MedWorm: Psoriasis

Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Pediatrics — Sat, 21 Nov 2009 14:53:38 +0100

Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Pediatrics)

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Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Dermatology — Sat, 21 Nov 2009 14:00:17 +0100

An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population.

Scandinavian Journal of Rheumatology — Sat, 21 Nov 2009 13:00:02 +0100

Conclusions: The survey questionnaire for SpA in this study is useful for axial SpA screening in China. In southern China, the prevalence of LBP is 7.21%. The prevalence of axial SpA is 0.782%. USpA is the most common subtype of SpA, followed by AS. PMID: 19922021 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)

Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV Trial

Archives of Drug Information — Sat, 21 Nov 2009 00:00:00 +0100

This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 weeks of treatment. Efalizumab showed promising efficacy in the treatment of nail, scalp and palmoplantar psoriasis, which was reflected in improvements in quality of lif...

Videodermatoscopy enhances diagnostic capability in psoriatic balanitis

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: Balanitis is an inflammatory condition of the glans penis that may be caused by a wide range of dermatologic conditions, including psoriasis. Psoriatic balanitis is clinically characterized by erythematous, nonscaling plaques most commonly located proximally on the glans and under the prepuce. Most often, genital psoriasis is part of a more generalized disease process, but in the case of exclusively penile involvement, the correct diagnosis may be difficult to make, and several investigations, including a skin biopsy, are often necessary. (Source: Journal of the American Academy of Dermatology)

Pain associated with aminolevulinic acid-photodynamic therapy of skin disease

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Conclusion: Gamma-aminobutyric acid receptors, cold/menthol receptors (transient receptor potential cation channel, subfamily M, member 8), and vanilloid/capsaicin receptors (transient receptor potential cation channel, subfamily V, member 1) may be involved in pain perception during ALA-PDT and are therefore worthy of further investigation. (Source: Journal of the American Academy of Dermatology)

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Correction

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Patel RV, Clark LN, Lebwohl M, Weinberg JM. Treatments for psoriasis and the risk of malignancy. J Am Acad Dermatol 2009;60:1001-17. On page 1002 of the article above, the following statement was incorrect: Patients with mild psoriasis have a relative risk of 1.42 and 3.18 of developing Hodgkin's lymphoma and CTCL, respectively. Patients with severe psoriasis have a relative risk of 4.10 and 10.75 of developing Hodgkin's lymphoma and CTCL, respectively. (Source: Journal of the American Academy of Dermatology)

Cells That Control Inflammation In Chronic Disease

Health News from Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: Health News from Medical News Today)

Cells That Control Inflammation In Chronic Disease

Immune System / Vaccines News From Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of life

Clinical And Experimental Dermatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions. Our results verify the therapeutic effect of methotrexate for the management of psoriasis. Despite widespread belief and use of TCM in Asia for the treatment of psoriasis, we were unable to confirm the efficacy of TCM in this study. (Source: Clinical And Experimental Dermatology)

Estimation of cost-of-illness in patients with psoriasis in Switzerland.

Swiss Medical Weekly — Thu, 19 Nov 2009 00:00:00 +0100

CONCLUSIONS: Moderate-to-severe psoriasis is associated with a significant impact on the quality of life and at least 4-fold higher costs than mild psoriasis, indicating the need for efficient control of the disease. This cost-of-illness study provides specific health economic data for future healthcare decision making, particularly with the advent of new therapeutic agents for effective psoriasis control. PMID: 19924580 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)

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Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical Trials

Dermatology — Wed, 18 Nov 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000260371) (Source: Dermatology)

Basilea's Toctino(R) Receives Marketing Authorization In Canada

Health News from Medical News Today — Wed, 18 Nov 2009 17:00:00 +0100

Basilea's Toctino(R) Receives Marketing Authorization In Canada

Dermatology News From Medical News Today — Wed, 18 Nov 2009 17:00:00 +0100

Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. "We are delighted that Health Canada has approved the use of Toctino for patients with severe chronic hand eczema unresponsive to potent topical steroids. (Source: Dermatology News From Medical News Today)

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of Psoriasis

Health News from Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

Beginning Thursday, Nov. 19, 2009, the International Psoriasis Council (IPC) will host its second symposium at Baylor University Medical Center in Dallas. The two-day conference brings together dermatologists from Asia, Eastern Europe and Spain to elevate the global understanding of psoriasis and its treatment. (Source: Health News from Medical News Today)

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of Psoriasis

Dermatology News From Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

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[Atopic Dermatitis and Psoriasis: What is the Benefit of In-Patient High Altitude Climate Therapy?]

Praxis — Wed, 18 Nov 2009 00:00:00 +0100

Authors: Steiner C Atopic dermatitis as well as psoriasis are characterized as common, chronic, often long lasting disorders of the cutis. In case of (a) a refractory out-patient therapy, (b) an acute severe exacerbation of skin lesions, (c) functional impairment of hands and feet, (d) suberythroderma or erythroderma, (e) complex topical as well as systemic treatment modalities, (f) complicating somatic or psychological co-morbidity, a referral to in-patient treatment at high altitude must be considered. The therapy at the Hochgebirgsklinik Davos (1'560 m above see level) is characterized by application of natural-borne UV radiation all year round, missing house dust mite allergen, massive reduction of pollens and mycotic spores, improvement of skin perfusion as well as a reduction in ...

Epidemiology and comorbidity of psoriasis in children.

The British Journal of Dermatology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion: Psoriasis is a common disease in children. Like in adults, it is associated with significant comorbidity. Increased attention should be paid to the early detection and treatment of patients affected. PMID: 19922529 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Psoriasis and alcohol: is cutaneous ethanol one of the missing links?

The British Journal of Dermatology — Wed, 18 Nov 2009 00:00:00 +0100

Authors: Farkas A, Kemény L Abstract Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites acetone induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin,...

Scientists discover cells that control inflammation in chronic disease

EurekAlert! - Medicine and Health — Tue, 17 Nov 2009 05:00:00 +0100

(Imperial College London) A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: EurekAlert! - Medicine and Health)

Scientists discover cells that control inflammation in chronic disease

Imperial College News — Tue, 17 Nov 2009 00:00:00 +0100

New kind of immune cell can go out of control in diseases like psoriasis and asthma - News Release (Source: Imperial College News)

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Linking Publication About Efalizumab Effectiveness With Safety Concerns [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Leflunomide in the Treatment of Palmoplantar Pustulosis [The Cutting Edge]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusion Alefacept is ineffective for the treatment of severe AA. (Source: Archives of Dermatology)

Psoriatic arthritis in Asia

Rheumatology — Mon, 16 Nov 2009 16:00:31 +0100

Geographic or ethnic differences in the occurrence of disease often provide insights into causes of disease and possible opportunities for disease prevention. A wide variation on the incidence and prevalence of PsA was reported in different countries. The prevalence in China was similar to the rest of the world, whereas the incidence and prevalence of PsA was much lower in Japan. Among patients with psoriasis, 6–42% of the Caucasians were reported to have PsA, but figures were lower from Asian countries (1–9%). Divergent distribution of HLA in different ethnic groups and other genetic determinants may account for these differences in prevalence. PsA affects men and women almost equally in Chinese, Japanese and Iranians, which is similar to their Caucasian counterparts. Polyarth...

TNF{alpha} shedding and epidermal inflammation are controlled by Jun proteins [Research Papers]

Genes and Development — Mon, 16 Nov 2009 15:02:32 +0100

Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNF play a major role in this phenotype. Here we define the underlying molecular mechanism using genetic mouse models. We show that Jun proteins control TNF shedding in the epidermis by direct transcriptional activation of tissue inhibitor of metalloproteinase-3 (TIMP-3), an inhibitor of the TNF-converting enzyme (TACE). TIMP-3 is down-regulated and TACE activity is specifically increased, leading to massive, cell-autonomous TNF shedding upon loss of both JunB and c-Jun. Consequently, a prominent TNF-dependent cytokine cascade is initiated in the epidermis, inducing severe skin inflammation and perinatal death of newborns from exha...

