MedWorm: Accutane

3 Cases of Dissecting Cellulitis of the Scalp Treated With Adalimumab: Control of Inflammation Within Residual Structural Disease [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:43:14 +0100

Conclusions Adalimumab is effective for treatment of DCS. Relapse on discontinuation of therapy can be expected depending on persisting structural disease. Continuous treatment or combined surgical resection of involved areas could be necessary for definitive resolution of disease.Published online March 15, 2010 (doi:10.1001/archdermatol.2010.16). (Source: Archives of Dermatology)

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Treatment of Epidermal Growth Factor Receptor Antagonist-Induced Skin Rash: Results of a Survey among German Oncologists.

Onkologie — Fri, 12 Mar 2010 12:28:05 +0100

Conclusions: The results of the present analysis illustrate that grading and treatment of EGFR antagonistinduced skin toxicities are very heterogeneous. Clearly, more randomized trials and a simple and reliable grading system are warranted. PMID: 20215799 [PubMed - as supplied by publisher] (Source: Onkologie)

Systemic isotretinoin in the treatment of rosacea – doxycycline- and placebo-controlled, randomized clinical study

JDDG — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions: Isotretinoin 0.3 mg/kg is an effective and well-tolerated therapy option for the treatment of rosacea subtype II and III and can therefore be used successfully as an alternative to therapy with oral antibiotics. (Source: JDDG)

The effect of isotretinoin treatment on plasma homocysteine levels in acne vulgaris

Clinical And Experimental Dermatology — Mon, 08 Mar 2010 00:00:00 +0100

Isotretinoin has revolutionized the treatment of acne by improving the cosmetic outcome and decreasing the psychological damage. However, use of isotretinoin is associated with significant side-effects such as mucocutaneous involvement, dyslipidaemia and liver dysfunction, as indicated by increases in liver enzymes. The responsible enzyme for homocysteine metabolism, cystathionine-[beta]-synthase, might also be affected by isotretinoin-induced liver dysfunction, which leads to hyperhomocysteinaemia, an independent risk factor for thrombovascular diseases. The aim of this study was to evaluate homocysteine levels and the responsible vitamins for its metabolism in patients with moderate to severe acne vulgaris on isotretinoin treatment, before and after treatment. We found increased level of...

AMNESTEEM (Isotretinoin) Capsule [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 05 Mar 2010 05:00:00 +0100

Updated Date: Mar 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Accutane label warns of severe skin reactions

Reactions — Mon, 01 Mar 2010 14:50:10 +0100

(Source: Reactions)

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Facial porokeratosis: A series of six patients

Australasian Journal of Dermatology — Tue, 23 Feb 2010 00:00:00 +0100

We present six cases of facial porokeratosis seen over a period of 15 years in a hospital in Lima, Peru. In most of the cases, porokeratosis was found in younger women without any significant past medical history. Oral isotretinoin showed moderate improvement in two of our patients. (Source: Australasian Journal of Dermatology)

ACCUTANE (Isotretinoin) Capsule, Liquid Filled [Hoffmann-La Roche Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 18 Feb 2010 05:00:00 +0100

Updated Date: Feb 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Jury Awards $25 Million in Damages to US Man Over Side Effects of Accutane

Drugs.com - Pharma News — Wed, 17 Feb 2010 12:29:10 +0100

From Canadian Press DataFile (February 17, 2010) ATLANTIC CITY, N.J. -- A New Jersey jury has hit the pharmaceutical company that makes Accutane with a $25.16 million judgment in a lawsuit filed by an Alabama man who blamed the drug for... (Source: Drugs.com - Pharma News)

New Jersey Jury Awards $25.16 Million To Patient Whose Use Of Roche Acne Medication Accutane Found To Cause Severe Bowel Illness

Pharmaceutical Online News — Wed, 17 Feb 2010 08:42:00 +0100

In another major courtroom verdict linking powerful acne medication Accutane with long-term inflammatory bowel disease (IBD), a nine-person New Jersey jury has found that pharmaceutical maker Hoffman-La Roche Inc. failed to provide an adequate warning of the possible condition to Andrew McCarrell's prescribing physician, which then led to his development of chronic IBD. (Source: Pharmaceutical Online News)

Paxil Birth Defect Litigation - First Trial A Bust for Glaxo

NaturalNews.com — Wed, 17 Feb 2010 07:00:00 +0100

(NaturalNews) GlaxoSmithKline has paid out close to $1 billion to resolve lawsuits involving Paxil since the drug came on the market in1992, according to a December 14, 2009 Bloomberg report. But the billion dollars does not cover the more than 600 Paxil birth defect cases currently pending in multi-litigation in Pennsylvania.Glaxo has settled about 10 birth defect cases, according to Sean Tracey, a Houston attorney who represented the family of a child victim in the first jury trial that decided in favor of the plaintiff on October 13, 2009, Bloomberg reports. The settlements in those lawsuits averaged about $4 million, people familiar with the cases told the new service. First Trial A Bust for GlaxoThe first trial, in the case of Kilker v Glaxo, ended with a jury in Philadelphia finding ...

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Dermabrasion for Acne Scars During Treatment with Oral Isotretinoin

Dermatologic Surgery — Wed, 17 Feb 2010 00:00:00 +0100

Oral isotretinoin is the criterion standard treatment for severe inflammatory acne associated with scar development. Atypical or exaggerated cicatrization related to oral isotretinoin was reported throughout the 1980s and 1990s. Dermabrasion for atrophic acne scar revision is not recommended 6 to 12 months from the end of oral isotretinoin treatment. To evaluate wound healing after localized dermabrasion in patients receiving oral isotretinoin. Interventional, prospective study involving seven patients taking oral isotretinoin to treat acne and with atrophic acne scars on the face. Manual dermabrasion was performed on all patients in an area of approximately 1 cm2, and a 6-month reepithelization follow-up by clinical evaluation was conducted. All patients presented normal cicatrization evo...

Accutane linked to severe skin reactions

CBC | Health — Tue, 16 Feb 2010 19:26:31 +0100

Rare but potentially deadly skin reactions have been found in people using Accutane to treat severe acne, Health Canada says. (Source: CBC | Health)

Acne drug can cause rare but severe skin reactions

CTV Health — Tue, 16 Feb 2010 18:36:54 +0100

Health Canada is advising consumers that rare but potentially deadly skin reactions have been reported with the use of Accutane for the treatment of severe acne. (Source: CTV Health)

Onset of Kleine-Levin Syndrome in association with isotretinoin treatment

Acta Paediatrica — Tue, 16 Feb 2010 00:00:00 +0100

Conclusions: In light of a documented potential of retinoids to modulate sleep-wake regulation, the present case suggests that isotretinoin may rarely trigger the onset of KLS. (Source: Acta Paediatrica)

Isotretinoin: Premature ventricular contractions: case report

Reactions — Mon, 15 Feb 2010 14:06:03 +0100

(Source: Reactions)

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Isotretinoin Use May Increase the Risk for IBD

Internal Medicine News — Mon, 15 Feb 2010 00:00:00 +0100

SAN DIEGO — Isotretinoin use was associated with a 68% increased risk for subsequent development of inflammatory bowel disease, particularly ulcerative colitis, in a retrospective case-control study of 30,021 patients. (Source: Internal Medicine News)

Isotretinoin: Perioral abscess: case report

Reactions — Wed, 10 Feb 2010 14:08:42 +0100

(Source: Reactions)

Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne

The Journal of Dermatology — Wed, 03 Feb 2010 00:00:00 +0100

Acne is a very widespread cosmesis problem. Isotretinoin, a synthetic oral retinoid is used to treat acne, which is androgen dependent. Numerous side-effects occur from this treatment. 5-[alpha]-Reductase plays a critical role in normal and pathological androgen-dependent processes. We have taken the approach to develop a selective, effective, topically-applied 5-[alpha]-reductase inhibitor to modify unwanted or pathological processes in the pilosebaceous unit such as acne. Toward this goal, we have previously developed a selective liposome hair follicle targeting system. We demonstrate in this report that the 5-[alpha]-reductase inhibitor N,N-diethyl-4-methyl-3-oxo-4-aza-5[alpha]-androstane-17[beta]-carboxamide (4-MA) incorporated into liposomes induces apoptosis and inhibits growth of th...

