MedWorm: Sleep Disorders

Accidents and close call situations connected to the use of mobile phones.

Accident; Analysis and Prevention. — Wed, 08 Feb 2012 21:35:17 +0100

Authors: Korpinen L, Pääkkönen R Abstract The aim of our work was to study the accidents and close call situations connected to the use of mobile phones. We have analyzed how the accidents/close call situations are connected to background information, in particular age, gender and self-reported symptoms. The study was carried out as a cross-sectional study by posting the questionnaire to 15,000 working-age Finns. The responses (6121) were analyzed using the logistic regression models. Altogether 13.7% of respondents had close call situations and 2.4% had accidents at leisure, in which the mobile phone had a partial effect, and at work the amounts were 4.5% and 0.4% respectively, during the last 12 months. Essentially, we found that: (1) men tend to have more close calls and acci...

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Reliability of simulator driving tool for evaluation of sleepiness, fatigue and driving performance.

Accident; Analysis and Prevention. — Wed, 08 Feb 2012 21:21:29 +0100

CONCLUSIONS: In healthy subjects, the INRETS-MSIS SIM2 simulator appropriately measures driving impairment in terms of inappropriate line crossings related to extended wakefulness but has limitations to measure the impact of extended driving on drivers' performance. PMID: 22269557 [PubMed - in process] (Source: Accident; Analysis and Prevention.)

Memantine as an Augmentation Therapy for Anxiety Disorders

Anesthesiology Research and Practice — Wed, 08 Feb 2012 12:16:29 +0100

Conclusion. The NMDA receptor antagonist memantine may be an effective augmentation therapy in patients with treatment-resistant anxiety. (Source: Anesthesiology Research and Practice)

Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in Rats

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

Previous results demonstrated that 10 Hz electroacupuncture (EA) of Anmian acupoints in rats during the dark period enhances slow wave sleep (SWS), which involves the induction of cholinergic activity in the caudal nucleus tractus solitarius (NTS) and subsequent activation of opioidergic neurons and μ-receptors. Studies have shown that different kinds of endogenous opiate peptides and receptors may mediate the consequences of EA with different frequencies. Herein, we further elucidated that high-frequency (100 Hz)-EA of Anmian enhanced SWS during the dark period but exhibited no direct effect on rapid eye movement (REM) sleep. High-frequency EA-induced SWS enhancement was dose-dependently blocked by microinjection of naloxone or κ-receptor antagonist (nor-binaltorphimine) i...

Parental depressive symptoms and children’s sleep: the role of family conflict

Journal of Child Psychology and Psychiatry — Tue, 07 Feb 2012 14:06:06 +0100

Conclusions: Findings build on this scant literature and highlight the importance of identifying pathways of risk and familial and environmental influences on children’s sleep problems. (Source: Journal of Child Psychology and Psychiatry)

The relationship between breastfeeding and weight status in a national sample of Australian children and adolescents

BMC Public Health - Latest articles — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Breastfeeding for 6 or more months appears to be protective against later overweight and obesity in this population of Australian children. The beneficial short-term health outcomes of breastfeeding for the infant are well recognised and this study provides further observational evidence of a potential long-term health outcome and additional justification for the continued support and promotion of breastfeeding to six months and beyond. (Source: BMC Public Health - Latest articles)

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Efficacy and Safety of Dextromethorphan/Quinidine at Two Dosage Levels for Diabetic Neuropathic Pain: A Double‐Blind, Placebo‐Controlled, Multicenter Study

Pain Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions. Throughout a 13‐week trial, DMQ was effective, with an acceptable safety profile, for treatment of DPN pain. Other fixed‐dose combinations of DMQ should be studied to improve overall tolerability while maintaining significant efficacy. (Source: Pain Medicine)

Beware of Binaural Therapy?

Dr. Weil Q and A — Tue, 07 Feb 2012 03:50:00 +0100

I recently bought a CD for sleep therapy. On the front of the label there's a warning stating that you should consult with your physician before using to ensure you do not have any condition or ailment that may respond negatively to the sonic effects (monaural or binaural beats) contained in the recording. What does this mean? (Source: Dr. Weil Q and A)

Merck Has Positive Results With New Insomnia Drug

Health News from Medical News Today — Mon, 06 Feb 2012 20:00:00 +0100

Merck has announced positive results in a phase 3 trial of its insomnia drug. It's a key player in the companies up and coming products, especially considering the loss of patent protection on its top drugs for asthma and allergys. The experimental drug known as suvorexant, uses a new mechanism created to help people sleep, but at the same time aiming to mitigate side effects associated with popular sleep aids. Analysts think that annual sales of the drug could top $500 million within several years. Peter S... (Source: Health News from Medical News Today)