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Nail Psoriasis: Clinical Presentation and Best Practice Recommendations

Drugs — Mon, 16 Nov 2009 02:06:59 +0100

(Source: Drugs)

Using 'number needed to treat' to express the magnitudes of benefit of ultraviolet B phototherapy and of antitumour necrosis factor-α therapies for psoriasis

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

Using 'number needed to treat' to express the magnitudes of benefit of ultraviolet B phototherapy and of antitumour necrosis factor-alpha therapies for psoriasis.

The British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

Authors: Dawe RS PMID: 19919632 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Dermatology — Sat, 14 Nov 2009 14:03:31 +0100

Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Psoriasis — Sat, 14 Nov 2009 14:03:31 +0100

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Homeopathic and conventional therapies for chronic skin diseases: A prospective study on effectiveness and safety

European Journal of Integrative Medicine — Fri, 13 Nov 2009 13:55:09 +0100

Conclusions: The treatment of chronic skin diseases with homeopathic remedies appears to be more safe and satisfactory to the patient when compared with conventional medication, with improvement in quality of life and general health up to 2 years after start of the treatment. (Source: European Journal of Integrative Medicine)

Evidence based integrative medicine

European Journal of Integrative Medicine — Fri, 13 Nov 2009 13:55:05 +0100

Integrative approaches have played an essential role in the treatment of dermatological diseases since a long time. Many current standard treatments can be considered integrative such as phototherapy, climate therapy (such as staying at high altitude or at the sea), special training on how to handle a disease, special diets and psychological approaches. Furthermore the amount of well-controlled studies on complementary medicine in the treatment of dermatological disorders has increased within the last years. Besides different therapies derive from natural remedies, such as fumaric acid or psoralene (used e.g. in the treatment of psoriasis).An example reflecting the integrative approach in dermatology is the treatment of atopic eczema—an inflammatory, chronically relapsing, non-contagious...

Adalimumab in the management of palmoplantar psoriasis.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

Authors: Ghate JV, Alspaugh CD Palmoplantar pustular psoriasis (PPP) is an uncommon form of chronic psoriasis. Characterized by sterile, intraepidermal pustules located on the palms and soles, it is highly resistant to treatment. Our patient presented with palmar inflammation and throbbing joint pain in his hands, as well as erythematous, pustular, and micaceous scaling skin on his right foot, legs, elbows, and hands. Approximately 4 percent of his body surface area was involved and he was diagnosed with PPP after skin biopsy. After conventional therapy failed, the patient underwent treatment with adalimumab and the majority of his symptoms resolved after 16 weeks of therapy. Adalimumab may be effective for the treatment of PPP. Adalimumab, a fully human immunoglobulin G1 monoclonal an...

Evidence-based (S3) guideline for the treatment of psoriasis vulgaris – Update: "Therapeutic options" and "Efalizumab"

JDDG — Fri, 13 Nov 2009 00:00:00 +0100

In February 2009, the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) had recommended the suspension of efalizumab's (Raptiva®) marketing authorization, because its benefits in the treatment of psoriasis were modest, while there was a risk of serious side effects in patients receiving the medicine, including the occurrence of progressive multifocal leukoencephalopathy (PML). The guideline group has changed the guideline accordingly. (Source: JDDG)

Ustekinumab: new option for moderate-to-severe psoriasis

Prescriber — Fri, 13 Nov 2009 00:00:00 +0100

Ustekinumab (Stelara), a novel biologic for the treatment of moderate-to-severe plaque psoriasis, targets interleukins rather than TNF-alpha. In our New products review, Steve Chaplin presents the clinical data relating to its efficacy and adverse effects and Dr Downs discusses its place in psoriasis treatment. Copyright © 2009 Wiley Interface Ltd (Source: Prescriber)

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Apolipoprotein ε4 allele is associated with psoriasis severity

Archives of Dermatological Research — Thu, 12 Nov 2009 18:38:38 +0100

Abstract Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls. Patients and controls were genotyped for the APOE-ε2/ε3/ε4 polymorphism, and allele and genotype frequencies were statistically compared between the two groups and ...

Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases

Annals of the Rheumatic Diseases — Thu, 12 Nov 2009 18:02:12 +0100

Conclusions: Based on 10 years of clinical trial experience across six diseases, this safety report and the established efficacy of adalimumab in these diseases provide the foundation for a better understanding of its benefit–risk profile. (Source: Annals of the Rheumatic Diseases)

Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control study

Annals of the Rheumatic Diseases — Thu, 12 Nov 2009 18:02:11 +0100

Conclusions: Patients with AS have an increased risk of clinical vertebral fracture but not of non-vertebral fractures, while the risk of any clinical fracture is increased in patients with concomitant inflammatory bowel disease. The mechanism by which non-steroidal anti-inflammatory drugs reduce the risk of any clinical fracture warrants further research. (Source: Annals of the Rheumatic Diseases)

Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine

Indian Journal of Dermatology, Venereology and Leprology — Thu, 12 Nov 2009 14:01:24 +0100

Hazarika DebeekaIndian Journal of Dermatology, Venereology, and Leprology 2009 75(6):638-638Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure of an initial systemic steroid. Blood pressure, pulse, and fetal heart sounds were recorded every 12 hours, and ultrasonography and blood parameters, biweekly. Cyclosporine was tapered and stopped after delivery of two healthy babies at 38 weeks. We conclude that cyclosporine can be an option in the management...

Increased Serum Levels of Growth-Related Oncogene-a in Patients with Generalized Pustular Psoriasis

Karger Publishers — Wed, 11 Nov 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000258674) (Source: Karger Publishers)

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Reliability, Validity, and Responsiveness to Change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for Measuring Body Surface Area Affected by Psoriasis.

The British Journal of Dermatology — Wed, 11 Nov 2009 00:00:00 +0100

Conclusion: Our study suggests that the PREPI is a reliable, valid, and responsive measure of body surface area affected by psoriasis that may be useful for future epidemiologic research. PMID: 19906216 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Basement membrane antibodies in sera of haematopoietic cell recipients are associated with graft-versus-host disease

Journal of the European Academy of Dermatology and Venereology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusions Circulating BMZ antibodies are significantly associated with chronic GvHD in contrast to uncomplicated HCT. Recurrent mucocutaneous lesions in chronic inflammatory skin disorders may liberate antigens, which may lead to production of BMZ antibodies, particularly in the context of GvHD-mediated reduced self-tolerance. (Source: Journal of the European Academy of Dermatology and Venereology)

TCRgamma gene rearrangement in cutaneous T-cell lymphoma: comparative study of PCR with denaturing gradient gel electrophoresis and GeneScan analysis.

The British Journal of Dermatology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusions BIOMED-2-GS analysis of the TCRgamma gene is as sensitive and specific as DGGE for CTCL diagnosis. In addition, BIOMED-2-GS is less time-consuming and gives more information concerning the size and nature of TCR-GR. PMID: 19906072 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Infliximab for the treatment of psoriasis in Greece. Four years of clinical experience at a single center.

The British Journal of Dermatology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusions. The above data confirm previous reports that treatment with infliximab is an efficacious and safe option for patients with moderate to severe plaque psoriasis (and/or arthritis). Long-term follow-up, continued pharmacovigilance, and controlled comparative studies will be required to fully evaluate its use in psoriasis. PMID: 19906069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Daily practice assessment of liver injury in patients with psoriasis on methotrexate

British Journal of Dermatology — Mon, 09 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

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Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial

British Journal of Dermatology — Mon, 09 Nov 2009 00:00:00 +0100

Conclusions Ustekinumab improves HRQoL in patients with moderate-to-severe psoriasis. Patient-reported outcomes measured a treatment effect beyond that indicated by clinical measures. (Source: British Journal of Dermatology)

Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial.

The British Journal of Dermatology — Mon, 09 Nov 2009 00:00:00 +0100

Daily practice assessment of liver injury in patients with psoriasis on methotrexate.

