MedWorm: Hole in the Heart

Rudhe syndrome: reversible right middle lobe emphysema in infants with left-to-right shunts—an historical review

Pediatric Radiology — Fri, 05 Feb 2010 08:33:56 +0100

Abstract In 1971, the Swedish radiologist Ulf Rudhe wrote a provocative paper on right middle lobe emphysema in infants with left-to-right shunts in which he suggested cardiac surgery rather than lung resection. At the time, this was counter to accepted medical practice. Earlier diagnosis and better medical management of ventricular septal defect in infants has proved Rudhe correct. However, two current cases of large left-to-right shunts in infants with emphysema of the right middle lobe prompt this historical review of what seemed a closed-episode in pediatric cardiac surgery. Content Type Journal ArticleCategory Historical PerspectiveDOI 10.1007/s00247-009-1530-0Authors Lee K. Collins, Schneiders Children’s Hospital Department of Radiology Manhasset NY USATerry L. ...

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Percutaneous successful closure of dual atrial septal defect with two Amplatzer septal occluder devices

Clinical Research in Cardiology — Wed, 03 Feb 2010 17:55:26 +0100

We report a case of percutaneous dual atrial septal defect closure with two Amplatzer septal occluder devices. Content Type Journal ArticleCategory Clinical CorrespondenceDOI 10.1007/s00392-010-0124-zAuthors Hamza Duygu, Ataturk Training and Research Hospital Izmir TurkeyHalit Acet, Ataturk Training and Research Hospital Izmir TurkeyUgur Kocabas, Ataturk Training and Research Hospital Izmir TurkeyZehra Ilke Akyildiz, Ataturk Training and Research Hospital Izmir TurkeyCem Nazli, Ataturk Training and Research Hospital Izmir TurkeyOktay Ergene, Ataturk Training and Research Hospital Izmir Turkey Journal Clinical Research in CardiologyOnline ISSN 1861-0692Print ISSN 1861-0684 (Source: Clinical Research in Cardiology)

Right Ventricular Function Suffers From Reperfusion Delay: Tissue Doppler Study

Clinical Cardiology — Tue, 02 Feb 2010 00:00:00 +0100

In this study, impact of reperfusion delay on adverse cardiac events and right ventricular (RV) function in patients with acute right ventricular myocardial infarction (RVMI) was assessed. In 70 patients with RVMI, RV function was assessed by M-mode tricuspid annular plane systolic excursion (TAPSE) and by pulsed wave tissue Doppler echocardiography (TDE). Right ventricular early (E[prime]T) and late diastolic (A[prime]T), peak systolic tricuspid annular velocity, (S[prime]T) and right ventricular myocardial performance index (RVMPI) were measured. Patients were divided into 2 groups according to the time between the onset of symptoms and percutaneous transluminal coronary angioplasty (PTCA) - group 1 (n = 25), [le]3 hours and group 2 (n = 45), > 3 hours. During 30-day follow-up, we assess...

Brain Abscess in an Adult With Atrial Septal Defect

Clinical Cardiology — Tue, 02 Feb 2010 00:00:00 +0100

This article describes the case of a 41-year-old man who presented with altered mental status. Brain MRI showed a brain abscess at the left frontal lobe. The patient was successfully treated with surgical removal and appropriate antibiotics. Echocardiographic examination showed atrial septal defect (ASD) with bidirectional shunt. Transcatheter closure of ASD was carried out 6 months after neurosurgical treatment. We discuss the association of brain abscess and ASD. Copyright © 2009 Wiley Periodicals, Inc. (Source: Clinical Cardiology)

Cardiac malformations and alteration of TGF[beta] signaling system in diabetic embryopathy

Birth Defects Research Part B: Developmental and Reproductive Toxicology — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: Maternal diabetes causes malformations in the heart of the embryo. The heart is more susceptible to maternal diabetic insults than the neural tube. Malformations in the heart prior to septation are associated with decreased cell proliferation, but not increased apoptosis. The TGF[beta] signaling is involved in cardiac malformations in diabetic embryopathy. Birth Defects Res (Part B) XX:1-9, 2010. © 2010 Wiley-Liss, Inc. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)

Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model.

Circulation — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions-Under real-time ultrasound guidance, atrial septal defects were successfully created with extracardiac histotripsy in a live canine model. Although further studies in an intact animal model are needed, these results provide promise of histotripsy becoming a valuable clinical tool. PMID: 20124126 [PubMed - as supplied by publisher] (Source: Circulation)

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Residual atrial septal defect after percutaneous closure with an Amplatzer device [Images in cardio-thoracic surgery]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:37 +0100

(Source: European Journal of Cardio-Thoracic Surgery)

Long-term results after mitral valve repair in children [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: MV repair in children showed excellent survival, acceptable re-operation rate and satisfactory valve function at long-term follow-up. Residual MV dysfunction was a significant risk factor for re-operation, but re-repair was successful in more than half of the patients who underwent re-operation. (Source: European Journal of Cardio-Thoracic Surgery)

Re-repair of the left atrioventricular valve in atrioventricular septal defects: the morphologic approach to the role of Gore-tex band reduction annuloplasty [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Left atrioventricular valve incompetence following previous repair usually involves repair of the zone of apposition between the left bridging leaflets. Many of these valves also require annuloplasty to attain competence. Given the shape, growth potential and morphologic composition of the annulus in these cases, we have performed some of these repairs with a partial flexible ring from a thin-walled 3.5-mm Gore-Tex graft as a reduction annuloplasty that can be shaped to fit the exact contours of this annulus. (Source: European Journal of Cardio-Thoracic Surgery)

Ross and Yasui operations for complex biventricular repair in infants with critical left ventricular outflow tract obstruction [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Case selection is key for complex biventricular repair and the importance of appropriate case selection is exaggerated at young ages. All available options should be considered before pursuing the Ross operation in the presence of co-existing functional morphological abnormalities or emergent iatrogenic aortic regurgitation. However, both the Ross and Yasui operations in children (including neonates and young infants) with favourable functional morphology offer good survival, at least matching that of other biventricular repair strategies. (Source: European Journal of Cardio-Thoracic Surgery)

Dilatable pulmonary artery banding in infants with low birth weight or complex congenital heart disease allows avoidance or postponement of subsequent surgery [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 28 Jan 2010 19:40:36 +0100

Conclusions: Dilation of both main and bilateral branch pulmonary artery bands is possible, effective and safe. Dilatable main pulmonary artery bands allow for progressive dilation with postponement of surgery or complete release of the bands. Bilateral dilatable branch pulmonary bands offer palliative benefit, especially in hybrid cases where pulmonary blood flow may be limited by the bands before the ideal conditions for a stage II procedure exist. (Source: European Journal of Cardio-Thoracic Surgery)

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Totally endoscopic closure of an atrial septal defect using the da vinci surgical system: Report of four cases

Surgery Today — Wed, 27 Jan 2010 20:05:42 +0100

This report presents four cases of totally endoscopic closure of an atrial septal defect using the da Vinci Surgical System (Intuitive Surgical, Mountain View, CA, USA). The patients were diagnosed with an ostium secundum atrial septal defect and elected to undergo minimally invasive surgery. A cardiopulmonary bypass was established via cannulation of the femoral vessel and jugular vein, and blood cardioplegic arrest was induced using a transthoracic cross-clamp. The mean extracorporeal circulation and cardiac arrest times were 86 ± 21 and 22 ± 8 min, respectively. No patient experienced pain after surgery, and all were fast-tracked for early discharge and released on postoperative day 3. No intraoperative or postoperative complications occurred. This procedure permitted a short ho...

Partial and Transitional Atrioventricular Septal Defect Outcomes [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Surgical repair for partial/transitional AVSD is associated with low morbidity and mortality, short hospital stays, and catch-up growth, particularly in underweight children repaired between 3 and 18 months of age. Left atrioventricular valve regurgitation remains the most common residual defect, occurring more frequently in children repaired after 4 years of age. (Source: The Annals of Thoracic Surgery)

Biventricular Repair of Atrioventricular Septal Defect With Common Atrioventricular Valve and Double-Outlet Right Ventricle [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Although technically challenging, the surgical repair can be accomplished with acceptable early results. Heterotaxy syndrome, with concurrent anomalous connections of the pulmonary veins, represented the strongest identified risk factor for death or significant complication. (Source: The Annals of Thoracic Surgery)

Current Expectations for Surgical Repair of Isolated Ventricular Septal Defects [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions Surgical closure of isolated VSD is a safe, effective therapy. Risk of death, complete heart block, and reoperation is minimal. As new technologies for VSD closure evolve, results such as these should be considered when evaluating patients, choosing therapeutic options, and counseling families. (Source: The Annals of Thoracic Surgery)

Ventricular Septal Defects Closure Using a Minimal Right Vertical Infraaxillary Thoracotomy: Seven-Year Experience in 274 Patients [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions The RVIAT can be performed with favorable cosmetic and clinical results for VSD closure. It provides a good alternative to standard median sternotomy for VSD patients. (Source: The Annals of Thoracic Surgery)

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Outcomes Using Predominantly Single-Stage Approach to Interrupted Aortic Arch and Associated Defects [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

Conclusions A good functional outcome and low reoperation rate can be achieved with a single-stage repair regardless of the presence of major additional cardiac abnormalities. Neonates with risk factors such as low birth weight and prematurity require an individualized approach. (Source: The Annals of Thoracic Surgery)

Successful Staged Fontan Completion for Truncus Arteriosus With Hypoplastic Left Ventricle [CASE REPORTS]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:19 +0100

We report a case of truncus arteriosus type II with a large outlet ventricular septal defect and a hypoplastic left ventricle. The first-stage palliation was the removal of both branch pulmonary arteries from the ascending aorta, patch augmentation of the pulmonary artery confluence, and modified Blalock-Taussig shunt at age 1 month. The second stage palliation was a bidirectional Glenn at 6 months. The final stage was an extracardiac Fontan at age 3 years. Eight years later, the patient is doing well, with an unobstructed Fontan pathway and mild-to-moderate truncal valve insufficiency. (Source: The Annals of Thoracic Surgery)

Concomitant Septal Myectomy at the Time of Aortic Valve Replacement for Severe Aortic Stenosis [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Wed, 27 Jan 2010 19:27:18 +0100

Conclusions A quantitative assessment of the obstructive ABSH in the setting of severe aortic stenosis may be difficult preoperatively. Surgeons should inspect left ventricular outflow tract for possible obstructive ABSH at the time of AVR. Concomitant myectomy is a safe and effective procedure without additional complications and should be considered for patients with a preoperative or intraoperative diagnosis of ABSH even though dynamic obstruction was not demonstrated. (Source: The Annals of Thoracic Surgery)

Acute Ischaemic Ventricular Septal Defect—A Formidable Surgical Challenge

Heart, Lung & Circulation — Tue, 26 Jan 2010 13:54:19 +0100

Conclusions: Acute Ischaemic VSD is a grim surgical disease marked by residual shunts and high mortality. Patients with inferior defects with shock should be offered surgery only under exceptional circumstances. (Source: Heart, Lung & Circulation)

Screening fetal echocardiography in diabetic mothers with normal findings on detailed anatomic survey.

