MedWorm: Erectile Dysfunction

Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease. A study of the EULAR Scleroderma Trial and Research (EUSTAR) group

Arthritis Research and Therapy — Mon, 20 Feb 2012 05:00:00 +0100

Severe erectile dysfunction is common amongst men with systemic sclerosis, appearing relatively early after disease diagnosis and associated with age; low treatment coverage suggests increased physician awareness is required. (Source: Arthritis Research and Therapy)

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Pycnogenol(®) for the treatment of chronic disorders.

Cochrane Database of Systematic Reviews — Sun, 19 Feb 2012 18:00:03 +0100

CONCLUSIONS: Current evidence is insufficient to support Pycnogenol(®) use for the treatment of any chronic disorder. Well-designed, adequately powered trials are needed to establish the value of this treatment. PMID: 22336841 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation

Brain — Fri, 17 Feb 2012 05:00:00 +0100

The NaV1.7 sodium channel is preferentially expressed within dorsal root ganglion and sympathetic ganglion neurons and their small-diameter peripheral axons. Gain-of-function variants of NaV1.7 have recently been described in patients with painful small fibre neuropathy and no other apparent cause. Here, we describe a novel syndrome of pain, dysautonomia, small hands and small feet in a kindred carrying a novel NaV1.7 mutation. A 35-year-old male presented with erythema and burning pain in the hands since early childhood, later disseminating to the feet, cheeks and ears. He also experienced progressive muscle cramps, profound sweating, bowel disturbances (diarrhoea or constipation), episodic dry eyes and mouth, hot flashes, and erectile dysfunction. Neurological examination was normal. Phy...

Zonisamide: Erectile dysfunction: case report

Reactions — Thu, 16 Feb 2012 11:41:16 +0100

(Source: Reactions)

Study finds association between open-angle glaucoma and ED

Drug Topics - Pharmacy News — Thu, 16 Feb 2012 05:00:00 +0100

Men with erectile dysfunction (ED) also were more likely to have had open-angle glaucoma than those without ED, according to a study published in the February 12 online issue of Opthalmology. (Source: Drug Topics - Pharmacy News)

Long‐term potency preservation following brachytherapy for prostate cancer

BJU International — Thu, 16 Feb 2012 05:00:00 +0100

CONCLUSION• Increasing initial age at implant, diminished pretreatment erectile function and the use of combination therapy with EBRT and/or ADT significantly increases erectile dysfunction following brachytherapy. (Source: BJU International)

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Study finds association between open-angle glaucoma and ED

Drug Topics - Top News — Thu, 16 Feb 2012 05:00:00 +0100

Chronic diseases in elderly men: underreporting and underdiagnosis

Age and Ageing — Thu, 16 Feb 2012 05:00:00 +0100

Conclusions: the study showed a high prevalence of detrimental life style factors including smoking, excessive alcohol consumption and physical inactivity in elderly Danish men. Except for diabetes and respiratory disease, chronic diseases were underreported and in particular erectile dysfunction and osteoporosis were underdiagnosed in the study population, underlining the importance of awareness of chronic diseases among both the general population and physicians. (Source: Age and Ageing)

Sexual dysfunction in men with type 2 diabetes

Postgraduate Medical Journal — Thu, 16 Feb 2012 05:00:00 +0100

Sexual dysfunction (SD) is common in type 2 diabetic men, but few subjects are diagnosed and treated. The prevalence of diabetes mellitus is increasing worldwide. It is expected that the number of subjects suffering from SD increases in the near future. Most studies of SD in diabetic men have focused on erectile dysfunction. There is a dearth of studies in the area of the other forms of SD. SD has consequences on the psychological well-being and reproductive function. They can be the first symptom of comorbidities or a treatment side effect. Erectile dysfunction is increasingly being recognised as an early marker of organic incipient systemic disease. Evaluation for any SD includes a complete medical history, detailed sexual history, physical examination, psychosocial assessment and, somet...

Study finds association between open-angle glaucoma and ED

Modern Medicine — Thu, 16 Feb 2012 05:00:00 +0100

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Zimbabwe: 'All-Male Wellness Centres Overdue'

AllAfrica News: Health and Medicine — Wed, 15 Feb 2012 09:28:46 +0100

[The Herald] There are illnesses that we talk about. Conditions like cancer, heart problems, diabetes and thanks to various campaigns against stigma, even HIV, we can openly discuss. But there are certain conditions that the afflicted do not even admit to themselves, much less talk about them and ED, or erectile dysfunction, is one of them. (Source: AllAfrica News: Health and Medicine)

No Support Shown for the Use of Pycnogenol® for Chronic Disorders

Health Behavior News Service — Wed, 15 Feb 2012 05:25:01 +0100

02/15/2012, The Cochrane Library, The manufacturer of a dietary supplement made from French pine bark, Pycnogenol®, markets it widely for the prevention or treatment of many chronic disorders, ranging from asthma to erectile dysfunction, but a recent systematic review found no sound basis for the claims. (Source: Health Behavior News Service)

Nigeria: Firm Distributes Herbal Drug for Erectile Dysfunction

AllAfrica News: Health and Medicine — Tue, 14 Feb 2012 07:47:01 +0100

[Vanguard] Lagos - The Managing Director, Greenlife Pharmaceuticals Limited, Dr Obiora Chukwuka, says his company will distribute to the Nigerian market a new herbal drug, 'Manix', which would cure Erectile Dysfunction (ED) among men. (Source: AllAfrica News: Health and Medicine)

Intimacy-enhancement pill RegenArouse recalled, FDA says

Drug Topics - Top News — Tue, 14 Feb 2012 05:00:00 +0100

An herbal pill sold as a "natural intimacy enhancement" for females has been recalled because of the undeclared presence of tadalafil (Cialis, Eli Lilly), a drug used as a treatment for male erectile dysfunction, FDA announced. (Source: Drug Topics - Top News)

Lifestyle for Erectile Dysfunction: A Good Choice [Editor's Correspondence]

Archives of Internal Medicine — Mon, 13 Feb 2012 05:00:00 +0100

(Source: Archives of Internal Medicine)

Lifestyle for Erectile Dysfunction: A Good Choice--Reply [Editor's Correspondence]

Archives of Internal Medicine — Mon, 13 Feb 2012 05:00:00 +0100

(Source: Archives of Internal Medicine)

Regeneca, Inc. Issues A Voluntary Nationwide Recall Of A Specific Lot Of RegenArouse Because Of Potential Health Risks

Food and Drug Administration — Sun, 12 Feb 2012 00:14:00 +0100

Regeneca, Inc. announced today that it is conducting a voluntary nationwide recall of RegenArouse, Lot Number 130100, because FDA lab analysis has confirmed the presence of Tadalafil making these products unapproved new drugs. Tadalafil is an FDA-approved drug used as treatment for male Erectile Dysfunction (ED). The active drug ingredient is not listed on the label for these products. (Source: Food and Drug Administration)

Groundbreaking Medication in Men's Sexual Health to Revolutionize...

PRWeb: Medical Pharmaceuticals — Sat, 11 Feb 2012 10:55:14 +0100

More men suffer from premature ejaculation (PE) than any other sexual dysfunction, twice that of the more recognized erectile dysfunction. But there have been no safe and effective treatments for PE...(PRWeb February 10, 2012)Read the full story at http://www.prweb.com/releases/2012/2/prweb9181910.htm (Source: PRWeb: Medical Pharmaceuticals)

Regeneca, Inc. Issues a Voluntary Nationwide Recall of a Specific Lot of RegenArouse Because of Potential Health Risks

Medical News (via PRIMEZONE) — Sat, 11 Feb 2012 05:15:00 +0100

IRVINE, Calif., Feb. 11, 2012 (GLOBE NEWSWIRE) -- Regeneca, Inc. (Pink Sheets:RGNA) announced today that it is conducting a voluntary nationwide recall of RegenArouse, Lot Number 130100, because FDA lab analysis has confirmed the presence of Tadalafil making these products unapproved new drugs. Tadalafil is an FDA-approved drug used as treatment for male Erectile Dysfunction (ED). The active drug ingredient is not listed on the label for these products. (Source: Medical News (via PRIMEZONE))

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Erectile drugs might help premature ejaculation

Reuters: Health — Fri, 10 Feb 2012 18:51:10 +0100

NEW YORK (Reuters Health) - Most studies looking at whether erectile dysfunction drugs can help men overcome premature ejaculation problems agree that the pills make a difference, but much of the research is flawed, according to a new review of the evidence. (Source: Reuters: Health)

Obesity and Erectile Dysfunction of Young Men Conscripted into the Military in Taiwan

The Journal of Sexual Medicine — Thu, 09 Feb 2012 05:00:00 +0100

(Source: The Journal of Sexual Medicine)

Erectile dysfunction may be a warning

Health News - UPI.com — Thu, 09 Feb 2012 04:30:49 +0100

HOUSTON, Feb. 8 (UPI) -- Most men do not realize that erectile dysfunction is a warning sign of potential cardiovascular disease, a U.S. expert warns. (Source: Health News - UPI.com)

Erectile dysfunction may be a cardiovascular warning

Health News - UPI.com — Thu, 09 Feb 2012 04:30:49 +0100

HOUSTON, Feb. 8 (UPI) -- Most men do not realize that erectile dysfunction is a warning sign of potential cardiovascular disease, a U.S. expert warns. (Source: Health News - UPI.com)

Eczema tied to higher impotence risk: study

Reuters: Health — Thu, 09 Feb 2012 01:14:16 +0100

(Reuters) - Men who have the allergic skin condition eczema may have a higher risk of erectile dysfunction than other men, according to a Taiwanese study. (Source: Reuters: Health)

Eczema tied to higher impotence risk

Reuters: Health — Wed, 08 Feb 2012 17:20:01 +0100

NEW YORK (Reuters Health) - Men who have the allergic skin condition eczema may have a higher risk of erectile dysfunction than other men, a new study finds. (Source: Reuters: Health)

Is Inhibition of Phosphodiesterase Type-5 by Sildenafil a Promising Therapy for Volume Overload Heart Failure?