The British Journal of Dermatology — Mon, 09 Nov 2009 00:00:00 +0100

Authors: Driessen RJ, van de Kerkhof PC, de Jong EM PMID: 19903179 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Linear psoriasis.

Dermatol Online J — Sat, 07 Nov 2009 22:36:03 +0100

Authors: Chien P, Rosenman K, Cheung W, Wang N, Sanchez M A 33-year-old man presented with verrucous, red-brown papules, which coalesced into linear plaques on the right buttock, waist, thigh, and genitals. A skin biopsy was consistent with psoriasis, and the unilateral distribution in a linear pattern led to a diagnosis of linear psoriasis, which is a rare variant of psoriasis. Although histopathologically it can be difficult to distinguish from inflammatory linear verrucous epidermal nevus (ILVEN), linear psoriasis presents in adulthood and responds to conventional topical antipsoriatic therapies. PMID: 19891912 [PubMed - in process] (Source: Dermatol Online J)

Psoriasis not independently linked to ischemic heart disease

MedWire News - Dermatology — Sat, 07 Nov 2009 13:59:13 +0100

Psoriasis may not be a clinical risk factor for ischemic heart disease hospitalization, Dutch study findings suggest. (Source: MedWire News - Dermatology)

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Psoriasis not independently linked to ischemic heart disease

MedWire News - Psoriasis — Sat, 07 Nov 2009 13:59:13 +0100

Psoriasis may not be a clinical risk factor for ischemic heart disease hospitalization, Dutch study findings suggest. (Source: MedWire News - Psoriasis)

Optical coherence tomography imaging of psoriasis vulgaris: correlation with histology and disease severity

Archives of Dermatological Research — Fri, 06 Nov 2009 08:49:01 +0100

Abstract Epidermal thickness (ET) has been suggested as a surrogate measure of psoriasis severity. Optical coherence tomography (OCT) is a recent imaging technology that provides real-time skin images to a depth of 1.8 mm with a micrometre resolution. OCT may provide an accurate in vivo measure of ET. It is, therefore, speculated that OCT may be used in the assessment of psoriasis vulgaris. A total of 23 patients with psoriasis vulgaris were systematically evaluated by OCT imaging and skin biopsy during treatment. Biopsies were graded for disease severity, and additional evaluation was done by the physician via psoriasis area and severity index (PASI) score, and by the patient through measures such as self-administered PASI, psoriasis life stress inventory index and d...

Psoriatic arthritis 'common' among people with skin condition

Arthritis Research Campaign — Fri, 06 Nov 2009 00:00:00 +0100

A new study suggests that as many as 14 per cent of people with the skin disorder psoriasis may also have a related form of arthritis. (Source: Arthritis Research Campaign)

Psoriasis - A Disability with Emotional and Physical Toll

Disabled World — Thu, 05 Nov 2009 22:02:26 +0100

Psoriasis is a real disability that affects approximately one million Canadians. A recent Canadian survey found that the causes and effects of this chronic, recurrent skin disorder are often misunderstood - and the result of these misperceptions can leave a lasting negative impact on those who suffer from this debilitating immune system disease. (Source: Disabled World)

Psoriatic arthritis common in people with psoriasis

Reuters: Health — Thu, 05 Nov 2009 21:58:32 +0100

NEW YORK (Reuters Health) - As many as 14 percent of people with psoriasis may also have psoriatic arthritis, research shows. (Source: Reuters: Health)

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[A man with erythodermia, muscle weakness and weight loss.]

Tidsskrift for den Norske Laegeforening — Thu, 05 Nov 2009 00:00:00 +0100

Authors: Gran JT, Gunnarsson R, Mørk NJ A man in his late fifties was treated with acitretin for psoriasis. The treatment was discontined when liver enzymes started to increase. He subsequently developed erythrodermia, weakness of proximal muscle groups, heliotrope rash, Gottron's papules and elevation of creatine kinase to more than 9000 U/L. However, histological examination of a muscle biopsy displayed neuropathic atrophy and only a few scattered necrotic fibers. Alpha 1 foetoprotein was substantially elevated (1600 kU/L) and computed tomography showed two hepatic tumors, lytic lesions in the spine and in the ninth rib. Although no chronic liver disease could be documented, the patient was found to have a hepatocellular carcinoma which presented as dermatomyositis and erythrode...

Annual Evidence Update on Psoriasis: 2-6 November 2009

NLH — Wed, 04 Nov 2009 13:56:34 +0100

An update of the evidence on this topic from NHS Evidence - skin disorders (Source: NLH)

Psoriasis: Find relief for your symptoms

MayoClinic.com Full Feed — Wed, 04 Nov 2009 06:00:00 +0100

Psoriasis — Comprehensive overview covers causes, symptoms and treatments of this chronic skin disorder. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)

V. Bemerkungen über psoriasiforme Salvarsan -- (Syntharsan) Exantheme und Beeinflussung der morphologischen Gestaltung der Psoriasis bei einem Luetiker durch spezifische Therapie

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:372-383 (DOI:10.1159/000257651) (Source: Dermatology)

Treatment of erythrodermic psoriasis in HCV+ patient with adalimumab

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

Erythrodermic psoriasis is a severe and disabling variant of psoriasis. The authors present the case of a 48-year-old man with psoriasis and hemophilia presented with a history of hepatitis C virus (HCV) infection treated with pegylated interferon alpha-2a and ribavirin therapy. At the end of antiviral therapy, skin manifestation progressively worsened, becoming erythrodermic, with lack of efficacy of steroid therapy. The authors decided to start biological therapy with induction dose of adalimumab (Humira, Abbott Laboratories, Abbott Park, Chicago, IL) 80 mg at Week 0 and 40 mg weekly. In our case, this resulted in a highly effective and safe treatment. (Source: Dermatologic Therapy)

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Ultrasound evaluation of clobetasol propionate 0.05% foam application in psoriatic and healthy skin: a pilot study

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

The aim of the present study was to evaluate through ultrasound imaging the response to treatment of twice and once daily application of clobetasol propionate 0.05% foam on psoriatic skin as well as the atrophogenic potential of once daily application of the foam on healthy skin. The study included a total of 40 participants, 30 affected by Psoriasis vulgaris and 10 healthy volunteers. Patients with psoriasis were branched in two groups of 15 subjects: in the first group, clobetasol propionate 0.05% foam was applied twice daily for up to 2 weeks on targeted plaques, in the second group, it was applied once daily for up to 4 weeks. Ten healthy adult volunteers were instructed to apply the foam to a 4 × 4 cm area on the volar aspect of the forearm once daily for 4 weeks. Ultrasound evaluati...

On World Psoriasis Day The IPC Hosts Latin American Dermatologists For Educational Symposium To Elevate Global Knowledge Of Psoriasis

Health News from Medical News Today — Mon, 02 Nov 2009 11:00:00 +0100

A first-of-its-kind symposium has convened today that brings together U.S. and Latin American dermatologists in an effort to elevate the global understanding of psoriasis and its treatment. (Source: Health News from Medical News Today)

Subclinical atherosclerosis in patients with chronic psoriasis: a potential association

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Conclusion The increased carotid artery IMT in patients with chronic psoriasis suggesting that chronic psoriasis is associated with subclinical atherosclerosis with increased risk of cardiovascular disease. So, dermatologists should advice their patients to avoid traditional cardiovascular risk factors and to routinely checkup to reduce cardiovascular morbidity and mortality. (Source: Journal of the European Academy of Dermatology and Venereology)

Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation

Experimental Dermatology — Mon, 02 Nov 2009 00:00:00 +0100

In this study, skin biopsies from both healthy-looking and lesional skin of patients with psoriasis and superficial spreading BCC were collected and the expression of PAR-2 immunoreactivity in tryptase-positive mast cells was analysed. PAR-2 expression was confirmed in vitro in different mast cell populations. Cord-blood derived mast cells (CBMC) were stimulated with a PAR-2 activating peptide, 2-furoyl-LIGRLO-NH2. Consequently, IL-8 and histamine production was analysed in the supernatants. We observed a significant increase in the percentage of mast cells expressing PAR-2 in the lesional skin of psoriasis and BCC patients compared with the healthy-looking skin. HMC-1.2, LAD-2 and CBMC mast cells all expressed PAR-2 both intracellularly and on the cell surface. CBMC activation with the PA...

