MedWorm: Osteoporosis

Halting bone-building osteoporosis drug use cuts risk for additional atypical femur fracture in half

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(American Academy of Orthopaedic Surgeons) There is growing evidence that supports an association between atypical fractures of the femur- a rare break of the thigh bone, typically without trauma - and the use of bisphosphonates, drugs proven to enhance bone density and reduce fracture incidence caused by osteoporosis. (Source: EurekAlert! - Medicine and Health)

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Do gastric adverse events influence the choice of bisphosphonate for the treatment of osteoporosis?

NeLM - Medicines Q and A — Wed, 08 Feb 2012 05:00:00 +0100

Source: Regional Drug and Therapeutics Centre Area: Evidence > Medicines Q & A The bisphosphonates are a group of drugs used to reduce bone turnover in conditions including osteoporosis, Paget's disease, and bone malignancies. The therapeutic effect is achieved by inhibiting bone resorption. As a group the bisphosphonates are generally well tolerated, but have a well documented adverse effect (AE) profile, and gastrointestinal effects are a known issue. Strict administration requirements have been introduced to reduce the risk of oesophageal AEs, and inability to meet these requirements is considered a contraindication to treatment. There have been reports of pain, nausea, vomiting and gastric ulcers associated with bisphosphonate use. (Source: NeLM - ...

Heart Failure, Osteoporosis Go 'Hand-In-Hand'

MedlinePlus Health News — Tue, 07 Feb 2012 22:00:00 +0100

Cardiac condition raises the risks of falls and may contribute to bone-density loss Source: HealthDay Related MedlinePlus Pages: Heart Failure, Osteoporosis (Source: MedlinePlus Health News)

Researchers develop method of directing stem cells to increase bone formation and bone strength (EurekAlert, 5 February 2012)

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

US researchers have developed a technique to promote bone growth in a mouse model of osteoporosis by stimulating the migration of stem cells to the bone, reporting their findings in Nature Medicine. Full article (Source: Society for Endocrinology)

Heart Failure, Osteoporosis Go ‘Hand-in-Hand’: Researchers

The Doctors Lounge - Cardiology — Tue, 07 Feb 2012 05:00:00 +0100

Cardiac condition raises the risks of falls and may contribute to bone-density loss (Source: The Doctors Lounge - Cardiology)

Green Tea Protects Against Functional Disability Linked To Aging

Health News from Medical News Today — Mon, 06 Feb 2012 21:00:00 +0100

Regular green tea drinkers have a lower risk of developing functional disability, researchers from Tohoku University Graduate School of Medicine, Sendai, Japan, reported in the American Journal of Clinical Nutrition. Functional disability refers to problems with daily chores and activities, such as bathing or dressing. As background information, the authors explained that prior studies had found that consuming green tea reduced the risk of diseases associated with functional disability, such as osteoporosis, cognitive impairment and stroke... (Source: Health News from Medical News Today)

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Osteoporosis & Bone Mass

About.com Eating Disorders — Mon, 06 Feb 2012 05:00:00 +0100

Given the knowledge that high peak bone density reduces osteoporosis risk later in life, it makes sense to pay more attention to those factors that affect peak bone mass. (Source: About.com Eating Disorders)

Link Between Heart Failure And Thinner Bones And Fractures

Health News from Medical News Today — Sun, 05 Feb 2012 08:00:00 +0100

Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Osteoporosis and heart failure are common, chronic and costly conditions that share common etiologic factors like older age, post-menopausal status and diabetes... (Source: Health News from Medical News Today)

Book: The Complete Book of Bone Health

Sound Medicine — Sun, 05 Feb 2012 05:00:00 +0100

And finally today, osteoporosis is the most common health problem women face today. In fact, one in five women will die within a year of breaking a hip. The good news: There are things women can do to bolster their bones. Host Barbara Lewis interviews bone health expert Diane Schneider, MD, who discusses her new book The Complete Book of Bone Health. Dr. Schneider started a non-profit orga.... (Source: Sound Medicine)

Bone Density Testing - ASBMR Response To NEJM Article

Health News from Medical News Today — Sat, 04 Feb 2012 08:00:00 +0100

The recently reported study on bone density testing in the New England Journal of Medicine (NEJM) may have inadvertently resulted in confusion about the use and recommended frequency of an important diagnostic tool used for osteoporosis, a very serious condition that affects many women... (Source: Health News from Medical News Today)

Diet Strategies To Manage Hot Flash

HealthCastle.com Nutrition Tips - written by Registered Dietitians — Sat, 04 Feb 2012 00:20:58 +0100

(HealthCastle.com) Hot flashes seem to be a personal experience. Many women we talked to tried various diet remedies and supplements but results are often inconsistent. Let's look at some common diet solutions for hot flashes and their scientific evidence. A Diet to Manage Hot Flash Avoid the following food items in your diet. Most women found these foods make hot flashes worse. read more (Source: HealthCastle.com Nutrition Tips - written by Registered Dietitians)

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Erratum to: Ethnic differences in composite indices of femoral neck strength

Osteoporosis International — Fri, 03 Feb 2012 17:11:21 +0100

Content Type Journal ArticleCategory ErratumPages 1-2DOI 10.1007/s00198-011-1887-4Authors S. Ishii, Geriatric Research, Education and Clinical Center (GRECC), VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building 220, Room 302, Los Angeles, CA 90073, USAJ. A. Cauley, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A524 Crabtree, Pittsburgh, PA 15260, USAG. A. Greendale, Department of Medicine/Division of Geriatrics, David Geffen School of Medicine at UCLA, 10933 Le Conte Ave, Los Angeles, CA 90095, USAM. E. Danielson, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A524 Crabtree, Pittsburgh, PA 15260, USAN. Safaei Nili, Department of Medicine/Division ...

Association of T869C gene polymorphism of transforming growth factor-β1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women.

Genetics and Molecular Research — Fri, 03 Feb 2012 11:24:05 +0100

Association of T869C gene polymorphism of transforming growth factor-β1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women. Genet Mol Res. 2012;11(1):87-99 Authors: Utennam D, Tungtrongchitr A, Phonrat B, Tungtrongchitr R, Preutthipan S Abstract Osteoporosis is the most common metabolic bone disease; it is an important health problem among postmenopausal women. We evaluated the association of three polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density (BMD) serum TGF-β1 levels in 278 postmenopausal female osteopenia/osteoporosis subjects and 95 postmenopausal female control subjects. Serum TGF-β1 levels were significantly lower in osteopenia/osteoporosis subjects than in control subjects...

US Drug Watchdog Expands Its Initiative For Women With A Femur...

PRWeb: Medical Pharmaceuticals — Fri, 03 Feb 2012 06:24:02 +0100

The US Drug Watchdog says, "We are becoming increasing concerned that women, who have had a femur break, after using the osteoporosis drug called Fosamax are signing on with a law firms, that...(PRWeb January 31, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9147653.htm (Source: PRWeb: Medical Pharmaceuticals)

Frequent bone scans for osteoporosis revealed as yet another medical scam

NaturalNews.com — Fri, 03 Feb 2012 06:00:00 +0100

There seems to be a scan for almost every medical condition these days. But not all of these scans have been proven safe or effective, or even necessary for that matter. A new study published in the New England Journal of Medicine (NEJM) has revealed that bone mineral... (Source: NaturalNews.com)

New study to assess 3 simple, cost-effective strategies to promote healthy aging

EurekAlert! - Social and Behavioral Science — Fri, 03 Feb 2012 05:00:00 +0100

(International Osteoporosis Foundation) A new international study announced today by the University of Zurich hopes to provide definitive evidence that three effective, affordable and safe measures can be taken to significantly reduce the burden of chronic diseases in the elderly. The DO-HEALTH study will be Europe's largest healthy aging study. It expects to provide solid evidence for the efficacy and safety of three simple preventive interventions: Vitamin D, omega-3 fatty acids and a simple home exercise program. (Source: EurekAlert! - Social and Behavioral Science)

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Evaluation of educational program on osteoporosis awareness and prevention among nurse students in China

Nursing and Health Sciences — Fri, 03 Feb 2012 05:00:00 +0100

This study assessed a targeted continuing osteoporosis educational program and investigated awareness and prevention of osteoporosis in Chinese female pre‐internship nurse students. A quasi‐experimental study was conducted. The program was presented to 256 nurse students. The baseline knowledge score of the nurse students was low (9.78 ± 3.13). They had inadequate osteoporosis health beliefs, self‐efficacy and related behaviors. The educational program significantly augmented osteoporosis knowledge (Student's paired t = −13.42, P < 0.001), total osteoporosis health beliefs (Student's paired t = −4.46, P < 0.001), and the subscale (P < 0.001) except for the perceived barriers to exercising and calcium intake. Participants showed a significant incr...

Electronic medical records have low impact on quality of osteoporosis care

MedWire News - Bone Health — Fri, 03 Feb 2012 04:48:08 +0100

The use of electronic medical records only marginally improves the care of patients with osteoporosis, a US pilot study has found. (Source: MedWire News - Bone Health)

Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:01 +0100

CONCLUSION: We have found that the presence of anemia was as an independent predictor of LBM for spine after adjusting for body mass index and other confounders in postmenopausal Turkish women. PMID: 22284246 [PubMed - in process] (Source: European Journal of Internal Medicine)

Prevalence of thoracic vertebral fractures in Spanish patients hospitalized in Internal Medicine Departments. Assessment of the clinical inertia. (PREFRAMI study).

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:33 +0100

CONCLUSIONS: A high prevalence of asymptomatic VF is verified in medical inpatients ≥50years of age. The FRAX index did not turn out to be predictive of the presence of VF in this population. There is an underdiagnosis of osteoporotic VF in the coding at hospital discharge. Action protocols are necessary to avoid clinical inactivity regarding this entity. PMID: 22284255 [PubMed - in process] (Source: European Journal of Internal Medicine)

Osteocyte regulation of bone mineral: a little give and take

Osteoporosis International — Thu, 02 Feb 2012 18:14:38 +0100

Abstract Osteocytes actively participate in almost every phase of mineral handling by bone. They regulate the mineralisation of osteoid during bone formation, and they are also a major RANKL-producing cell. Osteocytes are thus able to liberate bone mineral by regulating osteoclast differentiation and activity in response to a range of stimuli, including bone matrix damage, bone disuse and mechanical unloading, oestrogen deficiency, high-dose glucocorticoid and chemotherapeutic agents. At least some of these activities may be regulated by the osteocyte-secreted product, sclerostin. There is also mounting evidence that in addition to regulating phosphate homeostasis systemically, osteocytes contribute directly to calcium homeostasis in the mature skeleton. Osteocyte cell dea...

