensity. No strain induced appreciable levels of IL-10 or IL-12 in iBMDCs, whereas TNF-alpha expression was essentially elicited by Lactobacillus paracasei and Lactobacillus fermentum. Interestingly, these strains were found also to increase the antigen-specific TNF-alpha secretion in vivo, following co-administration of probiotic bacteria in mice mucosally immunized with the gluten component gliadin. Togethe...

Serum Cytokine Elevations in Celiac Disease: Association with Disease Presentation.

Human Immunology — Thu, 03 Sep 2009 23:00:00 +0100

Authors: Manavalan JS, Hernandez L, Shah JG, Konikkara J, Naiyer AJ, Roland AL, Ciaccio E, Minaya MT, Green PH, Bhagat G Celiac disease (CD) is an autoimmune disorder, which is triggered by an immune response to gluten that occurs in genetically predisposed individuals. Although considered to be a primary gastrointestinal disease, CD is now known to have widespread systemic manifestations. We attempted to define the nature and role of systemic cytokine levels in the pathophysiology of CD. Multiplex cytokine assays were performed on 4 different groups of adult patients; Patients with active CD (ACD), patients on a Gluten Free Diet (GFD) with positive TTG IgA Antibodies, patients on a GFD with negative antibodies and those with Refractory CD (RCD). The results were compared with healthy ...

Childhood chronic myeloid leukemia with celiac disease

Pediatric Blood and Cancer — Wed, 02 Sep 2009 23:00:00 +0100

No Abstract. (Source: Pediatric Blood and Cancer)

Dendritic cells in intestinal homeostasis and disease

Journal of Clinical Investigation — Wed, 02 Sep 2009 17:50:05 +0100

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy. (Source: Journal of Clinical Investigation)

[Foods formulation for people with celiac disease based on quinoa (Chenopoduim quinoa), cereal flours and starches mixtures]

Archivos Latinoamericanos de Nutricion — Tue, 01 Sep 2009 00:00:00 +0100

Authors: Del Castillo V, Lescano G, Armada M Gluten free food for people with celiac disease based on quinoa, rice and corn flours and starches, were formulated. An informatic tool (ALIM V 1.0) developed by the authors, was used for the formulation of these foods. The obtained products were pancakes, scons, precooked pizza and bread which were analyzed in their chemical composition (protein, fat, fiber, moisture, ash and carbohydrates). Water activity (aw), acceptability and texture parameters (hardness, gumminess, chewiness, adhesiveness and cohesiveness) were also determined. Commercial products (C) were taken as reference and were performed the same analysis to formulated products (F). Significant differences were found in protein, fat moisture, ash and fiber content and in most of ...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

[Letter to JMG] Association of IL18RAP and CCR3 with coeliac disease in the Spanish population

Journal of Medical Genetics — Mon, 31 Aug 2009 23:00:00 +0100

Conclusion: The association of the 3p21 genetic region with CD susceptibility in the Spanish population was confirmed. In 2q12, the initially described OR is most probably overestimated and therefore the real situation may be the existence of a genuine but weak risk factor, which generates statistical power limitations. (Source: Journal of Medical Genetics)

New Developments in Serodiagnosis of Childhood Celiac Disease

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Antibodies to deamidated gliadin present a new tool in the diagnosis of celiac disease (CD). In children, the ELISA for the determination of IgG antibodies to (deamidated) gliadin-analogous fusion peptides (GAF3X) has a superior performance compared to the ELISA for the determination of antibodies against native gliadin and is comparable to assays for IgA antibodies against tissue transglutaminase (IgA-anti-tTG). The combined investigation of IgG antibodies to GAF3X (IgG-anti-GAF3X) and IgA-anti-tTG significantly increases the fraction of children definitely identified as either CD or non-CD patients. The new IgG-anti-GAF3X ELISA was also able to detect CD in three cases of IgA deficiency and in two cases of latent CD and was also useful in the diagnosis of children younger than 2 years of...

