MedWorm: Hypertension

High Blood Pressure Easy to Miss in Children with Kidney Disease-11/20/09

Johns Hopkins Medicine News — Sat, 21 Nov 2009 15:09:46 +0100

Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension – even during doctor’s office visits — increasing a child’s risk for serious heart problems, according to research from Johns Hopkins Children’s Center and other institutions. (Source: Johns Hopkins Medicine News)

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Health News of the Day

Clinical Cases and Images — Sat, 21 Nov 2009 11:10:00 +0100

is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:"The brains of human beings seem built to process stories better than other forms of input. Without numbers, stories are just anecdotes, but without stories, numbers are just dry statistics" http://bit.ly/4u93VJHow Much Do Doctors in Other Countries Make? NYT - http://bit.ly/3DDrz5 - Contrary to expectations, the U.S. doesn't top the list for specialists.75% of Italian and Canadian doctors report patients wait a long time to see specialists, 28% in the U.S. http://bit.ly/2tzz8xMovie Theater Popcorn a Calorie Bomb: A large popcorn tub packs more fat and calories than 2 Big Macs http://bit.ly/...

Sleep apnea may cause heart disease in kidney transplant patients

ScienceDaily Headlines — Sat, 21 Nov 2009 10:00:00 +0100

Sleep apnea is common in individuals who receive a kidney transplant and is associated with increased risk of high blood pressure, heart disease or stroke, according to a new study. (Source: ScienceDaily Headlines)

High Blood Pressure Easy To Miss In Children With Kidney Disease

Health News from Medical News Today — Sat, 21 Nov 2009 09:00:00 +0100

Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension even during doctor's office visits increasing a child's risk for serious heart problems, according to research from Johns Hopkins Children's Center and other institutions. A report of the findings appears online in the Journal of American Society of Nephrology. (Source: Health News from Medical News Today)

High Blood Pressure Easy To Miss In Children With Kidney Disease

Hypertension News From Medical News Today — Sat, 21 Nov 2009 09:00:00 +0100

Heart Disease In Kidney Transplant Patients May Be Caused By Sleep Apnea

Health News from Medical News Today — Sat, 21 Nov 2009 08:00:00 +0100

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Heart Disease In Kidney Transplant Patients May Be Caused By Sleep Apnea

Urology / Nephrology News From Medical News Today — Sat, 21 Nov 2009 08:00:00 +0100

Sleep apnea is common in individuals who receive a kidney transplant and is associated with increased risk of high blood pressure, heart disease or stroke, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). Researchers found that kidney transplant patients are just as likely to have this sleep disorder as dialyzed kidney disease patients who are on the transplant waiting list. (Source: Urology / Nephrology News From Medical News Today)

From pseudotumour cerebri to idiopathic intracranial hypertension.

Practical Neurology — Sat, 21 Nov 2009 02:32:12 +0100

Authors: Pearce JM PMID: 19923117 [PubMed - as supplied by publisher] (Source: Practical Neurology)

[Clinical and therapeutic heterogeneity of cerebral venous thrombosis: a description of a series of 20 cases.]

Revista de Neurologia — Sat, 21 Nov 2009 02:18:35 +0100

CONCLUSIONS. We report a great variety of etiologies and patterns of presentation of CVT. CVT should be suspected in patients with subacute headache, even in outpatients. Nonacute presentation with isolated headache or intracranial hypertension could have better prognosis, requiring a less aggressive therapy. PMID: 19921621 [PubMed - as supplied by publisher] (Source: Revista de Neurologia)

Pregnancy in peri- and postmenopausal women: challenges in management

Menopause International — Sat, 21 Nov 2009 00:53:47 +0100

Pregnancy in peri- and postmenopausal women is associated with an increased risk of complications and represents several challenges in terms of clinical management. Women in these age groups typically fall into one of two distinct groups, those who have conceived following assisted reproductive techniques, using ovum donation and those who have conceived spontaneously. While both have age in common, they differ in terms of additional risk factors. Recipients of assisted reproductive technologies have pregnancy risks associated with that treatment, but are at lower risks of a fetus affected by aneuploidy. Furthermore, they have been rigorously screened for medical complications, but are more likely to be primiparous and have multiple pregnancies. In contrast, women conceiving spontaneously ...

Tie2-mediated loss of peroxisome proliferator-activated receptor-{gamma} in mice causes PDGF receptor-{beta}-dependent pulmonary arterial muscularization

AJP: Lung Cellular and Molecular Physiology — Sat, 21 Nov 2009 00:09:00 +0100

Peroxisome proliferator-activated receptor (PPAR)- is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion of PPAR in smooth muscle cells (SMCs) of transgenic mice results in PAH. However, the sequelae of loss of PPAR in PA endothelial cells (ECs) are unknown. Therefore, we bred Tie2-Cre mice with PPARflox/flox mice to induce EC loss of PPAR (Tie2 PPAR–/–), and we assessed PAH by right ventricular systolic pressure (RVSP), RV hypertrophy (RVH), and muscularized distal PAs in room air (RA), after chronic hypoxia (CH), and after 4 wk of recovery in RA (Rec-RA). The Tie2 PPAR–/– mice developed spontaneous PAH in RA with increased RVSP, RVH, and muscularized PAs vs. wild type (WT); both genotypes exhibited a similar d...

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Inhaled nitric oxide improves lung structure and pulmonary hypertension in a model of bleomycin-induced bronchopulmonary dysplasia in neonatal rats

AJP: Lung Cellular and Molecular Physiology — Sat, 21 Nov 2009 00:09:00 +0100

Whether inhaled nitric oxide (iNO) prevents the development of bronchopulmonary dysplasia (BPD) in premature infants is controversial. In adult rats, bleomycin (Bleo) induces lung fibrosis and pulmonary hypertension, but the effects of Bleo on the developing lung and iNO treatment on Bleo-induced neonatal lung injury are uncertain. Therefore, we sought to determine whether early and prolonged iNO therapy attenuates changes of pulmonary vascular and alveolar structure in a model of BPD induced by Bleo treatment of neonatal rats. Sprague-Dawley rat pups were treated with Bleo (1 mg/kg ip daily) or vehicle (controls) from day 2 to 10, followed by recovery from day 11 to 19. Treatment groups received early (days 2–10), late (days 11–19), or prolonged iNO therapy (10 ppm; days 2&nda...

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

AJP: Lung Cellular and Molecular Physiology — Sat, 21 Nov 2009 00:09:00 +0100

Vascular remodeling and smooth muscle cell proliferation are hallmark pathogenic features of pulmonary artery hypertension (PAH). Alterations in the metabolism of l-arginine via arginase and nitric oxide synthase play a critical role in the endothelial dysfunction seen in PAH. l-arginine metabolism by arginase produces l-ornithine and urea. l-ornithine is a precursor for polyamine and proline synthesis, ultimately leading to an increase in cellular proliferation. Given the integral role of the smooth muscle layer in the pathogenesis of hypoxia-induced PAH, we hypothesized that hypoxia would increase cellular proliferation via arginase induction in human pulmonary artery smooth muscle cells (hPASMC). We found that arginase II mRNA and protein expression were significantly increased in cultu...

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

AJP: Lung Cellular and Molecular Physiology — Sat, 21 Nov 2009 00:08:59 +0100

At present, six groups of chronic pulmonary hypertension (PH) are described. Among these, group 1 (and 1') comprises a group of diverse diseases termed pulmonary arterial hypertension (PAH) that have several pathophysiological, histological, and prognostic features in common. PAH is a particularly severe and progressive form of PH that frequently leads to right heart failure and premature death. The diagnosis of PAH must include a series of defined clinical parameters, which extend beyond mere elevations in pulmonary arterial pressures and include precapillary PH, pulmonary hypertensive arteriopathy (usually with plexiform lesions), slow clinical onset (months or years), and a chronic time course (years) characterized by progressive deterioration. What appears to distinguish PAH from other...

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall

AJP: Lung Cellular and Molecular Physiology — Sat, 21 Nov 2009 00:08:59 +0100

All forms of chronic pulmonary hypertension (PH) are characterized by structural remodeling of the pulmonary artery (PA) media, a process previously attributed solely to changes in the phenotype of resident smooth muscle cells (SMC). However, recent experimental evidence in both systemic and pulmonary circulations suggests that other cell types, including circulating and local progenitors, contribute significantly to this process. The goal of this study was to determine if hypoxia-induced remodeling of distal PA (dPA) media involves the emergence of cells with phenotypic and functional characteristics distinct from those of resident dPA SMC and fibroblasts. In vivo, in contrast to the phenotypically uniform SMC composition of dPA media in control calves, the remodeled dPA media of neonatal...

