MedWorm: Hole in the Heart

Anatomical observations of the moderator band

Clinical Anatomy — Tue, 16 Mar 2010 00:00:00 +0100

We present these data that may prove useful in the setting of the surgical repair of apical ventricular septal defects through the right atrium. Clin. Anat. 2010. © 2010 Wiley-Liss, Inc. (Source: Clinical Anatomy)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Impact of Transcatheter Atrial Septal Defect Closure in the Older Population: A Prospective Study

Journal of the American College of Cardiology: Cardiovascular Interventions — Mon, 15 Mar 2010 20:59:21 +0100

Conclusions Our data demonstrated that ASD closure at advanced age results in favorable cardiac remodeling and improvement of functional class. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)

Indications and Outcomes of Surgical Closure of Ventricular Septal Defect in Adults

Journal of the American College of Cardiology: Cardiovascular Interventions — Mon, 15 Mar 2010 20:59:21 +0100

Conclusions Associated heart defects and AR were common indications for VSD closure in adults, which was performed with low mortality and morbidity. Patch closure and use of intraoperative transesophageal echocardiography improve surgical outcomes. Important residua emphasize the need for life-long informed follow-up. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)

The Arterial Switch Operation: The “Open” Technique for Coronary Transfer

Operative Techniques in Thoracic and Cardiovascular Surgery: A Comparative Atlas — Mon, 15 Mar 2010 16:57:36 +0100

At Children's Medical Center Dallas, the arterial switch operation is routinely performed with bicaval cannulation, continuous cardiopulmonary bypass (CPB), and moderate hypothermia of 25 to 28°C. Methylprednisolone (10 mg/kg IV) is administered 8 to 12 hours preoperatively. A pH stat strategy is typically employed with a hematocrit target of 35%. Phentolamine (0.2 g/kg) is administered for [alpha]-adrenergic blockade after initiating CPB. Flow rates vary between 150 and 200 mL/kg/min at normothermia, and 75 and 125 mL/kg/min at hypothermia. Cerebral and flank near-infrared spectroscopy indices are monitored routinely and used (in addition to continuous blood gas analysis) to assess the adequacy of perfusion. Associated intracardiac defects except for the atrial septal defect, which facil...

Can intraoperative TEE correctly measure residual shunt after surgical repair of ventricular septal defects?

Journal of Anesthesia — Sun, 14 Mar 2010 11:25:14 +0100

Conclusion TEE-derived Qp/Qs lacks the accuracy required to play a crucial role in quantitatively measuring the severity of residual shunt, while two-dimensional TEE can reliably detect residual leakage after VSD closure and lead to optimal judgment on the need for re-repair. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-010-0896-3Authors Satoshi Kurokawa, Tokyo Women’s Medical University Department of Anesthesiology, Faculty of Medicine 8-1 Kawadacho, Shinjuku-ku Tokyo 162-8666 JapanTakayuki Honma, Niigata University Department of Anesthesiology, Faculty of Medicine Niigata JapanMiki Taneoka, Niigata University Department of Anesthesiology, Faculty of Medicine Niigata JapanHidekazu Imai, Niigata University Department of Anesthesiology, F...

Letter to the editor: Comment on: Late detection of noncompaction of the myocardium in an adult with complete interventricular septal defect.

Turk Kardiyoloji Dernegi arsivi — Fri, 12 Mar 2010 11:50:04 +0100

Authors: Sezen Y, Yıldız A PMID: 20215853 [PubMed - as supplied by publisher] (Source: Turk Kardiyoloji Dernegi arsivi)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

[Percutaneous closure of two atrial septal defects with individual septal occluder devices.]

Turk Kardiyoloji Dernegi arsivi — Fri, 12 Mar 2010 11:50:04 +0100

Authors: Ilkay E, Fırat S, Dağlı N, Ozeke O A 20-year-old male patient presented with dyspnea and palpitation. An atrial shunt was detected on transthoracic echocardiography. Transesophageal echocardiography (TEE) showed two secundum atrial septal defects (ASD), 13 mm and 15 mm in size, respectively. There was no other congenital heart disease. During right heart catheterization, pulmonary artery pressure was 40 mmHg and the Qp/Qs ratio was 1.9. His coronary arteries were normal. The patient underwent elective percutaneous ASD closure under general anesthesia and continuous TEE monitoring. The distance between the two defects was 16 mm. Two 25-mm PTS sizing balloon catheters were simultaneously inflated, yielding maximum defect diameters of 13 mm and 15 mm. First the ...

[Evaluation of adult congenital heart diseases.]

Turk Kardiyoloji Dernegi arsivi — Fri, 12 Mar 2010 11:50:04 +0100

CONCLUSION: In our study, atrial and ventricular septal defects accounted for the majority of CHDs in adult patients (69.5%). Multicenter studies are required to determine the incidence of CHD among adult population in Turkey. PMID: 20215839 [PubMed - as supplied by publisher] (Source: Turk Kardiyoloji Dernegi arsivi)

Congenital Left Main Coronary Artery to Main Pulmonary Artery Fistula with Bicuspid Aortic Valve: A Case Report and Review of Literature

Journal of Cardiac Surgery — Mon, 08 Mar 2010 00:00:00 +0100

We report on a 68-year-old man with congenital left main to pulmonary artery fistula associated with bicuspid aortic valve and moderate aortic stenoses, who underwent successful aortic valve replacement with ligation of CAF and also review the natural history, pathophysiology, and management of CAF. (J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)

Heterogeneity of Genetic Modifiers Ensures Normal Cardiac Development.

Circulation — Mon, 08 Mar 2010 00:00:00 +0100

Conclusions-Alleles of modifier genes can either buffer perturbations on cardiac development or direct the manifestation of a defect. In a genetically heterogeneous population, the predominant effect of modifier genes is health. PMID: 20212279 [PubMed - as supplied by publisher] (Source: Circulation)

Radiofrequency Catheter Ablation of Parasystole Originating from the Inferior Vena Cava

Pacing and Clinical Electrophysiology : PACE — Fri, 05 Mar 2010 00:00:00 +0100

A 76-year-old man with a history of atrial septal defect repair underwent radiofrequency (RF) ablation of typical atrial flutter. During electrophysiological study, incessant sharp potentials were recorded, originating from the ostium of the inferior vena cava (IVC), and dissociated from atrial activity. During sinus rhythm, these potentials propagated to the atria and caused premature complexes when falling beyond the atrial refractory period. Electro-anatomical mapping revealed the presence of the earliest potential in the postero-lateral ostium of the IVC, propagating to the septal region. After RF isolation of the IVC, the patient has remained arrhythmia-free over a 5-year follow-up. (PACE 2010; e1[ndash]e4) (Source: Pacing and Clinical Electrophysiology : PACE)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Pregnancy Complications Differ With Repaired Vs. Unrepaired Ventricular Septal Defect

Medscape Ob/Gyn & Women's Health Headlines — Wed, 03 Mar 2010 17:26:04 +0100

Pregnant women with isolated ventricular septal defects face different complications depending on whether the defect has been repaired or not, researchers say. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)

Paxil Birth Defect Trial: Battle of the Experts

NaturalNews.com — Tue, 02 Mar 2010 07:00:00 +0100

(NaturalNews) In the first Paxil birth defect trial that resulted in a $2.5 million verdict against GlaxoSmithKline in October 2009, the infant, Lyam Kilker, was born with three heart defects; an atrial septal defect, a ventricular septal defect, and an interrupted aortic arch, after his mother took Paxil while pregnant. Pregnant women cannot participate in clinical trials on drugs due to the risk of harm to the fetus. But after a drug has been on the market for a while, epidemiology studies can review the medical records of women who have taken a new drug while pregnant and the records of women who were not exposed to the drug while pregnant and compare the outcomes of the infants.The plaintiff's experts, Doctors Ra-id Abdulla, David Healy, Shira Kramer and Suzanne Parisian, all testified...

Author response: B-type natriuretic peptide for cardiovascular events independent of left ventricular end-diastolic pressure

American Heart Journal — Mon, 01 Mar 2010 00:00:00 +0100

Thank you for your interest in our study. We agree that the clinical application of B-type natriuretic peptide (BNP) as a prognostic marker is still evolving. We do believe that the body of evidence supports a relationship between BNP and left ventricular end-diastolic pressure in adults with left ventricular dysfunction. The lack of such a relationship in the study by Oyamada et al may instead be related to their unique study population of infants with ventricular septal defects. The issue of false positives as a limitation to BNP testing is acknowledged but may be more germane to the use of BNP as a diagnostic, rather than a prognostic, marker and reinforces that the strength of BNP as a diagnostic test is its high negative predictive value. Nonetheless, implementation of BNP into clinic...

Update on the Pediatric and Congenital Heart Disease Track for ASE 2010

Journal of the American Society of Echocardiography — Mon, 01 Mar 2010 00:00:00 +0100

The Pediatric and Congenital Heart Disease (CHD) Track for ASE 2010 promises to be full of science, education, and imaging pearls for the pediatric and adult congenital echocardiography community. The program will begin on Saturday with sessions correlating issues in pathology, echocardiography, surgery, and long-term follow-up for three complex congenital malformations, specifically atrioventricular canal (septal) defect, hypoplastic left heart syndrome, and complex transposition of the great arteries. The pathology perspective will be provided by Dr. Andrew Cook from Great Ormond Street in London, where he worked for many years with Professor Robert Anderson. The surgical perspective will be provided by Dr. Victor Morrell from the University of Pittsburgh. The other presentations in thes...