Celiac G+ Antibody Assay for the Detection of Autoantibodies in Celiac Disease

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

In conclusion, the performance of the recently developed Celiac G+ ELISA is superior in both its sensitivity and specificity in comparison with other available synthetic gliadin peptide immunoassays. Furthermore, the IgG Celiac G+ antibody test and IgA tTG antibody test used in combination is an excellent screening algorithm for suspected cases of celiac disease. (Source: Annals of the New York Academy of Sciences)

Autoantibody Screen in Inflammatory Myopathies High Prevalence of Antibodies to Gliadin

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Conclusions: Antibodies to gliadin and tissue transglutaminase characteristic for celiac disease were elevated in patients with IM compared with controls. This may indicate a higher prevalence of gluten sensitivity or celiac disease in IM. (Source: Annals of the New York Academy of Sciences)

The Incidence of Celiac Disease Antibodies in Plasma Specimens with Low Hemoglobin Levels

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Antibodies to gliadin and tissue transglutaminase (TTG) are associated with celiac disease. Celiac patients often present with low hemoglobin levels; however, the incidence of celiac disease in patients with low hemoglobin levels is unknown. We investigated the incidence of celiac disease[ndash]associated antibodies in plasma obtained from individuals with low and normal hemoglobin levels. Our objective was to determine if antigliadin and anti-TTG antibodies are more prevalent in individuals with low hemoglobin levels than in control subjects with normal hemoglobin levels. Following IRB approval, we obtained 86 plasma specimens with hemoglobin levels less than or equal to 10 g/dL and 88 plasma specimens from individuals with hemoglobin levels greater than or equal to 13 g/dL. IgA and IgG a...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

B-Lymphocyte Stimulator and a Proliferation-Inducing Ligand Serum Levels in IgA-Deficient Patients With and Without Celiac Disease

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

IgA deficiency (IgAD) is the most common form of immunodeficiency and frequently associates with autoimmunity, especially with celiac disease (CD). The mechanisms underlying IgAD and the development of autoimmunity are still relatively unknown. Elevated B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand) serum levels characterize several autoimmune diseases. We herein investigated BLyS and APRIL serum levels in IgAD patients with and without CD and compared these patients to CD patients with normal IgA and control patients (HBDs). Compared to HBDs, IgAD patients demonstrated a significant increase of BLyS (P < 0.0001) and APRIL (P= 0.003) levels, and no differences were seen between patients with or without CD. While BLyS appeared similarly overexpressed in IgAD and ...

Galectin-10, Eosinophils, and Celiac Disease

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Celiac disease (CD) is a chronic intestinal disease caused by intolerance to dietary wheat gluten in genetically susceptible individuals. There are a number of important open questions that impede the full explanation of the pathogenesis of this disease. We analyzed protein expression pattern in gut biopsies of CD subjects. Patients were selected and grouped according to histological inflammatory degree. Groups consisted of nine individuals with CD: three patients had a Marsh 0, three a Marsh I-II, and three a Marsh III. All CD patients showed a human leukocyte antigen DQ2/8 variant. Controls were three individuals with an excluded CD diagnosis. For the first time, galectin-10 expression was found related to the histological grade (P= 0.0092) and with the number of eosinophils in the lesio...

Anti-infectious Antibodies and Autoimmune-associated Autoantibodies in Patients with Type I Diabetes Mellitus and their Close Family Members

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein-Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P= 0.001) and IgG-antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies aga...

Infections May Have a Protective Role in the Etiopathogenesis of Celiac Disease

Annals of the New York Academy of Sciences — Mon, 31 Aug 2009 23:00:00 +0100

Infectious agents have been implicated in the pathogenesis of many autoimmune diseases via various pathogenic mechanisms, such as molecular mimicry, resulting in modulation of the host's immune tolerance. In the following article we examine the association between serological evidence of past infection with Toxoplasma gondii, rubella virus, cytomegalovirus, Treponema pallidum, and Epstein[ndash]Barr virus, and the co-existence of celiac disease. Our results imply that certain infections may generate an immunological environment that disfavors future appearance of certain autoimmune conditions such as celiac disease. (Source: Annals of the New York Academy of Sciences)

Digestive and nutritional considerations in celiac disease: could supplementation help?