The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6

AJP: Regulatory, Integrative and Comparative Physiology — Fri, 20 Nov 2009 23:31:39 +0100

This study determined whether that MR action is sustained with chronic ANG II infusion and whether it plays a role in mediating ANG II hypertension. ANG II infusion (90 ng/min) increased plasma IL-6 from 1.6 ± 0.6 to 22.7 ± 2.2 and 19.9 ± 3.2 pg/ml on days 7 and 14, respectively, and chronic MR blockade with spironolactone attenuated that only at day 7 (7.2 ± 2.2 pg/ml). ANG II increased MAP (19 h/day with telemetry) ~40 mmHg, but in ANG II+spironolactone mice (25 or 50 mg·kg–1·day–1), mean arterial pressure (MAP) was not significantly different despite a tendency for lower pressure the first 6 days. To isolate further the mineralocorticoid link to IL-6 and blood pressure, DOCA-salt hypertension was induced in IL-6 KO and wild-type (WT)...

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Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:08 +0100

CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen. PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Highlights.

American Journal of Hypertension — Fri, 20 Nov 2009 20:12:10 +0100

Authors: PMID: 19924115 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)

Aldosterone and Hypertension in African Americans.

American Journal of Hypertension — Fri, 20 Nov 2009 20:12:07 +0100

Authors: Ku E, Campese VM PMID: 19924116 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)

Abstracts from the Chinese Journal of Hypertension.

American Journal of Hypertension — Fri, 20 Nov 2009 20:12:05 +0100

Authors: PMID: 19924117 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)

QUESTION 2. Does nephrocalcinosis in ex-premature babies cause long-term renal problems?

Archives of Disease in Childhood — Fri, 20 Nov 2009 18:02:28 +0100

(Source: Archives of Disease in Childhood)

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Blood pressure in children aged 4-8 years: comparison of Omron HEM 711 and sphygmomanometer blood pressure measurements

Archives of Disease in Childhood — Fri, 20 Nov 2009 18:02:26 +0100

Conclusions: Children were equally distributed in their preference for BP device. There was a wide variation between the two methods of BP measurement, which suggests that comparison of automated BP measurements with normative data obtained by sphygmomanometer is not valid. (Source: Archives of Disease in Childhood)

Endothelin-1, big endothelin-1, and nitric oxide in patients with chronic renal disease and hypertension

Journal of Clinical Laboratory Analysis — Fri, 20 Nov 2009 16:25:53 +0100

The complex pathogenesis of chronic renal disease (CRD) depends on endothelin (ET) axis (ETs and ET receptors) and nitric oxide (NO) because of their vasoactive effects and their role in general modulation of vascular homeostasis. Various renal cells synthesize ETs and NO that play a significant role in renal hemodynamics as well as in water and salt excretion via urine. ET-1 is a strong vasoconstrictor. Besides its vasoactive effects, ET-1 modulates mitosis and apoptosis in a cell type-dependent manner, and may play an important role in CRD pathogenesis. The aims of this study were to emphasize the role and interactions of ET-1, Big ET-1, and NO in CRD. Concentrations of these vasoactive molecules were measured in plasma/serum and/or urine of 57 patients with diabetic nephropathy (subgrou...

A prospective, randomized, crossover pilot study of inhaled nitric oxide versus inhaled prostacyclin in heart transplant and lung transplant recipients

The Journal of Thoracic and Cardiovascular Surgery — Fri, 20 Nov 2009 16:22:52 +0100

Conclusion: In heart transplant and lung transplant recipients, nitric oxide and prostacyclin similarly reduce pulmonary artery pressures and central venous pressure, and improve cardiac index and mixed venous oxygen saturation. Inhaled prostacyclin may offer an alternative to nitric oxide in the treatment of pulmonary hypertension in thoracic transplantation. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Research Library: Notch3 signaling promotes the development of pulmonary arterial hypertension

Nature Signaling Update — Fri, 20 Nov 2009 15:16:38 +0100

(Source: Nature Signaling Update)

FDA Approves Intravenous Formulation Of Pfizer's Revatio(R) (Sildenafil) For The Treatment Of Pulmonary Arterial Hypertension

HSMN NewsFeed — Fri, 20 Nov 2009 14:57:46 +0100

Revatio is the Only Treatment in Its Class with Both Oral and Intravenous Formulations NEW YORK--(HSMN NewsFeed)--Pfizer announced today that the U.S. Food and Drug Administration (FDA) has approved Revatio(R) (sildenafil) Injection, an intravenous form... Biopharmaceuticals, FDAPfizer, Revatio, sildenafil, phosphodiesterase, pulmonary arterial hypertension (Source: HSMN NewsFeed)

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The association of continuity of care on the diagnosis of hypertension in children and adolescents

Journal of Child Health Care — Fri, 20 Nov 2009 14:44:35 +0100

Hypertension among pediatric patients is an underdiagnosed condition. As continuity of care has been found to increase quality of pediatric care, we undertook this study to assess effect of continuity on diagnosis of pediatric hypertension. This is a retrospective analysis of 774 hypertensive patients, ages 3—18 years between June 1999 and October 2007 within the MetroHealth System in northeastern Ohio. The proportion of hypertensive patients diagnosed was assessed using coding within the electronic medical record. Continuity was assessed using the usual provider of care, defined as the number of visits to the most frequent provider divided by the total number of visits in the study period. Overall continuity did not have a statistically significant association with diagnosis (OR 0.7...

Functional Roles of Human Kallikrein-related Peptidases [Thematic Minireview Series]

Journal of Biological Chemistry — Fri, 20 Nov 2009 14:36:52 +0100

Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the "KLK activome." However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative in vivo. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pa...

Common carotid intima-media thickness in acute ischemic stroke: A case control study

Neurology India — Fri, 20 Nov 2009 14:36:08 +0100

In this study the CIMT was independently associated with increasing age and with the presence of carotid plaques. (Source: Neurology India)

FDA Approves Intravenous Formulation Of Pfizer's Revatio (Sildenafil) For The Treatment Of Pulmonary Arterial Hypertension

Drugs.com - New Drug Approvals — Fri, 20 Nov 2009 14:03:42 +0100

Revatio is the Only Treatment in Its Class with Both Oral and Intravenous Formulations NEW YORK--(BUSINESS WIRE)--Nov 20, 2009 - Pfizer announced today that the U.S. Food and Drug Administration (FDA) has approved Revatio (sildenafil) Injection,... (Source: Drugs.com - New Drug Approvals)

Prevalence of high blood pressure levels and associated factors among adults in Southern Brazil

Arquivos Brasileiros de Cardiologia — Fri, 20 Nov 2009 13:54:09 +0100

CONCLUSIONS: One third of the assessed adults presented high blood pressure levels, similar to most of the Brazilian findings. Factors that can be prevented, such as overweight, obesity and self-reported diabetes were associated with high blood pressure levels. (Source: Arquivos Brasileiros de Cardiologia)

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Exercise prevents cardiometabolic alterations induced by chronic use of glucocorticoids

Arquivos Brasileiros de Cardiologia — Fri, 20 Nov 2009 13:54:09 +0100

CONCLUSION: The aerobic exercise training have a protective effect against the cardiometabolic alterations induced by the chronic use of glucocorticoids. (Source: Arquivos Brasileiros de Cardiologia)

Arterial hypertension and physical activity

Arquivos Brasileiros de Cardiologia — Fri, 20 Nov 2009 13:54:09 +0100

A terapia de ressincronização cardíaca (TRC) tem sido uma opção efetiva nos pacientes com insuficiência cardíaca avançada. No entanto 20% a 30% dos pacientes não apresentam benefícios nessa terapêutica. Critérios clínicos, eletrocardiográficos e ecocardiográficos têm sido estudados na tentativa de selecionar os pacientes que serão beneficiados com a ressincronização cardíaca, mas o ecocardiograma tem papel importante tanto na seleção quanto na avaliação e otimização dessa terapêutica. O objetivo desta revisão é descrever os principais parâmetros ecocardiográficos utilizados na avaliação da terapia de ressincronização cardíaca. (Source: Arquivos Brasileiros de Cardiologia)

Kidney Transplant, Sleep Disorder May Add Up to Trouble

MedicineNet High Blood Pressure General — Fri, 20 Nov 2009 07:00:00 +0100

Title: Kidney Transplant, Sleep Disorder May Add Up to TroubleCategory: Health NewsCreated: 11/19/2009 10:10:00 PMLast Editorial Review: 11/20/2009 (Source: MedicineNet High Blood Pressure General)

High blood pressure easy to miss in children with kidney disease

EurekAlert! - Medicine and Health — Fri, 20 Nov 2009 05:00:00 +0100

(Johns Hopkins Medical Institutions) Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension -- even during doctor's office visits -- increasing a child's risk for serious heart problems, according to research from Johns Hopkins Children's Center and other institutions. A report of the findings appears online in the Journal of American Society of Nephrology. (Source: EurekAlert! - Medicine and Health)

Artificial Sweetener May Lower Blood Pressure

WebMD Health — Fri, 20 Nov 2009 05:00:00 +0100

An artificial sweetener that's been shown to help people shed unwanted pounds may also lower blood pressure and cholesterol levels in people with mild or borderline high blood pressure, Chinese researchers report. (Source: WebMD Health)

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[Articles] Premature deaths attributable to blood pressure in China: a prospective cohort study

LANCET — Fri, 20 Nov 2009 00:00:00 +0100

Hypertension is a major global-health challenge because of its high prevalence and concomitant risks of cardiovascular disease. We estimated premature deaths attributable to increased blood pressure in China. (Source: LANCET)

Journal Scan: A Selective Endothelin-Receptor Antagonist to Reduce Blood Pressure in Patients With Treatment-Resistant Hypertension: A Randomised, Double-Blind, Placebo-Controlled Trial (Lancet 2009;374:1423-1431.)