The Ultrasound Review of Obstetrics and Gynecology — Mon, 25 Jan 2010 00:00:00 +0100

CONCLUSIONS: In an environment with access to high-volume, skilled comprehensive ultrasound services, fetal echocardiography by a pediatric cardiology program adds little to the care of women with diabetes and no suspected heart disease on a detailed anatomic survey. Poor acoustic windows frequently necessitate multiple visits. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20101639 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

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A case of iatrogenic aortic valve leaflet perforation after closure of a ventricular septal defect

The International Journal of Cardiovascular Imaging — Sat, 23 Jan 2010 07:46:22 +0100

This report describes a case of aortic regurgitation that was caused by iatrogenic aortic valve leaflet perforation, and this occurred in a 22-year-old woman who underwent repair of a ventricular septal defect (VSD) 15 years previously. Transthoracic echocardiography (TTE) showed a defect located at the aortic annulus close to the infundibular septum on a two-dimensional echocardiographic study and we observed an eccentric jet flow into the left ventricle in early diastole on the continuous wave and color flow Doppler studies. A small perforation in the body of the right aortic cusp and mild to moderate aortic regurgitation were confirmed by the use of transesophageal echocardiography (TEE) and ascending aortography. Content Type Journal ArticleCategory Case ReportDOI 10.1007/...

Failed closure of a ventricular septal defect with an Amplatzer occluder [Case report - Cardiac general]

Interactive CardioVascular and Thoracic Surgery — Wed, 20 Jan 2010 23:13:42 +0100

A 74-year-old man was diagnosed to have a ventricular septal defect (VSD), which was detected shortly following transvenous pacemaker implantation. Transoesophageal echocardiography suggested the presence of two VSDs, one of which was closed with a device. At surgery, a single large VSD was seen, with the implanted device having embolised into the left ventricle. The defect was successfully closed using a pericardial patch, and the embolised device explanted. (Source: Interactive CardioVascular and Thoracic Surgery)

Right to left shunt following radiofrequency catheter ablation of atrial fibrillation in a patient with complex congenital heart disease

Europace — Wed, 20 Jan 2010 16:18:37 +0100

We report a case of an iatrogenic atrial septal defect following left atrial ablation for persistent atrial fibrillation in a patient with a Fontan circulation. Transseptal puncture was performed with two sheaths across a single puncture and left atrial ablation undertaken. Post procedure the patient became cyanosed with right to left shunting. Transcatheter closure immediately improved symptoms and oxygen saturation. (Source: Europace)

Morphologic, Mechanical, Conductive, and Hemodynamic Changes Following Transcatheter Closure of Atrial Septal Defect

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusions. Transcatheter ASD closure is followed by morphologic, conductive, and hemodynamic changes at different time intervals during the first years and results in normalization or near normalization of the heart's structure and function. (Source: Congenital Heart Disease)

Long-Term Follow Up of Secundum Atrial Septal Defect Closure with the Amplatzer Septal Occluder

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusion. These data indicate that for up to 120 months of patient follow-up, the ASO continues to be a safe device. Residual shunts and arrhythmias have low incidence post-ASO placement. Given the mortality in one high-risk patient, further investigation into anti-platelet therapy after device placement is warranted. (Source: Congenital Heart Disease)

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Adults with Down Syndrome: Safety and Long-term Outcome of Cardiac Operation

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

Conclusion. At an experienced center, adult patients with Down syndrome can undergo cardiac surgery with a low risk of mortality and acceptable morbidity. Atrial arrhythmias and pulmonary infections are common postoperatively. (Source: Congenital Heart Disease)

Perventricular Closure of a Large Ventricular Septal Defect in Congenitally Corrected Transposition of the Great Arteries

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

We report the case of a 30 year-old male with congenitally corrected transposition of the great arteries, atrial, and ventricular septal defects (VSD), and pulmonary stenosis. He previously underwent three palliative surgical procedures before undergoing intracardiac repair at age 20 with a left ventricular to pulmonary artery (LV-PA) conduit, VSD closure, and replacement of the systemic atrioventricular valve. A residual VSD was noted postoperatively. He did well for approximately 10 years when he started becoming more breathless with daily activities and was noted to have a resting room air oxygen saturation of 85%. Despite increased diuretic therapy he continued to deteriorate and was ultimately admitted to the hospital in florid right and left heart failure with recurrent atrial fibril...

Cryothermal Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia in a Pediatric Patient after Atrioventricular Canal Repair

Congenital Heart Disease — Wed, 20 Jan 2010 00:00:00 +0100

We describe successful cryothermal modification of the slow atrioventricular nodal pathway in a 12-year-old patient with a previously repaired partial atrioventricular septal defect and inducible atrioventricular nodal reentrant tachycardia. The use of a steerable catheter to locate the displaced His signal combined with the use of cryothermal energy allowed for the safe and effective treatment of this patient's tachycardia. (Source: Congenital Heart Disease)

Oral Manifestations in Ellis-van Creveld Syndrome: Report of a Case and Review of the Literature

Journal of Oral and Maxillofacial Surgery — Tue, 19 Jan 2010 14:19:34 +0100

Ellis-van Creveld syndrome (EVC), initially called chondroectodermal dysplasia, was first described in 1940 by the pediatricians Richard Ellis and Simon van Creveld. It is a rare recessive autosomal disorder characterized by chondrodysplasia, postaxial polydactyly, ectodermal dysplasia, and congenital malformations, most frequently an atrioventricular septal defect, which is observed in 60% of patients. Even though these 4 features classically define the syndrome, a variable spectrum of clinical manifestations is often present. (Source: Journal of Oral and Maxillofacial Surgery)

Unicuspid Aortic Valve, Hand AnomaliesA Heart-Hand Syndrome.

The American Journal of the Medical Sciences — Tue, 19 Jan 2010 00:00:00 +0100

Authors: Nanda S, Longo S, Arastu MI Embryonic heart and limb development are closely related with >100 known inherited disorders affecting both. Common limb defects include duplication, deficiencies, and hypoplasia. Ventricular septal defects and atrial septal defects are the commonest associated cardiac conditions. A positive association exists between heart defects and limb disorders when these disorders are analyzed separately. Closer associations exist between heart defects and upper limb defects compared with lower limb defects. The majority of limb defects occur in the more distal parts of the affected limb. Genes expressed in both the heart and limb development include TGF-beta, BMP4, Msx transcription factor, HAND gene, retinoic acid receptor, and sonic hedgehog gene. Radia...

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Intermediate-Term Effects of Transcatheter Secundum Atrial Septal Defect Closure on Cardiac Remodeling in Children and Adults

Pediatric Cardiology — Mon, 18 Jan 2010 18:44:04 +0100

Abstract The study aimed to investigate the intermediate-term effects of transcatheter atrial septal defect (ASD) closure on cardiac remodeling in children and adult patients. Between December 2003 and February 2009, 117 patients (48 males, 50 adults) underwent transcatheter ASD closure with the Amplatzer septal occluder (ASO). The mean age of the patients was 15 years, and the mean follow-up period was 25.9 ± 12.4 months. New York Heart Association (NYHA) class, electrocardiographic parameters, and transthoracic echocardiographic (TTE) examination were evaluated before the ASD closure, then 1 day, 1 month, 6 months, 12 months, and yearly afterward. Transcatheter ASD closure was successfully performed for 112 (96%) of the 117 patient...

Pregnancy outcome in patients with complex pulmonary atresia: case report and review of the literature

European Journal of Heart Failure — Mon, 18 Jan 2010 18:16:39 +0100

We report here on the outcome of pregnancy in a woman, aged 36, with complex pulmonary atresia in whom palliative operation had been performed at the age of 23. We review the medical literature on pregnancy course as well as maternal and foetal outcome in cases involving this maternal congenital heart disease. (Source: European Journal of Heart Failure)

Palliative atrial switch operation in a 22-year-old patient with transposition of the great arteries.

The Thoracic and Cardiovascular Surgeon — Sat, 16 Jan 2010 23:16:40 +0100

Authors: Yang HS, Park SY, Park HK, Park YH A 2-year-old boy was diagnosed as having transposition of the great arteries (TGA) and ventricular septal defect (VSD) and underwent pulmonary artery banding. The patient showed slow progression of cyanosis and dyspnea on exertion. Oxygen saturation was 70-75 % and cardiac catheterization showed severe pulmonary hypertension. At the age of 22, the patient underwent a palliative atrial switch operation; oxygen saturation increased to around 95 % and the patient experienced relief of symptoms. Atrial fibrillation and right side pleural effusion occurred but resolved and the patient was discharged. PMID: 20072977 [PubMed - in process] (Source: The Thoracic and Cardiovascular Surgeon)

Altered Cardiac Function and Ventricular Septal Defect in Avian Embryos Exposed to Low-Dose Trichloroethylene

Toxicological Sciences — Fri, 15 Jan 2010 07:59:18 +0100

Trichloroethylene (TCE) is the most frequently reported organic groundwater contaminant in the United States. It is controversial whether gestational TCE exposure causes congenital heart defects. The basis for TCE’s proposed cardiac teratogenicity is not well understood. We previously showed that chick embryos exposed to 8 ppb TCE during cardiac morphogenesis have reduced cardiac output and increased mortality. To further investigate TCE’s cardioteratogenic potential, we exposed in ovo chick embryos to TCE and evaluated the heart thereafter. Significant mortality was observed following TCE exposures of 8–400 ppb during a narrow developmental period (Hamburger-Hamilton [HH] stages 15–20, embryo day ED2.3–3.5) that is characterized by myocardial expansion, secon...

Pearls for Ablation in Congenital Heart Disease

Journal of Cardiovascular Electrophysiology — Fri, 15 Jan 2010 00:00:00 +0100

This article focuses on the technical aspects of catheter ablation of these arrhythmias, due to the challenges presented by the underlying anatomy compared with patients having normal hearts. (J Cardiovasc Electrophysiol, Vol. pp. 1-8) (Source: Journal of Cardiovascular Electrophysiology)

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Pancreatic hypoplasia presenting with neonatal diabetes mellitus in association with congenital heart defect and developmental delay

American Journal of Medical Genetics Part A — Fri, 15 Jan 2010 00:00:00 +0100

We report on a series of three patients with pancreatic agenesis and congenital heart defects. All had abdominal scan evidence of pancreatic agenesis. In addition, Patient 1 had a ventricular septal defect, patent ductus arteriosus and pulmonary artery stenosis; Patient 2 had a truncus arteriosus and Patient 3 had tetralogy of Fallot. Two of the three patients have developmental delay. All three patients were isolated cases within the family. Investigations included sequencing of GCK, ABCC8, IPF1, NEUROD1, PTF1A, HNF1B, INS, ISL1, NGN3, HHEX, G6PC2, TCF7L2, SOX4, FOXP3 (Patients 1 and 2), GATA4 and KCNJ11 genes (all three patients), but no mutations were found. Genetic investigation to exclude paternal UPD 6, methylation aberrations and duplications of 6q24 was also negative in all three. ...

