MedWorm: Psoriasis

The role of the HLA-G gene and molecule on the clinical expression of rheumatologic diseases

Revista Brasileira de Reumatologia — Fri, 03 Feb 2012 10:19:07 +0100

O antígeno leucocitário humano G (HLA-G) é uma molécula não clássica de complexo principal de histocompatibilidade (MHC) de classe I, caracterizada por baixo polimorfismo em sua região codificadora, um padrão de distribuição tecidual limitado em condições fisiológicas e expressão por meio de isoformas solúveis e acopladas à superfície de membranas por meio de splicing alternativo. O HLA-G é bastante conhecido por estar envolvido na indução e na manutenção da tolerância entre o sistema imunológico materno e o feto semialogênico ao nível da interface fetoplacentária. Além disso, diversos estudos apontam para um papel imunorregulatório mais amplo dessa molécula. Neste contexto, a expressão de HLA-G em doenças inflamatórias e reumatológicas é uma área relati...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Current and relevant concepts in psoriatic arthritis

Revista Brasileira de Reumatologia — Fri, 03 Feb 2012 10:19:07 +0100

A artrite psoriásica (APs) é uma doença articular sistêmica e polimórfica de apresentação e curso clínico variáveis, associada a comorbidades importantes como diabetes mellitus, hipertensão arterial e dislipidemia. Para o diagnóstico precoce da doença é necessário alto grau de suspeita clínica, sobretudo quando as manifestações cutâneas são sutis e pouco definidas. Doença erosiva progressiva pode ocorrer em até metade dos pacientes, associada a alterações anatômicas e funcionais em cerca de 20%, de modo que o prognóstico da APs permanece obscuro, especialmente se diagnóstico e tratamento forem tardios. Fundamentados em ampla revisão da literatura (PubMed e Lilacs) e experiência dos nossos serviços, novos conceitos de imunogenética, fisiopatologia, aspectos cl�...

Smoking tied to higher psoriasis risk: study

Reuters: Health — Fri, 03 Feb 2012 00:52:06 +0100

NEW YORK (Reuters Health) - Adding to the list of possible health consequences from smoking, a large study suggests that smokers have an increased risk of developing the chronic skin condition psoriasis. (Source: Reuters: Health)

Smoking tied to higher psoriasis risk

Reuters: Health — Thu, 02 Feb 2012 21:26:02 +0100

Smoking Tied to Higher Psoriasis Risk

MedlinePlus Health News — Thu, 02 Feb 2012 21:25:58 +0100

Adding to the list of possible health consequences from smoking, a large study suggests that smokers have an increased risk of developing the chronic skin condition psoriasis.Source: Reuters Health Related MedlinePlus Pages: Psoriasis, Smoking (Source: MedlinePlus Health News)

Quality-of-Life Instruments: Evaluation of the Impact of Psoriasis on Patients

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

The negative impact of psoriasis on a patient's quality of life (QoL) is well documented in the literature. Patients often suffer poor self-esteem, difficulties in social interactions, and significant psychological distress. It is, therefore, critically important that a clinician evaluate the extent to which the disease impacts a patient's QoL. This chapter reviews several validated and reliable generic, dermatology-specific, and disease-specific QoL instruments useful in measuring the impact of psoriasis on patient's QoL. These QoL instruments can be especially helpful in identifying those patients who would most benefit from systemic or biologic therapy. (Source: Dermatologic Clinics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Femoral head osteonecrosis after long‐term topical corticosteroid treatment in a psoriasis patient

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

(Source: The Journal of Dermatology)

Linear Pitting and Splinter Haemorrhages Are More Commonly Seen in the Nails of Patients with Established Psoriasis in Comparison to Psoriatic Arthritis

Dermatology — Wed, 01 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000335571) (Source: Dermatology)

Eosinophilia during Psoriasis Treatment with TNF Antagonists

Dermatology — Wed, 01 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000334805) (Source: Dermatology)

Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin

The Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

AbstractCyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte‐derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte‐derived cytokines in psoriatic patients. This case–control study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index‐matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels ...

Accuracy of dermoscopic criteria for the diagnosis of psoriasis, dermatitis, lichen planus and pityriasis rosea

British Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: PP, LP, PR and dermatitis show specific dermoscopic patterns that may aid their clinical diagnosis. Certain combinations of dermoscopic features can reliably predict the diagnosis of PP. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Use of digital infrared imaging in the assessment of childhood psoriasis

Skin Research and Technology — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Skin Research and Technology)

VTE risk elevated in people with psoriasis

MedWire News - Thrombosis — Wed, 01 Feb 2012 00:00:00 +0100

People with psoriasis may have an increased risk for venous thromboembolism, results from a large study among US women suggest. (Source: MedWire News - Thrombosis)

Psoriasis: an evidence-based update. Report of the 9th Evidenced Based Update Meeting, 12 May 2011, Loughborough, U.K.

The British Journal of Dermatology — Tue, 31 Jan 2012 08:00:39 +0100

Authors: De Mozzi P, Johnston GA, Alexandroff AB Abstract The Centre of Evidence Based Dermatology, University of Nottingham, U.K. holds an annual Evidence Based Update (EBU) Meeting focused on important dermatological topics, which have in the past included eczema, urticaria, blistering disorders, skin infections, skin cancer and hair disorders. These one-day meetings aim to summarize the most recent evidence in the form of systematic reviews and recently completed clinical trials. This year, the 9th EBU meeting took place in Loughborough, U.K. on 12 May 2011 and was devoted to psoriasis. The latest updates on topical treatments, nail psoriasis, genetics and clinical implications, rational use of biologics, new and unpublished studies on combination of phototherapy and biologics f...

Biologics in the Treatment of Moderate to Severe PsoriasisBiologics in the Treatment of Moderate to Severe Psoriasis

Medscape Today Headlines — Tue, 31 Jan 2012 04:00:00 +0100

This study assessed the comparative effectiveness of five biologic agents currently approved in Europe for the treatment of moderate to severe psoriasis. How do they rank? The British Journal of Dermatology (Source: Medscape Today Headlines)

Alopecia Areata during Treatment of Psoriasis with Adalimumab and Leflunomide: A Case and Review of the Literature

Skin Pharmacology and Physiology — Mon, 30 Jan 2012 23:00:00 +0100

Skin Pharmacol Physiol 2012;25:107–110 (DOI:10.1159/000335264) (Source: Skin Pharmacology and Physiology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

ADAM33 gene variants associated with psoriasis

MedWire News - Psoriasis — Sun, 29 Jan 2012 17:40:17 +0100

Variants in a disintegrin and metalloproteinase 33 gene are associated with psoriasis in Han Chinese people, suggest study results. (Source: MedWire News - Psoriasis)

New Psoriasis Guidelines Expand Treatment Options (CME/CE)

MedPage Today Dermatology — Sun, 29 Jan 2012 16:13:02 +0100

(MedPage Today) -- Newer biologic agents for treating moderate-to-severe plaque psoriasis can be considered for first-line use in some cases, according to new treatment guidelines from the National Psoriasis Foundation. (Source: MedPage Today Dermatology)

Psoriasis is Associated with Greater Risk of Incident Venous Thromboembolism: The Iowa Women’s Health Study

Journal of Thrombosis and Haemostasis — Sat, 28 Jan 2012 05:00:00 +0100

(Source: Journal of Thrombosis and Haemostasis)

Serum neurotensin (NT) is increased in psoriasis and NT induces VEGF release from human mast cells.

British Journal of Dermatology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion NT may play a role in Ps pathogenesis and its worsening with stress, at least through activation of skin mast cells. (Source: British Journal of Dermatology)

Vaspin ‐ a link of obesity and psoriasis?

Experimental Dermatology — Fri, 27 Jan 2012 05:00:00 +0100

AbstractPsoriasis is an inflammatory skin disease often associated with obesity. The anti‐inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here we demonstrate that ‐ different from healthy controls ‐ vaspin serum levels in psoriatic patients were BMI‐independent. Moreover, we could identify keratinocytes as the major source of vaspin in skin. Vaspin expression in lesional psoriatic skin was reduced compared to uninvolved skin as shown by immunohistochemistry and RT‐PCR. In aggregate we report on the cellular source of vaspin in skin and its expression in psoriasis. (Source: Experimental Dermatology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Cathelicidin LL‐37: A Defence Molecule with a Potential Role in Psoriasis Pathogenesis

Experimental Dermatology — Fri, 27 Jan 2012 05:00:00 +0100

AbstractEpidermal keratinocytes produce and secrete antimicrobial peptides which subsequently form a chemical shield on the skin surface. Cathelicidins are one family of antimicrobial peptides in skin with various further immune functions. Consequently, dysfunction of these peptides has been implicated in the pathogenesis of inflammatory skin disease. In particular, the cathelicidin LL‐37 is overexpressed in inflamed skin in psoriasis, binds to extracellular self‐DNA released from dying cells and converts self‐DNA in a potent stimulus for plasmacytoid dendritic cells (pDCs). Subsequently, pDCs secrete type‐I interferons and trigger an auto‐inflammatory cascade. Paradoxically, therapies targeting the vitamin D pathway such as vitamin D analogues or UVB phototherapy ameliorate cuta...