Cardiosource — Fri, 20 Nov 2009 00:00:00 +0100

A randomized, double-blind study was undertaken in 117 sites in North and South America, Europe, New Zealand, and Australia. A total of 379 patients with systolic blood pressure of 140 mm Hg or more (≥130 mm Hg if patient had diabetes or chronic kidney disease) who were receiving at least thre. . . (Source: Cardiosource)

Sleep Apnea in Kidney Transplant Patients Assessed

Modern Medicine — Fri, 20 Nov 2009 00:00:00 +0100

The prevalence of obstructive sleep apnea in patients with kidney disease who underwent or are awaiting transplant is similar, but transplant recipients with the sleep disorder may be at higher risk for hypertension, according to a study published online Nov. 18 in the Clinical Journal of the American Society of Nephrology. (Source: Modern Medicine)

Kidney Volume and Albuminuria as Markers of Birth Weight-Blood Pressure Relationship in Essential Hypertension

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Kidney Blood Press Res 2009;32:399-404 (DOI:10.1159/000260041) (Source: Karger Publishers)

AHA: Diuretics Measure Up to Newer BP Drugs (CME/CE)

MedPage Today Cardiovascular — Thu, 19 Nov 2009 17:08:07 +0100

ORLANDO (MedPage Today) -- Over the long term, diuretics fight hypertension as well as newer, more expensive blood pressure medications, researchers said here. (Source: MedPage Today Cardiovascular)

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Don't lose your head over beer claim

NHS News Feed — Thu, 19 Nov 2009 17:03:00 +0100

Conclusion Although this study demonstrated a link between higher alcohol intake and reduced CHD risk, it is has several limitations. Therefore, it cannot be assumed that high levels of alcohol consumption lower the risk of CHD. People are advised not to exceed the recommended daily limits of 2-3 units a day for women and 3-4 units a day for men. Importantly, the study did not take into account any other adverse effects of alcohol, such as the increased risk of liver disease, obesity, pancreatic diseases, certain cancers, possible addiction, depression, accidental injury or reduced judgement in social situations. Further limitations to this research include the following: Asking someone to recall daily or weekly alcohol intake in the previous 12 months is likely to involve a high degree...

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

Blood — Thu, 19 Nov 2009 17:02:19 +0100

In conclusion, increase in hemoglobin F in sickle cell disease may be associated with relatively lower tissue oxygen delivery as reflected in higher erythropoietin concentration. Greater levels of erythropoietin or hemoglobin F were independently associated with higher tricuspid regurgitation velocity after adjustment for degree of hemolysis, suggesting an independent relationship of hypoxia with higher systolic pulmonary artery pressure. The hemolysis-lowering and hemoglobin F–augmenting effects of hydroxyurea may exert countervailing influences on pulmonary blood pressure in sickle cell disease. (Source: Blood)

Health issues in middle age can lead to dementia

Reuters: Health — Thu, 19 Nov 2009 16:39:45 +0100

NEW YORK (Reuters Health) - People who smoke or who have high blood pressure or diabetes in middle age are more likely to develop dementia, a new study has found. (Source: Reuters: Health)

The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease

European Journal of Heart Failure — Thu, 19 Nov 2009 16:06:20 +0100

Conclusion Heart failure is a strong independent predictor of all-cause mortality in patients with a diagnosis of COPD. (Source: European Journal of Heart Failure)

Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve

European Journal of Heart Failure — Thu, 19 Nov 2009 16:06:19 +0100

Conclusion Food-restriction in obese diabetic mice leads to improved cardiac performance by diminishing cardiac load and by ameliorating the intrinsic contractile properties of the cardiac muscle. However, cardiac reserve under dobutamine stimulation did not increase. (Source: European Journal of Heart Failure)

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Normal systolic blood pressure and risk of heart failure in US male physicians

European Journal of Heart Failure — Thu, 19 Nov 2009 16:06:19 +0100

Conclusion Our findings suggest a linear relationship between normotensive SBP and HF risk. Strategies to prevent HF, such as lifestyle modification, should be emphasized across all blood pressure ranges. (Source: European Journal of Heart Failure)

Sleep Apnea and Atrial Fibrillation: The Autonomic Link⁎

Journal of the American College of Cardiology — Thu, 19 Nov 2009 13:52:16 +0100

The intuitive and postulated links () between the established association of obstructive sleep apnea with atrial fibrillation (AF) are hypertension, diastolic dysfunction, and the resultant long-term atrial remodeling (). However, studies suggest that the relationship between sleep apnea and AF is independent of hypertension, cardiac function, or body mass index. Further, untreated sleep apnea doubles the risk of AF recurrence within 12 months of cardioversion independent of other risk factors (). Thus, is the relationship between sleep apnea and AF an epiphenomenon, or is it truly causative and the linking mechanism is simply not yet explained? (Source: Journal of the American College of Cardiology)

A Meta-Analysis of the Mechanism of Blood Pressure Change With Aging

Journal of the American College of Cardiology — Thu, 19 Nov 2009 13:52:16 +0100

Conclusions: These findings challenge the current consensus view that a shift in timing of wave reflection significantly contributes to the changes in the BP waveform with aging. We should re-evaluate the mechanisms of BP elevation in aging. (Source: Journal of the American College of Cardiology)

ED Drug Improves Heart's Pumping Action In Young Patients With Single-Ventricle Disease

Health News from Medical News Today — Thu, 19 Nov 2009 09:00:00 +0100

Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia. (Source: Health News from Medical News Today)

ED Drug Improves Heart's Pumping Action In Young Patients With Single-Ventricle Disease

Cardiovascular / Cardiology News From Medical News Today — Thu, 19 Nov 2009 09:00:00 +0100

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Highlights Of NHLBI-Supported Research Presented At American Heart Association's Scientific Sessions

Health News from Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

Highlights Of NHLBI-Supported Research Presented At American Heart Association's Scientific Sessions

Cardiovascular / Cardiology News From Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

Diuretics Still Best Treatment for High Blood Pressure

MedicineNet Cholesterol General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Diuretics Still Best Treatment for High Blood PressureCategory: Health NewsCreated: 11/18/2009 2:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Cholesterol General)

Diuretics Still Best Treatment for High Blood Pressure

MedicineNet Heart General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Diuretics Still Best Treatment for High Blood PressureCategory: Health NewsCreated: 11/18/2009 2:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Heart General)

Dual Heart Tests Best for Young Athletes

MedicineNet High Blood Pressure General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Dual Heart Tests Best for Young AthletesCategory: Health NewsCreated: 11/19/2009 10:47:00 AMLast Editorial Review: 11/19/2009 10:47:49 AM (Source: MedicineNet High Blood Pressure General)

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No Increased Pregnancy Risk for MS Patients

MedicineNet High Blood Pressure General — Thu, 19 Nov 2009 07:00:00 +0100

Title: No Increased Pregnancy Risk for MS PatientsCategory: Health NewsCreated: 11/19/2009 10:42:00 AMLast Editorial Review: 11/19/2009 10:42:22 AM (Source: MedicineNet High Blood Pressure General)

Diuretics Still Best Treatment for High Blood Pressure

MedicineNet High Blood Pressure General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Diuretics Still Best Treatment for High Blood PressureCategory: Health NewsCreated: 11/18/2009 2:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet High Blood Pressure General)

Lifelong Exercise Keeps Seniors Young at Heart

MedicineNet High Blood Pressure General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Lifelong Exercise Keeps Seniors Young at HeartCategory: Health NewsCreated: 11/18/2009 4:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet High Blood Pressure General)

Diuretics Still Best Treatment for High Blood Pressure

MedicineNet Senior Health General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Diuretics Still Best Treatment for High Blood PressureCategory: Health NewsCreated: 11/18/2009 2:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Senior Health General)

Transcendental meditation for college students

Medicineworld.org: New Article Alert — Thu, 19 Nov 2009 06:04:43 +0100

The Transcendental Meditation technique appears to be an effective method to reduce blood pressure, anxiety, depression, and anger among at-risk college students, as per a newly released study to be reported in the American Journal of Hypertension, December 2009. "The Transcendental Meditation Program, a widely-used standardized program to reduce stress, showed significant decreases in blood pressure and improved mental health in young adults at risk for hypertension," said David Haaga, PhD, co-author of the study and professor of psychology at American University in Washington, D.C........ (Source: Medicineworld.org: New Article Alert)

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Review: Obesity and Alzheimer's Disease: A Link Between Body Weight and Cognitive Function in Old Age

American Journal of Alzheimer's Disease and Other Dementias — Thu, 19 Nov 2009 01:03:27 +0100

Obesity is now a global health hazard. It not only predisposes to an array of risk factors leading to increased morbidity and mortality amongst adults but it also has a major negative impact on children’s health. The deleterious effects of obesity on cardiovascular system have now been well acknowledged. It causes insulin resistance that in turn leads to diabetes, hypertension and cardiovascular abnormalities. The vascular effects of obesity may have a role in the development of a rapidly growing disease of late life, Alzheimer’s disease. The precise mechanisms of the association between adiposity and impairment of cognitive performance remain to be elucidated. However, negative impact of obesity on cognitive function may be, at least in part, due to vascular defects, impaired ...