Palliative Atrial Switch Operation in a 22-Year-Old Patient with Transposition of the Great Arteries

The Thoracic and Cardiovascular Surgeon — Thu, 14 Jan 2010 16:42:21 +0100

Thorac cardiovasc Surg 2010; 58: 45-47DOI: 10.1055/s-2008-1039232AbstractA 2-year-old boy was diagnosed as having transposition of the great arteries (TGA) and ventricular septal defect (VSD) and underwent pulmonary artery banding. The patient showed slow progression of cyanosis and dyspnea on exertion. Oxygen saturation was 70–75 % and cardiac catheterization showed severe pulmonary hypertension. At the age of 22, the patient underwent a palliative atrial switch operation; oxygen saturation increased to around 95 % and the patient experienced relief of symptoms. Atrial fibrillation and right side pleural effusion occurred but resolved and the patient was discharged.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | ...

Late device thrombosis after atrial septal defect closure

European Heart Journal — Thu, 14 Jan 2010 08:06:40 +0100

(Source: European Heart Journal)

Vegetation With Ventricular Septal Defect Detected by Cardiac Magnetic Resonance Imaging.

Circulation Journal — Thu, 14 Jan 2010 00:00:00 +0100

Authors: Kurita T, Tanabe M, Kitagawa K, Onishi K, Shimpo H, Sakuma H, Ito M PMID: 20075557 [PubMed - as supplied by publisher] (Source: Circulation Journal)

Popliteal pterygium associated with atrial septal defect

European Journal of Orthopaedic Surgery & Traumatology — Mon, 11 Jan 2010 18:20:50 +0100

Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0572-1Authors Hironobu Koseki, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 JapanToshiyuki Tsurumoto, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 JapanHiroyuki Shindo, Nagasaki University Department of Orthopedic Surgery, Graduate School of Biomedical Science 1-7-1, Sakamoto Nagasaki 852-8501 Japan Journal European Journal of Orthopaedic Surgery & TraumatologyOnline ISSN 1432-1068Print ISSN 1633-8065 (Source: European Journal of Orthopaedic Surgery & Traumatology)

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Bilateral lung transplantation with closure of ventricular septal defect in a patient with Eisenmenger syndrome

General Thoracic and Cardiovascular Surgery — Fri, 08 Jan 2010 13:53:25 +0100

We report the first case with Eisenmenger syndrome secondary to an isolated perimembranous ventricular septal defect (VSD) in a patient who underwent bilateral lung transplantation and closure of the VSD in Japan. This male patient was diagnosed as having a VSD associated with severe pulmonary hypertension at the age of 7, and right unilateral pulmonary artery banding was performed at age 9. At 38 years of age, we performed bilateral cadaveric lung transplantation with patch closure of the VSD. Explant pathology revealed grade 3 for the right lung and grade 4 for the left lung by the Heath-Edwards classification. The ventricular contractility had gradually improved, and ventricular arrhythmia requiring amiodarone prior to lung transplantation had disappeared. When cardiac function is...

Congenital Left Ventricle-to-Pulmonary Artery Fistula

Journal of the American College of Cardiology — Fri, 08 Jan 2010 13:50:11 +0100

An 11-month-old girl presented with tachypnea and a grade 3/6 systolic heart murmur on her physical examination when receiving a scheduled vaccination. Chest radiography showed cardiomegaly and increased lung markings. Transthoracic color Doppler echocardiography showed a type-2 atrial septal defect and an abnormal turbulent flow from the lateral wall of the left ventricle (LV), but both coronary arteries appeared normal. Cardiac catheterization was performed that revealed 2 oxygen-saturation step-ups, 1 at the right ventricle (from 62% to 85%) and the other at the pulmonary artery (PA) (from 85% to 87%), with a total Qp/Qs of 3.5. An angiogram of the LV showed 2 fistulas originated from the lateral wall of the LV and then joined together to drain into the posterior-lateral side of the PA ...

The Year in Congenital Heart Disease

Journal of the American College of Cardiology — Fri, 08 Jan 2010 13:50:10 +0100

With the increasing number of excellent papers related to congenital heart disease, it has become more difficult to select those that are perceived to be particularly critical to scientific developments in the field. I have chosen in this review to focus almost entirely on results and to follow surgical- or catheter-based interventions that highlight the complex conditions that surgeons and cardiologists now are able to repair or palliate successfully. Sections chosen are tetralogy of Fallot (TOF), Fontan operation, cardiac surgery in general, transposition of the great arteries (TGA), hypoplastic left heart syndrome (HLHS), aortic valve surgery, aortoplasty, and ventricular septal defect (VSD) management. These particular areas were chosen because of the importance to the general field of...

Cardiac remodeling and effects on exercise capacity after interventional closure of atrial septal defects in different adult age groups

Clinical Research in Cardiology — Fri, 08 Jan 2010 09:08:53 +0100

Conclusion Patients benefit from interventional closure of hemodynamically significant ASD regardless of their age. However, the defect should be repaired as early as possible to prevent hemodynamic complications, such as the development of pulmonary hypertension and cardiac arrhythmias. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-009-0105-2Authors Smita Jategaonkar, Städt. Klinikum Braunschweig Department of Internal Medicine 2 Braunschweig GermanyWerner Scholtz, Ruhr University Bochum Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia Georgstr. 11 32545 Bad Oeynhausen GermanyHenning Schmidt, Ruhr University Bochum Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia Georgstr. 11 32545 Bad Oeynh...

Congenital malformations in infants born after in vitro fertilization in Sweden

Birth Defects Research Part A: Clinical and Molecular Teratology — Fri, 08 Jan 2010 00:00:00 +0100

The risk for congenital malformations is increased in infants born after in vitro fertilization (IVF). Some specific malformations appear to be more affected than others.The presence of congenital malformations in 15,570 infants born after IVF with an embryo transfer between April 1, 2001, and the end of 2006 were compared with all infants born in Sweden during 2001 to 2007 (n = 689,157). Risk estimates were made after adjusting for year of birth, maternal age, parity, smoking, and body mass index. The risks of specific malformations were compared with data from a previous study (1982 to March 31, 2001) of 16,280 infants born after IVF. Different IVF methods were compared to respect to malformation risk.Increased risks of a similar magnitude were found for most cardiovascular malformations...

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Incidence of atrial fibrillation after percutaneous closure of patent foramen ovale and small atrial septal defects in patients presenting with cryptogenic stroke

International Journal of Stroke — Thu, 07 Jan 2010 00:00:00 +0100

The occurrence of atrial fibrillation after percutaneous closure of a patent foramen ovale for cryptogenic stroke has been reported in a variable percentage of patients. However, its precise incidence and mechanism are presently unclear and remain to be elucidated. Prospective follow-up study. Ninety-two patients undergoing a percutaneous patent foramen ovale closure procedure (closure group) for cryptogenic stroke were compared with a similar group of 51 patients, who were medically treated. A systematic arrhythmia follow-up protocol to assess the incidence of AF was performed including a 7-day event-loop recording at day 1, after 6 and 12 months in patients of the closure group and compared with those of the medically treated group. The incidence of AF was similar in both study groups du...

Late Bacterial Endocarditis of an Amplatzer Atrial Septal Defect Occluder Device

The American Journal of Cardiology — Tue, 05 Jan 2010 13:52:39 +0100

In conclusion, the present report is the first description of late infective endocarditis in an adult with an ASO. (Source: The American Journal of Cardiology)

Restrictive ventricular septal defect and critical subaortic stenosis in tetralogy of Fallot

Clinical Research in Cardiology — Tue, 05 Jan 2010 06:46:09 +0100

Conclusion In tetralogy of Fallot, accessory tricuspid valve tissue may obstruct the VSD as well as the left ventricular outflow tract resulting in a life threatening condition in newborns shortly after birth. Content Type Journal ArticleCategory Clinical CorrespondenceDOI 10.1007/s00392-009-0111-4Authors Gunter Kerst, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyRenate Kaulitz, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyLudger Sieverding, University Children’s Hospital Department of Pediatric Cardiology Hoppe-Seyler-Str. 1 72076 Tübingen GermanyChristian Apitz, University Children’s Hospital Department of Pediatric Cardiology Hoppe...

Early timing of surgical intervention in patients with Ebstein's anomaly predicts superior long-term outcome [Original articles]

European Journal of Cardio-Thoracic Surgery — Mon, 04 Jan 2010 16:40:24 +0100

Conclusions: Repair, as opposed to replacement, is feasible in the vast majority of patients presenting with Ebstein's anomaly with a low early mortality rate. Outcome, in terms of survival and freedom from re-operation in the long term is determined by the clinical state at the time of surgery. Therefore, timely operation is warranted before significant cardiomegaly develops and functional status deteriorates. (Source: European Journal of Cardio-Thoracic Surgery)

Fast-track paediatric cardiac surgery: the feasibility and benefits of a protocol for uncomplicated cases [Original articles]

European Journal of Cardio-Thoracic Surgery — Mon, 04 Jan 2010 16:40:24 +0100

Conclusion: A fast-track programme can be implemented safely and effectively if the appropriate support including a step-down ward area is put in place. Greater experience with this type of protocol leads to reductions in the length of hospital stay for children aged over 6 months undergoing uncomplicated open-heart surgery. Fast-track cases should be performed in the morning. (Source: European Journal of Cardio-Thoracic Surgery)

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Closure of a coexisting ostium secundum atrial septal defect and patent foramen ovale using a single Amplatzer patent foramen ovale occluder device

Cardiovascular Revascularization Medicine — Fri, 01 Jan 2010 00:00:00 +0100

We report the case of a 59-year-old man with cryptogenic stroke who was found to have both an ostium secundum atrial septal defect and a patent foramen ovale (PFO) by intracardiac echocardiography. Both defects were successfully occluded using a single 35-mm Amplatzer PFO occluder device inserted through the atrial septal defect. (Source: Cardiovascular Revascularization Medicine)

Aorto-Left Atrial Fistula Post-Percutaneous Device ASD Closure

Heart, Lung & Circulation — Fri, 01 Jan 2010 00:00:00 +0100

We describe a case of perforation with intracardiac fistula formation, with an underlying mechanism likely to be similar to the few cases previously described, occurring during medium term follow up after ASD device closure. Appropriate case selection can reduce the incidence of this complication with caution taken in ASD cases with deficient aortic and superior rims. (Source: Heart, Lung & Circulation)

Role of intraoperative echocardiography in surgical correction of the superior sinus venosus atrial septal defect.