Circulation — Wed, 08 Feb 2012 05:00:00 +0100

Authors: Dai W, Kloner RA Abstract Phosphodiesterase type 5 (PDE5) is an enzyme that belongs to a large family of cyclic nucleotide PDEs that catalyze cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). cAMP and cGMP are two essential intracellular second messengers regulating many different cellular functions of living cells. PDE5 specifically breaks down the substrate cGMP. Inhibition of PDE5 increases intracellular cGMP levels by inhibiting its degradation. Sildenafil (Viagra) is a potent and selective inhibitor of cGMP-specific PDE5, and is the first oral treatment for males with erectile dysfunction, which was approved by Food and Drug Administration on March 27, 1998. Sildenafil binds to the catalytic site of PDE5 and inhibits the degradation of i...

Do Glaucoma, Erectile Dysfunction Have a Common Cause?Do Glaucoma, Erectile Dysfunction Have a Common Cause?

Medscape Today Headlines — Tue, 07 Feb 2012 21:20:39 +0100

Men with erectile dysfunction have 3 times the risk for open-angle glaucoma as men without erectile dysfunction. Medscape Medical News (Source: Medscape Today Headlines)

Occurrence of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome in patients with abdominal obesity. Where is a sufficient level of testosterone?

International Urology and Nephrology — Tue, 07 Feb 2012 18:02:37 +0100

Conclusion Patients over 40 years of age with AO and ED should also be examined for TDS and metabolic syndrome. In this group of patients we found that 113/167 patients (67.6%) had total TST below 14 nmol/l, and sufficient level of TST seems to be above this level. Content Type Journal ArticleCategory Urology – Original PaperPages 1-8DOI 10.1007/s11255-012-0132-1Authors Juraj Fillo, Department of Urology, Comenius University, Bratislava, SlovakiaJan Breza, Department of Urology, Comenius University, Bratislava, SlovakiaMichaela Levčíkova, Department of General Medicine, Comenius University, Bratislava, SlovakiaJan Luha, Department of General Medicine, Comenius University, Bratislava, SlovakiaAnna Vachulova, Department of General Medicine, Comenius Unive...

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Penile Doppler sonographic and clinical characteristics in Peyronie's disease and/or erectile dysfunction: an analysis of 1500 men with male sexual dysfunction

BJU International — Tue, 07 Feb 2012 05:00:00 +0100

CONCLUSIONS• Men with PD and ED had many similarities and differences on penile CDU.• Penile CDU continues to be an invaluable clinical tool in the management of men with male sexual dysfunction. (Source: BJU International)

A case‐control study on the association between chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction

BJU International — Tue, 07 Feb 2012 05:00:00 +0100

CONCLUSIONS• We conclude that there was an association between ED and having been previously diagnosed with CP/CPPS.• Urologists should be alert to the association between CP/CPPS and ED, and assess the erectile function of patients suffering from CP/CPPS. (Source: BJU International)

Yidiyin, a Chinese Herbal Decoction, Improves Erectile Dysfunction in Diabetic Patients and Rats through the NO-cGMP Pathway.

Bioscience, Biotechnology, and Biochemistry — Tue, 07 Feb 2012 05:00:00 +0100

Authors: Feng XT, Qin CB, Leng J, Tang QL, Shi H, Zhai LN, Li SL Abstract The nitric-oxide (NO)-cyclic-guanosine-monophosphate (cGMP) pathway plays a key role in penile erection. Erectile dysfunction (ED) is a complication in male diabetic patients that impacts their quality of 1ife. Recently, Yidiyin, a Chinese herbal decoction, is used to treat diabetic ED, but convincing evidence is lacking, and the potential mechanisms remain uncertain. In the study, diabetic ED patients had low scores on international index of erectile function-5 (IIEF-5), and administration of Yidiyin and hypoglycemic drugs for 16 weeks ameliorated patients' scores on IIEF-5 more than the hypoglycemic drug alone. Moreover, streptozotocin-induced diabetes severely impaired rats' erectile function and the activ...

Optical coherence tomography in tadalafil-associated retinal toxicity.

European Journal of Ophthalmology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions. Tadalafil use may be associated with reversible damage to the photoreceptors and corresponding visual symptoms. PMID: 22328305 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)

Diet supplements recalled on unlabeled drug worries

Reuters: Health — Mon, 06 Feb 2012 21:50:32 +0100

WASHINGTON (Reuters) - Healthy People Co is recalling 15 lots of seven different dietary supplements because they contain appetite suppressants or a drug for male erectile dysfunction, the Long Beach, California, company said. (Source: Reuters: Health)

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Treating Erectile Dysfunction and Central Neurological Diseases with Oral Phosphodiesterase Type 5 Inhibitors. Review of the Literature

The Journal of Sexual Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions. PDE5 represent first line ED therapy only for SCI patients, though treatment results through meta‐analysis were not possible. Encouraging results are reported for Parkinson's and MS patients. PDE5 use for other CND patients is limited for various reasons, such as ED and concomitant libido impairment caused by depression and/or sexual endocrinology dysfunctions, and because PDE5 may cause a worsening of neurological illness. Medical centers staffed by health professionals able to counsel patients on the possible use of PDE5 are needed. Lombardi G, Nelli F, Celso M, Mencarini M, and Del Popolo G. Treating erectile dysfunction and central neurological diseases with oral phosphodiesterase type 5 inhibitors. Review of the literature. J Sex Med **;**:**–**. (Source: The Journ...

The Association of eNOS G894T Polymorphism with Metabolic Syndrome and Erectile Dysfunction

The Journal of Sexual Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions. The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders. Lee Y‐C, Huang S‐P, Liu C‐C, Yang Y‐H, Yeh H‐C, Li W‐M, Wu W‐J, Wang C‐J, Juan Y‐S, Huang C‐N, Hour T‐C, Chang C‐F, and Huang C‐H. The Association of eNOS G894T polymorphism with metabolic syndrome and erectile dysfunction. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury

BJU International — Thu, 02 Feb 2012 05:00:00 +0100

CONCLUSIONS• The results obtained show that multiple biological processes are associated with injury and repair of the CN and provide a systematic genome‐wide screen for neurotrophic and/or inhibitory pathways of nerve regeneration.• These data identify the candidate genes that may be utilized in novel molecular‐based therapies for the preservation and protection of the CN during radical prostatectomy. (Source: BJU International)

Erectile dysfunction drug receives new indications.

The American Journal of Nursing — Wed, 01 Feb 2012 05:00:00 +0100

Authors: Aschenbrenner DS PMID: 22277864 [PubMed - in process] (Source: The American Journal of Nursing)

Reply by the Authors

Urology — Wed, 01 Feb 2012 05:00:00 +0100

Discussion, will actually address the concerns raised. First, the authors say that we “question some of the conclusions of a study performed by our research group on a cohort of European patients.” We did not question the veracity of their findings and acknowledged that there were differences in methodology and patient characteristics that could account for a different outcome in our North American patient cohort. We addressed in our paper the rationale for focusing only on erectile dysfunction, and the complete answer to the authors' question 2 can be found at length in the final paragraph of our discussion. (Source: Urology)

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The Cumulative Effects of Medication Use, Drug Use, and Smoking on Erectile Dysfunction Among Men Who Have Sex with Men

The Journal of Sexual Medicine — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion. Predictors of ED may differ by HIV status. Although smoking cessation and effective medication management may be important as possible treatment strategies for ED among all MSM, there may be a burden on sexual functioning produced by non‐HIV medications for HIV+ men. Hart TA, Moskowitz D, Cox C, Li X, Ostrow DG, Stall RD, Gorbach PM, and Plankey M. The cumulative effects of medication use, drug use, and smoking on erectile dysfunction among men who have sex with men. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Inflammatory Mechanisms and Oxidative Stress in Peyronie's Disease: Therapeutic "Rationale" and Related Emerging Treatment Strategies.

Inflammation and Allergy Drug Targets — Wed, 01 Feb 2012 05:00:00 +0100

Inflammatory Mechanisms and Oxidative Stress in Peyronie's Disease: Therapeutic "Rationale" and Related Emerging Treatment Strategies. Inflamm Allergy Drug Targets. 2012 Feb 1;11(1):48-57 Authors: Paulis G, Brancato T Abstract Peyronie's disease (PD) is a connective tissue disorder characterized by a fibrous plaque involving the tunica albuginea of the penis. The inelastic fibrous plaque leads to a penile curvature. Several Authors have suggested an immunological genesis of this disease, others have linked PD with Dupuytren's contracture. Signs of this disease are curvature, penile pain, penile deformity, difficulty with coitus, shortening, hinging, narrowing and erectile dysfunction. The natural history of PD and the clinical course can develop from spontaneous resolution ...

Androgen deprivation therapy-associated vasomotor symptoms.