Sutureless rescue of a severely hypoplastic pulmonary artery [Case reports]

European Journal of Cardio-Thoracic Surgery — Fri, 26 Feb 2010 22:01:57 +0100

The management of severely hypoplastic pulmonary arteries in the adolescent or adult with congenital heart disease is challenging. A patient with pulmonary atresia and ventricular septal defect (PA-VSD) presented with severe cyanosis due to a kinked and thrombosed right ventricle to pulmonary artery conduit. Retrograde wedge angiography showed a patent right and a diminutive left pulmonary artery deep in the lung hilus. Treatment options were limited and therefore a different strategy had to be considered to rescue the lung segments. This case report describes the novel use of a covered stent to successfully obtain a sutureless connection between a vascular graft and a diminutive pulmonary artery during a hybrid procedure. (Source: European Journal of Cardio-Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Effects of Morphologic Left Ventricular Pressure on Right Ventricular Geometry and Tricuspid Valve Regurgitation in Patients With Congenitally Corrected Transposition of the Great Arteries

The American Journal of Cardiology — Fri, 26 Feb 2010 13:53:29 +0100

In conclusion, these data indicate that LV pressure in patients with CCTGA affects the degree of TR and that septal shift caused by changes in LV and RV pressure is an important mechanism. (Source: The American Journal of Cardiology)

Intraatrial Baffle Repair of Anomalous Systemic Venous Return Without Hepatic Venous Drainage in Heterotaxy Syndrome

Pediatric Cardiology — Wed, 24 Feb 2010 06:47:08 +0100

This report describes an intraatrial baffle repair of anomalous systemic venous return without hepatic venous drainage. This resulted in good oxygenation postoperatively, with oxygen saturation ranging from 93% to 98%. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00246-010-9686-9Authors Rıza Turkoz, İstanbul Teaching and Medical Research Center, Baskent University Department of Cardiovascular Surgery Istanbul TurkeyCanan Ayabakan, İstanbul Teaching and Medical Research Center, Baskent University Department of Pediatric Cardiology Istanbul TurkeyCan Vuran, İstanbul Teaching and Medical Research Center, Baskent University Department of Cardiovascular Surgery Istanbul TurkeyOğuz Omay, İstanbul Teaching and Medical Research Center, Baskent University Department o...

Symptomatic Neonatal Tetralogy of Fallot: Repair or Shunt? [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 22:46:26 +0100

Conclusions Shunting or primary repair of neonates with symptomatic TOF provides equivalent mortality and results. Shunted patients had fewer transannular patch repairs despite having more emergent initial operations. Compared with the primary repair group, shunted patients had decreased intensive care unit and hospital stays for the first hospitalization, which were neutralized when the second operation (repair) values were added. (Source: The Annals of Thoracic Surgery)

The Nuss Procedure for Pectus Excavatum at the Time of Atrial Septal Closure [CASE REPORTS]

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 22:46:26 +0100

A 25-year-old man with severe pectus excavatum and an atrial septal defect had simultaneous repair of the defects, using a patch for closure of the defect and placement of a Nuss bar for the chest wall defect. Details of the procedure and outcome are described. (Source: The Annals of Thoracic Surgery)

Symptomatic Neonatal Tetralogy of Fallot: Repair or Shunt?

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 13:10:33 +0100

CONCLUSIONS: Shunting or primary repair of neonates with symptomatic TOF provides equivalent mortality and results. Shunted patients had fewer transannular patch repairs despite having more emergent initial operations. Compared with the primary repair group, shunted patients had decreased intensive care unit and hospital stays for the first hospitalization, which were neutralized when the second operation (repair) values were added. PMID: 20172143 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Nuss Procedure for Pectus Excavatum at the Time of Atrial Septal Closure.

The Annals of Thoracic Surgery — Tue, 23 Feb 2010 13:08:47 +0100

Authors: Kao CH, Tsai CS, Huang TW, Lee SC, Cheng YL A 25-year-old man with severe pectus excavatum and an atrial septal defect had simultaneous repair of the defects, using a patch for closure of the defect and placement of a Nuss bar for the chest wall defect. Details of the procedure and outcome are described. PMID: 20172179 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)

Left Ventricular Myxoma Accompanied with Congenital Atrial Septal Defect

Journal of Cardiac Surgery — Tue, 23 Feb 2010 00:00:00 +0100

(J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)

Persistent iatrogenic atrial septal defect after a single-puncture, double-transseptal approach for pulmonary vein isolation using a remote robotic navigation system: results from a prospective study

Europace — Sat, 20 Feb 2010 14:44:32 +0100

Conclusion After a single-puncture, double-transseptal approach for PVI using the RNS, iASDs show a high spontaneous closure rate of 78.9% after a 6-month FU period. Persistent iASDs following PVI with the RNS are not associated with an increased rate of paradoxical embolism or with relevant shunting. (Source: Europace)

Multimodality imaging of a pacemaker lead crossing a primum atrial septal defect

Europace — Sat, 20 Feb 2010 14:44:32 +0100

(Source: Europace)

Iatrogenic atrial septal defect after catheter ablation of atrial fibrillation: do we have to worry?

Europace — Sat, 20 Feb 2010 14:44:31 +0100

(Source: Europace)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function [Cell Biology]

Journal of Biological Chemistry — Fri, 19 Feb 2010 14:39:20 +0100

Calcineurin is a protein phosphatase that is uniquely regulated by sustained increases in intracellular Ca2+ following signal transduction events. Calcineurin controls cellular proliferation, differentiation, apoptosis, and inducible gene expression following stress and neuroendocrine stimulation. In the adult heart, calcineurin regulates hypertrophic growth of cardiomyocytes in response to pathologic insults that are associated with altered Ca2+ handling. Here we determined that calcineurin signaling is directly linked to the proper control of cardiac contractility, rhythm, and the expression of Ca2+-handling genes in the heart. Our approach involved a cardiomyocyte-specific deletion using a CnB1-LoxP-targeted allele in mice and three different cardiac-expressing Cre alleles/transgenes. D...

Zac1 Is an Essential Transcription Factor for Cardiac Morphogenesis.

Circulation Research — Thu, 18 Feb 2010 00:00:00 +0100

Conclusions: Zac1 plays an essential role in the cardiac gene regulatory network. Our data provide a potential mechanistic link between Zac1 in cardiogenesis and congenital heart disease manifestations associated with genetic or epigenetic defects in an imprinted gene network. PMID: 20167925 [PubMed - as supplied by publisher] (Source: Circulation Research)

Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.

The American Journal of Clinical Nutrition — Wed, 17 Feb 2010 00:00:00 +0100

CONCLUSIONS: Low dietary choline and riboflavin affect embryonic growth and cardiac development in mice. Adequate choline and riboflavin may also play a role in the prevention of these pregnancy complications in women. PMID: 20164309 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)

Articles Appearing in the Next Issue

Journal of Electrocardiology — Tue, 16 Feb 2010 13:59:21 +0100

(Source: Journal of Electrocardiology)

Temporary tricuspid valve leaflet detachment for closure of perimembranous ventricular septal defect: Early experiences

Indian Journal of Thoracic and Cardiovascular Surgery — Mon, 15 Feb 2010 17:46:52 +0100

Conclusions This study suggests that TVD is a safe, effective and technically easy method in the armamentarium of cardiac surgeon that improves exposure of posterosuperior boundary of pVSD, decreases undue traction over tricuspid valve leaflets and does not adversely affect tricuspid valve competence and results in decreased incidence of residual VSD, TR and conduction disturbances. Content Type Journal ArticleDOI 10.1007/s12055-009-0032-xAuthors Neeraj Kumar, L.P.S. Institute of Cardiology and Cardiac Surgery Department of Cardio Vascular and Thoracic Surgery Kanpur Uttar Pradesh IndiaSunil Dixit, L.P.S. Institute of Cardiology and Cardiac Surgery Department of Cardio Vascular and Thoracic Surgery Kanpur Uttar Pradesh IndiaRajat Agrawal, L.P.S. Institute of Cardiolog...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect

BJOG: An International Journal of Obstetrics and Gynaecology — Mon, 15 Feb 2010 00:00:00 +0100

Conclusions Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect.

BJOG : An International Journal of Obstetrics and Gynaecology — Mon, 15 Feb 2010 00:00:00 +0100

Conclusions Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD. PMID: 20156207 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Segmental Pigmentation Disorder.

The British Journal of Dermatology — Mon, 15 Feb 2010 00:00:00 +0100

Conclusions: Segmental Pigmentation Disorder is a relatively common pigmentary anomaly and most affected individuals are otherwise healthy. We propose reviving the term coined by Metzker et al, "Segmental pigmentation disorder" to describe children with segmental and block-like hypo/ hyper pigmentation with midline demarcation. PMID: 20163411 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands

European Heart Journal — Sun, 14 Feb 2010 08:06:03 +0100

Conclusion Our results support the hypothesis that additional periconceptional folic acid use reduces CHD risk in infants. Use of periconceptional folic acid supplements was related to ~20% reduction in the prevalence of any CHD. Given the relatively high prevalence of CHD worldwide, our findings are important for public health. (Source: European Heart Journal)

Mechanical valve dysfunction after percutaneous perimitral leak closure: Salvage by percutaneous occluder retrieval

Catheterization and Cardiovascular Interventions — Tue, 09 Feb 2010 00:00:00 +0100

We describe a patient with two perimitral defects who developed severe mitral stenosis due to mitral leaflet impingement after percutaneous implantation of three amplatzer muscular ventricular septal defect occluder devices. The largest amplatzer occluder device was successfully snared with restoration of normal prosthetic valve motion. © 2010 Wiley-Liss, Inc. (Source: Catheterization and Cardiovascular Interventions)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Long-Term Outcomes of Patients With Cardiovascular Abnormalities and Williams Syndrome

The American Journal of Cardiology — Mon, 08 Feb 2010 00:00:00 +0100

In conclusion, CVAs are common in patients with WS, but supravalvar aortic stenosis and peripheral pulmonary stenosis occurred less frequently in this large cohort than previously reported. In patients with WS and CVAs, interventions are common and usually occur by 5 years of age. Most patients with WS do not require intervention during long-term follow-up, and the overall mortality has been low. (Source: The American Journal of Cardiology)

Rudhe syndrome: reversible right middle lobe emphysema in infants with left-to-right shunts—an historical review

Pediatric Radiology — Fri, 05 Feb 2010 08:33:56 +0100

Abstract In 1971, the Swedish radiologist Ulf Rudhe wrote a provocative paper on right middle lobe emphysema in infants with left-to-right shunts in which he suggested cardiac surgery rather than lung resection. At the time, this was counter to accepted medical practice. Earlier diagnosis and better medical management of ventricular septal defect in infants has proved Rudhe correct. However, two current cases of large left-to-right shunts in infants with emphysema of the right middle lobe prompt this historical review of what seemed a closed-episode in pediatric cardiac surgery. Content Type Journal ArticleCategory Historical PerspectiveDOI 10.1007/s00247-009-1530-0Authors Lee K. Collins, Schneiders Children’s Hospital Department of Radiology Manhasset NY USATerry L. ...

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development.