MiR‐21 is up‐regulated in psoriasis and suppresses T cell apoptosis

Experimental Dermatology — Fri, 27 Jan 2012 05:00:00 +0100

AbstractMicroRNAs are short non‐coding RNAs that regulate gene expression. Previously, in a genome‐wide screen we found deregulation of microRNA expression in psoriasis skin. MicroRNA‐21 (miR‐21) is one of the microRNAs significantly up‐regulated in psoriasis skin lesions. In order to identify the cell type responsible for the increased miR‐21 level, we compared expression of miR‐21 in epidermal cells and dermal T cells between psoriasis and healthy skin and found elevated levels of miR‐21 in psoriasis in both cell types. In cultured T cells, expression of miR‐21 increased markedly upon activation. In order to explore the function of miR‐21 in primary human T helper cells, we inhibited miR‐21 using a tiny seed‐targeting LNA‐antimiR. Specific inhibition of miR‐21...

ADAM33 gene variants associated with psoriasis

MedWire News - Dermatology — Fri, 27 Jan 2012 00:00:00 +0100

Variants in a disintegrin and metalloproteinase 33 gene are associated with psoriasis in Han Chinese people, suggest study results. (Source: MedWire News - Dermatology)

Clinical and Histologic Diagnostic Guidelines for Psoriasis: A Critical Review

Clinical Reviews in Allergy and Immunology — Thu, 26 Jan 2012 06:43:59 +0100

Abstract Psoriasis is a common inflammatory skin disease that is associated with joint, psychiatric, and cardiovascular comorbidities. Diagnosis of plaque psoriasis is dependent primarily on characteristic physical findings and history. Given the varied clinical presentations of psoriasis and its mimicry to other papulosquamous skin diseases, it may be difficult for nondermatologists to diagnose psoriasis. Currently, no diagnostic criteria for plaque psoriasis have been validated in clinical studies. In this paper, we provide diagnostic guidelines for the nondermatologist to aid them in recognizing psoriasis. Content Type Journal ArticlePages 1-7DOI 10.1007/s12016-012-8305-3Authors Mary Ann N. Johnson, Department of Dermatology, University of California Davis, 3301 C ...

Elicitation and Use of Patients' Preferences in the Treatment of Psoriasis: A Systematic Review.

Acta Dermato-Venereologica — Thu, 26 Jan 2012 05:00:00 +0100

Authors: Umar N, Yamamoto S, Loerbroks A, Terris D Abstract There is a growing advocacy to incorporate patients' preferences in psoriasis treatment. The aim of this study was to critically review the scientific evidence regarding the elicitation and use of patients' preferences in psoriasis treatment. Published studies were systematically identified through PubMed, the Cochrane Library, the Web of Knowledge, and PsychINFO. Additional studies were identified by reviewing the reference lists of retrieved articles and through contact with experts in the field. Included studies involved the elicitation or use of patient preferences related to the treatment of psoriasis or psoriatic arthritis. Twenty-three studies were included in the review. The earliest articles were published in the ...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Briakinumab versus Methotrexate for Psoriasis

New England Journal of Medicine — Wed, 25 Jan 2012 22:00:08 +0100

New England Journal of Medicine, Volume 366, Issue 4, Page 379-380, January 2012. (Source: New England Journal of Medicine)

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis

International Journal of Photoenergy — Tue, 24 Jan 2012 18:18:57 +0100

CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, dermatomyositis, primary biliary cirrhosis, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo, bullous pemphigoid, alopecia areata, idiopathic dilated cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis, IgA nephropathy, membranous nephropathy, and pernicious anaemia. It also occurs in healthy blood relatives of patients with autoimmune diseases, suggesting it is genetically determined. Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune dise...

The Genetics of Psoriasis and Psoriatic Arthritis

Clinical Reviews in Allergy and Immunology — Tue, 24 Jan 2012 12:27:23 +0100

This article reviews the current status of genetic studies in psoriasis and PsA. Content Type Journal ArticlePages 1-8DOI 10.1007/s12016-012-8303-5Authors Vinod Chandran, Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada Journal Clinical Reviews in Allergy and ImmunologyOnline ISSN 1559-0267Print ISSN 1080-0549 (Source: Clinical Reviews in Allergy and Immunology)

Psoriasis in humans is associated with downregulation of galectins in dendritic cells

The Journal of Pathology — Tue, 24 Jan 2012 05:23:43 +0100

AbstractWe have investigated the expression and role of galectin‐1 and other galectins in psoriasis and in the Th1/Th17 effector and dendritic cell responses associated with this chronic inflammatory skin condition. To determine differences between psoriasis patients and healthy donors, expression of galectins was analyzed by RT‐PCR in skin samples and on epidermal and peripheral blood dendritic cells by immunofluorescence and flow cytometry. In skin of healthy donors, galectins 1, 3 and 9 were expressed in a high proportion of Langerhans cells. Also, galectins were differentially expressed in peripheral blood dendritic cell subsets; galectin‐1 and galectin‐9 were highly expressed in peripheral myeloid dendritic cells compared with plasmacytoid dendritic cells. We found that non‐...

FLEXITOL NATURALS ECZEMA AND PSORIASIS (Sodium Borate, Graphite, Potassium Sulfate, And Sodium Chloride) Cream [LaCorium Health International Pty Ltd]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 24 Jan 2012 05:00:00 +0100

Updated Date: Jan 24, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

NATRALIA ECZEMA AND PSORIASIS (Sodium Borate, Graphite, Potassium Sulfate, And Sodium Chloride) Cream [LaCorium Health International Pty Ltd]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 24 Jan 2012 05:00:00 +0100

Updated Date: Jan 24, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Consultants insist it really works but can talking about your emotions clear up bad skin?

the Mail online | Health — Mon, 23 Jan 2012 22:55:08 +0100

Ruby Jaffrey suddenly developed severe psoriasis. Within weeks, 80 per cent of her body was covered with the characteristic scabs. (Source: the Mail online | Health)

Insulin: Exacerbation of psoriasis: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

Mesalazine: Psoriasis: 2 case reports

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

Psoriatic Arthritis - New Drug Offers Relief

Health News from Medical News Today — Mon, 23 Jan 2012 18:00:00 +0100

Around 7.5 million Americans, which is about 2.2% of the population, suffer from psoriaris, an autoimmune disease causing red, flaky skin. A new review in the Journal of the American Academy of Orthopedic Surgeons (JAAOS) reveals that patients with psoriatic arthritis (PsA), a type of arthritis that affects nearly 48% of patients with the skin disease psoriasis, gain substantial benefits from medications or biologic agents that target T-cells, white blood cells involved in the body's immune system. Lead study author Michael S. Day, M.D... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China

Dermatology — Mon, 23 Jan 2012 17:39:42 +0100

Dermatology (DOI:10.1159/000335417) (Source: Dermatology)

Psoriasis: an evidence‐based update. Report of the 9th Evidenced Based Update Meeting, 12 May 2011, Loughborough, U.K.

British Journal of Dermatology — Mon, 23 Jan 2012 17:25:45 +0100

SummaryThe Centre of Evidence Based Dermatology, University of Nottingham, U.K. holds an annual Evidence Based Update (EBU) Meeting focused on important dermatological topics, which have in the past included eczema, urticaria, blistering disorders, skin infections, skin cancer and hair disorders. These one‐day meetings aim to summarize the most recent evidence in the form of systematic reviews and recently completed clinical trials. This year, the 9th EBU meeting took place in Loughborough, U.K. on 12 May 2011 and was devoted to psoriasis. The latest updates on topical treatments, nail psoriasis, genetics and clinical implications, rational use of biologics, new and unpublished studies on combination of phototherapy and biologics for psoriasis, and on treatments of palmoplantar pustular ...