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?

British Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. (Source: British Journal of Dermatology)

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?

The British Journal of Dermatology — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. PMID: 20128787 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Genetic vulnerability and isotretinoin-induced psychiatric adverse events.

The World Journal of Biological Psychiatry — Fri, 29 Jan 2010 00:00:00 +0100

Authors: Kontaxakis VP, Ferentinos PP, Havaki-Kontaxaki BJ, Papadimitriou GN PMID: 20109108 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)

Isotretinoin: Teratogenesis following in utero exposure?: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Isotretinoin: Ulcerative colitis: case report

Reactions — Wed, 27 Jan 2010 14:05:47 +0100

(Source: Reactions)

Isotretinoin: Cobblestone-like papillae, keratitis and ulcer: case report

Reactions — Mon, 11 Jan 2010 14:23:59 +0100

(Source: Reactions)

Efficacy of low-dose isotretinoin in acne vulgaris

Indian Journal of Dermatology, Venereology and Leprology — Wed, 06 Jan 2010 14:01:46 +0100

Sardana Kabir, Garg Vijay KIndian Journal of Dermatology, Venereology, and Leprology 2010 76(1):7-13Low-dose isotretinoin (0.5 mg/kg/day) is a mode of therapy for mild to moderate grades of acne.We analyzed the various trials of this mode of therapy with or without combination with topical agents.We also statistically analyzed the results, efficacy and relapse rates of standard therapy in comparison with the low-dose therapy. Our analysis of the data revealed that the efficacy and relapse rates of low-dose isotretinoin in mild to moderate grades of acne is comparable with the standard regimen (1 mg/kg/day), which is given in the severe grade of acne vulgaris. Thus, the grade of acne vulgaris should dictate the dose of administration of isotretinoin and the standard dose of 1 mg/kg/day is a...

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Optimal Isotretinoin Dosing For Rosacea Identified

Family Practice News — Fri, 01 Jan 2010 00:00:00 +0100

BERLIN — Isotretinoin could be headed for a new indication as a licensed treatment for rosacea. The workhorse oral retinoid has been used off label to treat challenging cases of rosacea for more than 2 decades. However, Barcelona-based Almirall recently sponsored a successful multicenter randomized trial aimed at earning an indication from regulatory authorities for its branded version of isotretinoin in the treatment of rosacea, Dr. Harald Gollnick said at the annual congress of the European Academy of Dermatology and Venereology. (Source: Family Practice News)

Availability of oral isotretinoin and terbinafine on the Internet

Journal of the American Academy of Dermatology — Thu, 17 Dec 2009 14:02:46 +0100

To the Editor: The recent proliferation of Web sites offering opioids, stimulants, and other commonly abused drugs for sale without a prescription is well documented. However, to our knowledge, the availability of dermatologic medications over the Internet remains unknown. (Source: Journal of the American Academy of Dermatology)

Hormonal therapy for acne: why not as first line therapy? facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne. (Source: Clinics in Dermatology)

The role of isotretinoin in acne therapy: why not as first-line therapy? facts and controversies

Clinics in Dermatology — Thu, 17 Dec 2009 14:02:31 +0100

Abstract: Acne is one of the most prevalent diseases in dermatology: Millions of people worldwide experience this distressing condition. To determine the appropriate therapeutic strategy, there is a strong need for a standardized classification system of acne. The exact molecular mechanism of action of isotretinoin is not completely understood; however, oral isotretinoin targets simultaneously at all major mechanisms of acne pathogenesis. Various mass media reports about the risk of teratogenicity and depression from isotretinoin usage as well as the creation of intense prevention programs have created an obstacle to the use of the most active available drug against acne, presenting isotretinoin as a very dangerous regimen. According to recommendations of several international experts, whi...

Isotretinoin: First report of osteochondral lesions: 2 case reports

Reactions — Tue, 15 Dec 2009 14:08:48 +0100

(Source: Reactions)

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Study Links Isotretinoin to Bowel Disease

Skin and Allergy News — Tue, 01 Dec 2009 00:00:00 +0100

Psychological impact of isotretinoin treatment in patients with moderate and severe acne.

Collegium Antropologicum — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Simić D, Situm M, Letica E, Penavić JZ, Zivković MV, Tomić T Acne patients are subject to different degree of psychosocial distress. The emotional impact of acne vulgaris due to disfigurement caused by the disease is undisputed. Most common reactions to the acne are depression and anxiety. The use of isotretinoin, one of the most effective options in acne treatment, increases depression symptoms. The aim of this study was to investigate the psychological status of the patients with moderate to severe acne and to compare patients treated with isotretinoin with patients treated with vitamin C. A total of 85 patients suffering from acne vulgaris were included in the study. The results of this study do not find a significant correlation between the use of i...

Drugs and dilated cardiomyopathies: a case/noncase study in the French PharmacoVigilance Database

British Journal of Clinical Pharmacology — Tue, 24 Nov 2009 00:00:00 +0100

CONCLUSIONS The present study describes an association between some drugs and reports of dilated cardiomyopathies. This relationship involves not only some already suspected drugs (anthracyclines, antiretrovirals), but also other drugs (antipsychotics, lithium, antidepressants, retinoids) less known to induce such an ADR. Despite the mandatory limits of this kind of study (underreporting, confounding factors . . .), these data represent a pharmacovigilance signal and could contribute to establish further prospective studies in order to confirm such signals. (Source: British Journal of Clinical Pharmacology)

Of Blemishes and Bowels: Isotretinoin and Inflammatory Bowel Disease

Gastroenterology — Mon, 23 Nov 2009 00:00:00 +0100

Bernstein CN, Nugent Z, Longobardi T, Blanchard JF. (University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada). Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol 2009;104:2774–2778. (Source: Gastroenterology)

Ranbaxy recalls over 4,000 cartons of acne drug in US

The Economic Times Healthcare and Biotech News — Fri, 20 Nov 2009 19:07:22 +0100

Ranbaxy Laboratories has initiated a voluntary recall of 4,348 cartons of its best-selling drug Sotret (isotretinoin, 40 mg) used to treat acne in the US, as they are a part of one batch of tablets which were found to be ‘out of specification’. (Source: The Economic Times Healthcare and Biotech News)

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Ranbaxy recalls over 4,000 cartons of acne drug in US

The Economic Times Healthcare and Biotech News — Fri, 20 Nov 2009 19:07:22 +0100

Porokeratosis palmaris et plantaris disseminata or a disseminated late-onset variant of porokeratotic eccrine ostial and dermal ductal nevus (PEODDN) with follicular involvement.

Dermatol Online J — Sat, 07 Nov 2009 22:36:03 +0100

Authors: Hartman R, Rizzo C, Patel R, Kamino H, Shupack JL A 48-year-old woman presented with a four-year history of pruritic, hyperkeratotic, spiny papules that began on her chest and spread to her extremities, groin, palms, face, and scalp where it caused non-scarring alopecia. Histopathologic features included cornoid lamella, which is the hallmark of porokeratosis. However, the patient's constellation of findings does not meet diagnostic criteria for any of the five clinical variants of porokeratosis. Her presentation is most compatible with either porokeratosis palmaris et plantaris disseminata (PPPD), which is a rare variant of punctate porokeratosis that can involve any area of the body or late-onset porokeratotic eccrine ostial and dermal ductal nevus (PEODDN), which is a rare,...

