MedWorm: Migraine

Neurologic adverse events following influenza A (H1N1) vaccinations in children

Pediatrics International — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: Post‐vaccine NAEs were mainly motor weakness due to poly‐neuropathy, which had a good prognosis of complete improvement within a few months without sequelae.© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society (Source: Pediatrics International)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Cardiac and vascular responses to thigh cuffs and respiratory maneuvers on crewmembers of the International Space Station

Journal of Applied Physiology — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: acute application of Braslet occlusion cuffs causes lower extremity fluid sequestration and exerts commensurate measurable effects on cardiac performance in microgravity. Ultrasound techniques to measure the hemodynamic effects of thigh cuffs in combination with respiratory maneuvers may serve as an effective tool in determining the volume status of a cardiac or hemodynamically compromised patient at the "microgravity bedside." (Source: Journal of Applied Physiology)

Pain (Acute and Chronic)

MedicineNet Migraine General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Pain (Acute and Chronic)Category: Doctor's ViewsCreated: 11/30/2004Last Editorial Review: 2/1/2012 (Source: MedicineNet Migraine General)

First Drug to Target Cause of Cystic Fibrosis Approved

MedicineNet Migraine General — Wed, 01 Feb 2012 07:00:00 +0100

Title: First Drug to Target Cause of Cystic Fibrosis ApprovedCategory: Health NewsCreated: 2/1/2012 11:01:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Migraine General)

EXTRA STRENGTH HEADACHE RELIEF (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [CHAIN DRUG MARKETING ASSOCIATION INC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cytokine Dermatitis and Febrile Seizure From Imiquimod

PEDIATRICS — Wed, 01 Feb 2012 05:00:00 +0100

We describe herein a case of severe cytokine dermatitis in a 2-year-old female patient treated with daily imiquimod for molluscum contagiosum who subsequently developed febrile seizure. We believe this to be the first reported case of seizure associated with imiquimod 5% cream (Aldara, 3M) in a pediatric setting. (Source: PEDIATRICS)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Rheumatoid Arthritis - When Do I Call the Doctor?

MedicineNet Migraine General — Tue, 31 Jan 2012 07:00:00 +0100

Title: Rheumatoid Arthritis - When Do I Call the Doctor?Category: Doctor's ViewsCreated: 7/7/2001 12:46:00 PMLast Editorial Review: 1/31/2012 (Source: MedicineNet Migraine General)

'I Wanted To Live:' New Depression Drugs Offer Hope For Toughest Cases

NPR Health and Science — Tue, 31 Jan 2012 05:01:00 +0100

The anesthetic and club drug ketamine seems to lift depression symptoms in a matter of hours. But how does it work? Researchers are searching for the answer in an attempt to make a new class of depression medications. "We can take care of a migraine in hours," one researcher asks. "So why do we have to wait weeks or months with depression?"» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)

'I Wanted To Live': New Depression Drugs Offer Hope For Toughest Cases

NPR Health and Science — Tue, 31 Jan 2012 05:01:00 +0100

Intracranial hypotension headache after uncomplicated caudal epidural injection

Anaesthesia — Tue, 31 Jan 2012 05:00:00 +0100

We describe the aetiology, presentation and treatment of spontaneous intracranial hypotension and review the similarities with our patient’s clinical presentation. We hypothesise as to how our intervention may have resulted in a dural tear. (Source: Anaesthesia)

Predictive index for the onset of medication overuse headache in migraine patients

Neurological Sciences — Mon, 30 Jan 2012 16:04:43 +0100

Abstract Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as signific...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Small‐vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: Two subsets of giant cell arteritis

Arthritis and Rheumatism — Mon, 30 Jan 2012 13:25:25 +0100

ConclusionOur findings indicate that isolated VVV and SVV should be considered part of the histopathologic spectrum of GCA. (Source: Arthritis and Rheumatism)

Weekly Shot Gets FDA Nod for Type 2 Diabetes

MedicineNet Migraine General — Mon, 30 Jan 2012 07:00:00 +0100

Title: Weekly Shot Gets FDA Nod for Type 2 DiabetesCategory: Health NewsCreated: 1/28/2012 11:00:00 AMLast Editorial Review: 1/30/2012 (Source: MedicineNet Migraine General)

Ossifying Pituitary Adenoma Co-existing with Astrocytoma and Pituitary Adenoma Associated with Gangliocytoma: Two Unusual Conditions.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

Authors: Jaiswal S, Vij M, Jaiswal AK, Chand G, Behari S, Kumarjain V Abstract Bone formation in pituitary adenoma is an extremely rare finding. Only five previous cases have been published. This is the sixth case report of an ossifying pituitary adenoma and the first case report of a pituitary adenoma with bone formation coexisting with WHO grade II astrocytoma. MRI imaging revealed an unusual eggshell cap-like calcified structure surrounding the tumor. Histologically, the adenoma contained irregularly anastomosing trabeculae with well-formed lacunae and osteoblasts along the margins. Our second case concerns a 25-year-old male patient who presented with complains of off and on headache for 12 months. MRI (head) revealed a 4x3cm well defined rounded lesion in the ...

Endoscopic management of a lower clival chondroid chordoma: case report.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

We report herein a case of lower clival chondroid chordoma, focusing on the surgical procedure of endoscopic endonasal surgery. A 36-yearold woman presented with progressive headache, right shoulder pain, and right hypoglossal nerve palsy. Computed tomography (CT) and magnetic resonance (MR) imaging revealed an extradural tumor located in the lower clivus, including the anterior aspect of the foramen magnum, deeply compressing the medulla and upper cervical spinal cord. Endoscopic endonasal surgery was performed via two nostrils. Since the basiocciput was destroyed by the tumor, removal of the tumor allowed identification of the middle clivus superiorly, the anterior arch of the atlas inferiorly, and anteromedial parts of occipital condyles bilaterally without drilling ...

Chronic subdural hematoma after endoscopic third ventriculostomy: a case report and literature review.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

Authors: Tekin T, Colak A, Kutlay M, Demircan MN Abstract Chronic subdural hematoma is a very rarely observed complication after endoscopic third ventriculostomy (ETV). A 21-year-old male patient was admitted to our clinic with complaining of headache, weakness and tremor. The fundoscopic examination revealed slightly indistinct border of the papilla and neurological examination findings were normal. The cranial computed tomographic (CT) and magnetic resonance imaging (MRI) findings demonstrated three-ventricular hydrocephalus due to aqueductal stenosis and ETV was performed. The symptoms got better after the operation. At 1½ month postoperatively the patient reapplied to our clinic with a symptom of severe headache. Cranial BT imaging demonstrated enlargement of...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

A case of primary diffuse leptomeningeal gliomatosis predominantly involving the cervical spinal cord and mimicking chronic meningitis.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

Authors: Heijink DS, Urgun K, Sav A, Seker A, Konya D Abstract Gliomas may rarely arise in the leptomeninges without any evidence of intraaxial involvement. A case of primary diffuse leptomeningeal gliomatosis (PDLG) histologically diagnosed as oligoastrocytoma is presented. A 50-year-old woman presented with nausea, vomiting and headache. Magnetic resonance imaging (MRI) of cranium and cervical region revealed dural thickening starting from the craniocervical junction to the level of C4 without any parenchymal lesions. CSF examination showed an increase in protein and decrease in glucose levels. There were neither any kind of atypical cells nor any kind of growth in bacterial cultures. The patient underwent biopsy at the level of C1 for diagnosis. The specimen wa...

Extradural haematoma in children: surgical experiences and prospective analysis of 170 cases.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

CONCLUSION: EDH is recognized as one of the most rewarding neurosurgical emergencies. It must be diagnosed in the early period of the trauma and evacuated early to prevent potential mortality and morbidity. Different factors affect the outcome of extradural haematoma Surgery including age of the patient, presence of cranial fractures, associated brain lesions and pre-operative neurological condition of patient, duration of time interval between onset of coma and surgical intervention. Better prognosis is seen in patients less than 10 years of age. PMID: 22274969 [PubMed - in process] (Source: Turkish Neurosurgery)

Lumbar peritoneal shunt in idiopathic intracranial hypertension.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

CONCLUSION: LP shunt is safe and effective in IIH. Results in terms of improvement in vision were better in good pre operatively vision group. PMID: 22274966 [PubMed - in process] (Source: Turkish Neurosurgery)

No effect of recumbency duration on the occurrence of post-lumbar puncture headache with a 22G cutting needle

BMC Neurology — Mon, 30 Jan 2012 05:00:00 +0100

Conclusions: Our study suggests that short duration (one hour) of supine recumbence may be as efficient as long duration (four hours) of supine recumbence to prevent PLPH. (Source: BMC Neurology)

Pediatric Headache: A Clinical Review

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

In this review we describe the epidemiology, classification, and approach to the diagnosis and treatment of episodic and chronic migraine in children. We review both traditional and alternative medications, and offer a glimpse into the future of pediatric headache. (Source: Headache: The Journal of Head and Face Pain)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Expert Commentary on Pediatric Headache

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

(Source: Headache: The Journal of Head and Face Pain)

Pharmacokinetics and Tolerability of Rizatriptan in Pediatric Migraineurs in a Randomized Study

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

Conclusions.— In pediatric migraineurs, a weight‐based dosing scheme generated plasma rizatriptan AUC(0‐∞) and Cmax values that were generally similar to those historically observed in adults administered a 10‐mg dose of rizatriptan ODT (a proven effective dose). The data support further evaluation of the safety, tolerability, and efficacy of this rizatriptan dosing scheme in larger scale clinical trials in the pediatric migraineur population. (Source: Headache: The Journal of Head and Face Pain)

Pediatric Headache: Update on Recent Research

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

Primary headache are one of the most common health complaints in children and adolescents, yet there remain significant gaps in our understanding of the underlying pathophysiology of these conditions. Recently, there have been several areas of research that have assisted with filling this gap in our knowledge. These areas include a better understanding of the disease characteristics including additional associated symptoms and the refinement of the description of related conditions and comorbidities; continued examination of the epidemiology of primary headaches; the progression of migraine across these developmental ages; the molecular and physiological changes; and the potential role for vitamins and cofactor deficiencies in the pathophysiology. These studies continue to add to our fund ...

