MedWorm: Albuterol

ALBUTEROL SULFATEsolution [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 02 Feb 2012 05:00:00 +0100

Updated Date: Feb 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 30 Jan 2012 05:00:00 +0100

Updated Date: Jan 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 27 Jan 2012 05:00:00 +0100

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 25 Jan 2012 05:00:00 +0100

Updated Date: Jan 25, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 25 Jan 2012 05:00:00 +0100

Updated Date: Jan 25, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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VENTOLIN HFA (Albuterol Sulfate) Aerosol, Metered [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 24 Jan 2012 05:00:00 +0100

Updated Date: Jan 24, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effect of Polymorphism of the β2-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma

International Archives of Allergy and Immunology — Mon, 23 Jan 2012 23:00:00 +0100

Int Arch Allergy Immunol 2001;124:183–186 (DOI:10.1159/000053705) (Source: International Archives of Allergy and Immunology)

An In-Vitro Evaluation of Aerosol Delivery Through Tracheostomy and Endotracheal Tubes Using Different Interfaces.

Respiratory Care — Mon, 23 Jan 2012 05:00:00 +0100

CONCLUSION: In this adult model of spontaneous ventilation, aerosol therapy through ETT is less efficient than TT, while the ambu bag was more efficient than T-piece or tracheostomy collar. PMID: 22273459 [PubMed - as supplied by publisher] (Source: Respiratory Care)

A Large Subgroup of Mild-to-Moderate Asthma is Persistently Non-Eosinophilic.

American Journal of Respiratory and Critical Care Medicine — Fri, 20 Jan 2012 05:00:00 +0100

CONCLUSIONS: Approximately half of patients with mild-to-moderate asthma have persistently non-eosinophilic disease, a disease phenotype that responds poorly to currently available anti-inflammatory therapy. PMID: 22268133 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Incidence of laryngospasm and bronchospasm in pediatric adenotonsillectomy

The Laryngoscope — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions:The rates of laryngospasm (1.6%) and bronchospasm (1.8%) are significantly lower than reported in the literature, reflecting refinements in modern anesthesia/surgical technique. Knowledge of at‐risk patients can facilitate planning to potentially reduce the incidence of perioperative airway complications during adenotonsillectomy. (Source: The Laryngoscope)

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Spirometry with bronchodilator test: effect that the use of large-volume spacers with antistatic treatment has on test response

Jornal Brasileiro de Pneumologia — Sat, 14 Jan 2012 21:08:57 +0100

CONCLUSIONS: According to the results of this study, the use of large-volume spacers does not significantly modify bronchodilator test results. (Source: Jornal Brasileiro de Pneumologia)

ALBUTEROL (Albuterol Sulfate) Tablet [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 12 Jan 2012 05:00:00 +0100

Updated Date: Jan 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 11 Jan 2012 05:00:00 +0100

Updated Date: Jan 11, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 Jan 2012 05:00:00 +0100

Updated Date: Jan 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence of Polypharmacy Exposure Among Hospitalized Children in the United States [Article]

Archives of Pediatrics — Mon, 02 Jan 2012 05:00:00 +0100

Conclusion A large fraction of hospitalized pediatric patients are exposed to substantial polypharmacy, especially patients with rare conditions. (Source: Archives of Pediatrics)

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β2-Adrenergic Receptor Agonists Modulate Human Airway Smooth Muscle Cell Migration via Vasodilator-Stimulated Phosphoprotein.

American Journal of Respiratory Cell and Molecular Biology — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri RA Abstract Severe asthma manifests as airway remodeling and irreversible airway obstruction, in part because of the proliferation and migration of human airway smooth muscle (HASM) cells. We previously reported that cyclic adenosine monophosphate-mobilizing agents, including β(2)-adrenergic receptor (β(2)AR) agonists, which are mainstay of asthma therapy, and prostaglandin E2 (PGE2), inhibit the migration of HASM cells, although the mechanism for this migration remains unknown. Vasodilator-stimulated phosphoprotein (VASP), an anticapping protein, modulates the formation of actin stress fibers during cell motility, and is negatively regulated by protein kinase A (PKA)-specific inhibitory phosphorylati...