Drug for erectile dysfunction improves heart function in young heart-disease patients

ScienceDaily Headlines — Thu, 19 Nov 2009 01:00:00 +0100

After treatment with sildenafil, heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation. Sildenafil is a drug commonly used to treat erectile dysfunction and pulmonary hypertension. (Source: ScienceDaily Headlines)

Study Finds Link between Preeclampsia and Reduced Thyroid Function

MedlinePlus Health News — Thu, 19 Nov 2009 00:47:32 +0100

Source: National Institute of Child Health and Human Development Related MedlinePlus Topics: High Blood Pressure in Pregnancy, Thyroid Diseases (Source: MedlinePlus Health News)

Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea.

Sleep and Breathing — Thu, 19 Nov 2009 00:00:00 +0100

CONCLUSIONS: In patients showing similar prevalence of major cardiovascular risk factors and cardio-metabolic therapies, differing for the presence or absence of OSA, cytokine productions from PBMC and PMN were similar and were not modified during cPAP therapy. Studies designed to investigate OSA-associated inflammation should carefully match the control group subjects. PMID: 19924457 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)

Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathway

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)

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What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea

Liver International — Thu, 19 Nov 2009 00:00:00 +0100

To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of (Source: Liver International)

Age-Related Changes in General and Sexual Health in Middle-Aged and Older Men: Results from the European Male Ageing Study (EMAS)

The Journal of Sexual Medicine — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion. Sexual health declined while concomitant morbidities increased in European men as a function of age. The burden of general and sexual health is higher in transitional countries, emphasizing the need to develop more effective strategies to promote healthy aging for men in these countries. Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW, Pendleton N, Bartfai G, Boonen S, Casanueva FF, Finn JD, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Punab M, Silman AJ, Vanderschueren D, Wu FCW, and EMAS Study Group. Age-related changes in general and sexual health in middle-aged and older men: Results from the European Male Ageing Study (EMAS). J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)

Cediranib, an Oral Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Is an Active Drug in Recurrent Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer [Gynecologic Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion Cediranib has activity in recurrent EOC, tubal cancer, and peritoneal cancer with predictable toxicities observed with other TKIs. (Source: Journal of Clinical Oncology)

Dose Finding and Early Efficacy Study of Gemcitabine Plus Capecitabine in Combination With Bevacizumab Plus Erlotinib in Advanced Pancreatic Cancer [Gastrointestinal Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:36 +0100

Conclusion The maximum-tolerated dose of capecitabine was 1,660 mg/m2. The recommended capecitabine dose in this cytotoxic doublet/biologic doublet regimen is 1,440 mg/m2; this regimen is under evaluation in an ongoing phase II study. (Source: Journal of Clinical Oncology)

Meditation may lower BP and college stressors

Reuters: Health — Wed, 18 Nov 2009 21:20:26 +0100

NEW YORK (Reuters Health) - If the stresses of college have put you at risk for high blood pressure, try transcendental meditation. (Source: Reuters: Health)

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Meditation May Lower Blood Pressure and College Stressors

MedlinePlus Health News — Wed, 18 Nov 2009 21:20:26 +0100

If the stresses of college have put you at risk for high blood pressure, try transcendental meditation. Source: Reuters Health Related MedlinePlus Topics: Complementary and Alternative Medicine, High Blood Pressure, Teen Health (Source: MedlinePlus Health News)

Diuretics Still Best Treatment for High Blood Pressure

MedlinePlus Health News — Wed, 18 Nov 2009 19:00:00 +0100

Long-term comparison study finds chlorthalidone most likely to prevent heart failure, stroke Source: HealthDay Related MedlinePlus Topics: Blood Pressure Medicines, High Blood Pressure, Seniors' Health (Source: MedlinePlus Health News)

Highlights of NHLBI-Supported Research Presented at American Heart Association's Scientific Sessions

National Institutes of Health (NIH) News Releases — Wed, 18 Nov 2009 18:11:00 +0100

New education strategies for better controlling hypertension and research suggesting a possible link between short-term and long-term exposure to air pollution and increased risk of constricted blood vessels are among the research highlights from studies supported by the National Heart, Lung, and Blood Institute (NHLBI) at the American Heart Association's 2009 Scientific Sessions in Orlando held Nov. 14–18. Other NHLBI-supported studies to be presented focus on the detection of fat in the tissue layer surrounding the heart, and a comparison of surgical strategies to treat a heart defect in newborns. The NHLBI is part of the National Institutes of Health. (Source: National Institutes of Health (NIH) News Releases)

Ethnic inequalities in access to and outcomes of healthcare: analysis of the Health Survey for England

Journal of Epidemiology and Community Health — Wed, 18 Nov 2009 18:04:48 +0100

Conclusion: Ethnic inequalities in access to healthcare and the outcomes of care for three conditions (hypertension, raised cholesterol and diabetes), for which treatment is largely provided in primary care, appear to be minimal in England. Although inequalities may exist for other conditions and other healthcare settings, particularly internationally, the implication is that ethnic inequalities in healthcare are minimal within NHS primary care. (Source: Journal of Epidemiology and Community Health)

Therapeutic options for systemic right ventricular failure

Heart — Wed, 18 Nov 2009 18:01:51 +0100

(Source: Heart)

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Low triglycerides are risk factor for hemorrhagic stroke

MedWire News - Lipidology — Wed, 18 Nov 2009 16:37:42 +0100

Low triglyceride levels are associated with an increased risk for hemorrhagic stroke, particularly in men and those with hypertension or low lipid levels, a large French population-based study has found. (Source: MedWire News - Lipidology)

Serious Errors in Prostacyclin Administration Not Uncommon

Medscape Cardiology Headlines — Wed, 18 Nov 2009 16:09:45 +0100

Investigators call for new treatment guidelines for the administration of prostacyclin for pulmonary arterial hypertension to reduce the high error rate associated with the drug. Medscape Medical News (Source: Medscape Cardiology Headlines)

College Stress

MedlinePlus Health News — Wed, 18 Nov 2009 15:47:31 +0100

Source: HealthDay Related MedlinePlus Topics: Complementary and Alternative Medicine, High Blood Pressure, Stress, Teen Health, Teen Mental Health (Source: MedlinePlus Health News)

The Current State of Endovascular Therapy in the Evaluation and Management of Renovascular Disease

Seminars in Interventional Radiology — Wed, 18 Nov 2009 15:26:23 +0100

Semin intervent Radiol 2009; 26: 333-344DOI: 10.1055/s-0029-1242202ABSTRACTHypertension is the most common reason for physician office visits among nonpregnant adults in the United States; up to one-third of Americans over the age of 18 have been diagnosed with hypertension. Patients with physiologically significant renal artery stenosis often go unnoticed because hypertension can often be well controlled with antihypertensive medications. As a result, screening for renovascular causes of hypertension is rarely done. However, the likelihood of renovascular disease increases in patients with acute, severe, or refractory hypertension and should be explored in patients who fall into these categories. Renovascular disease is a crucial consideration in the management of hypertension due to its ...

A Rare Coronary Anomaly

Heart, Lung & Circulation — Wed, 18 Nov 2009 13:53:45 +0100

An 84-year-old woman with hypertension and recent onset stable angina underwent coronary angiography after a myocardial perfusion scan demonstrated anterior ischaemia. This revealed a single coronary artery ostium in the right sinus of Valsalva from which arose the left anterior descending (LAD) artery and right coronary artery (RCA). The LAD was found to take a route to the left in a retroaortic fashion (dorsal) before assuming its usual position in the anterior interventricular groove. It had a proximal 70% atheromatous stenosis. The RCA traversed the atrioventricular groove giving rise to a posterior descending branch at the crux before continuing as the circumflex coronary artery (Cx). Accompanying images are of conventional coronary angiography (left anterior oblique caudal view), 64-...