Pain Negatively Affects Cognition in FibromyalgiaPain Negatively Affects Cognition in Fibromyalgia

Medscape Today Headlines — Mon, 06 Feb 2012 18:15:26 +0100

Pain decreased mathematical abilities and attention control more than depression, anxiety, fatigue, sleep complaints, or medication use. Medscape Medical News (Source: Medscape Today Headlines)

Parenting after Traumatic Events: Ways to Support Children

Psych Central — Mon, 06 Feb 2012 14:35:07 +0100

One of the most important messages for parents about traumatic experiences—such as car accidents, medical trauma, exposure to violence, disasters—that may impact them and their children is that while children of all ages can be impacted, most are resilient and able to cope and recover. Dr. Ann Masten from the University of Minnesota wrote in the journal American Psychologist (2001) about resilience as “ordinary magic.” That is, given normal protective factors, most children will be able to cope, recover, and be fine after witnessing or experiencing a traumatic event. Some children and adolescents may develop symptoms following a disaster, especially if they have experienced traumatic events earlier such as losses or other difficult situations. The symptoms related to trauma may ap...

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Global sleep quality as a moderator of alcohol consumption and consequences in college students. - Kenney SR, LaBrie JW, Hummer JF, Pham AT.

SafetyLit: All (Unduplicated) — Mon, 06 Feb 2012 11:54:53 +0100

The authors examined the relationship between global sleep quality and alcohol risk, including the extent to which global sleep quality moderated the relationship between alcohol use and drinking-related consequences. Global sleep quality was measured usin... (Source: SafetyLit: All (Unduplicated))

Achondroplasia

MedicineNet Sleep General — Mon, 06 Feb 2012 07:00:00 +0100

Title: AchondroplasiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 2/6/2012 (Source: MedicineNet Sleep General)

Fair to bring future scientists and engineers to UC Riverside

EurekAlert! - Medicine and Health — Mon, 06 Feb 2012 05:00:00 +0100

(University of California - Riverside) What are you really eating when youre eating chicken? Do different types of wood produce the same heat when burned? Do twins have similar fingerprints? How does sleep affect your memory? Does your eye color matter? Hundreds of K-12 students from 33 local schools will answer these and other intriguing questions at the 23nd annual Science and Engineering Fair at the University of California, Riverside, Feb. 7-9. (Source: EurekAlert! - Medicine and Health)

Adenosine and Glutamate Signaling in Neuron–Glial Interactions: Implications in Alcoholism and Sleep Disorders

Alcoholism: Clinical and Experimental Research — Mon, 06 Feb 2012 05:00:00 +0100

Recent studies have demonstrated that the function of glia is not restricted to the support of neuronal function. Especially, astrocytes are essential for neuronal activity in the brain. Astrocytes actively participate in synapse formation and brain information processing by releasing or uptaking gliotransmitters such as glutamate, d‐serine, adenosine 5′‐triphosphate (ATP), and adenosine. In the central nervous system, adenosine plays an important role in regulating neuronal activity as well as in controlling other neurotransmitter systems such as GABA, glutamate, and dopamine. Ethanol (EtOH) increases extracellular adenosine levels, which regulates the ataxic and hypnotic/sedative (somnogenic) effects of EtOH. Adenosine signaling is also involved in the homeostasis of major inhibito...

Clinical outcomes of traditional chinese medicine compound formula in treating sleep-disordered breathing patients.

The American Journal of Chinese Medicine — Mon, 06 Feb 2012 03:06:02 +0100

In conclusion, the TCM compound formula based on SZ + NUH could be a safe and effective option for SDB treatment. PMID: 22298445 [PubMed - in process] (Source: The American Journal of Chinese Medicine)

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Gender differences in link between sleep and hypercholesterolemia

MedWire News - Lipidology — Mon, 06 Feb 2012 00:00:00 +0100

Results from a US study suggest that there are significant gender differences in the association between sleep duration and hypercholesterolemia. (Source: MedWire News - Lipidology)

Zolpidem: Nocturnal sleep-related eating disorder: case report

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

(Source: Reactions)

Sleep Troubles May Up Prostate Cancer Risk

MedPage Today Psychiatry — Sat, 04 Feb 2012 13:13:09 +0100

SAN FRANCISCO (MedPage Today) -- Severe sleep problems suggestive of insomnia are associated with an increased risk of prostate cancer among older men, researchers found. (Source: MedPage Today Psychiatry)

In Preadolescence, Sleep Deprivation Tied To Increased Nighttime Urination

Health News from Medical News Today — Sat, 04 Feb 2012 08:00:00 +0100

Nighttime visits to the bathroom are generally associated with being pregnant or having an enlarged prostate, but the problem can affect youngsters, too. A new study sheds light on why some children may need to urinate more often during the rest cycle. Danish researchers have found that sleep deprivation causes healthy children, between the ages of eight and twelve, to urinate significantly more frequently, excrete more sodium in their urine, have altered regulation of the hormones important for excretion, and have higher blood pressure and heart rates... (Source: Health News from Medical News Today)

A case-control study of craniofacial features of children with obstructed sleep apnea.