Annual evidence update on psoriasis

NeLM - Dermatology — Mon, 02 Nov 2009 00:00:00 +0100

Source: NHS Evidence Area: News NHS Evidence - skin disorders has produced its third annual evidence update on psoriasis, timed to correspond with Psoriasis Awareness Week. The Update includes links to new systematic reviews and guidelines published over the previous year, and a "what's new" analysis discusses the new evidence and its implications for clinical practice. Please see the link below for details. (Source: NeLM - Dermatology)

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Association between Plaque-Type Psoriasis and Perianal Streptococcal Cellulitis and Review of the Literature.

Archives of Iranian Medicine — Sun, 01 Nov 2009 00:00:00 +0100

We describe a four-year-old boy with perianal streptococcal dermatitis who was brought to our clinic with plaque type psoriasis. PMID: 19877754 [PubMed - in process] (Source: Archives of Iranian Medicine)

Lichen Planus Link to Dyslipidemia Found

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

BERLIN — Lichen planus, like psoriasis, appears to be intrinsically associated with an increased prevalence of dyslipidemia, according to a large Israeli case-control study. “Of course, this is a pioneering study and I'd like to see it repeated in other databases. Nevertheless, we suggest that patients with lichen planus might be candidates for dyslipidemia screening,” Dr. Arnon D. Cohen said at the annual congress of the European Academy of Dermatology and Venereology. (Source: Skin and Allergy News)

IL-17A Blocker Shows Early Promise for Psoriasis

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

BERLIN — Selective inhibition of the proinflammatory cytokine interleukin-17A using a novel fully human monoclonal antibody showed considerable early promise for treatment of psoriasis in a phase II double-blind randomized trial. (Source: Skin and Allergy News)

TNF Blocker Risk-Benefit Analysis Proves Favorable

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

BUDAPEST, HUNGARY — More than 100 psoriasis patients treated with adalimumab, etanercept, or infliximab experienced marked clinical improvement for every patient who developed a serious adverse event, according to a risk-benefit analysis of the major randomized trials of the tumor necrosis factor antagonists. (Source: Skin and Allergy News)

Antiangiogenesis Offers New Tactic for Inflammatory Disease

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

BUDAPEST, HUNGARY — Topical or oral antiangiogenic therapy may offer a novel avenue of treatment in inflammatory skin diseases such as psoriasis and rosacea. In what he described as the first proof-of-concept study to show that blocking the vascular endothelial growth factor (VEGF) receptor may provide an entirely new approach to treating chronic inflammatory skin conditions, Dr. Michael Detmar presented highlights of his research during a satellite symposium held in conjunction with the annual meeting of the European Society for Dermatological Research. (Source: Skin and Allergy News)

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Ustekinumab Found to Help Improve Sexual Function in Psoriasis Patients

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

BERLIN — Impaired sexual function is extremely common in the setting of moderate to severe psoriasis, and ustekinumab therapy reduces these problems by 10-fold. That's a key quality of life finding from the ongoing randomized double-blind phase III PHOENIX-1 and −2 clinical trials of this human monoclonal antibody directed against the proinflammatory cytokines interkeukin-12 and −23, Dr. Lyn Guenther reported at the annual congress of the European Academy of Dermatology and Venereology. (Source: Skin and Allergy News)

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

Journal of Allergy and Clinical Immunology — Sun, 01 Nov 2009 00:00:00 +0100

Conclusion: Although both responders and nonresponders to etanercept inactivated sepsis cascade cytokines, response to etanercept is dependent on inactivation of myeloid dendritic cell genes and inactivation of the TH17 immune response. (Source: Journal of Allergy and Clinical Immunology)

Psoriasis Linked With a Host of Comorbidities

Internal Medicine News — Sun, 01 Nov 2009 00:00:00 +0100

PORTLAND, ORE. — Psoriasis patients face an increased risk of comorbidities ranging from depression to MI, but most don't know that. “People don't know what you don't tell them, so please educate your patients about these risk factors,” Dr. Theresa Devere said at the annual meeting of the Pacific Dermatologic Association. “We should all be educating and screening people for comorbidities of psoriasis. At the least, perhaps make a handout that lists what they may be at risk for.” (Source: Internal Medicine News)

Efficiency of Biologic Agents in the Treatment of Moderate to Severe Psoriasis.

Actas Dermo-Sifiliograficas — Sun, 01 Nov 2009 00:00:00 +0100

CONCLUSIONS: Assigning the efficacy reported in the 15 published clinical trials, the most efficientbiologic agent in terms of the cost/efficacy ratio was adalimumab, with one PASI 75 response at a cost of euro8,013. For the remaining biologic agents and with different regimens,the cost per responder ranged from euro9,370 to euro17,112. The sensitivity analysis confirmed the robustness of these figures. PMID: 19889301 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Lichen Planus Linked to Dyslipidemia

Family Practice News — Sun, 01 Nov 2009 00:00:00 +0100

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Psoriasis Tx Deemed ‘Challenging’ in Pregnancy

Ob.Gyn. News — Sun, 01 Nov 2009 00:00:00 +0100

BOSTON — Data suggesting that pregnant women with psoriasis have poorer outcomes than those without it highlight the need for more research to determine whether the outcome discrepancies are a function of the disease itself, comorbidities, or treatment side effects, according to Dr. Alexa Boer Kimball. (Source: Ob.Gyn. News)

First IL-12 and −23 Blocker Approved for Psoriasis, With Safety Requirements

Rheumatology News — Sun, 01 Nov 2009 00:00:00 +0100

The Food and Drug Administration's approval of ustekinumab for moderate to severe plaque psoriasis—the first interleukin-12 and −23 antagonist to be approved in the United States—is accompanied by requirements for a risk management plan and postmarketing studies that address uncertainties about the long-term safety of the biologic. (Source: Rheumatology News)

Benefits of TNF Blockers Outlined

Rheumatology News — Sun, 01 Nov 2009 00:00:00 +0100

Targeting IL-17A Is Promising in Psoriasis Trial

Rheumatology News — Sun, 01 Nov 2009 00:00:00 +0100

BERLIN — Selective inhibition of the proinflammatory cytokine interleukin-17A using a novel fully human monoclonal antibody showed considerable early promise for treatment of psoriasis in a phase II, double-blind, randomized trial. (Source: Rheumatology News)

Mind-Body Connection Has Role in Coping With Psoriasis

Clinical Psychiatry News — Sun, 01 Nov 2009 00:00:00 +0100

PRAGUE — A mind-body connection may play a role in a psoriasis patients' disease adaptation, study data suggest. Lipoprotein levels and the amino-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) correlated with various psychosocial aspects of psoriasis, Dr. Aldona Pietrzak of the Medical University of Lublin, Poland reported at the International Congress of Dermatology. (Source: Clinical Psychiatry News)

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Psoriasis Not Linked to CV Hospitalizations

Cardiology News — Sun, 01 Nov 2009 00:00:00 +0100

BUDAPEST — The last word on the relationship between psoriasis and cardiovascular disease may not be in, according to the results of a new study. Contrary to earlier studies, psoriasis was found to not be an independent risk factor for hospitalization for ischemic heart disease in a large Dutch study, Dr. Marlies Wakkee reported at the annual congress of the European Society for Dermatological Research. (Source: Cardiology News)

Evaluation and Management of Psoriasis: An Internist's Guide

Medical Clinics of North America — Sun, 01 Nov 2009 00:00:00 +0100

This article reviews the epidemiology, clinical features, pathogenesis, comorbidities, and treatment of psoriasis, with special emphasis placed on the new class of medications, biologics, which are revolutionizing the management of the disease. (Source: Medical Clinics of North America)

Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1

Journal of Medical Genetics — Fri, 30 Oct 2009 17:02:04 +0100

Conclusion: The data establish PSORS6 as a confirmed psoriasis susceptibility locus showing interaction with PSORS1. (Source: Journal of Medical Genetics)

CASPAR criteria estimate psoriatic arthritis prevalence in psoriasis patients

MedWire News - Dermatology — Fri, 30 Oct 2009 00:00:00 +0100

UK researchers have reported a 13.8% prevalence of psoriatic arthritis in community-based patients with psoriasis according to the classification criteria for Psoriatic arthritis. (Source: MedWire News - Dermatology)

Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.