Developmental Biology — Fri, 05 Feb 2010 00:00:00 +0100

Authors: Holler KL, Hendershot TJ, Troy SE, Vincentz JW, Firulli AB, Howard MJ The basic helix-loop-helix DNA binding protein Hand2 has critical functions in cardiac development both in neural crest-derived and mesoderm-derived structures. Targeted deletion of Hand2 in the neural crest has allowed us to genetically dissect Hand2-dependent defects specifically in outflow tract and cardiac cushion independent of Hand2 functions in mesoderm-derived structures. Targeted deletion of Hand2 in the neural crest results in misalignment of the aortic arch arteries and outflow tract, contributing to development of double outlet right ventricle (DORV) and ventricular septal defects (VSD). These neural crest-derived developmental anomalies are associated with altered expression of Hand2-target gene...

Percutaneous successful closure of dual atrial septal defect with two Amplatzer septal occluder devices

Clinical Research in Cardiology — Wed, 03 Feb 2010 17:55:26 +0100

We report a case of percutaneous dual atrial septal defect closure with two Amplatzer septal occluder devices. Content Type Journal ArticleCategory Clinical CorrespondenceDOI 10.1007/s00392-010-0124-zAuthors Hamza Duygu, Ataturk Training and Research Hospital Izmir TurkeyHalit Acet, Ataturk Training and Research Hospital Izmir TurkeyUgur Kocabas, Ataturk Training and Research Hospital Izmir TurkeyZehra Ilke Akyildiz, Ataturk Training and Research Hospital Izmir TurkeyCem Nazli, Ataturk Training and Research Hospital Izmir TurkeyOktay Ergene, Ataturk Training and Research Hospital Izmir Turkey Journal Clinical Research in CardiologyOnline ISSN 1861-0692Print ISSN 1861-0684 (Source: Clinical Research in Cardiology)

Right Ventricular Function Suffers From Reperfusion Delay: Tissue Doppler Study

Clinical Cardiology — Tue, 02 Feb 2010 00:00:00 +0100

In this study, impact of reperfusion delay on adverse cardiac events and right ventricular (RV) function in patients with acute right ventricular myocardial infarction (RVMI) was assessed. In 70 patients with RVMI, RV function was assessed by M-mode tricuspid annular plane systolic excursion (TAPSE) and by pulsed wave tissue Doppler echocardiography (TDE). Right ventricular early (E[prime]T) and late diastolic (A[prime]T), peak systolic tricuspid annular velocity, (S[prime]T) and right ventricular myocardial performance index (RVMPI) were measured. Patients were divided into 2 groups according to the time between the onset of symptoms and percutaneous transluminal coronary angioplasty (PTCA) - group 1 (n = 25), [le]3 hours and group 2 (n = 45), > 3 hours. During 30-day follow-up, we assess...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Brain Abscess in an Adult With Atrial Septal Defect

Clinical Cardiology — Tue, 02 Feb 2010 00:00:00 +0100

This article describes the case of a 41-year-old man who presented with altered mental status. Brain MRI showed a brain abscess at the left frontal lobe. The patient was successfully treated with surgical removal and appropriate antibiotics. Echocardiographic examination showed atrial septal defect (ASD) with bidirectional shunt. Transcatheter closure of ASD was carried out 6 months after neurosurgical treatment. We discuss the association of brain abscess and ASD. Copyright © 2009 Wiley Periodicals, Inc. (Source: Clinical Cardiology)

Cardiac malformations and alteration of TGF[beta] signaling system in diabetic embryopathy

Birth Defects Research Part B: Developmental and Reproductive Toxicology — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Maternal diabetes causes malformations in the heart of the embryo. The heart is more susceptible to maternal diabetic insults than the neural tube. Malformations in the heart prior to septation are associated with decreased cell proliferation, but not increased apoptosis. The TGF[beta] signaling is involved in cardiac malformations in diabetic embryopathy. Birth Defects Res (Part B) XX:1-9, 2010. © 2010 Wiley-Liss, Inc. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)

Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model.

Circulation — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions-Under real-time ultrasound guidance, atrial septal defects were successfully created with extracardiac histotripsy in a live canine model. Although further studies in an intact animal model are needed, these results provide promise of histotripsy becoming a valuable clinical tool. PMID: 20124126 [PubMed - as supplied by publisher] (Source: Circulation)

Successful staged Fontan completion for truncus arteriosus with hypoplastic left ventricle.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

We report a case of truncus arteriosus type II with a large outlet ventricular septal defect and a hypoplastic left ventricle. The first-stage palliation was the removal of both branch pulmonary arteries from the ascending aorta, patch augmentation of the pulmonary artery confluence, and modified Blalock-Taussig shunt at age 1 month. The second stage palliation was a bidirectional Glenn at 6 months. The final stage was an extracardiac Fontan at age 3 years. Eight years later, the patient is doing well, with an unobstructed Fontan pathway and mild-to-moderate truncal valve insufficiency. PMID: 20103368 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

Outcomes using predominantly single-stage approach to interrupted aortic arch and associated defects.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: A good functional outcome and low reoperation rate can be achieved with a single-stage repair regardless of the presence of major additional cardiac abnormalities. Neonates with risk factors such as low birth weight and prematurity require an individualized approach. PMID: 20103342 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Ventricular septal defects closure using a minimal right vertical infraaxillary thoracotomy: seven-year experience in 274 patients.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: The RVIAT can be performed with favorable cosmetic and clinical results for VSD closure. It provides a good alternative to standard median sternotomy for VSD patients. PMID: 20103340 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

Current expectations for surgical repair of isolated ventricular septal defects.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Surgical closure of isolated VSD is a safe, effective therapy. Risk of death, complete heart block, and reoperation is minimal. As new technologies for VSD closure evolve, results such as these should be considered when evaluating patients, choosing therapeutic options, and counseling families. PMID: 20103339 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

Biventricular repair of atrioventricular septal defect with common atrioventricular valve and double-outlet right ventricle.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Although technically challenging, the surgical repair can be accomplished with acceptable early results. Heterotaxy syndrome, with concurrent anomalous connections of the pulmonary veins, represented the strongest identified risk factor for death or significant complication. PMID: 20103338 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

Partial and transitional atrioventricular septal defect outcomes.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Surgical repair for partial/transitional AVSD is associated with low morbidity and mortality, short hospital stays, and catch-up growth, particularly in underweight children repaired between 3 and 18 months of age. Left atrioventricular valve regurgitation remains the most common residual defect, occurring more frequently in children repaired after 4 years of age. PMID: 20103337 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

Concomitant septal myectomy at the time of aortic valve replacement for severe aortic stenosis.

The Annals of Thoracic Surgery — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: A quantitative assessment of the obstructive ABSH in the setting of severe aortic stenosis may be difficult preoperatively. Surgeons should inspect left ventricular outflow tract for possible obstructive ABSH at the time of AVR. Concomitant myectomy is a safe and effective procedure without additional complications and should be considered for patients with a preoperative or intraoperative diagnosis of ABSH even though dynamic obstruction was not demonstrated. PMID: 20103321 [PubMed - indexed for MEDLINE] (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

A novel two-stage complete repair method for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries.

Chinese Medical Journal — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: This two-stage complete repair strategy was well-tolerated and effective with good outcome, thus offering an alternative surgical approach in the treatment of PA-VSD and MAPCAs. PMID: 20193241 [PubMed - in process] (Source: Chinese Medical Journal)

Residual atrial septal defect after percutaneous closure with an Amplatzer device [Images in cardio-thoracic surgery]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:37 +0100

(Source: European Journal of Cardio-Thoracic Surgery)

Long-term results after mitral valve repair in children [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: MV repair in children showed excellent survival, acceptable re-operation rate and satisfactory valve function at long-term follow-up. Residual MV dysfunction was a significant risk factor for re-operation, but re-repair was successful in more than half of the patients who underwent re-operation. (Source: European Journal of Cardio-Thoracic Surgery)

Re-repair of the left atrioventricular valve in atrioventricular septal defects: the morphologic approach to the role of Gore-tex band reduction annuloplasty [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Left atrioventricular valve incompetence following previous repair usually involves repair of the zone of apposition between the left bridging leaflets. Many of these valves also require annuloplasty to attain competence. Given the shape, growth potential and morphologic composition of the annulus in these cases, we have performed some of these repairs with a partial flexible ring from a thin-walled 3.5-mm Gore-Tex graft as a reduction annuloplasty that can be shaped to fit the exact contours of this annulus. (Source: European Journal of Cardio-Thoracic Surgery)

Ross and Yasui operations for complex biventricular repair in infants with critical left ventricular outflow tract obstruction [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Case selection is key for complex biventricular repair and the importance of appropriate case selection is exaggerated at young ages. All available options should be considered before pursuing the Ross operation in the presence of co-existing functional morphological abnormalities or emergent iatrogenic aortic regurgitation. However, both the Ross and Yasui operations in children (including neonates and young infants) with favourable functional morphology offer good survival, at least matching that of other biventricular repair strategies. (Source: European Journal of Cardio-Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Dilatable pulmonary artery banding in infants with low birth weight or complex congenital heart disease allows avoidance or postponement of subsequent surgery [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Dilation of both main and bilateral branch pulmonary artery bands is possible, effective and safe. Dilatable main pulmonary artery bands allow for progressive dilation with postponement of surgery or complete release of the bands. Bilateral dilatable branch pulmonary bands offer palliative benefit, especially in hybrid cases where pulmonary blood flow may be limited by the bands before the ideal conditions for a stage II procedure exist. (Source: European Journal of Cardio-Thoracic Surgery)

Totally endoscopic closure of an atrial septal defect using the da vinci surgical system: Report of four cases

Surgery Today — Wed, 27 Jan 2010 20:05:42 +0100

This report presents four cases of totally endoscopic closure of an atrial septal defect using the da Vinci Surgical System (Intuitive Surgical, Mountain View, CA, USA). The patients were diagnosed with an ostium secundum atrial septal defect and elected to undergo minimally invasive surgery. A cardiopulmonary bypass was established via cannulation of the femoral vessel and jugular vein, and blood cardioplegic arrest was induced using a transthoracic cross-clamp. The mean extracorporeal circulation and cardiac arrest times were 86 ± 21 and 22 ± 8 min, respectively. No patient experienced pain after surgery, and all were fast-tracked for early discharge and released on postoperative day 3. No intraoperative or postoperative complications occurred. This procedure permitted a short ho...