Asian Journal of Andrology — Mon, 30 Jan 2012 05:00:00 +0100

This article reviews current options for the treatment of hot flashes in patients taking ADT.Asian Journal of Andrology advance online publication, 30 January 2012; doi:10.1038/aja.2011.101. PMID: 22286861 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)

Conservative management for postprostatectomy urinary incontinence.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: The value of the various approaches to conservative management of postprostatectomy incontinence after radical prostatectomy remains uncertain. It seems unlikely that men benefit from one-to-one pelvic floor muscle training therapy after transurethral resection of the prostate (TURP). Long-term incontinence may be managed by external penile clamp, but there are safety problems. PMID: 22258946 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Cardio‐Selective Beta‐Blocker: Pharmacological Evidence and Their Influence on Exercise Capacity

Cardiovascular Therapeutics — Thu, 26 Jan 2012 05:00:00 +0100

SUMMARY For the past 40 years, beta‐blockers have been widely used in cardiovascular medicine, reducing morbidity as well as mortality. Beta‐blockers are currently used in a number of cardiovascular conditions such as systolic heart failure, postmyocardial infarction, and in prevention and treatment of arrhythmias. They are not recommended as the first line antihypertensive therapy, particularly in the elderly, unless there are specific indications. Despite the benefits of beta‐blockers, tolerability concerns in patients with co‐morbidities have limited their use. Some of these problems were overcome with the discovery of cardioselective beta‐blockers. The third generation beta‐blockers have additional properties of vasodilatation and advantages in terms of minimizing the ad...

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Despite Some Comprehension Problems the International Index of Erectile Function Is a Reliable Questionnaire in Erectile Dysfunction

Urologia Internationalis : Last 20 articles — Tue, 24 Jan 2012 23:00:00 +0100

Urol Int (DOI:10.1159/000335432) (Source: Urologia Internationalis : Last 20 articles)

Erectile function restored with stem cells

New Scientist - Health — Tue, 24 Jan 2012 17:27:55 +0100

Pig intestine coated with stem cells has been used to treat erectile dysfunction in rats with the hope that a similar therapy can be used in humans (Source: New Scientist - Health)

Pursuit of sexual function post-radical prostatectomy.

Canadian Urological Association Journal — Tue, 24 Jan 2012 05:00:00 +0100

CONCLUSION: Sexual frequency peaked in younger patients who were 3 years or more from surgery. Of note, 46% of men either declined the offer of ED therapy or got the prescription and never used it. Only 34% of men had used their ED prescription in the last 4 weeks. Urologists frequently find that patients behave differently postoperatively, with less interest in sexual activity. Interestingly, we found that 50% of our patients classified their sexual function, as at most a small problem. PMID: 22277629 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)

HSE spend on Viagra not justified, forum hears

The Irish Times - Health — Tue, 24 Jan 2012 00:19:24 +0100

HEALTH BRIEFING:A SENIOR member of the HSE West Forum yesterday stated that the State spend on Viagra and other erectile dysfunction drugs “can no longer be justified”. (Source: The Irish Times - Health)

Link Between Treatment of Erectile Dysfunction and Depression

About.com Mental Health — Sun, 22 Jan 2012 05:00:00 +0100

Successful treatment of erectile dysfunction in depressed men can lead to marked improvement in depression. (Am. J.of Psychiatry, Oct-2001) (Source: About.com Mental Health)

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Erectile dysfunction, edible microchips, headphone dangers: HealthPop Video

Health News: CBSNews.com — Fri, 20 Jan 2012 20:24:29 +0100

Men who don't get enough alone time with their male friends are more prone to erectile dysfunction, according to a new study. Hear more from CBSNews.com's Nick Dietz in HealthPop's latest video (Source: Health News: CBSNews.com)

Sex Is O.K. For Heart Attack Patients

Health News from Medical News Today — Fri, 20 Jan 2012 19:00:00 +0100

A scientific statement from The American Heart Association clarifies that sexual activity for those with heart conditions is ok. They caution that women should be counseled on use of contraceptive methods and possible adverse effects of pregnancy, while men should be wary of certain erectile dysfunction medications that are unsafe for all cardiovascular diseases. The statement was published online 19th Jan... (Source: Health News from Medical News Today)

Erectile Dysfunction and Its Severity Are Related to the Number of Cardiovascular Risk Factors.

Actas Urologicas Espanolas — Fri, 20 Jan 2012 05:00:00 +0100

CONCLUSIONS: The presence and severity of ED correlate with the presence of HT, DM, Dyslipidemia and the number of DVRF. PMID: 22266257 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

Video: HealthPop: Guys' night out and erectile dysfunction

Health News: CBSNews.com — Thu, 19 Jan 2012 23:26:03 +0100

Men who don't get enough alone time with their male friends are more prone to erectile dysfunction; Also, an edible microchip that makes sure you're taking your meds; Plus, wearing headphones while walking around town may pose a safety risk; And, a nose job can make people appear about one-and-a-half-years younger. (Source: Health News: CBSNews.com)

Sexual function with localized prostate cancer: active surveillance vs radical therapy

BJU International — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSIONS• Men with localized PCa on AS were more often sexually active than similar men who received radical therapy, especially RP. If not sexually active, this was less often attributable to erectile dysfunction for those on AS. If sexually active, this was less often associated with problems getting or keeping an erection for those on AS.• The study was non‐randomized; the latest advances in RP and RT might impact results. (Source: BJU International)

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Inhibition of sympathetic neuroeffector transmission in human corpus cavernosum

BJU International — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSIONS• These data suggest that neurogenic contractions are mediated by an increase in Ca(2+) influx via L‐type voltage‐gated Ca(2+) channels and that an increase in Ca(2+) sensitivity is mediated by the ROCK pathway and the PDE5 enzyme system as well as by the inhibitory NO/sGC/cGMP pathway.• The neurogenic contractile response in HCC is mediated by several intracellular pathways, including adrenergic receptors, Ca(2+) entry, Ca(2+) sensitization and activation of the PDE5 enzyme. The Rho‐kinase (ROCK) inhibitor fasudil, L‐type Ca(2+) channel antagonist isradipine, and PDE5 inhibitor sildenafil, as well as a NO‐independent stimulator of sGC, had similar inhibitory effects, suggesting parallel mechanisms in the HCC. (Source: BJU International)

Re: Combined Tadalafil and α-Blocker Therapy for Benign Prostatic Hyperplasia in Patients With Erectile Dysfunction: A Multicenter, Prospective Study

The Journal of Urology — Thu, 19 Jan 2012 05:00:00 +0100

J. Y. Lee, S. Y. Park, T. Y. Jeong, H. S. Moon, Y. T. Kim, T. K. Yoo, H. Y. Choi, H. Y. Park and S. W. Lee J Androl 2011; Epub ahead of print. (Source: The Journal of Urology)

Re: Erectile Dysfunction can Improve the Effectiveness of the Current Guidelines for the Screening for Asymptomatic Coronary Artery Disease in Diabetes

The Journal of Urology — Thu, 19 Jan 2012 05:00:00 +0100

C. Gazzaruso, A. Coppola, T. Montalcini, C. Valenti, A. Garzaniti, G. Pelissero, F. Salvucci, P. Gallotti, A. Pujia, C. Falcone, S. B. Solerte and A. Giustina Internal Medicine, Diabetes, Endocrine-Metabolic Diseases and Cardiovascular Prevention Unit, Centre for Applied Clinical Research, Clinical Institute Beato Matteo, Vigevano, Pavia, Italy (Source: The Journal of Urology)

Erectile dysfunction in testicular cancer patients treated with chemotherapy

Andrologia — Wed, 18 Jan 2012 13:50:23 +0100

SummaryInformation on male potency in testicular cancer (TC) patients treated with chemotherapy is insufficient. We aimed to assess the levels of depression and anxiety symptoms, sexual function and gonodotrophins. Participants (n = 27) were identified and recruited from the genitourinary services of two medical centres, one in Inonu University and the other in the Firat University. All patients are TC patients treated with chemotherapy after unilateral orchiectomy. Participants completed follow‐up assessments after the completion of the chemotherapy regimen. Serum luteinising hormone, follicle‐stimulating hormone and testosterone levels were determined after blood samples had been taken in the morning after an overnight fast. International Index of Erectile Function (IIEF‐15) was ...

Effect of atorvastatin on erectile functions in comparison with regular tadalafil use. A prospective single-blind study

International Urology and Nephrology — Wed, 18 Jan 2012 06:59:32 +0100

Conclusion Tadalafil 20 mg three times/week shows better results than 10 mg atorvastatin daily. Atorvastatin alone seems to improve EF compared to not using any medication, and this significance is more prominent in patients with supranormal serum lipid levels. Further studies with subgroups of different serum lipid levels should be conducted. Content Type Journal ArticleCategory Urology – Original PaperPages 1-5DOI 10.1007/s11255-012-0126-zAuthors Mehmet İlker Gokce, Department of Urology, Ankara University School of Medicine, Adnan Saygun Caddesi, Altındağ, Ankara, TurkeyÖmer Gülpınar, Department of Urology, Ankara University School of Medicine, Adnan Saygun Caddesi, Altındağ, Ankara, TurkeyErdem Öztürk, Department of Urology, Ankara Universi...

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Vulnerability to AIDS among the elderly in an urban center in central Brazil

Clinics — Wed, 18 Jan 2012 00:35:44 +0100

CONCLUSION: Unprotected sex was the primary factor accounting for vulnerability to AIDS among the elderly. (Source: Clinics)

Vivus Avanafil shows efficacy against erectile dysfunction

Drug Development Technology — Wed, 18 Jan 2012 00:00:00 +0100

Vivus has reported the results from its Phase III Revive study investigating the safety and efficacy of an investigational drug Avanafil, used for the treatment of erectile dysfunction (ED). (Source: Drug Development Technology)

Why Do I Find Porn More Exciting Than A Partner?