Late-night Wheezer: Providers respond to pediatric asthma patient

JEMS: Journal of Emergency Medical Services — Sun, 01 Jan 2012 05:00:00 +0100

On a warm spring night, MedicWest ambulance and the Clark County (Nev.) Fire Department are dispatched to a difficulty breathing call in a low-income neighborhood east of the Las Vegas strip. On arrival, they encounter an 8-year-old girl with difficulty breathing. The mother reports that the child has a history of asthma but has been out of her albuterol inhaler for approximately two weeks. (Source: JEMS: Journal of Emergency Medical Services)

Albuterol Isomers Modulate Platelet-Activating Factor Synthesis and Receptor Signaling in Human Bronchial Smooth Muscle Cells

International Archives of Allergy and Immunology — Tue, 27 Dec 2011 23:00:00 +0100

Int Arch Allergy Immunol 2012;158:18–26 (DOI:10.1159/000330029) (Source: International Archives of Allergy and Immunology)

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Nephron Pharmaceuticals Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 27 Dec 2011 05:00:00 +0100

Updated Date: Dec 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Short answer question case series: a fatal case of swelling

Emergency Medicine Journal — Tue, 20 Dec 2011 05:00:00 +0100

Case vignette A 40-year-old woman presents at 08:40 with her fifth episode of lip and tongue swelling. She is immediately given intravenous diphenhydramine, methylprednisolone and famotidine. Her oxygen saturation is 100% with stable vital signs. At 10:30, she develops neck swelling, dyspnoea and dysphagia, but speaks with full sentences. An anaesthesiologist is called for early intubation, an otolaryngologist is called for possible tracheostomy, and the patient is given subcutaneous epinephrine and nebulised albuterol. However, her respiratory rate increases to 30 breaths/min as pulse oximetry drops to 89%. Additional epinephrine is administered, but she continues to decompensate. The anaesthesiologist is unable to intubate the patient. The otolaryngologist is unable to locate the tr...

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Albuterol Increases Death Risk in ARDS, Study Finds (CME/CE)

MedPage Today Pediatrics — Sun, 11 Dec 2011 22:30:00 +0100

(MedPage Today) -- An infusion of albuterol early after the onset of acute respiratory distress syndrome (ARDS) increases the risk of dying, the halted BALTI-2 trial showed. (Source: MedPage Today Pediatrics)

Albuterol Modulates its own Transepithelial Flux via Changes in Paracellular Permeability.

Am J Respir Cell Mol... — Thu, 08 Dec 2011 05:00:00 +0100

Conclusions: Albuterol mainly crosses the epithelium via the paracellular pathway, but has the ability to modulate its own permeability though changes in the leakiness of tight junctions, which is modulated through signaling of the β2 adrenergic receptor. PMID: 22162907 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)

ALBUTEROL SULFATEsolution [Ritedose Pharmaceuticals, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 07 Dec 2011 05:00:00 +0100

Updated Date: Dec 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Helium-Oxygen Therapy for Infants With Bronchiolitis: A Randomized Controlled Trial [Article]

Archives of Pediatrics — Mon, 05 Dec 2011 05:00:00 +0100

Conclusion Nebulized racemic epinephrine delivered by helium-oxygen followed by helium-oxygen inhalation therapy delivered by HFNC was associated with a greater degree of clinical improvement compared with that delivered by oxygen among infants with bronchiolitis. Trial Registration clinicaltrials.gov Identifier: NCT00116584 (Source: Archives of Pediatrics)

A multivalent approach to the discovery of long-acting β(2)-adrenoceptor agonists for the treatment of asthma and COPD.