Partial and Transitional Atrioventricular Septal Defect Outcomes [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Surgical repair for partial/transitional AVSD is associated with low morbidity and mortality, short hospital stays, and catch-up growth, particularly in underweight children repaired between 3 and 18 months of age. Left atrioventricular valve regurgitation remains the most common residual defect, occurring more frequently in children repaired after 4 years of age. (Source: The Annals of Thoracic Surgery)

Biventricular Repair of Atrioventricular Septal Defect With Common Atrioventricular Valve and Double-Outlet Right Ventricle [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Although technically challenging, the surgical repair can be accomplished with acceptable early results. Heterotaxy syndrome, with concurrent anomalous connections of the pulmonary veins, represented the strongest identified risk factor for death or significant complication. (Source: The Annals of Thoracic Surgery)

Current Expectations for Surgical Repair of Isolated Ventricular Septal Defects [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Surgical closure of isolated VSD is a safe, effective therapy. Risk of death, complete heart block, and reoperation is minimal. As new technologies for VSD closure evolve, results such as these should be considered when evaluating patients, choosing therapeutic options, and counseling families. (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Ventricular Septal Defects Closure Using a Minimal Right Vertical Infraaxillary Thoracotomy: Seven-Year Experience in 274 Patients [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions The RVIAT can be performed with favorable cosmetic and clinical results for VSD closure. It provides a good alternative to standard median sternotomy for VSD patients. (Source: The Annals of Thoracic Surgery)

Outcomes Using Predominantly Single-Stage Approach to Interrupted Aortic Arch and Associated Defects [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions A good functional outcome and low reoperation rate can be achieved with a single-stage repair regardless of the presence of major additional cardiac abnormalities. Neonates with risk factors such as low birth weight and prematurity require an individualized approach. (Source: The Annals of Thoracic Surgery)

Successful Staged Fontan Completion for Truncus Arteriosus With Hypoplastic Left Ventricle [CASE REPORTS]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Concomitant Septal Myectomy at the Time of Aortic Valve Replacement for Severe Aortic Stenosis [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:18 +0100

Conclusions A quantitative assessment of the obstructive ABSH in the setting of severe aortic stenosis may be difficult preoperatively. Surgeons should inspect left ventricular outflow tract for possible obstructive ABSH at the time of AVR. Concomitant myectomy is a safe and effective procedure without additional complications and should be considered for patients with a preoperative or intraoperative diagnosis of ABSH even though dynamic obstruction was not demonstrated. (Source: The Annals of Thoracic Surgery)

Acute Ischaemic Ventricular Septal Defect—A Formidable Surgical Challenge

Heart, Lung & Circulation — Tue, 26 Jan 2010 13:54:19 +0100

Conclusions: Acute Ischaemic VSD is a grim surgical disease marked by residual shunts and high mortality. Patients with inferior defects with shock should be offered surgery only under exceptional circumstances. (Source: Heart, Lung & Circulation)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Screening fetal echocardiography in diabetic mothers with normal findings on detailed anatomic survey.

The Ultrasound Review of Obstetrics and Gynecology — Mon, 25 Jan 2010 00:00:00 +0100

CONCLUSIONS: In an environment with access to high-volume, skilled comprehensive ultrasound services, fetal echocardiography by a pediatric cardiology program adds little to the care of women with diabetes and no suspected heart disease on a detailed anatomic survey. Poor acoustic windows frequently necessitate multiple visits. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20101639 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

The Relative Atrial Index (RAI)—A Novel, Simple, Reliable, and Robust Transthoracic Echocardiographic Indicator of Atrial Defects

Journal of the American Society of Echocardiography — Mon, 25 Jan 2010 00:00:00 +0100

Conclusion: The RAI, a novel and simple transthoracic parameter, reliably identifies patients with possible atrial shunting. The resolution of right atrial enlargement occurs remarkably early after percutaneous ASD closure, as demonstrated by this novel parameter. (Source: Journal of the American Society of Echocardiography)

A case of iatrogenic aortic valve leaflet perforation after closure of a ventricular septal defect

The International Journal of Cardiovascular Imaging — Sat, 23 Jan 2010 07:46:22 +0100

This report describes a case of aortic regurgitation that was caused by iatrogenic aortic valve leaflet perforation, and this occurred in a 22-year-old woman who underwent repair of a ventricular septal defect (VSD) 15 years previously. Transthoracic echocardiography (TTE) showed a defect located at the aortic annulus close to the infundibular septum on a two-dimensional echocardiographic study and we observed an eccentric jet flow into the left ventricle in early diastole on the continuous wave and color flow Doppler studies. A small perforation in the body of the right aortic cusp and mild to moderate aortic regurgitation were confirmed by the use of transesophageal echocardiography (TEE) and ascending aortography. Content Type Journal ArticleCategory Case ReportDOI 10.1007/...

Failed closure of a ventricular septal defect with an Amplatzer occluder [Case report - Cardiac general]

Interactive CardioVascular and Thoracic Surgery — Wed, 20 Jan 2010 23:13:42 +0100

A 74-year-old man was diagnosed to have a ventricular septal defect (VSD), which was detected shortly following transvenous pacemaker implantation. Transoesophageal echocardiography suggested the presence of two VSDs, one of which was closed with a device. At surgery, a single large VSD was seen, with the implanted device having embolised into the left ventricle. The defect was successfully closed using a pericardial patch, and the embolised device explanted. (Source: Interactive CardioVascular and Thoracic Surgery)

Right to left shunt following radiofrequency catheter ablation of atrial fibrillation in a patient with complex congenital heart disease

Europace — Wed, 20 Jan 2010 16:18:37 +0100

We report a case of an iatrogenic atrial septal defect following left atrial ablation for persistent atrial fibrillation in a patient with a Fontan circulation. Transseptal puncture was performed with two sheaths across a single puncture and left atrial ablation undertaken. Post procedure the patient became cyanosed with right to left shunting. Transcatheter closure immediately improved symptoms and oxygen saturation. (Source: Europace)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Morphologic, Mechanical, Conductive, and Hemodynamic Changes Following Transcatheter Closure of Atrial Septal Defect

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusions. Transcatheter ASD closure is followed by morphologic, conductive, and hemodynamic changes at different time intervals during the first years and results in normalization or near normalization of the heart's structure and function. (Source: Congenital Heart Disease)

Long-Term Follow Up of Secundum Atrial Septal Defect Closure with the Amplatzer Septal Occluder

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusion. These data indicate that for up to 120 months of patient follow-up, the ASO continues to be a safe device. Residual shunts and arrhythmias have low incidence post-ASO placement. Given the mortality in one high-risk patient, further investigation into anti-platelet therapy after device placement is warranted. (Source: Congenital Heart Disease)

Adults with Down Syndrome: Safety and Long-term Outcome of Cardiac Operation

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusion. At an experienced center, adult patients with Down syndrome can undergo cardiac surgery with a low risk of mortality and acceptable morbidity. Atrial arrhythmias and pulmonary infections are common postoperatively. (Source: Congenital Heart Disease)

Perventricular Closure of a Large Ventricular Septal Defect in Congenitally Corrected Transposition of the Great Arteries

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

We report the case of a 30 year-old male with congenitally corrected transposition of the great arteries, atrial, and ventricular septal defects (VSD), and pulmonary stenosis. He previously underwent three palliative surgical procedures before undergoing intracardiac repair at age 20 with a left ventricular to pulmonary artery (LV-PA) conduit, VSD closure, and replacement of the systemic atrioventricular valve. A residual VSD was noted postoperatively. He did well for approximately 10 years when he started becoming more breathless with daily activities and was noted to have a resting room air oxygen saturation of 85%. Despite increased diuretic therapy he continued to deteriorate and was ultimately admitted to the hospital in florid right and left heart failure with recurrent atrial fibril...

Cryothermal Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia in a Pediatric Patient after Atrioventricular Canal Repair

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

We describe successful cryothermal modification of the slow atrioventricular nodal pathway in a 12-year-old patient with a previously repaired partial atrioventricular septal defect and inducible atrioventricular nodal reentrant tachycardia. The use of a steerable catheter to locate the displaced His signal combined with the use of cryothermal energy allowed for the safe and effective treatment of this patient's tachycardia. (Source: Congenital Heart Disease)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Oral Manifestations in Ellis-van Creveld Syndrome: Report of a Case and Review of the Literature

Journal of Oral and Maxillofacial Surgery — Tue, 19 Jan 2010 14:19:34 +0100

Ellis-van Creveld syndrome (EVC), initially called chondroectodermal dysplasia, was first described in 1940 by the pediatricians Richard Ellis and Simon van Creveld. It is a rare recessive autosomal disorder characterized by chondrodysplasia, postaxial polydactyly, ectodermal dysplasia, and congenital malformations, most frequently an atrioventricular septal defect, which is observed in 60% of patients. Even though these 4 features classically define the syndrome, a variable spectrum of clinical manifestations is often present. (Source: Journal of Oral and Maxillofacial Surgery)

Unicuspid Aortic Valve, Hand AnomaliesA Heart-Hand Syndrome.

The American Journal of the Medical Sciences — Tue, 19 Jan 2010 00:00:00 +0100

Authors: Nanda S, Longo S, Arastu MI Embryonic heart and limb development are closely related with >100 known inherited disorders affecting both. Common limb defects include duplication, deficiencies, and hypoplasia. Ventricular septal defects and atrial septal defects are the commonest associated cardiac conditions. A positive association exists between heart defects and limb disorders when these disorders are analyzed separately. Closer associations exist between heart defects and upper limb defects compared with lower limb defects. The majority of limb defects occur in the more distal parts of the affected limb. Genes expressed in both the heart and limb development include TGF-beta, BMP4, Msx transcription factor, HAND gene, retinoic acid receptor, and sonic hedgehog gene. Radia...

Intermediate-Term Effects of Transcatheter Secundum Atrial Septal Defect Closure on Cardiac Remodeling in Children and Adults

Pediatric Cardiology — Mon, 18 Jan 2010 18:44:04 +0100

Abstract The study aimed to investigate the intermediate-term effects of transcatheter atrial septal defect (ASD) closure on cardiac remodeling in children and adult patients. Between December 2003 and February 2009, 117 patients (48 males, 50 adults) underwent transcatheter ASD closure with the Amplatzer septal occluder (ASO). The mean age of the patients was 15 years, and the mean follow-up period was 25.9 ± 12.4 months. New York Heart Association (NYHA) class, electrocardiographic parameters, and transthoracic echocardiographic (TTE) examination were evaluated before the ASD closure, then 1 day, 1 month, 6 months, 12 months, and yearly afterward. Transcatheter ASD closure was successfully performed for 112 (96%) of the 117 patient...

