MedWorm: Adderall

Can Adults Have ADHD?

Psych Central — Thu, 18 Mar 2010 19:33:15 +0100

Attention deficit disorder is not just a childhood disorder. Adults can be diagnosed with attention deficit disorder (ADHD) as well. Sometimes this is a result of the person’s childhood ADHD progressing into adulthood (up to 70 percent of children will continue to struggle with ADHD as adults). Other times, an adult can either simply never been diagnosed as a child, or develop the disorder later on in life. Adult attention deficit disorder looks a lot like childhood attention deficit disorder. That shouldn’t come as a surprise, since the symptoms are largely the same. If you answer “Yes” to six or more of the below symptoms, you may have adult ADHD: Often fails to give close attention to details or makes careless mistakes in course work, work, or other activities ...

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ADDERALL (Dextroamphetamine Saccharate) Tablet [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 14 Jan 2010 05:00:00 +0100

Updated Date: Jan 14, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Shire, Teva settle Adderall XR litigation

bizjournals.com Health Care:Pharmaceuticals headlines — Wed, 02 Dec 2009 14:42:18 +0100

Shire settled litigation Wednesday with Teva Pharmaceuticals USA Inc. over Shire's supply to Teva of an authorized generic version of Adderall XR. (SHPGY) (TEVA) (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Shire, Teva settle Adderall XR litigation

bizjournals.com Health Care:Biotechnology headlines — Wed, 02 Dec 2009 14:42:18 +0100

Intuniv

About.com Pediatrics — Tue, 24 Nov 2009 00:00:00 +0100

With all of the different ADHD medications that are now available, such as Ritalin, Adderall XR, Focalin XR, Concerta, Vyvanse, and Strattera, etc., it is getting easier to find the right medication for children that have ADHD, both to decrease their ADHD symptoms and to minimize any side effects they may have. Still, having another ADHD medication, such as Intuniv, a new non-stimulant treatment for ADHD, is welcome news for many parents and pediatricians. Related: ADHD Symptoms Vyvanse Concerta ADHD Medications Understanding ADHD Intuniv originally appeared on About.com Pediatrics on Tuesday, December 1st, 2009 at 20:23:51.Permalink | Comment | Email this (Source: About.com Pediatrics)

Shire's drug sales offset Adderall decline

FT.com - Drugs and Healthcare — Fri, 30 Oct 2009 20:46:02 +0100

Falling sales of its now off-patent drug Adderall XR continue to weigh on the speciality pharmaceutical group, although strong growth in sales of new drugs are poised to compensate (Source: FT.com - Drugs and Healthcare)

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An Alternative To Adderall?

PRWeb: Medical Pharmaceuticals — Tue, 27 Oct 2009 15:07:04 +0100

PROFIDERALL Becomes the First and Only 'Cognitive Energy Enhancer' Available Without a Prescription (PRWeb Oct 27, 2009) Read the full story at http://www.prweb.com/releases/2009/10/prweb2828864.htm (Source: PRWeb: Medical Pharmaceuticals)

Nonmedical Prescription Stimulant Use Among a Sample of College Students: Relationship With Psychological Variables

Journal of Attention Disorders — Fri, 16 Oct 2009 00:29:39 +0100

Conclusions: Continued research regarding psychological variables, specific group membership (e.g., fraternity, sorority, athletics), and stimulant acquisition is suggested. Effective prevention and education efforts are needed to help address the nonmedical use of prescription stimulants on college campuses. (J. of Att. Dis. 2009; 13(3) 284-296) (Source: Journal of Attention Disorders)

Shire and Sandoz Settle all Pending Litigation Concerning Adderall XR

Drugs.com - Pharma News — Tue, 13 Oct 2009 19:22:07 +0100

Settlement Ends all Litigation With Generics Over ADDERALL XR(R) PHILADELPHIA, October 13/PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announces that it has settled all pending... (Source: Drugs.com - Pharma News)

Impax rolls out ADHD generic

bizjournals.com Health Care:Health Insurance headlines — Thu, 01 Oct 2009 21:23:28 +0100

Impax Laboratories Inc., coming off a 3-1/2-year-old patent settlement deal with Shire Pharmaceuticals, launched a generic version of Shire’s ADHD drug Adderall XR. (IPXL) (Source: bizjournals.com Health Care:Health Insurance headlines)

Impax rolls out ADHD generic

bizjournals.com Health Care:Biotechnology headlines — Thu, 01 Oct 2009 21:23:28 +0100

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Outcomes after accidental pediatric ingestions of (dextro)amphetamine and methylphenidate

The American Journal of Emergency Medicine — Thu, 24 Sep 2009 16:29:41 +0100

Adderall (Barr Laboratories, Inc, Montvale, NJ) and methylphenidate are prescription amphetamines used in the treatment of attention-deficit/hyperactivity disorder (ADHD) and narcolepsy. The exact mechanism of action of amphetamines in the treatment of ADHD is not known; however, it has been shown to stimulate central nervous system (CNS) activity via blockade of both dopamine and norepinephrine reuptake and by increasing their release into the extraneuronal space. Clinical effects can manifest via CNS stimulation or depression. (Source: The American Journal of Emergency Medicine)

Can a pill really boost brain power?

Guardian Unlimited Science — Sat, 19 Sep 2009 23:01:00 +0100

In America, university students are taking illegally obtained prescription drugs to make them more intelligent. But would you pop a smart pill to improve your performance? Margaret Talbot investigates the brave new world of neuro enhancementA young man I'll call Alex recently graduated from Harvard. As a history major, Alex wrote about a dozen papers a term. He also ran a student organisation, for which he often worked more than 40 hours a week; when he wasn't working, he had classes. Weeknights were devoted to all the schoolwork he couldn't finish during the day, and weekend nights were spent drinking with friends and going to parties. "Trite as it sounds," he told me, it seemed important to "maybe appreciate my own youth". Since, in essence, this life was impossible, Alex began taking Ad...

Sudden Death and Use of Stimulant Medications in Youths [Articles]

Am J Psychiatry — Mon, 31 Aug 2009 23:00:00 +0100

CONCLUSIONS: This case-control study provides support for an association between the use of stimulants and sudden unexplained death among children and adolescents. Although sudden unexplained death is a rare event, this finding should be considered in the context of other data about the risk and benefit of stimulants in medical treatment. (Source: Am J Psychiatry)

suboxone,Klonopin,and adderall

Suboxone Forum — Wed, 12 Aug 2009 22:42:00 +0100

Author: An opiate dependent MD Posted: Wed Aug 12, 2009 11:42 pm Hi, Hope your pain is being controlled with the Suboxone. My addiction (not disease) started when I was put on Percocet after a serious leg operation, and since then have been in chronic pain. At the end of 16 months, I was taking up to 600mg qd of oxycodone, and I'd say that was 10% for the pain and 90% because I was hooked. Long story short, went to rehab, got off the oxy's, 8 months clean, relapsed on Vicodin and went on a binge for about 10 weeks before I decided to get help. Went to a detox facility where they put me on Suboxone and slowly tapered me from 32mg to 2mg in about 10 days. While I was on it, I was shocked at how well my pain was controlled. I decided ...

Shire upbeat in face of generic competition

FT.com - Drugs and Healthcare — Wed, 05 Aug 2009 16:06:33 +0100

Drugmaker confident that new products would compensate for the loss in revenues after generic competitor to bestselling Adderall XR dented sales (Source: FT.com - Drugs and Healthcare)

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Do ADHD Drugs Take a Toll on the Brain?