Sleep and Breathing — Sat, 04 Feb 2012 05:00:00 +0100

CONCLUSIONS: The case group differed from the control group in the length of mandible, anterior lower facial height, position of hyoid and the chin, and the size of the As and T/Ps. PMID: 22302200 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)

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Role of leptin as antioxidant in obstructive sleep apnea: an in vitro study using electron paramagnetic resonance method

Sleep and Breathing — Fri, 03 Feb 2012 17:11:08 +0100

Conclusion Leptin is an antioxidant agent of possible use as a marker of OS and future risk of atherosclerotic disease in OSA. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s11325-012-0656-8Authors Madalina Macrea, Salem VA Medical Center, affiliate of the University of Virginia School of Medicine, Charlottesville, VA, USAThomas Martin, Salem VA Medical Center, affiliate of the University of Virginia School of Medicine, Charlottesville, VA, USALeon Zagrean, Physiology Department, “Carol Davila” School of Medicine, Bucharest, RomaniaZhenquan Jia, Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27410, USAHara Misra, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research, Black...

Well Blog: Think Like a Doctor: Sleeping Wife Solved!

NYT Health — Fri, 03 Feb 2012 17:06:33 +0100

Readers solve the mystery of a 43-year-old healthy and active woman who suddenly falls asleep and can't be awakened. (Source: NYT Health)

Knowledge, Opinions, and Practices of Infant Sleep Position Among Parents

Military Medicine — Fri, 03 Feb 2012 12:18:15 +0100

(Source: Military Medicine)

Twitter is harder to resist than cigarettes and alcohol, study finds

Guardian Unlimited Science — Fri, 03 Feb 2012 10:37:01 +0100

People are more likely to give in to urge to tweet or check email than other cravings, say US researchersTweeting or checking emails may be harder to resist than cigarettes and alcohol, according to researchers who tried to measure how well people could resist their desires.They even claim that while sleep and sex may be stronger urges, people are more likely to give in to longings or cravings to use social and other media.A team headed by Wilhelm Hofmann of Chicago University's Booth Business School say their experiment, using BlackBerrys, to gauge the willpower of 205 people aged between 18 and 85 in and around the German city of Würtzburg is the first to monitor such responses "in the wild" outside a laboratory.The results will soon be published in the journal Psychological Science.The...

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Using questionnaires to assess the quality of life and multidimensionality of fibromyalgia patients

Revista Brasileira de Reumatologia — Fri, 03 Feb 2012 10:19:07 +0100

CONCLUSIONS: All instruments had good discriminating power (P < 0.05), especially FIQ, VAS and PSI, whose areas under the ROC curve were greater (Source: Revista Brasileira de Reumatologia)

Link Between Sleep Apnea And Silent Strokes, Small Lesions In Brain

Health News from Medical News Today — Fri, 03 Feb 2012 09:00:00 +0100

People with severe sleep apnea may have an increased risk of silent strokes and small lesions in the brain, according to a small study presented at the American Stroke Association's International Stroke Conference 2012. "We found a surprisingly high frequency of sleep apnea in patients with stroke that underlines its clinical relevance as a stroke risk factor," said Jessica Kepplinger, M.D., the study's lead researcher and stroke fellow in the Dresden University Stroke Center's Department of Neurology at the University of Technology in Dresden, Germany... (Source: Health News from Medical News Today)

A case–control study of craniofacial features of children with obstructed sleep apnea

Sleep and Breathing — Fri, 03 Feb 2012 07:22:04 +0100

Conclusions The case group differed from the control group in the length of mandible, anterior lower facial height, position of hyoid and the chin, and the size of the As and T/Ps. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s11325-011-0636-4Authors Jinrong Deng, 3rd dental centre, School and Hospital of Stomatology, Peking University, Beijing, ChinaXuemei Gao, Department of Orthodontics, School and Hospital of Stomatology, Peking University, 22 Zhongguancun Nandajie, Haidian District, Beijing 100181, China Journal Sleep and BreathingOnline ISSN 1522-1709Print ISSN 1520-9512 (Source: Sleep and Breathing)