Psoriasin potential target for psoriasis therapy

MedWire News - Psoriasis — Fri, 20 Jan 2012 17:36:29 +0100

Research suggests that blocking the formation of psoriasin, a protein that is abundant in the skin of psoriasis patients and thought to play a role in breast cancer progression, may help combat symptoms of the skin condition. (Source: MedWire News - Psoriasis)

Updated Guidelines Address Management of Plaque Psoriasis Updated Guidelines Address Management of Plaque Psoriasis

Medscape Today Headlines — Fri, 20 Jan 2012 15:50:14 +0100

The National Psoriasis Foundation Medical Board updated the Canadian Guidelines for the Management of Plaque Psoriasis to include new treatments such as ustekinumab and excimer laser. Medscape Medical News (Source: Medscape Today Headlines)

Early, Aggressive Treatment May Help Reduce Symptoms And Improve Joint Function In Psoriatic Arthritis (PsA)

Health News from Medical News Today — Fri, 20 Jan 2012 09:00:00 +0100

Medications or biologic agents that target T-cells, white blood cells involved in the body's immune system, appear to offer significant benefit to patients suffering from psoriatic arthritis (PsA), a type of arthritis that affects up to 48 percent of patients with the skin disease psoriasis, according to a new review article in the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). About 7.5 million Americans - roughly 2.2 percent of the population - have psoriasis, an autoimmune disease that causes red, flaky skin... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Work disability in psoriatic arthritis: a systematic review

Rheumatology — Fri, 20 Jan 2012 05:00:00 +0100

Conclusions. Disability at work in those with PsA is high; however, data on its associations are limited by the small number of reports and heterogeneity of data collected. Future work should focus on the validation of WD data collection tools for use in PsA. (Source: Rheumatology)

Targeting soluble epoxide hydrolase for inflammation and pain - An overview of pharmacology and the inhibitors.

Inflammation and Allergy Drug Targets — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Pillarisetti S, Khanna I Abstract Chronic inflammation is an important contributing factor to a variety of human diseases including rheumatoid arthritis, inflammatory bowel disease, psoriasis and atherosclerosis. Epoxidation of arachidonic acid by cytochrome P450 enzymes during inflammation yields epoxyeicosatrienoic acids (EETs). EETs have a variety of biological effects including modulation of inflammation, vascular smooth muscle migration and platelet aggregation. The EETs levels are regulated by soluble epoxide hydrolase (sEH), the major enzyme responsible for their degradation and conversion to inactive dihydroxyeicosatrienoic acids (DHETs); thereby limiting many of the biological actions of EETs. The molecular and pharmacological inhibition of sEH has been studied ex...

The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases.

Inflammation and Allergy Drug Targets — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Toussirot E Abstract IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. IL-23 and Th17 correspond to a new axis that drives immune activation and chronic inflammation through the differentiation and activation of Th17 cells. Animal models of chronic inflammatory diseases such as chronic joint diseases, inflammatory bowel diseases and demyelinating diseases strongly suggest the involvement of this cytokine pathway. Thus, IL-23/Th17 is considered as a relevant therapeutic target in autoimmune driven diseases, and biological agents blocking IL-23 or IL-17 are currently being developed. Ustekinumab ...

Interactions between Inflammation and Coagulation in Autoimmune and Immune-Mediated Skin Diseases.

Current Vascular Pharmacology — Fri, 20 Jan 2012 05:00:00 +0100

Authors: Marzano AV, Tedeschi A, Polloni I, Crosti C, Cugno M Abstract Inflammation and coagulation systems are simultaneously activated in autoimmune and immune-mediated skin disorders, and the cross-talk that amplifies and maintains their activation seems to have both local and systemic implications. This interplay occurs in bullous pemphigoid (BP), the prototype autoimmune blistering disease in which eosinophil recruitment and thrombin generation locally contribute to the formation of bullae and inflammatory tissue damage. Moreover, the systemic activation of coagulation may explain the increased thrombotic risk observed in BP patients. Atopic dermatitis (AD), a chronically relapsing immune-mediated inflammatory skin disease, also involves the local and systemic activation of co...

Psoriasin potential target for psoriasis therapy

MedWire News - Dermatology — Fri, 20 Jan 2012 00:00:00 +0100

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan

Modern Rheumatology — Thu, 19 Jan 2012 06:56:48 +0100

Abstract Adalimumab is a monoclonal antibody produced by DNA recombination technology, and is the first human monoclonal antibody against human tumor necrosis factor (TNF)-α in the world. Adalimumab binds with high affinity and specificity to soluble TNF-α and normalizes its biological action. The clinical development of adalimumab started in Europe. Adalimumab was approved for the treatment of rheumatoid arthritis (RA) in December 2002 in the United States and in September 2003 in the European Union. Since then, adalimumab has been approved for the expanded indications of psoriatic arthritis (PsA), ankylosing spondylitis (AS), Crohn’s disease (CD), psoriasis (Ps), and juvenile idiopathic arthritis (JIA) in the United States and the European Union, and it is now used w...

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Blood — Thu, 19 Jan 2012 05:00:00 +0100

Although activity that induced tumor regression was observed and termed tumor necrosis factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when Aggarwal and coworkers reported, for the first time, the isolation of 2 cytotoxic factors: one, derived from macrophages (molecular mass 17 kDa), was named TNF, and the second, derived from lymphocytes (20 kDa), was named lymphotoxin. Because the 2 cytotoxic factors exhibited 50% amino acid sequence homology and bound to the same receptor, they came to be called TNF-α and TNF-β. Identification of the protein sequences led to cloning of their cDNA. Based on sequence homology to TNF-α, now a total of 19 members of the TNF superfamily have been identified, along with 29 interacting receptors, and sev...

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

PLoS Genetics — Thu, 19 Jan 2012 05:00:00 +0100

by Kristina Gervin, Magnus D. Vigeland, Morten Mattingsdal, Martin Hammerø, Heidi Nygård, Anne O. Olsen, Ingunn Brandt, Jennifer R. Harris, Dag E. Undlien, Robert Lyle Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance indicates a role for epigenetic or environmental factors in disease. We used MZ twins discordant for psoriasis to search for genome-wide differences in DNA methylation and gene expression in CD4+ and CD8+ cells using Illumina's HumanMethylation27 and HT-12 expression assays, respectively. Analysis of these data revealed no differentially methylated or expressed genes between co-twins when analyzed separately, although we observed a substantial amount of...

New medication, surgery may offer relief for patients with psoriatic arthritis

EurekAlert! - Medicine and Health — Wed, 18 Jan 2012 05:00:00 +0100

(American Academy of Orthopaedic Surgeons) Medications or biologic agents that target T-cells, white blood cells involved in the body's immune system, appear to offer significant benefit to patients suffering from psoriatic arthritis, a type of arthritis that affects up to 48 percent of patients with the skin disease psoriasis, according to a new review article in the Journal of the American Academy of Orthopaedic Surgeons. (Source: EurekAlert! - Medicine and Health)

Psoriasis phototherapy experience from a Lisbon unit: a still valid therapeutic approach in the 21st century.

Cutaneous and Ocular Toxicology — Wed, 18 Jan 2012 05:00:00 +0100

Discussion: Current advancements in therapeutics enjoyed today include the advent of the biologics and other immunomodulating systemic agents. However, attending to the responses achieved, and considering other variables like well-known side effects and cost, photo(chemo)therapy will remain an essential method of treatment for psoriasis vulgaris in the 21st century. PMID: 22250764 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

LEO, Virobay to develop oral psoriasis drug

Modern Medicine — Wed, 18 Jan 2012 00:35:50 +0100

Denmark-based LEO Pharma has signed an in-licensing deal with the Menlo Park biotech company Virobay to develop an oral treatment for psoriasis. (Source: Modern Medicine)

Biopharmaceuticals and biosimilars in psoriasis: What the dermatologist needs to know

Journal of the American Academy of Dermatology — Tue, 17 Jan 2012 18:08:58 +0100

The entry of biosimilar forms of biopharmaceutical therapies for the treatment of psoriasis and other immune-mediated disorders has provoked considerable interest. Although dermatologists are accustomed to the use of a wide range of generic topical agents, recognition of key differences between original agent (ie, the name brand) and the generic or biosimilar agent is necessary to support optimal therapy management and patient care. In this review we have summarized the current state of the art related to the impending introduction of biosimilars into dermatology. Biosimilars represent important interventions that are less expensive and hence offer the potential to deliver benefit to large numbers of patients who may not currently be able to access these therapies. But the development of b...