Annals of Cardiac Anaesthesia — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Gadhinglajkar S, Sreedhar R, Jayakumar K, Misra M, Ganesh S, Mathew T Superior type of sinus venosus atrial septal defect (SVASD) is invariably associated with the unroofing of right upper pulmonary vein (RUPV). Warden procedure and pericardial patch repair with rerouting of the RUPV are commonly performed operations for the superior SVASD. Both operations involve the risk of obstruction to the flow of superior vena cava or rerouted pulmonary vein in the postoperative period. The sinus venosus defects are well visualized on the transesophageal echocardiography (TEE) because of the proximity of the TEE probe to these structures. We are reporting two cases operated for the superior SVASD with unroofed RUPV, highlighting the intraoperative echocardiographic features before and af...

Abdominal aortic embolization of a figulla atrial septum occluder device, at the level of the celiac axis, after an atrial septal defect closure: hybrid attempt.

Vascular — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Jahrome AKh, Stella PR, Leijdekkers VJ, Guyomi SH, Moll FL A 41-year-old woman was treated with a Figulla (Occlutec, Helsingborg, Sweden) atrial septum occluder device with no intraprocedural complications. Five months later, dislocation of the device in the abdominal aorta was detected. The occluder device was located at the level of the celiac axis, nearly obstructing the entire aorta. Owing to total incorporation of the device, endoluminal retrieval was not possible. Through a medial rotation approach, the device was safely removed. This is a rare complication after endoluminal closure of an atrial septum defect. The retrieval possibilities are discussed. PMID: 20122364 [PubMed - in process] (Source: Vascular)

[Left ventricular non-compaction in an infant with congenital heart defect.]

Kardiologia Polska — Fri, 01 Jan 2010 00:00:00 +0100

We report a case of a child with NCLV and coexisting hemodynamic significant ventricular septal defect. PMID: 20131191 [PubMed - in process] (Source: Kardiologia Polska)

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Case report Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Intra-aortic balloon counterpulsation is often used in critically ill patients with cardiac disease. Commonly accepted indications for its use include cardiogenic shock and mechanical complications of acute myocardial infarction (e.g. ventricular septal defect). The potential benefits of counterpulsation must be weighed against its possible severe thrombotic and hemorrhagic complications. Here we describe a 72-year old female with interventricular septum rupture complicating the course of acute myocardial infarction, in whom the intra-aortic balloon was used to stabilize the circulation prior to the surgery. Despite anticoagulation she developed a thrombus in the abdominal aorta. The risk – benefit ratio and possible ways to predict the complications are discussed. (Source: Articles ...

CASE REPORTS: Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Congenital Complete Absence of the Left Pericardium: A Rare Cause of Chest Pain or Pseudo-right Heart Overload

Clinical Cardiology — Wed, 30 Dec 2009 00:00:00 +0100

We report the cases of 3 patients who have been seen in our institution with a diagnosis of total congenital absence of the pericardium. All of them complained of precordial pain; one of them experienced disabling symptoms that justified surgical intervention. All of them had previously been suspected to have an atrial septal defect because of the echocardiographic appearance of right ventricular volume overload. Electrocardiogram, chest x-ray, echocardiography, and magnetic resonance imaging of the heart consistently showed remarkably similar features including leftward displacement, increased mobility, and interposition of lung tissue between the heart and other intrathoracic structures.Congenital absence of the left pericardium should be known by clinicians as a possible differential di...

22q11.2 Microdeletion in a Fetus With Double-outlet Right Ventricle, Pulmonary Stenosis and a Ventricular Septal Defect: Prenatal Diagnosis by Array Comparative Genomic Hybridization

Taiwanese Journal of Obstetrics and Gynecology — Mon, 28 Dec 2009 14:44:34 +0100

No abstract (Source: Taiwanese Journal of Obstetrics and Gynecology)

Clinical value of stereoscopic three-dimensional echocardiography in assessment of atrial septal defects: Feasibility and efficiency

Journal of Huazhong University of Science and Technology -- Medical Sciences -- — Mon, 28 Dec 2009 06:42:29 +0100

Summary Stereoscopic three-dimensional echocardiography(S-3DE) is a novel displaying technology based on real-time 3-dimensional echocardiography (RT-3DE). Our study was to evaluate the feasibility and efficiency of S-3DE in the diagnosis of atrial septal defect (ASD) and its use in the guidance for transcatheter ASD occlusion. Twelve patients with secundum ASD underwent RT-3DE examination and 9 of the 12 were subjected to transcatheter closure of ASD. Stereoscopic vision was generated with a high-performance volume renderer with red-green stereoscopic glasses. S-3DE was compared with standard RT-3D display for the assessment of the shape, size, and the surrounding tissues of ASD and for the guidance of ASD occlusion. The appearance rate of coronary sinus and the mean form...

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Prenatal double aortic arch presenting with a right aortic arch and an anomalous artery arising from the ascending aorta

The International Journal of Cardiovascular Imaging — Wed, 23 Dec 2009 22:57:21 +0100

We report here on three fetal cases of double aortic arch and their outcomes. These malformations presented as an isolated right aortic arch or as a typical vascular ring form on the prenatal echocardiography that was obtained between 22 and 24 weeks gestation. In two of the three patients, the major intracardiac anomaly was a ventricular septal defect, and this was associated with the aortic malformation. A more detailed evaluation of the branching pattern of the aorta, and particularly whether the aorta gives off a left-sided limb of the double arch, could suggest the diagnosis of a double aortic arch in utero. Two patients underwent successful surgical correction and they showed good clinical outcomes. Fetal double aortic arch can be prenatally suspected after performing feta...

Cardiopulmonary bypass flow rate: A risk factor for hyperlactatemia after surgical repair of secundum atrial septal defect in children

The Journal of Thoracic and Cardiovascular Surgery — Wed, 23 Dec 2009 16:15:28 +0100

Conclusion: Lower weight-indexed cardiopulmonary bypass flow rate is an independent risk factor for early postoperative hyperlactatemia in children after atrial septal defect repair. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Behavior of Unrepaired Perimembranous Ventricular Septal Defect in Young Adults

The American Journal of Cardiology — Wed, 23 Dec 2009 00:00:00 +0100

In conclusion, mid-term follow-up of adolescents and young adults with a small and unrepaired pmVSD was not uneventful. Some patients required intervention, but in others, spontaneous closure occurred. Electrocardiographic and structural changes were noticed, for which the clinical significance needs to be determined. (Source: The American Journal of Cardiology)

Role of 64-MDCT in Evaluation of Pulmonary Atresia With Ventricular Septal Defect

American Journal of Roentgenology — Tue, 22 Dec 2009 19:02:37 +0100

CONCLUSION. The management of this complex condition has been largely determined by the morphology of pulmonary arteries and the extracardiac sources of pulmonary blood supply. Although echocardiography and catheter angiography are the traditional imaging techniques used to diagnose PA-VSD, 64-MDCT has become a valuable noninvasive imaging technique in comprehensive evaluation of this condition. (Source: American Journal of Roentgenology)

Nigeria: Saraki's Wife Gives Hole in Heart Child N.4 Million

AllAfrica News: Health and Medicine — Mon, 21 Dec 2009 09:06:03 +0100

Alaafia Kwara, a non-governmental organisation (NGO) of the wife of the Kwara State governor, Mrs. Oluwatoyin Saraki, has donated N400,000 out of N2.5 million for the treatment of a 19-month-old Agachukwu Ovu, who was diagnosed with a hole in the heart. (Source: AllAfrica News: Health and Medicine)

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Surgical Revision After Percutaneous Mitral Repair With the MitraClip Device [ORIGINAL ARTICLES: ADULT CARDIAC]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

Conclusions Standard surgical options were preserved in patients who had surgery after percutaneous repair with the MitraClip device. Successful repair was feasible in the majority of patients after the MitraClip procedure, with repair performed as late as 18 months after clip implantation. (Source: The Annals of Thoracic Surgery)

The Performance of Hancock Porcine-Valved Dacron Conduit for Right Ventricular Outflow Tract Reconstruction [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

Conclusions The Hancock valved conduit is a safe and reliable alternative to homografts. It appears to be appropriate in patients with limited pulmonary vascular bed and high pulmonary artery pressures. Caution is required in neonates because of the rigidity of the Dacron housing. Initial results with secondary percutaneous procedures are encouraging. (Source: The Annals of Thoracic Surgery)

Late Reoperation After Reimplantation of an Anomalous Single Coronary Artery From the Pulmonary Artery [CASE REPORTS]

The Annals of Thoracic Surgery — Fri, 18 Dec 2009 23:25:12 +0100

A 14-year-old girl with an anomalous origin of a single coronary artery from the pulmonary artery, moderate mitral insufficiency, and an outlet ventricular septal defect, underwent direct reimplantation of the single coronary artery (SCA) to the aorta and closure of the ventricular septal defect at 6 months of age. She had stenosis of the proximal single coronary artery develop 14 years after the initial operation. A patch augmentation of her proximal SCA was successfully performed, and a postoperative coronary angiographic scan taken 3 months after her surgery showed a widely patent SCA without any residual narrowing. (Source: The Annals of Thoracic Surgery)

Chronic Intermittent Materno-Fetal Hyperoxygenation in Late Gestation May Improve on Hypoplastic Cardiovascular Structures Associated with Cardiac Malformations in Human Fetuses

Pediatric Cardiology — Fri, 18 Dec 2009 18:20:24 +0100

Abstract Hypoplasia of cardiovascular structures is a common finding in fetuses with cardiac malformations. Materno-fetal hyperoxygenation (HO) during late gestation promotes venous return to the fetal heart. This analysis in human fetuses sought to define whether this “loading” effect might improve hypoplastic cardiovascular dimensions. Fifteen late-gestation fetuses presented with varying degrees of hypoplastic cardiovascular structures. In these cases, chronic intermittent materno-fetal HO was administered during periods ranging from 8 to 33 days. Cardiac measurements were taken before and at the end of treatment and translated into Z-scores as well as plotted on normal growth charts. During the treatment period, chronic intermittent materno-fetal HO was associ...