Clayton Sleep Institute Adds AASM Home Testing Accreditation

PRWeb: Medical Pharmaceuticals — Fri, 03 Feb 2012 06:24:02 +0100

CSI continues national, regional leadership in sleep medicine(PRWeb January 31, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9152498.htm (Source: PRWeb: Medical Pharmaceuticals)

Sleep Quality and Sleepiness in Persons with Implantable Cardioverter Defibrillators: Outcome from a Clinical Randomized Longitudinal Trial

Pacing and Clinical Electrophysiology : PACE — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions:Low sleep quality and daytime sleepiness are found at time of insertion and over time in patients with ICD. Female gender, higher NYHA class, as well as two latent factors encompassing increased anxiety, depressive symptoms, and decreased physical function and increased pain, were significant predictors of poor sleep quality and sleepiness over time. These data help identify those at higher risk for sleep problems after ICD.(PACE 2012;00:1–13) (Source: Pacing and Clinical Electrophysiology : PACE)

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Rapid Assessment of Sleep-Wake Behavior in Mice

Journal of Biological Rhythms — Fri, 03 Feb 2012 05:00:00 +0100

Sleep is a fundamental biological rhythm involving the interaction of numerous brain structures and diverse neurotransmitter systems. The primary measures used to define sleep are the electroencephalogram (EEG) and electromyogram (EMG). However, EEG-based methods are often unsuitable for use in high-throughput screens as they are time-intensive and involve invasive surgery. As such, the dissection of sleep mechanisms and the discovery of novel drugs that modulate sleep would benefit greatly from further development of rapid behavioral assays to assess sleep in animal models. Here is described an automated noninvasive approach to evaluate sleep duration, latency, and fragmentation using video tracking of mice in their home cage. This approach provides a high correlation with EEG/EMG measure...

Exploring Sleepiness and Entrainment on Permanent Shift Schedules in a Physiologically Based Model

Journal of Biological Rhythms — Fri, 03 Feb 2012 05:00:00 +0100

The effects of permanent shift work on entrainment and sleepiness are examined using a mathematical model that combines a model of sleep-wake switch in the brain with a model of the human circadian pacemaker entrained by light and nonphotic inputs. The model is applied to 8-hour permanent shift schedules to understand the basic mechanisms underlying changes of entrainment and sleepiness. Average sleepiness is shown to increase during the first days on the night and evening schedules, that is, shift start times between 0000 to 0700 h and 1500 to 2200 h, respectively. After the initial increase, sleepiness decreases and stabilizes via circadian re-entrainment to the cues provided by the shifts. The increase in sleepiness until entrainment is achieved is strongly correlated with the phase dif...

Sleep Apnea Linked to Silent Strokes, Small Lesions in Brain

MedlinePlus Health News — Fri, 03 Feb 2012 01:30:28 +0100

Source: American Heart Association Related MedlinePlus Pages: Sleep Apnea, Stroke (Source: MedlinePlus Health News)

High Rate of Sleep Apnea in Patients With Silent StrokesHigh Rate of Sleep Apnea in Patients With Silent Strokes

Medscape Today Headlines — Thu, 02 Feb 2012 20:22:42 +0100

A new study finds half of patients with clinically silent stroke and a third of those with microvascular changes have sleep apnea. Medscape Medical News (Source: Medscape Today Headlines)

Markers of Sleep Disordered Breathing and Diabetes Mellitus in a Multiethnic Sample of US Adults: Results from the National Health and Nutrition Examination Survey (2005–2008)

Advances in Pharmacological Sciences — Thu, 02 Feb 2012 18:35:24 +0100

We examined gender and ethnic differences in the association between sleep disordered breathing (SDB) and diabetes among 6,522 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2005–08. SDB severity was defined based on an additive summary score including sleep duration, snoring, snorting, and daytime sleepiness. We found that the summary SDB score was significantly associated with diabetes after adjusting for potential confounders in the whole population. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of diabetes among those with ≥3 sleep disturbances was 2.04 (1.46–2.87). In sex-specific analyses, this association was significant only in women (OR (95% CI) = 3.68...