Concomitant Use of Triptan, and SSRI or SNRI After the US Food and Drug Administration Alert on Serotonin Syndrome

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

Conclusion.— Our study documents that 1.8% (1,319,763/73,860,558) of patients in 2007‐2008 were prescribed triptan, and SSRI or SNRI (vs 1.3% in 2003‐04, an increase of 38.5%). While this is a small fraction overall, the actual number of patients on a nationwide basis is substantial. What remains missing from the literature is documentation as to the number of cases of serotonin syndrome and resulting consequences (clinical and economic) because of the concomitant use of triptan, and SSRI or SNRI in the time‐frame 2007‐2008. Absent in these data, it remains difficult to assess the risk benefit associated with the use of triptan, and SSRI or SNRI. (Source: Headache: The Journal of Head and Face Pain)

Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons

Headache: The Journal of Head and Face Pain — Mon, 30 Jan 2012 05:00:00 +0100

Conclusion.— Our results build on previous work indicating that TRPV1 channels in trigeminal nociceptors play a role in craniofacial pain. Our findings that TRPV1 is inhibited by the specific antimigraine drug sumatriptan, and that TRPV1 channels are functional in neurons projecting to cerebral dura suggests a specific role for these channels in migraine or cluster headache. (Source: Headache: The Journal of Head and Face Pain)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Comment: Mobile technology in neurology

Neurology — Mon, 30 Jan 2012 05:00:00 +0100

(Source: Neurology)

Clinical Reasoning: A 33-year-old woman with severe postpartum occipital headaches

Neurology — Mon, 30 Jan 2012 05:00:00 +0100

(Source: Neurology)

Headache Emergencies: Diagnosis and Management

Neurologic Clinics — Mon, 30 Jan 2012 02:28:35 +0100

Headaches are a common reason for visiting a health care provider. Headaches are at times symptomatic of an underlying process that requires prompt diagnosis and urgent treatment to reduce threats to life or limb. In this article, the authors review the 6 most common presentations for worrisome headache and discuss the differential diagnosis. Careful attention to patients’ history and physical examination and a thoughtful approach to the differential diagnosis will guide diagnostic work-up and management. Although benign causes of headache are much more common than malignant secondary processes, thorough management of the acute headache requires excluding malignant secondary processes. (Source: Neurologic Clinics)

Botox for Treating Migraines

Sound Medicine — Sun, 29 Jan 2012 05:00:00 +0100

So much attention has been focused on the cosmetic uses of botulinum toxin, usually known by its trade name, Botox, that it's easy to forget about the drug's serious medical uses. For example, the FDA recently approved Botox for preventing chronic migraines. Sound Medicine's David Crabb, MD, sat down with Indiana University neurologist Jay Bhatt, MD, to learn how it works. Dr. Bhatt is.... (Source: Sound Medicine)

Inhaled Oxygen for Cluster Headache: Efficacy, Mechanism of Action, Utilization, and Economics

Current Pain and Headache Reports — Sat, 28 Jan 2012 16:52:05 +0100

This article examines various issues regarding inhaled oxygen and cluster headache, including efficacy, proposed mechanism of action, utilization, and the economics of oxygen usage for cluster headache patients. Much of the data analyzed comes from the recently published United States Cluster Headache Survey. This is the largest study of cluster headache patients ever published and is the first study to focus on inhaled oxygen and cluster headache in a large, non-clinic-based population. Content Type Journal ArticleCategory Trigeminal Autonomic Cephalalgias (M Matharu, Section Editor)Pages 1-5DOI 10.1007/s11916-012-0246-2Authors Todd D. Rozen, Geisinger Specialty Clinic, MC 37-31, 1000 East Mountain Drive, Wilkes-Barre, PA 18711, USA Journal Current Pain and Headache Repor...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells

Investigational New Drugs — Fri, 27 Jan 2012 17:54:52 +0100

In conclusion the neurotransmitter serotonin could be successfully used to target imaging agents into human glioblastoma cells. This makes it of interest for future glioblastoma imaging methods. Content Type Journal ArticleCategory PRECLINICAL STUDIESPages 1-7DOI 10.1007/s10637-011-9781-7Authors Alexander Sturzu, Department of Neuroradiology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, GermanySumbla Sheikh, Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, GermanyUwe Klose, Department of Neuroradiology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, GermanyHartmut Echner, Peptide Synthesis Laboratory, Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, GermanyHubert Ka...

Case of the Month #175: Intracranial Blastomycosis

Canadian Association of Radiologists Journal — Fri, 27 Jan 2012 08:38:27 +0100

A 27-year-old man from Ontario was referred to the neurology service for a 2-month history of left-sided headache, slurred speech, and limp. Results of a neurologic examination revealed increased tone on the right, as well as right-sided weakness and clonus of the right ankle reflex. Contrast-enhanced computed tomography (CT) of the head () was performed after a noncontrast study revealed mass lesions in the left cerebral hemisphere and left posterior fossa. A recent chest radiograph () was also available at the time of the CT study. (Source: Canadian Association of Radiologists Journal)

Risk of neurological diseases among survivors of electric shocks: A nationwide cohort study, Denmark, 1968–2008

Bioelectromagnetics — Fri, 27 Jan 2012 08:35:32 +0100

AbstractSeveral studies suggest a link between electric injuries and neurological diseases, where electric shocks may explain elevated risks for neuronal degeneration and, subsequently, neurological diseases. We conducted a retrospective cohort study on the risk of neurological diseases among people in Denmark who had survived an electric accident in 1968–2008. The cohort included 3,133 people and occurrences of neurological diseases were determined by linkage to the nationwide population‐based Danish National Register of Patients. The numbers of cases observed at first hospital contact in the cohort were compared with the respective rates of first hospital contacts for neurological diseases in the general population. We observed significantly increased risks for peripheral nerve disea...

Acupuncture May Boost Pregnancy Success Rates

MedicineNet Migraine General — Fri, 27 Jan 2012 07:00:00 +0100

Title: Acupuncture May Boost Pregnancy Success RatesCategory: Health NewsCreated: 1/27/2012 10:05:00 AMLast Editorial Review: 1/27/2012 (Source: MedicineNet Migraine General)

Pharmacokinetics and central nervous system effects of the novel dopamine D3 receptor antagonist GSK598809 and intravenous alcohol infusion at pseudo-steady state

Journal of Psychopharmacology — Fri, 27 Jan 2012 05:00:00 +0100

In conclusion, GSK598809 causes elevation of serum prolactin and a small decrease in adaptive tracking performance. After co-administration with alcohol, effects of GSK598809 are mainly additive and the combination is well tolerated in healthy volunteers. (Source: Journal of Psychopharmacology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

M.E. Thompson, Inc. Recalls Anytime Deli Brand Turkey & Ham Footlong Sandwich Because Of Possible Health Risk

Food and Drug Administration — Thu, 26 Jan 2012 15:10:00 +0100

M.E. Thompson, Inc. of Jacksonville, FL is recalling its Anytime Deli Turkey & Ham Sub Sandwich, UPC 0543200194, with an expiration date of January 19th and January 22nd because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, listeria infection can cause miscarriages and stillbirths among pregnant women. (Source: Food and Drug Administration)

Purpura Fulminans Secondary to Streptococcus pneumoniae Meningitis

Clinical and Developmental Immunology — Thu, 26 Jan 2012 11:22:23 +0100

Purpura fulminans (PF) is a rare skin disorder with extensive areas of blueblack hemorrhagic necrosis. Patients manifest typical laboratory signs of disseminated intravascular coagulation (DIC). Our case describes a 37-year-old previously healthy man who presented with 3 days of generalized malaise, headache, vomiting, photophobia, and an ecchymotic skin rash. Initial laboratory workup revealed DIC without obvious infectious trigger including unremarkable cerebrospinal fluid (CSF) biochemical analysis. There was further progression of the skin ecchymosis and multiorgan damage consistent with PF. Final CSF cultures revealed Streptococcus pneumoniae. Despite normal initial CSF biochemical analysis, bacterial meningitis should always be considered in patients with otherwise unexplained DIC as...