Bioorganic and Medicinal Chemistry Letters — Fri, 25 Nov 2011 05:00:00 +0100

Authors: Jacobsen JR, Choi SK, Combs J, Fournier EJ, Klein U, Pfeiffer JW, Thomas GR, Yu C, Moran EJ Abstract A multivalent approach was applied to the design of long-acting inhaled β(2)-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β(2)-adrenoceptor agonist albuterol were prepared, varying the nature and length of the linker between the basic nitrogens. None of the C(2)-symmetric dimers demonstrated increased potency, however dimer 5j, derived from 4-phenethylamine, was found to have increased binding potency in vitro relative to the parent monomer. Optimization of this structure led to the identification of 22 (milveterol) which demonstrates high potency in vitro and long duration of action in a guinea pig model of bronchoprotection. ...

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In children and adolescents with mild persistent asthma, daily beclomethasone reduces treatment failure compared with rescue beclomethasone plus albuterol

Evidence-Based Medicine — Sun, 20 Nov 2011 05:00:00 +0100

Context Many studies have shown that regular use of inhaled corticosteroids improves asthma control in children with asthma. However, intermittent therapy with inhaled corticosteroids is common practice in the community1 as many physicians and families are reluctant to administer inhaled corticosteroids long term. Several previous studies have examined this approach and have generally not found it to be convincingly effective. The investigators wished to evaluate the efficacy of this approach in children potentially ready to be ‘weaned off’ inhaled corticosteroids. Their findings add to the body of literature evaluating the efficacy of intermittent therapy with inhaled corticosteroids in children with mild, persistent asthma. Methods This was a large, multicentre, randomised, d...

PROVENTIL HFA (Albuterol Sulfate) Aerosol, Metered [Rebel Distributors Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Nov 2011 05:00:00 +0100

Updated Date: Nov 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

PROAIRHFA (Albuterol Sulfate) Aerosol, Metered [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Nov 2011 05:00:00 +0100

Updated Date: Nov 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Teva Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Relationship between polymorphisms in the 5′ leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China

Respirology — Tue, 01 Nov 2011 04:00:00 +0100

Conclusions: The Arg19/Cys19 genotype was an independent risk factor for lower FEV1% and FEV1/FVC. Asthmatic patients with the Arg19/Arg19 genotype showed decreased responsiveness to albuterol. Furthermore, the Arg19/Arg16/Gln27 haplotype may contribute to increased susceptibility to asthma in the Chinese population. (Source: Respirology)

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Focused Assessment of Patients with Asthma in the Emergency Department: Kanis K, Lovell J, Bowan M, Titus MO. Clin Pediatr 2011;50:529–34.

The Journal of Emergency Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Asthma accounts for approximately 20 million visits to emergency departments (EDs) across the country every year. Clinical asthma severity (CAS) scores have been developed in an attempt to improve and standardize asthma care during acute exacerbations. In this retrospective chart review, Kanis et al. attempted to determine whether the adoption of a CAS score for pediatric patients within their large urban ED improved identification of patients with severe asthma and increased the aggressiveness of treatment received. When comparing all asthma patients seen within their ED in the 18 months preceding the implementation of a CAS score to the first 18 months after the implementation of the CAS score, there were little differences in the percentage of patients admitted to the hospital (pre-CAS ...

Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD

Respiratory Medicine — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: The addition of FSC to subjects with COPD treated with TIO significantly improves lung function without increasing the risk of adverse events. NCT00784550. (Source: Respiratory Medicine)

Flash pulmonary oedema during anidulafungin administration

Journal of Clinical Pharmacy and Therapeutics — Thu, 20 Oct 2011 04:00:00 +0100

Conclusion: This is the first report of pulmonary oedema attributable to an echinocandin antifungal agent. While such infusion‐related adverse events including pulmonary oedema appear uncommon, it is important for clinicians to be aware of this possibility and maintain the drug’s infusion rate to <1·1 mg/min and monitor for signs and symptoms of pulmonary oedema. (Source: Journal of Clinical Pharmacy and Therapeutics)

Albuterol side effects: What's normal?