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Duloxetine/fluvoxamine: Sweating, weight gain, restlessness and sleep disturbances: 6 case reports

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

Zolpidem: Sleep driving: case report

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

The pathogenesis of early retinal changes of diabetic retinopathy

Documenta Ophthalmologica — Thu, 02 Feb 2012 18:16:47 +0100

Abstract Recent successful trials of antibodies to vascular endothelial growth factor (VEGF) in diabetic retinopathy implicate this cytokine as a major cause of diabetic retinopathy (DR) and diabetic macular oedema (DME). The mechanisms which cause VEGF to be over-expressed to cause the vasculopathy are not entirely clear. This review explores the earliest changes to the retina in DR and the factors that predispose or prevent DR, including sleep apnoea, receptor degenerations laser treatment and VEGF polymorphism. The review also presents the evidence that retinal hypoxia, existing in the earliest stages, causes DR. This hypoxia is much increased by dark adaptation, indicating a new and possibly superior therapy. Content Type Journal ArticleCategory Review ArticlePages...

Polysomnography underestimates altered cardiac autonomic control in patients with obstructive sleep apnea

Herzschrittmachertherapie und Elektrophysiologie — Thu, 02 Feb 2012 18:14:29 +0100

Conclusion The effect of sleep-disordered breathing on alteration of autonomic tone in patients with hypopnea and obstructive apnea is more severe than estimated by conventional polysomnographic assessment of apnea and hypopnea. Patients with sleep apnea show a sympathetic overdrive not only during phases of hypopnea and obstructive apnea but also in non-apnea, non-hypopnea intervals before and after hypopnea, and obstructive apnea. Content Type Journal ArticleCategory Original ContributionPages 1-7DOI 10.1007/s00399-012-0166-1Authors C. Jilek, Clinic and Policlinic of Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyJ. Gebauer, Clinic and Policlinic of Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyF. Muders, Clini...

Obstructive pressure peak: a new method for differentiation of obstructive and central apneas under auto-CPAP therapy

Sleep and Breathing — Thu, 02 Feb 2012 18:13:56 +0100

Conclusions The analysis of the pressure characteristics of APAP treatment with the registration of OPP allows a further differentiation in obstructed and not obstructed upper airways. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s11325-012-0657-7Authors K. H. Ruhle, Department of Pneumology, HELIOS Clinic Ambrock, Ambrockerweg 60, 58091 Hagen, GermanyU. Domanski, Department of Pneumology, HELIOS Clinic Ambrock, Ambrockerweg 60, 58091 Hagen, GermanyG. Nilius, Department of Pneumology, HELIOS Clinic Ambrock, Ambrockerweg 60, 58091 Hagen, Germany Journal Sleep and BreathingOnline ISSN 1522-1709Print ISSN 1520-9512 (Source: Sleep and Breathing)

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Sleepy Teens

Psychology Today Parenting Center — Thu, 02 Feb 2012 18:01:31 +0100

Can't get your teen out of bed to go to school? Maybe the problem isn't him. Maybe the problem is his changing body.read more (Source: Psychology Today Parenting Center)

Treatment for Veterans with Obstructive Sleep Apnea

Disabled World — Thu, 02 Feb 2012 16:49:21 +0100

United States military veterans now have the option to use Provent Sleep Apnea Therapy, a small, non-invasive nasal device for the treatment of obstructive sleep apnea (OSA). (Source: Disabled World)

“I Can’t Believe Someone Would Do That!” Why Parents Get Mad at Other Parents.

Psychology Today Parenting Center — Thu, 02 Feb 2012 15:10:49 +0100

Why do people get angry about other people's parenting decisions? On the surface, it does not really make sense. Typically, we get angry when we are provoked, when we think we have been treated unfairly, and when we feel we have been harmed. So why would anyone care if another parent lets his or her child play with food at the dinner table? read more (Source: Psychology Today Parenting Center)

Sleep Hygiene: Tips on Getting a Restful Night's Sleep

Psychiatric Times — Thu, 02 Feb 2012 12:00:00 +0100

You snooze, you definitely don't lose. (Source: Psychiatric Times)

'Wake-Up' Stroke Patients Can Be Treated Safely With Clot-Busting Drugs

Health News from Medical News Today — Thu, 02 Feb 2012 09:00:00 +0100

Clot-busting drugs may be safe for patients who wake up experiencing stroke symptoms, according to preliminary research presented at the American Stroke Association's International Stroke Conference 2012. In "wake-up" stroke, the person wakes up with symptoms after going to sleep with none. Not knowing when the stroke began excludes these patients from anti-clotting drugs that must be given within 4.5 hours of the beginning of the stroke... (Source: Health News from Medical News Today)

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imipramine, Tofranil, Tofranil-PM

MedicineNet Sleep General — Thu, 02 Feb 2012 07:00:00 +0100

Title: imipramine, Tofranil, Tofranil-PMCategory: MedicationsCreated: 7/23/1998Last Editorial Review: 2/2/2012 (Source: MedicineNet Sleep General)