Scientific American - Official RSS Feed — Wed, 22 Jul 2009 14:00:00 +0100

A few years ago a single mother who had recently moved to town came to my office asking me to prescribe the stimulant drug Adderall for her sixth-grade son. The boy had been taking the medication for several years, and his mother had liked its effects: it made homework time easier and improved her son’s grades.At the time of this visit, the boy was off the medication, and I conducted a series of cognitive and behavioral tests on him. He performed wonderfully. I also noticed that off the medication he was friendly and playful. On a previous casual encounter, when the boy had been on Adderall, he had seemed reserved and quiet. His mother acknowledged this was a side effect of the Adderall. I told her that I did not think her son had attention-deficit hyperactivity disorder (ADHD) and t...

ADHD Drugs Associated with Sudden Death among Kids

Alcohol, Tobacco and Other Drugs News — Fri, 17 Jul 2009 12:40:08 +0100

A study funded by the Food and Drug Administration and the National Institute of Mental Health found an association between children taking stimulant drugs such as Ritalin or Adderall, used to treat attention-deficit hyperactivity disorder (ADHD), and sudden unexplained death. (Source: Alcohol, Tobacco and Other Drugs News)

The Mothers Act Disease Mongering Campaign - Part I

NaturalNews.com — Thu, 16 Jul 2009 07:00:00 +0100

(NaturalNews) The Mothers Act represents the ultimate example of disease mongering at its worst because the eight-year attempt to pass this federal legislation has evolved into profiteering never before exhibited so conspicuously.Disease mongering "is the selling of sickness that widens the boundaries of illness and grows the markets for those who sell and deliver treatments," according to Ray Moyniahan and David Henry in the April 11, 2006 paper in PLoS Med, titled, "The Fight against Disease Mongering." "It is exemplified most explicitly by many pharmaceutical industry -- funded disease-awareness campaigns -- more often designed to sell drugs than to illuminate or to inform or educate about the prevention of illness or the maintenance of health," the authors explain. "Drug companies are ...

Placebo Effects In Caregivers May Change Behavior Of Children With ADHD

ScienceDaily Headlines — Tue, 30 Jun 2009 09:00:00 +0100

Stimulant medications, such as Ritalin and Adderall, are the accepted treatment to stem hyperactivity in children with attention deficit-hyperactive disorder and improve their behavior. Now a recent review of research by pediatric psychologists suggests that such medication, or the assumption of medication, may produce a placebo effect -- not in the children, but in their teachers, parents or other adults who evaluate them. (Source: ScienceDaily Headlines)

Placebo effects in caregivers may change behavior of children with ADHD

EurekAlert! - Social and Behavioral Science — Mon, 29 Jun 2009 04:00:00 +0100

(University at Buffalo) Stimulant medications, such as Ritalin and Adderall, are the accepted treatment to stem hyperactivity in children with attention deficit-hyperactive disorder and improve their behavior. Now a recent review of research by University at Buffalo pediatric psychologists suggests that such medication, or the assumption of medication, may produce a placebo effect -- not in the children, but in their teachers, parents or other adults who evaluate them. (Source: EurekAlert! - Social and Behavioral Science)

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FDA tells parents to keep children on ADHD drugs, despite new evidence of sudden death risks

OrlandoSentinel: Medical Research — Tue, 16 Jun 2009 14:43:00 +0100

Federal health regulators are urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite new evidence from a government-backed study that the stimulants can increase the risk of sudden death. Published Monday in... (Source: OrlandoSentinel: Medical Research)

FDA Urges Caution in Weighing Risks of ADHD Drugs - JEMS.com

JEMS Latest News — Tue, 16 Jun 2009 10:38:35 +0100

WASHINGTON -- The FDA is urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite new evidence that the stimulants can increase the risk of sudden death. A government-backed... (Source: JEMS Latest News)

FDA urges caution in weighing risks of ADHD drugs such as Ritalin, Adderall

OrlandoSentinel: Medical Research — Tue, 16 Jun 2009 04:00:00 +0100

WASHINGTON -- Federal health regulators are urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite new evidence from a government-backed study that the stimulants can increase the risk of sudden death.... (Source: OrlandoSentinel: Medical Research)

FDA urges caution in weighing risks of ADHD drugs

USATODAY.com Health — Mon, 15 Jun 2009 19:45:25 +0100

Federal health regulators are urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite ... (Source: USATODAY.com Health)

FDA Urges Caution In Weighing Risks Of ADHD Drugs

Mon, 15 Jun 2009 17:41:35 +0100

Federal health regulators are urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite new evidence in government-backed study that the stimulants can increase the risk of sudden death. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

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FDA tells parents to keep children on ADHD drugs, despite new evidence of sudden death risks

OrlandoSentinel: Medical Research — Mon, 15 Jun 2009 15:39:00 +0100

WASHINGTON (AP) — Federal health regulators are urging parents to keep their children on attention deficit drugs like Ritalin and Adderall, despite new evidence from a government-backed study that the stimulants can increase the risk of sudden... (Source: OrlandoSentinel: Medical Research)

Sudden Death and Use of Stimulant Medications in Youths.

The American Journal of Psychiatry — Sun, 14 Jun 2009 23:00:00 +0100

Conclusions This case-control study provides support for an association between the use of stimulants and sudden unexplained death among children and adolescents. Although sudden unexplained death is a rare event, this finding should be considered in the context of other data about the risk and benefit of stimulants in medical treatment. PMID: 19528194 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

An update on central nervous system stimulant formulations in children and adolescents with attention-deficit/hyperactivity disorder.

The Annals of Pharmacotherapy — Sun, 31 May 2009 23:00:00 +0100

CONCLUSIONS: Stimulants are effective medications to treat the symptoms of ADHD. The multiple available dosage forms allow for individualization of treatment. PMID: 19470858 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Teens and Drugs

Psychology Today Addiction Center — Thu, 28 May 2009 18:39:00 +0100

Is your son or daughter taking drugs? Not sure? Are you a teen looking for more accurate information? Well... read on.My son once told me he could get anything, meaning any drug, at his high school and this is in Irvine, California which is known for good quality, safe, and academic schools. Another teen told me that private Catholic schools actually have more drugs than inner city schools. And, he knew because he had been to both. And a third teen told me made more connections in rehab than he ever had before going in. Drugs are ubiquitous. Drugs are everywhere.According to the Center for Disease Control (CDC), a very reliable government agency, the most commonly used substances by teens are alcohol and marijuana. Pills, ADHD medications like adderall, cocaine, inhalants, ecstasy, meth, h...

No change in pharmacokinetics of ADHD medication VYVANSE CII when coadministered with Prilosec

EurekAlert! - Social and Behavioral Science — Thu, 21 May 2009 04:00:00 +0100

This study was presented at the International Congress on Clinical Pharmacy, co-sponsored by the American College of Clinical Pharmacy. (Source: EurekAlert! - Social and Behavioral Science)

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Parents Are Drugging Kids For An Academic Edge!