Alternative Medicine Review — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Malterre T Due to the increased immune activation in the intestinal tract of people with celiac disease, the digestive and absorptive processes of those affected may be compromised. Individuals with celiac disease are more susceptible to pancreatic insufficiencies, dysbiosis, lactase insufficiencies, and folic acid, vitamin B12, iron, and vitamin D deficiencies, as well as accelerated bone loss due to an increase in inflammatory signaling molecules. Beyond strict maintenance of a gluten-free diet, research has shown benefit with additional nutritional supplementation to assist in regulation of several of these complications. PMID: 19803549 [PubMed - in process] (Source: Alternative Medicine Review)

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How to Live With Celiac Disease

Wash Post Health — Mon, 31 Aug 2009 15:43:07 +0100

Receiving a disease diagnosis isn't usually a good thing. But for people who learn they have celiac disease, the news often comes as a relief. (Source: Wash Post Health)

Gastrointestinal Symptoms in Children With Type 1 Diabetes Screened for Celiac Disease

PEDIATRICS — Sun, 30 Aug 2009 23:00:00 +0100

CONCLUSIONS: Children with DM and CD have a higher frequency of gastrointestinal symptoms than their diabetic peers with negative celiac serology and are not truly asymptomatic. Institution of a GFD has a positive effect on nutritional status and symptom resolution in the short-term. (Source: PEDIATRICS)

Collagenous colitis: description of a single centre series of 83 patients.

European Journal of Internal Medicine — Sun, 30 Aug 2009 12:20:41 +0100

CONCLUSION: Collagenous colitis has a higher prevalence as usually reported. There is an association with auto-immune disorders and dysbacteriosis. PMID: 19712853 [PubMed - in process] (Source: European Journal of Internal Medicine)

Autoimmunity and Diet.

Nestle Nutrition Workshop Series. Paediatric Programme. — Sun, 30 Aug 2009 02:08:02 +0100

Authors: Cerf-Bensussan N Whether diet may influence autoimmunity has been the subject of many unsolved debates. Interestingly, growing evidence indicates a large overlap between the mechanisms controlling tolerance to dietary antigens and autoimmunity. To discuss these links, we will focus on two model human diseases. The first one is IPEX syndrome due to mutations in the X-linked foxp3 gene. Studies of this disease underscore the role of regulatory FOXP3+ T cells in controlling the reactivity against self antigens and the response to dietary proteins in humans. The second is celiac disease, a complex poly-genic disease where exposure to dietary wheat proteins can trigger an autoimmune-like attack of the intestine frequently associated with the onset of extra-digestive autoimmune diso...

'ABC' of Mucosal Immunology.

Nestle Nutrition Workshop Series. Paediatric Programme. — Sun, 30 Aug 2009 02:08:02 +0100

Authors: Brandtzaeg P Two adaptive homeostatic mechanisms normally preserve mucosal integrity: (i) immune exclusion mediated by secretory antibodies to inhibit penetration of potentially dangerous microorganisms and proteins, and (ii) immunosuppression to counteract hypersensitivity against innocuous antigens. The latter mechanism is called 'oral tolerance' when induced via the gut. Similar mechanisms are suppressive against commensal bacteria. Such two-layered anti-inflammatory defense explains why persistent allergy to dietary proteins is not more common, with the exception of gluten intolerance (celiac disease) where abrogation of mucosal homeostasis is overt. Thus, mucosally induced tolerance is generally a robust adaptive mechanism in view of the fact that a ton of food may pass a...

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Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

Nature Immunology — Sat, 29 Aug 2009 23:00:00 +0100

Authors: Lars-Egil Fallang, Elin Bergseng, Kinya Hotta, Axel Berg-Larsen, Chu-Young Kim & Ludvig M Sollid (Source: Nature Immunology)

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

Nature Immunology — Sat, 29 Aug 2009 23:00:00 +0100

Authors: Lars-Egil Fallang, Elin Bergseng, Kinya Hotta, Axel Berg-Larsen, Chu-Young Kim & Ludvig M Sollid (Source: Nature Immunology)

An adult case of celiac sprue triggered after an ileal resection for perforated Meckel's diverticulum.

World Journal of Gastroenterology : WJG — Thu, 27 Aug 2009 23:00:00 +0100

Authors: Topal F, Akbulut S, Topcu IC, Dolek Y, Yonem O Celiac disease can be triggered by upper abdominal surgery, such as vagotomy, oesophagectomy, pancreaticoduodenectomy, and gastrojejunal anastomosis. Here we report a case of a 24 year-old woman who developed celiac disease after an ileal resection for perforated Meckel's diverticula. This is the first reported celiac case that has been triggered, not by upper abdominal surgery, but after ileal resection for Meckel's diverticula. PMID: 19705507 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Treat IBS with soluble fibre

OnMedica Latest News — Thu, 27 Aug 2009 23:00:00 +0100

Irritable bowel syndrome symptoms improve with psyllium but not bran Related items from OnMedicaPeppermint oil best for irritable bowelPrimary care update: Coeliac diseaseChewing gum aids recovery from bowel surgery (Source: OnMedica Latest News)

Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.