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Prevalence of vertebral fracture in oldest old nursing home residents

Osteoporosis International — Thu, 02 Feb 2012 18:14:36 +0100

Conclusion In oldest old nursing home residents, osteoporosis and vertebral fracture were frequently detected. Ten-year fracture probability appeared to be mainly determined by age and clinical risk factors obtained by medical history, rather than by BMD or vertebral fracture. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00198-012-1900-6Authors A. Rodondi, Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, CH–1211 Geneva 14, SwitzerlandT. Chevalley, Division of Bone Diseases, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, CH–1211 Geneva 14, SwitzerlandR. Rizzoli, Division of Bone Diseases, Department of Medical Specialties, Genev...

Osteoporosis Drug Complications Linked To Genetic Factors

Health News from Medical News Today — Thu, 02 Feb 2012 18:00:00 +0100

According to a study published in the online version of the journal The Oncologist, a genetic variation that increases the risk of individuals who take bisphosphonates, developing serious necrotic jaw bone lesions, has been identified by researchers at the Columbia University College of Dental Medicine. Bisphosphonates are a common class of osteoclastic inhibitors that work by attaching to calcium in the bone and inhibiting osteoclasts, bone cells that disintegrate the bone's mineral structure... (Source: Health News from Medical News Today)

Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study

European Journal of Nutrition — Thu, 02 Feb 2012 17:57:46 +0100

Conclusions The GBB may help to prevent osteoporosis and reduce fracture risk, at least at the hip, in postmenopausal women. Larger and longer-term clinical trials are warranted. Content Type Journal ArticleCategory Original ContributionPages 1-13DOI 10.1007/s00394-012-0304-xAuthors Joan Lappe, Osteoporosis Research Center, Creighton University Medical Center, 601 North 30th Street, Suite 4820, Omaha, NE 68131, USAIris Kunz, DSM Nutritional Products, R&D Human Nutrition and Health, Kaiseraugst, SwitzerlandIgor Bendik, DSM Nutritional Products, R&D Human Nutrition and Health, Kaiseraugst, SwitzerlandKevin Prudence, DSM Nutritional Products, R&D Human Nutrition and Health, Kaiseraugst, SwitzerlandPeter Weber, DSM Nutritional Products, R&D Human Nutrition and Health, Ka...

Sequential multiple insufficiency fractures around knee over 6 months in a patient with primary osteoporosis

European Journal of Orthopaedic Surgery and Traumatology — Thu, 02 Feb 2012 17:57:26 +0100

In this report, we describe a case of multiple insufficiency fractures occurring over 6 months in the bilateral knees of an individual with primary osteoporosis. An 87-year-old woman complained of spontaneous pain in her right knee. A plain X-ray did not show any lesions at the time; however, 2 weeks later, a slightly displaced supracondylar fracture was observed. The fracture was treated with a long leg cast for 6 weeks. The patient was able to walk with a walker 12 weeks after the injury, but her right thigh muscles had atrophied. Four months after the first injury, she suffered left knee pain. Magnetic resonance imaging (MRI) showed an undisplaced supracondylar fracture of the left femur. After undergoing the same treatment as for the previous fracture for 8 we...

The use of intravenous bisphosphonate therapy to treat vertebral fractures due to osteoporosis among boys with Duchenne muscular dystrophy

Osteoporosis International — Thu, 02 Feb 2012 06:55:23 +0100

Conclusions Intravenous bisphosphonate therapy was associated with improvements in back pain and stabilization to improvement in vertebral height ratios of previously fractured vertebral bodies. At the same time, such therapy does not appear to completely prevent the development of new vertebral fractures in this context. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00198-012-1911-3Authors A. M. Sbrocchi, Division of Endocrinology, Children’s Hospital of Eastern Ontario, 401 Smyth Rd., Ottawa, ON, Canada K1H 8L1F. Rauch, Genetics Unit, Shriners Hospital for Children, Montreal, QC, CanadaP. Jacob, Division of Neurology, Children’s Hospital of Eastern Ontario, Ottawa, ON, CanadaA. McCormick, Division of Neurology, Children’s Hospita...

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Heart failure linked to thinner bones and fractures

EurekAlert! - Medicine and Health — Thu, 02 Feb 2012 05:00:00 +0100

(The Endocrine Society) Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (Source: EurekAlert! - Medicine and Health)

Southampton research shows early bone growth linked to bone density in later life

EurekAlert! - Social and Behavioral Science — Thu, 02 Feb 2012 05:00:00 +0100

(University of Southampton) Researchers from the University of Southampton, in collaboration with a research group in Delhi, India, have shown that growth in early childhood can affect bone density in adult life, which could lead to an increased risk of developing bone diseases like osteoporosis. (Source: EurekAlert! - Social and Behavioral Science)

Delay from fracture to hospital admission: a new risk factor for hip fracture mortality?

Osteoporosis International — Wed, 01 Feb 2012 17:14:09 +0100

Conclusions If the association estimated in our study is causal, our results provide evidence that some hip fracture-related deaths could be prevented by improved patient access to appropriate and timely hospital care in the context of a developing country. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00198-012-1917-xAuthors E. I. O. Vidal, Internal Medicine Department, Universidade Estadual Paulista (UNESP), Botucatu, BrazilD. C. Moreira-Filho, Preventive and Social Medicine Department, Universidade Estadual de Campinas (UNICAMP), Campinas, BrazilR. S. Pinheiro, Public Health Studies Institute, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, BrazilR. C. Souza, Health Sciences Center, Fundação Serra dos Órgãos, Teresop...

Bone mineral density by DXA and HR pQCT can discriminate fracture status in men and women with stages 3 to 5 chronic kidney disease

Osteoporosis International — Wed, 01 Feb 2012 17:14:09 +0100

Conclusions Among CKD patients not yet requiring renal replacement therapy, BMD by DXA is able to discriminate fracture status. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00198-012-1908-yAuthors S. A. Jamal, Women’s College Research Institute, 790 Bay Street, Suite 725, Toronto, ON M5G 1N8, CanadaA. M. Cheung, Department of Medicine, University of Toronto, Toronto, ON, CanadaS. L. West, Women’s College Research Institute, 790 Bay Street, Toronto, ON M5G 1N8, CanadaC. E. Lok, Department of Medicine, University of Toronto, Toronto, ON, Canada Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)

Soft Tissue Composition and the Risk of Low Bone Mineral Density: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-3), 2009

Calcified Tissue International — Wed, 01 Feb 2012 17:12:58 +0100

In conclusion, higher LM was associated with a lower risk of low BMD in both genders, while higher FM was associated with a higher risk of low BMD for men <50 years but not for women and men ≥50 years. The combined effects of LM and FM on BMD were gender- and menopause status–specific. Content Type Journal ArticleCategory Original ResearchPages 1-7DOI 10.1007/s00223-012-9573-xAuthors Kayoung Lee, Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, 633-165 Kaegum-dong, Busan Jin-Gu, Busan, 614-735 South Korea Journal Calcified Tissue InternationalOnline ISSN 1432-0827Print ISSN 0171-967X (Source: Calcified Tissue International)

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The elderly inflammatory bowel disease patient and osteoporosis

Future Medicine: Aging Health — Wed, 01 Feb 2012 14:53:42 +0100

Aging Health , February 2012, Vol. 8, No. 1, Pages 31-42. (Source: Future Medicine: Aging Health)

Osteoporosis/Osteopenia and hemophilic arthropathy in severe hemophilic patients.

Archives of Iranian Medicine — Wed, 01 Feb 2012 05:00:00 +0100

CONCLUSION: Our results suggest that men with severe hemophilia have reduced BMD. Patients at risk are those with signs of hemophilic arthropathy. Because osteoporosis may complicate the future treatment of patients with hemophilia, screening of patients with hemophilic arthropathy for reduction of BMD and preventive therapies is highly recommended. PMID: 22292576 [PubMed - in process] (Source: Archives of Iranian Medicine)

Sleep duration pattern and chronic diseases in Brazilian adults (ISACAMP, 2008/09)

Sleep Medicine — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: Socio-demographic factors and health diseases were associated to sleep duration. This issue should be considered in health promotion strategies. (Source: Sleep Medicine)

Determinants of Fracture Risk in Older WomenDeterminants of Fracture Risk in Older Women

Medscape Today Headlines — Wed, 01 Feb 2012 04:00:00 +0100

This study looked at risk factors for fractures in older women, comparing risk factors for osteoporosis with those related to falls and mobility. Which carried more weight? Age and Ageing (Source: Medscape Today Headlines)

Letter to the Editor: Regarding “The Utility and Limitations of FRAX: A US Perspective”

Current Osteoporosis Reports — Tue, 31 Jan 2012 16:46:08 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s11914-012-0095-2Authors Edward Czerwinski, Department of Bone and Joint Diseases, Medical College Jagiellonian University, ul. Kopernika 32, 31-501 Krakow, Poland Journal Current Osteoporosis ReportsOnline ISSN 1544-2241Print ISSN 1544-1873 (Source: Current Osteoporosis Reports)

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Poor bone microarchitecture in older men with impaired physical performance—the STRAMBO study

Osteoporosis International — Tue, 31 Jan 2012 07:05:11 +0100

Conclusion In older men, poor physical performance is associated with lower hip aBMD and poor bone microarchitecture (mainly at the distal tibia). Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s00198-012-1906-0Authors S. Blaizot, INSERM UMR 1033, Université de Lyon, Lyon, FranceS. Boutroy, INSERM UMR 1033, Université de Lyon, Lyon, FranceN. Vilayphiou, INSERM UMR 1033, Université de Lyon, Lyon, FranceS. Boonen, Division of Gerontology and Geriatrics and Center for Musculoskeletal Research, Division of Geriatric Medicine and Center for Metabolic Bone Diseases, Leuven University Hospital Department of Internal Medicine, Leuven, BelgiumR. Chapurlat, INSERM UMR 1033, Université de Lyon, Lyon, FranceP. Szulc, INSERM UMR 1033, Université d...