Health News from Medical News Today — Tue, 19 May 2009 09:00:00 +0100

According to a recent article in the New Yorker, college students are taking neurological drugs like Adderall and Ritalin to help them party hard -- while giving them an academic edge. What's even worse is that this trend isn't just occurring in colleges. (Source: Health News from Medical News Today)

College Students More Likely to Misuse Adderall, Study Finds

Alcohol, Tobacco and Other Drugs News — Fri, 10 Apr 2009 17:30:00 +0100

College students between the ages of 18 and 22 were twice as likely to use the amphetamine drug Adderall nonmedically as those who had not been in college at all or were only part-time students, according to data from the National Survey on Drug Use and Health (NSDUH). (Source: Alcohol, Tobacco and Other Drugs News)

Generic version of ADHD drug reaches market early

Modern Medicine — Tue, 07 Apr 2009 04:00:00 +0100

Teva is now selling generic versions of Shire Plc's ADHD drug Adderall XR in the US, years before its patent expires. (Source: Modern Medicine)

Generic version of ADHD drug reaches market early

Modern Medicine Contemporary Pediatrics — Tue, 07 Apr 2009 04:00:00 +0100

Teva is now selling generic versions of Shire Plc's ADHD drug Adderall XR in the US, years before its patent expires. (Source: Modern Medicine Contemporary Pediatrics)

Comprehensive Treatment of Childhood ADHD

Psych Central — Sun, 29 Mar 2009 21:57:46 +0100

While learning of the diagnosis of attention deficit disorder (ADHD) makes many parents feel relief, the real work begins in finding the right treatment approach for a child or teen diagnosed with ADHD. If the diagnosis was made by a pediatrician or family physician, the first thing you should ask for is a referral to a mental health professional trained in the treatment of attention deficit disorder. This should happen before any treatment is prescribed, because, as you’ll learn, the order and focus of treatment is important. Although the inclination may be to start medication treatment immediately (with drugs such as Ritalin or Adderall), you should not give in to this feeling that you need “do something.” Since the diagnosis of ADHD requires the child to have inattent...

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Attention Deficit Hyperactivity Disorder Fact Sheet

Psych Central — Mon, 09 Mar 2009 16:58:17 +0100

Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed disorder in children and teens. Its hallmark symptoms include hyperactivity, inattention and impulsivity. Children have difficulty concentrating, following instructions, sitting still and interacting with others. Some kids may call out answers without waiting their turn and make inappropriate comments. Others might be quiet and keep to themselves, daydreaming away at their desks. ADHD also affects approximately 4 percent of adults, according to the National Institute of Mental Health. These adults have problems with organization, time management, sustaining their attention, completing tasks and controlling their emotions. They can miss deadlines, speak without thinking, get easily distracted, misplace items and...

When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study

Psychopharmacology — Sat, 07 Mar 2009 12:02:14 +0100

Content Type Journal ArticleCategory ErratumDOI 10.1007/s00213-009-1507-6Authors Martha J. Farah, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USACaroline Haimm, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USAGeena Sankoorikal, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USAM. Elizabeth Smith, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USAAnjan Chatterjee, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacol...

The New Illicit Drugs: Kids Who Don't Need Cognitive Enhancers Take Them Anyway

OrlandoSentinel: Medical Research — Wed, 25 Feb 2009 05:00:00 +0100

Becca Hartman is sympathetic to the kids who want her Adderall — prescribed for her attention-deficit disorder — to help them study. But she's becoming less so. "I'm like, 'Don't even go there'" said Hartman, a junior at the University of... (Source: OrlandoSentinel: Medical Research)

ADHD Drugs Cause Hallucinations in Children; Psychiatry Pushes Hallucinogenic Drugs for Profit

NaturalNews.com — Tue, 27 Jan 2009 07:00:00 +0100

(NaturalNews) New research published in the journal Pediatrics reveals that the ADHD drugs prescribed to millions of children are causing them to experience frightening hallucinations. Children on these drugs hallucinated that snakes and bugs were crawling all over them, says Reuters, and some kids taking the drugs experience other bizarre psychotic side effects such as thinking they ran into a wall and falling to the ground even when no wall was present.ADHD drugs, of course, are powerful psychotropic mind-altering chemicals that are often molecularly identical to street drugs. The industry of psychiatry is virtually owned by Big Pharma, which hopes to drug every child, teenager and adult with at least one mind-altering medication.The drugs reviewed in this study include: Ritalin and Foca...

Rhabdomyolysis associated with the nutritional supplement Hydroxycut.

American Journal of Health-System Pharmacy : AJHP — Thu, 15 Jan 2009 05:00:00 +0100

CONCLUSION: An 18-year-old Caucasian man with no significant medical history developed rhabdomyolysis possibly associated with the ingestion of Hydroxycut in addition to his increased exercise regimen. PMID: 19139478 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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ADHD Drugs Don't Cause Genetic Damage

WebMD Health — Wed, 19 Nov 2008 23:35:50 +0100

Ritalin, Adderall, and Concerta do not appear to cause genetic damage in children who take them for attention deficit hyperactivity disorder (ADHD), a new government-funded study concludes. (Source: WebMD Health)

When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study

Psychopharmacology — Sun, 16 Nov 2008 11:30:59 +0100

Conclusion The preliminary evidence is inconsistent with the hypothesis that Adderall has an overall negative effect on creativity. Its effects on divergent creative thought cannot be inferred with confidence from this study because of the ambiguity of null results. Its effects on convergent creative thought appear to be dependent on the baseline creativity of the individual. Those in the higher range of the normal distribution may be unaffected or impaired, whereas those in the lower range of the normal distribution experience enhancement. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-008-1369-3Authors Martha J. Farah, University of Pennsylvania Center for Cognitive Neuroscience 3720 Walnut Street Philadelphia PA 19104 USACaroline Ha...

Study Finds No Income Level Differences in Children Receiving Free Drug Samples, Indicates Samples Could Increase Children's Health Risks

kaisernetwork.org: Health Policy Daily Report — Mon, 06 Oct 2008 05:00:00 +0100

Children from low-income families are no more likely to receive no-cost prescription drug samples than children in families with higher incomes, but no-cost samples that children do receive could put them at risk, according to a study published Monday in the journal Pediatrics, the New York Times reports (Harris, New York Times, 10/6).For the study, the first to examine the effect of no-cost drug samples in children, researchers analyzed data from a 2004 in-depth CDC survey on how U.S. residents received health care. In total, researchers analyzed data from 10,295 U.S. residents younger than age 18. Researchers found that one in 20 U.S. residents younger than age 18 received at least one no-cost drug sample in 2004. Of all U.S. residents younger than age 18 who received a prescribed medica...

Free Drug Samples in the United States: Characteristics of Pediatric Recipients and Safety Concerns

PEDIATRICS — Wed, 01 Oct 2008 04:00:00 +0100

CONCLUSIONS. Poor and uninsured children are not the main recipients of free drug samples. Free samples do not target the neediest children selectively, and they have significant safety considerations. (Source: PEDIATRICS)

Be All That You Can Be, And Then Some

Psychology Today Personality Center — Mon, 15 Sep 2008 20:22:24 +0100

I first took Ritalin in first grade. I went off it soon after but tried it again in high school and have been reliant upon it and other psychoactive medications for the last 14 years--nearly half my life. Do i feel artificial? Do I feel like I'm cheating? Do I feel like I'm not being the real me? Those aren't even questions I ask myself anymore. After much experimentation with various molecules and dosages and life situations, I've made peace with my drug dependence, and now when pondering a prescription refill or an individual pill in my hand, instead of asking which me is the real me--chemically modified or au natural--I ask which me I prefer.Despite the popularity of caffeine and alcohol, not everyone feels the same, and new research (covered in the August issue of Psychology Today) map...

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The Swimming Cure for ADHD?