Pregnancy outcome in patients with complex pulmonary atresia: case report and review of the literature

European Journal of Heart Failure — Mon, 18 Jan 2010 18:16:39 +0100

We report here on the outcome of pregnancy in a woman, aged 36, with complex pulmonary atresia in whom palliative operation had been performed at the age of 23. We review the medical literature on pregnancy course as well as maternal and foetal outcome in cases involving this maternal congenital heart disease. (Source: European Journal of Heart Failure)

Palliative atrial switch operation in a 22-year-old patient with transposition of the great arteries.

The Thoracic and Cardiovascular Surgeon — Sat, 16 Jan 2010 23:16:40 +0100

Authors: Yang HS, Park SY, Park HK, Park YH A 2-year-old boy was diagnosed as having transposition of the great arteries (TGA) and ventricular septal defect (VSD) and underwent pulmonary artery banding. The patient showed slow progression of cyanosis and dyspnea on exertion. Oxygen saturation was 70-75 % and cardiac catheterization showed severe pulmonary hypertension. At the age of 22, the patient underwent a palliative atrial switch operation; oxygen saturation increased to around 95 % and the patient experienced relief of symptoms. Atrial fibrillation and right side pleural effusion occurred but resolved and the patient was discharged. PMID: 20072977 [PubMed - in process] (Source: The Thoracic and Cardiovascular Surgeon)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Altered Cardiac Function and Ventricular Septal Defect in Avian Embryos Exposed to Low-Dose Trichloroethylene

Toxicological Sciences — Fri, 15 Jan 2010 07:59:18 +0100

Trichloroethylene (TCE) is the most frequently reported organic groundwater contaminant in the United States. It is controversial whether gestational TCE exposure causes congenital heart defects. The basis for TCE’s proposed cardiac teratogenicity is not well understood. We previously showed that chick embryos exposed to 8 ppb TCE during cardiac morphogenesis have reduced cardiac output and increased mortality. To further investigate TCE’s cardioteratogenic potential, we exposed in ovo chick embryos to TCE and evaluated the heart thereafter. Significant mortality was observed following TCE exposures of 8–400 ppb during a narrow developmental period (Hamburger-Hamilton [HH] stages 15–20, embryo day ED2.3–3.5) that is characterized by myocardial expansion, secon...

Pearls for Ablation in Congenital Heart Disease

Journal of Cardiovascular Electrophysiology — Fri, 15 Jan 2010 00:00:00 +0100

This article focuses on the technical aspects of catheter ablation of these arrhythmias, due to the challenges presented by the underlying anatomy compared with patients having normal hearts. (J Cardiovasc Electrophysiol, Vol. pp. 1-8) (Source: Journal of Cardiovascular Electrophysiology)

Pancreatic hypoplasia presenting with neonatal diabetes mellitus in association with congenital heart defect and developmental delay

American Journal of Medical Genetics Part A — Fri, 15 Jan 2010 00:00:00 +0100

We report on a series of three patients with pancreatic agenesis and congenital heart defects. All had abdominal scan evidence of pancreatic agenesis. In addition, Patient 1 had a ventricular septal defect, patent ductus arteriosus and pulmonary artery stenosis; Patient 2 had a truncus arteriosus and Patient 3 had tetralogy of Fallot. Two of the three patients have developmental delay. All three patients were isolated cases within the family. Investigations included sequencing of GCK, ABCC8, IPF1, NEUROD1, PTF1A, HNF1B, INS, ISL1, NGN3, HHEX, G6PC2, TCF7L2, SOX4, FOXP3 (Patients 1 and 2), GATA4 and KCNJ11 genes (all three patients), but no mutations were found. Genetic investigation to exclude paternal UPD 6, methylation aberrations and duplications of 6q24 was also negative in all three. ...

Palliative Atrial Switch Operation in a 22-Year-Old Patient with Transposition of the Great Arteries

The Thoracic and Cardiovascular Surgeon — Thu, 14 Jan 2010 16:42:21 +0100

Thorac cardiovasc Surg 2010; 58: 45-47DOI: 10.1055/s-2008-1039232AbstractA 2-year-old boy was diagnosed as having transposition of the great arteries (TGA) and ventricular septal defect (VSD) and underwent pulmonary artery banding. The patient showed slow progression of cyanosis and dyspnea on exertion. Oxygen saturation was 70–75 % and cardiac catheterization showed severe pulmonary hypertension. At the age of 22, the patient underwent a palliative atrial switch operation; oxygen saturation increased to around 95 % and the patient experienced relief of symptoms. Atrial fibrillation and right side pleural effusion occurred but resolved and the patient was discharged.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | ...

Late device thrombosis after atrial septal defect closure

European Heart Journal — Thu, 14 Jan 2010 08:06:40 +0100

(Source: European Heart Journal)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Vegetation With Ventricular Septal Defect Detected by Cardiac Magnetic Resonance Imaging.

Circulation Journal — Thu, 14 Jan 2010 00:00:00 +0100

Authors: Kurita T, Tanabe M, Kitagawa K, Onishi K, Shimpo H, Sakuma H, Ito M PMID: 20075557 [PubMed - as supplied by publisher] (Source: Circulation Journal)

Popliteal pterygium associated with atrial septal defect

European Journal of Orthopaedic Surgery & Traumatology — Mon, 11 Jan 2010 18:20:50 +0100

Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0572-1Authors Hironobu Koseki, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 JapanToshiyuki Tsurumoto, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 JapanHiroyuki Shindo, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 Japan Journal European Journal of Orthopaedic Surgery & TraumatologyOnline ISSN 1432-1068Print ISSN 1633-8065 (Source: European Journal of Orthopaedic Surgery & Traumatology)

Bilateral lung transplantation with closure of ventricular septal defect in a patient with Eisenmenger syndrome

General Thoracic and Cardiovascular Surgery — Fri, 08 Jan 2010 13:53:25 +0100

We report the first case with Eisenmenger syndrome secondary to an isolated perimembranous ventricular septal defect (VSD) in a patient who underwent bilateral lung transplantation and closure of the VSD in Japan. This male patient was diagnosed as having a VSD associated with severe pulmonary hypertension at the age of 7, and right unilateral pulmonary artery banding was performed at age 9. At 38 years of age, we performed bilateral cadaveric lung transplantation with patch closure of the VSD. Explant pathology revealed grade 3 for the right lung and grade 4 for the left lung by the Heath-Edwards classification. The ventricular contractility had gradually improved, and ventricular arrhythmia requiring amiodarone prior to lung transplantation had disappeared. When cardiac function is...

Congenital Left Ventricle-to-Pulmonary Artery Fistula

Journal of the American College of Cardiology — Fri, 08 Jan 2010 13:50:11 +0100

An 11-month-old girl presented with tachypnea and a grade 3/6 systolic heart murmur on her physical examination when receiving a scheduled vaccination. Chest radiography showed cardiomegaly and increased lung markings. Transthoracic color Doppler echocardiography showed a type-2 atrial septal defect and an abnormal turbulent flow from the lateral wall of the left ventricle (LV), but both coronary arteries appeared normal. Cardiac catheterization was performed that revealed 2 oxygen-saturation step-ups, 1 at the right ventricle (from 62% to 85%) and the other at the pulmonary artery (PA) (from 85% to 87%), with a total Qp/Qs of 3.5. An angiogram of the LV showed 2 fistulas originated from the lateral wall of the LV and then joined together to drain into the posterior-lateral side of the PA ...

The Year in Congenital Heart Disease

Journal of the American College of Cardiology — Fri, 08 Jan 2010 13:50:10 +0100

With the increasing number of excellent papers related to congenital heart disease, it has become more difficult to select those that are perceived to be particularly critical to scientific developments in the field. I have chosen in this review to focus almost entirely on results and to follow surgical- or catheter-based interventions that highlight the complex conditions that surgeons and cardiologists now are able to repair or palliate successfully. Sections chosen are tetralogy of Fallot (TOF), Fontan operation, cardiac surgery in general, transposition of the great arteries (TGA), hypoplastic left heart syndrome (HLHS), aortic valve surgery, aortoplasty, and ventricular septal defect (VSD) management. These particular areas were chosen because of the importance to the general field of...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cardiac remodeling and effects on exercise capacity after interventional closure of atrial septal defects in different adult age groups

Clinical Research in Cardiology — Fri, 08 Jan 2010 09:08:53 +0100

Conclusion Patients benefit from interventional closure of hemodynamically significant ASD regardless of their age. However, the defect should be repaired as early as possible to prevent hemodynamic complications, such as the development of pulmonary hypertension and cardiac arrhythmias. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-009-0105-2Authors Smita Jategaonkar, Städt. Klinikum Braunschweig Department of Internal Medicine 2 Braunschweig GermanyWerner Scholtz, Ruhr University Bochum Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia Georgstr. 11 32545 Bad Oeynhausen GermanyHenning Schmidt, Ruhr University Bochum Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia Georgstr. 11 32545 Bad Oeynh...

Congenital malformations in infants born after in vitro fertilization in Sweden

Birth Defects Research Part A: Clinical and Molecular Teratology — Fri, 08 Jan 2010 00:00:00 +0100

The risk for congenital malformations is increased in infants born after in vitro fertilization (IVF). Some specific malformations appear to be more affected than others.The presence of congenital malformations in 15,570 infants born after IVF with an embryo transfer between April 1, 2001, and the end of 2006 were compared with all infants born in Sweden during 2001 to 2007 (n = 689,157). Risk estimates were made after adjusting for year of birth, maternal age, parity, smoking, and body mass index. The risks of specific malformations were compared with data from a previous study (1982 to March 31, 2001) of 16,280 infants born after IVF. Different IVF methods were compared to respect to malformation risk.Increased risks of a similar magnitude were found for most cardiovascular malformations...

Incidence of atrial fibrillation after percutaneous closure of patent foramen ovale and small atrial septal defects in patients presenting with cryptogenic stroke

International Journal of Stroke — Thu, 07 Jan 2010 00:00:00 +0100

The occurrence of atrial fibrillation after percutaneous closure of a patent foramen ovale for cryptogenic stroke has been reported in a variable percentage of patients. However, its precise incidence and mechanism are presently unclear and remain to be elucidated. Prospective follow-up study. Ninety-two patients undergoing a percutaneous patent foramen ovale closure procedure (closure group) for cryptogenic stroke were compared with a similar group of 51 patients, who were medically treated. A systematic arrhythmia follow-up protocol to assess the incidence of AF was performed including a 7-day event-loop recording at day 1, after 6 and 12 months in patients of the closure group and compared with those of the medically treated group. The incidence of AF was similar in both study groups du...