New Gene Linked To Congenital Heart Defects

Health News from Medical News Today — Fri, 18 Dec 2009 08:00:00 +0100

Researchers from the UC San Diego, School of Medicine and colleagues have identified a new gene, ETS-1, that is linked to human congenital heart defects. The landmark study, recently published online in the journal of Human Molecular Genetics, provides important insights into some of the most prevalent forms of congenital heart defects in humans, including ventricular septal defects and potentially hypoplastic left heart syndrome, a uniformly fatal heart abnormality... (Source: Health News from Medical News Today)

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Right or left anterolateral minithoracotomy for repair of congenital ventricular septal defects in adult patients [Institutional report - Congenital]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

For most patients who present with ventricular septal defects (VSDs) in adulthood, the major concern is not the mortality or morbidity associated with repair surgery, but rather cosmetic problems arising from surgical scarring as a result of median sternotomy. From March 2005 to August 2008, nine patients (M:F=1:8) underwent repair of congenital VSD using right (n=7) or left (n=2) anterolateral minithoracotomy. We compared the perioperative data of these patients with that of the patients (n=8) who underwent VSD repair using median sternotomy during the same period. VSDs were of the perimembranous (n=6), subarterial (n=1), muscular inlet (n=1), and muscular outlet (n=1) type in minithoracotomy group. There was no in-hospital mortality in both groups. Mean cardiopulmonary bypass (CPB) time ...

eComment: Re: Right or left anterolateral minithoracotomy for repair of congenital ventricular septal defects in adult patients [eComment]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

(Source: Interactive CardioVascular and Thoracic Surgery)

eComment: A limited antero-lateral minithoracotomy for congenital ventricular septal defects repair in adult patients [eComment]

Interactive CardioVascular and Thoracic Surgery — Thu, 17 Dec 2009 16:35:38 +0100

(Source: Interactive CardioVascular and Thoracic Surgery)

Atrial septal defect (ASD): Readily treatable heart defect

MayoClinic.com Full Feed — Thu, 17 Dec 2009 06:00:00 +0100

Atrial septal defect (ASD) — Comprehensive overview covers symptoms, causes, treatment of this common heart defect. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

Echocardiographic Detection of Atrial Septal Defects: The Forgotten View

Echocardiography — Thu, 17 Dec 2009 00:00:00 +0100

We describe two cases in which the right parasternal view was helpful in assessment of the interatrial septum and the detection of atrial septal defects (ASD), including one case in which this view confirmed the presence of a defect not seen in any other echocardiographic view. Use of the right parasternal view should be considered for assessment of the interatrial septum, particularly when there is a high index of suspicion for an atrial septal defect but no defect is seen on conventional views. It should also be used to exclude the possibility of multiple defects even when an ASD is visualized using conventional imaging planes. (ECHOCARDIOGRAPHY, Volume **, ************) (Source: Echocardiography)

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Electroanatomic Relationships in Patients With Primum Atrioventricular Septal Defect

Journal of the American College of Cardiology: Cardiovascular Imaging — Mon, 14 Dec 2009 22:01:29 +0100

Conclusions Abnormality in the position of the papillary muscles changes continuously with the abnormality of the QRS axis. Understanding the electroanatomic relationships provides important insight into developmental relationships between the conduction system and the trabecular structures in primum AVSD patients. These results may provide insights in understanding the continuity of primum AVSD abnormality, in estimating the best surgical approach, and predicting the prognosis of primum AVSD patients. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)

Atrioventricular septal defect with tetralogy of Fallot in patient with Down's syndrome

Revista Brasileira de Cirurgia Cardiovascular — Sat, 12 Dec 2009 16:02:07 +0100

We present a case of a 44-year-old man with prosthetic aortic endocarditis complicated by a perivalvular abscess. He evolved with improvement of the infectious process only under clinical treatment. The patient presented a prior history of rheumatic fever and had previously been undergone three valve replacements due to prosthesis dysfunction and previous endocarditis. In this case report we discuss the main features of perivalvular abscess complicating infective endocarditis (Source: Revista Brasileira de Cirurgia Cardiovascular)

Endoscopic treatment of tracheobronchial tree fistulas using atrial septal defect occluders: preliminary results

Jornal Brasileiro de Pneumologia — Sat, 12 Dec 2009 15:06:49 +0100

We report the cases of three patients submitted to endoscopic closure of fistulas, two of which were larger than 10 mm in diameter, by means of the insertion of atrial septal defect occluders. The procedure was minimally invasive, and the initial results were positive. The results indicate that this is a promising technique for the resolution of tracheobronchial tree fistulas. (Source: Jornal Brasileiro de Pneumologia)

Distal femoral duplication and fibular agenesis associated with congenital cardiac defect

Indian Journal of Pediatrics — Sat, 12 Dec 2009 14:30:38 +0100

We report a newborn, who had the congenital anomalies including protuberance on the right lower leg, bilateral equinovarus deformity of the feet, genu valgum with knee flexion deformity, syndactyly between the first and the second digit on the right, in addition with the absence of the fifth digit. Echocardiography revealed a secundum type atrial septal defect. The combination of these congenital defects associated with developmental anomalies of lower extremities. We discuss the clinical, radiological findings and pathogenesis of this lower extremity malformation. Content Type Journal ArticleCategory Clinical BriefDOI 10.1007/s12098-009-0228-5Authors Murat Cakir, Karadeniz Technical University Faculty of Medicine, Department of Pediatrics Trabzon TurkeyLies H. Hoefsloot, Radboud ...

Emergency balloon dilation or stenting of critical coarctation of aorta in newborns and infants: An effective interim palliation

Annals of Pediatric Cardiology — Sat, 12 Dec 2009 13:50:44 +0100

Conclusion</b> : Balloon dilation &#177; stenting is an effective interim palliation for infants and newborns with critical coarctation and LV dysfunction. Restenosis is inevitable and requires to be addressed. (Source: Annals of Pediatric Cardiology)

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Radiofrequency ablation in an infant with recurrent supraventricular tachycardia and cyanosis

Annals of Pediatric Cardiology — Sat, 12 Dec 2009 13:50:44 +0100

We report an unusual presentation of supraventricular tachycardia, in an infant, with cyanosis. The child had atrial septal defect with hypoplastic right ventricle. Radiofrequency ablation was performed in view of drug resistant SVT (Source: Annals of Pediatric Cardiology)

Molecular genetics of congenital atrial septal defects

Clinical Research in Cardiology — Fri, 11 Dec 2009 06:52:17 +0100

Abstract Congenital heart defects (CHD) are the most common developmental errors in humans, affecting 8 out of 1,000 newborns. Clinical diagnosis and treatment of CHD has dramatically improved in the last decades. Hence, the majority of CHD patients are now reaching reproductive age. While the risk of familial recurrence has been evaluated in various population studies, little is known about the genetic pathogenesis of CHD. In recent years significant progress has been made in uncovering genetic processes during cardiac development. Data from human genetic studies in CHD patients indicate that the genetic aetiology was presumably underestimated in the past. Inherited mutations in genes encoding cardiac transcription factors and sarcomeric proteins were found as an underlyi...

Nigeria: Hole-in-the Heart Boy Needs N2 Million to Live

AllAfrica News: Health and Medicine — Mon, 07 Dec 2009 10:33:40 +0100

He was just a month old when his parents started noticing some symptoms of a health problem in him but it was not until eight months later that it was discovered that the little Aghachukwu Ovu is suffering from tetralogy of fallot, a disease of a hole in the heart. (Source: AllAfrica News: Health and Medicine)

Usefulness of Early Diastolic Mitral Annular Velocity to Predict Plasma Levels of Brain Natriuretic Peptide and Transient Heart Failure Development After Device Closure of Atrial Septal Defect

The American Journal of Cardiology — Sun, 06 Dec 2009 13:50:16 +0100

This study tested the hypothesis that the underlying diastolic dysfunction, assessed on tissue Doppler images (TDI) before device closure, can predict BNP level after ASD closure. The study subjects were 39 consecutive patients (age 27.5 ± 16.3 years, range 5 to 63) who underwent device closure for ASD. Echocardiographic evaluation using TDI and 2-dimensional and pulse wave Doppler were performed, together with plasma BNP measurement 1 day before and 2 days after ASD closure. Before ASD closure, an age-dependent decrease was noted in left ventricular relaxation, assessed by early diastolic mitral annular velocity. ASD closure resulted in a decrease in early diastolic mitral annular velocity (from 14.7 to 12.3 cm/s, p (Source: The American Journal of Cardiology)

Left atrial myxoma with an atrial septal defect.

Cardiology Journal — Thu, 03 Dec 2009 17:14:03 +0100

Authors: Jegier B, Jaszewski R, Lelonek M In a 62-year old woman with arterial hypertension, a left atrial myxoma and a concomitant atrial septal defect, diagnosed intraoperatively, were recognized. The atrial septal defect was not observed pre-operatively by transthoracic and transoesophageal echocardiography with color Doppler. The myxoma was pedunculated and situated on the inferior part of the interatrial septum and moved to the left ventricle in the diastolic phase. The histopathologic finding was consistent with the diagnosis of myxoma. PMID: 19950097 [PubMed - in process] (Source: Cardiology Journal)

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Idiopathic twin aneurysm of right pulmonary artery diagnosed in a case 17 years after a successful surgical repair of ventricular septal defect.

Anadolu Kardiyol Der... — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Ozbek C, Yetkin U, Yürekli I, Gürbüz A PMID: 19965331 [PubMed - in process] (Source: Anadolu Kardiyol Der...)

The oxidative state of children with cyanotic and acyanotic congenital heart disease.

Anadolu Kardiyol Der... — Tue, 01 Dec 2009 00:00:00 +0100

CONCLUSION: The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar. PMID: 19965321 [PubMed - in process] (Source: Anadolu Kardiyol Der...)

A Family Health Question: What About Dad?

Journal of Men's Health — Tue, 01 Dec 2009 00:00:00 +0100

Men's health may be considered a vital but often overlooked aspect of family health. The health status of adult males has often been dismissed as irrelevant to the well-being of the family. However, the family is built on highly interactive relationships such that the health challenges facing fathers frequently have widespread and demonstrable negative effects on the health of the family as a whole. Following widowhood or disability of a husband, a family may face the loss of a long term companion and considerable bereavement, as well as a difficult burden of care for the disabled person. Surviving spouses face an increased risk of dying over the course of the next year. In disability, a family is likely to face increased health care expense in the face of diminished earnings. Poverty is s...

Spectrum of congenital heart diseases in Kashmir, India.