Cytokine — Fri, 30 Oct 2009 00:00:00 +0100

Authors: Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S Targeting major proinflammatory cytokines such as IL-1beta and TNFalpha is of great interest in patients with chronic inflammatory diseases, including rheumatoid arthritis, colitis, and psoriasis. The cytokine Interleukin (IL)-32 induces proinflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and chemokines. We previously used an IL-32 ligand-affinity column to purify proteinase 3, which is abundantly expressed in neutrophil and monocytic leukocytes but not in other cell types, and found that IL-32 is mainly produced by monocytic leukocytes. This evidence suggested that silencing endogenous IL-32 by short hairpin RNA (shRNA) in monocytic cells might reveal the precise function o...

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British Association of Dermatologists' guidelines for biologic interventions for psoriasis 2009.

The British Journal of Dermatology — Thu, 29 Oct 2009 15:18:22 +0100

Authors: Smith CH, Anstey AV, Barker JN, Burden AD, Chalmers RJ, Chandler DA, Finlay AY, Griffiths CE, Jackson K, McHugh NJ, McKenna KE, Reynolds NJ, Ormerod AD, PMID: 19857207 [PubMed - in process] (Source: The British Journal of Dermatology)

Efficacy of 308-nm excimer light for Japanese patients with psoriasis

The Journal of Dermatology — Thu, 29 Oct 2009 14:00:46 +0100

Ultraviolet irradiation therapy, including psoralen and ultraviolet A therapy and narrow-band ultraviolet B (310[ndash]312 nm) therapy, is a widely used and highly efficient treatment modality for psoriasis. Therapy with 308-nm excimer light has been reported to be effective for the treatment of psoriasis vulgaris. To evaluate the efficacy of 308-nm excimer light therapy for Japanese psoriasis patients, seven patients (six men and one woman) with plaque-type psoriasis were treated with 308-nm excimer light at 7[ndash]14-day intervals. The Psoriasis Severity Index (PSI) was calculated for individual plaques in order to assess the effectiveness of the therapy. A 74.9% mean improvement in the PSI was observed after 10 treatment sessions. These results suggested that targeted irradiation with ...

Living With Severe Psoriasis Can Affect Every Aspect Of Life

Health News from Medical News Today — Thu, 29 Oct 2009 09:00:00 +0100

Findings from a national survey Psoriasis Uncovered, show that for those with the most severe1 form of the condition, psoriasis has an irreversible effect on one in two patients' lives. (Source: Health News from Medical News Today)

JAX publishes online tool for exploring autoimmune disease gene networks

EurekAlert! - Medicine and Health — Thu, 29 Oct 2009 04:00:00 +0100

(Jackson Laboratory) To help researchers investigate the common pathways in autoimmune diseases, The Jackson Laboratory has published "Pathways to Discovery: Autoimmune Diseases," a unique, interactive, and publicly accessible online resource that illustrates the genetic networks involved in five common autoimmune diseases: inflammatory bowel disease, rheumatoid arthritis, asthma, multiple sclerosis and psoriasis. (Source: EurekAlert! - Medicine and Health)

PhotoMedex Offers Free Seminar For Psoriasis Patients: "A Win For Your Skin In The Daily Fight Against Psoriasis"

Health News from Medical News Today — Thu, 29 Oct 2009 03:00:00 +0100

PhotoMedex, Inc. (Nasdaq: PHMD) a leading provider of advanced dermatology, clinical skincare and medical laser products, is hosting a free seminar in Indianapolis, IN on November 17, 2009. (Source: Health News from Medical News Today)

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Progress in Studies of the Genetics of Ankylosing Spondylitis

Arthritis Research and Therapy — Thu, 29 Oct 2009 00:00:00 +0100

The advent of high throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the MHC genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the immunological pathways involved in AS, and raising novel potential therapies. The IL23R findings and subsequent immunological investigations suggest that targeted intervention in the TH17 system is likely to have major therapeutic benefit, as it does in the genetically related diseases, inflammatory bowel disease and psoriasis. Fur...

Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population

Arthritis and Rheumatism — Thu, 29 Oct 2009 00:00:00 +0100

The results of a recent genome-wide association study have shown that ERAP1 and IL23R are associated with ankylosing spondylitis (AS) in Caucasian populations from North America and the UK. Based on these findings, we undertook the current study to investigate whether single-nucleotide polymorphisms (SNPs) covering the genes ERAP1 and IL23R are associated with AS in a Han Chinese population.A case-control study was performed in Han Chinese patients with AS (n = 527) and controls (n = 945) from Shanghai and Nanjing. All patients met the modified New York criteria for AS. The Sequenom iPlex platform was used to genotype cases and controls for 21 tag SNPs covering IL23R and 38 tag SNPs covering ERAP1. Statistical analysis was performed using the Cochran-Armitage test for trend.Multiple SNPs i...

Increased Amount of Visceral Fat in Patients with Psoriasis Contributes to Metabolic Syndrome

Karger Publishers — Wed, 28 Oct 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000254482) (Source: Karger Publishers)

Acne vulgaris und Seborrhoe, Rosacea, Psoriasis vulgaris, Parapsoriasis, Lupus erythematodes

Dermatology — Wed, 28 Oct 2009 23:00:00 +0100

Dermatologica 1948;95:91-101 (DOI:10.1159/000255936) (Source: Dermatology)

Wide-spectrum profile of inflammatory mediators in the plasma and scales of patients with psoriatic disease.

Cytokine — Wed, 28 Oct 2009 00:00:00 +0100

Authors: Deeva I, Mariani S, De Luca C, Pacifico V, Leoni L, Raskovic D, Kharaeva Z, Korkina L, Pastore S Psoriasis is a chronic recurrent inflammatory disorder of the skin. Clinical subtypes include psoriasis vulgaris (PV), psoriatic arthropathy, and erythrodermic psoriasis. Aim of this study was to analyse relevant inflammatory mediators in the plasma of patients with distinct subtypes of active psoriasis, and in the scales of mild-to-moderate PV patients, and correlation to disease severity. Compared to healthy controls (n=10), patients affected by very severe forms of psoriasis (n=30) were characterized by increased plasma levels of IL-4, IL-6, MCP-1, VEGF and in particular PDGFbb. Each group with severe psoriasis had distinct characteristic features of plasma cytokine profile. Mil...

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AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis

Current Opinion in Investigational Drugs — Tue, 27 Oct 2009 00:00:00 +0100

No description available (Source: Current Opinion in Investigational Drugs)

A Rare Presentation of Mycosis Fungoides Mimicking Psoriasis Vulgaris

Karger Publishers — Mon, 26 Oct 2009 23:00:00 +0100

Case Rep Dermatol 2009;1:60-65 (DOI:10.1159/000249148) (Source: Karger Publishers)

Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity

Mediators of Inflammation — Mon, 26 Oct 2009 16:23:30 +0100

The precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected. Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes. In systemic lupus erythematosus, a so-called interferon...