New Clinical Trial Guidelines For Migraine

Health News from Medical News Today — Thu, 26 Jan 2012 08:00:00 +0100

Experts from the International Headache Society (IHS) have developed new recommendations for conduct of acute and preventive migraine clinical trials. The third edition of Migraine Clinical Trials Guidelines is now available in the IHS journal Cephalalgia, which is published by SAGE. The new guidelines represent an expert consensus summary, and recommend a contemporary, standardized, and evidence-based approach to investigators conducting and reporting randomised, controlled migraine clinical trials... (Source: Health News from Medical News Today)

An open‐label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

CONCLUSIONS:Although RPI.4610 demonstrated a well‐tolerated safety profile, its lack of clinical efficacy precludes this drug from further development. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer)

Average Briton suffers 152 migraines, 133 colds and has 210 backaches (but you should live longer than your parents)

the Mail online | Health — Thu, 26 Jan 2012 00:10:29 +0100

The report, which was published by Health-on-Line.co.uk, traces the illnesses and injuries endured by British men and women. (Source: the Mail online | Health)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Metabolic syndrome and insulin resistance in migraine

The Journal of Headache and Pain — Wed, 25 Jan 2012 18:07:54 +0100

This study was therefore undertaken to compare the clinical characteristics of migraine in patients with and without metabolic syndrome and insulin resistance. 135 consecutive patients with migraine diagnosed on the basis of International Headache Society criteria were subjected to clinical evaluation as per fixed protocol. Headache severity, frequency and functional disability were recorded. Metabolic syndrome was diagnosed as per National Cholesterol Education Programme: Adult Treatment Panel III and International Diabetic Federation criteria. Insulin resistance was calculated by homeostases model assessment. Their age ranged between 14 and 61 years and 108 were females. Metabolic syndrome was present in 31.9% patients and only 13 were obese. Insulin resistance was present in ...

Topical beta-blocker treatment for migraine

International Ophthalmology — Wed, 25 Jan 2012 18:07:46 +0100

Abstract Beta-blockers are a well-known prophylactic treatment for migraine; however, treatment by the ocular route has not been widely considered. This case illustrates the resolution of a visual field defect associated with migraine and improvement of symptoms possibly due to administration of a topical beta-blocker. This novel method of treatment especially when visual field defects are present may have a place in the management of migraine. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10792-012-9516-6Authors Patrick J. T. Chiam, Eye Unit, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire HP21 8AL, UK Journal International OphthalmologyOnline ISSN 1573-2630Print ISSN 0165-5701 (Source: International Ophthalmology)

Syndrome of inappropriate antidiuretic hormone associated with moxifloxacin.

American Journal of Health-System Pharmacy : AJHP — Wed, 25 Jan 2012 14:49:21 +0100

Conclusion A 66-year-old woman developed severe hyponatremia after receiving moxifloxacin for five days for treatment of COPD exacerbation. PMID: 22261943 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Could 'Magic' Mushrooms Ease Depression?

MedicineNet Migraine General — Wed, 25 Jan 2012 07:00:00 +0100

Title: Could 'Magic' Mushrooms Ease Depression?Category: Health NewsCreated: 1/24/2012 2:05:00 PMLast Editorial Review: 1/25/2012 (Source: MedicineNet Migraine General)

Giant Intracranial Pial Arteriovenous Fistula Treated by Endovascular Intervention

min - Minimally Invasive Neurosurgery — Wed, 25 Jan 2012 05:00:00 +0100

Minim Invasive Neurosurg 2011; 54: 247-249DOI: 10.1055/s-0031-1283127Arteriovenous fistulas (AVF) are rare vascular lesions of the brain that differ from arteriovenous malformations as they present a direct connection between artery and vein, without interposition of the nidus. They are fed by one or more arterial branches, with a single draining vein. Clinically they can be revealed through cerebral hemorrhage, convulsive crisis, neurological deficit, heart failure in neonates and infants, headache, bruit, or intracranial hypertension symptoms.A 30-year-old patient was found unconscious on a public street, presenting a generalized tonic-clonic convulsive crisis. At admission, she presented with ocular proptosis, conjunctival hyperemia and bilateral jugular turgescence. The cranial compute...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Clinical Pharmacology of Current and Future Drugs for the Acute Treatment of Migraine: A Review and an Update.

Current Clinical Pharmacology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Tfelt-Hansen P Abstract Migraine is a common disorder with a female prevalence of 17% and a male prevalence of 9%. Migraine is most often disabling and the patients need treatment of the attacks. The introduction of triptans has been a revolution for many migraine patients but only a minority of patients use these specific drugs. The pharmacokinetics and efficacy and tolerability of triptans are reviewed. The triptans can most likely with advantage be combined with NSAIDs and prokinetic drugs. Among future drugs, CGRP receptor antagonists are the most promising. These drugs have shown excellent tolerability with no more adverse events than placebo, but only one quarter of migraine patients have been pain-free after 2 hours in phase III studies. The development of current C...

Peripartum Subarachnoid Hemorrhage: Nationwide Data and Institutional Experience

Anesthesiology — Tue, 24 Jan 2012 22:05:24 +0100

Conclusion: SAH during pregnancy results from a range of etiologies, and is less likely to be because of a cerebral aneurysm than SAH occurring in the nonpregnant patient. Peripartum SAH frequently occurs in the setting of hypertensive disorders. (Source: Anesthesiology)

Active Agent in 'Magic Mushrooms' May Be TherapeuticActive Agent in 'Magic Mushrooms' May Be Therapeutic

Medscape Today Headlines — Tue, 24 Jan 2012 18:48:42 +0100

A new imaging study supports evidence that psilocybin, the active ingredient in 'magic mushrooms,' may have therapeutic effects for conditions such as depression, anxiety, and cluster headache. Medscape Medical News (Source: Medscape Today Headlines)

Frontal Sinus Osteoma with Osteoblastoma-like Histology and Associated Intracranial Pneumatocele

Head and Neck Pathology — Tue, 24 Jan 2012 18:14:59 +0100

Abstract Osteomas of the cranial sinuses are rare, benign bony tumors that can be complicated by the formation of an intracranial pneumatocele. If not treated promptly, a pneumatocele can lead to abscess formation, meningitis, or ventriculitis. In the present case, an intracerebral pneumatocele was formed when an 18 cm3 osteoma breached the posterior wall of the frontal sinus creating a one-way valve through which air could enter the intracranial cavity. The patient presented after forceful sneezing with nonspecific symptoms of headache, nausea, and vomiting. CT demonstrated a frontal collection of loculated air with mass effect within the left cerebral hemisphere. A partly mineralized mass occupied the left superior nasal ethmoid sinus and left frontal sinus. Of inter...

Hematoma of Meckel’s cave: a rare possible symptomatic trigeminal neuralgia

Journal of Neurology — Tue, 24 Jan 2012 18:09:46 +0100

Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00415-012-6410-0Authors F. Maggioni, Department of Neurosciences, Headache Centre, University of Padua, Via Giustiniani 5, 35128 Padua, ItalyM. Bellamio, Department of Neurosciences, Headache Centre, University of Padua, Via Giustiniani 5, 35128 Padua, ItalyM. Margoni, Department of Neurosciences, Headache Centre, University of Padua, Via Giustiniani 5, 35128 Padua, ItalyG. Zanchin, Department of Neurosciences, Headache Centre, University of Padua, Via Giustiniani 5, 35128 Padua, ItalyR. Manara, Neuroradiology Unit, University of Padua, Padua, Italy Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Traumatic Head Injury in Cluster Headache: Cause or Effect?

Current Pain and Headache Reports — Tue, 24 Jan 2012 12:27:19 +0100

Abstract Post-traumatic headache (PTH) is a common and well-recognized entity. Tension-type headache and migraine are the commonest phenotypes that can result from head trauma, while the onset of cluster headache (CH) in close temporal relation to a head trauma has only been described in rare cases. Nevertheless, CH patients seem to incur more frequent traumatic head injuries during their lifetimes when compared to migraine controls and the general population. The basis of this association remains unclear, since only a limited number of methodologically robust studies have examined it. However, three main hypotheses can be proposed to explain this association: head trauma is the direct cause of CH; head trauma is a risk factor for the future development of CH; and head tra...

The Patient-Provider Relationship in Chronic Pain

Current Pain and Headache Reports — Tue, 24 Jan 2012 12:27:19 +0100

Abstract The relationship between patient and provider has long been the subject of study within the psychotherapy literature, with the available data suggesting a modest, but reliable, association between the strength of this relationship and treatment outcome. Conversely, there has been little work focused on the patient–provider relationship in chronic pain settings despite the complexities and difficulties that are often involved in this area. This review provides a brief, broad overview of the literature on the patient–provider relationship and identifies key aspects that are specifically relevant to chronic pain settings. In addition to reviewing the literature in this area, a series of recommendations for future clinical and academic work are offered. Conte...

OnabotulinumtoxinA in Pediatric Chronic Daily Headache

Current Neurology and Neuroscience Reports — Tue, 24 Jan 2012 12:27:04 +0100

This study showed a major change in the frequency of the headache with a statistical difference in the improvement of headache days per month. There was a 30-point drop in the pediatric disability scoring between first injection and follow-up injection with a change from severe disability to moderate disability. Content Type Journal ArticleCategory Headache (I Garza, Section Editor)Pages 1-4DOI 10.1007/s11910-012-0251-1Authors Marielle Kabbouche, Division of Neurology, Cincinnati Children’s Hospital Medical Center, Headache Center, MLC #2015, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USAHope O’Brien, Division of Neurology, Cincinnati Children’s Hospital Medical Center, Headache Center, MLC #2015, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USAAndrew D. Hershey, Divis...

Therapeutic evaluation of different needling methods for tension-type headache

Journal of Acupuncture and Tuina Science — Tue, 24 Jan 2012 07:58:39 +0100

摘要目的观察比较疏肝调神针刺法和常规针刺法对紧张型头痛患者焦虑和抑郁症状的疗效。方法 120 例紧张型头痛伴有焦虑和/或抑郁症状的患者按随机数字表随机分为疏肝调神针刺组(A组)和常规针刺组(B组), 每组60 例。采用焦ŗ...