MayoClinic.com Full Feed — Tue, 18 Oct 2011 05:00:00 +0100

Albuterol side effects — Avoid bothersome reactions to quick-relief asthma medication. (Source: MayoClinic.com Full Feed)

Maternal bronchodilator use and the risk of orofacial clefts

Human Reproduction — Tue, 18 Oct 2011 04:00:00 +0100

CONCLUSIONS We observed a statistically significant association between maternal bronchodilator use during the periconceptional period and the risk of CLO after controlling for other risk factors. It is unclear whether the increased odds ratios observed in this study are due to the bronchodilators, the severity of asthma, or both, or to chance alone. Further studies to disentangle the role of asthma or asthma medications would help clarify these findings. (Source: Human Reproduction)

Safety and Efficacy of Two Potassium Cocktail Formulations for Treatment of Neonatal Hyperkalemia (November).

The Annals of Pharmacotherapy — Tue, 18 Oct 2011 04:00:00 +0100

CONCLUSIONS:An intravenous infusion including a dextrose:insulin ratio of 3.3:1, compared with a higher ratio, results in less hyperglycemia and appears to be as effective in decreasing potassium concentrations in newborns. PMID: 22009997 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Bronchodilator responsiveness in wheezy infants and toddlers is not associated with asthma risk factors

Pediatric Pulmonology — Mon, 17 Oct 2011 04:00:00 +0100

ConclusionsApproximately one quarter of infants/toddlers with recurrent wheezing exhibited BDR at their clinical baseline. However, BDR in wheezy infants/toddlers was not associated with established clinical asthma risk factors. Pediatr Pulmonol. © 2011 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)

Combivent Respimat (Ipratropium Bromide and Albuterol) - updated on RxList

RxList - New and Updated Drug Monographs — Thu, 13 Oct 2011 07:00:00 +0100

Combivent Respimat (Ipratropium Bromide and Albuterol) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

FDA Okays CFC-Free Spray to Treat COPD

MedPage Today Allergy — Tue, 11 Oct 2011 22:43:00 +0100

WASHINGTON (MedPage Today) -- The FDA has approved a combination of ipratropium bromide and albuterol sulfate (Combivent Respimat) inhalation spray for treatment of chronic obstructive pulmonary disease. (Source: MedPage Today Allergy)

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FDA Approves Combivent Respimat (ipratropium bromide and albuterol) Inhalation Spray for the Treatment of Patients with Chronic Obstructive Pulmonary Disease

Drugs.com - New Drug Approvals — Mon, 10 Oct 2011 11:10:32 +0100

RIDGEFIELD, Conn., Oct. 7, 2011 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Combivent Respimat, a new, propellant-free inhaler product that uses a... (Source: Drugs.com - New Drug Approvals)

FDA approves Combivent Respimat Inhalation Spray for patients with COPD

Drug Topics - Top News — Mon, 10 Oct 2011 04:00:00 +0100

FDA has approved ipratropium bromide and albuterol (Combivent Respimat Inhalation Spray, Boehringer Ingelheim) for patients using a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator. (Source: Drug Topics - Top News)

FDA Approves Combivent® Respimat® (ipratropium Bromide And Albuterol) Inhalation Spray For The Treatment Of Patients With COPD

Health News from Medical News Today — Sat, 08 Oct 2011 07:00:00 +0100

Boehringer Ingelheim Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved COMBIVENT RESPIMAT, a new, propellant-free inhaler product that uses a slow-moving mist to deliver the same active ingredients of COMBIVENT Inhalation Aerosol in a metered dose inhaler (COMBIVENT MDI). COMBIVENT RESPIMAT will be available for patients in mid-2012... (Source: Health News from Medical News Today)

FDA Approves Inhalation Spray for COPDFDA Approves Inhalation Spray for COPD

Medscape Today Headlines — Fri, 07 Oct 2011 22:57:29 +0100

An ipratropium bromide and albuterol sulfate inhalation spray will replace an aerosol version that is being phased out. Medscape Medical News (Source: Medscape Today Headlines)

ALBUTEROL SULFATEsyrup [Dispensing Solutions, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 04 Oct 2011 05:00:00 +0100