Frailty and sarcopenia: definitions and outcome parameters

Osteoporosis International — Tue, 31 Jan 2012 07:05:09 +0100

Abstract An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatme...

Comment on Compston: Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw

Osteoporosis International — Tue, 31 Jan 2012 07:05:08 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00198-012-1905-1Authors K. Michaëlsson, Department of Surgical Sciences, Uppsala University, SE 751 85 Uppsala, SwedenJ. Schilcher, Department of Experimental and Clinical Medicine, Faculty of Health Science, Linköping University, SE 581 85 Linköping, SwedenP. Aspenberg, Department of Experimental and Clinical Medicine, Faculty of Health Science, Linköping University, SE 581 85 Linköping, Sweden Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)

Osteoblastogenesis regulation signals in bone remodeling

Osteoporosis International — Tue, 31 Jan 2012 07:05:08 +0100

Abstract Bone remodeling is essential for adult bone homeostasis. The failure of this process often leads to the development of osteoporosis, a present major global health concern. The most important factor that affects normal bone remodeling is the tightly controlled and orchestrated regulation of osteoblasts and osteoclasts. The present review summarized the recent discoveries related to osteoblast regulation from several signals, including transforming growth factor-β, bone morphogenetic proteins, Wnt signal, Notch, Eph–Ephrin interaction, parathyroid hormone/parathyroid hormone-related peptide, and the leptin–serotonin–sympathetic nervous systemic pathway. The awareness of these mechanisms will facilitate further research that explores bone remodeling and osteop...

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

Arthritis and Rheumatism — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion:The mechanism by which stromal cell expression of 11β‐HSD1 is regulated is novel and distinct from that in other tissues. These findings open up new opportunities to inhibit or stimulate local glucocorticoid levels in cells of mesenchymal stromal lineage during inflammation. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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Disorders of bone metabolism

Surgery (Medicine Publishing) — Mon, 30 Jan 2012 14:21:38 +0100

This article focusses on the changes in bone remodelling which underlie both the development and treatment of osteoporosis. Osteomalacia, as an example of a mineralization disorder and Paget’s disease as an example of a focal disorder of bone remodelling, are also briefly reviewed. (Source: Surgery (Medicine Publishing))

Genetic Variation Revealed That Raises A Risk Linked To Bisphosphonates

Health News from Medical News Today — Mon, 30 Jan 2012 08:00:00 +0100

Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. The discovery paves the way for a genetic screening test to determine who can safely take these drugs. The study appears in the online version of the journal The Oncologist. Oral bisphosphonates are currently taken by some 3 million women in the United States for the prevention or treatment of osteoporosis... (Source: Health News from Medical News Today)

Comparison of mandibular bone mineral density in osteoporotic, osteopenic and normal elderly edentulous subjects measured by the dual‐energy X‐ray absorptiometry technique

Gerodontology — Mon, 30 Jan 2012 05:00:00 +0100

Conclusion: Classification of edentulous mandibles according to low and high bone mineral densities is a problem in implant dentistry. The results of this study demonstrated that femoral bone mineral density status may be used to provide preliminary information about the bone mineral density of the mandibular body region in elderly edentulous subjects. (Source: Gerodontology)

Androgen deprivation therapy-associated vasomotor symptoms.

Asian Journal of Andrology — Mon, 30 Jan 2012 05:00:00 +0100

This article reviews current options for the treatment of hot flashes in patients taking ADT.Asian Journal of Andrology advance online publication, 30 January 2012; doi:10.1038/aja.2011.101. PMID: 22286861 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)

Complications of pamidronate therapy in paediatric osteoporosis

Journal of Children's Orthopaedics — Sat, 28 Jan 2012 16:52:25 +0100

This study aims to assess the early minor and major medical and late surgical complications and the effect of the dose and regimen of infusion on these events in paediatric osteoporosis. Study design Retrospective cohort. Materials and methods Three regimens for pamidronate infusion were followed in sequential periods in 10 years. Regimen A delivered 1.5 mg/kg/day as a single dose once in 3 months. Regimen B delivered 2 mg/kg/day for 3 days twice a year, while regimen C delivered 1 mg/kg/day for 3 days every 3–4 months. Adverse events were classified as early (major and minor) or late (surgical). Results Forty-eight children received 158 infusions using one of the three regimens. Twenty-n...

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Can PET-CT Imaging and Radiokinetic Analyses Provide Useful Clinical Information on Atypical Femoral Shaft Fracture in Osteoporotic Patients?

Current Osteoporosis Reports — Sat, 28 Jan 2012 16:50:58 +0100

Abstract Atypical femoral shaft fractures are associated with the extended usage of nitrogen-containing bisphosphonates as therapy for osteoporosis. For such fractures, the positron emission tomography (PET) procedure, coupled with computerized tomography (CT), provides a potential imaging modality for defining aspects of the pathogenesis, site specificity, and possible prodromal abnormalities prior to fracture. PET-CT may assess the radiokinetic variables K1 (a putative marker for skeletal blood flow) and Ki (a putative marker for skeletal bone formation), and when combined with PET imaging modalities and CT skeletal site localization, may define the site of such radiokinetic findings. Further studies into the clinical usage of PET-CT in patients with atypical femoral sha...

Genetic variation that raises risk of serious complication linked to osteoporosis drugs identified

ScienceDaily Headlines — Fri, 27 Jan 2012 18:58:58 +0100

Researchers have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. (Source: ScienceDaily Headlines)

Novel nano-materials, RGD-tetrapeptide-modified 17[small beta]-amino-11[small alpha]-hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation

RSC - J. Mater. Chem. latest articles — Fri, 27 Jan 2012 18:02:50 +0100

J. Mater. Chem., 2012, Advance ArticleDOI: 10.1039/C2JM13983A, PaperYuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Shiqi PengHigh anti-osteoporosis activity, low side effects and nano-images of three novel 17[small beta]-(RGD-peptidyl-amido)-11[small alpha]-hydroxyandrost-1,4-diene-3-ones are disclosed for the first time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)

Calcium supplementation, renin, and vascular risk

Osteoporosis International — Fri, 27 Jan 2012 17:56:37 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00198-012-1910-4Authors M. F. McCarty, NutriGuard Research, Inc., Encinitas, CA 92024, USA Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)

Clinical Use of Bone Turnover Markers to Monitor Pharmacologic Fracture Prevention Therapy

Current Osteoporosis Reports — Fri, 27 Jan 2012 17:54:46 +0100

Abstract Monitoring of drug therapies to prevent fractures is controversial. Measurement of bone turnover markers has the potential to identify those with a suboptimal response to fracture prevention medication within a few months of its commencement. However, given the imprecision of currently commercially available assays of bone turnover markers, many individual persons who are “suboptimal medication responders” are likely to be misclassified as “adequate responders” or vice versa, depending on the cut point chosen to define suboptimal and adequate response. Before bone turnover markers can be recommended for routine use in clinical practice to monitor fracture prevention therapies, three advances are needed: 1) bone marker assays with better precision; 2) resea...

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Postmenopausal osteoporosis screening: which test is best?

PharmacoEconomics and Outcomes News — Fri, 27 Jan 2012 15:13:30 +0100

(Source: PharmacoEconomics and Outcomes News)

Position Statement On The Role Of Vitamin D In Postmenopausal Women Published In Maturitas

Health News from Medical News Today — Fri, 27 Jan 2012 08:00:00 +0100

Elsevier, a world-leading provider of scientific, technical and medical information products and services, has announced the publication of a position statement by the European Menopause and Andropause Society (EMAS) in journal Maturitas on the role of vitamin D in postmenopausal women with summary recommendations. Vitamin D deficiency is common and may affect up to 70% of Europeans. It is classified as a public health issue as it can contribute to many diseases, especially osteoporosis... (Source: Health News from Medical News Today)

Hormonal and dietary influences on true fractional calcium absorption in women: role of obesity

Osteoporosis International — Fri, 27 Jan 2012 06:51:47 +0100

Conclusion Together, these data show that dietary fat is the most significant positive predictor of TFCA which may have implications for dietary intake for non-obese individuals who are more likely to have lower and potentially compromised Ca absorption. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00198-012-1901-5Authors S. A. Shapses, Department of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ 08901-8525, USAD. Sukumar, Department of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ 08901-8525, USAS. H. Schneider, Department of Endocrinology and Metabolism, University of Medicine and Dentistry at New Jersey, New Brunswick, NJ 08901, USAY. Schlussel, Department of Nutritional Sci...

US Drug Watchdog Expands Its Initiative To Identify Women Who Used The...

PRWeb: Medical Pharmaceuticals — Fri, 27 Jan 2012 06:33:34 +0100

The US Drug Watchdog says, "Its hard to comprehend what it might be like for a middle aged, or older woman, who was taking the Osteoporosis drug called Fosamax, who had an unexplainable broken...(PRWeb January 25, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9123929.htm (Source: PRWeb: Medical Pharmaceuticals)

Oral Calcitonin

Current Osteoporosis Reports — Thu, 26 Jan 2012 16:46:17 +0100

Abstract Both injectable and nasal spray calcitonins have been utilized in the treatment of postmenopausal osteoporosis for over 25 years. More widespread use of calcitonin in the treatment of osteoporosis has been hampered in part due to poor patient acceptability and compliance and the inability of patients to take this medication as an oral pill. In recent years, an oral preparation of calcitonin has been developed that combines the active peptide hormone with a caprylic acid derivative to enhance bioavailability. Clinical trials with oral calcitonin in patients with osteoarthritis are currently being conducted. A recent phase 3 study failed to demonstrate significant vertebral fracture reduction, and as a result the clinical program for oral calcitonin in osteopor...