Intravitreal administration of infliximab in 3 patients with neovascular age-related macular degeneration

Optometry - Journal of the American Optometric Association — Mon, 26 Oct 2009 15:19:22 +0100

The intravitreal delivery of antivascular endothelial growth factor (anti-VEGF) agents has revolutionized the treatment of neovascular age-related macular degeneration (AMD). Recent histopathologic findings have suggested an immune-mediated response in AMD lesions consisting of macrophages, lymphocytes, and mast cells. Macrophage infiltration initiates angiogenesis by releasing cytokines such as vascular endothelial growth factor and tumor necrosis factor (TNF). Along with anti-VEGF agents, those that inhibit the action of TNF may have a therapeutic benefit in neovascular AMD. Infliximab (Remicade; Schering-Plough, Athens, Greece), is an anti-TNF monoclonal antibody used in the treatment of rheumatoid arthritis, psoriasis, inflammatory bowel disease, and spondyloartopathies. The authors of...

Metabolic syndrome risk high in psoriasis patients

MedWire News - Psoriasis — Sat, 24 Oct 2009 12:59:38 +0100

The metabolic syndrome affects more than half of patients with psoriasis, with the likelihood of the syndrome increasing with the severity of the skin condition, delegates were told at the 18th Congress of the European Academy of Dermatology and Venereology in Berlin, Germany. (Source: MedWire News - Psoriasis)

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Wavelet analysis of Laser Doppler Flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior.

Clinical Hemorheology and Microcirculation — Sat, 24 Oct 2009 06:28:03 +0100

Authors: Häfner HM, Bräuer K, Radke C, Eichner M, Strölin A We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis.A total of 68 patients with primary BCCs and 40 patients with PP were included in the study. LDF time series were separated in four scaling levels corresponding to the influences of sympathetic activity (SL1), myogenic activity in the vessel wall (SL2), respiration (SL3) and heart beat (SL4).In BCC, SL1 decreased compared to healthy skin. In all other scaling levels, we found a statistically significant increase of the SLs compared to healthy skin. These in...

Splenic tuberculosis during psoriasis treatment with infliximab

Anais Brasileiros de Dermatologia — Fri, 23 Oct 2009 12:59:34 +0100

A psoríase é doença crônica que afeta a pele e, eventualmente, as articulações. A terapia biológica age bloqueando citocinas inflamatórias implicadas na patogênese da doença, dentre elas o fator de necrose tumoral alfa. Este também tem papel na defesa do hospedeiro contra o Mycobacterium tuberculosis. Relata-se um caso de psoríase com boa resposta ao infliximabe, porém com desenvolvimento de tuberculose esplênica durante o tratamento.Psoriasis is a chronic inflammatory disease affecting the skin and occasionally the joints. The biological agents have been engineered to target a specific step in the inflammatory cascade that leads to psoriasis, including tumor necrosis factor, which has a central role in the host defense against Mycobacterium tuberculosis. This is a case repor...

New Guidelines For The Management Of Psoriasis With Ultraviolet Light Therapy

Health News from Medical News Today — Fri, 23 Oct 2009 08:00:00 +0100

Based on an extensive review of the highest quality scientific literature on psoriasis and the opinion of recognized psoriasis experts, the American Academy of Dermatology (Academy) has released new guidelines of care for the management and treatment of psoriasis with ultraviolet (UV) light therapy also known as phototherapy. (Source: Health News from Medical News Today)

New Guidelines for the Management of Psoriasis with Ultraviolet Light Therapy

MedlinePlus Health News — Fri, 23 Oct 2009 04:35:55 +0100

Source: American Academy of Dermatology Related MedlinePlus Topic: Psoriasis (Source: MedlinePlus Health News)

Metabolic syndrome risk high in psoriasis patients

MedWire News - Dermatology — Fri, 23 Oct 2009 00:00:00 +0100

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Fumaderm®: what is the evidence for its efficacy and safety in psoriasis?

NeLM - Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Source: North West Medicines Information Centre Area: Evidence > Medicines Q & A Fumaderm® (fumaric acid esters) tablets are licensed in Germany for the treatment of adults with moderate to severe plaque psoriasis for whom topical therapy is ineffective. Although unlicensed in the UK and available only through drug import agencies, Fumaderm® is used by specialist dermatology centres. Limited evidence, including only two randomised controlled trials, indicates that Fumaderm® is beneficial in patients with moderate to severe psoriasis, particularly chronic plaque, guttate or pustular disease; at least 50% of patients treated with Fumaderm® will have a reduction of about 70% or more in Psoriasis Area and Severity Index (PASI) score after 16 weeks of treatment. Patients with recalcitr...

Simple and rapid screening for HLA-Cw*06 in Polish patients with psoriasis

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions. The low cost, high-throughput capacity and requirement for small sample amounts make this procedure a useful one for HLA-Cw*06 typing in clinical practice and large population studies. We recommend that patients with psoriasis diagnosed before 45 years of age should be considered for diagnostic HLA-Cw*06 typing. (Source: Clinical And Experimental Dermatology)

Topical tazarotene vs. coal tar in stable plaque psoriasis

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions. Tazarotene 0.1% gel has comparable clinical efficacy to CCT 5% ointment. CCT ointment remains a cost-effective therapy for plaque psoriasis. (Source: Clinical And Experimental Dermatology)

Therapeutic options for palmoplantar pustulosis

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

Palmoplantar pustulosis (PPP) is a common chronic and recurrent pustular dermatosis characterized by multiple sterile pustules and erythematous plaques on the palms and soles. The exact cause and pathogenesis of the disease remain unknown, and there is still debate about whether PPP is a variant of psoriasis or a distinct condition. A review of the medical literature revealed that a wide range of treatments have been used in the treatment of PPP over the years. The literature in PPP is restricted to case reports or small case series, and there is a lack of well-documented clinical studies, which makes it difficult to select an ideal therapy for the condition. The purpose of this review is to discuss the current therapy options for PPP, based on results of randomized controlled trials. (Sou...

Retrospective analysis of systemic treatments for psoriasis patients attending a Psocare center in Florence. Relevance of biological drugs use and comorbidities

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions Current treatments have to consider general health conditions and patients habits. In this picture, biological drugs are emerging as the therapy of choice for their good efficacy in the long term management of psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)

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An Italian shared dermatological and rheumatological proposal for the use of biological agents in psoriatic disease

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusion We provide a shared dermatological and rheumatological proposal for the use of biological agents in PD. (Source: Journal of the European Academy of Dermatology and Venereology)

The risk of psoriatic arthritis remains constant following initial diagnosis of psoriasis among patients seen in European dermatology clinics

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions The incidence of PsA was constant after initial diagnosis of psoriasis, leading to a higher prevalence of concomitant PsA over time. PsA is associated with decreased QoL and increased work-related problems, HCRU and comorbidities. Dermatologists should screen for PsA in their patients, especially long-standing patients who did not initially present with PsA. (Source: Journal of the European Academy of Dermatology and Venereology)

Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production

Blood — Thu, 22 Oct 2009 16:02:37 +0100

T helper 17 (Th17) cells produce IL-17 but can also make tumor necrosis factor, interleukin (IL)–6, IL-10, IL-21, and IL-22. These cytokines collectively contribute to the functional outcome of the Th response. IL-22 plays a critical role in some Th17-associated diseases, such as psoriasis, but its relationship to IL-17 remains controversial. Here, we used a systematic multiparametric analysis of Th-17-associated cytokines, which revealed the unexpected finding that the regulation pattern of IL-22 was most closely related to interferon-, the prototypical Th1 cytokine, and not to IL-17. To explain this observation, we systematically tested the role of Th1- and Th17-inducing cytokines. We could show that IL-12 and IL-23 induced high levels of IL-22 but no IL-17. Conversely, transformin...