Targeting the brain: considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases

Neurological Sciences — Tue, 24 Jan 2012 07:34:35 +0100

Abstract Deep brain stimulation (DBS) extends the treatment of some severe neurological diseases beyond pharmacological and conservative therapy. Our experience extends the field of DBS beyond the treatment of Parkinson disease and dystonia, including several other diseases such as cluster headache and disruptive behavior. Since 1993, at the Istituto Nazionale Neurologico “Carlo Besta” in Milan, 580 deep brain electrodes were implanted in 332 patients. The DBS targets include Stn, GPi, Voa, Vop, Vim, CM–pf, pHyp, cZi, Nacc, IC, PPN, and Brodmann areas 24 and 25. Three hundred patients are still available for follow-up and therapeutic considerations. DBS gave a new therapeutic chance to these patients affected by severe neurological diseases and in some cases controll...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

New migraine clinical trial guidelines

EurekAlert! - Medicine and Health — Tue, 24 Jan 2012 05:00:00 +0100

(SAGE Publications) Experts from the International Headache Societyhave developed new recommendations for conduct of acute and preventive migraine clinical trials. The third edition of Migraine Clinical Trials Guidelines is now available in the IHS journal Cephalalgia, which is published by SAGE. (Source: EurekAlert! - Medicine and Health)

Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)

Molecular Pain — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: These results indicate that IL-6 enhances the excitability of dural afferents likely via ERK-mediated modulation of Nav1.7 and these responses contribute to migraine - related pain behavior in vivo. These data provide a cellular mechanism by which IL-6 in the meninges causes sensitization of dural afferents which may contribute to the pathogenesis of migraine headache. (Source: Molecular Pain)

Safety and efficacy of esreboxetine in patients with fibromyalgia: A 14‐week, randomized, double‐blind, placebo‐controlled, multicenter clinical trial

Arthritis and Rheumatism — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion.Esreboxetine was generally well tolerated and associated with significant improvements in pain, FIQ, PGIC, and fatigue scores compared with placebo. The lack of a dose‐response relationship in both the efficacy and safety analyses suggests that 4‐mg/d esreboxetine would offer clinical benefit with the least risk of drug exposure. (Source: Arthritis and Rheumatism)

Assessing the Incidence of Ciguatera Fish Poisoning with Two Surveys Conducted in Culebra, Puerto Rico, during 2005 and 2006

EHP-in-Press — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: Our estimates, which are consistent with previous studies using similar case-finding, contribute to the overall information available to support public health decision-making about CFP prevention. (Source: EHP-in-Press)

Pharmacokinetic Comparison of 2 Formulations of Anastrozole (1 mg) in Healthy Korean Male Volunteers: A Randomized, Single-Dose, 2-Period, 2-Sequence, Crossover Study.

Clinical Therapeutics — Tue, 24 Jan 2012 05:00:00 +0100

CONCLUSION: The test and reference formulations had similar PK parameters and similar plasma concentration-time profiles. The test formulation of anastrozole met the Korean regulatory criteria (AUC and C(max)) for assuming bioequivalence. ClinicalTrials.gov identifier: NCT01105299. PMID: 22281018 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Development and Validation of a Fluorescence-based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers.

Combinatorial Chemistry and High Throughput Screening — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V Abstract Dysfunction of P/Q-type calcium channels is thought to underlie a variety of neurological diseases. There is evidence that migraine, Alzheimer´s disease, and epilepsy involve a gain-of-function of the channel, leading to abnormal presynaptic vesicle release. P/Q-channel blockers may normalize current flow and consequently lead to an alleviation of disease symptoms. Although the medical need is high, there are no such compounds on the market. Here we describe a high-throughput screen for P/Q-type calcium channel blockers and the confirmation of hits by automated electrophysiology. We generated a HEK293 cell line stably expressing the...

Safety and efficacy of flunarizine in childhood migraine: 11 years’ experience, with emphasis on its effect in hemiplegic migraine

Developmental Medicine and Child Neurology — Tue, 24 Jan 2012 00:48:05 +0100

Aim The aim of this study was to report a single‐centre experience of flunarizine in childhood migraine with focus on safety and efficacy.Method We conducted a retrospective observational audit of 72 individuals (40 male, 32 female; mean age 13y; age range 1y 6mo–17y) at a tertiary paediatric neurology unit between 1998 and 2009. Children were included if they had a diagnosis of migraine and at least one follow‐up assessment and a minimum of 3 months’ treatment with flunarizine.Results Of 102 individuals identified, 30 were excluded for the following reasons: no outcome data (n=13), non‐migraineurs (n=9), missing records (n=4), or inadequate treatment duration (n=4). Of the final cohort (72 individuals), 44 had migraine without aura, 15 had migraine with aura or childhoo...

Well: In Rating Pain, Women Are the More Sensitive Sex

NYT Health — Mon, 23 Jan 2012 22:18:55 +0100

A Stanford study found that women reported higher levels than men suffering the same chronic ailments. (Source: NYT Health)

OnabotulinumtoxinA for Chronic Migraine: Latest EvidenceOnabotulinumtoxinA for Chronic Migraine: Latest Evidence

Medscape Today Headlines — Mon, 23 Jan 2012 19:23:53 +0100

Does this treatment offer new hope for this chronic and debilitating yet all too common condition? Medscape Neurology (Source: Medscape Today Headlines)

Even Mild Dehydration May Cause Emotional, Physical Problems

MedicineNet Migraine General — Mon, 23 Jan 2012 07:00:00 +0100

Title: Even Mild Dehydration May Cause Emotional, Physical ProblemsCategory: Health NewsCreated: 1/21/2012 11:00:00 AMLast Editorial Review: 1/23/2012 (Source: MedicineNet Migraine General)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Safety and tolerability of linagliptin: a pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus

Diabetes, Obesity and Metabolism — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions: This pooled analysis shows that linagliptin is well tolerated, with a low risk of hypoglycaemia. (Source: Diabetes, Obesity and Metabolism)

Airborne Agents, TRP Channels, and Headache

Headache: The Journal of Head and Face Pain — Mon, 23 Jan 2012 05:00:00 +0100

(Source: Headache: The Journal of Head and Face Pain)

OnabotulinumtoxinA for Chronic Migraine

Headache: The Journal of Head and Face Pain — Mon, 23 Jan 2012 05:00:00 +0100

(Source: Headache: The Journal of Head and Face Pain)

White Matter Lesions Progression in Migraine with Aura: A Clinical and MRI Longitudinal Study

Journal of Neuroimaging — Mon, 23 Jan 2012 05:00:00 +0100

CONCLUSIONSOur study demonstrates that in migraine with aura WMLs number can progress over time and suggests an association between aura features and WMLs progression. Studies with a higher number of patients are required to confirm these findings. J Neuroimaging 2012;XX:1–6. (Source: Journal of Neuroimaging)

Third-generation CT has 100% sensitivity and specificity for identifying subarachnoid haemorrhage when it is carried out within 6 h of headache onset

Evidence-Based Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Context A complaint of acute onset headache mandates that subarachnoid haemorrhage (SAH) be excluded as the cause. Because of the less than perfect sensitivity of unenhanced head CT, standard practice is to follow a negative CT with lumbar puncture (LP) to exclude subarachnoid haemorrhage. Improvements in CT technology have raised the question of whether modern third-generation CT scanners are sensitive enough to adequately exclude subarachnoid haemorrhage. Methods This was a prospective multicentre cohort study conducted at 11 university affiliated tertiary care teaching hospitals in Canada between November 2000 and December 2009. Consecutive patients aged 15 or older who presented with acute non-traumatic headache or with syncope associated with a headache were eligible for the study. CT...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Clinical decision rules for the assessment of mild head injury, used in combination with clinical judgment, can inform the use of head imaging

Evidence-Based Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Context CT is currently the primary modality for investigating possible intracranial injury. The benefit of CT scanning for head injury in certain circumstances was recognised more than 30 years ago,1 but only recently have restrictive protocols based on specialist authorisation given way to a liberal approach with unrestricted access to CT scans in most high income countries. Recently, the long-term effects of radiation have been re-emphasised along with the cost of indiscriminate CT scanning, highlighting the need to determine the optimal use of CT scans for minor head injury. Methods In this systematic review, Pandor et al aimed to determine the most appropriate diagnostic imaging strategy for adults and children with minor Glasgow Coma Scale (GCS) 13–15 head injury through a syst...

Posterior Reversible Encephalopathy Syndrome

Journal of Intensive Care Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Posterior reversible encephalopathy syndrome (PRES) is characterized by headache, altered mental status, visual disturbances, and seizures. Radiological features typically include edema of the posterior cerebral regions, especially of the parietooccipital lobes. Atypical imaging features, such as involvement of anterior cerebral regions, deep white matter, and the brain stem are also frequently seen. Vasoconstriction is common in vascular imaging. Different conditions have been associated with PRES, but toxemia of pregnancy, solid organ or bone marrow transplantation, immunosuppressive treatment, cancer chemotherapy, autoimmune diseases, and hypertension are most commonly described. The pathophysiology of PRES is unclear and different hypotheses are being discussed. Posterior reversible en...

OnabotulinumtoxinA for Chronic Migraine.

Headache — Mon, 23 Jan 2012 05:00:00 +0100

Authors: Blumenfeld A, Evans RW PMID: 22268893 [PubMed - as supplied by publisher] (Source: Headache)

Predictors of Headache Before, During, and After Pregnancy: A Cohort Study.

Headache — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions.- A history of headache prior to pregnancy is a strong predictor of headache during and after pregnancy, the latter independent of but compounded by spinal injection. Physicians should attend to prior headache history when making decisions about pain management during and after childbirth. As the lack of formal International Classification of Headache Disorders, 2nd Edition (ICHD-II), headache diagnoses is a limitation of this study, future longitudinal studies should replicate the present design while including headache subtyping consistent with ICHD-II nosology. PMID: 22268840 [PubMed - as supplied by publisher] (Source: Headache)

Airborne Agents, TRP Channels, and Headache.