New study may deal final blow to acne drug Accutane

Los Angeles Times - Science — Sat, 07 Nov 2009 08:00:00 +0100

The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne. Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: Los Angeles Times - Science)

New study may deal final blow to acne drug Accutane

L.A. Times - Health — Sat, 07 Nov 2009 05:04:32 +0100

Isotretinoin's Mechanism of Action Explored

Skin and Allergy News — Sun, 01 Nov 2009 00:00:00 +0100

PHILADELPHIA — Isotretinoin appears to derive its effectiveness from increased production of the antimicrobial protein neutrophil-gelatinase associated lipocalin in the skin, reducing sebum levels, and in turn reducing levels of Propionibacterium acnes, according to new data. (Source: Skin and Allergy News)

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ACG: Acne Drug Tied to IBD (CME/CE)

MedPage Today Gastroenterology — Thu, 29 Oct 2009 13:00:25 +0100

SAN DIEGO (MedPage Today) -- Use of the acne medication isotretinoin (Accutane) is associated with an increased risk of inflammatory bowel disease, researchers said here. (Source: MedPage Today Gastroenterology)

Management of acne vulgaris: an evidence-based update

Clinical And Experimental Dermatology — Thu, 22 Oct 2009 23:00:00 +0100

This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with standard topical treatments. Long-term topical tretinoin to prevent nonmelanoma skin cancer in elderly men was associated with higher all-cause mortality, but there is c...

CLARAVIS (Isotretinoin) Capsule [Barr Laboratories Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 20 Oct 2009 05:00:00 +0100

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Roaccutane 10mg, 20mg capsules (isotretinoin) - Revised SPC

NeLM - SPC Changes — Mon, 19 Oct 2009 23:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC - change to section 4.3. In addition to soya, isotretinoin is now also contra-indicated in patients allergic to peanuts. (Source: NeLM - SPC Changes)

Isotretinoin: Unmasking of autoimmune diabetes: case report

Reactions — Mon, 19 Oct 2009 13:04:56 +0100

(Source: Reactions)

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Isotretinoin/anti-GD2 monoclonal antibody interaction: First report of an interaction, leading to hypercalcaemia and osteoblastic lesions in a child: case report

Reactions — Mon, 19 Oct 2009 13:04:56 +0100

(Source: Reactions)

Notes from the 8th International Symposium

Kidney Cancer Association — Wed, 14 Oct 2009 19:57:52 +0100

Patient advocates generously volunteered their time to take notes at the recent 8th International Kidney Cancer Symposium, in Chicago. These notes are intended to capture the essence of this important medical meeting and convey it in a way that is useful to patients, survivors, and their families. The first installment sumarizes the Saturday morning session. Integration of Surgical and Systemic Therapy in Metastatic RCC This session was opened by Dr. Bradley Leibovich who presented two cases on which the audience voted on methods to integrate surgery with systemic treatment interventions. The diversity of responses opened the way to consideration of the three discussions that followed. Dr. Jorge Garcia discussed the role of neoadju...

As many as 68% of Dutch women taking the teratogen isotretinoin may not be concomitantly receiving hormonal contraception

Reactions — Tue, 06 Oct 2009 16:33:26 +0100

(Source: Reactions)

Isotretinoin: Keloids: case report

Reactions — Tue, 06 Oct 2009 16:33:26 +0100

(Source: Reactions)

Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris

Karger Publishers — Tue, 29 Sep 2009 23:00:00 +0100

Case Rep Dermatol 2009;1:49-51 (DOI:10.1159/000236034) (Source: Karger Publishers)

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Idiopathic pustular vulvitis

Clinical And Experimental Dermatology — Mon, 21 Sep 2009 23:00:00 +0100

A 31-year-old woman presented in the 23rd week of her third pregnancy with extremely painful pustular vulvitis, unresponsive to antibiotics. Although the histological findings were was consistent with a diagnosis of hidradenitis suppurativa (HS), bridged comedones, the hallmark of this disease, were absent and there were no dermal sinuses. Incision and drainage of the pustules provided only temporary improvement, which was briefly maintained with oral clindamycin and topical steroids. After the birth, a course of isotretinoin produced almost total clearance, a response not typically found in HS. This patient's condition may represent a variant of HS, and if so, it would be the first case report of de novo HS in pregnancy, but its clinical features and evolution differed so much from those ...

Isotretinoin: Psychiatric disorders: 3 case reports

Reactions — Mon, 21 Sep 2009 16:25:31 +0100

(Source: Reactions)

Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. - Rehn L, Meririnne E, Höök-Nikanne J, Isometsä E, Henriksson M.

SafetyLit: All (Unduplicated) — Sun, 13 Sep 2009 17:20:01 +0100

Objective: To investigate the putative association between isotretinoin treatment and depressive symptoms or suicidal ideation among Finnish male military conscripts. Methods Consecutive acne patients were enrolled into an uncontrolled, prospective 12-week... (Source: SafetyLit: All (Unduplicated))

Isotretinoin: Congenital ear malformation following in utero exposure: case report

Reactions — Mon, 07 Sep 2009 16:24:50 +0100

(Source: Reactions)

Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase – a double-blind, randomized, placebo-controlled study

Journal of Cosmetic Dermatology — Mon, 31 Aug 2009 23:00:00 +0100

Conclusions Compared with placebo, the specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days. (Source: Journal of Cosmetic Dermatology)

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Prescription "Sharing" Among Teens Widespread, Dangerous

Health Behavior News Service — Fri, 28 Aug 2009 12:24:15 +0100

08/10/2009, Journal of Adolescent Health, What if a teenager with acne who is taking Accutane - a drug linked to birth defects - gives some to her friend, who is pregnant but does not yet realize it? Unfortunately, this is a realistic scenario. (Source: Health Behavior News Service)

IBD Causation Expert Again Excluded From Accutane MDL

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 22 Aug 2009 10:35:48 +0100

TAMPA, Fla. - "Re-asserted" general causation testimony by plaintiff expert Dr. Ronald Fogel was excluded from the Accutane multidistrict litigation for a second time on Aug. 11 when a judge found that his opinion that the acne drug causes inflammatory bowel disease (IBD) still overreaches data on which it is based (In Re: Accutane Products Liability, MDL Docket No. 1626, No. 04-md-2523, M.D. Fla., Tampa Div.; See 3/5/09, Page 15). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Generic Accutane Case Remanded In Illinois; Doctor's Joinder Proper

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 22 Aug 2009 10:35:48 +0100

CHICAGO - An Illinois federal judge on Aug. 6 remanded an Accutane case to state court after finding that the plaintiff is a state resident and that two medical co-defendants are not fraudulently misjoined (Stephen Livingston v. Hoffman-La Roche Inc., et al., No. 09-2611, N.D. Ill., Eastern Div.; 2009 U.S. Dist. LEXIS 70242). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Standard guidelines of care: Lasers for tattoos and pigmented lesions

Indian Journal of Dermatology, Venereology and Leprology — Wed, 12 Aug 2009 10:19:22 +0100

Aurangabadkar Sanjeev, Mysore VenkataramIndian Journal of Dermatology, Venereology, and Leprology 2009 75(8):111-126Introduction: Lasers have revolutionized the treatment of pigmentary disorders and have become the mainstay of therapy for many of them. Machines: Though different laser machines are used, Quality-switched (QS) lasers are considered as the gold standard for treatment of pigmented lesions. Proper knowledge of the physics of laser machine, methodology, dosage schedules, etc., is mandatory. Physician Qualification: Laser may be administered by a dermatologist, who has received adequate background training in lasers during postgraduation...