Indian Pediatrics — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Ashraf M, Chowdhary J, Khajuria K, Reyaz AM A retrospective analysis of case-records data of 53,653 patients (0-18 years) over a two and half year period was conducted to ascertain the spectrum of congenital heart diseases. Two hundred and twenty one patients were found having congenital heart diseases; a prevalence of 4.1/1000. Ventricular septal defect (VSD) was the most frequent lesion seen in 69 (31.2%), followed by patent ductus arteriosus (PDA) in 36 (16.3%) children. Tetralogy of Fallot (TOF) was the most frequent cyanotic heart disease seen in 17 (7.8%) patients. PMID: 20061593 [PubMed - in process] (Source: Indian Pediatrics)

Med Sci Monit 2009; 15(12):CR612-617 "Transcatheter closure as an alternative and equivalent method to the surgical treatment of atrial septal defect in adults: Comparison of early and late results"

Medical Science Monitor — Mon, 30 Nov 2009 15:38:22 +0100

Conclusions: As surgical and device closure appear similarly effective in adults with ASD, avoidance of thoracotomy and cardiopulmonary bypass, in conjunction with a shorter hospital stay, argues in favour of device closure in selected patients. (Source: Medical Science Monitor)

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Tetralogy of Fallot: Yesterday and Today

World Journal of Surgery — Sun, 29 Nov 2009 09:38:24 +0100

This article presents a review of TOF, including the history of surgical treatment, present-day approaches, and long-term outcomes. Content Type Journal ArticleDOI 10.1007/s00268-009-0296-8Authors Joanne P. Starr, University of Medicine and Dentistry of New Jersey Department of Surgery Newark NJ 07103 USA Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

Coarctation of the Aorta: Midterm Outcomes of Resection With Extended End-to-End Anastomosis.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:18 +0100

CONCLUSIONS: Repair of coarctation of the aorta with resection with extended end-to-end anastomosis has a low early mortality, effectively addresses transverse arch hypoplasia, and at midterm follow-up has a low rate of reintervention for recurrent coarctation. PMID: 19932265 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Arterial switch for transposition of the great vessels and taussig-bing anomaly after six months of age.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:11 +0100

CONCLUSIONS: Arterial switch operation shows satisfactory operative outcome of transposition of the great arteries plus ventricular septal defect or Taussig-Bing anomaly in children older than the age of 6 months with moderate-to-severe pulmonary hypertension. PMID: 19932267 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Early and intermediate outcome after anatomic repair of congenitally corrected transposition of the great arteries.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:08:08 +0100

CONCLUSIONS: Senning/arterial switch operations can be performed with excellent intermediate-term outcomes in patients with lesions previously thought to confer higher risk. Candidates for Senning/Rastelli procedures may be at increased risk for postoperative morbidity and mortality. More data are necessary to determine factors influencing outcome after anatomic repair. PMID: 19932268 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Metal allergy to amplatzer occluder device presented as severe bronchospasm.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:07:16 +0100

We report a case of severe bronchospasm secondary to a metal allergy after an atrial septal defect device closure requiring device removal. PMID: 19932286 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

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Tricuspid and aortic valve and ventricular septal defect endocarditis: an unusual presentation of acute q Fever.

The Annals of Thoracic Surgery — Sat, 28 Nov 2009 00:07:04 +0100

We report a case of Q fever endocarditis involving the tricuspid and aortic valves and a congenital ventricular septal defect. Surgical treatment and distinct aspects of this unusual case are herein described. PMID: 19932290 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Prenatal diagnosis of left atrial isomerism

Heart — Fri, 27 Nov 2009 18:01:44 +0100

Conclusion: Left atrial isomerism presents a varied spectrum of cardiac malformations when it is detected prenatally. Complete heart block, complex cardiac abnormalities and fetal hydrops are poor prognostic features. Those with only minor cardiac malformations are at risk postnatally for biliary atresia and for bowel obstruction due to malrotation. (Source: Heart)

High serum levels of procollagen type III N-terminal amino peptide in patients with congenital heart disease

Heart — Fri, 27 Nov 2009 18:01:44 +0100

Conclusion: The increased serum PIIIP levels in proportion to the severity of ventricular load or cyanosis suggest enhanced myocardial synthesis of collagen type III in patients with CHD. Suppression of the PIIIP level by ACEI suggests the involvement of the renin–angiotensin–aldosterone system in myocardial fibrosis. These data provide the basis for the development of new diagnostic and therapeutic strategies in patients with CHD. (Source: Heart)

Giant right ventricular fibroma co-existing atrial septal defect in a 15 year old girl

Cardiology in the Young — Fri, 27 Nov 2009 13:52:36 +0100

In this report, we describe a giant ventricular fibroma co-existing with an atrial septal defect in a girl aged 15 years. (Source: Cardiology in the Young)

Atrial Standstill Causing Congestive Heart Failure in a Child with Ostium Secundum Atrial Septal Defect

Pediatric Cardiology — Wed, 25 Nov 2009 16:49:03 +0100

Abstract Atrial septal defects of the ostium secundum variety are typically asymptomatic in infancy and early childhood. Congestive heart failure (CHF) may occur in the presence of significant mitral valve disease, pulmonary artery hypertension, or other diseases that lead to elevated filling pressures of the ventricles. Atrial standstill, a rare disease, was the probable cause of CHF in the 3-year-old child discussed in this report. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00246-009-9578-zAuthors Ishwar Chandra Malav, All India Institute of Medical Sciences Department of Cardiology, Cardiothoracic Centre Ansari Nagar New Delhi 110029 IndiaRajnish Juneja, All India Institute of Medical Sciences Department of Cardiology, Cardiothoracic Centre Ansari Na...

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A Single-Center Experience with Intracardiac Thrombosis in Children with Dilated Cardiomyopathy

Pediatric Cardiology — Tue, 24 Nov 2009 07:08:39 +0100

This study investigated the incidence, risk factors, and outcome of intracardiac thrombosis in children with dilated cardiomyopathy. A retrospective review of the clinical records was performed in 83 children with dilated cardiomyopathy diagnosed from January 1995 to December 2008. Intracardiac thrombi were detected in 5 patients (6.0%). The intracardiac thrombi were found mainly in the left ventricle (n = 3). One patient had a thrombus in the left atrium at the time of diagnosis, and a right ventricular thrombus was found in 1 patient with unrepaired ventricular septal defect complicated by pulmonary hypertension. Intracardiac thrombosis developed during rapid deterioration of ventricular function, and all patients had a poor ejection fraction of the left ventricle. All pa...

Retrieval of an embolized amplatzer septal occluder

Catheterization and Cardiovascular Interventions — Tue, 24 Nov 2009 00:00:00 +0100

Percutaneous closure of secundum atrial septal defect (ASD) by various devices has been proven to be an effective and safe treatment modality for patients with congenital heart diseases. However, we have to be aware of the potential early and late complications like device embolization and formulate plan for rescue procedures. We have reported a case of successful closure of a large secundum ASD in a 23-year-old woman by a 40 mm Amplatzer septal occluder (ASO), which embolized into the right ventricle 4 hr after the procedure. This had caused palpitation and nonsustained ventricular tachycardia. Patient safety was our most important concern and after discussion with the cardiac surgeons and the patient, we would like to make a percutaneous stepwise attempt for retrieval. We first applied a...

Coarctation of the Aorta: Midterm Outcomes of Resection With Extended End-to-End Anastomosis [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Mon, 23 Nov 2009 19:29:54 +0100

Conclusions Repair of coarctation of the aorta with resection with extended end-to-end anastomosis has a low early mortality, effectively addresses transverse arch hypoplasia, and at midterm follow-up has a low rate of reintervention for recurrent coarctation. (Source: The Annals of Thoracic Surgery)

Arterial Switch for Transposition of the Great Vessels and Taussig-Bing Anomaly After Six Months of Age [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Mon, 23 Nov 2009 19:29:54 +0100

Conclusions Arterial switch operation shows satisfactory operative outcome of transposition of the great arteries plus ventricular septal defect or Taussig-Bing anomaly in children older than the age of 6 months with moderate-to-severe pulmonary hypertension. (Source: The Annals of Thoracic Surgery)

Early and Intermediate Outcome After Anatomic Repair of Congenitally Corrected Transposition of the Great Arteries [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Mon, 23 Nov 2009 19:29:54 +0100

Conclusions Senning/arterial switch operations can be performed with excellent intermediate-term outcomes in patients with lesions previously thought to confer higher risk. Candidates for Senning/Rastelli procedures may be at increased risk for postoperative morbidity and mortality. More data are necessary to determine factors influencing outcome after anatomic repair. (Source: The Annals of Thoracic Surgery)

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Metal Allergy to Amplatzer Occluder Device Presented as Severe Bronchospasm [CASE REPORTS]

The Annals of Thoracic Surgery — Mon, 23 Nov 2009 19:29:54 +0100

We report a case of severe bronchospasm secondary to a metal allergy after an atrial septal defect device closure requiring device removal. (Source: The Annals of Thoracic Surgery)

Tricuspid and Aortic Valve and Ventricular Septal Defect Endocarditis: An Unusual Presentation of Acute Q Fever [CASE REPORTS]

The Annals of Thoracic Surgery — Mon, 23 Nov 2009 19:29:54 +0100

Atypical atrial flutter in a patient with atrial septal defect without previous surgery: the role of septal defect as a part of the arrhythmia substrate

Europace — Mon, 23 Nov 2009 15:11:54 +0100

This case report describes an atypical right atrial septal flutter in a patient with a non-corrected atrial septal defect. The unique feature of this case report is that reentrant tachycardia with a cycle around the atrial septal defect was non-scar related. The slow conduction around this atrial septal defect was probably formed by right atrial dilatation and intra-cardiac haemodynamic alterations. (Source: Europace)

Amplatzer Septal Occluder Closure of Atrial Septal Defect: Evaluation of Transthoracic Echocardiography, Cardiac CT, and Transesophageal Echocardiography

American Journal of Roentgenology — Fri, 20 Nov 2009 19:03:24 +0100

CONCLUSION. The long axis of a large ASD can be underestimated at TTE. Cardiac CT seems comparable with TEE in the assessment of ASD and is helpful in noninvasive evaluation for Amplatzer septal occluder implantation, especially for large ASD. (Source: American Journal of Roentgenology)

Morphologic spectrum of truncal valvar origin relative to the ventricular septum: Correlation with the size of ventricular septal defect

The Journal of Thoracic and Cardiovascular Surgery — Fri, 20 Nov 2009 16:22:50 +0100

Conclusion: Origin of the truncal valve demonstrated a morphologic spectrum and correlated with the size of ventricular septal defect that was the main or even sole exit from the left ventricle in hearts with right ventricular origin. Truncal origin, therefore, requires recognition to optimize surgery. (Source: The Journal of Thoracic and Cardiovascular Surgery)

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Case 6/2009: 13 years old youngsters with major atrial and ventricular septal defects

Arquivos Brasileiros de Cardiologia — Fri, 20 Nov 2009 13:54:09 +0100

A terapia de ressincronização cardíaca (TRC) tem sido uma opção efetiva nos pacientes com insuficiência cardíaca avançada. No entanto 20% a 30% dos pacientes não apresentam benefícios nessa terapêutica. Critérios clínicos, eletrocardiográficos e ecocardiográficos têm sido estudados na tentativa de selecionar os pacientes que serão beneficiados com a ressincronização cardíaca, mas o ecocardiograma tem papel importante tanto na seleção quanto na avaliação e otimização dessa terapêutica. O objetivo desta revisão é descrever os principais parâmetros ecocardiográficos utilizados na avaliação da terapia de ressincronização cardíaca. (Source: Arquivos Brasileiros de Cardiologia)

[Perfusion strategies of extracorporeal circulation for robotically assisted cardiac surgery.]