Late Bacterial Endocarditis of an Amplatzer Atrial Septal Defect Occluder Device

The American Journal of Cardiology — Tue, 05 Jan 2010 13:52:39 +0100

In conclusion, the present report is the first description of late infective endocarditis in an adult with an ASO. (Source: The American Journal of Cardiology)

Restrictive ventricular septal defect and critical subaortic stenosis in tetralogy of Fallot

Clinical Research in Cardiology — Tue, 05 Jan 2010 06:46:09 +0100

Conclusion In tetralogy of Fallot, accessory tricuspid valve tissue may obstruct the VSD as well as the left ventricular outflow tract resulting in a life threatening condition in newborns shortly after birth. Content Type Journal ArticleCategory Clinical CorrespondenceDOI 10.1007/s00392-009-0111-4Authors Gunter Kerst, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyRenate Kaulitz, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyLudger Sieverding, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyChristian Apitz, University Children’s Hospital Department of Pediatric Cardiology Hoppe...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Umbilical vein anomaly in fetuses with Down syndrome

Ultrasound in Obstetrics and Gynecology — Tue, 05 Jan 2010 00:00:00 +0100

To describe the prevalence of abnormal umbilical vein (UV) anatomy in fetuses with Down syndrome.This was a retrospective survey covering a 24-month period of fetuses with a genetic diagnosis of Down syndrome following a routine early second-trimester (12-16-week) detailed fetal anomaly scan at a single academic tertiary referral center. In our unit this exam includes fetal umbilicoportal venous system evaluation.During the study period, 37 fetuses were diagnosed with Down syndrome and had a detailed early anatomy scan. In four (11%) the detailed early anomaly scan revealed that the UV was connected to the hepatic portion of the inferior vena cava (IVC) at a position lower than its usual site. Their average gestational age at diagnosis was 13 + 6 (range, 11 + 6 to 15 + 2) weeks. Three of t...

Early timing of surgical intervention in patients with Ebstein's anomaly predicts superior long-term outcome [Original articles]

European Journal of Cardio-Thoracic Surgery — Mon, 04 Jan 2010 16:40:24 +0100

Conclusions: Repair, as opposed to replacement, is feasible in the vast majority of patients presenting with Ebstein's anomaly with a low early mortality rate. Outcome, in terms of survival and freedom from re-operation in the long term is determined by the clinical state at the time of surgery. Therefore, timely operation is warranted before significant cardiomegaly develops and functional status deteriorates. (Source: European Journal of Cardio-Thoracic Surgery)

Fast-track paediatric cardiac surgery: the feasibility and benefits of a protocol for uncomplicated cases [Original articles]

European Journal of Cardio-Thoracic Surgery — Mon, 04 Jan 2010 16:40:24 +0100

Conclusion: A fast-track programme can be implemented safely and effectively if the appropriate support including a step-down ward area is put in place. Greater experience with this type of protocol leads to reductions in the length of hospital stay for children aged over 6 months undergoing uncomplicated open-heart surgery. Fast-track cases should be performed in the morning. (Source: European Journal of Cardio-Thoracic Surgery)

Closure of a coexisting ostium secundum atrial septal defect and patent foramen ovale using a single Amplatzer patent foramen ovale occluder device

Cardiovascular Revascularization Medicine — Fri, 01 Jan 2010 00:00:00 +0100

We report the case of a 59-year-old man with cryptogenic stroke who was found to have both an ostium secundum atrial septal defect and a patent foramen ovale (PFO) by intracardiac echocardiography. Both defects were successfully occluded using a single 35-mm Amplatzer PFO occluder device inserted through the atrial septal defect. (Source: Cardiovascular Revascularization Medicine)

Aorto-Left Atrial Fistula Post-Percutaneous Device ASD Closure

Heart, Lung & Circulation — Fri, 01 Jan 2010 00:00:00 +0100

We describe a case of perforation with intracardiac fistula formation, with an underlying mechanism likely to be similar to the few cases previously described, occurring during medium term follow up after ASD device closure. Appropriate case selection can reduce the incidence of this complication with caution taken in ASD cases with deficient aortic and superior rims. (Source: Heart, Lung & Circulation)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Role of intraoperative echocardiography in surgical correction of the superior sinus venosus atrial septal defect.

Annals of Cardiac Anaesthesia — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Gadhinglajkar S, Sreedhar R, Jayakumar K, Misra M, Ganesh S, Mathew T Superior type of sinus venosus atrial septal defect (SVASD) is invariably associated with the unroofing of right upper pulmonary vein (RUPV). Warden procedure and pericardial patch repair with rerouting of the RUPV are commonly performed operations for the superior SVASD. Both operations involve the risk of obstruction to the flow of superior vena cava or rerouted pulmonary vein in the postoperative period. The sinus venosus defects are well visualized on the transesophageal echocardiography (TEE) because of the proximity of the TEE probe to these structures. We are reporting two cases operated for the superior SVASD with unroofed RUPV, highlighting the intraoperative echocardiographic features before and af...

Abdominal aortic embolization of a figulla atrial septum occluder device, at the level of the celiac axis, after an atrial septal defect closure: hybrid attempt.

Vascular — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Jahrome AKh, Stella PR, Leijdekkers VJ, Guyomi SH, Moll FL A 41-year-old woman was treated with a Figulla (Occlutec, Helsingborg, Sweden) atrial septum occluder device with no intraprocedural complications. Five months later, dislocation of the device in the abdominal aorta was detected. The occluder device was located at the level of the celiac axis, nearly obstructing the entire aorta. Owing to total incorporation of the device, endoluminal retrieval was not possible. Through a medial rotation approach, the device was safely removed. This is a rare complication after endoluminal closure of an atrial septum defect. The retrieval possibilities are discussed. PMID: 20122364 [PubMed - in process] (Source: Vascular)

[Left ventricular non-compaction in an infant with congenital heart defect.]

Kardiologia Polska — Fri, 01 Jan 2010 00:00:00 +0100

We report a case of a child with NCLV and coexisting hemodynamic significant ventricular septal defect. PMID: 20131191 [PubMed - in process] (Source: Kardiologia Polska)

[Percutaneous treatment of Lutembacher syndrome: a case report.]

Turk Kardiyoloji Dernegi arsivi — Fri, 01 Jan 2010 00:00:00 +0100

We present a 49-year-old woman with Lutembacher syndrome. On pretreatment transthoracic echocardiography, planimetric mitral valve area was 1.5 cm(2), maximum diastolic gradient was 17 mmHg, and mean diastolic gradient was 9 mmHg. Combined percutaneous treatment was performed including balloon valvuloplasty for MS and closure of the ASD with the Amplatzer septal occluder. The patient was discharged uneventfully. Transthoracic echocardiography performed a week later showed planimetric mitral valve area as 2.1 cm(2), maximum diastolic gradient as 9 mmHg, and mean diastolic gradient as 4 mmHg. Complete closure of the ASD was achieved. Transcatheter treatment may be an effective alternative to surgery in selected patients with Lutembacher syndrome. PMID: 20215845 [PubMed - in process] (Sou...

Case report Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Intra-aortic balloon counterpulsation is often used in critically ill patients with cardiac disease. Commonly accepted indications for its use include cardiogenic shock and mechanical complications of acute myocardial infarction (e.g. ventricular septal defect). The potential benefits of counterpulsation must be weighed against its possible severe thrombotic and hemorrhagic complications. Here we describe a 72-year old female with interventricular septum rupture complicating the course of acute myocardial infarction, in whom the intra-aortic balloon was used to stabilize the circulation prior to the surgery. Despite anticoagulation she developed a thrombus in the abdominal aorta. The risk – benefit ratio and possible ways to predict the complications are discussed. (Source: Articles ...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

CASE REPORTS: Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Congenital Complete Absence of the Left Pericardium: A Rare Cause of Chest Pain or Pseudo-right Heart Overload

Clinical Cardiology — Wed, 30 Dec 2009 00:00:00 +0100

We report the cases of 3 patients who have been seen in our institution with a diagnosis of total congenital absence of the pericardium. All of them complained of precordial pain; one of them experienced disabling symptoms that justified surgical intervention. All of them had previously been suspected to have an atrial septal defect because of the echocardiographic appearance of right ventricular volume overload. Electrocardiogram, chest x-ray, echocardiography, and magnetic resonance imaging of the heart consistently showed remarkably similar features including leftward displacement, increased mobility, and interposition of lung tissue between the heart and other intrathoracic structures.Congenital absence of the left pericardium should be known by clinicians as a possible differential di...

22q11.2 Microdeletion in a Fetus With Double-outlet Right Ventricle, Pulmonary Stenosis and a Ventricular Septal Defect: Prenatal Diagnosis by Array Comparative Genomic Hybridization

Taiwanese Journal of Obstetrics and Gynecology — Mon, 28 Dec 2009 14:44:34 +0100

No abstract (Source: Taiwanese Journal of Obstetrics and Gynecology)

Clinical value of stereoscopic three-dimensional echocardiography in assessment of atrial septal defects: Feasibility and efficiency

Journal of Huazhong University of Science and Technology -- Medical Sciences -- — Mon, 28 Dec 2009 06:42:29 +0100

Summary Stereoscopic three-dimensional echocardiography(S-3DE) is a novel displaying technology based on real-time 3-dimensional echocardiography (RT-3DE). Our study was to evaluate the feasibility and efficiency of S-3DE in the diagnosis of atrial septal defect (ASD) and its use in the guidance for transcatheter ASD occlusion. Twelve patients with secundum ASD underwent RT-3DE examination and 9 of the 12 were subjected to transcatheter closure of ASD. Stereoscopic vision was generated with a high-performance volume renderer with red-green stereoscopic glasses. S-3DE was compared with standard RT-3D display for the assessment of the shape, size, and the surrounding tissues of ASD and for the guidance of ASD occlusion. The appearance rate of coronary sinus and the mean form...