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Sun Pharma subsi gets USFDA nod for anti-hypertension drug

The Economic Times Healthcare and Biotech News — Wed, 18 Nov 2009 13:35:45 +0100

Drug firm Sun Pharmaceutical Industries on Wednesday said that its subsidiary, has received US Drug regulator approval for anti-hypertension drug. (Source: The Economic Times Healthcare and Biotech News)

Sun Pharma subsi gets USFDA nod for anti-hypertension drug

The Economic Times Healthcare and Biotech News — Wed, 18 Nov 2009 13:35:45 +0100

At-Risk College Students Reduce HBP, Anxiety, Depression Through Transcendental Meditation

Anxiety News From Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

The Transcendental Meditation technique may be an effective method to reduce blood pressure, anxiety, depression, and anger among at-risk college students, according to a new study to be published in the American Journal of Hypertension, December 2009. (Source: Anxiety News From Medical News Today)

At-Risk College Students Reduce HBP, Anxiety, Depression Through Transcendental Meditation

Health News from Medical News Today — Wed, 18 Nov 2009 12:00:00 +0100

Pre-eclampsia linked to thyroid

NHS News Feed — Wed, 18 Nov 2009 11:21:00 +0100

Conclusion This well-conducted research used two separate studies to examine whether pre-eclampsia during pregnancy affects thyroid function. Although both studies found a clear link between pre-eclampsia and blood tests that indicated an underactive thyroid, many questions remain unanswered. Principally, it is unclear whether blood test results that indicated an underactive thyroid were associated with any signs or symptoms of disease. While women had altered levels of one of the thyroid hormones tested, few women were found to have abnormal levels of both. Abnormal levels of just one hormone does not necessarily suggest clinical hypothyroidism. It is not known whether thyroid function went back to normal following birth, whether it persisted and for how long, or whether any hypothy...

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New Consortium Paves The Way For Improved Treatment Of Hypertension And Associated Vascular Complications

Health News from Medical News Today — Wed, 18 Nov 2009 11:00:00 +0100

Top Institute Pharma (TI Pharma) has formed a consortium with Actelion Pharmaceuticals Ltd, Erasmus Medical Centre and Maastricht University to define new modalities for the treatment of hypertension (high blood pressure) and associated vascular complications such as heart and kidney failure, myocardial infarction and stroke. (Source: Health News from Medical News Today)

New Consortium Paves The Way For Improved Treatment Of Hypertension And Associated Vascular Complications

Hypertension News From Medical News Today — Wed, 18 Nov 2009 11:00:00 +0100

New Study Heralds Use Of Blood Biomarkers To Predict Preeclampsia

Hypertension News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

A new study that examines the value of maternal blood biomarkers will help identify and monitor patients at risk of developing preeclampsia and is set to change the way expectant mothers are cared for in prenatal clinics around the world. (Source: Hypertension News From Medical News Today)

Evaluating the Community Health Legacy of WWI Chemical Weapons Testing

Journal of Community Health — Wed, 18 Nov 2009 09:29:49 +0100

Abstract Spring Valley, Washington, DC, was built over a World War I chemical weapons development site. Testing activities caused wide dispersal of arsenic in soil and waste disposal resulted in localized subsurface contamination. Spring Valley presents an interesting case study, a contaminated physical environment, but a strongly health-protective social environment. To address a possible “healthy community” bias we selected a nearby comparison community with similar health-protective characteristics. Our study included a community health assessment, a spatial analysis of disease clustering and a chemical hazard assessment. Community health in Spring Valley is good. Rates of major causes of mortality and incidence of selected cancers are 20–70% lower than the nation...

LA Biomed Study Finds Medication Improves Health Of Patients With Pulmonary Arterial Hypertension

Health News from Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

In one of the few studies of the long-term effects of medication in the treatment of pulmonary arterial hypertension (PAH) disease, a team of researchers found the health and exercise capacity of PAH patients improved after two years of treatment with ambrisentan, according to a study published in the current edition of the Journal of the American College of Cardiology. (Source: Health News from Medical News Today)

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LA Biomed Study Finds Medication Improves Health Of Patients With Pulmonary Arterial Hypertension

Cardiovascular / Cardiology News From Medical News Today — Wed, 18 Nov 2009 09:00:00 +0100

Incidence of High Cholesterol Drops in U.S.

MedicineNet High Blood Pressure General — Wed, 18 Nov 2009 07:00:00 +0100

Title: Incidence of High Cholesterol Drops in U.S.Category: Health NewsCreated: 11/17/2009 4:10:00 PMLast Editorial Review: 11/18/2009 (Source: MedicineNet High Blood Pressure General)

Obesity Rolling Back Gains in Heart Health

MedicineNet High Blood Pressure General — Wed, 18 Nov 2009 07:00:00 +0100

Title: Obesity Rolling Back Gains in Heart HealthCategory: Health NewsCreated: 11/17/2009 4:10:00 PMLast Editorial Review: 11/18/2009 (Source: MedicineNet High Blood Pressure General)

Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?

Biochemical Society Transactions — Wed, 18 Nov 2009 05:01:46 +0100

Authors: Ahmed A, Cudmore MJ Pre-eclampsia, a pregnancy-specific multi-organ syndrome characterized by widespread endothelial damage, is a new risk factor for cardiovascular disease. No therapies exist to prevent or treat this condition, even to achieve a modest improvement in pregnancy length or birth weight. Co-administration of soluble VEGFR-1 [VEGF (vascular endothelial growth factor) receptor-1; more commonly known as sFlt-1 (soluble Fms-like tyrosine kinase-1)] and sEng (soluble endoglin) to pregnant rats elicits severe pre-eclampsia-like symptoms. These two anti-angiogenic factors are increased dramatically prior to the clinical onset of pre-eclampsia and are quite possibly the 'final common pathway' responsible for the accompanying signs of hypertension and proteinuria as they ...

At-risk college students reduce HBP, anxiety, depression through Transcendental Meditation

EurekAlert! - Social and Behavioral Science — Wed, 18 Nov 2009 05:00:00 +0100

(Maharishi University of Management) The Transcendental Meditation technique, a widely used standardized program to reduce stress, was an effective method to reduce blood pressure, anxiety, depression and anger among at-risk college students, according to a new study to be published in the December issue of the American Journal of Hypertension. The study, conducted at American University in Washington, D.C., reported that students at risk for developing hypertension, showed significant improvements in blood pressure, psychological distress and coping. (Source: EurekAlert! - Social and Behavioral Science)

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Drug for erectile dysfunction improves heart function in young heart-disease patients

EurekAlert! - Medicine and Health — Wed, 18 Nov 2009 05:00:00 +0100

(Children's Hospital of Philadelphia) After treatment with sildenafil, heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation. Sildenafil is a drug commonly used to treat erectile dysfunction and pulmonary hypertension. (Source: EurekAlert! - Medicine and Health)

Mammographic Screening and Risk Factors for Breast Cancer

American Journal of Epidemiology — Wed, 18 Nov 2009 04:11:06 +0100

Screening mammography can distort estimated effects in breast cancer risk models due to associations with other risk factors. Mammography information was available in the Nurses’ Health Study from 1988, and 1,815 incident breast cancers were accrued through 2000 among 55,625 women with risk factor data. Logistic models were fit for screening mammography, and inverse probability weighting was used to adjust parameters in an established breast cancer risk model. Approximately 80% of women in each 2-year follow-up period had screening mammograms, which were positively associated with history of benign breast disease, family history of breast cancer, hormone therapy, alcohol use, physical activity, multivitamins, and calcium supplements, and negatively associated with postmenopause, curr...

Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study

Cardiovascular Diabetology — Wed, 18 Nov 2009 00:00:00 +0100

Background: Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic stroke is limited. In the present study, the association between serum resistin concentration and cardiovascular disease (CVD) was investigated in a general Japanese population. Methods: A total of 3,201 community-dwelling individuals aged 40 years or older (1,382 men and 1,819 women) were divided into quintiles of serum resistin, and the association between resistin and CVD was examined cross-sectionally. The combined effect of either diabetes or hypertension and high serum resistin was also assessed. Serum resistin was measured using ELISA. Results: Compared to those wi...

Does "Hidden Undercuffing" Occur Among Obese Patients? Effect of Arm Sizes and Other Predictors of the Difference Between Wrist and Upper Arm Blood Pressures

The Journal of Clinical Hypertension — Wed, 18 Nov 2009 00:00:00 +0100

J Clin Hypertens (Greenwich). Arm size can affect the accuracy of blood pressure (BP) measurement, and "undercuffing" of large upper arms is likely to be a growing problem. Therefore, the authors investigated the relationship between upper arm and wrist readings. Upper arm and wrist circumferences and BP were measured in 261 consecutive patients. Upper arm auscultation and wrist BP was measured in triplicate, rotating measurements every 30 seconds between sites. Upper arm BP was 131.9±20.6/71.6±12.6 mm Hg in an obese population (body mass index, 30.6±6.6 kg/m2) with mean upper arm size of 30.7±5.1 cm. Wrist BP was higher (2.6±9.2 mm Hg and 4.9±6.6 mm Hg, respectively, P (Source: The Journal of Clinical Hypertension)

The rationale and design of the antihypertensives and vascular, endothelial, and cognitive function (AVEC) trial in elderly hypertensives with early cognitive impairment: Role of the renin angiotensin system inhibition.