Headache — Mon, 23 Jan 2012 05:00:00 +0100

Authors: Benemei S, Rossi E, Geppetti P PMID: 22268805 [PubMed - as supplied by publisher] (Source: Headache)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Study finds including unpublished FDA data alters drug effectiveness outcomes

UCSF School of Pharmacy News — Sat, 21 Jan 2012 04:32:09 +0100

RecentResearch Every year U.S. drug regulators approve dozens of new medicines as “safe and effective,” but just how effective are they? How well do they alleviate specific aspects of illness, whether its light sensitivity from migraine headaches or itching from eczema? For answers, many physicians and other health care providers turn to systematic reviews, which combine research about a drug’s efficacy at achieving health outcomes to come up with cumulative estimates. A key tool of these reviews are meta-analyses, which statistically combine the data (e.g., blood pressure measurements, psychiatric test scores, rash cure rates) from multiple studies to seek more accurate answers. But there is a catch to this effort at making more evidence-based medication decisions. Ty...

[Errata] Erratum

Lancet Neurology — Sat, 21 Jan 2012 01:16:38 +0100

Kurth T, Chabriat H, Bousser M-G. Migraine and stroke: a complex association with clinical implications. Lancet Neurol 2012; 11: 92–100—In this Review the citation at the top of the margin on the first page should have read Lancet Neurol2012; 11: 92–100. This correction has been made to the online version as of December 22, 2011. (Source: Lancet Neurology)

Young Man With Fever and Eye Pain

Annals of Emergency Medicine — Fri, 20 Jan 2012 19:16:32 +0100

A 21-year-old man presented with several days of fever, sinus pain, decreased vision, and pain with eye movement. Examination revealed proptosis and periorbital edema/erythema, with an afferent pupillary defect and a visual acuity of hand-motion in the right eye (). A computed tomography (CT) scan showed opacification of the frontal, ethmoid, and maxillary sinuses bilaterally, with right-sided orbital inflammatory changes and a subperiosteal abscess in the superomedial orbit (). The patient began receiving vancomycin, ceftazidime, and metronidazole. He underwent an orbitotomy with subperiosteal abscess drainage and right-sided ethmoidectomy that same day. Abscess cultures grew Staphylococcus aureus and Streptococcus sanguis. Although the external examination showed apparent improvement, th...

Response to Alemtuzumab in FIP1L1/PDGFRA-Negative Hypereosinophilic Myocarditis on Serial Cardiac Magnetic Resonance Imaging

Journal of the American College of Cardiology — Fri, 20 Jan 2012 13:57:13 +0100

A 48-year-old Caucasian woman presented with 2 weeks of myalgias, arthralgias, headache, and neck stiffness. Total peripheral leukocyte count was 80.2 × 109/l with 72% eosinophils. A diagnosis of FIP1L1/PDGFRA-negative hypereosinophilic syndrome was made. The 12-lead electrocardiogram demonstrated inferolateral repolarization abnormalities (A). Serum troponin T was 0.25 ng/ml. Electrocardiography-gated cardiac magnetic resonance imaging demonstrated anterior, anterolateral, inferolateral, and inferior left ventricular (LV) wall thickening, with corresponding abnormal subendocardial T2 signal (C, white arrows) and delayed gadolinium enhancement (E, white arrows). The posterior mitral valve leaflet was tethered. The LV wall motion, right ventricle, and pericardium were normal. Subcutaneous ...

Operant Learning Theory in Pain and Chronic Pain Rehabilitation

Current Pain and Headache Reports — Fri, 20 Jan 2012 07:06:21 +0100

Abstract The application of operant learning theory on chronic pain by Fordyce has had a huge impact on chronic pain research and management. The operant model focuses on pain behaviors as a major component of the pain problem, and postulates that they are subject to environmental contingencies. The role of operant learning in pain behaviors generally has been supported by experimental studies, which are reviewed in the present article. Subsequently, the rationale, goals, and methods of operant behavioral treatment of chronic pain are outlined. Special attention is paid to three therapeutic techniques (graded activity, activity pacing, and time-contingent medication management), which are discussed in detail with regard to their operationalization, effectiveness, and (poss...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Narrowed Artery Condition Often Goes Undiagnosed: Study

MedicineNet Migraine General — Fri, 20 Jan 2012 07:00:00 +0100

Title: Narrowed Artery Condition Often Goes Undiagnosed: StudyCategory: Health NewsCreated: 1/19/2012 6:05:00 PMLast Editorial Review: 1/20/2012 (Source: MedicineNet Migraine General)

EMA recommends suspension of marketing authorisations for meprobamate-containing medicines in the EU

NeLM - News — Fri, 20 Jan 2012 05:00:00 +0100

Source: EMA Area: News The European Medicines Agency (EMA) has recommended the suspension of all marketing authorisations for oral medicines containing meprobamate, a sedative used to treat symptoms of anxiety and related conditions, including anxiety states, alcohol withdrawal, migraine attacks, digestive disorders, muscle tension or cramps, and insomnia. The decision was taken because the risks of these medicines, particularly of serious CNS adverse effects, are greater than their benefits. To ensure prescribers have enough time to determine the most appropriate treatments for patients, the withdrawal from the market will be carried out gradually, within 15 months of the decision. Doctors should consider alternative treatments in line with national recommendations for the con...

HEADACHE (Melilotus Officinalis, Spigelia Anthelmia, Allium Cepa, Belladonna, Bryonia, Cimicifuga Racemosa, Gelsemium Sempervirens, Glonoinum, Magnesia Phosphorica, Nux Vomica,) Liquid [Apotheca Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 20 Jan 2012 05:00:00 +0100

Updated Date: Jan 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Kradjian Imp Co Is Doing An Expanded Recall Of Cedar Tree Brand Tresse Cheese And Cedar Tree Brand Shinglish Cheese Because Of Possible Health Risk

Food and Drug Administration — Fri, 20 Jan 2012 03:07:00 +0100

Kradjian Imp Co, Glendale, CA is recalling 231 Cases, 22Lb / Cs of Cedar Tree brand Tresse Cheese, 16 oz and Cedar Tree brand Shinglish cheese, 16 oz because they have the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women. (Source: Food and Drug Administration)

Negative impact of migraine on quality of life after 4 weeks of treatment in patients with major depressive disorder

Psychiatry and Clinical Neurosciences — Thu, 19 Jan 2012 12:22:35 +0100

Conclusions: Migraine may have a negative impact on the improvement of partial SF‐36 subscales, especially on functional recovery, after acute treatment among outpatients with MDD. Whether additional intervention besides antidepressant treatment for migraine is indicated may need further study. (Source: Psychiatry and Clinical Neurosciences)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Voraxaze Approved to Treat High Levels of Chemo Drug

MedicineNet Migraine General — Thu, 19 Jan 2012 07:00:00 +0100

Title: Voraxaze Approved to Treat High Levels of Chemo DrugCategory: Health NewsCreated: 1/18/2012 6:06:00 PMLast Editorial Review: 1/19/2012 (Source: MedicineNet Migraine General)

New Drug Combo for Hepatitis C Shows Promise

MedicineNet Migraine General — Thu, 19 Jan 2012 07:00:00 +0100

Title: New Drug Combo for Hepatitis C Shows PromiseCategory: Health NewsCreated: 1/18/2012 6:06:00 PMLast Editorial Review: 1/19/2012 (Source: MedicineNet Migraine General)

The Role of Exercise and Types of Exercise in the Rehabilitation of Chronic Pain: Specific or Nonspecific Benefits

Current Pain and Headache Reports — Thu, 19 Jan 2012 06:58:50 +0100

This article summarizes the types of exercise in the rehabilitation of chronic pain patients and provides practical recommendations for the clinician based on empirical and clinical experience. This safe, cost-free, nonpharmacologic way of managing pain has been found to reduce anxiety and depression, improve physical capacity, increase functioning and independence, and reduce morbidity and mortality. Content Type Journal ArticleCategory Psychiatric Management of Pain (MR Clark, Section Editor)Pages 1-9DOI 10.1007/s11916-012-0245-3Authors Amy Burleson Sullivan, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Mail Code U10, 9500 Euclid Avenue, Cleveland, OH 44195, USAJudith Scheman, Neurological Center for Pain, Cleveland Clinic, Mail Code C21, 9500 ...

Five integral steps to support commissioning headache services

HSJ — Thu, 19 Jan 2012 05:00:00 +0100

A framework to support commissioning headache services that champions intermittent care headache clinics led by a GP with a special interest in headache offers important benefits to both patients and commissioners, says Dr David Kernick. (Source: HSJ)

Acclimatisation in trekkers with and without recent exposure to high altitude

European Journal of Applied Physiology — Wed, 18 Jan 2012 06:59:26 +0100

Abstract In mountaineers, recent altitude exposure has been shown to improve climbing performance and clinical outcomes during re-exposure to high altitude. However, the timing of previous altitude exposure has not been clearly reported and previous findings might be driven by individuals who were still acclimatised at the time of re-exposure. Our goal was to determine whether recent altitude exposure would confer an advantage even in individuals who had de-acclimatised for ≥1 week before being re-exposure. Low-altitude natives kept a daily trekking log throughout 7- to 8-day trek from Lukla (2,840 m) to Gokyo Ri (5,360 m). Trekkers with recent altitude exposure (re-acclimatisers, RA; n = 20) walked 20% faster (p < 0.01), reported low...

MedWorm Sponsor Message: Find the best January Sales in the UK.