Sequential therapy in plaque psoriasis using the “ Hit and Run ” approach: infliximab followed by efalizumab

International Journal of Dermatology — Tue, 17 Jan 2012 17:44:33 +0100

(Source: International Journal of Dermatology)

Quality of life among Malaysian patients with vitiligo

International Journal of Dermatology — Tue, 17 Jan 2012 17:42:55 +0100

Conclusion Patients in our cohort showed a moderate limitation of QoL, comparable to that of other chronic skin diseases. Management should focus not only on medical treatment but also psychological aspects, hence better QoL and treatment outcomes. (Source: International Journal of Dermatology)

Exploring the role of prolactin in psoriasis

Archives of Dermatological Research — Tue, 17 Jan 2012 07:12:28 +0100

Abstract Prolactin (PRL) is well recognised for its role(s) in mammary gland development and function. Moreover, its role in skin biology, including the potent regulation of human hair growth, is becoming clearer. Less widely appreciated, however, is the potential role of PRL in the pathobiology of psoriasis. While the relationship between PRL and psoriasis remains enigmatic, several recent publications on the PRL–psoriasis connection have demonstrated a reawakening of interest in this conundrum. We take the occasion of these reports to underscore the importance of dissecting the role(s) of PRL in the aetiopathology of psoriasis, not least since this may help to identify novel hormonal treatment strategies in its management. Content Type Journal ArticleCategory News ...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Trends in Pediatric Psoriasis Outpatient Health Care Delivery in the United States [Study]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

Conclusions Over the 28-year interval, outpatient visits for pediatric psoriasis were attended primarily by white children older than 8 years in equal number by sex. Dermatologists and pediatricians saw the majority, and treatment approach differed by physician specialty and patient age. Treatment guidelines for childhood psoriasis may help reduce treatment variability. (Source: Archives of Dermatology)

Prescribing Patterns by Dermatologists and Primary Care Providers for Pediatric Psoriasis: Comment on "Trends in Pediatric Psoriasis Outpatient Health Care Delivery in the United States" [Practice Gaps]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

(Source: Archives of Dermatology)

Consensus Guidelines for the Management of Plaque Psoriasis [Consensus Statement]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

The Canadian Guidelines for the Management of Plaque Psoriasis were reviewed by the entire National Psoriasis Foundation Medical Board and updated to include newly approved agents such as ustekinumab and to reflect practice patterns in the United States, where the excimer laser is approved for psoriasis treatment. Management of psoriasis in special populations is discussed. In the updated guidelines, we include sections on children, pregnant patients or pregnant partners of patients, nursing mothers, the elderly, patients with hepatitis B or C virus infections, human immunodeficiency virus–infected patients, and patients with malignant neoplasms, as well as sections on tumor necrosis factor blockers, elective surgery, and vaccinations. (Source: Archives of Dermatology)

Maturation of an Idea: A Historical Perspective on the Association of Psoriasis With the Metabolic Syndrome and Cardiovascular Disease [Notable Notes]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

(Source: Archives of Dermatology)

Prevalence of Monoclonal Gammopathy Among Patients with Psoriatic Arthritis.

J Rheumatol — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: Monoclonal gammopathy occurs in patients with PsA more commonly than in the general population. Its prevalence is associated with measures of disease activity and duration. PMID: 22247355 [PubMed - as supplied by publisher] (Source: J Rheumatol)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Familial Autoimmunity in Systemic Sclerosis - Results of a French-based Case-control Family Study.

J Rheumatol — Sun, 15 Jan 2012 05:00:00 +0100

CONCLUSION: Our results show that autoimmune diseases cluster within families of patients with SSc. This supports the notion that these diseases might arise on a shared genetic basis underlying several autoimmune phenotypes. PMID: 22247345 [PubMed - as supplied by publisher] (Source: J Rheumatol)

Management of Pediatric Psoriasis.

Pediatric Annals — Sat, 14 Jan 2012 14:12:15 +0100

Authors: Bhutani T, Kamangar F, Cordoro KM PMID: 22224488 [PubMed - as supplied by publisher] (Source: Pediatric Annals)

Dermal vasculature in psoriasis and psoriasiform dermatitis: A morphometric study

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion : Our results indicate that vascular tortuousity and dilatation is significant only in psoriatic lesions. These results may assist in automated diagnosis of skin biopsies. (Source: Indian Journal of Dermatology)

Determinants of quality of life in psoriasis patients: A cluster analysis of 50 patients

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusions: On the basis of this study, we would recommend that psoriasis patients especially with severe disease require a more holistic treatment approach that encompasses both medical and psychological measures. (Source: Indian Journal of Dermatology)

Pilot study of sexual dysfunction in patients with psoriasis: Influence of biologic therapy

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion: We considered our series as a first step for a more detailed approach to the study of sexual function in patients with psoriasis. (Source: Indian Journal of Dermatology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Disseminated granuloma annulare: A cutaneous adverse effect of anti-TNF agents

Indian Journal of Dermatology — Sat, 14 Jan 2012 05:00:00 +0100

We describe a 56-year-old woman who developed an erythematous pruritic rash on both arms-diagnosed as granuloma annulare by skin biopsy-approximately 22 months after initiating adalimumab for treatment of rheumatoid arthritis. On stopping adalimumab there was total clearance of the skin lesions, but a similar rash developed again when her treatment was switched to another anti-TNF agent (etanercept). This clinical observation supports a link between TNF inhibition and the development of granuloma annulare. (Source: Indian Journal of Dermatology)

Studies on serum 8‐hydroxy guanosine (8‐OHdG) as reliable biomarker for psoriasis

Journal of the European Academy of Dermatology and Venereology — Sat, 14 Jan 2012 05:00:00 +0100

Conclusion Serum 8‐OHdG levels could be used as good biomarker for the early diagnosis of psoriasis and its management. (Source: Journal of the European Academy of Dermatology and Venereology)

Adalimumab/infliximab: Psoriasis treated with ustekinumab: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Etanercept: Generalised pustular psoriasis treated with ciclosporin: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

(Source: Reactions)

Briakinumab for the Treatment of Plaque Psoriasis

BioDrugs — Fri, 13 Jan 2012 23:22:39 +0100

(Source: BioDrugs)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Psoriasis increases risk for coronary artery disease

MedWire News - Dermatology — Fri, 13 Jan 2012 22:27:54 +0100

Patients with psoriasis undergoing coronary angiography have a higher prevalence of coronary artery disease than those without the condition, say researchers, particularly those with a long duration of the skin disease. (Source: MedWire News - Dermatology)

IL‐17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

Experimental Dermatology — Fri, 13 Jan 2012 22:25:00 +0100

Abstract: Atopic eczema and psoriasis are common skin diseases. While it is well established that the pathogenesis of these diseases varies, both are characterized by impairment in epidermal barrier function and abnormal IL‐17 expression in the skin and peripheral blood. Recent findings indicated that filaggrin is essential during barrier formation and its insufficiency underlies the pathogenesis of atopic eczema. Filaggrin downregulation has also been reported in psoriasis. It is clear that Th1/Th2 bias influences expression of the protein, but an analysis of the effects of interleukin‐17 (IL‐17) on the expression of the protein and profilaggrin‐processing enzymes has not yet been reported. In addition, the effect of the cytokine on components of functional epidermal barrier, t...

Psoriasis

Consultant Live — Fri, 13 Jan 2012 12:00:00 +0100

The one disease in which small nail pits and separation of the nail plate from the nail bed is seen concomitantly is psoriasis. (Source: Consultant Live)

Interferon and Biologic Signatures in Dermatomyositis Skin: Specificity and Heterogeneity across Diseases.

Herpes — Fri, 13 Jan 2012 11:30:16 +0100

CONCLUSIONS AND SIGNIFICANCE: As in the blood and muscle, DM skin is characterized by an overwhelming presence of an IFN signature, although it is difficult to conclusively define this response as type I or type II. Understanding the significance of the IFN signature in this wide array of inflammatory diseases will be furthered by identification of the nature of the cells that both produce and respond to IFN, as well as which IFN subtype is biologically active in each diseased tissue. PMID: 22235269 [PubMed - in process] (Source: Herpes)

A Nonimmunosuppressant Approach on Asia Psoriasis Subjects: 5-Year Followup and 11-Year Data Analysis

Computational Intelligence and Neuroscience — Thu, 12 Jan 2012 11:11:41 +0100

Mono- or combine immunosuppressants are commonly used for psoriasis; however the side effect caused by potent systemic immunosuppressants frequently incurred; moreover the inflammation flares up shortly after immunosuppressants are discontinued. An alternative nonimmunosuppressive therapy was introduced to psoriasis subjects. A retrospective observational study consisted of 1583 psoriasis patients who were treated with Herose Psoria capsule 1440 mg three times daily at two clinical centres, one in China, the other in Singapore, from 1 January 2000 to 1 January 2011. Psoriasis lesion evolution was photographed at monthly visit, and efficacy and safety were assessed using psoriasis area severity index PASI score grading, renal and liver function testing, and adverse event reporting and sup...