BMC Geriatrics — Wed, 18 Nov 2009 00:00:00 +0100

Background: Prior evidence suggests that the renin angiotensin system and antihypertensives that inhibit this system play a role in cognitive, central vascular, and endothelial function. Our objective is to conduct a double-blind randomized controlled clinical trial, the antihypertensives and vascular, endothelial, and cognitive function (AVEC), to compare 1 year treatment of 3 antihypertensives (lisinopril, candesartan, or hydrochlorothiazide) in their effect on memory and executive function, cerebral blood flow, and central endothelial function of seniors with hypertension and early objective evidence of executive or memory impairments. Methods: The overall experimental design of the AVEC trial is a 3-arm double blind randomized controlled clinical trial. A total of 100 community eligibl...

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Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population

BioMed Central — Wed, 18 Nov 2009 00:00:00 +0100

Background: Elastogenesis of elastic extracellular matrix (ECM) which was recognized as a major component of blood vessels has been believed for a long time to play only a passive role in the dynamic vascular changes of typical hypertension. Emilin1 gene participated in the transcription of ECM's formation and was recognized to modulate links TGF-beta maturation to blood pressure homeostasis in animal study. Recently relevant advances urge further researches to investigate the role of Emilin1 gene in regulating TGF-beta signals involved in elastogenesis and vascular cell defects of essential hypertension (EH). Methods: We designed a two-stage case-control study and selected three single nucleotide polymorphisms (SNPs), rs3754734, rs2011616 and rs2304682 from the HapMap database, which cove...

Restenosis after carotid endarterectomy: significance of newly acquired risk factors

European Journal of Neurology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion: CRFs acquired during long-term follow-up after CEA may independently contribute to progressive ICA stenosis after endarterectomy. Newly acquired CRFs might be more hazardous than CRFs present prior to CEA. (Source: European Journal of Neurology)

Transcendental Meditation Can Reduce Blood Pressure

Modern Medicine — Wed, 18 Nov 2009 00:00:00 +0100

Young adults who complete a program of training in transcendental meditation, and who are at risk of hypertension, are able to use the relaxation method to lower their blood pressure and levels of psychological distress, according to a study published online Oct. 1 and in the December issue of the American Journal of Hypertension. (Source: Modern Medicine)

Hypertension Found Common in Pediatric Kidney Disease

Modern Medicine — Wed, 18 Nov 2009 00:00:00 +0100

Children with chronic kidney disease often have high blood pressure, increasing their risk of left ventricular enlargement, according to a study published online Nov. 16 in the Journal of the American Society of Nephrology. (Source: Modern Medicine)

Air in the Portal and Mesenteric Veins

New England Journal of Medicine — Wed, 18 Nov 2009 00:00:00 +0100

A 73-year-old man with history of smoking, hypertension, chronic obstructive pulmonary disease, and type 2 diabetes mellitus presented with respiratory distress. The trachea was intubated, and the patient was admitted ... (Source: New England Journal of Medicine)

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Successful resolution of severe hepatopulmonary syndrome following liver transplantation

Transplant International — Wed, 18 Nov 2009 00:00:00 +0100

Hepatopulmonary syndrome (HPS) is a complication of portal hypertension, defined by the presence of liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations producing a right-to-left intrapulmonary shunt. Liver transplantation (LT) is the treatment of choice; however, severe hypoxemia (PaO2 < 50 mmHg on room air) is considered a contraindication to LT. This approach disadvantages some patients, particularly young patients with no intrinsic cardio-respiratory disease. We discuss one such patient who improved with LT despite having extremely severe HPS (PaO2 < 29 mmHg) (Source: Transplant International)

Epidemiology and comorbidity of psoriasis in children.

The British Journal of Dermatology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion: Psoriasis is a common disease in children. Like in adults, it is associated with significant comorbidity. Increased attention should be paid to the early detection and treatment of patients affected. PMID: 19922529 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

The effects of combination glaucoma medications on ocular surface epithelial cells.

Advances in Therapy — Wed, 18 Nov 2009 00:00:00 +0100

CONCLUSIONS: Both combination medications demonstrated a significant reduction in the percentage of live corneal and conjunctival epithelial cells compared with control. However, cell cultures exposed to timolol 0.5%+dorzolamide 2% had significantly fewer live cells compared with cell cultures exposed to timolol 0.5%+brimonidine 0.2%. Further studies are needed to better understand the clinical significance of these findings in patients using these medications for chronic treatment of glaucoma and ocular hypertension. PMID: 19921496 [PubMed - as supplied by publisher] (Source: Advances in Therapy)

Effects of landiolol, a short-acting beta-1 blocker, on hemodynamic variables during emergence from anesthesia and tracheal extubation in elderly patients with and without hypertension

Journal of Anesthesia — Tue, 17 Nov 2009 23:59:11 +0100

Conclusion This study indicates that the use of a landiolol infusion for preventing hemodynamic instability in elderly patients during the emergence period would be dependent on the presence or absence of hypertension in these patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-009-0805-9Authors Masumi Miyazaki, Tomioka General Hospital Department of Anesthesia Tomioka JapanYuji Kadoi, Gunma University Hospital Department of Anesthesiology 3-39-22 Showa-Machi Maebashi, Gunma 371-8511 JapanShigeru Saito, Gunma University Hospital Department of Anesthesiology 3-39-22 Showa-Machi Maebashi, Gunma 371-8511 Japan Journal Journal of AnesthesiaOnline ISSN 1438-8359Print ISSN 0913-8668 Journal Volume Volume 23 Journal Issue Volume 23...

Frasier syndrome, a potential cause of end-stage renal failure in childhood

Pediatric Nephrology — Tue, 17 Nov 2009 23:48:15 +0100

We describe the case of a 7-year-old girl who was referred to the paediatric emergency department with ESRF. Haemodialysis was started immediately because of severe hypertension and hyperkalaemia. In view of the fact that our patient had a past medical history of pseudohermaphroditism, we suspected that the acute presentation in ESRF may be related to a new diagnosis of Frasier syndrome. Our hypothesis was confirmed on examination of the medical records. There had been no medical follow-up for several years and, in particular, no renal imaging or functional assessment had ever been performed. This lack of surveillance explains why our patient presented with ESRF much earlier in this disease than expected and subsequently had to undergo kidney transplantation at a very young age. ...

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Early vascular phenotypes in the genesis of hypertension

Pediatric Nephrology — Tue, 17 Nov 2009 23:48:14 +0100

Abstract Cardiovascular complications occurring in adults find their roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure values in children represent an important measurable marker of the level of potential cardiovascular risk later in life because the levels are both the cause and the consequence of early vascular alterations. Early vascular phenotypes represent a field of great interest, and they can be studied through indirect assessment using non-invasive techniques. Estimations of blood pressure components, pulse wave velocity, and reflecting waves provide valuable information that can be easily recorded and repeated over time. A direct assessment, carried out by examining the umbilical vessels, can add furt...

The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study

Human Genetics — Tue, 17 Nov 2009 23:47:37 +0100

In conclusion, common variants in MYH9 polymorphisms may not confer an increased risk of CKD in American Indian populations. Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00439-009-0769-8Authors Nora Franceschini, University of North Carolina Department of Epidemiology 137 E. Franklin St., Suite 306 CB#8050 Chapel Hill NC 27514 USAV. Saroja Voruganti, Southwest Foundation for Biomedical Research Department of Genetics San Antonio TX USAKarin Haack, Southwest Foundation for Biomedical Research Department of Genetics San Antonio TX USALaura A...

Measurement uncertainty for the analysis of serum 25-hydroxyvitamin D: response to Stepman and Thienpont

Osteoporosis International — Tue, 17 Nov 2009 23:46:59 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00198-009-1098-4Authors E. Cavalier, University Hospital of Liège Department of Clinical Chemistry, University of Liège Domaine du Sart-Tilman 4000 Liège BelgiumP. Delanaye, University Hospital of Liège Department of Nephrology, Dialysis and Hypertension, University of Liège Liège BelgiumC. Cormier, Hôpital Cochin Department of Rheumatology Paris FranceJ. C. Souberbielle, Hôpital Necker-Enfants Malades Laboratoire d’Explorations Fonctionnelles Paris France Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)

Rosiglitazone does not improve endothelial function in patients with essential hypertension

Irish Journal of Medical Science — Tue, 17 Nov 2009 23:44:00 +0100

Conclusion Rosiglitazone improves insulin sensitivity in patients with essential hypertension. However, despite this there was no change in endothelial function. Content Type Journal ArticleCategory Oral PresentationsDOI 10.1007/BF03170270Authors S. T. B. Au, Royal Victoria Hospital Regional Centre of Endocrinology and Diabetes Belfast Northern IrelandC. Ennis, Royal Victoria Hospital Regional Endocrine Laboratory Belfast Northern IrelandA. B. Atkinson, Royal Victoria Hospital Regional Centre of Endocrinology and Diabetes Belfast Northern IrelandD. R. McCance, Royal Victoria Hospital Regional Centre of Endocrinology and Diabetes Belfast Northern IrelandB. Sheridan, Royal Victoria Hospital Regional Endocrine Laboratory Belfast Northern IrelandP. M. Bell, Royal Victoria Hosp...