Psychology Today Parenting Center — Mon, 18 Aug 2008 04:12:28 +0100

Michael Phelps’ amazing Olympic triumph belies the notion of a chronic disorder In the next view days you are certain to read more about Michael Phelp’s childhood including his being diagnosed with ADHD and treated with medication at age nine for two years. A front page New York Times piece on Michael today suggested the diagnosis when his third grade teacher, Mrs. Kines, was quoted in a recent letter to his mother, Debbie, as recalling Michael having “immense difficulties concentrating and sitting still” leading Mrs. Kines to wonder “if he would ever be able to focus on anything.” A quick Google search revealed a July 22nd local Baltimore TV news piece interviewing Debbie about Michael’s ADHD and a FaceBook essay by Debbie about the same subject. Apparently Michael was a ...

Shire increases revenue forecast

FT.com - Drugs and Healthcare — Fri, 01 Aug 2008 00:25:00 +0100

The pharmaceuticals company reports strong second-quarter figures, boosted by sales of its drug Adderall XR, and expects 2008 revenue to rise at least 20% (Source: FT.com - Drugs and Healthcare)

Protein On 'Speed' Linked To ADHD

ScienceDaily Headlines — Thu, 10 Jul 2008 03:00:00 +0100

A genetic change in the dopamine transporter, discovered in two brothers with attention deficit hyperactivity disorder, makes it behave as if amphetamine is present and "run backward," Vanderbilt Medical Center investigators report. The researchers propose that because the altered transporter pushes dopamine out into the synapse, it alters dopamine signaling and contributes to the symptoms of ADHD. They further find that both Ritalin and Adderall, two ADHD medications, block the backward-running transporter. (Source: ScienceDaily Headlines)

The National Center on Addiction and Substance Abuse (CASA) at Columbia University: New CASA* Report Finds: Most Web Sites Selling Prescription Opioids, Stimulants and Depressants Require No Prescription

Market Wire - Pharmaceuticals and Biotech — Wed, 09 Jul 2008 04:01:00 +0100

NEW YORK, NY (MARKET WIRE) Despite a decline in the number of Web sites advertising or selling controlled prescription drugs, like OxyContin and Valium, Xanax and Vicodin, and Ritalin and Adderall, in the past year, 85 percent of Web sites selling such drugs do not require a prescription, according to "'You've Got Drugs!' V: Prescription Drug Pushers on the Internet," the fifth annual White Paper on this subject released by The National Center on Addiction and Substance Abuse (CASA) at Columbia University. (Source: Market Wire - Pharmaceuticals and Biotech)

ADHD Drugs Pose Heart Health Risks to Children

NaturalNews.com — Wed, 25 Jun 2008 07:00:00 +0100

(NaturalNews) Children taking stimulants as a treatment for attention-deficit hyperactivity disorder (ADHD) are 20 percent more likely to visit a doctor with heart-related symptoms, according to a new study conducted by researchers at the University of Florida and published in the journal Pediatrics.Researchers examined the records on 55,000 children between the ages of 3 and 20 who had undergone treatment for ADHD using central nervous system stimulants between 1994 and 2004. Their health profiles were compared with those of nearly two million other children in the Florida Medicaid database, making the current study the largest ever on the safety of ADHD drugs.Children taking stimulants were 20 percent more likely than other children to visit the emergency room or doctor's office with hea...

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Shadow Syndromes and the Crazy Scale: A Cautionary Tale

Psychology Today Personality Center — Sun, 22 Jun 2008 14:23:58 +0100

In the past decade or so mental and behavioral health has enjoyed an insurgence that has transformed it from a sub-discipline of the medical field to nothing less than a juggernaut. This is due in large part to the introduction of SSRIs and MAOIs and the coincident culture of dysfunction, as well as that of overmedication that these treatments have spawned.One of the most consistent questions I am asked is, "What's wrong with me?" More and more, that question comes with a preamble from so-called expert patients armed with all sorts of information they have gathered on their alleged condition. I am consistently reminded that a little knowledge and a lack of perspective is a dangerous thing.This brings to mind my sophomore year Abnormal Psych professor who, in the hallowed, ivy-cov...

Drug Enforcement Administration To Propose Rule To Allow E-Prescribing of Controlled Substances

kaisernetwork.org: Health Policy Daily Report — Fri, 20 Jun 2008 05:00:00 +0100

The Drug Enforcement Administration as early as next week plans to announce a proposed rule that would allow electronic prescribing of medications classified as controlled substances, according to an individual familiar with the situation, the Wall Street Journal reports. The rule, which would require a public comment period, likely will include security requirements to ensure the legitimacy of prescriptions for controlled substances, which account for about 10% to 13% of all U.S. prescriptions.The rule would apply to "Schedule IV" medications -- such as the insomnia treatments Lunesta and Ambien, as well as the anti-anxiety medication Xanax -- and "Schedule V" medications, such as the pain treatment Lyrica. According to an individual familiar with the situation, the rule also would apply ...

National Briefing | Health: Herb Found Ineffective for Disorder

NYT > Health — Wed, 11 Jun 2008 23:07:27 +0100

The herb St. John’s wort does not improve children’s symptoms of attention deficit hyperactivity disorder, according to researchers who tested it as a possible alternative to stimulant drugs used to treat this common condition. A study published in The Journal of the American Medical Association involving 54 children with the disorder ages 6 to 17 found that those given St. John’s wort did no better than those getting a placebo. Millions of children with the disorder are treated with stimulant medications like Ritalin and Adderall. (Source: NYT > Health)

Vyvanse Approved for Adult ADHD

ADHD Medications and Treatments — Wed, 11 Jun 2008 18:15:00 +0100

Vyvanse has been FDA approved for the treatment of ADHD in children aged 6 to 12 since July of 2007. Shire announced on April 23, 2008 that it had received approval from the FDA for the treatment of ADHD in adults. Shire also markets Adderall XR, which also has FDA approval for treatment of adult ADHD.A four week study of 414 adults aged 18 to 55 years old with ADHD found significant improvement in ADHD symptoms after one week. Doses studied were 30 mg, 50 mg, and 70 mg. The Clinical Global Impressions-Improvement scale, used to rate severity of illness and improvement, found that 57 to 61 percent of subjects improved across all doses. The most common side effects were decreased appetite, difficulty falling asleep, and dry mouth, according to Shire.Related Topics:WebMD Video: Managing Adul...

Adderall: Cardiomyopathy: case report

Reactions — Wed, 04 Jun 2008 15:24:07 +0100

(Source: Reactions)

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So, you think we're going to end addiction soon?

Psychology Today Addiction Center — Tue, 03 Jun 2008 17:36:28 +0100

Returning from Ireland, I read Barbara Tuchman's 1978 best selling history, A Distant Mirror: The Calamitous 14th Century. The 14th Century included the Black Death, which killed between a third and two-thirds of Europeans. Authorities could not address the epidemic because they didn't know microbes caused disease. So, instead of improving sewage treatment, people slaughtered Jews.Before we laugh or cry over our benighted forbearers, we should reflect on our own inability to stem a number of tides. The one I am chiefly interested in is addiction. Ireland is currently revising its drug policy. Everyone agrees substance abuse is worse now than when the policy was introduced. But just as clearly as that policy failed, the new policy will contain the same principal ingredients.American policy ...

Hematologic changes associated with Adderall toxicity in a dog.