Nail Psoriasis

eMedicineHealth.com — Thu, 22 Oct 2009 07:00:00 +0100

(Source: eMedicineHealth.com)

Upregulation of cathepsin S in psoriatic keratinocytes

Experimental Dermatology — Wed, 21 Oct 2009 23:00:00 +0100

Please cite this paper as: Upregulation of cathepsin S in psoriatic keratinocytes. Experimental Dermatology 2009.Abstract: Cathepsin S (CATS) is a cysteine protease, well known for its role in MHC class II-mediated antigen presentation and extracellular matrix degradation. Disturbance of the expression or metabolism of this protease is a concomitant feature of several diseases. Given this importance we studied the localization and regulation of CATS expression in normal and pathological human/mouse skin. In normal human skin CATS-immunostaining is mainly present in the dermis and is localized in macrophages, Langerhans, T- and endothelial cells, but absent in keratinocytes. In all analyzed pathological skin biopsies, i.e. atopic dermatitis, actinic keratosis and psoriasis, CATS staining is...

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Influence of narrowband UVB phototherapy on vitamin D and folate status

Experimental Dermatology — Wed, 21 Oct 2009 23:00:00 +0100

Conclusion: Low-dose nUVB treatment gives a significant increase (P < 0.001) of the vitamin D status in persons with low initial levels of 25(OH)D, but no effect on the folate level. (Source: Experimental Dermatology)

Internet-supported gathering of treatment data and patient benefits in psoriasis

Journal of the European Academy of Dermatology and Venereology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusion The findings suggest that patients in the online sample are less satisfied with their health care, which also could have been their motive for participating online. It is important to gather data online because it increases the data pool and permits inclusion of people who are not incorporated in clinical settings. However, online data cannot directly replace data collected in clinics because they are also subject to selections. (Source: Journal of the European Academy of Dermatology and Venereology)

Treatment of scalp psoriasis with clobetasol-17 propionate 0.05% shampoo: a study on daily clinical practice

Journal of the European Academy of Dermatology and Venereology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusions Short-contact treatment with clobetasol-17 propionate 0.05% shampoo has high user convenience and patient satisfaction rates. Moreover, the treatment is well-tolerated and efficacious from patients' perspective. Subgroup analyses did not reveal factors predicting treatment outcome, although treatment success tended to be more evident in patients who had received fewer treatments previously. (Source: Journal of the European Academy of Dermatology and Venereology)

Psoriasis

New England Journal of Medicine — Tue, 20 Oct 2009 23:00:00 +0100

To the Editor: In their review of psoriasis, Nestle et al. (July 30 issue)1 focus only on the genetic aspect ... (Source: New England Journal of Medicine)

Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.

Regulatory Peptides — Tue, 20 Oct 2009 00:00:00 +0100

CONCLUSIONS: CRH might downregulate the expression of VEGF through the CRH-R1 and MAPK (p38 MAPK and JNK1/2) signaling pathways in human HaCaT cells. PMID: 19852986 [PubMed - as supplied by publisher] (Source: Regulatory Peptides)

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Extramammary Paget's Disease of the Penis and Scrotum

The Journal of Urology — Tue, 20 Oct 2009 00:00:00 +0100

Extramammary Paget's disease (EMPD) of the penis and scrotum is a rare genitourinary malignancy primarily affecting patients 60 to 70 years old. Patients present with pruritus and pain associated with an erythematous, eczematous or ulcerated plaque-like lesion with well-defined borders. The most frequent location of EMPD in males is the penoscrotal junction, followed by lesions of the scrotum and inguinal area (). There is often a delay in diagnosis of EMPD until therapies for more common diseases including psoriasis, eczematous dermatitis and fungal infections fail. (Source: The Journal of Urology)

Now I can't wait to get dressed up

Daily Express - Health — Mon, 19 Oct 2009 23:00:00 +0100

FOR the best part of half a century Wendy Garnett shopped for clothes designed to hide her body. Plagued by the chronic skin condition psoriasis, the 58-year-old from Thorverton, near Exeter, has gone to extreme lengths to avoid the embarrassment of strangers staring at her red, dry and scaly appearance. Yet thanks to a breakthrough in treatment she is free at last to wear what she wants. (Source: Daily Express - Health)

Serum cytokines and growth factor levels in Japanese patients with psoriasis

Clinical And Experimental Dermatology — Sun, 18 Oct 2009 23:00:00 +0100

Discussion. Serum levels of TNF-[alpha], IFN-[gamma], IL2, IL-6, IL-7, IL-8, IL-12, IL-17, IL-18 and VEGF were positively correlated and that of IL-10 was negatively correlated with PASI in Japanese patients with psoriasis. These parameters might be useful for determining the disease activity of psoriasis. (Source: Clinical And Experimental Dermatology)

Flaccid pustular eruption

Journal of the American Academy of Dermatology — Sat, 17 Oct 2009 12:58:01 +0100

A healthy 51-year-old white male was referred to our department for a 3-year history of a mildly pruritic eruption on his trunk, axillae, upper extremities, and proximal lower extremities. He described the lesions as papules and plaques that develop into flaccid “pus-filled” vesicles and bullae that very quickly denuded, leaving pink hyperpigmented macules with peripheral scale (). The eruption was most severe in the summer and was exacerbated with moderate exercise. Natural ultraviolet light had no effect on the patients' skin lesions. No other exacerbating or inciting factors could be identified. His current medications were hydrochlorothiazide and aspirin, neither of which had been initiated or changed around the time of disease onset. The patient had been previously diagnosed with ...

Placebo-controlled trial supports PUVA’s efficacy in plaque-type psoriasis

MedWire News - Psoriasis — Sat, 17 Oct 2009 12:57:52 +0100

Psoralen plus ultraviolet A is a highly efficacious treatment for patients with chronic plaque psoriasis, say researchers. (Source: MedWire News - Psoriasis)

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Biomedical Research Centre Searches For Immunological Biomarkers

Health News from Medical News Today — Sat, 17 Oct 2009 08:00:00 +0100

Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection. (Source: Health News from Medical News Today)

Efficacy of a Single Educative Intervention in Patients with Chronic Plaque Psoriasis

Karger Publishers — Fri, 16 Oct 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000250826) (Source: Karger Publishers)

Topical Clobetasol Propionate in the Treatment of Psoriasis: A Review of Newer Formulations

American Journal of Clinical Dermatology — Fri, 16 Oct 2009 13:00:23 +0100

(Source: American Journal of Clinical Dermatology)

Impact of Psoriasis on Patients Work and Productivity: A Retrospective, Matched Case-Control Analysis

American Journal of Clinical Dermatology — Fri, 16 Oct 2009 13:00:23 +0100

(Source: American Journal of Clinical Dermatology)

Comment on: Liver fibrosis in patients with psoriasis and psoriatic arthritis on long-term, high cumulative dose methotrexate therapy

Rheumatology — Fri, 16 Oct 2009 06:06:48 +0100

(Source: Rheumatology)

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Comment on: Liver fibrosis in patients with psoriasis and psoriatic arthritis on long term, high cumulative dose methotrexate therapy: reply

Rheumatology — Fri, 16 Oct 2009 06:06:48 +0100

(Source: Rheumatology)

Placebo-controlled trial supports PUVA’s efficacy in plaque-type psoriasis

MedWire News - Dermatology — Fri, 16 Oct 2009 00:00:00 +0100

Psoralen plus ultraviolet A is a highly efficacious treatment for patients with chronic plaque psoriasis, say researchers. (Source: MedWire News - Dermatology)

IV. Psoriasis und endokrines System

Dermatology — Thu, 15 Oct 2009 23:00:00 +0100

Dermatologische Zeitschrift 1930;57:362-365 (DOI:10.1159/000252740) (Source: Dermatology)

Induced keratinocyte hyper-proliferation in alpha2beta1 integrin transgenic mice results in systemic immune cell activation.

International Immunopharmacology — Thu, 15 Oct 2009 23:00:00 +0100

In this study, we have followed the integrin transgenic mice for five weeks, where substantial keratinocyte hyper-proliferation, inflammatory infiltration and high cytokine levels within the skin can still be observed. In addition, draining lymph nodes were dramatically increased in size and contained highly activated T cells, as well as APCs secreting large amounts of pro-inflammatory cytokines. Furthermore, the systemic immune response was affected with increased spleen size, elevated cytokine levels in the serum and altered lymphocyte trafficking patterns, very much resembling what is seen in psoriasis patients. Finally, CD4(+) T cell depletion was not able to affect the onset or progression of skin inflammation. This suggests that altered keratinocyte differentiation and proliferation ...