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Knowledge of orthopaedic surgeons in managing patients with fragility fracture

International Orthopaedics — Thu, 26 Jan 2012 16:45:31 +0100

Conclusions The majority of orthopaedic surgeons questioned lacked knowledge of fragility fracture management. This is reflected by limited knowledge of osteoporosis assessment and treatment in most areas. An appropriate method should be created to manage patients with fragility fractures to guarantee the patient the best possible care. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s00264-012-1482-0Authors Reza Sorbi, Students’ Scientific Research Center (SSRC), Exceptional Talent Development Center (ETDC), Tehran University of Medical Sciences (TUMS), Tehran, IranMohamad Reza Aghamirsalim, Students’ Scientific Research Center (SSRC), Exceptional Talent Development Center (ETDC), Tehran University of Medical Sciences (TUMS), Tehran, Ira...

Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk

Osteoporosis International — Thu, 26 Jan 2012 16:44:57 +0100

Conclusions Daily consumption of milk containing 250 mg calcium over 18 months prevents BMD loss at the hip and the femoral neck in postmenopausal Chinese women. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00198-012-1895-zAuthors J.-C. Gui, Department of Nuclear Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040 People’s Republic of ChinaJ. R. Brašić, Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USAX.-D. Liu, Department of Nuclear Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040 People’s Republic of ChinaG.-Y. Gong, Technical Center,...

Magnolol Protects Osteoblastic MC3T3-E1 Cells Against Antimycin A-Induced Cytotoxicity Through Activation of Mitochondrial Function

Inflammation — Thu, 26 Jan 2012 16:44:49 +0100

Abstract Antimycin A treatment of cells blocks the mitochondrial electron transport chain and leads to elevated ROS generation. In the present study, we investigated the protective effects of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells. Osteoblastic MC3T3-E1 cells were pre-incubated with magnolol before treatment with antimycin A. Cell viability and mineralization of osteoblasts were assessed by MTT assay and Alizarin Red staining, respectively. Mitochondrial dysfunction in cells was measured by mitochondrial membrane potential (MMP), complex IV activity, and ATP level. The cellular antioxidant effect of magnolol in osteoblastic MC3T3-E1 cells was assessed by measuring cardioli...

Nephrotic syndrome after oral bisphosphonate (alendronate) administration in a patient with osteoporosis

Osteoporosis International — Wed, 25 Jan 2012 18:07:44 +0100

Abstract Alendronate is a widely used bisphosphonate in the treatment of osteoporosis. Although it has been proven to be a very useful drug, it has some side effects as well. In this paper, we describe a case of nephrotic syndrome due to alendronate administration. A 36-year-old man was admitted to the nephrology outpatient clinic with widespread edema 4 months after initiation of alendronate. He had a 13-kg weight gain within a 2-week period. He had no clinical or laboratory problems apart from osteoporosis, which was the indication for initiation of the drug. Physical examination at admission was unremarkable, but for nephrotic edema. Laboratory studies revealed nephrotic range proteinuria (13.5 g/day), normal renal function, hypoalbuminemia (1.7 g/dl), and...

Assessment of Fracture Risk

Current Osteoporosis Reports — Wed, 25 Jan 2012 06:52:38 +0100

Abstract Osteoporosis-related fractures (low-trauma, fragility fractures) are associated with significant morbidity, mortality, and health care expenditure worldwide. In the absence of a defining fracture, the diagnosis of osteoporosis is based on the World Health Organization’s T-score criteria using central dual-energy x-ray absorptiometry (DXA). Paradoxically, the majority of those patients who will sustain a low-trauma fracture do not meet the T-score definition of osteoporosis. Conversely, younger individuals with bone density in the osteoporotic range but no other risk factors have relatively low fracture rates and yet are frequently considered candidates for osteoporosis therapies. The limited accuracy of bone density testing alone to predict fractures has led to ...

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Reserve your place at the largest bone event in Europe

EurekAlert! - Medicine and Health — Wed, 25 Jan 2012 05:00:00 +0100

(International Osteoporosis Foundation) Join the International Osteoporosis Foundation and the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis at the European Congress on Osteoporosis & Osteoarthritis and the 2nd IOF-ESCEO Pre-Clinical Symposium. The Congress is to be held in Bordeaux, France, March 21-24, 2012. (Source: EurekAlert! - Medicine and Health)

Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures

European Journal of Human Genetics — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Niklas R Jørgensen, Lise B Husted, Kristen K Skarratt, Leanne Stokes, Charlotte L Tofteng, Torben Kvist, Jens-Erik B Jensen, Pia Eiken, Kim Brixen, Stephen Fuller, Rory Clifton-Bligh, Alison Gartland, Peter Schwarz, Bente L Langdahl & James S Wiley (Source: European Journal of Human Genetics)

Patients and partners lack knowledge of androgen deprivation therapy side effects.

Urologic Oncology — Wed, 25 Jan 2012 05:00:00 +0100

CONCLUSION: The lack of awareness of ADT side effects may partially explain why ADT currently results in significant decreases in the quality of life of patients and their partners. Patients uninformed about side effects do not engage in behaviors to prevent or reduce the risk of adverse effects. Improved efforts to educate patients about treatment side effects and coping strategies may result in improved psychosocial and physical health for CaP patients undergoing ADT. PMID: 22285008 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Development of an electronic medical record based intervention to improve medical care of osteoporosis

Osteoporosis International — Tue, 24 Jan 2012 18:09:41 +0100

Conclusion An electronic medical record intervention without electronic reminders created with physician input achieves an increase in calcium supplementation but fails to increase diagnosis or treatment for osteoporosis at the time of hospitalization for a fragility fracture. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00198-011-1866-9Authors B. J. Edwards, Bone Health and Osteoporosis Center, Medicine, Feinberg School of Medicine, Northwestern University, 645 North Michigan, Suite 630, Chicago, IL 60611, USAA. D. Bunta, Bone Health and Osteoporosis Center, Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAJ. Anderson, Northwestern Memorial Hospital, Chicago, IL, USAA. Bobb, Nort...

Too many tests? Routine checks getting second look

CTV Health — Tue, 24 Jan 2012 13:30:35 +0100

Recent headlines offered a fresh example of how the health-care system subjects people to too many medical tests -- this time research showing millions of older women don't need their bones checked for osteoporosis nearly so often. (Source: CTV Health)

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Health Tip: Exercise for Healthier Bones

MedlinePlus Health News — Tue, 24 Jan 2012 12:00:00 +0100

Activities that can help maintain bone healthSource: HealthDay Related MedlinePlus Pages: Exercise and Physical Fitness, Osteoarthritis, Osteoporosis (Source: MedlinePlus Health News)

Key to aging well? Keep your bones strong

USATODAY.com Health — Tue, 24 Jan 2012 11:00:00 +0100

Osteoporosis causes the bones to become brittle and afflicts about 44 million Americans. Half of women will break a bone because of it. (Source: USATODAY.com Health)

Femoral Neck Bone Strength Estimated by Hip Structural Analysis (HSA) in Swedish Caucasians Aged 6–90 Years

Calcified Tissue International — Tue, 24 Jan 2012 07:54:00 +0100

Abstract Dual-energy X-ray absorptiometry hip scans of 1,760 population-based Caucasians, 599 girls and 642 boys aged 6–19 years and 270 women and 249 men aged 20–90 years, were analyzed with the hip structural analysis (HSA) software to present age- and sex-specific normative HSA data of the femoral neck (FN). Measured traits included bone mineral density (BMD), cross-sectional area (CSA), section modulus (Z), periosteal diameter (PD), endosteal diameter (ED), cortical thickness (CT), and cross-sectional moment of inertia (CSMI). When plotting the measured traits versus age, the curves increased with higher ages until statistically significant break points were reached, for all traits at age 17 in girls and age 19 in boys. After the break points, PD and ED i...

What is the importance of “halo” phenomenon around bone cement following vertebral augmentation for osteoporotic compression fracture?

Osteoporosis International — Tue, 24 Jan 2012 07:26:51 +0100

Conclusions The peri-cement halo was found to be associated with vertebral recollapse, this sign likely represents a poor prognostic factor after vertebral augmentation for osteoporotic compression fractures. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00198-012-1896-yAuthors K. H. Kim, Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eongu-ro, Gangnam-gu, Seoul, 135-720 KoreaS. U. Kuh, Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eongu-ro, Gangnam-gu, Seoul, 135-720 KoreaJ. Y. Park, Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Hospital...

Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women

Osteoporosis International — Tue, 24 Jan 2012 07:26:51 +0100

Conclusions This study does not support a significant role for PUFA intake in the prevention of hip fractures, although low total PUFA, n-6 PUFA, or linoleic acid intakes may increase the risk in women. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00198-012-1903-3Authors J. K. Virtanen, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211 Kuopio, FinlandD. Mozaffarian, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USAW. C. Willett, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USAD. Feskanich, Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Ha...

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A population-based 2-year follow-up study on the relationship between bisphosphonates and the risk of stroke

Osteoporosis International — Tue, 24 Jan 2012 07:26:50 +0100

Conclusion Patients who received bisphosphonate therapy were associated with a lower risk of stroke during a 2-year follow-up period. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00198-012-1894-0Authors J.-H. Kang, Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanJ. J. Keller, School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, TaiwanH.-C. Lin, School of Health Care Administration, College of Medicine, Taipei Medical University, 250 Wu-Hsing St, Taipei, 110 Taiwan Journal Osteoporosis InternationalOnline ISSN 1433-2965Print ISSN 0937-941X (Source: Osteoporosis International)

Guidance for the prevention of bone loss and fractures in postmenopausal women treated with aromatase inhibitors for breast cancer: an ESCEO position paper

Osteoporosis International — Tue, 24 Jan 2012 07:26:50 +0100

Conclusion The ESCEO working group recommends that all AI-treated women should be evaluated for fracture risk. Besides general recommendations, zoledronic acid 4 mg i.v. every 6 months, denosumab s.c., or possibly oral bisphosphonates should be administered for the entire period of AI treatment to all osteoporotic women (T-score hip/spine <−2.5 or ≥1 prevalent fragility fracture), to women aged ≥75 irrespective of BMD, and to patients with T-score <−1.5 + ≥1 clinical risk factor or T-score <−1.0 + ≥2 clinical risk factors. Alternatively, therapy could be considered in patients with a FRAX-determined 10-year hip fracture probability ≥3%. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00198-011-1...