Psychology Today Sex Center — Tue, 17 Jan 2012 19:26:49 +0100

"In the past I noticed beauty, but never FELT a DESIRE to be with a girl. I directed all my sex drive toward porn. I could never think about myself having real sex with a real girl. Now, I feel like sex is the most natural thing to do. 'Hell yeah it's possible for me to have sex. Hell yeah there's a lot of girls out there wanting to have it with me!' It's awesome!"read more (Source: Psychology Today Sex Center)

Apricus Biosciences Announces Allowance of Israeli Patent, Expanding Its Patent Portfolio for the Topical Treatment of Premature Ejaculation

Medical News (via PRIMEZONE) — Tue, 17 Jan 2012 15:03:00 +0100

SAN DIEGO, Jan. 17, 2012 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. ("Apricus Bio" or the "Company") (Nasdaq:APRI) (http://www.apricusbio.com) announced today that the Israeli Patent Office recently issued a Notice of Allowance to grant a patent for the Company's development of a topical cream utilizing vasoactive prostaglandin E to treat premature ejaculation ("PE"). When issued, the patent, entitled, "Compositions and Methods for the Treatment of Premature Ejaculation," will provide Israeli patent protection until March 2024. It is one in a series of issued patents and pending applications that Apricus Bio owns in the male sexual dysfunction field utilizing its proprietary NexACT(r) technology, which includes its Vitaros(r) product to treat erectile dysfunction ("ED"), among others in...

Problems in the bedroom? Scientists say it could be because your partner gets on too well with your friends

the Mail online | Health — Tue, 17 Jan 2012 11:16:30 +0100

A study by Cornell University found that older men who do all their socialising alongside their other halves are more likely to suffer from erectile dysfunction. (Source: the Mail online | Health)

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Laparoscopic radical cystectomy for bladder cancer with prostatic and neurovascular sparing: initial experience

International Urology and Nephrology — Tue, 17 Jan 2012 07:17:24 +0100

Conclusion The laparoscopic radical cystectomy with a partial prostate preservation offers the advantages of a high continence, minimal impairment of erectile function, and low recurrence rate. Content Type Journal ArticleCategory Urology – Original PaperPages 1-6DOI 10.1007/s11255-011-0121-9Authors Xin Gou, Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016 ChinaMing Wang, Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016 ChinaWei-yang He, Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016 ChinaCao-Dong Liu, Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016 Chin...

Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger

Cancer — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS:Young men undergoing proton therapy for treatment of prostate cancer have excellent outcomes with respect to erectile dysfunction, urinary incontinence, and other health‐related quality of life parameters during the first 2 years after treatment. Longer follow‐up is needed to confirm these findings. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer)

Andropausal symptoms in men with Type 2 diabetes

Diabetic Medicine — Mon, 16 Jan 2012 05:00:00 +0100

Conclusions Our data demonstrated that men with Type 2 diabetes have higher prevalence of andropausal symptoms, especially those with diabetic complications.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

Does Current Scientific and Clinical Evidence Support the Use of Phosphodiesterase Type 5 Inhibitors for the Treatment of Premature Ejaculation? A Systematic Review and Meta‐analysis

The Journal of Sexual Medicine — Mon, 16 Jan 2012 05:00:00 +0100

Conclusion. There is inadequate, partial basic, and clinical evidence to support the use of PDE5 for the treatment of PE. Asimakopoulos AD, Miano R, Agrò EF, Vespasiani G, and Spera E. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? A systematic review and meta‐analysis. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

FDA approves drugs for BPH, AF

Modern Medicine — Sun, 15 Jan 2012 05:00:00 +0100

FDA has approved tadalafil to treat benign prostatic hyperplasia in patients with or without erectile dysfunction and rivaroxaban to reduce the risk of stroke in patients with nonvalvular atrial fibrillation. (Source: Modern Medicine)

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Central obesity as measured by waist circumference is predictive of severity of lower urinary tract symptoms

BJU International — Sun, 15 Jan 2012 00:07:06 +0100

CONCLUSIONS• Increased WC is associated with worsened voiding.• There was a significantly increased prevalence of components of the metabolic syndrome in patients with higher WC.• Obese men, in particular those with other features of the metabolic syndrome, are at increased risk of male pelvic dysfunction and can be easily recognized by measurement of WC. (Source: BJU International)

Acceptability and Preliminary Feasibility of an Internet/CD-ROM-Based Education and Decision Program for Early-Stage Prostate Cancer Patients: Randomized Pilot Study

Journal of Medical Internet Research — Fri, 13 Jan 2012 05:00:00 +0100

Conclusions: This pilot study confirms that the implementation of PIES within a clinical practice is feasible and acceptable to patients with a recent diagnosis of prostate cancer. PIES improved key decision-making process variables and reduced the emotional impact of a difficult medical decision. (Source: Journal of Medical Internet Research)

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Erectile Function Outcome after Bilateral Nerve Sparing Radical Prostatectomy: Which Patients May Be Left Untreated?

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. Overall, the rate of EF postoperative recovery in patients left untreated after surgery is modest (35.8%). Although younger patients with a good preoperative EF may experience good EF recovery rates even without any treatment, use of PDE5 after surgery further improved their functional outcomes. Therefore, a therapy for ED should be offered to all patients treated with BNSRP. Gallina A, Ferrari M, Suardi N, Capitanio U, Abdollah F, Tutolo M, Bianchi M, Saccà A, Salonia A, Rigatti P, Montorsi F, and Briganti A. Erectile function outcome after bilateral nerve sparing radical prostatectomy: Which patients may be left untreated? J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

A Population‐Based Study on the Association between Gastric Ulcers and Erectile Dysfunction in Taiwan

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusion. Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED. Keller JJ, Lin H‐Yu, Chung S‐D, and Lin H‐C. A population‐based study on the association between gastric ulcers and erectile dysfunction in Taiwan. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Characterization of Hypoactive Sexual Desire Disorder (HSDD) in Men

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. Based on a brief structured interview, diagnosis according to DSM‐IV‐TR criteria for HSDD identified a population of men comparable with men without HSDD in age, serum testosterone, concomitant illness and medication use but distinct in their experience of sexual desire and distress associated with low desire. These controlled data characterize HSDD in men as a distinct sexual dysfunction. DeRogatis L, Rosen RC, Goldstein I, Werneburg B, Kempthorne‐Rawson J, and Sand M. Characterization of Hypoactive Sexual Desire Disorder (HSDD) in men. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Penile Arterial Waveform Analyzing System for Early Identification of Young Adults with High Risk of Erectile Dysfunction

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. Not only could the penile waveform analyzing system assess penile endothelial function in young adults, but the results also showed significant associations with their serum testosterone levels and metabolic parameters. The findings suggest that PAWA ratio may serve as an indicator for early identification and treatment of young adults at risk of erectile dysfunction. Wu H‐T, Lee C‐H, Chen C‐J, and Sun C‐K. Penile arterial waveform analyzing system for early identification of young adults with high risk of erectile dysfunction. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Evaluation of Endothelial Function with Brachial Artery Ultrasound in Men with or without Erectile Dysfunction and Classified as Intermediate Risk According to the Framingham Score

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. Men without established atherosclerotic disease presenting with ED demonstrated a worse endothelial function. Averbeck MA, Colares C, de Lira GHS, Selbach T, and Rhoden EL. Evaluation of endothelial function with brachial artery ultrasound in men with or without erectile dysfunction and classified as intermediate risk according to the Framingham score. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

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Association of Erectile Dysfunction with Atopic Dermatitis: A Population‐Based Case‐Control Study

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. There was an association between ED and prior AD. We suggest that clinicians should be more attentive to sexual complaints from patients with AD. Chung S‐D, Keller JJ, and Lin H‐C. Association of erectile dysfunction with atopic dermatitis: A population‐based case‐control study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Risk of Erectile Dysfunction and Retrograde Ejaculation Associated with Thulium Laser Vaporesection of the Prostate for Bladder Outflow Obstruction: A Retrospective Study

Urologia Internationalis : Last 20 articles — Mon, 09 Jan 2012 23:00:00 +0100

Urol Int (DOI:10.1159/000333046) (Source: Urologia Internationalis : Last 20 articles)

The Use of Sudafed for Priapism in Pediatric Patients With Sickle Cell Disease

Journal of Pediatric Nursing — Fri, 06 Jan 2012 02:27:01 +0100

ACCORDING TO , the estimated incidence of priapism related to sickle cell disease (SCD) is 35% to 89%. Medical management is required for these patients to minimize ischemia caused by low-flow priapism and is considered a urological emergency. Without immediate intervention, or a regimen for reoccurrence, long-term erectile dysfunction can occur, which contributes to the health challenges and difficulties in the psychosocial and mental well-being of men with SCD. Therapeutic management of priapism includes medications, such as pseudoephedrine, to diminish the vasoocclusive crisis associated with this issue in patients with SCD. (Source: Journal of Pediatric Nursing)

Can serum asymmetric dimethylarginine become a marker of vasculogenic erectile dysfunction?