A Plan To Effectively Treat Psoriasis

Health News from Medical News Today — Thu, 12 Jan 2012 09:00:00 +0100

About 300 000 Swedes suffer from the difficult to treat disease, which manifests itself in scaly and often itchy patches on the skin. The reason is that cells divide without restraint as new blood vessels form in the deeper layers of the skin. An important component is the psoriasin protein (S100A7), which are abundant in psoriasis-affected skin but rarely in normal skin. The same protein is also assumed to be a factor in the development of breast cancer... (Source: Health News from Medical News Today)

No extra cardiac risk with methotrexate for psoriasis

Modern Medicine — Thu, 12 Jan 2012 05:00:00 +0100

NEW YORK (Reuters Health) - In psoriasis and psoriatic arthritis, methotrexate poses no greater cardiac risks than any other non-biologic anti-psoriatic drug - and it may even attenuate those risks, according to researchers from Taiwan. (Source: Modern Medicine)

Association of Erectile Dysfunction with Atopic Dermatitis: A Population‐Based Case‐Control Study

The Journal of Sexual Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Conclusions. There was an association between ED and prior AD. We suggest that clinicians should be more attentive to sexual complaints from patients with AD. Chung S‐D, Keller JJ, and Lin H‐C. Association of erectile dysfunction with atopic dermatitis: A population‐based case‐control study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients.

The British Journal of Dermatology — Wed, 11 Jan 2012 05:00:00 +0100

Conclusions: Psoriasis and atopic dermatitis thus associate with quantitative and qualitative changes of peripheral NK cells, mostly shared by both diseases, supporting a common process implicating these innate effectors in skin inflammation. PMID: 22233261 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients

British Journal of Dermatology — Wed, 11 Jan 2012 05:00:00 +0100

Heart disease more likely in people with psoriasis: study

Reuters: Health — Wed, 11 Jan 2012 01:53:52 +0100

(Reuters) - People who suffer from psoriasis may want to pay extra attention to heart risks, since they may be at a greater risk for blocked arteries than those who don't have the skin disease -- although the risk increase is not that high, according to a U.S. study. (Source: Reuters: Health)

Heart disease more likely in people with psoriasis

Reuters: Health — Tue, 10 Jan 2012 21:16:05 +0100

NEW YORK (Reuters Health) - People who suffer from psoriasis may want to pay extra attention to heart risks, according to a new study that found they are at a greater risk for blocked arteries than those who don't have the skin disease. (Source: Reuters: Health)

Heart Disease More Likely in People with Psoriasis

MedlinePlus Health News — Tue, 10 Jan 2012 21:15:58 +0100

People who suffer from psoriasis may want to pay extra attention to heart risks, according to a new study that found they are at a greater risk for blocked arteries than those who don't have the skin disease.Source: Reuters Health Related MedlinePlus Pages: Heart Diseases, Psoriasis (Source: MedlinePlus Health News)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Treatment of psoriasis gets new hope

EurekAlert! - Medicine and Health — Tue, 10 Jan 2012 05:00:00 +0100

(Linköping University) Researchers at Linkoeping University in Sweden are now launching a plan to effectively treat psoriasis. The study focuses on the psoriasin protein. (Source: EurekAlert! - Medicine and Health)

A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

BMC Immunology — Tue, 10 Jan 2012 05:00:00 +0100

Conclusions: SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist. It is efficacious in multiple preclinical disease models. These results demonstrate that therapy with CXCR3 antagonists may serve as a new strategy for treatment of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, and to prevent transplant rejection. (Source: BMC Immunology)

Psoriasiform pemphigus foliaceus: a report of two cases.

Journal of Cutaneous Pathology — Tue, 10 Jan 2012 05:00:00 +0100

We present two patients with a previous diagnosis of psoriasis who presented to our dermatology department with an exfoliative erythroderma, which ultimately proved to be due to PF based on histopathological features, direct immunofluorescence results, and levels of antibodies against desmoglein 1. Both patients responded well to oral prednisone and rituximab. This variant of PF should be entertained in both the clinical differential diagnosis of psoriasiform erythroderma and in the microscopic differential diagnosis of psoriasiform epidermal hyperplasia with focal acantholysis, particularly in patients for whom the clinical history is not classic for psoriasis or for whom conventional psoriasis therapies have not proven beneficial. (Source: Journal of Cutaneous Pathology)

Phosphospecific flow cytometry for pharmacodynamic drug monitoring: Analysis of the JAK-STAT signaling pathway.

International Journal of Clinical Chemistry — Tue, 10 Jan 2012 05:00:00 +0100

Authors: Vafadari R, Weimar W, Baan CC Abstract Cytokines of the IL-2 receptor family act via activation of the JAK-STAT (janus tyrosine kinase-signal transducer and activator of transcription) signaling pathway. These cytokines are pivotal for the development and function of lymphocyte subsets involved in immune response after organ transplantation including T, B and natural killer cells. The new small drug molecule and JAK1/3 inhibitor, tofacitinib, is currently being tested in phase II and III clinical trials for rheumatoid arthritis, psoriasis and in organ transplantation. This agent specifically targets the JAK-STAT signaling pathway. Here we discuss phosphospecific flow cytometry as a novel tool to monitor the JAK-STAT signaling pathway in kidney transplant patients and specu...

Opinion of Spanish Dermatologists Regarding the Use of Biologic Therapy in Patients With Moderate to Severe Psoriasis.

Actas Dermo-Sifiliograficas — Tue, 10 Jan 2012 05:00:00 +0100

CONCLUSIONS: Dermatologists with experience in the use of biologic drugs employ this treatment option in slightly more than a quarter of cases of moderate to severe psoriasis. In their opinion, the choice of biologic drug should be based on, in order of importance, safety, long-term efficacy, and tolerance. PMID: 22240159 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity

Clinical Reviews in Allergy and Immunology — Mon, 09 Jan 2012 19:36:56 +0100

Abstract In relapsing remitting multiple sclerosis (RRMS), type I interferon (IFN) is considered immuno-modulatory, and recombinant forms of IFN-β are the most prescribed treatment for this disease. However, within the RRMS population, 30–50% of MS patients are nonresponsive to this treatment, and it consistently worsens neuromyelitis optica (NMO), a disease once considered to be a form of RRMS. In contrast to RRMS, type I IFNs have been shown to have properties that drive the inflammatory pathologies in many other autoimmune diseases. These diseases include Sjögren's syndrome, system lupus erythematosus (SLE), neuromyelitis optica (NMO), rheumatoid arthritis (RA) and psoriasis. Historically, autoimmune diseases were thought to be driven by a TH1 response to auto-antig...

Comparison of Skindex-29, Dermatology Life Quality Index (DLQI), Psoriasis Disability Index (PDI) and Medical Outcome Study Short Form (SF-36) in patients with mild to severe psoriasis.

The British Journal of Dermatology — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion: Skindex has better sensitivity to clinical severity with minimal floor effect, and cover the main domains explored by the other 3 QoL instruments in patients with mild to severe psoriasis. PMID: 22229951 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Comparison of Skindex‐29, Dermatology Life Quality Index (DLQI), Psoriasis Disability Index (PDI) and Medical Outcome Study Short Form (SF‐36) in patients with mild to severe psoriasis.

British Journal of Dermatology — Mon, 09 Jan 2012 05:00:00 +0100

Psoriasis may increase the risk for diabetes

MedWire News - Psoriasis — Sun, 08 Jan 2012 17:29:00 +0100

Results from a systematic review and meta-analysis indicate that psoriasis is a risk factor for diabetes. (Source: MedWire News - Psoriasis)

Pilot study on the acceptance of mobile teledermatology for the home monitoring of high‐need patients with psoriasis

Australasian Journal of Dermatology — Fri, 06 Jan 2012 05:00:00 +0100

Conclusion: Mobile teledermatology is a valuable tool for the home monitoring of patients with psoriasis that makes a meaningful difference in their lives. It is well accepted by both patients and the physicians involved. (Source: Australasian Journal of Dermatology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Improvement of psoriasis during exenatide treatment in a patient with diabetes.

Diabetes and Metabolism — Fri, 06 Jan 2012 05:00:00 +0100

CONCLUSION: There was a major and rapid improvement in psoriasis in our patient with T2D following treatment with exenatide. A possible mechanism might be through direct modulation of the immune system by GLP-1 receptor agonists. PMID: 22227407 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)

Psoriasis may increase the risk for diabetes

MedWire News - Dermatology — Fri, 06 Jan 2012 00:00:00 +0100

Results from a systematic review and meta-analysis indicate that psoriasis is a risk factor for diabetes. (Source: MedWire News - Dermatology)

Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study.