Examining the Link Between Bariatric Surgery, Bone Loss, and Osteoporosis: a Review of Bone Density Studies

Obesity Surgery — Tue, 24 Jan 2012 06:50:11 +0100

Abstract As the popularity of bariatric surgery to treat morbid obesity has risen, so has a concern of increased skeletal fragility secondary to accelerated bone loss following bariatric procedures. We reviewed cross-sectional and prospective literature reporting bone density outcomes following bariatric surgical treatment for morbid obesity. Prospective research provides evidence of hip and lumbar spine areal bone mineral density (aBMD) reductions primarily in women despite calcium and vitamin D supplementation. Femoral neck aBMD declines of 9–11% and lumbar spine aBMD reductions up to 8% were observed at the first post-operative year following malabsorptive procedures. Mean T- and Z-scores up to 25 years following surgery remained within normal and healthy ranges. ...

Calcium controversy explained - Vitamin K2 keeps calcium in your bones and out of your arteries

NaturalNews.com — Tue, 24 Jan 2012 06:00:00 +0100

Popping calcium pills has become the norm in our culture where osteoporosis has become pervasive, but in recent years research points to calcium supplements posing a danger to our heart health. We're left to wonder: is calcium beneficial or dangerous? There is little... (Source: NaturalNews.com)

Dual Specificity Phosphatase 1 null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

Arthritis and Rheumatism — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions:DUSP1 is a critical regulator of osteoclast activity, and limits bone destruction in an experimental model of rheumatoid arthritis. Defects in the expression or activity of DUSP1 in humans may correlate with propensity to develop osteolytic lesions in arthritis. (Source: Arthritis and Rheumatism)

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Vitamin D and fertility-a systematic review.

European Journal of Endocrinology — Tue, 24 Jan 2012 05:00:00 +0100

Discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. VDR knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including in-vitro fertilization (IVF) outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) ...

Risk factors for male osteoporosis identified

MedWire News - Bone Health — Tue, 24 Jan 2012 04:40:03 +0100

Several well-established risk factors for osteoporosis in women do not predict osteoporotic fracture in men, a study of male veterans has found. (Source: MedWire News - Bone Health)

Health Board

The Irish Times - Health — Tue, 24 Jan 2012 00:19:25 +0100

Osteoporosis and arthritis of the knee will be discussed at a free public talk tonight at 7pm in the Sports Surgery Clinic, Santry Demesne, Dublin 9. Speakers include Michelle O’Brien, from the Irish Osteoporosis Society, and Niall Hogan, orthopaedic consultant. More details on tel: 01-5262168 or email: fionaroche@sportssurgeryclinic.com (Source: The Irish Times - Health)

Atypical subtrochanteric femoral fracture.

Physical Therapy — Mon, 23 Jan 2012 15:30:06 +0100

Authors: Park SY, Lee SH, Han SB Abstract The patient was a 72-year-old woman who presented to an emergency department with a chief complaint of severe right thigh pain following a fall. Prior to the fall, the patient reported an 8-month history of worsening right thigh pain. The patient had a 4-year history of alendronate and calcium use to manage her osteoporosis. Dual X-ray absorptiometry (DXA) hip images taken 1 month prior to the patient's fracture demonstrated lateral cortical thickening in the subtrochanteric region of the femur. In retrospect, this finding was concerning for impending complete fracture. J Orthop Sports Phys Ther 2012;42(1):44. doi:10.2519/jospt.2012.0402. PMID: 22236717 [PubMed - in process] (Source: Physical Therapy)

Calcium supplements may increase the risk of cardiovascular events in postmenopausal women

Evidence-Based Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Context Calcium supplementation is widely used for osteoporosis (OP) prevention and treatment. Many women buy calcium supplements, ±vitamin D. The authors' earlier randomised controlled trial (RCT) and meta-analysis suggests that calcium supplementation increases cardiovascular-event risks provoked controversy, as has this report.1–3 Methods The ‘Women’s Health Initiative Calcium/vitamin D Supplementation Study' (WHICaD) limited access data set of 36 282 community-dwelling postmenopausal women comparing calcium plus vitamin D with placebo over 7 years was re-examined for effects of personal (preprotocol) calcium usage, adjusted for other cardiovascular disease (CVD) risk factors, followed by meta-analysis of the data on non-personal calcium users and from eight sim...

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Laparoscopic antireflux surgery and esomeprazole similarly efficacious for symptoms in people with gastro-oesophageal reflux disease who respond well to proton pump inhibitors

Evidence-Based Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Context Gastro-oesophageal reflux disease (GERD) is a chronic, relapsing condition – manifesting mostly with heartburn and acid regurgitation – that negatively affects daily quality of life. The two main treatments for GERD are medical – proton pump inhibitors (PPIs) and laparoscopic antireflux surgery (LARS). Both treatments have advantages and side effects that continue to be debated. On one hand, medical therapy may be associated with residual regurgitation and the potential long-term side effects of PPI (eg, osteoporotic fractures, drug–drug interaction). On the other hand, LARS may be associated with technical failures, dysphagia and bloating. Methods Under the acronym LOTUS, this 5-year randomised study compared efficacy and safety of LARS with ‘optimise...

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors.

Acta Pharmacologica Sinica — Mon, 23 Jan 2012 05:00:00 +0100

Authors: Pal K, Melcher K, Xu HE Abstract Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a wide spectrum of physiological activities, from metabolic regulation and stress control to development and maintenance of the skeletal system. As such, they are important drug targets for the treatment of diabetes, osteoporosis, and stress related disorders. Class B GPCRs are organized into two modular domains: an extracellular domain (ECD) and a helical bundle that contains seven transmembrane helices (TM domain). The ECD is responsible for the high affinity and specificity of hormone binding, and the TM domain is required for receptor activation and signal coupling to ...

Too Many Tests? Routine Checks Getting Second Look

RWJF News Digest - Quality/Equality — Mon, 23 Jan 2012 05:00:00 +0100

Recent headlines offered a fresh example of how the health care system subjects people to too many medical tests — this time research showing millions of older women don't need their bones checked for osteoporosis nearly so often. (Source: RWJF News Digest - Quality/Equality)

From parathyroid hormone to cytosolic Ca2+ signals.

Biochemical Society Transactions — Sun, 22 Jan 2012 22:28:35 +0100

Authors: Taylor CW, Tovey SC Abstract PTHR1 (type 1 parathyroid hormone receptors) mediate the effects of PTH (parathyroid hormone) on bone remodelling and plasma Ca2+ homoeostasis. PTH, via PTHR1, can stimulate both AC (adenylate cyclase) and increases in [Ca2+]i (cytosolic free Ca2+ concentration), although the relationship between the two responses differs between cell types. In the present paper, we review briefly the mechanisms that influence coupling of PTHR1 to different intracellular signalling proteins, including the G-proteins that stimulate AC or PLC (phospholipase C). Stimulus intensity, the ability of different PTH analogues to stabilize different receptor conformations ('stimulus trafficking'), and association of PTHR1 with scaffold proteins, notably NHERF1 and NHERF2...

Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta‐analysis of randomised controlled trials

International Journal of Clinical Practice — Sat, 21 Jan 2012 13:59:55 +0100

SummaryTo determine the efficacy of teriparatide supplementation for improving bone mineral density (BMD) and fracture risk in postmenopausal osteoporosis and if effects vary with factors. We identified eight randomised controlled trials (n = 2388) using electronic databases, supplemented by a hand‐search of the reference lists. All trials aimed to evaluate the efficacy of daily subcutaneous teriparatide injection in postmenopausal osteoporosis. The main outcomes were fracture risk and percentage change of BMD from baseline. Data were pooled by employing a random‐effect model. In trials that reported BMD as an outcome, treatment was associated with an increase of bone mass of 8.14% [95% confidence interval (CI): 6.72–9.55%; eight trials, n = 2206] in spine and 2.48% (95% CI: ...

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US Drug Watchdog Calls Its Osteoporosis Drug Fosamax Initiative &...

PRWeb: Medical Pharmaceuticals — Sat, 21 Jan 2012 05:56:11 +0100

The US Drug Watchdog says, "It sounds counterintuitive, that a drug supposedly devised to fight osteoporosis could also be associated with women, who suffered an out of the blue broken femur...(PRWeb January 19, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9116734.htm (Source: PRWeb: Medical Pharmaceuticals)

New Study Finds Osteoporosis Progresses Slowly; Questions Need For...

PRWeb: Medical Pharmaceuticals — Sat, 21 Jan 2012 05:56:11 +0100

Bernstein Liebhard LLP reports on a January 18, 2012 study questioning whether frequent bone density scans are necessary due to the slow rate at which osteoporosis progresses and the harmful side...(PRWeb January 19, 2012)Read the full story at http://www.prweb.com/releases/fosamax-femur-fractures/consumer-injury-lawyers/prweb9122860.htm (Source: PRWeb: Medical Pharmaceuticals)

Osteoporosis screening interval should vary with BMD status

MedWire News - Bone Health — Sat, 21 Jan 2012 04:19:06 +0100

Baseline bone mineral density should be used to set the interval between osteoporosis screening tests in older women, US researchers recommend in The New England Journal of Medicine. (Source: MedWire News - Bone Health)

NEJM: Osteo screening interval can be extended to 15 years for many

Health Imaging News — Fri, 20 Jan 2012 13:40:28 +0100

Bone mineral density (BMD) screening for osteoporosis should be necessary only every 15 years for postmenopausal women with normal bone density on an initial test, though the screening interval for women with advanced osteopenia should be reduced to one year, according to a study published in the Jan. 19 issue of the New England Journal of Medicine. (Source: Health Imaging News)

Bone Mineral Density Screening For Older Women With Normal T-Scores May Not Needed For 15 Years

Health News from Medical News Today — Fri, 20 Jan 2012 08:00:00 +0100

The U.S. Preventive Services Task Force and other organizations have recommended that women ages 65 and older be routinely screened for osteoporosis using bone mineral density (BMD) screening. However, how often women should be screened is a topic that remains controversial and undecided, with no definitive scientific evidence to provide guidance. Now a new study led by Margaret L. Gourlay, MD, MPH of the University of North Carolina at Chapel Hill School of Medicine finds that women aged 67 years and older with normal bone mineral density scores may not need screening again for 15 years... (Source: Health News from Medical News Today)

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Osteoporosis Is So Slow, Bone Density Retests Can Wait, Study Says

NYT — Fri, 20 Jan 2012 07:37:20 +0100

A new study is asking whether frequent bone density measurements make sense for the majority of older women whose bone density is not close to an osteoporosis danger zone on an initial test. (Source: NYT)

Less found to be best for osteoporosis screening

Health Facts and Fears — Fri, 20 Jan 2012 05:00:00 +0100

Women with normal bone density at age 65 can safely wait as long as 15 years before having another bone density scan, researchers report in a study just published in The New England Journal of Medicine. (Source: Health Facts and Fears)

Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study.