Veterinary Clinical Pathology — Sun, 01 Jun 2008 04:00:00 +0100

Authors: Wilcox A, Russell KE A 1-year-old intact male Boxer was presented to the Texas Veterinary Medical Center for emergency treatment following suspected ingestion of a large number of tablets of Adderall, a pharmaceutical amphetamine. The dog had a temperature of 41.7 degrees C, heart rate of 192 beats per minute, and a respiratory rate of 100 breaths per minute. The dog was anxious and agitated with bilaterally dilated pupils, and shortly thereafter became recumbent and incontinent. Initial CBC results included mild leukopenia and mild thrombocytopenia. The dog was not anemic (HCT 39.9%) and had only slight polychromasia, but had 48 nucleated RBCs/100 WBC (7500/muL). Moderate numbers of neutrophils had hypersegmented nuclei and several pyknotic cells were noted. The metarubricyto...

Adderall: Cardiomyopathy: case report.

Reactions Weekly — Sat, 31 May 2008 14:50:09 +0100

Page: 5 (Source: Reactions Weekly)

Cardiomyopathy Due to Ingestion of Adderall.

American Journal of Therapeutics — Wed, 21 May 2008 15:25:02 +0100

Page: 287DOI: 10.1097/MJT.0b013e3180ed6291Authors: Marks, Donald H MD, PhD * (Source: American Journal of Therapeutics)

Why scientists should be allowed to take brain-enhancing drugs

Psychology Today Addiction Center — Fri, 18 Apr 2008 08:45:55 +0100

20% of scientists responding to a survey in Nature claimed to have used cognitive-boosting drugs, including Ritalin and Provigil (Modafinil) to enable them to perform better, sleep more efficiently, or increase their concentration or memory. These are the same drugs given daily to millions of children in the US to improve school performance. In most cases it looks like the scientists' use was either illegal or quasi-legal at best. Yet scientists should not have to take these drugs clandestinely. Instead their use should be an open experiment in the advantages and disadvantages of these drugs.The US has been slow to give these drugs a proper screening, partly because it seems to have an all-or-nothing, medically-good or socially-evil approach to drugs. Either a drug is good because it helps...

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Adderall: Weight Loss Fix of the Stars?

ABC News: Health — Tue, 25 Mar 2008 15:57:09 +0100

A growing number of celebrities are reported to be abusing the ADHD drug. (Source: ABC News: Health)

Rebound Effects with Long-Acting Amphetamine or Methylphenidate Stimulant Medication Preparations among Adolescent Male Drivers with Attention-Deficit/Hyperactivity Disorder

Journal of Child and Adolescent Psychopharmacology — Mon, 25 Feb 2008 04:00:58 +0100

This study investigated whether OROS methylphenidate (OROS MPH, Concerta) or extended-release mixed amphetamine salts (se-AMPH ER, Adderall XR) were associated with worsening of driving performance, or drug rebound, relative to placebo 16–17 ... (Source: Journal of Child and Adolescent Psychopharmacology)

History of Excessive Drinking Blocking Treatment in the Community

CounsellingResource.com News and Features — Thu, 31 Jan 2008 11:17:24 +0100

Q: I have recently had suicidal ideations this college semester, possibly a consequence of using Adderall in conjunction with alcohol. I was prescribed Adderall a year ago by my family physician not because of an ADHD diagnosis but rather my complaint of difficulty with anxiety and stress management. His rationale was that by using Adderall [...] (Source: CounsellingResource.com News and Features)

Medications Do Not Necessarily Normalize Cognition in ADHD Patients

Journal of Attention Disorders — Fri, 14 Dec 2007 05:00:00 +0100

Conclusion: Even with optimal treatment, based on parents' and teachers' opinions, subtle and not-so-subtle neurocognitive impairments persisted in the ADHD patients. Some ADHD patients may require additional educational assistance, even in the face of successful medication treatment. (J. of Att. Dis. 2008; 11(4) 459-469) (Source: Journal of Attention Disorders)

School-based administration of ADHD drugs decline, along with diversion, theft, and misuse.

The Journal of School Nursing — Sat, 01 Dec 2007 05:00:00 +0100

Authors: Dupont RL, Bucher RH, Wilford BB, Coleman JJ Since 2000 researchers have reported a decline in the administration of attention-deficit/hyperactivity disorder (ADHD) medications given by school nurses, although no decline has been noted in the incidence of ADHD in school-age populations. Government data for the same period show reduced levels of methylphenidate abuse as measured by its involvement in hospital emergency department (ED) admissions. Offsetting this, however, is an increase in the involvement of amphetamine-dextroamphetamine in hospital ED admissions for the same period. Because ADHD medications are often administered in the school setting, a survey of school nurses was undertaken to identify factors related to the administration as well as to the diversion, theft,...

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Adderall/methylphenidate: Psychodermatological disorders: 4 case reports

Reactions — Wed, 14 Nov 2007 13:56:25 +0100

(Source: Reactions)

Adderall/methylphenidate: Psychodermatological disorders: 4 case reports.

Reactions Weekly — Sat, 10 Nov 2007 01:38:54 +0100

Page: 5 (Source: Reactions Weekly)

Adderall interaction: Interaction with concomitant varenicline leading to reduced efficacy of varenicline: case report

Reactions — Tue, 23 Oct 2007 12:55:41 +0100

(Source: Reactions)

Adderall interaction: Interaction with concomitant varenicline leading to reduced efficacy of varenicline: case report.

Reactions Weekly — Sat, 20 Oct 2007 00:32:02 +0100

Page: 4 (Source: Reactions Weekly)

Adderall Xr(Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate) Capsule, Extended Release [Shire US Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 10 Oct 2007 05:00:00 +0100

Updated Date: Oct 10, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Interference with Smoking-Cessation Effects of Varenicline After Administration of Immediate-Release Amphetamine-Dextroamphetamine

Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy — Thu, 27 Sep 2007 04:00:00 +0100

Pharmacotherapy 27(10): 1440-1445 An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD) was prescribed varenicline for smoking cessation. He quit smoking after 1 week of therapy and remained smoke free for the next 17 days. During that time, he had also been taking amphetamine-dextroamphetamine (Adderall) on work days for his ADHD. Because his supply of amphetamine-dextroamphetamine was diminishing, he took only half (30 mg every morning) of his prescribed dosage from days 4-12 of varenicline therapy. He further reduced his dosage to 15 mg every morning on days 13 and 14 of varenicline therapy, and his supply of amphetamine-dextroamphetamine was depleted on day 15. On day 23 of varenicline therapy, he received and filled a new prescription for amphetamine-dextroamphetamin...

Gore Case Calls Attention to Prescription Drug Abuse

Alcohol, Tobacco and Other Drugs News — Tue, 10 Jul 2007 18:04:09 +0100

The arrest of Al Gore III on charges of illegal possession of marijuana, Adderall, Xanax, Valium and Vicodin is helping to raise awareness about the problem of prescription drug abuse. (Source: Alcohol, Tobacco and Other Drugs News)

Forecasting Three-Month Outcomes in a Laboratory School Comparison of Mixed Amphetamine Salts Extended Release (Adderall XR) and Atomoxetine (Strattera) in School-Aged Children With ADHD

Journal of Attention Disorders — Mon, 02 Jul 2007 04:00:00 +0100

Conclusion: This study suggests that relative advantages of MAS-XR seen in the first 3 weeks are likely to be maintained in subsequent weeks. (J. of Att. Dis. 2007; 11(1) 74-82) (Source: Journal of Attention Disorders)

Recalls and Safety Alerts: Cardiovascular and Psychiatric Risks with ADHD Drugs

Food and Drug Adminstration (FDA): Patient Safety News — Tue, 01 May 2007 04:00:00 +0100

Patients with Attention Deficit Hyperactivity Disorder(ADHD) who are taking stimulant drugs such as Adderall (amphetamine-dextroamphetamine), Ritalin (methylphenidate) and Strattera (atomoxetine hydrochloride) will soon be given a Patient Medication ... (Source: Food and Drug Adminstration (FDA): Patient Safety News)

Differential effects of the d- and l- isomers of amphetamine on pharmacological MRI BOLD contrast in the rat

Psychopharmacology — Tue, 27 Mar 2007 06:53:11 +0100

Conclusions The amphetamine isomers produce different BOLD responses in brain areas related to cognition, pleasure, pain processing and motor control probably because of variations on brain amine systems such as dopamine and noradrenaline. The isomers may, therefore, have distinct actions on brain regions affected in ADHD patients. Content TypeJournal Article JournalPsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

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Adderall abuse in Texas, 1998-2004. - Forrester MB.