Indian Journal of Urology — Wed, 04 Jan 2012 05:00:00 +0100

Rohit KathpaliaIndian Journal of Urology 2011 27(4):566-567 (Source: Indian Journal of Urology)

Attitudes and experiences: qualitative perspectives on erectile dysfunction from the female partner

Journal of Health Psychology — Tue, 03 Jan 2012 05:00:00 +0100

This study explored the woman’s experience of her partner’s erectile dysfunction (ED) focusing particularly on sexual experiences, relationship satisfaction, and communication. One hundred women completed a semi-structured interview, providing information about how ED impacted her relationship with her partner. For some women, there was a sense of hopelessness and frustration surrounding their sex lives, while for others, her partner’s ED had led to efforts towards increasing non-physical intimacy and sexual communication. These findings demonstrate the importance of the relationship, including communication between the partners, in a women’s experience of her partners’ ED. (Source: Journal of Health Psychology)

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Albuminuria is an Independent Risk Factor of Erectile Dysfunction in Men with Type 2 Diabetes

The Journal of Sexual Medicine — Tue, 03 Jan 2012 05:00:00 +0100

Conclusion. Albuminuria is an important independent risk factor of ED in men with diabetes after adjustment of age and diabetes mellitus duration. Identification and control of albuminuria and other associated risk factors might play a role in the prevention or reversal of ED. Chuang Y‐C, Chung M‐S, Wang P‐W, Lee W‐C, Chen C‐D, Chang H‐W, Yang KD, Chancellor MB, and Liu RT. Albuminuria is an independent risk factor of erectile dysfunction in men with type 2 diabetes. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Erectile Dysfunction and Premature Ejaculation in Men Who Have Sex with Men

The Journal of Sexual Medicine — Tue, 03 Jan 2012 05:00:00 +0100

Conclusions. Risk factors for sexual problems in MSM are similar to what has been observed in quantitative studies of non‐MSM males. Urinary symptoms are associated with poorer sexual function in MSM. Shindel AW, Vittinghoff E, and Breyer BN. Erectile dysfunction and premature ejaculation in men who have sex with men. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

The Intra‐ and Inter‐Personal Dynamics Associated with Consuming Sensitive Products: Understanding the Consumption of Erectile Function Aids Using Dimensional Qualitative Research

Psychology and Marketing — Sun, 01 Jan 2012 05:00:00 +0100

This study utilizes a dimensional qualitative research (DQR) approach to examine what men think, feel, and experience as they consider integrating erectile function (EF) aids into their sexual relationships. The findings suggest that the process of accepting changes in sexual functioning and consuming EF aids frequently moves beyond intrapersonal issues to encompass spouse/partner relationships. The insights gleaned from this study have implications not only for the marketing of EF aids but also for healthcare professionals assisting men in the treatment of their symptoms. Finally, the study findings expand current marketing applications of the DQR framework by demonstrating the value of second‐order modality analysis. (Source: Psychology and Marketing)

Recreational urethral sounding is associated with high risk sexual behaviour and sexually transmitted infections

BJU International — Sun, 01 Jan 2012 05:00:00 +0100

CONCLUSIONS• Urethral sounding is a sexual practice that is associated with higher risk sexual behaviour and carries the potential for morbidity.• Research on means for risk reduction for men who choose to engage in recreational sounding requires further study. (Source: BJU International)

Human Telomerase Reverse Transcriptase Transfection Reduces Apoptosis in Human Penile Smooth Muscle Cells and Slows Down Cellular Aging

The Journal of Sexual Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Conclusion. In this study, for the first time, the hTERT gene was transfected into human penile smooth muscle cells, and the gene increased telomerase activity in cells, reduced cell apoptosis, and slowed down cell aging. We believe that this finding is of potential clinical value in the prevention and treatment of organic ED. Wu XJ, Song B, Zhang J, Li L, Ji H, Lu G, Chen Z, Li W, and Zhou Z. Human telomerase reverse transcriptase transfection reduces apoptosis in human penile smooth muscle cells and slows down cellular aging. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

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How to Evaluate the Efficacy of the Phosphodiesterase Type 5 Inhibitors

The Journal of Sexual Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions. Comparison between PDE5Is using both subjective and objective parameters will permit to individuate, on the basis of the evidence, the subset of couples where one drug, or one dose, or dose regimen, is to be considered of first choice. Jannini EA, DeRogatis LR, Chung E, and Brock GB. How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors. J Sex Med 2012;9:26–33. (Source: The Journal of Sexual Medicine)

Couples' Reasons for Adherence to, or Discontinuation of, PDE Type 5 Inhibitors for Men with Erectile Dysfunction at 12 to 24‐Month Follow‐Up after a 6‐Month Free Trial

The Journal of Sexual Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions. This is the first study to ask couples why they decided to continue or stop using PDE5 when followed up. Female partners provided a different perspective on “partner issues” often cited as reasons for discontinuing PDE5 use. It was also clear that discontinuation did not mean couples were no longer sexually active. Conaglen HM and Conaglen JV. Couples' reasons for adherence to, or discontinuation of, PDE type 5 inhibitors for men with erectile dysfunction at 12 to 24‐month follow‐up after a 6‐month free trial. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

A Randomized, Double‐Blind, Placebo‐Controlled Evaluation of the Safety and Efficacy of Avanafil in Subjects with Erectile Dysfunction

The Journal of Sexual Medicine — Sun, 01 Jan 2012 05:00:00 +0100

Conclusion. Following 12 weeks of avanafil treatment without food or alcohol restrictions, significant improvements in sexual function were observed with all 3 doses of avanafil compared with placebo. Successful intercourse was observed as early as 15 minutes and >6 hours after dosing in some subjects. Avanafil was generally well tolerated for the treatment of ED. Goldstein I, McCullough AR, Jones LA, Hellstrom WJ, Bowden CH, DiDonato K, Trask B, and Day WW. A randomized, double‐blind, placebo‐controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Erectile dysfunction: a weighty issue?

Practical Diabetes International — Sun, 01 Jan 2012 05:00:00 +0100

In conclusion, the majority of recent studies show that weight loss can improve erectile function in obese men, though the beneficial effect is less profound in diabetic men. Copyright © 2012 John Wiley & Sons. (Source: Practical Diabetes International)

OIG Details Health Investigation Plan for 2012

MedPage Today Public Health — Thu, 29 Dec 2011 20:00:00 +0100

WASHINGTON (MedPage Today) -- Doctors opting out of Medicare, fraudulent Medicare claims, and erroneous Medicare payments for erectile dysfunction drugs are just a few of the issues the Department of Health and Human Services' Office of Inspector General will be looking into in 2012. (Source: MedPage Today Public Health)

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Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED.

Atherosclerosis — Thu, 29 Dec 2011 05:00:00 +0100

Authors: Williams JK, Andersson KE, Christ G Abstract Erectile dysfunction (ED) is a prevalent medical condition affecting 18 million men and their sexual partners in the United States alone. In the majority of patients, ED is related to alterations in the flow of blood to or from the penis. Undeniably, significant progress has been made in understanding the multifactorial mechanisms that modulate erectile capacity and predispose one to ED, and this, in turn, has led to the availability of more effective treatment options. Nonetheless, all current therapies have untoward side effects, and moreover, there are still no satisfactory treatments for many patients with ED. Further enhancements in the treatment of ED would logically result from both early intervention and more detailed me...

Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats

International Journal of Impotence Research — Thu, 29 Dec 2011 05:00:00 +0100

Authors: N Gurbuz, G Sagdic, A Sanli, A Ciftcioglu, I Bassorgun, A Baykal & M F Usta (Source: International Journal of Impotence Research)

Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED

International Journal of Impotence Research — Thu, 29 Dec 2011 05:00:00 +0100

Authors: J K Williams, K-E Andersson & G Christ (Source: International Journal of Impotence Research)

Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?

Asian Journal of Andrology — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Gontero P, Oderda M, Filippini C, Fontana F, Lazzarich E, Stratta P, Turello E, Tizzani A, Frea B Abstract Reduced cavernosal arterial inflow has been hypothesized to be the likely cause of erectile dysfunction after kidney transplants in recipients revascularized through end-to-end anastomosis to the internal iliac artery, suggesting that end-to-side anastomosis at the external iliac artery is preferable. The aim of this study was to prospectively evaluate the effect of the use of the external iliac artery on erectile function, hormone profiles and penile blood flow by evaluating changes in penile colour Doppler ultrasound parameters in a consecutive series of 22 recipients before and after end-to-side external iliac artery transplantation. The mean International Index of...

Sexuality and body image in long-term survivors of testicular cancer

European Journal of Cancer — Mon, 26 Dec 2011 05:00:00 +0100

Conclusion: Apart from RPLND, which was associated with ejaculatory dysfunction, treatment strategies for testicular cancer appeared not to influence sexual dysfunction. The level of erectile dysfunction seen in this sample of TCSs seemed to be higher than the level observed in the general male population and high levels of erectile dysfunction were associated with negative changes in body image. The results suggest that changes in body image are of importance when explaining the variation in sexual dysfunctions, but further prospective studies are needed to clarify this issue. (Source: European Journal of Cancer)

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Vasogenic erectile dysfunction Topiramate-induced

Clinical Neurology and Neurosurgery — Fri, 23 Dec 2011 21:05:35 +0100

We described two epileptic male patients which experienced erectile dysfunction during Topiramate treatment. Serum sexual hormones were tested during treatment and at several time intervals following drug discontinuation. Topiramate did not seem to affect plasma levels of total, free and bioavailable testosterone and sex hormone-binding globulin. Since Topiramate erectile dysfunctions could not be related to changes in reproductive hormones levels, a vasogenic mechanism must be considered. (Source: Clinical Neurology and Neurosurgery)

Efficacy of alfuzosin and sildenafil combination in male patients with lower urinary tract symptoms

Andrologia — Fri, 23 Dec 2011 05:00:00 +0100

SummaryLower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are frequently encountered in ageing males. We compared the efficacy of alfuzosin 10 mg alone or in combination with sildenafil 50 mg in the treatment of LUTS due to benign prostatic hyperplasia. One hundred male patients older than 45 years were randomized to two groups containing 50 patients each; one group receiving alfuzosin 10 mg and the other group alfuzosin 10 mg combined with sildenafil 50 mg. International Prostate Symptom Score (IPSS), quality of life (QoL), maximum flow rate (Qmax), prostate volume and post‐void residual urine were evaluated. The mean age was 60.2 ± 17.8. Mean data of evaluated parameters in both groups at the end of 3rd month compared with baseline values are given respective or...