European Journal of Endocrinology — Fri, 20 Jan 2012 05:00:00 +0100

Conclusions. Patterns of increasing subclinical hypercortisolism in adrenal adenomas are associated with increased prevalence of adverse metabolic and cardiovascular outcomes, independently of other potential risk factors. PMID: 22267278 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)

Osteoporosis Is So Slow, Bone Density Retests Can Wait, Study Says

NYT Health — Thu, 19 Jan 2012 16:31:00 +0100

When to Scan

MedlinePlus Health News — Thu, 19 Jan 2012 14:55:47 +0100

Source: HealthDay - Related MedlinePlus Pages: Health Screening, Osteoporosis, Women's Health (Source: MedlinePlus Health News)

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NEJM: 15-year Osteoporosis Screening Gap OK for Many

Diagnostic Imaging — Thu, 19 Jan 2012 12:00:00 +0100

Women with normal bone density are unlikely to develop osteoporosis within 15 years and can forego the duel-energy X-ray absorptiometry (DXA) radiology exams to detect it for at least that long. (Source: Diagnostic Imaging)

Bone mineral density, body composition and bone turnover in patients with congenital hypogonadotropic hypogonadism

International Journal of Andrology — Thu, 19 Jan 2012 09:05:43 +0100

In conclusion, patients with congenital HH require life‐long follow‐up to avoid inadequate HRT, long treatment pauses and further morbidity. (Source: International Journal of Andrology)

A study of bone mineral density and prevalence of osteoporosis in Chinese people of Han nationality from Changchun

Archives of Osteoporosis — Thu, 19 Jan 2012 06:52:28 +0100

Conclusions There was a significant difference (P < 0.01) in BMD in different age groups and between genders within the same age group. In different age groups, the prevalence of osteoporosis was significantly higher in females than in males (P < 0.01). The peak BMD in this region was higher than that reported in Japan and Denmark, and was comparable to that in Beijing. Furthermore, differences were significant (P < 0.01) as Han population of Changchun was compared with Dai population of Xishuangbanna, Tibet, and Dongxiang population of Gansu province. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s11657-011-0066-8Authors Zhang Mengmeng, Bone Metabolism Research Lab, Hospital #4, Jilin University, Changchun, 130011 C...

Age-related changes in proximal humerus bone health in healthy, white males

Osteoporosis International — Thu, 19 Jan 2012 06:51:50 +0100

Conclusion Aging is associated with considerable declines in proximal humeral bone health which, when coupled with a traumatic event such as a fall, may contribute to osteoporotic fracture at this site. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00198-012-1893-1Authors S. M. Mantila Roosa, Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USAA. L. Hurd, Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USAH. Xu, Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USAR. K. Fuchs, Center for Translational Musculoskeletal Research, School...

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Blood — Thu, 19 Jan 2012 05:00:00 +0100

Although activity that induced tumor regression was observed and termed tumor necrosis factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when Aggarwal and coworkers reported, for the first time, the isolation of 2 cytotoxic factors: one, derived from macrophages (molecular mass 17 kDa), was named TNF, and the second, derived from lymphocytes (20 kDa), was named lymphotoxin. Because the 2 cytotoxic factors exhibited 50% amino acid sequence homology and bound to the same receptor, they came to be called TNF-α and TNF-β. Identification of the protein sequences led to cloning of their cDNA. Based on sequence homology to TNF-α, now a total of 19 members of the TNF superfamily have been identified, along with 29 interacting receptors, and sev...

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Osteoporosis Is So Slow, Bone Density Tests Can Wait, Study Says

NYT — Thu, 19 Jan 2012 04:30:09 +0100

A new study is asking whether frequent bone density measurements make sense for the majority of older women whose bone density is not close to a danger zone on an initial test. (Source: NYT)

Osteoporosis ‘markedly undiagnosed’ in elderly men

MedWire News - Bone Health — Thu, 19 Jan 2012 00:00:00 +0100

Osteoporosis and vertebral fractures are common in elderly men, report Danish researchers who also found that osteoporosis in these men is markedly underdiagnosed. (Source: MedWire News - Bone Health)

Osteoporosis Is So Slow, Bone Density Tests Can Wait, Study Says

NYT Health — Wed, 18 Jan 2012 22:50:41 +0100

A new study is asking whether frequent bone density measurements make sense for the majority of older women whose bone density is not close to a danger zone on an initial test. (Source: NYT Health)

The New Old Age Blog: Older Women and Bone Tests

NYT Health — Wed, 18 Jan 2012 22:50:06 +0100

A new study finds that many older women do not need frequent bone testing. But surprisingly few get even a baseline test, experts say. (Source: NYT Health)

Frequent bone density testing not always needed

CTV Health — Wed, 18 Jan 2012 22:01:48 +0100

A new study has found that older women with good, strong bones may not need testing for their risk of osteoporosis as often as once thought. (Source: CTV Health)

Bone-Density Testing Interval and Transition to Osteoporosis in Older Women

New England Journal of Medicine — Wed, 18 Jan 2012 22:00:05 +0100

New England Journal of Medicine, Volume 366, Issue 3, Page 225-233, January 2012. (Source: New England Journal of Medicine)

Some Women Can Go Longer Between Bone Checks

MedlinePlus Health News — Wed, 18 Jan 2012 22:00:00 +0100

Those with normal density may be able to wait more than recommended two years, researcher says Source: HealthDay Related MedlinePlus Pages: Bone Density, Osteoporosis, Women's Health Checkup (Source: MedlinePlus Health News)

Screening Intervals for Osteoporosis Not Carved in Stone (with video)

MedPage Today Endocrinology — Wed, 18 Jan 2012 21:00:00 +0100

(MedPage Today) -- Postmenopausal women with good bone mineral density at an initial osteoporosis screen can probably wait about 15 years before the next test, researchers suggested. (Source: MedPage Today Endocrinology)

Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats

European Journal of Applied Physiology — Wed, 18 Jan 2012 06:59:26 +0100

In conclusion, this study suggested that treadmill training could activate the GSK-3β/β-catenin signaling and inhibit the production of PPARγ in lumbar vertebrae of OVX rats, which may contribute to the prevention of bone loss in OVX rats. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00421-011-2306-4Authors Shumin Bu, Capital University of Physical Education and Sport, 11# Beisanhuanxilu, Haidian District, Beijing, 100191 People’s Republic of ChinaYu Chen, Capital University of Physical Education and Sport, 11# Beisanhuanxilu, Haidian District, Beijing, 100191 People’s Republic of ChinaShouhui Wang, Capital University of Physical Education and Sport, 11# Beisanhuanxilu, Haidian District, Beijing, 100191 People’s Republic of ChinaFan Zhang, C...

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Understand the calcium myth; here's what really makes healthy bones

NaturalNews.com — Wed, 18 Jan 2012 06:00:00 +0100

For years we have been taught that calcium was the great solution to weakened bones. Pre and post-menopausal women are recommended to take calcium supplements to prevent bone loss and osteoporosis. New research has shown that the theory of calcium supplementation improving... (Source: NaturalNews.com)

What Is the Utility of Distal Forearm DXA in Primary Hyperparathyroidism?

The Oncologist — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion. In patients with PHPT, the worst T score is commonly found in the distal forearm. This T score can identify additional patients with a diagnosis of osteopenia or osteoporosis. Distal forearm bone mineral density should, therefore, be assessed in all patients who have a diagnosis of PHPT. PMID: 22258698 [PubMed - as supplied by publisher] (Source: The Oncologist)

Persistence at 1 Year of Oral Anti-osteoporotic Drugs: a Prospective Study in a Comprehensive Health Insurance Database.

European Journal of Endocrinology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusion.Overall persistence at 1 year was low, but intermittent regimens were associated with higher persistence rates, along with women who had therapy monitoring. PMID: 22258112 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)

Heart Failure Is a Clinically and Densitometrically Independent Risk Factor for Osteoporotic Fractures: Population-Based Cohort Study of 45,509 Subjects.

The Journal of Clinical Endocrinology and Metabolism — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions:Heart failure is associated with a 30% increase in major fractures that is independent of traditional risk factors and BMD, and it also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis. PMID: 22259058 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Systemic treatment with pulsed electromagnetic fields do not affect bone microarchitecture in osteoporotic rats

International Orthopaedics — Tue, 17 Jan 2012 07:10:02 +0100

Conclusions Although previous studies have shown strong effects of PEMF in osteoporosis we were unable to demonstrate this in any of the treatment protocols. Using in vivo microCT scanning we were able to identify small bone changes in time. Subtle differences in the experimental set-up might explain the differences in study outcomes in the literature. Since PEMF treatment is safe, future experimental studies on the effect of PEMF on bone can better be performed directly on humans, eliminating the potential translation issues between animals and humans. In this study we found no support for the use of PEMF in the treatment of osteoporosis. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00264-011-1471-8Authors Olav P. van der Jagt, Departm...

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Vitamin D in the New Millennium

Current Osteoporosis Reports — Tue, 17 Jan 2012 07:05:33 +0100

Abstract The incidence of vitamin D deficiency is rising worldwide, yet in the vast majority of patients, the condition remains undiagnosed and untreated. Current evidence overwhelmingly indicates that supplemental doses greater than 800 IU/day have beneficial effects on the musculoskeletal system, improving skeletal homeostasis, thus leading to fewer falls and fractures. Evidence is also accumulating on the beneficial effects of vitamin D on extraskeletal systems, such as improving immune health, autoimmune disorders, cancer, neuromodulation, diabetes, and metabolic syndrome. The cause-effect relationship of vitamin D deficiency with increasing incidences of nonskeletal disorders is being investigated. Published reports support the definition of sufficiency, serum le...