SafetyLit: All (Unduplicated) — Sat, 24 Mar 2007 22:44:02 +0100

This study describes the patterns of Adderall abuse calls received by several poison control centers in Texas during 1998-2004. Drug a... (Source: SafetyLit: All (Unduplicated))

Overweight kids, teens treated with ADHD drug

CNN.com - Health — Wed, 21 Mar 2007 18:46:27 +0100

A Chicago doctor's approach to treating overweight children and teens -- prescribing the ADHD drug Adderall -- raises an ethical question: Has the obesity epidemic among children become so severe that it's OK to prescribe a drug not approved for weight loss when the drug can have serious, sometimes life-threatening side effects? (Source: CNN.com - Health)

Shire files patent lawsuit over ADHD drug

bizjournals.com Health Care:Pharmaceuticals headlines — Wed, 21 Mar 2007 18:46:11 +0100

Shire plc filed a patent infringement lawsuit Wednesday against companies that are seeking approval to make a generic version of Shire's Adderall XR drug for attention deficit hyperactivity disorder. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Adderall Caused Boy's Fatal Cardiac Arrest, Mother Alleges

LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News — Sun, 04 Mar 2007 03:20:02 +0100

MINNEAPOLIS, Minn. - The manufacturer of Adderall XR is liable for a 12-year-old boy's Aug. 28, 2002, death from cardiac arrest because the company knew but failed to warn about the risk of sudden cardiac death, the boy's mother says in a Feb. 6 complaint (Carol Mundy v. Shire U.S., No. 07-CV-878, D. Minn.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

FDA Approves New ADHD Drug Vyvanse

ADHD Medications and Treatments — Thu, 01 Mar 2007 05:00:00 +0100

The U.S. Food and Drug Administration approved Vyvanse (lisdexamfetamine dimesylate) for the treatment of ADHD. Vyvance was designed to lower the potential for abuse. Stimulant medications are the first-line treatment for ADHD, but many clinicians are reluctant to prescribe stimulants because they are often misused in our society. However, children and adolescents with untreated ADHD are at an increased risk of developing a problem with substance use, and effective treatment of ADHD significantly decreases that risk.The route of administration of a stimulant has a strong affect on abuse potential. Drugs that are rapidly absorbed and achieve higher blood levels can produce a euphoric effect. This effect is easier to obtain by crushing short acting tablets and snorting or injecting them. Lon...

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SCIENCE DIGEST: FDA: More warnings for ADHD drugs

Life — Thu, 22 Feb 2007 08:01:00 +0100

The makers of Ritalin, Adderall, Strattera and other drugs treating attention deficit hyperactivity disorder were advised by the government Wednesday to give patients and their parents an additional warning that those medicines can cause serious psychiatric and heart problems, including sudden death. (Source: Life)

FDA instructs ADHD drug manufacturers to notify patients about cardiovascular and psychiatric adverse events

NeLM Headline News — Thu, 22 Feb 2007 00:00:00 +0100

The FDA has instructed the manufacturers of ADHD drugs in the US to develop Patient Medication Guides (contain FDA-approved patient information) to warn about possible cardiovascular and psychiatric adverse effects linked to these medicines, and the precautions that can be taken. A review of reports of serious cardiovascular adverse events in patients taking usual doses of ADHD products by the agency found reports of sudden death in patients with underlying serious heart problems or defects, and reports of stroke and heart attack in adults with certain risk factors. Another review indicated a slight increased risk (about 1 per 1,000) for drug-related psychiatric adverse events, such as hearing voices, becoming suspicious for no reason, or becoming manic, even in patients who did not have...

Illicit Use of Specific Prescription Stimulants Among College Students: Prevalence, Motives, and Routes of Administration

Medscape FamilyMedicine Headlines — Fri, 15 Dec 2006 17:00:00 +0100

Anecdotal reports have identified Adderall as the main drug used by students to help them study, but are the stories true? Pharmacotherapy (Source: Medscape FamilyMedicine Headlines)

ORIGINAL ARTICLE: Modeling Sensitization to Stimulants in Humans: An [11C]Raclopride/Positron Emission Tomography Study in Healthy Men

Archives of General Psychiatry — Mon, 04 Dec 2006 07:00:00 +0100

Conclusions Sensitization to stimulants can be achieved in healthy men in the laboratory. This phenomenon is associated with increased dopamine release and persists for at least 1 year. (Source: Archives of General Psychiatry)

Effect of extended release stimulant-based medications on neuropsychological functioning among adolescents with Attention-Deficit/Hyperactivity Disorder.

Archives of Clinical Neuropsychology — Fri, 01 Dec 2006 07:00:00 +0100

Authors: Wilson HK, Cox DJ, Merkel RL, Moore M, Coghill D Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with diminished neuropsychological functioning. This randomized, double-blind, placebo controlled, study is the first comparison of two extended release stimulant-based medications (Adderall XR and Concerta) and placebo on ADHD neuropsychological functioning. Adolescents diagnosed with ADHD (n=35, 19 males) completed three separate assessments (5, 8, 11 p.m.) on three different days and medications (Concerta, Adderall XR and Placebo). The assessments consisted of two different neuropsychological tests, the Delayed Matching-to-Sample and the Go/No-go (GNG), which measure visual memory, attention span, and response inhibition. Results indicated a significant effect of m...

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Shire Analysis Compares Stimulant To Nonstimulant ADHD Medications In Patients Aged 8 To 15 Years

ADHD News From Medical News Today — Thu, 23 Nov 2006 08:00:00 +0100

Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced the results of a study which suggested that stimulant medications such as ADDERALL XR® (mixed salts of a single-entity amphetamine product) are significantly more effective than non-stimulant medications in the treatment of patients aged 8 to 15 with Attention-Deficit/Hyperactivity Disorder (ADHD). [click link for full article] (Source: ADHD News From Medical News Today)

Shire Announces Results Of A Meta-Analysis Comparing Stimulant Medications To Non-Stimulant Medications In Treating ADHD In Patients Aged 8 To 15

ADHD News From Medical News Today — Fri, 17 Nov 2006 08:00:00 +0100

Shire plc (LSE: SHP, Nasdaq: SHPGY, TSX: SHQ) announced the results of a study which suggested that stimulant medications such as ADDERALL XR(R) (mixed salts of a single-entity amphetamine product) are significantly more effective than non-stimulant medications in the treatment of patients aged 8 to 15 with Attention-Deficit/Hyperactivity Disorder (ADHD). [click link for full article] (Source: ADHD News From Medical News Today)