Epidemiological usefulness of population-based electronic clinical records in primary care: estimation of the prevalence of chronic diseases

Family Practice — Tue, 17 Nov 2009 22:37:22 +0100

Conclusions. Prevalences estimated from ECRPC and survey data present variations depending on the disease, age and sex. Both data sources provide complementary information about chronic disease prevalence. ECRPC have the advantage of generating an ongoing standardized register and entailing no additional effort for health professionals. (Source: Family Practice)

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Which patient undergoing mitral valve surgery should also have the tricuspid repair? [Best evidence topic - Valves]

Interactive CardioVascular and Thoracic Surgery — Tue, 17 Nov 2009 18:56:36 +0100

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was ‘Which patient undergoing mitral valve surgery should also have the tricuspid repair?’ Altogether 390 papers were found using the reported search, of which 17 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. While a general agreement exists for tricuspid valve (TV) repair in cases of severe regurgitation and concomitant multivalvular disease requiring surgical intervention, current guidelines provide more vague indications for patients with less severe tricuspid regurgitation (TR). Since this condition...

Stroke in young Nigerian adults

Journal of Vascular Nursing — Tue, 17 Nov 2009 14:46:32 +0100

This study sought to determine the incidence, risk factors, stroke subtypes and case fatality of stroke among young Nigerian adults. The medical records of all 18- to 45-year-old patients admitted with stroke in the medical wards of the University of Port Harcourt Teaching Hospital (UPTH) from January 2003 to December 2008 were retrospectively reviewed. Of the 611 patients admitted with stroke, 54 (8.8%) were aged 18-45 years. There were 26 males and 28 females. Hypertension was responsible for 42 (77.8%) stroke cases. Other important risk factors were excessive alcohol intake (27.8%), heart disease (13%), diabetes mellitus (11.1%), cigarette smoking (11.1%) and HIV infection (7.4%). The total case fatality was 29.6% with intracerebral hemorrhage (ICH) having higher case fatality of 69.2% ...

Prehypertension increases risk for atherosclerosis in Type 2 diabetics

MedWire News - Hypertension — Tue, 17 Nov 2009 13:52:40 +0100

Prehypertension increases the risk for atherosclerosis in patients with Type 2 diabetes independently of other factors, show study results. (Source: MedWire News - Hypertension)

Global alliance of funders of public health research agrees top priorities

BMJ Online First — Tue, 17 Nov 2009 12:36:31 +0100

(Source: BMJ Online First)

Acute lower gastrointestinal haemorrhage

BMJ Online First — Tue, 17 Nov 2009 12:36:30 +0100

(Source: BMJ Online First)

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An Often Overlooked Protein Actually A Potent Regulator Of Cardiac Hypertrophy

Health News from Medical News Today — Tue, 17 Nov 2009 09:00:00 +0100

A protein long thought to be a secondary regulator in the heart's response to stressors like hypertension actually appears to be a primary regulator according to researchers from the Center for Translational Medicine at Thomas Jefferson University. The data will be presented in the Late Breaking Science session at the American Heart Associations Scientific Sessions in Orlando, Fla. (Source: Health News from Medical News Today)

An Often Overlooked Protein Actually A Potent Regulator Of Cardiac Hypertrophy

Cardiovascular / Cardiology News From Medical News Today — Tue, 17 Nov 2009 09:00:00 +0100

Moderate-Fat Diet May Be Better at Reducing Heart Risks

MedicineNet High Blood Pressure General — Tue, 17 Nov 2009 07:00:00 +0100

Title: Moderate-Fat Diet May Be Better at Reducing Heart RisksCategory: Health NewsCreated: 11/16/2009 4:10:00 PMLast Editorial Review: 11/17/2009 (Source: MedicineNet High Blood Pressure General)

U.S. Scores a 'D' on Preterm Birth Report Card

MedicineNet High Blood Pressure General — Tue, 17 Nov 2009 07:00:00 +0100

Title: U.S. Scores a 'D' on Preterm Birth Report CardCategory: Health NewsCreated: 11/17/2009 8:10:00 AMLast Editorial Review: 11/17/2009 (Source: MedicineNet High Blood Pressure General)

Highlights of NHLBI-supported research presented at American Heart Association's Scientific Sessions

EurekAlert! - Medicine and Health — Tue, 17 Nov 2009 05:00:00 +0100

(NIH/National Heart, Lung and Blood Institute) New education strategies for better controlling hypertension and research suggesting a possible link between short-term and long-term exposure to air pollution and increased risk of constricted blood vessels are among the research highlights from studies supported by the National Heart, Lung, and Blood Institute at the American Heart Association's 2009 Scientific Sessions in Orlando held Nov. 14-18. (Source: EurekAlert! - Medicine and Health)

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Norvir 100mg capsules (ritonavir) - Revised SPC

NeLM - SPC Changes — Tue, 17 Nov 2009 00:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Sections 4.3, 4.4, 4.5 of the SPC updated to include: Contra-indication for slidenafil when used for the treatment of pulmonary arterial hypertension (PAH) only. Increased plasma concentrations of sildenafil thereby, increasing the potential for sildenafil-associated adverse events (which include hypotension and syncope). See section 4.4 and section 4.5 for coadministration of sildenafil in patients with erectile dysfunction. Warning for concomitant use with salmetarol in Section 4.5. Ritonavir inhibits CYP3A4 and as a result a pronounced increase in the plasma concentrations of salmeterol is expected. Therefore concomitant use is not recommended. (Source: NeLM - SPC Changes)

Hospital stay can make dementia worse

OnMedica Latest News — Tue, 17 Nov 2009 00:00:00 +0100

Cutting hospital stays by a week could save £80m a year, claims charityRelated items from OnMedicaAll antipsychotic drugs linked to strokeWorking longer delays onset of dementiaHuge cost of dementia revealedRates of dementia worldwide have been underestimatedSmoking, hypertension and diabetes raise risk of dementia (Source: OnMedica Latest News)

Is chorionic villus sampling associated with hypertensive disorders of pregnancy?

Prenatal Diagnosis — Tue, 17 Nov 2009 00:00:00 +0100

Our objective is to evaluate for potential associations between chorionic villus sampling (CVS) and hypertensive disorders of pregnancy.Using our genetic database, we compared the rates of hypertensive disorders between women who underwent CVS at 10-13 and 6/7 weeks with those seen for other indications at similar gestational ages who had no invasive procedure. Only singleton and euploid pregnancies were included. Statistical methods including univariable and multivariable logistic regression, supplemented by stratified analyses were used for comparisons.Among 11 012 pregnant women seen between 1990 and 2006 in our center and meeting the inclusion criteria, information on hypertensive disorders of pregnancy were available in 9386, and 9098 met the inclusion criteria. The overall incidence ...

Self-management intervention can improve control in hypertension

NeLM - Cardiovascular Medicine — Tue, 17 Nov 2009 00:00:00 +0100

This study aimed to determine whether two self-management interventions, individually and together, could improve control. Patients were from two US primary care clinics and were randomised in a 2x2 design to either the behavioural intervention (regular telephone follow-up by a trained nurse), home BP monitoring three times a week, both, or usual care. Primary outcome was BP control at six-monthly intervals over two years. Of 636 patients randomised, 475 (75%) completed the two-year follow-up. In these patients, changes in control in the behavioural and home monitoring groups were positive but statistically not significant: proportions with improved control compared to usual care were 4.3% (95% CI, ?4.5% to 12.9%) and 7.6% (95% CI, ... (Source: NeLM - Cardiovascular Medicine)

Malignant Pheochromocytoma Presenting With Uncontrolled Hypertension After Kidney Transplant

The Journal of Clinical Hypertension — Tue, 17 Nov 2009 00:00:00 +0100

(Source: The Journal of Clinical Hypertension)

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Health Care Services Provided During Physician Office Visits for Hypertension: Differences by Specialty

The Journal of Clinical Hypertension — Tue, 17 Nov 2009 00:00:00 +0100

The objective of this study is to compare differences by physician specialty in the provision of health care services during office visits for hypertension. The authors examined office visits for US physicians by using data from the National Ambulatory Medical Care Survey for 2003 to 2005. Of more than 274 million hypertension visits, 35.5%, 43.9%, 8.5%, and 12.1% visits were made to general practitioners/family physicians, internists, cardiologists, and other specialties, respectively. Visitors to cardiologists were more likely to have coronary heart disease and heart failure than visitors to other physicians. While prescriptions for antihypertensive drugs overall were similar by specialty, cardiologists were more likely to prescribe lipid-lowering drugs (odds ratio [OR], 1.60; 95% confid...