Reply to the Letter by E. Czerwinski Regarding “The Utility and Limitations of FRAX: A US Perspective”

Current Osteoporosis Reports — Tue, 17 Jan 2012 07:05:31 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s11914-011-0092-xAuthors Stuart L. Silverman, Cedars-Sinai Medical Center, Los Angeles, CA, USAAndrew D. Calderon, The OMC Clinical Research Center, Beverly Hills, CA, USA Journal Current Osteoporosis ReportsOnline ISSN 1544-2241Print ISSN 1544-1873 (Source: Current Osteoporosis Reports)

Weight Loss: Is Bypass Better than Banding?

MedicineNet Osteoporosis General — Tue, 17 Jan 2012 07:00:00 +0100

Title: Weight Loss: Is Bypass Better than Banding?Category: Health NewsCreated: 1/17/2012 11:00:00 AMLast Editorial Review: 1/17/2012 (Source: MedicineNet Osteoporosis General)

Natural polyamines spermidine and spermine prevent bone loss through preferential disturbance of osteoclastic activation in ovariectomized mice

British Journal of Pharmacology — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions and Implications. Particular natural polyamines prevented OVX‐induced bone loss through a mechanism related to the disturbance of differentiation and maturation of osteoclasts rather than osteoblasts. Our results suggest that supplementation of particular natural polyamines would be beneficial for the prophylaxis as well as the therapy of metabolic bone diseases such as postmenopausal osteoporosis. (Source: British Journal of Pharmacology)

Screening for Osteoporosis in Men Receiving Androgen Deprivation Therapy [Research Letters]

JAMA — Tue, 17 Jan 2012 05:00:00 +0100

(Source: JAMA)

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Suppression of Zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts

Journal of Translational Medicine — Tue, 17 Jan 2012 05:00:00 +0100

In this study, a comparative analysis of gene expression profiling using cDNA microarray and realtime-PCR indicated that Zinc finger protein 467 (Zfp467) involved in adipocyte and osteoblast differentiation of cultured adipose derived stem cells (ADSCs). Our results showed that RNA interference for Zfp467 in ADSCs inhibited adipocyte formation and stimulated osteoblast commitment. The mRNA levels of osteogenic and adipogenic markers in ADSCs were regulated by si-Zfp467. Zfp467 RNAi in ADSCs could restore bone function and structure in an ovariectomized (OVX)-induced osteoporotic mouse model. Thus Zfp467 play an important role in ADSCs differentiation to adipocyte and osteoblast. This has relevance to therapeutic interventions in osteoporosis, including si-Zfp467-based therapies currently a...

Bone mineral density, body composition and bone turnover in patients with congenital hypogonadotropic hypogonadism.

International Journal of Andrology — Tue, 17 Jan 2012 05:00:00 +0100

In conclusion, patients with congenital HH require life-long follow-up to avoid inadequate HRT, long treatment pauses and further morbidity. PMID: 22248317 [PubMed - as supplied by publisher] (Source: International Journal of Andrology)

Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE Trial Bone Sub-study

Breast Cancer Research — Tue, 17 Jan 2012 05:00:00 +0100

IntroductionLivial Intervention Following Breast Cancer; Efficacy, Recurrence and Tolerability Endpoints (LIBERATE - ClinicalTrials.gov number NCT00408863), a randomized, placebo controlled, double-blind trial which demonstrated that tibolone (Livial), a tissue selective hormone replacement therapy (HRT) increased breast cancer (BC) recurrence HR 1.40 (95% CI 1.14-1.70; p=0.001) entered a subgroup of women into a study of Bone Mineral Density (BMD). Methods: Women with surgically excised primary BC (T1-3, N0-2, M0) within the last 5 years complaining of vasomotor symptoms, were assigned to tibolone 2.5mg daily or placebo treatment for a maximum of 5 years. The BMD sub-study enrolled 763 patients utilizing dual-energy X-ray absorptiometry (DXA) scanning at baseline and at 2 years. Results: ...

High doses of vitamin d to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.

Annals of Internal Medicine — Tue, 17 Jan 2012 05:00:00 +0100

Conclusion: High-dose vitamin D supplementation in a sample of patients with COPD did not reduce the incidence of exacerbations. In participants with severe vitamin D deficiency at baseline, supplementation may reduce exacerbations. Primary Funding Source: Applied Biomedical Research Program, Agency for Innovation by Science and Technology (IWT-TBM). PMID: 22250141 [PubMed - in process] (Source: Annals of Internal Medicine)

National Osteoporosis Society Research Grants

Society for Endocrinology — Mon, 16 Jan 2012 12:00:00 +0100

The National Osteoporosis Society is now accepting applications for its research grants. Up to £250,000 is available to fund projects which clearly demonstrate potential benefits to those people with or at risk of osteoporosis. The following types of award are available: Linda Edwards Memorial PhD Studentship - maximum of £25,000 per annum for up to four years; Project Grants - maximum of £150,000 over three years; Innovative Awards - maximum of £20,000 to allow researchers to test hypotheses for a maximum of 12 months. For more information and full details of how to apply please follow the link below. The deadline for applications is 2 March 2012. Young Scientist Prize - The National Osteoporosis Society also offers funds to support the careers' of young researchers...

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Enormous growth in use of WHO Fracture Risk Assessment Tool

EurekAlert! - Medicine and Health — Mon, 16 Jan 2012 05:00:00 +0100

(International Osteoporosis Foundation) The widely used WHO Fracture Risk Assessment Tool has now been released as version 3.5. The tool now includes new models for Ecuador, Norway, Russia, Slovakia and Sri Lanka. The model for Sri Lanka is the first surrogate model, built by combining national mortality data with hip fracture data from a representative, surrogate country. (Source: EurekAlert! - Medicine and Health)

Bisphosphonate Side Effects

About.com Eating Disorders — Mon, 16 Jan 2012 05:00:00 +0100

Osteoporosis is a condition that causes thinning and weakening of the bone, and may lead to fracture. Medications called bisphosphonates are commonly used in the treatment of osteoporosis. Learn about common side effects of bisphosphonate medications used in the treatment of osteoporosis. (Source: About.com Eating Disorders)

Diagnosis of osteoporosis from dental panoramic radiographs using the support vector machine method in a computer-aided system

BMC Medical Imaging - Latest articles — Mon, 16 Jan 2012 05:00:00 +0100

Conclusion: Our results suggest that the newly developed system with the SVM method would be useful for identifying postmenopausal women with low skeletal BMD. (Source: BMC Medical Imaging - Latest articles)

Effectiveness of Teriparatide in Postmenopausal Women with Osteoporosis and Glucocorticoid Use: 3-Year Results from the EFOS Study.

J Rheumatol — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: Postmenopausal women with severe osteoporosis receiving GC, who were treated with teriparatide for up to 18 months, showed a reduced incidence of clinical fractures during the third year while receiving sequential osteoporosis treatments compared with the first 6 months, together with reduced back pain and improved HRQOL. Our results should be interpreted in the context of an uncontrolled observational study in a routine clinical setting. PMID: 22247365 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Adverse Events During Longterm Low-dose Glucocorticoid Treatment of Polymyalgia Rheumatica: A Retrospective Study.

J Rheumatol — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: Longterm, low-dose GC treatment of PMR is associated with serious adverse events such as osteoporosis, fractures, and arterial hypertension; these adverse events occur mostly after 2 years of treatment. PMID: 22247343 [PubMed - as supplied by publisher] (Source: J Rheumatol)

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US Drug Watchdog Calls For Increased National Awareness Of...

PRWeb: Medical Pharmaceuticals — Sat, 14 Jan 2012 17:41:50 +0100

The US Drug Watchdog says, "We are trying to identify every woman in the United States, who has been using, any type of osteoporosis drug, or the osteoporosis drug called Fosamax for at least...(PRWeb January 11, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9094495.htm (Source: PRWeb: Medical Pharmaceuticals)

Femoral neck fracture following hardware removal.

Orthopedics — Sat, 14 Jan 2012 15:24:05 +0100

This article describes a case of a 57-year-old man with a high-energy ipsilateral inter-trochanteric hip fracture, comminuted distal third femoral shaft fracture, and displaced lateral tibial plateau fracture. Cephalomedullary fixation was used to fix the ipsilateral femur fractures after medical stabilization and evaluation of the patient. The patient healed clinically and radiographically at 6 months. Despite conservative treatment for painful proximal hardware, elective hip screw removal was performed 22.5 months after injury. Seven weeks later, he sustained a nontraumatic femoral neck fracture.In this case, it is unlikely that the femoral neck fracture occurred as a result of hardware removal. We assumed that, in addition to the patient's alcohol abuse and tobacco use, stress fractures...

Corona mortis artery avulsion due to a stable pubic ramus fracture.

Orthopedics — Sat, 14 Jan 2012 15:24:05 +0100

Authors: Garrido-Gómez J, Pena-Rodríguez C, Martín-Noguerol T, Hernández-Cortes P Abstract A 70-year-old woman with osteoporosis fell at home and presented to our emergency department with intense left hip pain. Radiographs revealed a left iliopubic rami fracture and nondisplaced right ischiopubic rami fracture. She was discharged after a 24-hour observation with no clinical changes. Seventy-two hours later, she was readmitted with a painful abdominal mass, progressive oliguria, tachycardia, hypotension, and profuse perspiration with generalized pallor. On physical examination, a painful mass in the hypogastrium and intense inflammation in the thigh and the proximal portion of left knee were found.Emergent multiphase contrast computed tomography revealed a large nonhomogeneous ...

Hip fracture incidence is decreasing in the high incidence area of Oslo, Norway

Osteoporosis International — Sat, 14 Jan 2012 06:55:16 +0100

Conclusions The incidence of hip fractures in women in Oslo has decreased significantly during the last decade and is now at a lower level than in 1978/1979. This reduction was not evident in men. The incidence of hip fractures in Oslo is, however, still the highest in the world. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00198-011-1888-3Authors R. Ø. Støen, Department of Orthopaedics, Oslo University Hospital, Ullevål, 0424 Oslo, NorwayL. Nordsletten, Department of Orthopaedics, Oslo University Hospital, Ullevål, 0424 Oslo, NorwayH. E. Meyer, Division of Epidemiology, Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, NorwayJ. F. Frihagen, Department of Orthopaedics, Oslo University Hospital, Ullevål, 04...