Clot-Busting Drug May Work for Those Who Have Strokes While Asleep

MedicineNet Sleep General — Thu, 02 Feb 2012 07:00:00 +0100

Title: Clot-Busting Drug May Work for Those Who Have Strokes While AsleepCategory: Health NewsCreated: 2/1/2012 4:06:00 PMLast Editorial Review: 2/2/2012 (Source: MedicineNet Sleep General)

Sleep Apnea Linked to Silent Strokes

eMedicineHealth.com — Thu, 02 Feb 2012 07:00:00 +0100

(Source: eMedicineHealth.com)

Sleep Apnea Ups Risk of Silent Strokes and Brain Lesions

Medical Headlines From Ivanhoe.com — Thu, 02 Feb 2012 05:00:00 +0100

(Ivanhoe Newswire) – Here’s an eye-opener for those suffering from severe sleep apnea. (Source: Medical Headlines From Ivanhoe.com)

A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan

The Laryngoscope — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions:Our genetic association study, followed by functional and quantitative phenotyping assays, demonstrated a functional locus within the HCRT gene, which may act to increase HCRT expression and lead to a protective effect against the development of OSAS. (Source: The Laryngoscope)

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Impact of repeated daily exposure to intermittent hypoxia and mild sustained hypercapnia on apnea severity

Journal of Applied Physiology — Thu, 02 Feb 2012 05:00:00 +0100

We examined whether exposure to intermittent hypoxia (IH) during wakefulness impacted on the apnea/hypopnea index (AHI) during sleep in individuals with sleep apnea. Participants were exposed to twelve 4-min episodes of hypoxia in the presence of sustained mild hypercapnia each day for 10 days. A control group was exposed to sustained mild hypercapnia for a similar duration. The intermittent hypoxia protocol was completed in the evening on day 1 and 10 and was followed by a sleep study. During all sleep studies, the change in esophageal pressure (Pes) from the beginning to the end of an apnea and the tidal volume immediately following apneic events were used to measure respiratory drive. Following exposure to IH on day 1 and 10, the AHI increased above baseline measures (day 1: 1.95 &plusm...

Compensatory responses to upper airway obstruction in obese apneic men and women

Journal of Applied Physiology — Thu, 02 Feb 2012 05:00:00 +0100

Defective structural and neural upper airway properties both play a pivotal role in the pathogenesis of obstructive sleep apnea. A more favorable structural upper airway property [pharyngeal critical pressure under hypotonic conditions (passive Pcrit)] has been documented for women. However, the role of sex-related modulation in compensatory responses to upper airway obstruction (UAO), independent of the passive Pcrit, remains unclear. Obese apneic men and women underwent a standard polysomnography and physiological sleep studies to determine sleep apnea severity, passive Pcrit, and compensatory airflow and respiratory timing responses to prolonged periods of UAO. Sixty-two apneic men and women, pairwise matched by passive Pcrit, exhibited similar sleep apnea disease severity during rapid ...

Obstructive pressure peak: a new method for differentiation of obstructive and central apneas under auto-CPAP therapy.

Sleep and Breathing — Thu, 02 Feb 2012 05:00:00 +0100

CONCLUSIONS: The analysis of the pressure characteristics of APAP treatment with the registration of OPP allows a further differentiation in obstructed and not obstructed upper airways. PMID: 22302201 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)

Central apnea after adenotonsillectomy in childhood: case report.

Sleep and Breathing — Thu, 02 Feb 2012 05:00:00 +0100

Authors: de Almeida LA, Eckeli AL, Lima WT, de Oliveira Filho EC, Sander HH, Fernandes RM, Valera FC PMID: 22297578 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)

Cough and dyspnoea may discriminate allergic and infectious respiratory phenotypes in infancy

Pediatric Allergy and Immunology — Thu, 02 Feb 2012 05:00:00 +0100

To cite this article: Rancière F, Clarisse B, Nikasinovic L, Just J, Momas I. Cough and dyspnoea may discriminate allergic and infectious respiratory phenotypes in infancy. Pediatr Allergy Immunol 2012: doi: 10.1111/j.1399‐3038.2011.01257.x.AbstractAsthma symptoms are non‐specific during infancy, making the identification of different subgroups among preschool children with early respiratory manifestations an important challenge. We previously used a clustering approach to identify bronchial obstructive phenotypes in 1‐yr‐old infants from the Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort. In the present study, we examined whether these phenotypes were stable at 3 yr and studied their comorbidity and risk factors. Partitioning around medoids (PAM) method was app...