Nutrition Journal — Thu, 05 Jan 2012 05:00:00 +0100

Conclusions: Our results indicate that there was no significant association between the MTHFR gene polymorphism and psoriasis vulgaris in the Malaysian population. There was no significant increase of the plasma homocysteine level in the psoriasis patients compared to the controls. (Source: Nutrition Journal)

PSORIASIS CONTROL (Centella Asiatica, Sodium Chloride, And Silicon Dioxide) Solution/ Drops [Forces Of Nature]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 05 Jan 2012 05:00:00 +0100

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A comparative study of hair shafts in scalp psoriasis and seborrheic dermatitis using atomic force microscopy

Skin Research and Technology — Wed, 04 Jan 2012 05:00:00 +0100

ConclusionThe differences in hair shafts between SP and SD were investigated noninvasively using AFM. The presence of macropits could be helpful in the differentiation between SP and SD. (Source: Skin Research and Technology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

[HIV infection.]

Herpes — Wed, 04 Jan 2012 05:00:00 +0100

Authors: Potthoff A, Rasokat H, Brockmeyer NH Abstract The skin can be an indicator of decreased immunocompetence. Dermatological markers include new and extensive seborrheic eczema, psoriasis without a family history, widespread herpes zoster in young adults, oral hairy leucoplakia and mollusca in adults. In these cases an HIV test should be offered. During the last 15 years the clinical picture of HIV has changed dramatically. Almost every year new drugs with better efficacy, lower pill burden and less side effects have been approved. Life expectancy is close to normal in western countries. In spite of better treatment options, prevention is the key to stop the worldwide epidemic. Awareness campaigns have to account for the synergies between HIV and other sexually transmitted di...

Psoriasis patients must be assessed for comorbidity risk

HealthcareRepublic Pharmacist News — Tue, 03 Jan 2012 09:52:00 +0100

Patients with psoriasis are more likely to have a wide range of other conditions for which they should be assessed and treated, a study has shown. (Source: HealthcareRepublic Pharmacist News)

Outcomes Associated with Matching Patients' Treatment Preferences to Physicians' Recommendations: Study Methodology

BMC Health Services Research — Tue, 03 Jan 2012 05:00:00 +0100

We describe the methodology used in a study aiming to assess treatment outcomes when patients' preferences for treatment are closely matched to recommended treatments.MethodParticipants included patients with moderate or severe psoriasis attending outpatient dermatology clinics at the University Medical Centre Mannheim, University of Heidelberg, Germany. A self-administered online survey used conjoint analysis to measure participants' preferences for psoriasis treatment options at the initial study visit. Physicians' treatment recommendations were abstracted from each participant's medical records. The Preference Matching Index (PMI), a measure of concordance between the participant's preferences for treatment and the physician's recommended treatment, was determined for each participant a...

[Psoriasis in infants about five cases.]

Archives de Pediatrie — Tue, 03 Jan 2012 05:00:00 +0100

CONCLUSION: Psoriasis is a multifactorial disease complex, multiple mechanisms, not well known, with combination of genetic, immunological and environmental factors. Treatment is in the light with corticosteroids, anti-inflammatory and immunomodulators obtained by genetic engineering techniques raises considerable hope in severe forms. PMID: 22221500 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Jan 2012 05:00:00 +0100

Conclusion Our study points to the possible role played by OPN in the pathogenesis of psoriasis and in reflecting disease severity. These standard therapeutic modalities used in the current study were associated with a significant decrease in PASI and OPN levels. They constitute highly effective therapeutic modalities for psoriasis, which might exert their anti‐psoriatic activity partially through altering the expression of OPN. (Source: Journal of the European Academy of Dermatology and Venereology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Narrowband ultraviolet B and biologics in psoriasis.

The British Journal of Dermatology — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Calzavara-Pinton P PMID: 22212055 [PubMed - in process] (Source: The British Journal of Dermatology)

Combination biologic treatment of refractory psoriasis and psoriatic arthritis.

J Rheumatol — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Cuchacovich R, Garcia-Valladares I, Espinoza LR PMID: 22210681 [PubMed - in process] (Source: J Rheumatol)

Patient preferences for psoriasis treatments: impact of treatment experience

Journal of the European Academy of Dermatology and Venereology — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions Treatment preferences may change over time course and with treatment experience. Participants on injectables attach great importance to efficiency and convenience of therapies, and are highly satisfied with their treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

[Extensive Dowling-Degos disease following long term PUVA therapy].

Annales de Dermatologie et de Cenereologie — Sun, 01 Jan 2012 05:00:00 +0100

DISCUSSION: Dowling-Degos disease is a reticulate pigmentary disorder of the flexures associating prominent comedone-like lesions and pitted scars. Diagnosis is based on clinical and histopathological examination, which allows this entity to be differentiated from other reticulate pigmentary disorders. A literature review failed to provide any indication that PUVA therapy either aggravates or reveals Dowling-Degos disease, a finding which we feel merits mention. PMID: 22225744 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

Induction of GITRL Expression in Human Keratinocytes by TH2 cytokines and TNFα: Implications for Atopic Dermatitis

Clinical and Experimental Allergy — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions and Clinical Relevance:Our studies demonstrate that GITRL expression is augmented by Th2 cytokines and TNFα in keratinocytes. Increased GITRL expession in acute AD skin lesions is shown. This data suggests a link between cytokine regulated keratinocyte GITRL expression and its role in inflammatory responses in AD.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy)

MedWorm Sponsor Message: Find the best January Sales in the UK.

The malassezia genus in skin and systemic diseases.

Clinical Microbiology Reviews — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A Abstract Summary: In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. restricta, and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis, M. japonica, M. yamatoensis, M. nana, M. caprae, M. equina, and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species...

The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data

Journal of the European Academy of Dermatology and Venereology — Sun, 01 Jan 2012 05:00:00 +0100

AbstractTwins have always fascinated medical research even before the discovery of DNA and the understanding of the differences between identical and non‐identical twins. Dermatology with the benefit of being able to visualize phenotypes was one of the first specialities reporting on the fascinating concordance in identical (MZ) twins in the 1920’s. Over the last 20 years, the heritability of skin diseases using twins has been clearly demonstrated, across a wide variety of traits including melanoma, polymorphic light eruption, psoriasis, eczema and acne. Other rarer diseases have also been shown to have a significant genetic basis such as lupus, sarcoidosis and lichen sclerosus. Following evidence of heritability for many skin disease the next step was Genome‐Wide Association Studi...

Prevalence and factors associated with uveitis in spondyloarthropathies patients in France: Results from the EXTRA observational survey

Arthritis Care and Research — Sun, 01 Jan 2012 05:00:00 +0100

Conclusion:Results indicate that uveitis is the most common extra‐articular feature of SpAs and that it occurs preferentially in HLA‐B27 positive patients and over all the course of the disease. (Source: Arthritis Care and Research)

[Diagnosis and therapy of early psoriatic arthritis].

Zeitschrift fur Rheumatologie — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Köhm M, Behrens F Abstract Early diagnosis of psoriatic arthritis is of importance because an erosive disease is already detectable after a 2-year duration of symptoms. Often psoriatic arthritis cannot easily be detected because of the diversity of disease manifestations in early stages. As up to 30% of psoriasis patients develop psoriatic arthritis an interdisciplinary dermatologic/rheumatologic approach to diagnose findings and treatment decisions would be desirable. Screening tools, such as validated questionnaires allow an early detection and selection of patients with a high probability of psoriatic arthritis even in dermatological care or on a house physician basis. The implementation of the CASPAR criteria as a classification tool for psoriatic arthritis has also i...

Comorbid Psoriasis Adds Hefty Economic Burden

Clinical Endocrinology News — Sun, 01 Jan 2012 05:00:00 +0100

LISBON – Psoriasis and diabetes are expensive diseases, and patients with both conditions experience a synergistic increase in health care utilization and costs that is significantly greater than the incremental economic burden imposed by each disease individually. (Source: Clinical Endocrinology News)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Psoriasis increased the risk of diabetes: a meta-analysis

Archives of Dermatological Research — Sat, 31 Dec 2011 16:48:40 +0100

Abstract To evaluate the association between psoriasis and risk of diabetes, pertinent studies were identified by searching electronic databases and by reviewing the reference lists of retrieved articles. We included observational studies that examined the association between psoriasis and risk of diabetes. Two reviewers independently assessed eligibility and used a standardized form to collect data from published studies. The study quality was assessed by the Newcastle–Ottawa Scale. A total of 22 eligible studies that included 3,307,516 participants fulfilled the inclusion criteria. Compared to individuals without psoriasis, subjects with psoriasis had a 1.42-fold increased risk of diabetes (95% CI, 1.40–1.45). Findings from this meta-analysis suggest that individuals...