Chemistry & Biology — Thu, 27 Aug 2009 23:00:00 +0100

Authors: Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C New tools are needed for managing celiac sprue, a lifelong immune disease of the small intestine. Ongoing drug trials are also prompting a search for noninvasive biomarkers of gluten-induced intestinal change. We have synthesized and characterized noninflammatory gluten peptide analogs in which key Gln residues are replaced by Asn or His. Like their proinflammatory counterparts, these biomarkers are resistant to gastrointestinal proteases, susceptible to glutenases, and permeable across enterocyte barriers. Unlike gluten peptides, however, they are not appreciably recognized by transglutaminase, HLA-DQ2, or disease-specific T cells. In vitro and animal studies show that the biomarkers c...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?

Health News from Medical News Today — Thu, 27 Aug 2009 12:00:00 +0100

Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. (Source: Health News from Medical News Today)

Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?

ScienceDaily Headlines — Thu, 27 Aug 2009 09:00:00 +0100

A new study found that anti-glycan antibodies were associated with celiac disease. Celiac patients with multiple anti-glycan antibodies of high titers had more frequently malabsorption than other symptoms. Contrary, presence of the anti-microbial antibodies did not show familial aggregation or association with mutations in NOD2/CARD15. Presence of anti-glycan antibodies in celiac disease is supposed secondary to the impaired gut barrier leading to sustained exposure to the gut microflora constituents via translocation. (Source: ScienceDaily Headlines)

Alvine Initiates Enrollment In Phase 2a Clinical Trial Of ALV003 For Use In The Treatment Of Celiac Disease

Health News from Medical News Today — Wed, 26 Aug 2009 13:00:00 +0100

Alvine Pharmaceuticals, Inc. announced that patient enrollment has begun in a Phase 2a, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of ALV003 for use in the treatment of celiac disease. (Source: Health News from Medical News Today)

Lymphocytic Disorders of the Gastrointestinal Tract: A Review for the Practicing Pathologist

Advances in Anatomic Pathology — Wed, 26 Aug 2009 12:37:26 +0100

Increased numbers of intraepithelial lymphocytes (lymphocytosis) can be found in the esophagus, stomach, small intestine, and colon in a variety of clinical circumstances. This review, directed at practicing pathologists, portrays the normal resident lymphocyte population in the mucosa of each segment of the digestive tract and discusses the different situations that may result in quantitative or qualitative alterations of intraepithelial lymphocytes. Esophageal lymphocytosis has not been fully characterized and its clinical significance, if any, awaits definition. Thus, this diagnosis is presently discouraged. In the stomach, it is particularly important to exclude Helicobacter pylori infection and celiac sprue before diagnosing lymphocytic gastritis. Duodenal lymphocytic infiltrates, ine...

Antimicrobial antibodies in celiac disease: Trick or treat?

EurekAlert! - Medicine and Health — Wed, 26 Aug 2009 04:00:00 +0100

(World Journal of Gastroenterology) Present study found that anti-glycan antibodies were associated with celiac disease. Celiac patients with multiple anti-glycan antibodies of high titers had more frequently malabsorption than other symptoms. Contrary, presence of the anti-microbial antibodies did not show familial aggregation or association with mutations in NOD2/CARD15. Presence of anti-glycan antibodies in celiac disease is supposed secondary to the impaired gut barrier leading to sustained exposure to the gut microflora constituents via translocation. (Source: EurekAlert! - Medicine and Health)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers.

Autonomic Neuroscience — Tue, 25 Aug 2009 23:00:00 +0100

Authors: Cao X, Demel SL, Quinn MT, Galligan JJ, Kreulen D Superoxide anion (O(2)(-*)) production was previously reported to be increased in celiac ganglia (CG) during DOCA-salt hypertension, possibly via activation of the reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase. This suggested a role for neuronal NADPH oxidase in autonomic neurovascular control. However, the expression and localization of NADPH oxidase in the peripheral neurons are not fully known. The purpose of this study was to examine the subcellular localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers. In rat CG, p22(phox) and neuropeptide Y (NPY) were colocalized in all neurons. P22(phox) was also localized to dorsal root ganglia (DRG) neurons that co...