A Case of Recurrent Transient Monocular Visual Loss after Receiving Sildenafil

Gastroenterology Research and Practice — Thu, 22 Dec 2011 09:37:26 +0100

A 53-year-old man was attended to the Clinic Ophthalmic Center, Mansoura University, Egypt, with recurrent transient monocular visual loss after receiving sildenafil citrate (Viagra) for erectile dysfunction. Examination for possible risk factors revealed mild hypercholesterolemia. Family history showed that his father had suffered from bilateral nonarteritic anterior ischemic optic neuropathy (NAION). Physicians might look for arteriosclerotic risk factors and family history of NAION among predisposing risk factors before prescribing sildenafil erectile dysfunction drugs. (Source: Gastroenterology Research and Practice)

Comparative effectiveness of cryotherapy vs brachytherapy for localised prostate cancer

BJU International — Thu, 22 Dec 2011 05:00:00 +0100

CONCLUSIONS• Although less costly, cryotherapy was associated with more urinary and ED complications and greater need for salvage ADT.• Conversely, cryotherapy was associated with fewer bowel complications. Patients and providers alike should consider these population‐based outcomes when discussing therapeutic options for localised prostate cancer. (Source: BJU International)

Men's Health: Sexual Dysfunction, Physical, and Psychological Health—Is There a Link?

The Journal of Sexual Medicine — Wed, 21 Dec 2011 05:00:00 +0100

Conclusion. The association between men's sexual dysfunction and physical and psychological health is real and proven. Therefore, it should not be taken lightly but instead treated as a life‐threatening medical problem. Tan HM, Tong SF, and Ho CCK. Men's health: Sexual dysfunction, physical, and psychological health—Is there a link? J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

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Choosing the Best Candidates for Penile Rehabilitation after Bilateral Nerve‐Sparing Radical Prostatectomy

The Journal of Sexual Medicine — Wed, 21 Dec 2011 05:00:00 +0100

Conclusion. The ideal candidates for penile rehabilitation after surgery are patients at intermediate risk of ED. Briganti A, Di Trapani E, Abdollah F, Gallina A, Suardi N, Capitanio U, Tutolo M, Passoni N, Salonia A, DiGirolamo V, Colombo R, Guazzoni G, Rigatti P, and Montorsi F. Choosing the best candidates for penile rehabilitation after bilateral nerve‐sparing radical prostatectomy. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Asthma and Risk of Erectile Dysfunction in Taiwan—Patient‐Based or Population‐Based?

The Journal of Sexual Medicine — Wed, 21 Dec 2011 05:00:00 +0100

(Source: The Journal of Sexual Medicine)

Are Urology Residents Ready to Treat Premature Ejaculation After Their Training?

The Journal of Sexual Medicine — Wed, 21 Dec 2011 05:00:00 +0100

Conclusions. The majority of URs follow the established guidelines for diagnosis of PE, but not for treatment. The URs have an insufficient medical education in sexual medicine. Luján S, García‐Fadrique G, Morales G, Morera J, Broseta E, and Jiménez‐Cruz JF. Are urology residents ready to treat premature ejaculation after their training? J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Association between Preoperative Erectile Dysfunction and Prostate Cancer Features—An Analysis from the Duke Prostate Center Database

The Journal of Sexual Medicine — Wed, 21 Dec 2011 05:00:00 +0100

Conclusions. These results suggest that the likelihood for adverse pathological outcomes as well as BCR following prostatectomy is higher among men with preoperative ED, though these results require validation in larger datasets. The present study indicates that preoperative ED might be a surrogate for adverse prostate cancer outcomes following RP. Kimura M, Bañez LL, Gerber L, Qi J, Tsivian M, Freedland SJ, Satoh T, Polascik TJ, Baba S, and Moul JW. Association between preoperative erectile dysfunction and prostate cancer features—An analysis from the Duke Prostate Center Database. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Clinical and radiological findings in macroprolactinemia

Endocrine — Tue, 20 Dec 2011 16:46:56 +0100

Abstract Hyperprolactinemia is the most common abnormality of the hypothalamic–pituitary axis. The aim of this study was to investigate the clinical and radiological features of patients with macroprolactinemia. The study population consisted of patients with elevated serum prolactin (PRL) concentrations who presented to our Endocrinology outpatient clinic. Detection of macroprolactin (macroPRL) was performed using the polyethylene glycol precipitation method. Patients in which macroPRL made up more than 60% of total PRL levels were stratified into the macroPRL group, while the remaining patients were placed in the monomeric prolactin (monoPRL) group. A total of 337 patients were enrolled with a mean age of 33.8 ± 10.8 (16–66) years and a male/female ratio o...

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Man Gets 13 Months in Fake-pill Ring

Drugs.com - Pharma News — Tue, 20 Dec 2011 11:12:47 +0100

From Houston Chronicle (TX) (December 20, 2011) Dec. 20--The leader of a Houston-based ring that illegally imported thousands of counterfeit Viagra and Cialis pills from China and sold the erectile-dysfunction remedies as the real deal... (Source: Drugs.com - Pharma News)

Silodosin and its potential for treating premature ejaculation: A preliminary report

International Journal of Urology — Tue, 20 Dec 2011 05:00:00 +0100

AbstractPremature ejaculation is a common sexual problem, as is erectile dysfunction. We evaluated silodosin, a highly selective α1A‐adrenoceptor antagonist, as a new treatment option for premature ejaculation. α1‐Adrenoceptor antagonists are widely used for lower urinary tract symptoms, and clinical studies on silodosin have shown excellent clinical efficacy for lower urinary tract symptoms. However, compared with other α1‐adrenoceptor antagonists, silodosin appeared to suppress ejaculation in a relatively higher percent of trial participants. This suppression of ejaculation by silodosin suggested its potential for treating premature ejaculation. Consequently, we evaluated the feasibility of off‐label silodosin as a new treatment option for premature ejaculation. Eight patients...

Cancer of the prostate gland

Medicine — Tue, 20 Dec 2011 02:10:11 +0100

Abstract: Prostate cancer constitutes a major health problem. It is estimated that the lifetime risk of western men having prostate cancer is about 30%, with the risk of dying from the cancer being 3%. Increasing age is the strongest pre-determinant for the development of prostate cancer. Virtually all cancers are adenocarcinomas, the grade being indicated by the Gleason score. Often, there are no presenting symptoms. Investigations such as serum prostate-specific antigen (PSA), digital rectal examination and biopsies via a transrectal ultrasound probe are required for diagnosis. Staging, if required, consists of magnetic resonance imaging or computed tomography for locally advanced disease and/or a bone scan for detection of bony metastases. Management depends largely on the stage of the ...

Adjuvant radiotherapy following radical prostatectomy for prostate cancer.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: Adjuvant RT after RP improves overall survival and reduces the rate of distant metastases, but these effects are only evident with longer follow up. At 5 and 10 years it improves local control and reduces the risk of biochemical failure, although the latter is not a clinical endpoint. Moderate or severe acute and late toxicity is minimal. There is an increased risk of urinary stricture and incontinence, but no detriment to quality of life, based on limited data. Given that the majority of men who have undergone a RP have a longer life expectancy, radiotherapy should be considered for those with high-risk features following radical prostatectomy. The optimal timing is unclear. PMID: 22161411 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Predicting erectile function outcome in men after radical prostatectomy for prostate cancer

BJU International — Tue, 20 Dec 2011 00:43:21 +0100

CONCLUSIONS• Men aged <60 years have a significant likelihood of regaining erectile function after radical prostatectomy.• The reported statistical model provides a reliable estimation of erectile function outcome after prostatectomy for men with localized prostate cancer and intact erectile function. (Source: BJU International)

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eNOS [Glu298Asp] polymorphism, erectile function and ocular pressure in type 2 diabetes

European Journal of Clinical Investigation — Mon, 19 Dec 2011 22:24:05 +0100

Conclusion: eNOS G894T gene polymorphism in homozygous TT carriers translates into opposing effects on erectile function (detrimental) and ocular hypertension/glaucoma (protective) in T2DM, without affecting glucose homeostasis determinants or the presence of micro‐ and macrovascular complications. (Source: European Journal of Clinical Investigation)

Safety and tolerability of local treatment with iloprost, a prostacyclin analogue, in patients with Peyronie's disease: a phase I study

BJU International — Fri, 16 Dec 2011 05:00:00 +0100

CONCLUSION• The results show that therapy with intralesional iloprost is a possible alternative to surgery for Peyronie's disease. (Source: BJU International)

Corpus Cavernosum Electromyography Revisited: Defining the Origin of the Signal

The Journal of Urology — Fri, 16 Dec 2011 05:00:00 +0100

Conclusions: This study confirms the penile cavernous tissue, and not the penile skin or surrounding tissue, as the origin of the corpus cavernosum electromyography complex. Further refinement of this technique may render it useful in the evaluation of neurogenic and myogenic erectile dysfunction. (Source: The Journal of Urology)

Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes

AJP: Endocrinology and Metabolism — Thu, 15 Dec 2011 05:00:00 +0100

In this study, we examine whether diabetes alters SMM expression, alternative splicing, and/or functional activities, including sensitivity to BLEB. By using streptozotocin (STZ)-induced 2-mo diabetic rats, functional activities were tested in vivo by intracavernous pressure (ICP) recording during cavernous nerve stimulation and in vitro via organ bath contractility studies. SMM isoform composition was analyzed by competitive RT-PCR and total SMM, myocardin, and embryonic SMM (SMemb) expression by real-time RT-PCR. Results revealed that the blood glucose level of STZ rats was 407.0 vs. 129.5 mg/dl (control). STZ rats exhibited ED confirmed by significantly increased CCSM contractile response to phenylephrine and decreased ICP response. For STZ rats, SM-B, LC17a and SM2 isoforms, total SMM,...