Prenatal double aortic arch presenting with a right aortic arch and an anomalous artery arising from the ascending aorta

The International Journal of Cardiovascular Imaging — Wed, 23 Dec 2009 22:57:21 +0100

We report here on three fetal cases of double aortic arch and their outcomes. These malformations presented as an isolated right aortic arch or as a typical vascular ring form on the prenatal echocardiography that was obtained between 22 and 24 weeks gestation. In two of the three patients, the major intracardiac anomaly was a ventricular septal defect, and this was associated with the aortic malformation. A more detailed evaluation of the branching pattern of the aorta, and particularly whether the aorta gives off a left-sided limb of the double arch, could suggest the diagnosis of a double aortic arch in utero. Two patients underwent successful surgical correction and they showed good clinical outcomes. Fetal double aortic arch can be prenatally suspected after performing feta...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cardiopulmonary bypass flow rate: A risk factor for hyperlactatemia after surgical repair of secundum atrial septal defect in children

The Journal of Thoracic and Cardiovascular Surgery — Wed, 23 Dec 2009 16:15:28 +0100

Conclusion: Lower weight-indexed cardiopulmonary bypass flow rate is an independent risk factor for early postoperative hyperlactatemia in children after atrial septal defect repair. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Behavior of Unrepaired Perimembranous Ventricular Septal Defect in Young Adults

The American Journal of Cardiology — Wed, 23 Dec 2009 00:00:00 +0100

In conclusion, mid-term follow-up of adolescents and young adults with a small and unrepaired pmVSD was not uneventful. Some patients required intervention, but in others, spontaneous closure occurred. Electrocardiographic and structural changes were noticed, for which the clinical significance needs to be determined. (Source: The American Journal of Cardiology)

Role of 64-MDCT in Evaluation of Pulmonary Atresia With Ventricular Septal Defect

American Journal of Roentgenology — Tue, 22 Dec 2009 19:02:37 +0100

CONCLUSION. The management of this complex condition has been largely determined by the morphology of pulmonary arteries and the extracardiac sources of pulmonary blood supply. Although echocardiography and catheter angiography are the traditional imaging techniques used to diagnose PA-VSD, 64-MDCT has become a valuable noninvasive imaging technique in comprehensive evaluation of this condition. (Source: American Journal of Roentgenology)

Nigeria: Saraki's Wife Gives Hole in Heart Child N.4 Million

AllAfrica News: Health and Medicine — Mon, 21 Dec 2009 09:06:03 +0100

Alaafia Kwara, a non-governmental organisation (NGO) of the wife of the Kwara State governor, Mrs. Oluwatoyin Saraki, has donated N400,000 out of N2.5 million for the treatment of a 19-month-old Agachukwu Ovu, who was diagnosed with a hole in the heart. (Source: AllAfrica News: Health and Medicine)

Surgical Revision After Percutaneous Mitral Repair With the MitraClip Device [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

Conclusions Standard surgical options were preserved in patients who had surgery after percutaneous repair with the MitraClip device. Successful repair was feasible in the majority of patients after the MitraClip procedure, with repair performed as late as 18 months after clip implantation. (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Performance of Hancock Porcine-Valved Dacron Conduit for Right Ventricular Outflow Tract Reconstruction [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

Conclusions The Hancock valved conduit is a safe and reliable alternative to homografts. It appears to be appropriate in patients with limited pulmonary vascular bed and high pulmonary artery pressures. Caution is required in neonates because of the rigidity of the Dacron housing. Initial results with secondary percutaneous procedures are encouraging. (Source: The Annals of Thoracic Surgery)

Late Reoperation After Reimplantation of an Anomalous Single Coronary Artery From the Pulmonary Artery [CASE REPORTS]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

A 14-year-old girl with an anomalous origin of a single coronary artery from the pulmonary artery, moderate mitral insufficiency, and an outlet ventricular septal defect, underwent direct reimplantation of the single coronary artery (SCA) to the aorta and closure of the ventricular septal defect at 6 months of age. She had stenosis of the proximal single coronary artery develop 14 years after the initial operation. A patch augmentation of her proximal SCA was successfully performed, and a postoperative coronary angiographic scan taken 3 months after her surgery showed a widely patent SCA without any residual narrowing. (Source: The Annals of Thoracic Surgery)

Chronic Intermittent Materno-Fetal Hyperoxygenation in Late Gestation May Improve on Hypoplastic Cardiovascular Structures Associated with Cardiac Malformations in Human Fetuses

Pediatric Cardiology — Fri, 18 Dec 2009 18:20:24 +0100

Abstract Hypoplasia of cardiovascular structures is a common finding in fetuses with cardiac malformations. Materno-fetal hyperoxygenation (HO) during late gestation promotes venous return to the fetal heart. This analysis in human fetuses sought to define whether this “loading” effect might improve hypoplastic cardiovascular dimensions. Fifteen late-gestation fetuses presented with varying degrees of hypoplastic cardiovascular structures. In these cases, chronic intermittent materno-fetal HO was administered during periods ranging from 8 to 33 days. Cardiac measurements were taken before and at the end of treatment and translated into Z-scores as well as plotted on normal growth charts. During the treatment period, chronic intermittent materno-fetal HO was associ...

New Gene Linked To Congenital Heart Defects

Health News from Medical News Today — Fri, 18 Dec 2009 08:00:00 +0100

Researchers from the UC San Diego, School of Medicine and colleagues have identified a new gene, ETS-1, that is linked to human congenital heart defects. The landmark study, recently published online in the journal of Human Molecular Genetics, provides important insights into some of the most prevalent forms of congenital heart defects in humans, including ventricular septal defects and potentially hypoplastic left heart syndrome, a uniformly fatal heart abnormality... (Source: Health News from Medical News Today)

Right or left anterolateral minithoracotomy for repair of congenital ventricular septal defects in adult patients [Institutional report - Congenital]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

For most patients who present with ventricular septal defects (VSDs) in adulthood, the major concern is not the mortality or morbidity associated with repair surgery, but rather cosmetic problems arising from surgical scarring as a result of median sternotomy. From March 2005 to August 2008, nine patients (M:F=1:8) underwent repair of congenital VSD using right (n=7) or left (n=2) anterolateral minithoracotomy. We compared the perioperative data of these patients with that of the patients (n=8) who underwent VSD repair using median sternotomy during the same period. VSDs were of the perimembranous (n=6), subarterial (n=1), muscular inlet (n=1), and muscular outlet (n=1) type in minithoracotomy group. There was no in-hospital mortality in both groups. Mean cardiopulmonary bypass (CPB) time ...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

eComment: Re: Right or left anterolateral minithoracotomy for repair of congenital ventricular septal defects in adult patients [eComment]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

(Source: Interactive CardioVascular and Thoracic Surgery)

eComment: A limited antero-lateral minithoracotomy for congenital ventricular septal defects repair in adult patients [eComment]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

(Source: Interactive CardioVascular and Thoracic Surgery)

Atrial septal defect (ASD): Readily treatable heart defect

MayoClinic.com Full Feed — Thu, 17 Dec 2009 06:00:00 +0100

Atrial septal defect (ASD) — Comprehensive overview covers symptoms, causes, treatment of this common heart defect. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

Echocardiographic Detection of Atrial Septal Defects: The Forgotten View

Echocardiography — Thu, 17 Dec 2009 00:00:00 +0100

We describe two cases in which the right parasternal view was helpful in assessment of the interatrial septum and the detection of atrial septal defects (ASD), including one case in which this view confirmed the presence of a defect not seen in any other echocardiographic view. Use of the right parasternal view should be considered for assessment of the interatrial septum, particularly when there is a high index of suspicion for an atrial septal defect but no defect is seen on conventional views. It should also be used to exclude the possibility of multiple defects even when an ASD is visualized using conventional imaging planes. (ECHOCARDIOGRAPHY, Volume **, ************) (Source: Echocardiography)

Electroanatomic Relationships in Patients With Primum Atrioventricular Septal Defect

Journal of the American College of Cardiology: Cardiovascular Imaging — Mon, 14 Dec 2009 22:01:29 +0100

Conclusions Abnormality in the position of the papillary muscles changes continuously with the abnormality of the QRS axis. Understanding the electroanatomic relationships provides important insight into developmental relationships between the conduction system and the trabecular structures in primum AVSD patients. These results may provide insights in understanding the continuity of primum AVSD abnormality, in estimating the best surgical approach, and predicting the prognosis of primum AVSD patients. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Atrioventricular septal defect with tetralogy of Fallot in patient with Down's syndrome

Revista Brasileira de Cirurgia Cardiovascular — Sat, 12 Dec 2009 16:02:07 +0100

We present a case of a 44-year-old man with prosthetic aortic endocarditis complicated by a perivalvular abscess. He evolved with improvement of the infectious process only under clinical treatment. The patient presented a prior history of rheumatic fever and had previously been undergone three valve replacements due to prosthesis dysfunction and previous endocarditis. In this case report we discuss the main features of perivalvular abscess complicating infective endocarditis (Source: Revista Brasileira de Cirurgia Cardiovascular)

Endoscopic treatment of tracheobronchial tree fistulas using atrial septal defect occluders: preliminary results

Jornal Brasileiro de Pneumologia — Sat, 12 Dec 2009 15:06:49 +0100

We report the cases of three patients submitted to endoscopic closure of fistulas, two of which were larger than 10 mm in diameter, by means of the insertion of atrial septal defect occluders. The procedure was minimally invasive, and the initial results were positive. The results indicate that this is a promising technique for the resolution of tracheobronchial tree fistulas. (Source: Jornal Brasileiro de Pneumologia)

Distal femoral duplication and fibular agenesis associated with congenital cardiac defect

Indian Journal of Pediatrics — Sat, 12 Dec 2009 14:30:38 +0100

We report a newborn, who had the congenital anomalies including protuberance on the right lower leg, bilateral equinovarus deformity of the feet, genu valgum with knee flexion deformity, syndactyly between the first and the second digit on the right, in addition with the absence of the fifth digit. Echocardiography revealed a secundum type atrial septal defect. The combination of these congenital defects associated with developmental anomalies of lower extremities. We discuss the clinical, radiological findings and pathogenesis of this lower extremity malformation. Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-009-0228-5Authors Murat Cakir, Karadeniz Technical University Faculty of Medicine, Department of Pediatrics Trabzon TurkeyLies H. Hoefsloot, Radboud ...