D‐Dimer Testing in the Diagnosis of Cerebral Vein Thrombosis: a Systematic Review and a Meta‐Analysis of the Literature

Journal of Thrombosis and Haemostasis — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions: our findings suggest that D‐dimer may be a useful diagnostic tool in the management of patients with suspected CVT. Future prospective studies are warranted to confirm our preliminary findings. (Source: Journal of Thrombosis and Haemostasis)

Exanthematous drug eruption due to valsartan.

Cutaneous and Ocular Toxicology — Wed, 18 Jan 2012 05:00:00 +0100

Discussion and conclusion: Most common antihypertensive agents including diuretics, beta blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors have many cutaneous side effects. However, there are a few reports about the cutaneous side effects of ARBs. Physicians should be aware of the cutaneous side effects of this commonly used agent and valsartan should be considered as a triggering factor of an exanthematous drug reactions. PMID: 22257082 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)

Melatonin withdrawal: Migraine with aura: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Trazodone: Dizziness, headache and nausea: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

(Source: Reactions)

Mother discovers her family's illness comes from insect bite 20 years ago

the Mail online | Health — Tue, 17 Jan 2012 18:27:28 +0100

Adelle Huckins, from Cleveland, (pictured) has been blighted by a range of health problems including migraines, severe fatigue, sickness, hearing difficulties and a drooping left eye. (Source: the Mail online | Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Inter-critical and critical excessive daily sleepiness in episodic migraine patients

Neurological Sciences — Tue, 17 Jan 2012 07:10:55 +0100

The objective of this study was to determine the relationship between sleepiness and migraine in the intercritical period and to evaluate the time course of critical drowsiness during the attacks. One hundred patients fulfilling IHCD 2nd (2004) criteria for migraine without aura were compared to 100 healthy subjects. Habitual excessive daily sleepiness, evaluated by means of Epworth Sleepiness Scale, was not more frequent in patients with episodic migraine than in controls (12% migraineurs vs. 8% controls, NS). The analysis of critical sleepiness by means of Stanford Sleepiness Scale (SSS) revealed a beginning of sleepiness increase before the attack onset, starting 12 h before, a peak of SSS values at the migraine attack onset and then a gradual decrease to reach baseline value...

Interictal Pain in Primary Headache Syndromes

Current Pain and Headache Reports — Tue, 17 Jan 2012 07:06:33 +0100

Abstract Primary headache disorders are generally characterized by the pain, time course, and associated symptoms of their attacks, but often are accompanied by milder interictal pain. Patients with chronic migraine, chronic tension-type headache, hemicrania continua, and new daily-persistent headache have constant pain more often than not. Patients with trigeminal autonomic cephalalgias such as cluster headache commonly have interictal pain as well, usually much milder and unilateral to the side of attacks. Even those with rare headache types, including hypnic headache and trigeminal neuralgia, commonly have interictal pain. This review describes the incidence of interictal pain in primary headache disorders and suggests the significance and biological meanings of this pa...

Coffee helps people focus, causes headache

Health News - UPI.com — Tue, 17 Jan 2012 06:20:20 +0100

DALLAS, Jan. 17 (UPI) -- Coffee may clear mental cobwebs and help people concentrate -- but it may also cause unwanted headaches -- a U.S. researcher says. (Source: Health News - UPI.com)

Atypical clinical and imaging manifestation in neurocysticercosis

Annals of Indian Academy of Neurology — Tue, 17 Jan 2012 05:00:00 +0100

L Dayananda, C Kesavadas, Bejoy Thomas, R Neelima, VV RadhakrishnanAnnals of Indian Academy of Neurology 2011 14(4):295-297A 20-year-old man presented with left-sided headache and seizures of three years duration. Conglomerate ring-enhancing lesions were seen in the first magnetic resonance imaging study. He was initially treated with anticonvulsants for two years. Because the symptoms and the lesions were persisting, antitubercular treatment was added. He was asymptomatic after antitubercular treatment despite persisting lesion. Lesion showed exuberant ring enhancement with increased perfusion. Because the lesion was persisting even after 24 months of antitubercular treatment, excision was considered. Lesionectomy was done and histopathology reported meningoencephalitis secondary to neuro...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Epidemiology of dengue infections in Kassala, Eastern Sudan

Journal of Medical Virology — Mon, 16 Jan 2012 07:19:43 +0100

AbstractEighty‐one (71.7%) out of 113 patients had confirmed dengue infection (using ELISA IgM serology) at Kassala, Eastern Sudan during the period of August through November 2010. According to the WHO criteria, dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) were observed in 30.9, 58, and 11.1% of these patients, respectively. The mean age of these 81 patients was 25.5 years. Male:female ratio was 1.8:1. Various symptoms including fever (100%), headache (75.3%), vomiting (55.6%), nausea (53.1%), and backache (30.9%) were observed among these patients. Thrombocytopenia (<100/109 platelets/L), and leucopenia (WBC count <4,000 × 109 cells/L) and hemoconcentration (hematocrit >45) were reported in 86.4, 69.1, and 67.9% of the patients, respe...

Novel pulsatile cerebrospinal fluid model to assess pressure manometry and fluid sampling through spinal needles of different gauge: support for the use of a 22 G spinal needle with a tapered 27 G pencil-point tip

British Journal of Anaesthesia — Mon, 16 Jan 2012 05:00:00 +0100

Conclusions A 22/27 G tapered spinal needle has similar flow properties to the 22 G needle, despite a 27 G tip. (Source: British Journal of Anaesthesia)

Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3

Neurology — Mon, 16 Jan 2012 05:00:00 +0100

Conclusions: Our data suggest the occurrence of common susceptibility loci for epilepsy and migraine on chromosomes 14q12-q23 and 12q24.2-q24.3, implicating a shared genetic etiology for these 2 diseases. (Source: Neurology)

Atypical Neurofibroma and Osteosclerotic Metastasis

Journal of Biophysics — Mon, 16 Jan 2012 03:35:01 +0100

35-year-old male presented with multiple swellings in left leg, headache, weakness of limbs for 4 months, and blurring of vision for the last 15 days. On examination, he was pale, cachexic with generalized lymphadenopathy and lower motor neuron type weakness of limbs sparing right upper limb. Blood investigations showed anemia with high alkaline phosphatase. Chest radiograph revealed osteosclerotic metastatic lesion in humerus. Biopsy of leg lesion revealed atypical neurofibroma. Computed tomography (CT) of thorax revealed osteoblastic metastasis. Bone marrow aspiration showed cells with round to oval nuclei, fine granular chromatin with large central prominent nucleoli and eosinophilic cytoplasm with acini formation. Magnetic resonance imaging (MRI) of brain and spinal cord defined metast...

Dermatitis herpetiformis, primary hypothyroidism and pituitary mass mimicking macroadenoma regression after treatment with thyroxin, corticosteroids and dapsone

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

We report a case of 15-year-old girl who was diagnosed as a case of pituitary macroadenoma on computed tomography and magnetic resonance imaging (MRI) scans for her complains of diminished vision in the left eye and headache. On investigation she was found to have optic atrophy of left eye and primary hypothyroidism. She was started on thyroxin therapy in October 2008 and planned for transcranial excision of the tumor. Just before the date for planned surgery she developed mildly itchy vesico-bullous rash and the surgery was postponed. On histopathology and immunoflourescence studies it was confirmed to be the rash of dermatitis herpetiformis (DH) and treatment was started with corticosteroids in the last week of December 2008 and dapsone was added from mid January 2009. The lesions respon...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Valproate-induced encephalopathy with predominant pancerebellar syndrome

Indian Journal of Pharmacology — Sat, 14 Jan 2012 05:00:00 +0100

Rajesh Verma, Prakash KoriIndian Journal of Pharmacology 2012 44(1):129-130Valproate-induced hyperammonemic encephalopathy is a rare event clinically characterized by impaired sensorium, vomiting, headache, seizures and focal neurological deficits. The pathogenesis of this dreadful complication is not well understood, although hyperammonemia has been implicated in causation of encephalopathy. In this submission, we have highlighted a case of valproate-induced encephalopathy who presented mainly with bilateral cerebellar features and generalized slowing on electroencephalogram. High index of suspicion of valproate-induced hyperammonemic encephalopathy is required if diffuse ataxia is present as it is a potentially reversible clinical disorder. (Source: Indian Journal of Pharmacology)

Bevacizumab: Hypertension, and first report of amenorrhoea and migraines: 2 case reports

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Attitudes of a group of Brazilian orthodontists towards the diagnosis and management of primary headache (migraine): an electronic-based survey

Journal of Applied Oral Science — Fri, 13 Jan 2012 21:27:33 +0100

CONCLUSIONS: The majority of participants proposed inadequate therapies, and 51% suggested orthodontic correction of occlusion, including orthognathic surgery. Educational activities on migraine should also target orthodontists. (Source: Journal of Applied Oral Science)

Acupuncture May Have Late Effects in Migraine ProphylaxisAcupuncture May Have Late Effects in Migraine Prophylaxis

Medscape Today Headlines — Fri, 13 Jan 2012 19:18:17 +0100

A new study has found no significant difference between traditional acupuncture and sham treatment in the number of days with migraine, but there were apparent late effects. Medscape Medical News (Source: Medscape Today Headlines)

One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults

The Journal of Headache and Pain — Fri, 13 Jan 2012 17:19:44 +0100

Abstract Several studies have shown that the prevalence of migraine and tension-type headache (TTH) varied between different geographical regions. Therefore, there is a need of a nationwide prevalence study for headache in our country, located between Asia and Europe. This nationwide study was designed to estimate the 1-year prevalence of migraine and TTH and analyse the clinical features, the impact as well as the demographic and socio-economic characteristics of the participant households in Turkey. We planned to investigate 6,000 representative households in 21 cities of Turkey; and a total of 5,323 households (response rate of 89%) aged between 18 and 65 years were examined for headache by 33 trained physicians at home on the basis of the diagnostic criteria of th...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Effect of CGRP and sumatriptan on the BOLD response in visual cortex

The Journal of Headache and Pain — Fri, 13 Jan 2012 17:19:42 +0100

Abstract To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 μg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0....