Provectus Reaches Milestone With Completion Of Patient Accrual In Phase 2 Trial Of PH-10 For Psoriasis

Health News from Medical News Today — Thu, 15 Oct 2009 08:00:00 +0100

Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development stage oncology and dermatology biopharmaceutical company, has completed patient accrual and initial treatment in its Phase 2 trial of PH-10 for the treatment of plaque psoriasis. This milestone marks the third Phase 2 clinical trial for which Provectus has completed patient accrual since May 2009. (Source: Health News from Medical News Today)

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Biomedical Research Centre searches for immunological biomarkers

EurekAlert! - Medicine and Health — Thu, 15 Oct 2009 04:00:00 +0100

(King's College London) Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and others. A group of London-based researchers hope that they will be able to identify biomarkers in the tissue and blood, which in future could be used to diagnose these conditions, to predict how they will develop and how an individual will respond to treatment. (Source: EurekAlert! - Medicine and Health)

Ten years of infliximab: Its role in dermatology.

European Journal of Pharmacology — Wed, 14 Oct 2009 23:00:00 +0100

Authors: Mrowietz U, Reich K Psoriasis is a common chronic inflammatory disease of the skin. Psoriatic arthritis may develop in about 20% of psoriasis patients while metabolic syndrome is a frequent comorbidity, and risk of cardiovascular disease is increased in psoriasis patients. Classical systemic treatments have not evolved much during the last decades; biological therapies on the contrary have added most significant progress in systemic treatment during the last 10years. In particular tumor necrosis factor (TNF) blockade has changed the treatment outcomes in moderate to severe psoriasis patients. With drugs such as infliximab treatment goals of 75% improvement of psoriasis lesions together with significant improvement of quality of life can be achieved. Furthermore, skin clearance...

The TNF Superfamily in 2009: New pathways, new indications, and new drugs.

Drug Discovery Today — Wed, 14 Oct 2009 23:00:00 +0100

This report summarizes recent developments in this highly druggable superfamily, including highlights of the latest international TNF conference. Teaser sentence: TNF has become the most successful target of protein drugs, and numerous new biologics in development modulate other TNF superfamily targets, promising to expand on this clinical and commercial success. PMID: 19837186 [PubMed - as supplied by publisher] (Source: Drug Discovery Today)

EADV: Psoriasis Comorbidities May Cut Longevity (CME/CE)

MedPage Today Dermatology — Wed, 14 Oct 2009 17:20:27 +0100

BERLIN (MedPage Today) -- Psoriasis patients have a substantial comorbidity burden that can reduce life expectancy by 10 years or more, according to data presented here. (Source: MedPage Today Dermatology)

EADV: Benefit of Methrotrexate in Psoriasis Will Show Up Early (CME/CE)

MedPage Today Dermatology — Wed, 14 Oct 2009 15:28:29 +0100

BERLIN (MedPage Today) -- A suboptimal response to methotrexate at 12 weeks identified psoriasis patients who were unlikely to benefit from continued therapy at higher doses, a retrospective analysis of clinical-trial data showed. (Source: MedPage Today Dermatology)

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EADV: Agent Clears Lesions, Lessens Psoriatic Arthritis (CME/CE)

MedPage Today Dermatology — Wed, 14 Oct 2009 15:01:41 +0100

BERLIN (MedPage Today) -- In patients with psoriasis and concomitant psoriatic arthritis, treatment with etanercept (Enbrel) improved skin lesions, enthesitis, and dactylitis in a majority of patients, data from a randomized clinical trial showed. (Source: MedPage Today Dermatology)

Natural remedies for acne

NaturalNews.com — Wed, 14 Oct 2009 07:00:00 +0100

(NaturalNews) Acne sucks. But you don't need antibiotics or harsh chemicals to treat it. In addition to altering your diet so that you consume fewer acne-producing foods (dairy products and fried foods, mostly), there are some effective natural remedies that are also useful for clearing up your skin.Below, we've compiled a few of these recommendations from some of the top authors in natural health. Enjoy this short collection, and feel free to share it with others (please give appropriate credit to the original author as well as this NaturalNews page, thank you).Natural remedies for acneBrazilian school kids have acne. There's far less acne in Kenya, Zambia, Malaysia, and rural Japan than is common in Western societies. But if there was any doubt left about the diet-acne connection it shou...

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis.

European Journal of Immunology — Tue, 13 Oct 2009 23:00:00 +0100

This study demonstrates that a T-cell mediator induces a tissue cell mediator with similar effects to its own and therefore suggests the existence of a novel type of pathogenetic cascade. PMID: 19830738 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)

[TNF-alpha inhibitor etanercept and oral cavity carcinoma.]

Revue de Stomatologie et de Chirurgie Maxillo-Faciale — Tue, 13 Oct 2009 23:00:00 +0100

DISCUSSION: The possible development of an oral cavity carcinoma should be taken into account when following a patient under TNF-alpha inhibitor treatment. Anti-TNF treatment has improved the management of patients with severe chronic inflammatory diseases. They allow for a better quality of life. Nevertheless, their immunosuppressive effect should be taken into account when prescribed and during follow-up. PMID: 19836037 [PubMed - as supplied by publisher] (Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale)

EADV: Anti-TNF Exposure Does Not Rule out TNF Inhibitor for Psoriasis (CME/CE)

MedPage Today Dermatology — Tue, 13 Oct 2009 22:32:19 +0100

BERLIN (MedPage Today) -- Prior exposure to anti-tumor necrosis factor (TNF) therapy does not rule out potential benefits from additional anti-TNF therapy for patients with psoriasis, according to data presented here. (Source: MedPage Today Dermatology)

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Vitamin D is nutritional key for prevention of breast cancer

NaturalNews.com — Tue, 13 Oct 2009 07:00:00 +0100

This study suggests women sunbathe with breast tissue exposed to the sun to enhance local vitamin D production. The provision of 400 IU of vitamin D per day has been found to reduce the risk of pancreatic cancer by 43%. - You Don't Have to be Afraid of Cancer Anymore by Bill SardiTaken together, these facts suggest that vitamin D and its derivatives may play a role in regulating the expression of genes and protein products that prevent and inhibit breast cancer. The cancer-stopping power of vitamin D has been documented in osteosarcoma (bone cancer), melanoma, colon cancer, and breast cancer. These cancer cells contain vitamin-D receptors that make them susceptible to the anticancer effects of this vitamin-hormone made by the skin when it is exposed to sunlight. Vitamin D-rich foods includ...

EADV: Cytokine Inhibitor Has High Psoriasis Response (CME/CE)

MedPage Today Dermatology — Mon, 12 Oct 2009 21:22:16 +0100

BERLIN (MedPage Today) -- More than 80% of patients with moderate to severe psoriasis had major responses to an investigational interleukin inhibitor, investigators reported here. (Source: MedPage Today Dermatology)

EADV: Interleukin Inhibitor Works Across Psoriasis Subgroups (CME/CE)

MedPage Today Dermatology — Mon, 12 Oct 2009 20:12:35 +0100

BERLIN (MedPage Today) -- A newly approved cytokine inhibitor demonstrated consistent activity across a range of psoriasis patient subgroups and showed no loss of efficacy in heavier patients with appropriate dosing, according to data reported here. (Source: MedPage Today Dermatology)

EADV: Systemic Psoriasis Therapy Often Delayed (CME/CE)

MedPage Today Dermatology — Mon, 12 Oct 2009 14:10:38 +0100

BERLIN (MedPage Today) -- Patients with psoriasis resistant to topical therapy frequently wait a year or longer to receive systemic therapy, investigators reported here. (Source: MedPage Today Dermatology)