Apricus Biosciences' Vitaros(R) Podium Presentation Named Best Clinical Presentation 2011 (Male Sexual Disorder) by the Scientific Committee of the Congress for the European Society of Sexual Medicine Meeting in Milan

Medical News (via PRIMEZONE) — Mon, 12 Dec 2011 16:46:00 +0100

SAN DIEGO, Dec. 12, 2011 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. ("Apricus Bio" or the "Company") (Nasdaq:APRI) announced today that its podium presentation by Dr. Jacques Buvat on Vitaros(r), entitled, "Efficacy and Safety of Topical Alprostadil Cream (Vitaros(r)) in Hypertensive, Diabetic and Cardiac Patients with Male Erectile Dysfunction," was named the Best Clinical Presentation 2011 (Male Sexual Disorder ("MSD')) by the Scientific Committee of the Congress for the European Society of Sexual Medicine ("ESSM") that recently took place in Milan, Italy on December 1-4, 2011. The list of Best Clinical Presentation 2011 awards (MSD) can be viewed online at http://www.essm-congress.org/essm-awards.html. (Source: Medical News (via PRIMEZONE))

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Study finds impotence risk higher in men taking several drugs

Reuters: Health — Thu, 08 Dec 2011 22:17:05 +0100

NEW YORK (Reuters Health) - Men taking multiple medications for different health conditions may have a higher risk of erectile dysfunction -- a link that doesn't seem to be explained by the health problems themselves, a new study finds. (Source: Reuters: Health)

Study Finds Impotence Risk Higher in Men Taking Several Drugs

MedlinePlus Health News — Thu, 08 Dec 2011 22:17:03 +0100

Men taking multiple medications for different health conditions may have a higher risk of erectile dysfunction -- a link that doesn't seem to be explained by the health problems themselves, a new study finds.Source: Reuters Health Related MedlinePlus Pages: Erectile Dysfunction, Medicines (Source: MedlinePlus Health News)

South Central Priorities Committee recommends limiting prescriptions of erectile dysfunction drugs

NeLM - News — Thu, 08 Dec 2011 05:00:00 +0100

Source: BBC Health News, South Central Priorities Committee Area: News According to a BBC Health news report, GPs in Milton Keynes, Oxfordshire, Berkshire East, Berkshire West and Buckinghamshire, are being urged to limit prescriptions of erectile dysfunction drugs under new guidelines from the South Central Priorities Committee. The Committee had considered the evidence of clinical and cost-effectiveness, and the financial impact on the health economy of such treatments and made the following recommendations: 1. Treatment with phosphodiesterase type-5 inhibitors (sildenafil, vardenafil and tadalafil) at the minimum effective dose is recommended for the groups of patients identified in Health Service Circular (HSC) 1999/1771 at a maximum frequency of dosing of two ti...

Blood loss during radical prostatectomy: impact on clinical, oncological and functional outcomes and complication rates

BJU International — Wed, 07 Dec 2011 05:00:00 +0100

CONCLUSIONS• BL during ORRP does not adversely impact clinical and functional outcomes irrespective of how BL is defined.• Thus, the lower BL associated with robotic‐assisted laparoscopic prostatectomy (RALP) in and of itself would not be expected to improve functional or oncological outcomes. (Source: BJU International)

Erectile dysfunction

Multiple Sclerosis Trust — Wed, 07 Dec 2011 00:00:00 +0100

The South Central Priorities Committee, which covers health trusts in Oxfordshire, Berkshire, and Buckinghamshire, is recommending that drugs for erectile dysfunction be limited to two doses a month. It also suggests that counselling should not be offered for sexual problems. Existing NHS guidance limits treatment to people with certain conditions, including MS, but dosage is usually decided on an individual basis BBC Daily Telegraph Daily Mail Daily Mirror Sex and MS: a guide for men - book (Source: Multiple Sclerosis Trust)

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Prevalence and Predictors of Sexual Problems in Men Aged 75–95 Years: A Population‐Based Study

The Journal of Sexual Medicine — Tue, 06 Dec 2011 05:00:00 +0100

Conclusions. Sexual problems are common in elderly men. Chronic disease, depression, and insomnia appear to be the main modifiable risk factors. Androgen deficiency is unlikely to be a major cause of sexual problems in this age group. Hyde Z, Flicker L, Hankey GJ, Almeida OP, McCaul KA, Chubb SAP, and Yeap BB. Prevalence and predictors of sexual problems in men aged 75–95 years: A population‐based study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Exercise is Associated with Better Erectile Function in Men Under 40 as Evaluated by the International Index of Erectile Function

The Journal of Sexual Medicine — Tue, 06 Dec 2011 05:00:00 +0100

Conclusions. We have demonstrated that increased physical activity is associated with better sexual function measured by a validated questionnaire in a young, healthy population. Further studies are needed on the long‐term effects of exercise, or lack thereof, on erectile function as these men age. Hsiao W, Shrewsberry AB, Moses KA, Johnson TV, Cai AW, Stuhldreher P, Dusseault B, and Ritenour CWM. Exercise is associated with better erectile function in men under 40 as evaluated by the international index of erectile function. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Multipotent Stromal Cell Therapy for Cavernous Nerve Injury‐Induced Erectile Dysfunction

The Journal of Sexual Medicine — Tue, 06 Dec 2011 05:00:00 +0100

Conclusions. While the type of model may influence the mechanisms of action of this MSC‐based therapy, MSCs generally display efficacy in various animal models for ED. Before translation to the clinic is established, various hurdles need to be overcome. Albersen M, Kendirci M, Van der Aa F, Hellstrom WJG, Lue TF, and Spees JL. Multipotent stromal cell therapy for cavernous nerve injury‐induced erectile dysfunction. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

The Global Online Sexuality Survey (GOSS): Female Sexual Dysfunction among Internet Users in the Reproductive Age Group in the Middle East

The Journal of Sexual Medicine — Tue, 06 Dec 2011 05:00:00 +0100

Conclusion. Female sexual function in the reproductive age appears to be adversely affected by psychological factors and shortcomings in male sexual function more than anything. These findings point to the possibility that many cases of FSD can be managed with the focus on male partner's ailments and attitudes that are relatively easier to manage. Shae er O, Shaeer K, and Shaeer E. The Global Online Sexuality Survey (GOSS): Female sexual dysfunction among Internet users in the reproductive age group in the Middle East. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest.

Asian Journal of Andrology — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Hammoud AO, Carrell DT, Gibson M, Matthew Peterson C, Wayne Meikle A Abstract Obesity has a negative effect on male reproductive function. It is associated with low testosterone levels and alteration in gonadotropin secretion. Male obesity has been linked to reduced male fertility. Data regarding the relation of obesity to sperm parameters are conflicting in terms of the nature and magnitude of the effect. New areas of interest are emerging that can help explain the variation in study results, such as genetic polymorphism and sleep apnea. Sleep disorders have been linked to altered testosterone production and hypogonadism in men. It was also correlated to erectile dysfunction. The relation of sleep disorders to male fertility and sperm parameters remains to be investigated...

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Male sexual dysfunction and infertility associated with neurological disorders.

Asian Journal of Andrology — Mon, 05 Dec 2011 05:00:00 +0100

Authors: Fode M, Krogh-Jespersen S, Brackett NL, Ohl DA, Lynne CM, Sønksen J Abstract Normal sexual and reproductive functions depend largely on neurological mechanisms. Neurological defects in men can cause infertility through erectile dysfunction, ejaculatory dysfunction and semen abnormalities. Among the major conditions contributing to these symptoms are pelvic and retroperitoneal surgery, diabetes, congenital spinal abnormalities, multiple sclerosis and spinal cord injury. Erectile dysfunction can be managed by an increasingly invasive range of treatments including medications, injection therapy and the surgical insertion of a penile implant. Retrograde ejaculation is managed by medications to reverse the condition in mild cases and in bladder harvest of semen after ejaculati...

Men's Health in Primary Care: An Emerging Paradigm of Sexual Function and Cardiometabolic Risk.

The Urologic Clinics of North America — Sun, 04 Dec 2011 03:22:49 +0100

Authors: Miner MM Abstract An office evaluation of men's health in primary care requires a thorough understanding of the implications of male sexual dysfunctions, hypogonadism, and cardiometabolic risk stratification and aggressive risk management. The paradigm of the men's health office visit in primary care is the recognition and assessment of male sexual dysfunction, specifically erectile dysfunction, and its value as a signal of overall cardiometabolic health, including the emerging evidence linking low testosterone and the metabolic syndrome. Indeed, erectile dysfunction may now be thought of as a harbinger of cardiovascular clinical events and other systemic vascular diseases in some men. PMID: 22118341 [PubMed - in process] (Source: The Urologic Clinics of North America)

Sexual function in men with metabolic syndrome.

The Urologic Clinics of North America — Sun, 04 Dec 2011 03:22:10 +0100

Authors: Lee RK, Chughtai B, Te AE, Kaplan SA Abstract The metabolic syndrome (MetS) has become one of the major public health challenges worldwide. Emerging data have now clearly demonstrated its impact on male sexual function. The MetS appears to be strongly related to erectile dysfunction as well as hypogonadism. Few randomized studies exist to guide treatment of sexual dysfunction related to MetS; rather, most studies have been observational in nature. Medical therapy has formed the mainstay of treatment, with the advent of surgical intervention as a more recent phenomenon. PMID: 22118345 [PubMed - in process] (Source: The Urologic Clinics of North America)

Androgen deficiency in aging and metabolically challenged men.