Exercise, Talk Therapy by Phone May Help Relieve Fibromyalgia Pain

MedicineNet Migraine General — Fri, 13 Jan 2012 07:00:00 +0100

Title: Exercise, Talk Therapy by Phone May Help Relieve Fibromyalgia PainCategory: Health NewsCreated: 1/13/2012 11:00:00 AMLast Editorial Review: 1/13/2012 (Source: MedicineNet Migraine General)

Acupuncture May Be Effective for Migraines

MedicineNet Migraine General — Fri, 13 Jan 2012 07:00:00 +0100

Title: Acupuncture May Be Effective for MigrainesCategory: Health NewsCreated: 1/13/2012 11:01:00 AMLast Editorial Review: 1/13/2012 (Source: MedicineNet Migraine General)

EXTRA STRENGTH HEADACHE RELIEF (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [CHAIN DRUG MARKETING ASSOCIATION INC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 13 Jan 2012 05:00:00 +0100

Updated Date: Jan 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EXTRA STRENGTH HEADACHE RELIEF (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [DOLGENCORP, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 13 Jan 2012 05:00:00 +0100

Updated Date: Jan 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Increased risk of multiple sclerosis among women with migraine in the Nurses' Health Study II

Multiple Sclerosis — Fri, 13 Jan 2012 05:00:00 +0100

Conclusions: Using a large, cohort of women-nurses, history of migraine was associated with an increased risk of MS. However, the difference in absolute risk of MS in migraineurs and non-migraineurs was small. (Source: Multiple Sclerosis)

Na+,K+-ATPase Mutations Causing Familial Hemiplegic Migraine [Membrane Biology]

Journal of Biological Chemistry — Fri, 13 Jan 2012 05:00:00 +0100

The neurological disorder familial hemiplegic migraine type II (FHM2) is caused by mutations in the α2-isoform of the Na+,K+-ATPase. We have studied the partial reaction steps of the Na+,K+-pump cycle in nine FHM2 mutants retaining overall activity at a level still compatible with cell growth. Although it is believed that the pathophysiology of FHM2 results from reduced extracellular K+ clearance and/or changes in Na+ gradient-dependent transport processes in neuroglia, a reduced affinity for K+ or Na+ is not a general finding with the FHM2 mutants. Six of the FHM2 mutations markedly affect the maximal rate of phosphorylation from ATP leading to inhibition by intracellular K+, thereby likely compromising pump function under physiological conditions. In mutants R593W, V628M, and M731T, the...

A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome.

Vaccine — Fri, 13 Jan 2012 05:00:00 +0100

Authors: Boudreau EF, Josleyn M, Ullman D, Fisher D, Dalrymple L, Sellers-Myers K, Loudon P, Rusnak J, Rivard R, Schmaljohn C, Hooper JW Abstract Candidate DNA vaccines for hemorrhagic fever with renal syndrome expressing the envelope glycoprotein genes of Hantaan (HTNV) or Puumala (PUUV) viruses were evaluated in an open-label, single-center Phase 1 study consisting of three vaccination groups of nine volunteers. The volunteers were vaccinated by particle-mediated epidermal delivery (PMED) three times at four-week intervals with the HTNV DNA vaccine, the PUUV DNA vaccine or both vaccines. At each dosing, the volunteers received 8μg DNA/4mg gold. There were no study-related serious adverse events, and all injection site pain was graded as mild. The most commonly reported systemic ...

Acupuncture May Be Effective for Migraines

WebMD Health — Thu, 12 Jan 2012 05:00:00 +0100

Acupuncture helps reduce days with migraines and may have lasting effects, according to a new study published in the Canadian Medical Association Journal. (Source: WebMD Health)

EXTRA STRENGTH HEADACHE RELIEF (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [WOONSOCKET PRESCRIPTION CENTER,INCORPORATED]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 12 Jan 2012 05:00:00 +0100

Updated Date: Jan 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Idiopathic Thoracic Spinal Cord Herniation: Retrospective Analysis Supporting a Mechanism of Diskogenic Dural Injury and Subsequent Tamponade [SPINE]

American Journal of Neuroradiology — Thu, 12 Jan 2012 05:00:00 +0100

CONCLUSIONS: Our analysis of published imaging indicates that tSCH occurs preferentially at spinal levels and with imaging findings consistent with dural injury that support the proposed etiology of this disorder. (Source: American Journal of Neuroradiology)

Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids.

Biotechnology Advances — Thu, 12 Jan 2012 05:00:00 +0100

Authors: Hulvová H, Galuszka P, Frébortová J, Frébort I Abstract Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, d-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000kg, of which field cultivation contributed about 50%. This review covers the recent advances in underst...

Arthritis, Fever, and Frontal Headache: Make the DiagnosisArthritis, Fever, and Frontal Headache: Make the Diagnosis

Medscape Today Headlines — Wed, 11 Jan 2012 20:10:22 +0100

Dr. Jonathan Kay discusses the case of a woman with juvenile rheumatoid arthritis and uveitis who developed headache and a fever. The diagnosis might surprise you. Medscape Rheumatology (Source: Medscape Today Headlines)

Posterior reversible encephalopathy syndrome: a case following reversible cerebral vasoconstriction syndrome masquerading as subarachnoid haemorrhage

Acta Neurochirurgica — Wed, 11 Jan 2012 17:57:05 +0100

Abstract Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic clinico-radiological diagnosis typically presenting with headache, encephalopathy and visual disturbance accompanied by a unique neuroradiological pattern of symmetrical parieto-occipital vasogenic oedema. Here we present the case of a 51-year-old woman who presented to hospital following a thunderclap headache, initially thought to be secondary to a subarachnoid haemorrhage (SAH). A tiny anterior choroidal artery aneurysm was demonstrated on cerebral angiogram. At surgical clipping, no evidence of haemorrhage was observed. Post-operatively, the patient developed delayed right-sided hemiparesis, managed with aggressive hypertensive treatment, and later, with onset of septicaemia, central visual lo...

What's New in Migraine Therapy?

Consultant Live — Wed, 11 Jan 2012 12:00:00 +0100

(Source: Consultant Live)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Short answer question case series: diagnosis and management of glaucoma

Emergency Medicine Journal — Wed, 11 Jan 2012 05:00:00 +0100

Case vignette A 40-year-old woman with history of hypertension and migraines presents with a complaint of headache. Two days prior to presentation she began to experience a left-sided, throbbing headache that radiated to the right and was accompanied by blurring of left eye vision and nausea. The blurred vision and headache were exacerbated by bright light, consistent with prior migraine attacks. She took her usual dose of naproxen with resolution of her nausea but still had a mild headache and blurred left eye vision. Two hours prior to presentation she walked outside and experienced worsening of her headache upon exposure to the sunlight, but without concomitant change in her vision or nausea. Aleve did not improve her symptoms, so she decided to present to the emergency department. Her ...

Highlights from this issue

Archives of Disease in Childhood - Education and Practice — Wed, 11 Jan 2012 05:00:00 +0100

Welcome to the February Epistle, and to an edition of Education and Practice which looks – and perhaps feels – a little different, but which contains most of the sections you are familiar with. Here is a summary of the changes. First, those of you reading this on paper will have noticed the new cover; this is traditional with a change in Editor in Chief and because we publish on even months you would have also seen the redesign on the blue journal and F&N first. Next, those of you reading on paper or as downloaded pdfs, we have changed the way the articles are laid out on the page. We think this looks better on the page, and hope that the papers feel a bit better when you read them. Ideally of course, you will not notice anything. Finally, one of the bugbears of a journal i...

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions

BJU International — Wed, 11 Jan 2012 05:00:00 +0100

What's known on the subject? and What does the study add?Nearly 90% of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) report sensitivities to a wide variety of dietary comestibles. Current questionnaire‐based literature suggests that citrus fruits, tomatoes, vitamin C, artificial sweeteners, coffee, tea, carbonated and alcoholic beverages, and spicy foods tend to exacerbate symptoms, while calcium glycerophosphate and sodium bicarbonate tend to improve symptoms. At present we recommend employing a controlled method to determine dietary sensitivities, such as an elimination diet, in order to identify sensitivities while at the same time maintain optimal nutritional intake.We review current literature with regard to diet's effect upon IC/BPS and common comorbidities (ir...

Inducible nitric oxide synthase haplotype associated with migraine and aura.

Molecular and Cellular Biochemistry — Wed, 11 Jan 2012 05:00:00 +0100

Authors: de O S Mansur T, Gonçalves FM, Martins-Oliveira A, Speciali JG, Dach F, Lacchini R, Tanus-Santos JE Abstract Migraine is a complex neurological disorder with a clear neurogenic inflammatory component apparently including enhanced nitric oxide (NO) formation. Excessive NO amounts possibly contributing to migraine are derived from increased expression and activity of inducible NO synthase (iNOS). We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and G2087A-rs2297518) are associated with migraine with or without aura. We studied 142 healthy women without migraine (control group) and 200 women with migraine divided into two groups: 148 with migraine without aura (MWA) and 52 with aura (MA). Genotypes were determi...