Shire analysis compares stimulant to nonstimulant ADHD medications in patients aged 8 to 15 years

EurekAlert! - Medicine and Health — Fri, 17 Nov 2006 01:15:02 +0100

Shire plc announced study results that suggested that stimulant medications such as Adderall XR (mixed salts of a single-entity amphetamine product) are significantly more effective than nonstimulant medications in the treatment of patients aged 8 to 15 years with Attention-Deficit/Hyperactivity Disorder. The study, a meta-analysis of 29 studies undertaken during the last 25 years with nearly 4,500 children with ADHD, was presented at the US Psychiatric & Mental Health Congress. (Source: EurekAlert! - Medicine and Health)

Shire bioequivalence study results of SPD465, investigational drug for adults with ADHD

EurekAlert! - Medicine and Health — Fri, 17 Nov 2006 01:15:02 +0100

Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced that a single once-daily morning dose of the investigational amphetamine compound SPD465, extended release triple-bead mixed amphetamine salts, designed to reduce symptoms of Attention-Deficit/Hyperactivity Disorder in adults for up to 16 hours, was bioequivalent to a dose of ADDERALL XR (mixed salts of a single-entity amphetamine product) followed by a dose of mixed amphetamine salts immediate release ("MAS IR") eight hours later, at the US Psychiatric & Mental Health Congress. (Source: EurekAlert! - Medicine and Health)

Research Roundup: This week’s papers from Boston labs

Nature Network Boston - Recent News — Fri, 03 Nov 2006 20:54:00 +0100

Spinning a tale of spider silkBy studying the behavior of minute quantities of liquid silk harvested from the spinning glands of the golden silk orb-weaving spider, MIT researchers are unraveling the secrets of this strong and durable material. Their goal is to create synthetic silk, a long-sought prized polymer that could find use in artificial tendons and ligaments, parachutes, and bulletproof vests. The golden silk spider spins one of the strongest webs in the spider world—in some cases, strong enough to catch small birds. Researchers Nikola Kojic and Gareth McKinley and colleagues at MIT set out to study the flow properties of the protein-rich liquid silk in order to see if they could understand how it irreversibly transforms into tough fibers as it exits the spider. But native...

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College Kids Choose Adderall Over Ritalin For Illicit Use

Psychology / Psychiatry News From Medical News Today — Tue, 31 Oct 2006 08:00:00 +0100

More than 75% of college students who reported using prescription stimulants illicitly last year chose amphetamine-dextroamphetamine products, like Adderall, over methylphenidate products, like Ritalin. The study, first-authored by Northeastern University Pharmacy Professor Christian Teter, also found that the primary motives for illicit use were to enhance academic performance, while less than a third of illicit users intended to get high or experiment with these stimulants. [click link for full article] (Source: Psychology / Psychiatry News From Medical News Today)

College Students Popping Prescription Pills -- Reasons Why

Medical Headlines From Ivanhoe.com — Mon, 30 Oct 2006 14:00:00 +0100

Adderall is apparently the stimulant of choice for some college students looking to get ahead. (Source: Medical Headlines From Ivanhoe.com)

FDA Safety Changes: Zanaflex, Adderall, Adderall XR

Medscape PublicHealth Headlines — Thu, 26 Oct 2006 14:58:01 +0100

The FDA has approved revisions to the safety labeling tizanidine HCl and mixed salts of a single-entity amphetamine product. (CME,CE)Medscape Medical NewsLaurie Barclay,Yael Waknine (Source: Medscape PublicHealth Headlines)

October 22, 2006: How ADHD Drugs Work

Sound Medicine — Wed, 25 Oct 2006 10:46:03 +0100

Until recently, doctors did not clearly understand how drugs such as Ritalin and Adderall curb ADHD (attention deficit hyperactivity disorder)... (Source: Sound Medicine)

October 22, 2006: Adderall Abuse

Sound Medicine — Wed, 25 Oct 2006 10:46:03 +0100

Dr... (Source: Sound Medicine)

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ADDERALL XR(R) - Paragraph IV Notice Received

Drug Newswire — Fri, 06 Oct 2006 22:43:11 +0100

BASINGSTOKE, England and PHILADELPHIA, Pennsylvania, October 3/PRNewswire/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) - Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announces that it has received a Paragraph IV notice letter from Andrx Pharmaceuticals, L.L.C. (Andrx) advising of the filing of an Abbreviated New Drug Application... (Source: Drug Newswire)

Barr Cleared to Launch ADDERALL(R) IR

Drug Newswire — Fri, 06 Oct 2006 22:43:11 +0100

Hart-Scott-Rodino Waiting Period Expires Without Comment from Federal Trade Commission WOODCLIFF LAKE, N.J., Sept. 28 /PRNewswire-FirstCall/ -- Barr Pharmaceuticals, Inc. (NYSE:BRL) today announced that the Hart-Scott-Rodino ("HSR") waiting period for the Company's acquisition of Shire plc's ADDERALL(R) (immediate-release mixed amphetamine salts) product has expired without further action from... (Source: Drug Newswire)

Illicit Use of Specific Prescription Stimulants Among College Students: Prevalence, Motives, and Routes of Administration

Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy — Wed, 27 Sep 2006 07:39:01 +0100

Conclusion. Illicit use of amphetamine-dextroamphetamine is more prevalent than illicit use of methylphenidate formulations among college students. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)

Daytrana

ADHD Medications and Treatments — Tue, 29 Aug 2006 15:57:00 +0100

Once-daily preparations of medications used to treat AD/HD have become the standard of care. Concerta (OROS methylphenidate) and Focalin XR (dexmethylphenidate) are effective for about 12 hours, and Adderall XR (extended-release mixed amphetamine salts) is effective for 10 - 12 hours.People with AD/HD have symptoms all day long, but taking medications several times a day, especially at school or at work, is inconvenient, is frequently "forgotten," and can be stigmatizing. Some people taking multiple doses of shorter-acting preparations feel as if they are on an "emotional rollercoaster," with symptoms increasing and decreasing as each dose is wearing off and the next dose is starting to work.AD/HD is a life problem, not a school or work problem, and longer-acting preparations help people t...

New Heart Alert for Some ADHD Drugs

WebMD Health — Tue, 22 Aug 2006 19:00:41 +0100

Amphetamine-based drugs for ADHD, such as Adderall and Dexedrine, now come with a new, expanded black box warning for an increased risk of sudden death in patients with heart problems. (Source: WebMD Health)

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Barr, Shire reach deals on Adderall

United Press International - Health Business — Tue, 15 Aug 2006 15:51:00 +0100

Barr and Shire announced late Monday they have reached an agreement relating to the attention deficit disorder drug Adderall. (Source: United Press International - Health Business)

College students popping Adderall

Life — Wed, 09 Aug 2006 00:19:02 +0100

Some college students who stay up all night to cram for final exams are turning to prescription drugs like Adderall to get what they can't from coffee, energy drinks and No-Doz alone: an energy boost, plus the ability to concentrate longer than their attention spans normally allow. (Source: Life)

AD/HD Medications During Pregnancy

ADHD Medications and Treatments — Mon, 07 Aug 2006 18:57:00 +0100

Since approximately 3 - 5% of the adult population struggles with symptoms related to AD/HD, including women who are planning on having children, there are frequent questions about use of medications during pregnancy. Stimulant medications, including methylphenidate (Ritalin, Concerta, Metadate CD, and others), mixed amphetamine salts (Adderall, Adderall XR), and dextroamphetamine (Dexedrine) remain the first-line medication for treatment of AD/HD. There have been no well-controlled studies of stimulant use during pregnancy (ethically, a study giving a stimulant medications to pregnant women would not be authorized by the FDA). Stimulants are classified as Category C by the FDA (Animal studies show adverse effects, but there are no controlled human studies). Amphetamines (Adderall and Dexe...