Updated Date: Oct 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Subcutaneous immunotherapy

Journal of Allergy and Clinical Immunology — Sat, 01 Oct 2011 04:00:00 +0100

A 26-year-old woman presents to an allergist for evaluation of symptoms consistent with allergic rhinitis and asthma present throughout the year but worse in the late spring. Her symptoms have been reasonably well controlled on medication consisting of nasal steroids, inhaled steroids, and albuterol on most days, with the addition of anti-inflammatory eye drops during her seasonal flare. She wonders whether there is something that can make her less dependent on “all of this medicine.” Further questioning reveals that she lives in an older home, which is damp, especially in the basement, and she notes increased symptoms on going into the basement. She also has had a cat for the last 3 years, which sleeps on her bed. She believes her symptoms have become generally worse since acquiring ...

Effects of Nebulized Bronchodilator Therapy on Heart Rate and Arrhythmias in Critically Ill Adult Patients.

Chest — Thu, 29 Sep 2011 04:00:00 +0100

CONCLUSIONS:In critically ill adult patients, nebulized albuterol and ipratropium does not cause significant tachycardia or tachyarrhythmias. Substitution of levalbuterol for albuterol to avoid tachycardia and tachyarrhythmias is unwarranted. PMID: 21960699 [PubMed - as supplied by publisher] (Source: Chest)

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ALBUTEROL SULFATEsolution [Nephron Pharmaceuticals Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 28 Sep 2011 05:00:00 +0100

Updated Date: Sep 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gasping for common sense

Health Facts and Fears — Fri, 23 Sep 2011 04:00:00 +0100

If you’re someone who relies on an over-the-counter inhaler to cope with asthma, you should be sure that you have a doctor’s prescription for an albuterol inhaler by the end of this year. (Source: Health Facts and Fears)

Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols.

European Journal of Pharmaceutical Sciences — Wed, 21 Sep 2011 04:00:00 +0100

Authors: El-Gendy N, Pornputtapitak W, Berkland C Abstract Particle engineering strategies remain at the forefront of aerosol research for localized treatment of lung diseases and represent an alternative for systemic drug therapy. With the hastily growing popularity and complexity of inhalation therapy, there is a rising demand for tailor-made inhalable drug particles capable of affording the most proficient delivery to the lungs and the most advantageous therapeutic outcomes. To address this formulation demand, nanoparticle agglomeration was used to develop aerosols of the asthma therapeutics, fluticasone or albuterol. In addition, a combination aerosol was formed by drying agglomerates of fluticasone nanoparticles in the presence of albuterol in solution. Powders of the single d...

Beneficial effects of albuterol in congenital endplate acetylcholinesterase deficiency and Dok‐7 myasthenia

Muscle and Nerve — Mon, 19 Sep 2011 04:00:00 +0100

Discussion:Our observations should spur controlled, prospective clinical trials of albuterol in these as well as other CMS. (Source: Muscle and Nerve)

ALBUTEROL SULFATEsolution [Rebel Distributors Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 14 Sep 2011 05:00:00 +0100

Updated Date: Sep 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Prevalence of Polypharmacy Exposure Among Hospitalized Children in the United States [Article]

Archives of Pediatrics — Sun, 04 Sep 2011 23:00:00 +0100

Conclusion A large fraction of hospitalized pediatric patients are exposed to substantial polypharmacy, especially patients with rare conditions. (Source: Archives of Pediatrics)

Impact of Race on Asthma Treatment Failures in the Asthma Clinical Research Network.

American Journal of Respiratory and Critical Care Medicine — Thu, 01 Sep 2011 04:00:00 +0100

CONCLUSION: Despite having fewer asthma symptoms and less rescue beta-agonist use, African-Americans with asthma have more treatment failures compared with Caucasians, especially when taking long-acting beta-agonists. PMID: 21885625 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

The Response of Children with Asthma to Ambient Particulate is Modified by Tobacco Smoke Exposure.