ADRAC is reminding prescribers that isotretinoin has been linked to acquired hearing impairment.

Reactions — Mon, 10 Aug 2009 10:20:04 +0100

(Source: Reactions)

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40% Of US Teenagers Share Diverse Prescription Drugs, With Possibly Dangerous And Even Deadly Consequences

Health News from Medical News Today — Mon, 10 Aug 2009 08:00:00 +0100

Imagine one teenager who has acne giving some Accutane, a prescription medication, to a friend. The friend is pregnant and does not know it yet. Accutane is linked to birth defects. This kind of scenario among adolescents is much more common than people realize in the USA. (Source: Health News from Medical News Today)

Roche Cites New Study Finding Accutane Not Linked To IBD In Users

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 08 Aug 2009 11:10:45 +0100

TAMPA - Hoffman-La Roche Inc. on July 24 notified the federal and New Jersey Accutane courts of a July 21 medical journal article that concluded that it is unlikely that Accutane (isotretinoin) is associated with the development of inflammatory bowel disease (IBD), one of the central claims in the litigation (In Re: Accutane Products Liability, MDL Docket No. 1626, No. 04-md-2523, M.D. Fla., Tampa Div., and In Re: Accutane Litigation, No. 271 MT, Jordan Speisman v. Hoffman-La Roche Inc., No. ATL-L-196-05 MT, Lance Speisman v. Hoffman-La Roche Inc., No. ATL-L-197-05 MT, Kelly Mace v. Hoffman-La Roche Inc., No. ATL-L-199-05 MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Accutane Pull Won't Affect Access to Isotretinoin

Skin and Allergy News — Fri, 31 Jul 2009 23:00:00 +0100

Citing a significant loss of market share, Roche announced that it will cease manufacturing the retinoid Accutane, but dermatologists say that the company's pullout will not affect patients' access to the drug and will not have any impact on the risk management program known as iPledge. (Source: Skin and Allergy News)

Demise of Accutane Won't Affect Access to Isotretinoin

Family Practice News — Fri, 31 Jul 2009 23:00:00 +0100

Citing a significant loss of market share, Roche announced in June that it will cease manufacturing the retinoid Accutane, but dermatologists say that the company's pullout will not affect patients' access to the drug and will not have any impact on the risk management program known as iPledge. (Source: Family Practice News)

Association between oral isotretinoin therapy and unmasked latent immuno-mediated diabetes.

Diabetes Care — Fri, 31 Jul 2009 07:56:25 +0100

Authors: Dicembrini I, Bardini G, Rotella CM PMID: 19638521 [PubMed - in process] (Source: Diabetes Care)

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Accutane Retrial Postponed 1 Week, But Pending Appeal May Put It Off Longer

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 25 Jul 2009 11:08:16 +0100

ATLANTIC CITY, N.J. - The retrial of a New Jersey Accutane inflammatory bowel disease (IBD) case will be postponed by one week to accommodate a defense attorney whose father died, the defense decided July 21 after the Atlantic County Superior Court judge refused a defense request to move the retrial to October or December (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L-1951-03 MT, N.J. Super., Atlantic Co.; See 7/2/09, Page 25). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

N.J. Accutane Plaintiff Again Seeks Exclusion Of Numbers Of Drug Users

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 25 Jul 2009 11:08:16 +0100

ATLANTIC CITY, N.J. - A plaintiff in an Accutane retrial on July 10 asked a New Jersey state trial court to again exclude evidence about the over number of Accutane users - the very issue that sent the case back for retrial (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L:-1951-03, N.J. Super., Atlantic Co.; See 7/2/09, Page 25). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Neuroblastoma: treatment outcome after incomplete resection of primary tumors

Pediatric Surgery International — Sat, 25 Jul 2009 04:20:52 +0100

Conclusions For intermediate risk, conventional chemotherapy appears to be acceptable treatment. However, for high-risk patients, every effort should be made to control residual disease including the use of myeloablative chemotherapy, differentiating agents and immune-modulating agents. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2417-8Authors Suk-Bae Moon, Seoul National University Children’s Hospital Department of Pediatric Surgery Seoul KoreaKwi-Won Park, Seoul National University Children’s Hospital Department of Pediatric Surgery Seoul KoreaSung-Eun Jung, Seoul National University Children’s Hospital Department of Pediatric Surgery Seoul KoreaWoong-Jae Youn, Seoul National University Children’s Hospital Department of Pediat...

[Original articles] Treatment of acne with oral isotretinoin in patients with cystic fibrosis

Archives of Disease in Childhood — Wed, 22 Jul 2009 23:00:00 +0100

Conclusions: Adolescents with cystic fibrosis and acne can be treated with oral isotretinoin. Oral isotretinoin should be considered for adolescents with cystic fibrosis who have acne associated with scarring, acne not clearing with topical and antibiotic treatment, acne associated with depression or severe cystic acne. (Source: Archives of Disease in Childhood)

OBSERVATION: Cyclosporine-Induced Infantile Nodulocystic Acne

Archives of Dermatology — Sun, 19 Jul 2009 23:00:00 +0100

Conclusions Nodulocystic acne may be induced by the use of cyclosporine in children as well as adults. When it occurs, it can be managed with cessation of cyclosporine therapy and treatment with isotretinoin. Because this management approach may influence other outcomes in children with transplants, it is best to treat these patients using a multidisciplinary approach. (Source: Archives of Dermatology)

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Treatment Options For Acne Patients Post Accutane's Withdrawal From US Market

Pharmaceutical Online News — Wed, 15 Jul 2009 08:43:00 +0100

Roche Holding AG, the world's biggest maker of cancer drugs, recently announced the withdrawal of its Accutane acne medicine from the US Market. (Source: Pharmaceutical Online News)

Accutane (Isotretinoin) - updated on RxList

RxList - New and Updated Drug Monographs — Thu, 09 Jul 2009 07:00:00 +0100

Accutane (Isotretinoin) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Acne Drug Accutane No Longer Sold

Medscape Medical News Headlines — Wed, 08 Jul 2009 18:12:56 +0100

Generic versions of the acne drug are still available as isotretinoin. Heartwire (Source: Medscape Medical News Headlines)

Acne Drug Accutane No Longer Sold

WebMD Health — Wed, 08 Jul 2009 05:00:00 +0100

Citing "business reasons" -- declining sales and the cost of defending personal injury lawsuits -- Roche has stopped making Accutane. Generic versions are available. (Source: WebMD Health)

N.J. Accutane Retrial Won't Be Stayed To Allow Appeal

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Tue, 07 Jul 2009 11:07:43 +0100

ATLANTIC CITY, N.J. - The July 27 retrial of a $2.6 million Accutane inflammatory bowel disease (IBD) case will not be stayed so defendant Hoffman-La Roche Inc. can ask the New Jersey Supreme Court to review a trial court order denying its motion to have new experts testify, a state court judge ruled June 24 (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Roche Discontinues Accutane Due To Generic Competition

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Tue, 07 Jul 2009 11:07:43 +0100

NUTLEY, N.J. - Hoffman-La Roche Inc. told the Food and Drug Administration on June 26 that it intends to immediately discontinue production of Accutane brand isotretinoin because competition from generic competitors has dropped its market share to 5 percent. Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Isotretinoin: Hypertriglyceridaemia: case report.