Kaposi Sarkom bei einem Patienten mit Psoriasis

JDDG — Sat, 31 Dec 2011 05:41:49 +0100

(Source: JDDG)

Thy-1 (CD90) Is an Interacting Partner for CD97 on Activated Endothelial Cells.

Journal of Immunology — Fri, 30 Dec 2011 05:00:00 +0100

In this study, we characterized the adhesion G-protein coupled receptor CD97, present on peripheral myeloid cells, as a novel interacting partner for Thy-1. CD97 was upregulated on polymorphonuclear cells (PMNC) of patients with psoriasis. In psoriatic skin lesions, CD97(+) myeloid cells colocalized with Thy-1(+) EC of small vessels in microabscesses, suggesting an interaction between CD97 and Thy-1 that was further examined by adhesion and protein-binding assays. PMNC and cell lines stably overexpressing CD97 adhered specifically to Thy-1(+)-activated human dermal EC, Thy-1(+) CHO cells, and immobilized Thy-1 protein. Binding of the CD97(+) CHO clones correlated with their CD97 expression level. Soluble CD97 bound specifically to immobilized Thy-1 protein, as well as Thy-1(+)-activated EC...

Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: An analysis of Japanese clinical trials of infliximab

The Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

AbstractEuropean S3 Guidelines on the systemic treatment of psoriasis in 2009 propose 75% or more improvement in the Psoriasis Area and Severity Index from baseline (PASI 75) and a Dermatology Life Quality Index (DLQI) of 0 or 1 as treatment goals. However, the relationship of these two parameters is yet to be clarified. Herein, we analyzed the data pooled from two Japanese phase III clinical trials on psoriasis with infliximab to clarify the PASI response necessary to achieve a DLQI of 0 or 1. Of the 90 patients, the mean percent improvement in PASI at week 50 or 66 was 74.5%, and the PASI 75 and PASI 90 response rates were 66.7% and 46.7%, respectively; no difference in the improvement was noted among the body areas. Significant improvements in nail psoriasis were also observed. A negati...

Epidemiology and clinical features of pediatric psoriasis in tertiary referral psoriasis clinic

The Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

In conclusion, our patients showed distinctive features in clinical phenotypes, disease severity and affected body parts compared with previous reports. We also found that clinical application of systemic therapies were limited considering the severe disease state of our patients, demanding a need for more research on treatment of pediatric psoriasis. (Source: The Journal of Dermatology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

The use of methotrexate in dermatology: a review

Australasian Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

ABSTRACTMethotrexate is a synthetic folic acid analogue valued for both its anti‐proliferative and anti‐inflammatory properties. Considered one of the original immune‐modifying agents, it is used widely for the treatment of steroid‐recalcitrant inflammatory diseases. While there are abundant studies documenting its efficacy in rheumatic diseases, the use of methotrexate for dermatological conditions, with the exception of psoriasis, has yet to be comprehensively explored. This two‐part review firstly outlines current data concerning the pharmacology of methotrexate, including its mechanism of action, side‐effect profile and recommended therapeutic approach, and, secondly, examines the emerging evidence for methotrexate's efficacy in a wide range of cutaneous disorders. (Source:...

Can Trimetazidine, Vinpocetine or Isosorbide Dinitrate Ameliorate Cyclosporine-Induced Nephrotoxicity in Rats?

Journal of Pakistan Medical Students — Thu, 29 Dec 2011 05:00:00 +0100

CONCLUSION: The current study demonstrates that isosorbide dinitrate at the dose of 3.6mg/kg could protect against CsA-induced nephrotoxicity, whereas both trimetazidine and vinpocetine are of unclear utility. Key Words: Cyclosporine; Nephrotoxicity; Trimetazidine; Vinpocetine; Isosorbide Introduction Cyclosporine A (CsA) is a potent antifungal and immunosuppressive compound. It was approved in early 1980s for use as prophylactic antirejection therapy in patients receiving allogeneic transplants (kidney, liver, and heart). It has markedly improved survival of solid organ transplants as compared to conventional therapy consisting of prednisone and azathioprine (from 50% to 85%). In addition, CsA has also been used in the treatment of autoimmune diseases such as psoriasis, rheu...

Association of systemic psoriasis therapies and incidence of myocardial infarction: reply from authors

British Journal of Dermatology — Wed, 28 Dec 2011 09:00:59 +0100

(Source: British Journal of Dermatology)

Correlation between lipoprotein(a) and lipid peroxidation in psoriasis: role of the enzyme paraoxonase‐1

British Journal of Dermatology — Wed, 28 Dec 2011 09:00:36 +0100

Conclusions Our results provide further evidence that oxidative stress and impairment of the antioxidant system in the plasma of patients may play a role in pathogenesis and progression of psoriasis and related complications. (Source: British Journal of Dermatology)

Treatment with 311‐nm ultraviolet B enhanced response of psoriatic lesions in ustekinumab‐treated patients: a randomized intraindividual trial

British Journal of Dermatology — Wed, 28 Dec 2011 09:00:23 +0100

Conclusions Treatment with 311‐nm UVB accelerates the clearance of psoriatic lesions in ustekinumab‐treated patients. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Narrowband ultraviolet B and biologics in psoriasis

British Journal of Dermatology — Wed, 28 Dec 2011 08:59:45 +0100

(Source: British Journal of Dermatology)

Gender characterization in a large series of Brazilian patients with spondyloarthritis

Clinical Rheumatology — Wed, 28 Dec 2011 06:52:23 +0100

Abstract An increasing number of women have been diagnosed with spondyloarthritis (SpA) in recent decades. While a few studies have analyzed gender as a prognostic factor of the disease, no studies have addressed this matter with a large number of patients in South America, which is a peculiar region due to its genetic heterogeneity. The aim of the present study was to analyze the influence of gender on disease patterns in a large cohort of Brazilian patients with SpA. A prospective study was carried out involving 1,505 patients [1,090 males (72.4%) and 415 females (27.6%)] classified as SpA according to the European Spondyloarthropaties Study Group criteria who attended at 29 reference centers for rheumatology in Brazil. Clinical and demographic variables were recorded an...

Core beliefs and psychological distress in patients with psoriasis and atopic eczema attending secondary care: The role of schemas in chronic skin disease

British Journal of Dermatology — Wed, 28 Dec 2011 05:00:00 +0100

Conclusions: The findings have important theoretical and clinical implications for psychological management of patients with psoriasis and eczema. Treatment protocols may benefit by targeting schemas. Further studies are needed to investigate the benefits of schema‐focused therapy in patients with skin disease. (Source: British Journal of Dermatology)

Successful treatment of systemic cold contact urticaria with Etanercept in a patient with psoriasis.

British Journal of Dermatology — Wed, 28 Dec 2011 05:00:00 +0100

(Source: British Journal of Dermatology)

The association between smoking and the development of psoriatic arthritis among psoriasis patients

Annals of the Rheumatic Diseases — Wed, 28 Dec 2011 05:00:00 +0100

Conclusion Smoking may be inversely associated with PsA among psoriasis patients. This association is not present among HLA-C*06-positive individuals. (Source: Annals of the Rheumatic Diseases)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Investigation of IL1, VEGF, PPARG and MEFV genes in psoriatic arthritis susceptibility

Annals of the Rheumatic Diseases — Wed, 28 Dec 2011 05:00:00 +0100

Psoriatic arthritis (PsA) is characterised by joint inflammation in patients with psoriasis or a family history of psoriasis. A study of the Icelandic genealogical database supports a strong genetic component with a 40-fold increased risk of disease in first-degree relatives of patients with PsA.1 In order to identify genes that predispose to disease, two study designs have become prominent in recent years: the candidate gene and the genome-wide association (GWA) approach, using case-control cohorts. Although GWA studies allow a comprehensive analysis of the genome for susceptibility variants, they remain expensive and only three GWAs in PsA have been published to date.2–4 These have identified the HLA C, IL23R, IL12B, IL13 and TRAF3IP2 genes as being robustly associated with PsA. Du...

Successful treatment of systemic cold contact urticaria with Etanercept in a patient with psoriasis.