American Journal of Respiratory and Critical Care Medicine — Wed, 24 Aug 2011 23:00:00 +0100

CONCLUSIONS: This study suggests that ETS modifies the acute effects of low-level ambient PM2.5 exposure on childhood asthma. This negative interaction, the smaller effect of particulate matter exposure in children exposed to higher ETS, may be related to a nonlinear dose-response relationship between asthma mediators and particulate exposures. PMID: 21868505 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients

Infectious Diseases in Obstetrics and Gynecology — Wed, 24 Aug 2011 19:34:03 +0100

Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to short-acting b2-agonists. Bronchodilator responsiveness was assessed in 133 asthmatic children by % change in baseline forced expiratory volume in one second (FEV1) after administration of albuterol. The analyses were performed in patients with airway obstruction (FEV1/FVC ratio below 90%, n=93). FEV1 % change adjusted for baseline FEV1 values was significantly different between genotypes of rs1544791 G/A polymorphism (P=0.006) and −1345 C/T (rs1504982) promoter variation (P=...

ALBUTEROL SULFATEsolution [Sandoz Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Aug 2011 05:00:00 +0100

Updated Date: Aug 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity

Journal of Allergy and Clinical Immunology — Mon, 22 Aug 2011 04:00:00 +0100

Conclusion: Nocturnal symptoms requiring albuterol in children with mild-to-moderate persistent asthma receiving controller therapy occurred predominantly outside of exacerbation periods. Despite being poor predictors of exacerbations, they were associated with increases in albuterol use, school absences, and doctor contacts the day after nocturnal symptom occurrences. (Source: Journal of Allergy and Clinical Immunology)

Bronchospasm and cardiac arrest during cesarean section

International Journal of Obstetric Anesthesia — Tue, 16 Aug 2011 04:00:00 +0100

A 23-year-old woman at 38weeks of gestation required an urgent cesarean section because of arrest of dilatation and non-reassuring fetal heart tracings. She had a history of poorly-controlled asthma and had been using an albuterol inhaler up to four times daily, but denied any recent asthma attack. Preoperative physical examination was unremarkable. In the operating suite, crystalloid preloading was started and spinal anesthesia was administered at the L3–4 interspace with bupivacaine 12mg and morphine 200μg. The patient was positioned supine with 15° left lateral tilt. Standard monitors were applied, non-invasive blood pressure (BP) readings were taken at 1-min intervals and supplemental oxygen was administered via nasal cannulae. The BP fell to 75/39mmHg and after intravenous phenyle...

Platelet nitric oxide signalling in heart failure: role of oxidative stress

Cardiovascular Research — Mon, 15 Aug 2011 23:00:00 +0100

Conclusion In heart failure, despite activation of NOS, platelets produce less bioactive NO, probably as a result of NO scavenging due to increased O2– production. This functional defect in the platelet l-arginine/NO/guanylyl cyclase pathway could contribute to the platelet activation observed in heart failure. (Source: Cardiovascular Research)

A young boy with bullae

Journal of the American Academy of Dermatology — Fri, 12 Aug 2011 16:59:53 +0100

A 6-year-old male presents with a 4-month history of recurrent, painful bullae involving the abdomen, groin, and occasionally the axillae and proximal limbs. Previous treatment with a 10-day course of oral cephalexin was not helpful. His parents deny that he has had any recent illnesses. There is no recent history of vaccination or new drug exposure. The boy is otherwise in good health, with the exception of mild asthma controlled with inhaled albuterol. The physical examination reveals numerous painful serous to hemorrhagic tense bullae and hemorrhagic erosions (). The oral mucosa and conjunctiva are normal. (Source: Journal of the American Academy of Dermatology)

Lucina

Archives of Disease in Childhood — Wed, 10 Aug 2011 23:00:00 +0100

Guidelines suggest daily use of inhaled steroid for persistent asthma with ‘step-down’ of treatment after control has been achieved. The exact nature of step-down treatment is, however open to debate. Researchers in the USA (Lancet 2011;377:650–7, see also Comment, ibid:614–16) have suggested that treatment with an inhaled steroid (beclomethasone) and a selective short-acting β2 agonist (salbutamol (albuterol)) only during exacerbations (rescue treatment) could be an appropriate choice. A total of 288 patients aged 5–18 years with mild persistent asthma responsive to twice daily inhaled beclomethasone dipropionate were randomly allocated to one of four treatment groups for 44 weeks. With a 2.2 factorial design the options were twice daily beclomethasone o...