A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury

International Immunology — Mon, 24 Aug 2009 23:00:00 +0100

Celiac disease (CD) is a multifactorial disorder influenced by environmental, genetic and immunological factors. Increasing evidence showed CTLA-4 gene as an important susceptibility locus for autoimmune disorders. A native soluble cytotoxic T-lymphocyte-associated protein-4 (sCTLA-4), lacking of transmembrane sequence, has been described in several autoimmune diseases. We aimed to evaluate the presence of increased sCTLA-4 concentration in the serum of patients with CD and the possible immunoregulatory function. Blood samples were collected from 160 CD patients; sCTLA-4 levels were evaluated by ELISA, western blot and reverse transcription–PCR. The capability of serum sCTLA-4 to modulate T-lymphocyte proliferation in vitro was evaluated by two-way mixed leukocyte reaction assay. We ...

Celiac Disease in the Elderly

Gastroenterology Clinics of North America — Sat, 22 Aug 2009 10:24:47 +0100

It has become apparent recently that celiac disease, once believed to be primarily a childhood disease, can affect people of any age. Epidemiologic studies have suggested that a substantial portion of patients are diagnosed after the age of 50. Indeed, in one study, the median age at the diagnosis was just under the age of 50 with one-third of new patients diagnosed being older than 65 years. The purpose of this review is to address the prevalence, clinical features, diagnosis, and consequences of celiac disease in the elderly. The authors also review management strategies for celiac disease and adjust these with emphasis on the particular nutritional and nonnutritional consequences or associations of celiac disease as they pertain to the elderly. (Source: Gastroenterology Clinics of North...

Anti-microbial antibodies in celiac disease: trick or treat?

World Journal of Gastroenterology : WJG — Thu, 20 Aug 2009 23:00:00 +0100

CONCLUSION: The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence. PMID: 19701969 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

A Clue to the Elusive Cause of Type 1 Diabetes: Ottawa Researchers Investigate Immune Response to Wheat

Diabetes News from dLife.com — Wed, 19 Aug 2009 23:00:00 +0100

August 20, 2009 (OHRI) - Scientists at the Ottawa Hospital Research Institute and the University of Ottawa have discovered what may be an important clue to the cause of type 1 diabetes. Dr. Fraser Scott and his team tested 42 people with type 1 diabetes and found that nearly half had an abnormal immune response to wheat proteins. The study is published in the August 2009 issue of the journal Diabetes. Early in life, the immune system is supposed to learn to attack foreign invaders such as viruses and bacteria, while leaving the body’s own tissues and harmless molecules in the environment alone (including food in the gut). When this process goes awry, autoimmune diseases and allergies can develop. Type 1 diabetes is an autoimmune disease that occurs when the immune system mistakenly a...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

A Clue to the Elusive Cause of Type 1 Diabetes: Ottawa Researchers Investigate Immune Response to Wheat

Diabetes News from dLife.com — Wed, 19 Aug 2009 23:00:00 +0100

Patient Money: The Expense of Eating With Celiac Disease

NYT — Mon, 17 Aug 2009 21:09:44 +0100

An intolerance to gluten requires a special wheat-free diet that can be costly. But some patients are finding less expensive ways to stay healthy. (Source: NYT)

Patient Money: The Expense of Eating With Celiac Disease

NYT — Mon, 17 Aug 2009 21:09:44 +0100

An intolerance to gluten requires a special wheat-free diet that can be costly. But some patients are finding less expensive ways to stay healthy. (Source: NYT)

Dr James LeFanu: diet

The Telegraph : Health Advice — Mon, 17 Aug 2009 15:02:40 +0100

We are what we eat or don't eat. (Source: The Telegraph : Health Advice)

Health News of the Day

Clinical Cases and Images — Sat, 15 Aug 2009 13:41:15 +0100

is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.Albuminuria in CHF: urinary albumin to creatinine ratio (UACR) is a powerful predictor of prognosis in heart failure. Treatment with candesartan did not reduce or prevent the development of albuminuria in CHF http://bit.ly/3AFaU1Men with low estradiol, testosterone & high sex hormone binding globulin (SHBG) more likely to suffer osteop fractures http://bit.ly/UiNgGBritons pour love on 'evil' healthcare system, defend National Health Service after U.S. criticism. CNN: British Prime Minister Gordon Brown issued a heartfelt message of support for the NHS via Twitter. http://bit.ly/BTYm2Perc...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Patient Money: The Expense of Eating With Celiac Disease

NYT > Health — Fri, 14 Aug 2009 15:19:22 +0100

An intolerance to gluten requires a special wheat-free diet that can be costly. But some patients are finding less expensive ways to stay healthy. (Source: NYT > Health)

Hypoparathyroidism and coeliac disease: a potentially dangerous combination

JRSM — Wed, 12 Aug 2009 23:00:00 +0100

(Source: JRSM)

Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA.