Reactions Weekly — Tue, 07 Jul 2009 10:50:55 +0100

Page: 20 (Source: Reactions Weekly)

Roche stops selling Accutane, can't compete with generics

Modern Medicine — Mon, 06 Jul 2009 23:00:00 +0100

Zurich, Switzerland - Swiss drugmaker Roche Holding AG has decided to stop selling Accutane (isotretinoin), as it has reached the end of its life cycle and cannot compete with generic alternatives, Reuters reports. (Source: Modern Medicine)

Isotretinoin: Hypertriglyceridaemia: case report

Reactions — Mon, 06 Jul 2009 10:49:38 +0100

(Source: Reactions)

Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions.

The Turkish Journal of Pediatrics — Wed, 01 Jul 2009 00:00:00 +0100

We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoring- and the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin. PMID: 19950851 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)

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Looking to the future: Derms foresee changes connected to practice management, science

Modern Medicine — Tue, 30 Jun 2009 23:00:00 +0100

Cosmetic dermatology procedures have dramatically changed the face of dermatology. Accutane, lasers, sunscreens, biologics, fillers and Botox are just a few of the additions made to the specialty's armamentarium throughout the past three decades. (Source: Modern Medicine)

A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.

Yonsei Medical Journal — Mon, 29 Jun 2009 23:00:00 +0100

We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotretinoin are needed. PMID: 19568610 [PubMed - in process] (Source: Yonsei Medical Journal)

Roche stops selling acne drug Accutane

Reuters: Health — Fri, 26 Jun 2009 17:32:39 +0100

ZURICH (Reuters) - Swiss drugmaker Roche Holding AG is no longer selling its acne drug Accutane as it has reached the end of its life cycle and is losing ground to generic alternatives, the company said on Friday. (Source: Reuters: Health)

11th Circuit Upholds Accutane Summary Judgment In Case Involving Congressman's Son

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Fri, 26 Jun 2009 14:31:04 +0100

ATLANTA - The wife of U.S. Rep. Bart Stupak, D-Mich., failed to produce evidence that Hoffman-La Roche Inc. knew or should have known that Accutane could cause suicide without premonitory symptoms, a federal appeals panel ruled June 10 in a case involving the suicide of the couple's son while taking the acne drug (Laurie A. Stupak v. Hoffman-La Roche Inc., et al., No. 07-15980, 11th Cir.; 2009 U.S. App. LEXIS 12482; See 5/15/08.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche Can't Name New Experts In Accutane IBD Retrial

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Fri, 26 Jun 2009 14:31:04 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. on June 12 lost its bid to replace its expert witnesses in an Accutane retrial next month (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L-1951-03-MT, N.J. Super., Atlantic Co.; See 6/4/09.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Isotretinoin: Henoch-Schonlein purpura (first report)?: case report.

Reactions Weekly — Fri, 26 Jun 2009 14:16:20 +0100

Page: 26 (Source: Reactions Weekly)

Isotretinoin: Henoch-Schonlein purpura (first report)?: case report

Reactions — Thu, 25 Jun 2009 07:34:34 +0100

(Source: Reactions)

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate

Journal of the American Academy of Dermatology — Thu, 25 Jun 2009 07:32:12 +0100

This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome. (Source: Journal of the American Academy of Dermatology)

Expression of human neutrophil proteins in acne vulgaris

Journal of the European Academy of Dermatology and Venereology — Sun, 21 Jun 2009 23:00:00 +0100

Conclusion Our current study demonstrates the novel observation that a recently identified antimicrobial peptide, HNP 1[ndash]3, is expressed in neutrophils of acne inflammation but not in uninvolved skin of these patients. These results suggest that HNP 1[ndash]3 may contribute to the development of inflammatory lesions of acne. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

Use of isotretinoin for photoaging

Journal of the European Academy of Dermatology and Venereology — Sun, 21 Jun 2009 23:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

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Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne

Journal of the American Academy of Dermatology — Sun, 14 Jun 2009 23:00:00 +0100

Conclusion: Factors other than CYP26 activity may determine response to isotretinoin in acne. (Source: Journal of the American Academy of Dermatology)

Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts

Journal of the European Academy of Dermatology and Venereology — Thu, 11 Jun 2009 04:00:00 +0100

Conclusion On group level, isotretinoin seems not to be typically associated with treatment-emergent depression or suicidal ideation among young men. However, the possibility that individual patients may be susceptible for mood effects of isotretinoin as a rare idiosyncratic reaction can not be excluded. None declared. (Source: Journal of the European Academy of Dermatology and Venereology)

Current topical and systemic approaches to treatment of rosacea

Journal of the European Academy of Dermatology and Venereology — Mon, 08 Jun 2009 04:00:00 +0100

Rosacea is a common, often overlooked, chronic facial dermatosis characterized by intermittent periods of exacerbation and remission. Clinical subtypes and grading of the disease have been defined in the literature. On the basis of a genetic predisposition, there are several intrinsic and extrinsic factors possibly correlating with the phenotypic expression of the disease. Although rosacea cannot be cured, there are several recommended treatment strategies appropriate to control the corresponding symptoms/signs. In addition to adequate skin care, these include topical and systemic medications particularly suitable for the papulopustular subtype of rosacea with moderate to severe intensity. The most commonly used and most established therapeutic regimens are topical metronidazole and topica...

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

Medical Hypotheses — Sun, 07 Jun 2009 23:00:00 +0100

Summary: The term “Epigenetics” refers to DNA and chromatin modifications that persist from one cell division to the next, despite a lack of change in the underlying DNA sequence. The “epigenome” refers to the overall epigenetic state of a cell, and serves as an interface between the environment and the genome. The epigenome is dynamic and responsive to environmental signals not only during development, but also throughout life; and it is becoming increasingly apparent that chemicals can cause changes in gene expression that persist long after exposure has ceased. Here we present the hypothesis that commonly-used pharmaceutical drugs can cause such persistent epigenetic changes. Drugs may alter epigenetic homeostasis by direct or indirect mechanisms. Direct effects may be caused by...

Accutane Discovery Order Appealed In New Jersey; Judge 'Increasingly Concerned'

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 07 Jun 2009 22:22:10 +0100

TRENTON, N.J. - Hoffman-La Roche Inc. on May 26 sought leave to appeal a trial court order that it immediately turn over Accutane documents and e-mails from six Roche employees after the trial judge said she is "increasingly concerned" about the comprehensiveness of the defendant's discovery efforts (In Re: Accutane Litigation, No. n/a, N.J. Super. App., and No. 271 MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Roche Ordered To Stop 'Intimidating' Questions In Accutane Depositions

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 07 Jun 2009 22:22:10 +0100

ATLANTIC CITY, N.J. - A New Jersey state court judge on May 15 found that Hoffman-La Roche Inc. asked deposition questions in the state's Accutane mass tort litigation that could "intimidate, harass, humiliate, and embarrass" plaintiffs and granted a protective order with a threat of sanctions and disciplinary referral (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

New Jersey Accutane Plaintiff Opposes New Experts Sought By Hoffman-La Roche Inc.

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 07 Jun 2009 22:22:10 +0100

ATLANTIC CITY, N.J. - A plaintiff in a $2.6 million New Jersey state court Accutane case says defendant Hoffman-La Roche Inc. is not entitled to new experts when the verdict was reversed solely because one expert's testimony was disallowed (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L-1951-03, N.J. Super., Atlantic Co.; See 5/21/09, Page 12). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

New Jersey Accutane Plaintiffs Say Case Law Doesn't Warrant JNOV, New Trial

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 07 Jun 2009 22:22:10 +0100

ATLANTIC CITY, N.J. - Plaintiffs who won a $12.5 million Accutane inflammatory bowel disease (IBD) verdict against Hoffman-La Roche Inc. on May 17 opposed a renewed motion for judgment notwithstanding the verdict (JNOV) or a new trial, saying two recent case law decisions don't apply to their case (Kelly Mace v. Hoffman-La Roche Inc., et al., No. ATL-L-199-05, Lance Sager v. Hoffman-La Roche Inc., et al., No. ATL-L-197-05; Jordan Speisman v. Hoffman-La Roche Inc., et al., No. ATL-L-196-05, N.J. Super., Atlantic Co.; See 4/2/09, Page 16). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Money, Happiness, Realtor.com, and Spaniels.