Compliance With Home Blood Pressure Monitoring Among Middle-Aged Korean Americans With Hypertension

The Journal of Clinical Hypertension — Tue, 17 Nov 2009 00:00:00 +0100

J Clin Hypertens (Greenwich). The primary objective of this study was to investigate the factors affecting the level of compliance of home blood pressure monitoring (HBPM) and its relation to blood pressure (BP) control among hypertensive adults in a community setting. A total of 377 middle-aged Korean Americans with high BP participated in this study. Along with structured behavioral education, the participants were instructed to measure their BP 3 times in a row upon waking and thrice again at bedtime, at least 2 or more times a week for 48 weeks. Using multivariate logistic regression, the authors examined the patterns and factors affecting HBPM and its relation to BP control status. The analyses revealed that older participants were more compliant with the HBPM instruction than were yo...

Efficacy of an Olmesartan Medoxomil–Based Treatment Algorithm in Patients Stratified by Age, Race, or Sex

The Journal of Clinical Hypertension — Tue, 17 Nov 2009 00:00:00 +0100

J Clin Hypertens (Greenwich). Demographic factors are known to influence the prevalence of hypertension, and evidence suggests that they may also influence the response of patients with hypertension to blood pressure (BP)[ndash]lowering therapies. To determine the effect of demographic factors on the efficacy and safety of an olmesartan medoxomil (OM)[ndash]based treatment regimen, we performed a prespecified subgroup analysis of a 12-week, randomized, placebo-controlled, titrate-to-goal study in patients with hypertension, stratifying patients into treatment groups according to age, sex, or race. After 12 weeks, OM[ndash]based therapy significantly reduced BP from baseline in blacks, non-blacks, men, women, and patients younger than 65 or 65 years and older compared with placebo, and enab...

EMEA recommends orphan drug status for Elafin for cancer of the oesophagus

NeLM - News — Tue, 17 Nov 2009 00:00:00 +0100

Source: BioSpace Area: News According to a report by BioSpace.com, the Committee for Orphan Medical Products (COMP) of the European Medicines Agency (EMEA) has issued a recommendation granting orphan drug status for Elafin for the treatment of oesophagus carcinoma. The orphan drug status will become effective upon ratification of this recommendation by the European Commission, and is expected to occur in the last quarter of 2009. Elafin has already been granted orphan drug status for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension in 2007. (Source: NeLM - News)

Do worked examples foster medical students' diagnostic knowledge of hyperthyroidism?

Medical Education — Tue, 17 Nov 2009 00:00:00 +0100

Conclusions By providing erroneous examples in combination with elaborated feedback in a computer-based learning environment, diagnostic knowledge was fostered. The approach of 'learning from worked examples' was successfully adapted to a complex domain and was found to support the acquisition of complex competencies. (Source: Medical Education)

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Atrial Flutter Versus Atrial Fibrillation in a General Population: Differences in Comorbidities Associated With Their Respective Onset.

Clin Med Res — Tue, 17 Nov 2009 00:00:00 +0100

Conclusion This study represents the first report to evaluate potential differences in the conditions associated with the development of AFL versus AF. Research into the mechanisms of atrial arrhythmogenesis may lead to improved preventive and therapeutic interventions. PMID: 19920163 [PubMed - as supplied by publisher] (Source: Clin Med Res)

Two Self-management Interventions to Improve Hypertension Control: A Randomized Trial.

Annals of Internal Medicine — Tue, 17 Nov 2009 00:00:00 +0100

Conclusion: Combined home BP monitoring and tailored behavioral telephone intervention improved BP control, systolic BP, and diastolic BP at 24 months relative to usual care. Primary Funding Source: National Heart, Lung, and Blood Institute; Pfizer Foundation Health Communication Initiative; and the American Heart Association. PMID: 19920269 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Tight BP control reduced left ventricular hypertrophy in nondiabetic patients with hypertension.

Annals of Internal Medicine — Tue, 17 Nov 2009 00:00:00 +0100

Authors: PMID: 19920265 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Review: Low BP targets do not reduce mortality or CV events in hypertension.

Annals of Internal Medicine — Tue, 17 Nov 2009 00:00:00 +0100

Authors: PMID: 19920264 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Factors Associated with Multiple Medication Use in Different Age Groups(December).

The Annals of Pharmacotherapy — Tue, 17 Nov 2009 00:00:00 +0100

CONCLUSIONS: Multiple medicine use was associated with morbidity and poor self-rated health across all age groups. The vast majority of users of multiple drugs are taking a unique combination of medications. PMID: 19920158 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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Viagra: The profitable pill

Guardian Unlimited Science — Mon, 16 Nov 2009 22:43:08 +0100

When Pfizer launched Viagra in 1998 its share price doubled within days. Since then, the little blue pills have become a pillar of profit, earning the company more than £1bn a year.Thanks to promotional campaigns, which included appearances by the footballing legend Pele, male impotence lost some of its stigma and 25 million men requested the pills. In England alone, GPs write about 6m Viagra prescriptions a year.The drug started life in a lab in Sandwich, Kent, where it was developed to treat high blood pressure. Its transformation into a blockbuster treatment for impotence began when volunteers in a clinical trial reported a suspicious number of erections. The overnight success of Viagra prompted Pfizer to wonder if the drug had any effect in women. They raised awareness of a condition ...

Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke

Neurology — Mon, 16 Nov 2009 21:02:02 +0100

Conclusion: Impaired kidney function is associated with the presence of cerebral microbleeds in acute ischemic stroke. (Source: Neurology)

Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis

Cardiovascular Research — Mon, 16 Nov 2009 20:06:16 +0100

Conclusion These data suggest that the maintenance of adrenergic vascular tone by the MMP–EGFR pathway requires PI3K activation and ATP synthesis. Further, our data support the view that elevated levels of GPCR agonists exaggerate the MMP transactivation of EGFR response and contribute to enhanced vascular tone and development of cardiovascular disease such as hypertension. (Source: Cardiovascular Research)

A case of stroke induced micrographia

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

REVEAL: Familial PAH Linked to More Severe Hemodynamic Abnormalities Than Idiopathic PAH

Medscape Medical News Headlines — Mon, 16 Nov 2009 17:28:23 +0100

Severe hemodynamic abnormalities are found at first diagnosis in patients with familial pulmonary arterial hypertension (PAH). Medscape Medical News (Source: Medscape Medical News Headlines)

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Transport of the Neonatal Patient With Persistent Pulmonary Hypertension

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

This article will review the pathophysiology, assessment, diagnosis, and treatment options for a newborn with persistent pulmonary hypertension of the newborn, and considerations for infant transport to a higher level of care will be emphasized. (Source: Newborn and Infant Nursing Reviews)

Extraspinal manifestations of diffuse idiopathic skeletal hyperostosis

Rheumatology — Mon, 16 Nov 2009 16:00:32 +0100

DISH is a condition characterized by calcification and/or ossification of soft tissues, mainly entheses, ligaments and joint capsules. Its prevalence increases with age and, therefore, DISH is a relatively common entity in the elderly. The classical site of involvement is the spinal column with right anterolateral soft tissue ossification being the most characteristic feature. However, DISH is not limited to the spine, and may affect multiple peripheral sites independently. Extraspinal entheseal ossifications are common and observing their isolated presence may lead to the diagnosis of DISH. Furthermore, hypertrophic or atypical OA observed in joints usually not affected by primary OA has frequently been reported in DISH. Several metabolic derangements and concomitant diseases have been su...

Prevalence and risk factors for pulmonary arterial hypertension in patients with lupus

Rheumatology — Mon, 16 Nov 2009 16:00:32 +0100

Conclusions. The point prevalence of PAH was 4.2% in our cohort of patients with SLE. Most of the PAH cases were found to be of mild severity (<40 mmHg). The significant association of LAC and presence of APS in PAH cases suggests that thrombosis may play an important role in PAH with SLE. This is important, as it is treatable. (Source: Rheumatology)

Nervous system dysfunction in Henoch-Schonlein syndrome: systematic review of the literature

Rheumatology — Mon, 16 Nov 2009 16:00:32 +0100

Conclusions. In Henoch–Schönlein syndrome, signs of nervous system dysfunction are uncommon but clinically relevant. This review helps clinicians managing Henoch–Schönlein syndrome with nervous system dysfunction. (Source: Rheumatology)