Cellular and Molecular Life Sciences : CMLS — Wed, 12 Aug 2009 23:00:00 +0100

Authors: Myrsky E, Caja S, Simon-Vecsei Z, Korponay-Szabo IR, Nadalutti C, Collighan R, Mongeot A, Griffin M, Mäki M, Kaukinen K, Lindfors K Celiac disease is characterized by the presence of specific autoantibodies targeted against transglutaminase 2 (TG2) in untreated patients' serum and at their production site in the small-bowel mucosa below the basement membrane and around the blood vessels. As these autoantibodies have biological activity in vitro, such as inhibition of angiogenesis, we studied if they might also modulate the endothelial barrier function. Our results show that celiac disease patient autoantibodies increase endothelial permeability for macromolecules, and enhance the binding of lymphocytes to the endothelium and their transendothelial migration when compared ...

Lack of association of NKX2-3, IRGM and ATG16L1 inflammatory bowel diseases susceptibility variants with celiac disease.

Human Immunology — Tue, 11 Aug 2009 23:00:00 +0100

In conclusion, no evidence of association with CD has been found for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1 and IRGM genes. PMID: 19683022 [PubMed - as supplied by publisher] (Source: Human Immunology)

Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?

Cancer Immunology, Immunotherapy — Tue, 11 Aug 2009 16:53:52 +0100

Abstract The appearance of vitiligo and spontaneous regression of the primary lesion in melanoma patients illustrate a relationship between tumor immunity and autoimmunity. T lymphocytes play a major role both in tumor immunity and autoimmunity. CD28, Cytotoxic T lymphocyte antigen 4 (CTLA4) and inducible costimulator (ICOS) molecules are important secondary signal molecules in the T lymphocyte activation. Single nucleotide polymorphisms (SNPs) in the CD28/CTLA4/ICOS gene region were reported to be associated with several autoimmune diseases including, type-1 diabetes, SLE, autoimmune thyroid diseases and celiac disease. In this study, we investigated the association of SNPs in the CD28, CTLA4 and ICOS genes with the risk of melanoma. We also assessed the prognostic effect...

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Hepatitis B vaccination failure in celiac disease: Is there a need to reassess current immunization strategies?

Vaccine — Mon, 10 Aug 2009 23:00:00 +0100

We report a retrospective study on celiac patients vaccinated with three doses of 10mug at 3, 5 and 11 months of age by an intramuscular injection of a recombinant hepatitis B vaccine (Engerix B). We found 30 of 60 celiac patients (50%) unresponsive to vaccination and a significant higher number of responders among patients younger than 18 months at the time of celiac disease diagnosis. Our study confirms that celiac patients have a lower percentage of response to hepatitis B vaccination than healthy subjects. These findings provide useful information to evaluate if current vaccine strategies should be reassessed and if revaccination should be recommended. PMID: 19682619 [PubMed - as supplied by publisher] (Source: Vaccine)

Sweet Syndrome Associated with Celiac Disease

American Journal of Clinical Dermatology — Mon, 10 Aug 2009 10:17:52 +0100

(Source: American Journal of Clinical Dermatology)

New Online Forum for Autoimmune Disease Patients Provides Virtual Support Groups

Diabetes News from dLife.com — Sun, 09 Aug 2009 23:00:00 +0100

August 10, 2009 (Newswise) - Patients suffering with chronic autoimmune diseases from every corner of the globe can now find one another online to provide support, share experiences, and form relationships. The new Autoimmunity Forum launched by the American Autoimmune Related Diseases Association (AARDA) is a virtual support group community nearly 400 members strong. According to AARDA Executive Director and President, Virginia T. Ladd, “Today, patient advocate groups have to find patients where they are in order to assist them in getting the support and coping mechanisms that they need. While there are more than 80 autoimmune diseases and more than 23.5 million Americans who suffer from them, finding a local support group can be quite a challenge. By providing this new online servi...

New Online Forum for Autoimmune Disease Patients Provides Virtual Support Groups

Diabetes News from dLife.com — Sun, 09 Aug 2009 23:00:00 +0100