Journal of Southern Medical University — Fri, 20 Nov 2009 00:00:00 +0100

CONCLUSION: The establishment of ECC system through peripheral vessels, certain learning curve of perfusion technique and close communication between the surgical team are the key points of ECC for totally robotically assisted cardiac surgery, and VAVD and continuous blood gas monitoring are essential during ECC. PMID: 19923091 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)

Higher Risk of Adverse Pregnancy Outcomes When Septal Defects Are Unrepaired

Medscape Today Headlines — Wed, 18 Nov 2009 16:54:00 +0100

The risk of adverse neonatal events is higher when mothers have unrepaired atrial septal defects, while pregnant women with repaired septal defects have neonatal event rates that are generally similar to controls, researchers say based on a new study. Reuters Health Information (Source: Medscape Today Headlines)

Perioperative management of a neonate with Cantrell syndrome

Journal of Anesthesia — Tue, 17 Nov 2009 23:58:50 +0100

Abstract Cantrell syndrome is a congenital malformation with a pentalogy characterized by defects involving the abdominal wall, lower sternum, anterior diaphragm, and diaphragmatic pericardium, as well as congenital cardiac anomalies. We recently managed anesthesia in a patient with this syndrome and herein report our experience. The patient was a 14-day-old male neonate, who had been diagnosed with Cantrell syndrome, including ventricular septal defect, left ventricular diverticulum, abdominal wall defect, omphalocele, and sternal hypoplasia. Surgical interventions to close the ventricular septal defect, resect the left ventricular diverticulum, and close the omphalocele were scheduled. After cardiac surgery, the hernial contents were returned to their original compartmen...

Ventricular septal defect: Readily treatable hole in the heart

MayoClinic.com Full Feed — Tue, 17 Nov 2009 06:00:00 +0100

Ventricular septal defect — Comprehensive overview covers symptoms, treatment of this common heart defect. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

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GATA4 Mutations in Chinese Patients with Congenital Cardiac Septal Defects

Pediatric Cardiology — Sat, 14 Nov 2009 06:58:57 +0100

Abstract The object of the study was to elucidate the mutations of the GATA4 gene in Han ancestry patients with congenital cardiac septal defects. Fifty Han ancestry patients with sporadic and familial cardiac septal defects and 200 normal subjects of the same ethnical background were studied. A total of six exons and the intron–exon boundaries of GATA4 were amplified by polymerase chain reaction (PCR). The PCR products were purified and directly sequenced with an ABI PRISM 3730 Automatic DNA sequencer. Two novel heterozygous mutations were discovered in the GATA4 gene in five children with cardiac septal defects (10%, 5/50), His28Tyr in exon 2 and His436Tyr in exon 7, respectively, which were neither found in the control population nor reported in the SNP database at the ...

Late Pulmonary Valve Replacement in Congenital Heart Disease Patients Without Original Congenital Pulmonary Valve Pathology

Pediatric Cardiology — Sat, 14 Nov 2009 06:58:50 +0100

This report describes five cases of patients with a history of congenital heart surgery but no congenital pulmonary valve pathology who required pulmonary valve replacement due to the consequences of prolonged pulmonary regurgitation. Although pulmonary regurgitation may be well tolerated for many years, it is further evidence for the importance of close follow-up assessment and monitoring of young adults with congenital heart disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00246-009-9574-3Authors Brian E. Kogon, Emory University School of Medicine, Children’s Healthcare of Atlanta Division of Cardiothoracic Surgery Atlanta GA USAManisha Patel, Children’s Healthcare of Atlanta Sibley Cardiology Atlanta GA USAMaria Pernetz, Emory University School of ...

Left Ventricular Mechanical Synchrony and Global Systolic Function in Pediatric Patients Late after Ventricular Septal Defect Patch Closure: A Three-dimensional Echocardiographic Study

Congenital Heart Disease — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions. Pediatric patients 5[ndash]10 years after VSD patch closure have a normal LV function. The presence of the RBBB causes some mechanical dyssynchrony and tendency toward LV dilatation in this group of patients. Therefore, long-term follow-up of these patients is warranted. (Source: Congenital Heart Disease)

Population-based Assessment of Familial Inheritance and Neurologic Comorbidities among Patients with an Isolated Atrial Septal Defect

Congenital Heart Disease — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions. There is a strong familial inheritance pattern for isolated interatrial shunt, with significantly higher risk of interatrial shunt among affected patients' siblings, first-, and second-degree relatives. Relatives of affected individuals also had a higher risk of TIA, a trend toward an increased risk for stroke, but no increased risk of migraine headache. (Source: Congenital Heart Disease)

Transcatheter closure of postsurgical residual ventricular septal defects: Early and mid-term results

Catheterization and Cardiovascular Interventions — Thu, 12 Nov 2009 00:00:00 +0100

Conclusions: Transcatheter closure of postsurgical residual VSD is safe and efficacious management option and obviates the need for further surgery and by-pass. © 2009 Wiley-Liss, Inc. (Source: Catheterization and Cardiovascular Interventions)

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Large destructive facial hemangioma in PHACE syndrome

Journal of Indian Association of Pediatric Surgeons — Tue, 10 Nov 2009 15:59:27 +0100

We report an infant who presented with large facial hemangioma associated with Dandy-Walker cyst and atrial septal defect. This case is peculiar in that the large facial hemangioma in posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of aorta and other cardiac defects (PHACE) syndrome resulted in massive tissue destruction. (Source: Journal of Indian Association of Pediatric Surgeons)

Noninvasive Assessment of Pulmonary Artery Flow and Resistance by Cardiac Magnetic Resonance in Congenital Heart Diseases With Unrestricted Left-to-Right Shunt

Journal of the American College of Cardiology: Cardiovascular Imaging — Mon, 09 Nov 2009 22:01:22 +0100

Conclusions Measurement of Qp or left-to-right shunt noninvasively by CMR has potential to predict the PVR in patients with an unrestricted left-to-right shunt and could potentially determine operability without having to undertake invasive testing. (Source: Journal of the American College of Cardiology: Cardiovascular Imaging)

ARTICLE: Antibacterial Medication Use During Pregnancy and Risk of Birth Defects: National Birth Defects Prevention Study

Archives of Pediatrics — Mon, 02 Nov 2009 21:01:14 +0100

Conclusions Reassuringly, penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. Sulfonamides and nitrofurantoins were associated with several birth defects, indicating a need for additional scrutiny. (Source: Archives of Pediatrics)

Antibacterial Medication Use During Pregnancy and Risk of Birth Defects: National Birth Defects Prevention Study [Article]

Archives of Pediatrics — Mon, 02 Nov 2009 21:01:14 +0100

CT appearance of persistent left superior vena cava, anomalous right superior pulmonary venous return into the right-sided superior vena cava and a sinus venosus-type atrial septal defect.

The British Journal of Radiology — Sun, 01 Nov 2009 00:00:00 +0100

We present findings of persistent left superior vena cava, anomalous right superior pulmonary venous return into the right-sided superior vena cava and a sinus venosus-type atrial septal defect detected incidentally by CT pulmonary angiography. To our knowledge, there has been no previous case report with all of the above findings detected by CT. In addition to the radiological findings and their clinical significance, the anatomy and embryological explanation of each anomaly is discussed. PMID: 19890118 [PubMed - in process] (Source: The British Journal of Radiology)

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Should we close hypoxaemic patent foramen ovale and interatrial shunts on a systematic basis?

Archives of Cardiovascular Diseases — Sun, 01 Nov 2009 00:00:00 +0100

CONCLUSION: Hypoxaemic shunts are treated effectively by transcatheter closure, resulting in functional improvement in patients without respiratory insufficiency. When associated with chronic respiratory insufficiency, hypoxaemia often persists after shunt closure. In such cases, the right-to-left atrial shunt does not seem to be the main cause of hypoxaemia and the indication for closure is questionable. PMID: 19944391 [PubMed - in process] (Source: Archives of Cardiovascular Diseases)

Percutaneous closure of a secundum atrial septal defect after surgical pericardectomy.

Cardiovascular Journal of Africa — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Yalonetsky S, Lorber A A case of successful closure of a percutaneous atrial septal defect following surgical pericardectomy is described. Clinical and haemodynamic aspects of atrial septal defects associated with constrictive pericarditis are also discussed. PMID: 20024476 [PubMed - in process] (Source: Cardiovascular Journal of Africa)

Repair of atrial septal defects on the perfused beating heart.

Texas Heart Institute Journal — Sat, 31 Oct 2009 12:32:03 +0100

We present our experience in repairing all varieties of atrial septal defects with the aid of continuous antegrade perfusion of an empty beating heart with normothermic blood.From September 1999 through December 2008, 266 patients (140 females and 126 males; ages 3-53 yr) underwent atrial septal defect closure by this method. Of these patients, 236 had ostium secundum, 21 had sinus venosus, and 9 had ostium primum defects. Three patients also had rheumatic mitral incompetence requiring mitral valve implantation, and 2 also had mitral stenosis requiring valvuloplasty. Preoperative diagnoses were established by 2-dimensional echocardiography and color-flow Doppler study. The size of atrial septal defects ranged from 2 cm through 4.5 cm. Direct repair was performed in 52 patients, and the res...

[Percutaneous closure of ventricular septal defects in adult patients: our initial experience.]

Turk Kardiyoloji Dernegi arsivi — Sat, 31 Oct 2009 10:30:03 +0100

CONCLUSION: Percutaneous closure of VSDs has become a good alternative to surgical repair in recent years, with high success rates and low morbidity. The results of percutaneous closure of VSDs are also successful in adult patients. PMID: 19875903 [PubMed - as supplied by publisher] (Source: Turk Kardiyoloji Dernegi arsivi)

Preclinical evaluation of a new self-expanding device for closure of muscular ventricular septal defects in a pig model

Catheterization and Cardiovascular Interventions — Sat, 31 Oct 2009 00:00:00 +0100

Aim of our study was the preclinical evaluation of a new self expanding device for interventional closure of muscular ventricular septal defects (mVSDs) in an acute pig model.Devices currently in use for closure of mVSDs still have their limitations. The deployment of the disks is dependent from the expansion of the stent, which can be associated with problems for sufficient closure of the mVSDs. This was the reason for developing a modified device with only one diskThe device was constructed in a single wire technique with a unique configured retention disk. mVSDs were created in six pigs with a specially designed punch instrument, and subsequently closed with our new device during the same session using a jugular or femoral vein approach. Potential residual shunting volumes were estimate...