Psychology Today Depression Center — Wed, 03 Jun 2009 10:52:18 +0100

During my study of happiness, I’ve noticed that I often learn more from one person’s highly idiosyncratic experiences than I do from sources that detail universal principles or cite up-to-date studies. There’s something peculiarly compelling and instructive about hearing other people’s happiness stories.Laura Rowley has written extensively on one of the most fascinating, complex issues within the large subject of happiness: the relationship between money and happiness. Her book, Money and Happiness, examines the relationship between money and happiness, and how to spend money to reflect your values. On her popular, engaging Yahoo! Finance column, Money and Happiness, she writes frequently about money and how you can use it to build a happier life – or not. Not o...

Blue light special: ALA-PDT safe, effective tool for treating acne lesions

Modern Medicine — Tue, 02 Jun 2009 04:00:00 +0100

A recent study shows that ALA-PDT can be effective in the treatment of acne and particularly beneficial for inflammatory lesions. This treatment modality offers clinicians a safe and effective tool in treating acne lesions without the worries associated with long-term antibiotic therapy and isotretinoin therapy. (Source: Modern Medicine)

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Tretinoin overdose: a first case report.

Journal of Medical Toxicology — Sun, 31 May 2009 23:00:00 +0100

Conclusion: We believe this to be the first case report of an acute oral overdose of tretinoin. The patient developed diarrhea, but was otherwise asymptomatic. PMID: 19415591 [PubMed - in process] (Source: Journal of Medical Toxicology)

Use of isotretinoin for acne vulgaris.

Pediatric Annals — Sun, 31 May 2009 23:00:00 +0100

Authors: Merritt B, Burkhart CN, Morrell DS PMID: 19588674 [PubMed - in process] (Source: Pediatric Annals)

Roche Wants New Experts In Upcoming Accutane Retrial In New Jersey State Court

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 23 May 2009 05:42:12 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. on May 12 asked the New Jersey Accutane court for permission to designate different experts for an upcoming retrial of an inflammatory bowel disease (IBD) case (Andrew McCarrell v. Hoffman-La Roche Inc., et al, No. ATL-L-1951-03, N.J. Super., Atlantic Co.; See 5/7/09, Page 7). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Accutane Advertising Discovery Limited To Issue Of Statute Of Limitations

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 23 May 2009 05:42:12 +0100

ATLANTIC CITY, N.J. - Accutane maker Hoffman-La Roche Inc. may inquire into plaintiff attorney advertising but only if it plays a role in statute of limitations questions, the judge overseeing New Jersey's Accutane mass tort docket ruled May 7 (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol

British Journal of Dermatology — Wed, 20 May 2009 23:00:00 +0100

Conclusions The metabolism and pharmacokinetics of isotretinoin and its main metabolites are not influenced by ethanol during long-term isotretinoin treatment. After ceasing long-term isotretinoin therapy the recommended period of 1 month for using anticonceptive measures in fertile women seems adequate. (Source: British Journal of Dermatology)

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Novel Management of Isotretinoin-Induced Hypertriglyceridemia in an Adolescent With Severe Acne

Clinical Pediatrics — Wed, 20 May 2009 04:00:00 +0100

(Source: Clinical Pediatrics)

OBSERVATION: A Case of Cutaneous Rosai-Dorfman Disease Refractory to Imatinib Therapy

Archives of Dermatology — Mon, 18 May 2009 04:00:00 +0100

Conclusions Failure of imatinib therapy in our patient may be due to a lack of functioning target molecules, the therapy protocol, or the course of the disease. Cutaneous and systemic variants of Rosai-Dorfman disease may be different clinical entities or at least may respond differently to tyrosine kinase inhibitors. (Source: Archives of Dermatology)

Isotretinoin exposure and pregnancy outcome: an observational study of the Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy

Archives of Gynecology and Obstetrics — Fri, 15 May 2009 05:53:55 +0100

Conclusion Inadvertent isotretinoin exposure during the first 2 weeks post conception does not necessarily require discussion of termination of pregnancy, as the risk of major birth defects appears to be much lower than it becomes beyond this period. Nevertheless, additional efforts are required to improve the effectiveness of contraception while on isotretinoin treatment considering psycho-social aspects such as improved self-confidence, unexpected new partnership and sexual activity and incorrect perception of infertility. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1112-2Authors Christof Schaefer, Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy Pharmakovigilanz- und Beratungszentrum für Embryona...

[Leading articles] Isotretinoin and intestinal inflammation: what gastroenterologists need to know

Gut — Mon, 11 May 2009 04:00:00 +0100

(Source: Gut)

Roche Seeks To Vacate $10.5M Accutane Verdict As Time-Barred

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 10 May 2009 17:46:26 +0100

ATLANTIC CITY, N.J. - Accutane maker Hoffman-La Roche Inc. told a New Jersey appeals court May 4 that it should vacate a $10.5 million inflammatory bowel disease (IBD) verdict because the plaintiff's claim is time-barred (Kamie Kendall v. Hoffman-La Roche, Inc., et al., No. A-002633-08-T3, N.J. Super., App. Div.; See 3/19/09, Page 6). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Isotretinoin: Arthralgia and muscle pain: case report

Reactions — Sun, 10 May 2009 16:18:37 +0100

(Source: Reactions)

Isotretinoin: Arthralgia and muscle pain: case report.

Reactions Weekly — Sun, 10 May 2009 16:16:27 +0100

Page: 25 (Source: Reactions Weekly)

Electronic e-isotretinoin prescription chart: improving physicians' adherence to isotretinoin prescription guidelines.

The Australasian Journal of Dermatology — Thu, 30 Apr 2009 23:00:00 +0100

Authors: Tang MB, Tan ES, Tian EA, Loo SC, Chua SH Oral isotretinoin is a highly effective treatment for refractory nodulocystic acne. However, it can be associated with serious adverse effects such as teratogenicity and hepatitis. Inadequate cumulative dosing may also result in reduced therapeutic efficacy and higher disease relapse. A preliminary audit had previously revealed a poor and inconsistent adherence to local isotretinoin prescribing guidelines by physicians. To achieve greater than 90% adherence to isotretinoin guidelines for all acne patients prescribed systemic isotretinoin at the National Skin Centre, Singapore, key areas and the reasons for non-adherence were identified. A specifically designed 'one-stop' electronic isotretinoin chart was launched within the electronic ...

A 2-week pretreatment with 13-cis-retinoic acid + interferon-α-2a prior to definitive radiation improves tumor tissue oxygenation in cervical cancers

Strahlentherapie und Onkologie — Mon, 27 Apr 2009 05:35:05 +0100

Conclusions Pretreatment with cRA/IFN improves oxygenation of primarily hypoxic cervical cancers. The mechanisms of action remain unclear and further investigation of the combination regimen is recommended. Content Type Journal ArticleCategory OriginalarbeitDOI 10.1007/BF03038294Authors Jürgen Dunst, Martin-Luther-University Halle-Wittenberg Department of Radiotherapy Halle-Wittenberg DeutschlandGabriele Hänsgen, Martin-Luther-University Halle-Wittenberg Department of Radiotherapy Halle-Wittenberg DeutschlandUlf Krause, Martin-Luther-University Halle-Wittenberg Department of Pathology Halle-Wittenberg DeutschlandGlenn Füchsel, Martin-Luther-University Halle-Wittenberg Department of Gynecology Halle-Wittenberg DeutschlandUwe Köhler, University of Leipzig Department ...