The Urologic Clinics of North America — Sun, 04 Dec 2011 03:22:00 +0100

Authors: Shelton JB, Rajfer J Abstract Androgen deficiency in aging men is common, and the potential sequelae are numerous. In addition to low libido, erectile dysfunction, decreased bone density, depressed mood, and decline in cognition, studies suggest strong correlations between low testosterone, obesity, and the metabolic syndrome. Because causation and its directionality remain uncertain, the functional and cardiovascular risks associated with androgen deficiency have led to intense investigation of testosterone replacement therapy in older men. Although promising, evidence for definitive benefit or detriment is not conclusive, and treatment of late-onset hypogonadism is complicated. PMID: 22118346 [PubMed - in process] (Source: The Urologic Clinics of North America)

Influences of neuroregulatory factors on the development of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction in aging men.

The Urologic Clinics of North America — Sun, 04 Dec 2011 03:21:50 +0100

Authors: Mazur DJ, Helfand BT, McVary KT Abstract As men age, there is an increase in the frequency of pathologic diseases affecting the genitourinary tract. Most notable among these changes are the rising prevalence of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). The pathogenesis of these conditions seems to be multifactorial and includes age-related changes in the nervous system and neuroregulatory factors, such as nitric oxide and RhoA/Rho-kinase. Various pharmacologic agents that target these pathways, such as α-blockers and PDE-5is, underscore the contribution of neuroregulatory factors on the development of LUTS/BPH and ED. PMID: 22118347 [PubMed - in process] (Source: The Urologic Clinics of North Ame...

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New Benefits of Blockbuster Drug Cialis Discovered; Sales Expected To...

PRWeb: Medical Pharmaceuticals — Thu, 01 Dec 2011 19:16:33 +0100

Recent Research Supervised by the FDA Indicates Treatment with the Erectile Dysfunction Drug Tadalafil (Cialis) is Also Effective in the Treatment of Benign Prostatic Hyperplasia (BPH)....(PRWeb November 30, 2011)Read the full story at http://www.prweb.com/releases/2011/11/prweb8802338.htm (Source: PRWeb: Medical Pharmaceuticals)

ED increases with use of multiple medications

Modern Medicine — Thu, 01 Dec 2011 05:00:00 +0100

The use of multiple medications is associated with increased severity of erectile dysfunction, say researchers from Kaiser Permanente Los Angeles Medical Center. (Source: Modern Medicine)

Butea superba (Roxb.) improves penile erection in diabetic rats

Andrologia — Thu, 01 Dec 2011 05:00:00 +0100

Mitochondria and the heart * People's corner award: Thomas Thum * Outstanding Achievement Award from the ESC Council for Basic Cardiovascular Science * Book review * Evidence-based Management of Hypertension * Felix Zijlstra, head of cardiology at the Thoraxcenter Erasmus * Heart Lung and Circulation Journal * Percutaneous coronary intervention for vascular erectile dysfunction: a new area for cardiologists? * The Mediterranean diet, Part I

European Heart Journal — Thu, 01 Dec 2011 05:00:00 +0100

(Source: European Heart Journal)

Aortic/penile index is a marker of occult coronary artery disease in middle-aged hypertensive patients with erectile dysfunction

Artery Research — Thu, 01 Dec 2011 05:00:00 +0100

Background: It has been reported that there is a strict correlation between hypertension, erectile dysfunction (ED) and coronary artery disease (CAD), but the importance of an index to predict CAD in hypertensive ED patients needs to be addressed. (Source: Artery Research)

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Tobacco Abuse and the Urologist: Time for a More Proactive Role

Urology — Thu, 01 Dec 2011 05:00:00 +0100

The link between smoking and bladder cancer is solidly documented. The risk of developing renal cancer, for both transitional cell and renal cell, is also increased by tobacco abuse. Evolving data now strongly suggest that tobacco abuse is also associated with an increased risk of erectile dysfunction. In addition, an association has been suggested between smoking and testicular dysfunction with consequent infertility. (Source: Urology)

Multiple sclerosis - diagnosis, management and prognosis.

Australian Family Physician — Thu, 01 Dec 2011 05:00:00 +0100

This article summarises the diagnosis, management and prognosis of multiple sclerosis. Discussion Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses. Fifteen to 20% of patients will have a progressive course from the onset. There is significant interpatient variability in prognosis. The main diagnostic criteria are clinical, supported by investigations including magnetic resonance imaging and lumbar puncture and evoked potentials. First line disease modifying agents for relapsing remitting multiple sclerosis include interferon-ß and glatiramer. ...

An unusual surgical success with a defective penile prosthesis.

Canadian Urological Association Journal — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Zhao C, Choi BR, Jeong YB, Park JK Abstract A defective penile prosthesis is disconcerting for the surgeon performing an implantation in a patient with erectile dysfunction. We became aware of the defective Titan penile prosthesis just after insertion of the left cylinder, which had an abnormal rotation (180 degrees) due to abnormal rotated tubing, which occurred at the manufacturing plant. We successfully performed the implantation by cutting and re-connecting the tubing between the cylinder and pump with a spare connector. When the surgeon encounters a defective penile prosthesis with abnormal rotation of the cylinder due to abnormal rotated tubing in the operative field, disconnection and re-connection of the tubing using an extra connector are alternative cost-effectiv...

Erectile Dysfunction is the Main Determinant of Psychological Distress in Men with Spinal Cord Injury

The Journal of Sexual Medicine — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions. Healthcare providers should be aware of the importance of managing ED in spinal cord‐injured men, as it represents a major determinant of their psychological distress, independently of the degree of FI impairment. Barbonetti A, Cavallo F, Felzani G, Francavilla S, and Francavilla F. Erectile dysfunction is the main determinant of psychological distress in men with spinal cord injury. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Prevalence of late‐onset hypogonadism in men with type 2 diabetes mellitus

Andrologia — Thu, 01 Dec 2011 05:00:00 +0100

SummaryLate‐onset hypogonadism (LOH) or age‐associated testosterone deficiency syndrome is defined as a clinical and biochemical syndrome associated with advancing age and characterised by symptoms and a deficiency in serum testosterone levels. This condition may result in significant detriment in the quality of life and adversely affect the function of multiple organ systems. It has been suggested that sex steroid hormones may play a causal role in the development of insulin resistance and type II diabetes. This comparative study was aimed at determining the prevalence of LOH in diabetic men with erectile dysfunction and investigating the effect of testosterone replacement therapy on erectile function and on glycaemic control. (Source: Andrologia)

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Simultaneous analysis of sildenafil, vardenafil, tadalafil, and their desalkyl metabolites in human whole blood and urine by isotope dilution LC–MS–MS

Forensic Toxicology — Mon, 28 Nov 2011 16:50:56 +0100

In this study, we established a detailed procedure for simultaneous analysis of typical ED drugs (sildenafil, vardenafil, tadalafil) and their metabolites in human blood and urine by isotope dilution liquid chromatography-tandem mass spectrometry (LC–MS–MS). Each sample of whole blood and urine containing the three ED treatment drugs, their metabolites, and deuterated internal standards (ISs) was diluted with alkalinized water, loaded onto an Oasis HLB cartridge, washed with dilute ammonium hydroxide solution, and eluted with chloroform. The eluate was acidified with methanol and concentrated HCl and evaporated to dryness. The resulting residue was reconstituted with methanol and mobile phase solution, and 5 μl of the solution was injected into an LC–MS–MS instrument. T...

Should patients with erectile dysfunction be evaluated for cardiovascular disease?

Asian Journal of Andrology — Mon, 28 Nov 2011 05:00:00 +0100

Authors: Ewane KA, Lin HC, Wang R Abstract The landmark Massachusetts Male Ageing Study shed new light on the prevalence of erectile dysfunction (ED) and drew attention to ED as a disease of ageing. Over the years, ED has been linked to the development of cardiovascular disease (CVD) in some patients. There is clear evidence that ED and CVD share and have a similar risk factor profile. CVD is one of the most recognizable causes of mortality and early detection coupled with prevention of mortality from CVD has been the prime interest of many researchers. Consequently, there has been a multidisciplinary curiosity regarding the proposal to use ED as a marker for future CVD. In fact, there have been several proposals to use ED as a screening tool for future CVD. We performed a comprehe...

Men’s Health in Primary Care: An Emerging Paradigm of Sexual Function and Cardiometabolic Risk

Urologic Clinics of North America — Sat, 26 Nov 2011 01:33:58 +0100

An office evaluation of men's health in primary care requires a thorough understanding of the implications of male sexual dysfunctions, hypogonadism, and cardiometabolic risk stratification and aggressive risk management. The paradigm of the men's health office visit in primary care is the recognition and assessment of male sexual dysfunction, specifically erectile dysfunction, and its value as a signal of overall cardiometabolic health, including the emerging evidence linking low testosterone and the metabolic syndrome. Indeed, erectile dysfunction may now be thought of as a harbinger of cardiovascular clinical events and other systemic vascular diseases in some men. (Source: Urologic Clinics of North America)

A survey on relative frequency of metabolic syndrome and testosterone deficiency in men with erectile dysfunction

International Urology and Nephrology — Thu, 24 Nov 2011 17:45:31 +0100

Conclusion The relative frequencies of metabolic syndrome and testosterone deficiency in men with ED seem to be significant, and it is the time that we should evaluate ED not as a disease but as a presentation of multiple underlying pathologies which needs medical attention to general health. Content Type Journal ArticleCategory Urology - Original PaperPages 1-6DOI 10.1007/s11255-011-0086-8Authors Ali Hamidi Madani, Urology Research Center, Guilan University of Medical Sciences, Razi Hospital, Sardar Jangal St, Rasht, IranAbtin Heidarzadeh, Urology Research Center, Guilan University of Medical Sciences, Razi Hospital, Sardar Jangal St, Rasht, IranNiloofar Akbari Parsa, Urology Research Center, Guilan University of Medical Sciences, Razi Hospital, Sardar Jangal St, R...