Greater Risk Of Accidents In Young Adult Drivers With ADHD

Health News from Medical News Today — Wed, 02 Aug 2006 07:00:00 +0100

A pilot study conducted byresearchers at the Washington Neuropsychological Institute found that asmall group of young adults (n=14) with Attention-Deficit/HyperactivityDisorder (ADHD) improved their driving safety performance when treated withonce-daily Adderall XR(R), a leading ADHD medication. [click link for full article] (Source: Health News from Medical News Today)

Greater Risk Of Accidents In Young Adult Drivers With ADHD

ADHD News From Medical News Today — Wed, 02 Aug 2006 07:00:00 +0100

This study suggeststhe importance of effectively treating ADHD symptoms, as untreated ADHDcompromises road safety by impairing an individual's ability to focus. [click link for full article] (Source: ADHD News From Medical News Today)

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Cardiovascular, Psychiatric Warnings Strengthened on Adderall

ASHP Breaking News — Fri, 28 Jul 2006 13:00:00 +0100

Shire has revised the labeling of its attention-deficit/hyperactivity disorder (ADHD) medications Adderall and Adderall XR to include stronger warnings about psychiatric and cardiovascular risks associated with use of the products. (Source: ASHP Breaking News)

Study shows how ADHD drugs Adderall, Ritalin and Dexedrine work in brain

News-Medical News Feed — Tue, 27 Jun 2006 06:00:00 +0100

Although millions depend on medications such as Ritalin to quell symptoms of attention deficit hyperactivity disorder (ADHD), scientists have struggled to pinpoint how the drugs work in the brain. (Source: News-Medical News Feed)

ADHD Medication Study

dukehealth.org: Duke Clinical Trials — Wed, 21 Jun 2006 06:00:00 +0100

Children ages six to 12 with ADHD who have not been treated before will receive evaluation and three months of treatment with Concerta or Adderall. (Source: dukehealth.org: Duke Clinical Trials)

Health Canada issues new cautions and advice regarding rare heart-related risks for all ADHD drugs

NeLM news - Mental Health — Tue, 30 May 2006 00:00:00 +0100

PharmaLive has reported that Health Canada has revised the prescribing and patient information for all drugs used for the management of ADHD (Attention Deficit Hyperactivity Disorder) and advises that these drugs should not be used by patients who have high blood pressure, heart disease or abnormalities, hardening of the arteries or an overactive thyroid gland. The new prescribing and patient information applies to both adults and children. Standardised labeling that identifies risk factors for rare heart-related side effects, and new recommendations to physicians have been added to the prescribing information for the following drugs, and for any products containing these drugs: • Adderall XR (mixed salts amphetamine extended-release) • Concerta (methylphenidate extended release) • D...

Side Effects, Strattera and Stimulants: The Differences

ADHD Medications and Treatments — Thu, 06 Apr 2006 05:40:00 +0100

StratteraStrattera and imipramine increase norepinephrine in contrast to stimulants that increase dopamine, and potential effectiveness and side effects varies widely between norepinephrine and dopamine drugs.Imipramine is often more effective for hyperactivity and impulsivity than for inattention and distractibility, but only works in about 50% of children and very high doses are often required. High doses are related to cardiac side effects in children, as well as often severe sedation and other side effects.Strattera is generally well-tolerated and has a much greater chance of treating AD/HD. However, unless started at very low doses and then increased only very slowly, many children experience sedation and lethargy. I generally start children on 10 mg doses of Strattera, then after at ...

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"Long-Acting" Stimulants

ADHD Medications and Treatments — Mon, 03 Apr 2006 05:41:00 +0100

In reality, there is no such thing as a "long-acting stimulant." Almost all stimulants are short-acting, including caffeine, nicotine, cocaine, Ritalin, or Adderall.However, manufacturers put short-acting stimulants in various containers (capsules or tablets) that release short-acting medication two or more times a day. Essentially you're getting the same old wine in a different bottle.The Concerta container is much like a capsule with three chambers, two containing methylphenidate (Ritalin) and one an absorbent material. There are laser-drilled holes in the container. As liquid from your GI tract is absorbed into the container, an osmotic plunger pushes the medication out of the holes.Ritalin LA is a capsule that contains beads, half with a coating that dissolves immediately and half with...

Blood Pressure Changes with ADHD Medications

ADHD Medications and Treatments — Mon, 23 Jan 2006 05:00:00 +0100

This study emphasized the need for baseline and periodic monitoring of blood pressure and heart rate in adults receiving medications for ADHD. Blood pressure measurements over 140/90 might require a lowering or discontinuation of ADD medications, or the addition of a high blood pressure medication. Related Topics: Hypertension: Medications Related to Hypertension, ADHD Medications ChartTechnorati Tags: ADHD, hypertension, high blood pressure, ADHD medications (Source: ADHD Medications and Treatments)

Daytrana: Medication Patch for ADHD Update

ADHD Medications and Treatments — Fri, 20 Jan 2006 05:00:00 +0100

An FDA advisory panel has recommended approval of the transdermal methylphenidate patch (brand name Daytrana). It is recommended that the patch be applied in the morning and removed approximately nine hours later, or about two hours before bedtime. There are many children who have difficulty swallowing pills, and liquid preparations of methylphenidate are short-acting and are effective for only about 3 - 4 hours, so Daytrana offers these children a longer-acting preparation. When the patch was left on for 12 hours, there was a significant incidence of insomnia, but when the patch in left on for nine hours, efficacy and side effects are fairly comparable to Concerta. Improvements in symptoms of ADHD were found to occur within two hours of putting on the patch and persisted for approximately...

A Laboratory School Comparison of Mixed Amphetamine Salts Extended Release (Adderall XR(R)) and Atomoxetine (Strattera(R)) in School-Aged Children With Attention Deficit/Hyperactivity Disorder

Journal of Attention Disorders — Wed, 21 Dec 2005 07:00:00 +0100

Mixed amphetamine salts extended release (MAS XR; Adderall XR®) and atomoxetine (Strattera®) were compared in children 6 to 12 years old with attention deficit/hyperactivity disorder (ADHD) combined or hyperactive/impulsive type in a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study. Primary efficacy measure was the SKAMP (Swanson, Kotkin, Agler, M-Flynn, and Pelham) behavioral rating scale. Changes in mean SKAMP deportment scores from baseline were significantly greater for MAS XR (n = 102) than for atomoxetine (n = 101) overall (-0.56 and -0.13, respectively; p < .0001) and at each week (p < .001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of ...

Young adults with ADHD - ADDERALL XR significantly improves driving performance, study

ADHD News From Medical News Today — Sat, 12 Nov 2005 07:00:00 +0100

ADDERALL XR® (mixed salts of a single-entity amphetamine product) significantly improved driving performance, cognitive function and attention in young adults with attention-deficit/hyperactivity disorder (ADHD) in a controlled driving simulator study conducted by the Washington Neuropsychological Institute and presented today at the 18th Annual U.S. Psychiatric & Mental Health Congress in Las Vegas, NV. [click link for full article] (Source: ADHD News From Medical News Today)

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