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The Gerbode Defect: The Significance of a Left Ventricular to Right Atrial Shunt

Cardiology in the Young — Tue, 27 Oct 2009 13:54:13 +0100

Research ArticlesAngela M. Kelle, Luciana Young, Sunjay Kaushal, C. Elise Duffy, Robert H. Anderson, Carl L. Backer, Cardiology in the Young, Volume 19 Supplement S2 , pp 96-99AbstractBackground The so-called Gerbode ventriculo-atrial defect is a rare defect that permits shunting from the left ventricle to the right atrium. It takes 2 forms, either a deficiency of the atrioventricular membranous septum, or shunting initially through a ventricular septal defect, with atrial shunting occurring through a deficiency in the septal leaflet of the tricuspid valve. In this review, we describe the natural history and outcomes of surgical repair for the variant with shunting through a deficiency at the site of the atrioventricular membranous septum. (Source: Cardiology in the Young)

Transcatheter closure of postoperative residual perimembranous ventricular septal defects.

The Annals of Thoracic Surgery — Tue, 27 Oct 2009 12:28:25 +0100

CONCLUSIONS: Transcatheter closure of postoperative residual PmVSDs is possible without the need for reoperation. The early and midterm prognosis of patients with transcatheter closure is good. PMID: 19853111 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

Mortality associated with adult congenital heart disease: Trends in the US population from 1979 to 2005

American Heart Journal — Sat, 24 Oct 2009 12:49:45 +0100

Conclusions: Patients with congenital heart disease are living longer. Arrhythmia remains the primary contributing cause of death for those with cyanotic lesions. Myocardial infarction is now the leading contributing cause for adults with noncyanotic congenital heart disease consistent with late survival and an increasing impact of acquired heart disease. (Source: American Heart Journal)

Microscopic magnetic resonance in congenital diaphragmatic hernia and associated malformations in rats

Pediatric Surgery International — Fri, 23 Oct 2009 18:53:21 +0100

Conclusions Microscopic magnetic resonance involves refined and expensive equipment but it provides a powerful research tool for the study of CDH and other malformations in rat fetuses. Further work on this area is warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2518-4Authors Montserrat Bret, Hospital Universitario La Paz Department of Radiology Madrid SpainAna Lourdes Luis, Hospital Universitario La Paz Department of Pediatric Surgery Paseo de la Castellana 261 28046 Madrid SpainEmilio Cuesta, Hospital Universitario La Paz Department of Radiology Madrid SpainFederica Pederiva, Hospital Universitario La Paz Department of Pediatric Surgery Paseo de la Castellana 261 28046 Madrid SpainRosa Aras, Hospital Universitario La Paz Departm...

Transcatheter Closure of Postoperative Residual Perimembranous Ventricular Septal Defects [ORIGINAL ARTICLES: PEDIATRIC CARDIAC]

The Annals of Thoracic Surgery — Thu, 22 Oct 2009 18:54:54 +0100

Conclusions Transcatheter closure of postoperative residual PmVSDs is possible without the need for reoperation. The early and midterm prognosis of patients with transcatheter closure is good. (Source: The Annals of Thoracic Surgery)

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Clinical research N-Terminal pro-Brain Natriuretic Peptide in decompansated ventricular septal defect

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:34:46 +0100

Conclusions: NT-proBNP is elevated in VSDs with cardiac decompensation, it is correlated to clinical score and echocardiography parameters. It reflects pressure and volume loads to the pulmonary artery and right ventricle and may help to identify children with VSD and pulmonary hypertension that demands early intervention. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Unifocalization of major aortopulmonary collateral arteries in pulmonary atresia with ventricular septal defect is essential to achieve excellent outcomes irrespective of native pulmonary artery morphology

The Journal of Thoracic and Cardiovascular Surgery — Wed, 21 Oct 2009 00:00:00 +0100

Conclusion: By using a strategy of unifocalization, intrapericardial pulmonary artery reconstruction, and right ventricle-pulmonary artery conduit, excellent long-term survival can be achieved in this group of patients even in the absence of native intrapericardial pulmonary arteries. (Source: The Journal of Thoracic and Cardiovascular Surgery)

An empirically based tool for analyzing mortality associated with congenital heart surgery

The Journal of Thoracic and Cardiovascular Surgery — Mon, 19 Oct 2009 15:20:42 +0100

Conclusion: The proposed risk scores and categories have a high degree of discrimination for predicting mortality and represent an improvement over existing consensus-based methods. Risk models incorporating these measures may be used to compare mortality outcomes across institutions with differing case mixes. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Bland-White-Garland syndrome with ventricular septal defect: late presentation

General Thoracic and Cardiovascular Surgery — Thu, 15 Oct 2009 06:11:57 +0100

Abstract Bland-White-Garland syndrome has been reported generally to occur in an isolated lesion. Here, we report a case of Bland-White-Garland syndrome associated with a ventricular septal defect. Late onset of myocardial ischemia was noted in this patient, which we think is related to increased coronary steal due to regression of pulmonary hypertension caused by narrowing of the ventricular septal defect. At surgery, we temporally occluded the left main coronary trunk to cease the coronary steal phenomenon and augment the left coronary flow. Direct implantation of the left coronary artery and closure of the ventricular septal defect were performed. The postoperative course was excellent with no evidence of myocardial ischemia. Content Type Journal ArticleCategory Case ...

In patients undergoing surgical repair of post-infarction ventricular septal defect, does concomitant revascularization improve prognosis? [Best evidence topic - Cardiac general]

Interactive CardioVascular and Thoracic Surgery — Wed, 14 Oct 2009 16:58:29 +0100

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was ‘In patients undergoing surgical repair of post-infarction ventricular septal defect (VSD), does concomitant revascularization improve prognosis?’. The scientific literature was reviewed by searching Medline, using Ovid interface, from 1950 to April 2009. Four hundred and five papers were found, of which 18 were deemed relevant to the topics. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes, and results of these papers were tabulated. Seven out of 18 papers showed statistical evidence of benefit of concomitant coronary artery bypass grafting (CABG) in patients undergoing surgical repair of VSD. They showed...

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Ministernotomy for repair of congenital cardiac disease [Institutional report - Congenital]

Interactive CardioVascular and Thoracic Surgery — Wed, 14 Oct 2009 16:58:28 +0100

We report our experience with repair of a variety of congenital heart defects utilizing a ministernotomy incision. A ministernotomy was used in 79 patients with a variety of congenital heart diseases from November 2004 to August 2007. Patients included 36 males and 43 females with ages ranging from 1 month to 122 months (median age, 22 months). The weight ranged from 3.5 kg to 40 kg (median weight, 10.9 kg). There were no deaths, and one conversion to full median sternotomy (1/79, 1.3%). The median cardiopulmonary bypass time was 59 min, and median aortic cross-clamp time was 38 min. One patient underwent atrial septal defect (ASD) repair with fibrillatory arrest time of 35 min. The operating time ranged from 103 min to 312 min (median operating time...

Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects

Cardiology in the Young — Wed, 14 Oct 2009 12:51:09 +0100

Research ArticlesHaruka Hamanoue, Sri Endah Rahayuningsih, Yuya Hirahara, Junko Itoh, Utako Yokoyama, Takeshi Mizuguchi, Hirotomo Saitsu, Noriko Miyake, Fumiki Hirahara, Naomichi Matsumoto, Cardiology in the Young, Volume 19 Issue 05 , pp 482-485AbstractWe analysed the GATA binding protein 4 gene, or GATA4, along with the NK2 transcription factor related, locus 5 gene, or NKX2.5, to determine their genetic contribution to 104 sporadic patients in Indonesia with congenitally malformed hearts, 76 cases having atrial septal defect and 28 tetralogy of Fallot. We found only 1 novel mutation of GATA4 in those with atrial septal defecst. Analysis of the genetic background of the parents of the patient showed for the first time that a new mutation of GATA4 can cause sporadic atrial septal defects....

Complete congenital obstruction of a scimitar vein in an infant with severe respiratory failure

Cardiology in the Young — Wed, 14 Oct 2009 12:51:09 +0100

We report an infant of 3 1/2 months with complete obstruction of the venous component of the scimitar syndrome, a large atrial septal defect within the oval fossa, a common left pulmonary vein, and pulmonary hypertension. To the best of our knowledge, ours is the first description of complete congenital obstruction of a scimitar vein. (Source: Cardiology in the Young)

Catheter closure of an atrial septal defect in anatomically corrected malposition with left juxtaposition of atrial appendages

Cardiology in the Young — Wed, 14 Oct 2009 12:51:09 +0100

In this report, I describe the insertion of a device to close an atrial septal defect, as guided by transoesophageal echocardiography. (Source: Cardiology in the Young)

Transesophageal Echocardiography for Device Closure of Atrial Septal Defects: Case Selection, Planning, and Procedural Guidance

Journal of the American College of Cardiology: Cardiovascular Imaging — Mon, 12 Oct 2009 21:01:48 +0100

(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)

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Post-Traumatic Ventricular Septal Defects -- Review of the Literature and a Novel Technique for Percutaneous Closure

Medscape Today Headlines — Mon, 12 Oct 2009 10:09:44 +0100

Closure of a post-traumatic ventricular septal defect is sometimes lifesaving and sometimes unnecessary. When it's needed, here's a new way of doing it. The Journal of Invasive Cardiology (Source: Medscape Today Headlines)

Variation in the Prevalence of Congenital Heart Defects by Maternal Race/Ethnicity and Infant Sex

The Journal of Pediatrics — Mon, 12 Oct 2009 00:00:00 +0100

Conclusions: We found differences in ethnic susceptibilities to CHD by sex, but the cause remains unclear. (Source: The Journal of Pediatrics)

Impact of Occluder Device Type on Success of Percutaneous Closure of Atrial Septal Defects–A Medium-Term Follow-up Study

Journal of Interventional Cardiology — Sun, 11 Oct 2009 23:00:00 +0100

Conclusions: Percutaneous closure of patent foramen ovale or atrial septal defect is a safe procedure with little incidence of peri- and postprocedural complications. There is a significant difference between the Amplatzer[trade], Cardiastar[trade], and Starflex[trade] occluders in regard to complete closure of the defects and annual recurrence of thromboembolic events. (J Interven Cardiol 2009;**:1[ndash]8) (Source: Journal of Interventional Cardiology)

Real-time three-dimensional echocardiography using a matrix probe with live xPlane imaging of the interventricular septum

Ultrasound in Obstetrics and Gynecology — Fri, 09 Oct 2009 23:00:00 +0100

We describe live xPlane imaging, a simple method for the real-time assessment of the in-plane view of the IVS that has the potential to enhance the diagnostic accuracy of fetal cardiac examination. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)