Migraine - The Enigma Of Trial Results

Health News from Medical News Today — Tue, 10 Jan 2012 17:00:00 +0100

In order to find out the effect of acupuncture compared with sham acupuncture in treating migraines, a team of investigators carried out a randomized controlled human trial. 480 individuals at 9 hospitals in China who experienced migraines for over one year, with two or three migraines in the 3 months prior to the investigation, were enrolled to participate in the study. The researchers randomly assigned the volunteers to four groups. Those in one group received sham acupuncture, while participants in the other three groups received different types of acupuncture... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Interactions between migraine and tension-type headache and alcohol drinking, alcohol flushing, and hangover in Japanese

The Journal of Headache and Pain — Tue, 10 Jan 2012 16:49:44 +0100

Abstract The aim of the study was to investigate associations between headache types and alcohol drinking, alcohol flushing, and hangover. Alcohol consumption is inhibited by the presence of inactive aldehyde dehydrogenase-2 (ALDH2) whose carriers are susceptible to alcohol flushing and hangovers. We conducted a cross-sectional study of the 2,577 subjects (men/women: 1,018/1,559) who reported having ever experienced headaches unrelated to common colds and alcohol hangovers among 5,408 (2,778/2,630) Tokyo health checkup examinees. We used a questionnaire inquiring about current and past facial flushing after drinking a glass of beer which identifies the presence of inactive ALDH2 with a sensitivity and specificity of approximately 90%. Based on ICHD-II criteria migraine was...

Health roundup: Heart attacks, migraines

USATODAY.com Health — Tue, 10 Jan 2012 15:08:53 +0100

Mourning raises heart attack risk, nicotine patches might not help smokers but may have other uses, and a penis tattoo is a bad idea. (Source: USATODAY.com Health)

Power of acupuncture to ease migraines questioned in study

USATODAY.com Health — Tue, 10 Jan 2012 14:11:22 +0100

"Sham" acupuncture worked almost as well on migraine patients as three types of traditional acupuncture, a new study says. (Source: USATODAY.com Health)

Difficulties In Treating Migraines Highlighted By Two Randomized Controlled Trials

Health News from Medical News Today — Tue, 10 Jan 2012 11:00:00 +0100

Acupuncture and sham acupuncture appear equally effective in treating migraines, according to a clinical trial published in CMAJ (Canadian Medical Association Journal). An international team of researchers conducted a randomized controlled trial to determine the effect of acupuncture compared with sham acupuncture in treating migraines in 480 patients at nine hospitals in China. The patients were randomly assigned to four groups, including one sham acupuncture group and three groups receiving different types of acupuncture... (Source: Health News from Medical News Today)

Health Tip: Is My Neck Pain Serious?

MedicineNet Migraine General — Tue, 10 Jan 2012 07:00:00 +0100

Title: Health Tip: Is My Neck Pain Serious?Category: Health NewsCreated: 1/10/2012 8:05:00 AMLast Editorial Review: 1/10/2012 (Source: MedicineNet Migraine General)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Bufferin, Excedrin, NoDoz, Gas-X Recalled

MedicineNet Migraine General — Tue, 10 Jan 2012 07:00:00 +0100

Title: Bufferin, Excedrin, NoDoz, Gas-X RecalledCategory: Health NewsCreated: 1/10/2012 11:01:00 AMLast Editorial Review: 1/10/2012 (Source: MedicineNet Migraine General)

How to identify stroke mimics in patients eligible for intravenous thrombolysis?

Journal of Neurology — Tue, 10 Jan 2012 06:48:21 +0100

Abstract Since decision-making for thrombolysis in acute stroke settings is restricted to a limited time window and based on clinical assessment and CT findings only, thrombolysis is sometimes applied to patients with a final diagnosis other than a stroke. From a prospectively collected stroke/MRI data bank (2004–2010) with 648 suspected ischemic stroke patients treated with rtPA, we identified patients without evidence of acute infarction on follow-up MRI and a final diagnosis other than a stroke or acute cerebrovascular event. We compared demographics, symptoms, complications, and outcome of patients with stroke mimics (SM) to those with acute infarction. In 42 patients, an SM was diagnosed: seizures in 20, conversion disorder in seven, dementia in six, migraine in thr...

Acute Epidural Spinal Hemorrhage from Vasculitis: Resolution with Immunosuppression

Neurocritical Care — Tue, 10 Jan 2012 06:41:25 +0100

Conclusions Immunomodulating therapy should be considered in the management of select patients with spinal vasculitis which may lead to improved clinical outcome and potentially disease resolution. Content Type Journal ArticleCategory Practical PearlPages 1-5DOI 10.1007/s12028-011-9667-8Authors Jeffrey T. Jacob, Department of Neurologic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USAShota Tanaka, Department of Neurologic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USAChristopher P. Wood, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USAEelco F. Wijdicks, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USAGiuseppe Lanzino, Department of N...

ALLERGY/SINUS HEADACHE (Acetaminophen, Diphenhydramine Hcl And Phenylephrine Hcl) Tablet [DOLGENCORP, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 Jan 2012 05:00:00 +0100

Updated Date: Jan 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Attitudes to seeking medical assistance - variations depending on social background?

Tidsskrift for den Norske Laegeforening — Tue, 10 Jan 2012 05:00:00 +0100

Attitudes to seeking medical assistance - variations depending on social background? Tidsskr Nor Laegeforen. 2012 Jan 10;132(1):36-40 Authors: Klüwer-Trotter B, Lian OS Abstract Background. Increasing socio-economic inequalities in health, within a country as well as internationally, give rise to a timely question: Are there any systematic differences between people from differing social backgrounds with regard to their attitude to seeking professional medical assistance when experiencing physical problems of varying kinds? Material and method. The data material is taken from the Norwegian part of the cross-sectional survey ’European Social Survey' (2004-2005). The analyses are based on data from personal interviews with 741 men and 694 women aged 25-75. The cor...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Why does cold weather help cold and flu viruses?

The Irish Times - Health — Tue, 10 Jan 2012 00:16:39 +0100

THAT’S THE WHY:“Wrap up or you’ll catch your death.” Why is it that we tend to link cold weather, or even just being cold, with catching the common cold or the flu, complete with a stuffed-up nose, headache and attendant misery? (Source: The Irish Times - Health)

Protein changes identified in early-onset Alzheimer's

UCLA Newsroom: Health Sciences — Mon, 09 Jan 2012 21:00:00 +0100

In this study, we've identified chemical changes occurring in the brains of persons destined to develop Alzheimer's disease 10 years or more prior to the expression of symptoms. By studying the cerebrospinal fluid of persons developing Alzheimer's disease at a relatively young age with cutting-edge protein chemical techniques, we found changes in markers reflecting inflammation as well as the breakdown of synapses. "This provides potential new targets for drug interventions, and it helps elucidate the degree to which FAD and late-onset Alzheimer's are similar and to what degree they are distinct. Such knowledge may ultimately allow us to tailor our treatments to individuals, depending on the 'type' of Alzheimer's they have." The study, funded in part by the pharmaceutical com...

Anti-N-methyl-d-aspartate receptor encephalitis with minimal cortical impairment

Neurological Sciences — Mon, 09 Jan 2012 19:37:01 +0100

Abstract Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has been recently identified as a fulminant encephalopathy, presenting with a variety of symptoms including behavioral change, amnesia and seizures suggesting cortical gray matter involvement. A 42-year-old woman presented with acute-onset clinical and magnetic resonance imaging (MRI) findings indicating brainstem and diencephalon involvement. Her neuropsychological examination revealed mild frontal dysfunction with no memory impairment. Detailed diagnostic workup proved negative except for serum/cerebrospinal fluid (CSF) NMDAR-antibodies and increased activity in inguinal and pelvic lymph nodes on positron-emission tomography (PET) examination. The symptoms and MRI findings completely resolved following ster...

Mixed Results for Migraine Tx, Preventive Efforts (CME/CE)

MedPage Today State Required CME — Mon, 09 Jan 2012 18:56:06 +0100

(MedPage Today) -- An intervention promoting prophylactic drug treatment failed to reduce the frequency or severity of migraine attacks, a randomized study indicated, while a separate trial of acupuncture found that it was significantly beneficial -- but not much more so than sham acupuncture. (Source: MedPage Today State Required CME)

Acupuncture little better than "sham" for migraine

Reuters: Health — Mon, 09 Jan 2012 17:26:18 +0100

NEW YORK (Reuters Health) - Traditional Chinese acupuncture seems little better than a "sham" version of the procedure when it comes to preventing migraines, a study published Monday suggests. (Source: Reuters: Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Power of Acupuncture to Ease Migraines Questioned in Study

MedlinePlus Health News — Mon, 09 Jan 2012 17:00:00 +0100

Precise needle location may be less important than thought, expert says Source: HealthDay Related MedlinePlus Pages: Acupuncture, Migraine (Source: MedlinePlus Health News)

Abstracts.

Headache — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Taylor FR, Kaniecki RG, Landy SH PMID: 22229869 [PubMed - as supplied by publisher] (Source: Headache)

Transdermal Sumatriptan for Acute Treatment of Migraineurs With Baseline Nausea.

Headache — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions.- Transdermal sumatriptan is superior to oral triptans for migraine patients whose baseline nausea causes them to delay or avoid acute treatment. PMID: 22229837 [PubMed - as supplied by publisher] (Source: Headache)

Harry Potter and Nummular Headache.

Headache — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Mohen SA, Robbins MS PMID: 22229808 [PubMed - as supplied by publisher] (Source: Headache)