Emergency balloon dilation or stenting of critical coarctation of aorta in newborns and infants: An effective interim palliation

Annals of Pediatric Cardiology — Sat, 12 Dec 2009 13:50:44 +0100

Conclusion</b> : Balloon dilation &#177; stenting is an effective interim palliation for infants and newborns with critical coarctation and LV dysfunction. Restenosis is inevitable and requires to be addressed. (Source: Annals of Pediatric Cardiology)

Radiofrequency ablation in an infant with recurrent supraventricular tachycardia and cyanosis

Annals of Pediatric Cardiology — Sat, 12 Dec 2009 13:50:44 +0100

We report an unusual presentation of supraventricular tachycardia, in an infant, with cyanosis. The child had atrial septal defect with hypoplastic right ventricle. Radiofrequency ablation was performed in view of drug resistant SVT (Source: Annals of Pediatric Cardiology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Molecular genetics of congenital atrial septal defects

Clinical Research in Cardiology — Fri, 11 Dec 2009 06:52:17 +0100

Abstract Congenital heart defects (CHD) are the most common developmental errors in humans, affecting 8 out of 1,000 newborns. Clinical diagnosis and treatment of CHD has dramatically improved in the last decades. Hence, the majority of CHD patients are now reaching reproductive age. While the risk of familial recurrence has been evaluated in various population studies, little is known about the genetic pathogenesis of CHD. In recent years significant progress has been made in uncovering genetic processes during cardiac development. Data from human genetic studies in CHD patients indicate that the genetic aetiology was presumably underestimated in the past. Inherited mutations in genes encoding cardiac transcription factors and sarcomeric proteins were found as an underlyi...

Nigeria: Hole-in-the Heart Boy Needs N2 Million to Live

AllAfrica News: Health and Medicine — Mon, 07 Dec 2009 10:33:40 +0100

He was just a month old when his parents started noticing some symptoms of a health problem in him but it was not until eight months later that it was discovered that the little Aghachukwu Ovu is suffering from tetralogy of fallot, a disease of a hole in the heart. (Source: AllAfrica News: Health and Medicine)

Usefulness of Early Diastolic Mitral Annular Velocity to Predict Plasma Levels of Brain Natriuretic Peptide and Transient Heart Failure Development After Device Closure of Atrial Septal Defect

The American Journal of Cardiology — Sun, 06 Dec 2009 13:50:16 +0100

This study tested the hypothesis that the underlying diastolic dysfunction, assessed on tissue Doppler images (TDI) before device closure, can predict BNP level after ASD closure. The study subjects were 39 consecutive patients (age 27.5 ± 16.3 years, range 5 to 63) who underwent device closure for ASD. Echocardiographic evaluation using TDI and 2-dimensional and pulse wave Doppler were performed, together with plasma BNP measurement 1 day before and 2 days after ASD closure. Before ASD closure, an age-dependent decrease was noted in left ventricular relaxation, assessed by early diastolic mitral annular velocity. ASD closure resulted in a decrease in early diastolic mitral annular velocity (from 14.7 to 12.3 cm/s, p (Source: The American Journal of Cardiology)

Left atrial myxoma with an atrial septal defect.

Cardiology Journal — Thu, 03 Dec 2009 17:14:03 +0100

Authors: Jegier B, Jaszewski R, Lelonek M In a 62-year old woman with arterial hypertension, a left atrial myxoma and a concomitant atrial septal defect, diagnosed intraoperatively, were recognized. The atrial septal defect was not observed pre-operatively by transthoracic and transoesophageal echocardiography with color Doppler. The myxoma was pedunculated and situated on the inferior part of the interatrial septum and moved to the left ventricle in the diastolic phase. The histopathologic finding was consistent with the diagnosis of myxoma. PMID: 19950097 [PubMed - in process] (Source: Cardiology Journal)

Electrophysiologic and anatomical relationships studied in primum atrioventricular septal defect

Journal of Electrocardiology — Thu, 03 Dec 2009 00:00:00 +0100

This article presents a review of the anatomical and electrophysiologic characteristics of patients with primum AVSD and provides recent knowledge of electroanatomical relationships of the heart. (Source: Journal of Electrocardiology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The utility of modified Butler-Leggett criteria for right ventricular hypertrophy in detection of clinically significant shunt ratio in ostium secundum–type atrial septal defect in adults

Journal of Electrocardiology — Thu, 03 Dec 2009 00:00:00 +0100

This study was performed to test the hypothesis that there exists a correlation between the Butler-Leggett (BL) criterion for right ventricular hypertrophy on the electrocardiogram and the Qp/Qs shunt ratio in adults with ostium secundum atrial septal defects (ASDs).Methods: Demographic, cardiac catheterization, ASD closure, and electrocardiographic data were acquired on 70 patients with secundum ASDs closed percutaneously. Simple linear regression and logistic regression models were created to test the hypothesis.Results: The mean Qp/Qs ratio and BL criterion value were 1.61 ± 0.46 and 0.11 ± 0.41, respectively. The BL criterion values correlated with shunt ratios (r2 = 0.11 and P = .004). A BL criterion value greater than 0 mV predicted a significant shunt ratio (Qp/Qs ≥1.5) (odds ra...

Idiopathic twin aneurysm of right pulmonary artery diagnosed in a case 17 years after a successful surgical repair of ventricular septal defect.

Anadolu Kardiyol Der... — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Ozbek C, Yetkin U, Yürekli I, Gürbüz A PMID: 19965331 [PubMed - in process] (Source: Anadolu Kardiyol Der...)

The oxidative state of children with cyanotic and acyanotic congenital heart disease.

Anadolu Kardiyol Der... — Tue, 01 Dec 2009 00:00:00 +0100

CONCLUSION: The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar. PMID: 19965321 [PubMed - in process] (Source: Anadolu Kardiyol Der...)

A Family Health Question: What About Dad?

Journal of Men's Health — Tue, 01 Dec 2009 00:00:00 +0100

Men's health may be considered a vital but often overlooked aspect of family health. The health status of adult males has often been dismissed as irrelevant to the well-being of the family. However, the family is built on highly interactive relationships such that the health challenges facing fathers frequently have widespread and demonstrable negative effects on the health of the family as a whole. Following widowhood or disability of a husband, a family may face the loss of a long term companion and considerable bereavement, as well as a difficult burden of care for the disabled person. Surviving spouses face an increased risk of dying over the course of the next year. In disability, a family is likely to face increased health care expense in the face of diminished earnings. Poverty is s...

Spectrum of congenital heart diseases in Kashmir, India.

Indian Pediatrics — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Ashraf M, Chowdhary J, Khajuria K, Reyaz AM A retrospective analysis of case-records data of 53,653 patients (0-18 years) over a two and half year period was conducted to ascertain the spectrum of congenital heart diseases. Two hundred and twenty one patients were found having congenital heart diseases; a prevalence of 4.1/1000. Ventricular septal defect (VSD) was the most frequent lesion seen in 69 (31.2%), followed by patent ductus arteriosus (PDA) in 36 (16.3%) children. Tetralogy of Fallot (TOF) was the most frequent cyanotic heart disease seen in 17 (7.8%) patients. PMID: 20061593 [PubMed - in process] (Source: Indian Pediatrics)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Med Sci Monit 2009; 15(12):CR612-617 "Transcatheter closure as an alternative and equivalent method to the surgical treatment of atrial septal defect in adults: Comparison of early and late results"

Medical Science Monitor — Mon, 30 Nov 2009 15:38:22 +0100

Conclusions: As surgical and device closure appear similarly effective in adults with ASD, avoidance of thoracotomy and cardiopulmonary bypass, in conjunction with a shorter hospital stay, argues in favour of device closure in selected patients. (Source: Medical Science Monitor)

Images of persistent left superior vena cava draining directly into left atrium and secundum-type atrial septal defect

Journal of Cardiovascular Computed Tomography — Mon, 30 Nov 2009 00:00:00 +0100

Abstract: The images of persistent left superior vena cava with the absence of the right superior vena cava are presented in a patient with the diagnosis of secundum-type atrial septal defect. (Source: Journal of Cardiovascular Computed Tomography)

Tetralogy of Fallot: Yesterday and Today

World Journal of Surgery — Sun, 29 Nov 2009 09:38:24 +0100

This article presents a review of TOF, including the history of surgical treatment, present-day approaches, and long-term outcomes. Content Type Journal ArticleDOI 10.1007/s00268-009-0296-8Authors Joanne P. Starr, University of Medicine and Dentistry of New Jersey Department of Surgery Newark NJ 07103 USA Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

Coarctation of the Aorta: Midterm Outcomes of Resection With Extended End-to-End Anastomosis.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:18 +0100

CONCLUSIONS: Repair of coarctation of the aorta with resection with extended end-to-end anastomosis has a low early mortality, effectively addresses transverse arch hypoplasia, and at midterm follow-up has a low rate of reintervention for recurrent coarctation. PMID: 19932265 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Arterial switch for transposition of the great vessels and taussig-bing anomaly after six months of age.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:11 +0100

CONCLUSIONS: Arterial switch operation shows satisfactory operative outcome of transposition of the great arteries plus ventricular septal defect or Taussig-Bing anomaly in children older than the age of 6 months with moderate-to-severe pulmonary hypertension. PMID: 19932267 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Early and intermediate outcome after anatomic repair of congenitally corrected transposition of the great arteries.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:08 +0100

CONCLUSIONS: Senning/arterial switch operations can be performed with excellent intermediate-term outcomes in patients with lesions previously thought to confer higher risk. Candidates for Senning/Rastelli procedures may be at increased risk for postoperative morbidity and mortality. More data are necessary to determine factors influencing outcome after anatomic repair. PMID: 19932268 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Metal allergy to amplatzer occluder device presented as severe bronchospasm.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:07:16 +0100

We report a case of severe bronchospasm secondary to a metal allergy after an atrial septal defect device closure requiring device removal. PMID: 19932286 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Tricuspid and aortic valve and ventricular septal defect endocarditis: an unusual presentation of acute q Fever.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:07:04 +0100

We report a case of Q fever endocarditis involving the tricuspid and aortic valves and a congenital ventricular septal defect. Surgical treatment and distinct aspects of this unusual case are herein described. PMID: 19932290 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Prenatal diagnosis of left atrial isomerism

Heart — Fri, 27 Nov 2009 18:01:44 +0100

Conclusion: Left atrial isomerism presents a varied spectrum of cardiac malformations when it is detected prenatally. Complete heart block, complex cardiac abnormalities and fetal hydrops are poor prognostic features. Those with only minor cardiac malformations are at risk postnatally for biliary atresia and for bowel obstruction due to malrotation. (Source: Heart)