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Sleep apnea may make people more prone to silent strokes

L.A. Times - Health — Wed, 01 Feb 2012 22:55:00 +0100

Almost all (91 percent) of the study participants who had a stroke also had sleep apnea. They were also more likely to have silent strokes as well as white matter lesions on their brains. (Source: L.A. Times - Health)

Sleep Apnea Common in Stroke (CME/CE)

MedPage Today Cardiovascular — Wed, 01 Feb 2012 22:26:32 +0100

NEW ORLEANS (MedPage Today) -- Sleep apnea was found in a large percentage of those who'd suffered a stroke, but it's unclear whether the relationship is causal, according to results of a small study. (Source: MedPage Today Cardiovascular)

Sleep Apnea Linked To Silent Strokes

WDSU.com - Health — Wed, 01 Feb 2012 18:11:02 +0100

This week, a study was presented at the American Stroke Association's International Stroke Conference that adds further evidence that obstructive sleep apnea (OSA) is linked with a high risk of having silent strokes. (Source: WDSU.com - Health)

Severity of depression and anxiety in obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology — Wed, 01 Feb 2012 17:12:47 +0100

Abstract Obstructive sleep apnea (OSA) is a common sleep disorder which can result in mood problems. The aim of this study was to evaluate the severity of depression and anxiety symptoms as the most prevalent psychological disturbances present in different severity of OSA. We performed a cross-sectional study of 685 recently diagnosed sleep-disordered patients, over the age of 18, referred to Noor Sleep Lab from August 2008 to November 2010. The participants filled the Beck depression inventory-II (BDI-II) and the Beck anxiety inventory (BAI) to assess the depression and anxiety symptoms. We collected other characteristics of subjects such as age, sex, body mass index (BMI) and Epworth sleepiness scale (ESS). Apnea hypopnea index (AHI) was determined by an overnight polyso...

Central apnea after adenotonsillectomy in childhood: case report

Sleep and Breathing — Wed, 01 Feb 2012 17:12:46 +0100

Content Type Journal ArticleCategory Case ReportPages 1-6DOI 10.1007/s11325-011-0634-6Authors Leila Azevedo de Almeida, Department of Neuroscience and Behavioral Sciences—Neurology Division, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, BrazilAlan Luiz Eckeli, Department of Neuroscience and Behavioral Sciences—Neurology Division, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, BrazilWilma Terezinha Anselmo Lima, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes, 3900, CEP: 14048-900 Ribeirão Preto, SP, BrazilEdgard Camilo de Oliveira Filho, Cardiology Division, Ribeirão Preto School of Medicine, University...

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Sleep Apnea May Be Tied to ‘Silent’ Strokes, Study Finds

The Doctors Lounge - Cardiology — Wed, 01 Feb 2012 15:00:00 +0100

Other research also suggests rapid memory loss may be linked to a fatal brain attack (Source: The Doctors Lounge - Cardiology)

Dementia and sleep disturbances

Future Medicine: Aging Health — Wed, 01 Feb 2012 14:53:36 +0100

Aging Health , February 2012, Vol. 8, No. 1, Pages 65-78. (Source: Future Medicine: Aging Health)

Sleep Apnea May Be Tied to 'Silent' Strokes, Study Finds

MedlinePlus Health News — Wed, 01 Feb 2012 14:00:00 +0100

Other research also suggests rapid memory loss may be linked to a fatal brain attack Source: HealthDay Related MedlinePlus Pages: Sleep Apnea, Stroke (Source: MedlinePlus Health News)

Biological Time-Keeper Linked To Diabetes

Health News from Medical News Today — Wed, 01 Feb 2012 08:00:00 +0100

Researchers in Lille and Paris demonstrated that mutations in the melatonin receptor gene (melatonin or the "hormone of darkness" induces sleep) lead to an almost sevenfold increase in the risk of developing diabetes. This research, which was published in Nature Genetics on 29 January 2012, could contributed to the development of new drugs for the treatment or prevention of this metabolic disease. Type 2 diabetes is characterised by excess blood glucose and increased resistance to insulin... (Source: Health News from Medical News Today)

Sleep Apnea May Be Tied to 'Silent' Strokes, Study Finds

MedicineNet Cholesterol General — Wed, 01 Feb 2012 07:00:00 +0100

Title: Sleep Apnea May Be Tied to 'Silent' Strokes, Study FindsCategory: Health NewsCreated: 2/1/2012 10:06:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Cholesterol General)

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DiBa: A Data-Driven Bayesian Algorithm for Sleep Spindle Detection