The British Journal of Dermatology — Wed, 28 Dec 2011 05:00:00 +0100

Authors: Gualdi G, Monari P, Rossi M, Crotti S, Calzavara-Pinton P PMID: 22212112 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Core beliefs and psychological distress in patients with psoriasis and atopic eczema attending secondary care: The role of schemas in chronic skin disease.

The British Journal of Dermatology — Wed, 28 Dec 2011 05:00:00 +0100

Conclusions: The findings have important theoretical and clinical implications for psychological management of patients with psoriasis and eczema. Treatment protocols may benefit by targeting schemas. Further studies are needed to investigate the benefits of schema-focused therapy in patients with skin disease. PMID: 22211355 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis.

Genetics and Molecular Research — Wed, 28 Dec 2011 02:00:11 +0100

In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis. PMID: 22194166 [PubMed - in process] (Source: Genetics and Molecular Research)

Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease.

Molecular Biology Reports — Tue, 27 Dec 2011 05:00:00 +0100

Authors: Lee YH, Choi SJ, Ji JD, Song GG Abstract The aim of this study was to identify candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP → gene → pathway hypothesis. A psoriasis genome-wide association study (GWAS) dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of European descent and a BD GWAS dataset that contained 310,324 SNPs in 1,215 BD cases and 1,278 controls were used in this study. Identify candidate causal SNPs and pathways (ICSNPathway) analysis was applied to the GWAS datasets. ICSNPathway analysis identified 15 candidate causal SNPs and 28 candidate causal pathways. The top five candidate causal SNPs were rs1063478 (P = 1.45E-1...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Sex differences and genomics in autoimmune diseases.

Journal of Autoimmunity — Mon, 26 Dec 2011 05:00:00 +0100

Authors: Amur S, Parekh A, Mummaneni P Abstract Autoimmune diseases (AIDs) are believed to be multifactorial diseases that commonly involve multiple organ systems. About three fourth of the patients afflicted with AIDs are women suggesting that sex differences impact the incidence of AID. However, the proportion of females to males suffering from AID varies depending on the disease. The response to some AID therapeutics also differs in females versus males, suggesting that enrollment of adequate numbers of women and men is important in clinical trials for development of AID drugs. It is known for a long time that genetic factors are important contributors to AID susceptibility. Currently available information suggests that multiple genes with modest association to AID contribute to...

SNP typing accurately discriminates HLA-Cw*06:02 in psoriasis patients

MedWire News - Psoriasis — Sun, 25 Dec 2011 06:05:18 +0100

Researchers have developed a new technique for genotyping the main candidate gene HLA-C in patients with psoriasis, which allows discrimination of homozygotes and heterozygotes through typing of four single nucleotide polymorphisms. (Source: MedWire News - Psoriasis)

Antistreptococcal interventions for guttate and chronic plaque psoriasis: a summarised Cochrane review

Clinical And Experimental Dermatology — Sat, 24 Dec 2011 22:42:57 +0100

(Source: Clinical And Experimental Dermatology)

Combination therapy seems best for relief of psoriasis: report

Modern Medicine — Sat, 24 Dec 2011 05:00:00 +0100

NEW YORK (Reuters Health) - To combat psoriasis, a combination of topical therapies seems to work better than topical monotherapy, according to results of a systematic review and meta-analysis. (Source: Modern Medicine)

Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20–IL-20R1–IL-20R2 complex

Acta Crystallographica Section F — Sat, 24 Dec 2011 05:00:00 +0100

In this report, crystals of the IL-20–IL-20R1–IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P41212 or P43212, with unit-cell parameters a = 111, c = 135 Å, and diffracted X-rays to 3 Å resolution. The crystallographic asymmetric unit contains one IL-20–IL-20R1–IL-20R2 complex, corresponding to a solvent content of approximately 54%. (Source: Acta Crystallographica Section F)

MedWorm Sponsor Message: Find the best January Sales in the UK.

A Review of the Use of the Dermatology Life Quality Index as a Criterion in Clinical Guidelines and Health Technology Assessments in Psoriasis and Chronic Hand Eczema

Dermatologic Clinics — Fri, 23 Dec 2011 05:00:00 +0100

The Dermatology Life Quality Index (DLQI) is an easy and practical way of quantifying the impact of skin disease. The role of DLQI in treatment guidelines and its emergence as an eligibility and response criterion in health technology appraisal are discussed. This review analyzes the current available literature on the clinical use of the DLQI, with particular reference to its relationship with disease severity and as a criterion in the assessment of health technology. The need for future studies of chronic hand eczema to incorporate DLQI to document quality-of-life outcomes with new treatments is also discussed. (Source: Dermatologic Clinics)

SNP typing accurately discriminates HLA-Cw*06:02 in psoriasis patients

MedWire News - Dermatology — Fri, 23 Dec 2011 00:00:00 +0100

Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis

International Journal of Biomedical Imaging — Thu, 22 Dec 2011 21:21:03 +0100

Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer. Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically. Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8. Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity. IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophil...

Erythroid Disturbances Before and After Treatment of Portuguese Psoriasis Vulgaris Patients: A Cross-Sectional and Longitudinal Study

American Journal of Clinical Dermatology — Thu, 22 Dec 2011 06:03:30 +0100

(Source: American Journal of Clinical Dermatology)

8‐methoxypsoralen plus UVA treatment increases the proportion of CLA+CD25+CD4+ T cells in lymph nodes of K5.hTGFβ1 transgenic mice

Experimental Dermatology — Thu, 22 Dec 2011 06:00:18 +0100

Abstract8‐methoxypsoralen plus UVA (PUVA) photochemotherapy is an effective treatment for many skin diseases including psoriasis. However, its exact mechanism of therapeutic action is incompletely understood. Previously, in K5.hTGFβ1 transgenic psoriatic mice, we found that PUVA induces Foxp3+CD25+CD4+ regulatory T cells in both lymph node and spleen. Now, in the same model, we investigated whether cutaneous lymphocyte‐associated antigen (CLA) mediates PUVA’s effect on homing of CD25+CD4+ T cells to the lymph nodes of K5.hTGFβ1 transgenic mice. We found that a low dose of topical PUVA maximally increased the proportion of CLA+CD25+CD4+ T cells in the lymph nodes by up to 8‐fold. We also observed an increased number of Foxp3+CD25+ T cells in the skin of the mice after PUVA treatme...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Clinical study of psoriasis occurring over the age of 60 years: is elderly‐onset psoriasis a distinct subtype?

International Journal of Dermatology — Thu, 22 Dec 2011 05:56:12 +0100

Conclusion The elderly‐onset group demonstrated milder disease courses and some changes in clinical phenotypes and body part of origin compared with early‐ and middle age‐onset groups. Therefore, it seems that patients whose onset of psoriasis was over the age of 60 years might have distinct clinical features in some clinical aspects. (Source: International Journal of Dermatology)

Psoriasis, a model of dermatologic psychosomatic disease: psychiatric implications and treatments

International Journal of Dermatology — Thu, 22 Dec 2011 05:56:00 +0100

AbstractPsoriasis is a common dermatologic disorder with psychiatric comorbidity that often goes undetected and untreated. Psoriasis has higher associations with psychiatric illness than do other dermatologic conditions. We conducted a comprehensive qualitative review of all published medical literature on psoriasis and psychiatric comorbidities since 2005. We found that psoriasis patients suffer psychiatric and psychosocial morbidity that is not commensurate with the extent of cutaneous lesions. Biologic therapies and nonpharmacologic psychosocial interventions show promise in treating comorbid psychiatric illness. The main limitations of this review are the low quality of published studies and the infrequent use of basic science endpoints in reporting treatment outcomes. The literature e...

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

Breast Cancer Research and Treatment — Wed, 21 Dec 2011 20:04:56 +0100

Abstract Psoriasin (S100A7), originally identified in psoriasis, is a calcium-binding protein belonging to the multigenic S100 family. In high-grade ductal carcinoma in situ, psoriasin was identified as one of the most abundant transcripts. We have previously shown that psoriasin was induced by reactive oxygen species (ROS). Moreover, the downregulation of psoriasin by short hairpin RNA (shRNA) led to the reduced expression of vascular endothelial growth factor (VEGF) and inhibited tumor growth in vivo. The aim of the present study was to investigate whether psoriasin could have direct effects on endothelial cells. In this study we demonstrated that psoriasin increased VEGF expression in mammary epithelial cells. The treatment of endothelial cells with recombinant psoriasi...

Patient‐reported outcomes in moderate‐to‐severe plaque psoriasis with scalp involvement: results from a randomized, double‐blind, placebo‐controlled study of etanercept

Journal of the European Academy of Dermatology and Venereology — Wed, 21 Dec 2011 05:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)