Downregulation of Ferroportin 1 Expression in hFOB1.19 Osteoblasts by Hepcidin

Inflammation — Sat, 14 Jan 2012 06:54:55 +0100

Abstract The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was analyzed by RT-PCR and western blotting. The results showed the presence of ferroportin 1 expression in cultured hFOB 1.19 cells. Furthermore, the ferroportin 1 had a similar expression pattern in hFOB cells as in hepatocytes and enterocytes and was downregulated by hepcidin. Our data indicate that osteoblasts are target cells for hepcidin, suggest that hepcidin may have many more targets than previously recognized, and support the role of ...

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Antiretrovirals: Osteoporosis?: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Parathyroid carcinoma presenting as normocalcemic hyperparathyroidism

Journal of Bone and Mineral Metabolism — Fri, 13 Jan 2012 16:58:18 +0100

We describe the case of a 62-year-old woman with a 2-year history of asthenia and mental depression. Her past medical history was significant for osteoporosis. A diagnosis of primary normocalcemic hyperparathyroidism was established and the patient underwent surgery. PC was suspected intraoperatively because of the size and appearance of the parathyroid mass (a grayish, lobulated 3.5 cm mass). Thus, aggressive surgery (en bloc resection) was performed, along with bilateral neck exploration. Pathological examination of the specimens confirmed the suspicion of PC, demonstrating vascular invasion and extracapsular infiltration into adjacent soft tissue. Immunohistochemical staining revealed an elevated Ki-67 score (8.43%; cut-off value 5%). The mean area of silver-stained nucleolar orga...

Self-reported recreational exercise combining regularity and impact is necessary to maximize bone mineral density in young adult women

Osteoporosis International — Fri, 13 Jan 2012 16:57:26 +0100

Conclusion Self-reported recreational levels of physical activity positively influence BMD in young adult women but to maximize BMD gains, regular, high-impact exercise is required. Enjoyment of exercise contributes to regularity of exercising which has short- and long-term implications for bone health. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00198-011-1886-5Authors M. Callréus, Department of Orthopaedics, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenF. McGuigan, Department of Orthopaedics, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenK. Ringsberg, Department of Orthopaedics, Lund University, Skåne University Hospital, 205 02 Malmö, SwedenK. Åkesson, Department of Orthopaedics, Lund Un...

The Role of Vitamin D in the Metabolic Homeostasis of Diabetic Bone

Clinical Reviews in Bone and Mineral Metabolism — Fri, 13 Jan 2012 16:50:22 +0100

Abstract Most studies across a variety of geographic locations suggest that vitamin D insufficiency is more common in individuals with type 1 diabetes (T1D) compared to the general population. In type 2 diabetes (T2D), while obesity is commonplace and lower vitamin D levels are present in obese adolescents and adults, the association between vitamin D insufficiency and T2D is less clear. Studies suggest that the relationship between T2D and vitamin D may be concurrently influenced by ethnicity, geography, BMI and age. Nonetheless, diabetic osteopathy is a significant comorbidity of both forms of diabetes and is characterized by micro-architectural changes that decrease bone quality leading to an increased risk for bone fracture in both disorders. The question remains, howe...

DTB reviews denosumab for postmenopausal osteoporosis

NeLM - Drug Specific Reviews — Fri, 13 Jan 2012 05:00:00 +0100

This article in the Drug and Therapeutics Bulletin (DTB) reviews the evidence on the efficacy and tolerability of, and guidelines for, denosumab in the management of postmenopausal osteoporosis. Denosumab is a monoclonal antibody given subcutaneously every six months, licensed for the treatment of osteoporosis in postmenopausal women at increased risk of fractures (and also for the treatment of bone loss associated with hormone ablation in men with prostate cancer at increased risk of fractures). The review notes that it reduces the incidence of new radiological vertebral fractures compared to placebo in postmenopausal women with osteoporosis when taken for three years. Although there are no published trials comparing denosumab with alendronic acid in terms of ...

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Osteodystrophy in chronic liver diseases

Internal and Emergency Medicine — Thu, 12 Jan 2012 16:47:58 +0100

Abstract Osteoporosis and osteomalacia are, to date, among the most common metabolic diseases in the world. Lately, an association between metabolic bone diseases and chronic liver disease has been increasingly reported, inducing many authors to create a new nosographic entity known as ‘hepatic osteodystrophy.’ The importance of such a condition is further increased by the morbidity of these two diseases, which greatly reduce the quality of life because of frequent fractures, especially vertebral and femoral neck ones. For this reason, early identification of high-risk patients should be routinely performed by measuring bone mass density. The explanation for the association between bone diseases and chronic liver disease is still uncertain, and involves many factors: f...

Adherence to the U.S. Preventive Services Task Force 2002 Osteoporosis Screening Guidelines in Academic Primary Care Settings

Journal of Women — Thu, 12 Jan 2012 16:28:16 +0100

Journal of Women's Health Jan 2012, Vol. 21, No. 1: 50-53. (Source: Journal of Women)

Effects of Increasing Age, Dosage, and Duration of PTH Treatment on BMD Increase—A Meta-analysis

Calcified Tissue International — Thu, 12 Jan 2012 06:41:19 +0100

Abstract We studied the effects of increasing age, dosage, and duration of parathyroid hormone (PTH) treatment on changes in bone mineral density (BMD). Randomized placebo controlled trials on PTH treatment in men or women were retrieved from PubMed (1951 to present), Web of Science (1945 to present), or Embase (1974 to present). The search date was November 16, 2010. All studies comparing PTH treatment to either placebo or antiresorptive drugs—for example, bisphosphonates or hormone replacement therapy—were included. A total of 214 studies were identified in the initial search, and 15 of these trials were included. By metaregression analysis, we found that the increase in spine BMD (Z-score) after PTH treatment was blunted by increasing age (R 2 = 0.27; 2p&n...

The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml

Osteoporosis International — Thu, 12 Jan 2012 06:41:06 +0100

Conclusions Patients with a mean 25(OH)D ≥33 ng/ml had a substantially greater likelihood of maintaining bisphosphonate response. This threshold level of 25(OH)D is higher than that considered adequate by the Institute of Medicine, arguing that higher levels may be required for specific therapeutic outcomes. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00198-011-1868-7Authors A. S. Carmel, Department of Internal Medicine, Weill Cornell Medical College, 505 East 68th Street, New York, NY 10021, USAA. Shieh, Department of Internal Medicine, Weill Cornell Medical College, 505 East 68th Street, New York, NY 10021, USAH. Bang, Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College, 402 E...

Growth from birth to adulthood and peak bone mass and density data from the New Delhi Birth Cohort

Osteoporosis International — Thu, 12 Jan 2012 06:41:06 +0100

Conclusions Greater skeletal growth and BMI gain in utero and during infancy are associated with higher peak BMC, and greater BMI gain in childhood and adolescence is associated with higher peak aBMD and BMAD. These associations are mediated by the attainment of adult height and BMI, respectively. Content Type Journal ArticleCategory Original ArticlePages 1-13DOI 10.1007/s00198-011-1857-xAuthors N. Tandon, Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaC. H. D. Fall, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UKC. Osmond, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UKH. P. S. Sachdev, Sitaram Bhartia Institute of Science and Research, New Delhi, IndiaD. ...

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Precision of 18F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism

Osteoporosis International — Thu, 12 Jan 2012 06:41:02 +0100

Conclusions SUV measurements showed the smallest precision error followed by the Patlak method, while the Hawkins method gave the largest error. Measuring a smaller region of interest did not increase the precision error, suggesting that the factor determining the errors may be scanner calibration. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00198-011-1889-2Authors Y. Al-beyatti, Osteoporosis Screening & Research Unit, Guy’s Hospital, King’s College London, 1st Floor, Tower Wing, London, SE1 9RT UKM. Siddique, Osteoporosis Screening & Research Unit, Guy’s Hospital, King’s College London, 1st Floor, Tower Wing, London, SE1 9RT UKM. L. Frost, Osteoporosis Screening & Research Unit, Guy’s Hospital, King’s College London, 1st F...

Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year

Osteoporosis International — Thu, 12 Jan 2012 06:41:01 +0100

Conclusions Trabecular level stresses associated with microdamage do not continue to decrease with prolonged alendronate treatment. Changes in mineralization may account for these findings. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00198-011-1875-8Authors J. O. Green, Parker H. Petit Institute for Bioengineering and Bioscience and George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332-0405, USAT. Diab, Parker H. Petit Institute for Bioengineering and Bioscience and George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332-0405, USAM. R. Allen, Department of Anatomy and Cell Biology, Indiana University School...

Vitamin D status and physical activity interact to improve bone mass in adolescents. The HELENA Study

Osteoporosis International — Thu, 12 Jan 2012 06:41:01 +0100

Conclusions Vitamin D and PA may interact to determine BMC. 25(OH)D sufficiency levels improve bone mass only in active adolescents, or PA has a positive influence on BMC in individuals with replete vitamin D levels. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s00198-011-1884-7Authors J. Valtueña, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences–INEF, Technical University of Madrid, C/ Martín Fierro, 7, 28040 Madrid, SpainL. Gracia-Marco, GENUD (Growth, Exercise, Nutrition and Development) Research Group, Zaragoza, SpainG. Vicente-Rodríguez, GENUD (Growth, Exercise, Nutrition and Development) Research Group, Zaragoza, SpainM. González-Gross, Department of Health and Human Performance, Fac...

A crosstalk between bone and gonads

Annals of the New York Academy of Sciences — Thu, 12 Jan 2012 05:00:00 +0100

The sex steroid hormones testosterone and estrogen are essential determinants not only of reproductive functions but also for bone growth and the maintenance of skeletal integrity. The importance of this latter form of regulation is best exemplified by the fact that gonadal failure triggers bone loss in both genders and causes osteoporosis in postmenauposal women. Traditionally, bone physiology is studied with the view that the skeleton is simply a recipient of hormonal inputs. However, a richer picture of bone physiology has recently emerged, and it is now clear that the skeleton is an endocrine organ itself. This is particularly relevant to the interplay between bone and gonads because genetics and biochemical evidence have established that bone, via the osteoblast‐derived hormone oste...