IEEE Transactions on Biomedical Engineering — Wed, 01 Feb 2012 05:00:00 +0100

Although the spontaneous brain rhythms of sleep have commanded much recent interest, their detection and analysis remains suboptimal. In this paper, we develop a data-driven Bayesian algorithm for sleep spindle detection on the electroencephalography (EEG). The algorithm exploits the Karhunen–Loève transform and Bayesian hypothesis testing to produce the instantaneous probability of a spindle’s presence with maximal resolution. In addition to possessing flexibility, transparency, and scalability, this algorithm could perform at levels superior to standard methods for EEG event detection. (Source: IEEE Transactions on Biomedical Engineering)

Sleep apnea linked to silent strokes, small lesions in brain

EurekAlert! - Medicine and Health — Wed, 01 Feb 2012 05:00:00 +0100

(American Heart Association) People with severe sleep apnea may have an increased risk of silent strokes and small lesions in the brain, according to a small study presented at the American Stroke Association's International Stroke Conference 2012. (Source: EurekAlert! - Medicine and Health)

Sleep deprivation tied to increased nighttime urination in preadolescence

EurekAlert! - Medicine and Health — Wed, 01 Feb 2012 05:00:00 +0100

(American Physiological Society) Study sheds light on why some children may need to urinate more often during the rest cycle. Researchers found sleep deprivation caused healthy children, ages 8-12, to urinate significantly more frequently, excrete more sodium in urine, and have altered regulation of the hormones important for excretion. (Source: EurekAlert! - Medicine and Health)

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Sleep Apnea Linked to Silent Strokes

WebMD Health — Wed, 01 Feb 2012 05:00:00 +0100

A common sleep disorder is associated with an increased risk of symptomless, but serious, strokes called “silent strokes,” German researchers report. (Source: WebMD Health)

SLEEP AID (Diphenhydramine Hydrochloride) Tablet [Publix Super Markets Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SLEEP AID (Diphenhydramine Hydrochloride) Tablet [HyVee Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SLEEP AID (Diphenhydramine Hydrochloride) Tablet [Medicine Shoppe International Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SMART SENSE NIGHTIME SLEEP AID (Diphenhydramine Hydrochloride) Tablet [Kmart Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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SLEEP AID (Diphenhydramine Hydrochloride) Tablet [Meijer Distribution Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTHY ACCENTS NIGHTTIME SLEEP AID (Diphenhydramine Hydrochloride) Tablet [DZA Brands LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GOOD SENSE NIGHTTIME SLEEP AID (Diphenhydramine Hydrochloride) Tablet [L Perrigo Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Watch PAT in the diagnosis of obstructive sleep apnea: Influence of aging

The Laryngoscope — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion:Beside the good agreement confirmed between PSG and Watch PAT data in each group, aging did not negatively impact Watch PAT recorded data in terms of included parameters, except the difference in ΔPSG‐Watch PAT of sleep stage 3, which may be attributable to aging and impaired vascular tone. (Source: The Laryngoscope)

Prevalence, Patterns, and Persistence of Sleep Problems in the First 3 Years of Life

PEDIATRICS — Wed, 01 Feb 2012 05:00:00 +0100

Sleep problems are common during childhood, but screening for sleep problems in the clinic setting is often cursory. Moreover, there are few longitudinal studies examining the prevalence and persistence of sleep problems in young children. Patterns of sleep problems vary across early development, but sleep problems arising in infancy persist in 21% of children through 36 months of age. Parent response to a nonspecific query about sleep problems may overlook relevant sleep symptoms and behaviors. (Read the full article) (Source: PEDIATRICS)

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Hip pain while using lower extremity joints is associated with sleep disturbances in elderly caucasian women: The study of osteoporotic fractures

Arthritis Care and Research — Wed, 01 Feb 2012 05:00:00 +0100

Conclusion:Fragmented sleep was greater in women with hip pain compared to those without hip pain. However, fragmented sleep in women with severe hip pain compared to those without hip pain was unchanged until after the first two hours of sleep. Further investigation, such as pain medications wearing off over time, or prolonged periods of inactivity decreasing the pain threshold are warranted. © 2012 by the American College of Rheumatology. (Source: Arthritis Care and Research)

Subjective sleep quality in urban population.

Archives of Iranian Medicine — Wed, 01 Feb 2012 05:00:00 +0100

CONCLUSION: The prevalence rate of sleep complaints in this population-based study was high. Females, older adults, widows and separated couple were the most important risk factors for sleep disturbances. PMID: 22292580 [PubMed - in process] (Source: Archives of Iranian Medicine)

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