Oral isotretinoin, neuropathy and hypovitaminosis A

Clinical And Experimental Dermatology — Sun, 26 Apr 2009 23:00:00 +0100

(Source: Clinical And Experimental Dermatology)

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Electronic e-isotretinoin prescription chart: Improving physicians' adherence to isotretinoin prescription guidelines

Australasian Journal of Dermatology — Wed, 22 Apr 2009 23:00:00 +0100

Oral isotretinoin is a highly effective treatment for refractory nodulocystic acne. However, it can be associated with serious adverse effects such as teratogenicity and hepatitis. Inadequate cumulative dosing may also result in reduced therapeutic efficacy and higher disease relapse. A preliminary audit had previously revealed a poor and inconsistent adherence to local isotretinoin prescribing guidelines by physicians. To achieve greater than 90% adherence to isotretinoin guidelines for all acne patients prescribed systemic isotretinoin at the National Skin Centre, Singapore, key areas and the reasons for non-adherence were identified. A specifically designed 'one-stop' electronic isotretinoin chart was launched within the electronic medical records (EMR) system to address important safet...

Not Satisfied With Win, Roche Wants High Court Review Of All Accutane Trial Issues

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 18 Apr 2009 04:59:20 +0100

ATLANTIC CITY, N.J. - Even though it won a new trial in a $2.6 million Accutane inflammatory bowel disease (IBD) case, defendant Hoffman-La Roche Inc. on April 1 said it wants the New Jersey Supreme Court to review the issues that it lost, saying they could affect more than 500 cases pending in the state's Accutane mass tort docket (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. A-328-07T1, N.J. Super., App. Div.; See 3/19/09, Page 4). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

No JNOV, New Trial In New Jersey Accutane Case, But New Motion OK'd

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Wed, 08 Apr 2009 13:24:01 +0100

ATLANTIC CITY, N.J. - The judge overseeing New Jersey's Accutane mass tort docket on March 25 denied a defense motion for judgment notwithstanding verdict (JNOV) or a new trial in a $12.9 million inflammatory bowel disease (IBD) trial but allowed the defendant to file a new motion in light of a superseding state appeals court decision in another IBD verdict (Kelly Mace v. Hoffman-La Roche Inc., et al., No. ATL-L-199-05 MT, Lance Sager v. Hoffman-La Roche Inc., et al., No. ATL-L-197-05, Jordan Speisman v. Hoffman-La Roche Inc., et al., No. ATL-L-196-05 MT, N.J. Super., Atlantic Co.; See 2/5/09, Page 7). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

New Jersey Accutane Court Orders Roche To Produce E-mail Correspondence

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Wed, 08 Apr 2009 13:24:01 +0100

ATLANTIC CITY, N.J. - New Jersey's Accutane mass tort judge on March 18 ordered defendant Hoffman-La Roche Inc. to produce certain e-mail correspondence sought by plaintiffs after they became suspicious of the low volume of such evidence (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.; See 1/8/09, Page 10). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

$13.6M Accutane Judgment Stayed Pending Appeal

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Wed, 08 Apr 2009 13:24:01 +0100

ATLANTIC CITY, N.J. - New Jersey's Accutane mass tort judge on March 18 stayed enforcement of a $13.6 million inflammatory bowel disease (IBD) judgment pending appeal (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.; See 2/19/09, Page 18). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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$2.6M Accutane IBD Verdict Vacated By Appeals Court, Remanded For New Trial

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 21 Mar 2009 04:16:42 +0100

TRENTON, N.J. - Hoffman-La Roche Inc. will get a second bite at the preemption apple and get a chance to put Accutane's inflammatory bowel disease (IBD) risks in context after a New Jersey state appeals court panel on March 12 vacated a $2.6 million verdict and ordered a new trial (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. A-3280-07T1, N.J. Super., App. Div.; See 7/10/08, Page 10). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Treating Physicians Out As Experts In Accutane Case

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 21 Mar 2009 04:16:42 +0100

ATLANTIC CITY, N.J. - The judge overseeing New Jersey's Accutane docket on March 6 denied a motion by Hoffman-La Roche Inc. to retain treating physicians as experts (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.; See 3/5/09, Page 16). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche Posts $13M Bond After Accutane Judge Denies Stay Pending Appeal

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sat, 21 Mar 2009 04:16:42 +0100

ATLANTIC CITY, N.J. - The judge in a New Jersey Accutane inflammatory bowel disease (IBD) case on March 10 denied a defense motion to stay the judgment and waive bond pending appeal (Kamie S. Kendall v. Hoffman-La Roche Inc., et al., No. ATL-L-8213-05 MT, N.J. Super., Atlantic Co.; See 2/19/09, Page 18). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Bilateral osteochondritis dissecans-like osteochondral lesions in two patients: could isotretinoin be a cause?

Clinical And Experimental Dermatology — Thu, 19 Mar 2009 04:00:00 +0100

Authors: Kus S, Haklar U, Aktas S, Cengizoglu I PMID: 19302588 [PubMed - as supplied by publisher] (Source: Clinical And Experimental Dermatology)

Isotretinoin: Sacroiliitis: 3 case reports

Reactions — Tue, 17 Mar 2009 08:38:10 +0100

(Source: Reactions)

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Isotretinoin: Sacroiliitis: 3 case reports.

Reactions Weekly — Sun, 15 Mar 2009 03:38:56 +0100

Page: 32 (Source: Reactions Weekly)

Confluent and reticulated papillomatosis: favourable response to low-dose isotretinoin

Journal of the European Academy of Dermatology and Venereology — Wed, 11 Mar 2009 04:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Accutane Consumer Fraud Claims Dismissed In New Jersey Isotretinoin Cases

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Mar 2009 10:45:22 +0100

ATLANTIC CITY, N.J. - The judge overseeing New Jersey's Accutane litigation on Feb. 28 dismissed state consumer fraud claims made by all plaintiffs alleging personal injury from generic Accutane but allowed them to amend their complaints to assert consumer fraud claims under their home states' laws (In Re: Accutane Litigation, No. 271 MT, Kathryn Flor v. Mylan Bertek Pharmaceuticals, Inc., et al., No. ATL-L-3795-07, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche Seeks Exclusion Of Accutane IBD Expert's 2nd Causation Opinion

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Mar 2009 10:45:22 +0100

TAMPA, Fla. - Hoffman-La Roche Inc. on Feb. 24 asked the Accutane multidistrict litigation court to again exclude a plaintiffs' general causation expert on inflammatory bowel disease (IBD) because his testimony continues to be deficient (In Re: Accutane Products Liability Litigation, MDL Docket No. 1626, No. 04-md-2523, M.D. Fla., Tampa Div.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche: Defense Expert Pool In Accutane Litigation Is Limited

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Mar 2009 10:45:22 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. said Feb. 24 that it needs to be able to retain treating physicians as experts in New Jersey's consolidated Accutane litigation because "there are very few physicians" who are national leaders in their fields and who are affiliated with teaching institutions in the New York/New Jersey/Philadelphia area (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.; See 2/19/09, Page 20). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Isotretinoin: Central retinal vein occlusion: case report.

Reactions Weekly — Mon, 02 Mar 2009 17:37:33 +0100

Page: 29 (Source: Reactions Weekly)

Isotretinoin: Central retinal vein occlusion: case report

Reactions — Mon, 02 Mar 2009 16:18:41 +0100

(Source: Reactions)

Comparison of dose-related ocular side effects during systemic isotretinoin administration.

European Journal of Ophthalmology — Sun, 01 Mar 2009 05:00:00 +0100

CONCLUSIONS. During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin. PMID: 19253234 [PubMed - in process] (Source: European Journal of Ophthalmology)

iPLEDGE Allegiance to the Pill: Evaluation of Year 1 of a Birth Defect Prevention and Monitoring System

The Journal of Law, Medicine and Ethics — Wed, 25 Feb 2009 05:00:00 +0100

The United States Food and Drug Administration (FDA), in collaboration with pharmaceutical manufacturers, have recently implemented a heavily revised risk-management program for patients on isotretinoin (Accutane), a drug with known and pronounced teratogenic effects. This revised risk management plan places significant burdens on both providers and patients in the hopes of achieving its goal of reducing fetal exposure to isotretinoin. The main focus of this paper is to discuss the burdens of various aspects of the program in relationship to potential corresponding benefits. In particular, we evaluate the pregnancy rates of women on isotretinoin therapy compared with that of the general population and the rate changes based on the risk management programs. Additionally, we investigate whet...

The Brown University Child & Adolescent Psychopharmacology Update — Sun, 22 Feb 2009 10:56:49 +0100

Increased Risk of Sudden Cardiac Death with Typical and Atypical AntipsychoticsTrial of Extended-Release Guanfacine in ADHD Shows Symptom ReductionRay et al. 2009 Study DetailsAcute Placebo Treatment in Adolescent DepressionADHD Drugs and Psychotic Symptoms in Pediatric PatientsPharmacologic Treatments for Pediatric InsomniaRisperidone Dosing in AdolescentsImproved Quality of Life with Isotretinoin (Accutane)Catatonic Schizophrenia and ECTWarning Letter for Divalproex AdvertisingMedwatch Safety ChangesPediatric Exclusivity Labeling Changes (Source: The Brown University Child & Adolescent Psychopharmacology Update)

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Roche Cites New Testimony To Discredit Expert In Bid For New Accutane IBD Trial

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 22 Feb 2009 09:21:08 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. says the author on whom a plaintiff expert relied in an Accutane inflammatory bowel disease (IBD) case subsequently testified that she did not intend to show causation, according to a Feb. 11 reply to its motion for judgment notwithstanding the verdict (JNOV), new trial or remittitur of verdict (In Re: Accutane Litigation, Jordan Speisman v. Hoffman-La Roche Inc., No. ATL-L-196-05 MT, Lance Sager v. Hoffman-La Roche Inc., No. ATL-L-197-05 MT, and Kelly Mace v. Hoffman-La Roche Inc., No. ATL-L-199-05 MT, N.J. Super., Atlantic Co.; See 2/5/09, Page 7). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche Seeks Stay, Bond Relief In $12.3M Accutane IBD Judgment Pending Verdict Appeal

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 22 Feb 2009 09:21:08 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. on Feb. 10 asked a New Jersey state court to stay enforcement of an Accutane inflammatory bowel disease (IBD) judgment that exceeds $12.3 million, pending appeal (Kamie S. Kendall v. Hoffman-La Roche Inc., et al., No. ATL-L-8213-05 MT, N.J. Super., Atlantic Co.; See 2/5/09, Page 7). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

New Jersey Accutane Plaintiffs Suspect Incomplete Disclosure; Seek All E-mails From 6 People

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 22 Feb 2009 09:21:08 +0100

ATLANTIC CITY, N.J. - At the direction of the presiding judge, plaintiffs in New Jersey's Accutane mass tort court on Feb. 10 moved for discovery of all e-mails for six "key" Hoffman-La Roche Inc. employees after the plaintiffs say previous discovery has produced an unusually low amount of electronic correspondence and a pattern of late disclosure (In Re: Accutane Mass Tort Litigation, No. 271, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Roche Wants To Hire Accutane Treating Doctors As Causation Experts

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 22 Feb 2009 09:21:08 +0100

ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. on Feb. 4 asked New Jersey's Accutane court for permission to retain treating physicians as causation experts (In Re: Accutane Litigation, No. 271MT, N.J. Super., Atlantic Co.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Isotretinoin: Thrombocytopenia: case report.

Reactions Weekly — Sun, 15 Feb 2009 12:38:35 +0100

Page: 20 (Source: Reactions Weekly)

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Isotretinoin: Thrombocytopenia: case report

Reactions — Sun, 15 Feb 2009 12:14:34 +0100

(Source: Reactions)

SDEF: FDA iPLEDGE Program Sanctions 30 Physicians

MedPage Today Meeting Coverage — Fri, 13 Feb 2009 20:48:46 +0100

WAILEA, Hawaii (MedPage Today) -- The FDA's iPLEDGE isotretinoin (Accutane) prescription program has entered the penalty phase, and thus far 30 physicians have been barred from prescribing the drug. (Source: MedPage Today Meeting Coverage)

Association between isotretinoin use and central retinal vein occlusion in an adolescent with minor predisposition for thrombotic incidents: a case report

BioMed Central — Tue, 10 Feb 2009 05:00:00 +0100

Conclusion: Isotretinoin use may be associated with sight- and life-threatening thrombotic adverse effects even in young patients with otherwise minimal thrombophilic risk. Physicians should be aware of such potential dangers. (Source: BioMed Central)

'Rebuttable Presumption' Law Doesn't Require Stronger Proof, State Accutane Judge Rules

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Feb 2009 09:10:12 +0100

ATLANTIC CITY, N.J. - New Jersey's rebuttable presumption that drug warnings are adequate does not carry a higher burden of proof, a state judge ruled Jan. 16 in denying summary judgment in 24 cases brought by state plaintiffs (In Re: Accutane Litigation, No. 271, N.J. Super., Atlantic Co.; See 9/18/08, Page 14). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

$1.82M-Plus Interest Added To State Accutane Verdict

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Feb 2009 09:10:12 +0100

ATLANTIC CITY, N.J. - A New Jersey state court judge on Jan. 16 added $1.82 million in prejudgment interest and $2,512 a day in post-judgment interest to a $10.5 million Accutane inflammatory bowel disease (IBD) verdict (Kamie S. Kendall v. Hoffman-La Roche, Inc., et al. , No. ATL-L-8213-05 MT, N.J. Super., Atlantic Co.; See 12/18/08, Page 6). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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Accutane IBD Plaintiffs Say Evidence, Testimony Support $12.9M Jury Verdict

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 08 Feb 2009 09:10:12 +0100

ATLANTIC CITY, N.J. - Three Accutane plaintiffs who last year were awarded $12.9 million by a jury on Jan. 26 opposed a motion for judgment notwithstanding verdict (JNOV) or a new trial sought by defendant Hoffman-La Roche Inc. (Kelly Mace v. Hoffman-La Roche Inc., No. ATL-L-199-05, Lance Sager v. Hoffman-La Roche Inc., No. ATL-L-197-05, and Jordan Speisman v. Hoffman-La Roche Inc., No. ATL-L-196-05, N.J. Super., Atlantic Co.; See 12/18/08, Page 7). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

Isotretinoin overdose: Myalgia, dizziness and xerosis: case report

Reactions — Sun, 01 Feb 2009 06:07:02 +0100

(Source: Reactions)

Isotretinoin overdose: Myalgia, dizziness and xerosis: case report.

Reactions Weekly — Sat, 31 Jan 2009 06:58:40 +0100

Page: 16 (Source: Reactions Weekly)

Acute Acne Flare following Isotretinoin Administration: Potential Protective Role of Low Starting Dose

Dermatology — Tue, 27 Jan 2009 10:55:55 +0100

Dermatology 2009;218:178-180 (DOI:10.1159/000182270) (Source: Dermatology)