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Relationship between polymorphisms in the 5’ leader cistron, positions 16 and 27 of the adrenergic beta‐2 receptor gene and asthma in a Han population from southwest China

Respirology — Sun, 31 Jul 2011 23:00:00 +0100

{beta}2AR Agonists Modulate Human Airway Smooth Muscle Cell Migration Via VASP.

Am J Respir Cell Mol... — Wed, 27 Jul 2011 23:00:00 +0100

Authors: Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri Jr RA Severe asthma manifests by airway remodeling and by irreversible airway obstruction in part due to human airway smooth muscle (HASM) cell proliferation and migration. Our previous studies report that cyclic AMP-mobilizing agents, including β2-adrenergic receptor (β2AR) agonists, a mainstay of asthma therapy, and prostaglandin E2 (PGE2), inhibit HASM cell migration although the mechanism remains unknown. Vasodilator-stimulated phosphoprotein (VASP), an anti-capping protein, modulates actin stress fiber formation during cell motility and is negatively regulated by protein kinase A (PKA)-specific inhibitory phosphorylation at Ser157. Here, we show that treatment with β2AR agonists and PGE2 induces PKA...

Asthma Placebo "As Effective As Active Drug" Study Unveils

Health News from Medical News Today — Fri, 15 Jul 2011 09:00:00 +0100

Asthma and many ailments can be partially just in your head research released this week claims. A new study finds that the power of the placebo effect versus albuterol inhalers left asthma patients thinking that real and fake drugs were doing the same level of good. The results even convinced patients they were breathing much better even if they hadn't taken a real drug and hadn't actually improved much... (Source: Health News from Medical News Today)

Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness

Respiratory Research — Thu, 14 Jul 2011 23:00:00 +0100

Conclusions: : These findings suggest that baseline Rmin, a measurement that is easier to perform than spirometry, performs as well as or better than standard spirometric indices in distinguishing subjects with airway hyperresponsiveness from those without hyperresponsive airways. The relationship of baseline Rmin to asthma and airway hyperresponsiveness likely reflects a causal relation between conditions that stiffen airway walls and hyperresponsiveness. In conjunction with symptom history, Rmin could provide a clinically useful tool for assessing asthma and monitoring response to treatment. (Source: Respiratory Research)

Placebo Vs Albuterol Both Have Asthma Patients Feeling Fine

Health News from Medical News Today — Thu, 14 Jul 2011 16:00:00 +0100

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Placebo As Good As Asthma Drug, Say Patients

Health News from Medical News Today — Thu, 14 Jul 2011 00:00:00 +0100

Who is right when patients say they get the same relief from placebos for their asthma symptoms as their prescription drug, while clinical tests find that only the medication has any significant effect? These surprising findings were reported by Harvard University researchers in the latest issue of NEJM (New England Journal of Medicine). Symptoms of wheezing and coughing, according to participating stable asthma patients, improved with placebo inhalers (inhalers with dummy drugs in them) and fake acupuncture, to the same extent as with an albuterol inhaler, the patients reported... (Source: Health News from Medical News Today)

Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma

New England Journal of Medicine — Wed, 13 Jul 2011 21:00:05 +0100

New England Journal of Medicine, Volume 365, Issue 2, Page 119-126, July 2011. (Source: New England Journal of Medicine)

Effect of IL‐1β and TNF‐αvs IL‐13 on bronchial hyperresponsiveness, β2‐adrenergic responses and cellularity of bronchial alveolar lavage fluid

Autonomic and Autacoid Pharmacology — Fri, 01 Jul 2011 04:00:00 +0100

In this study, we have investigated the effect of these cytokines in naïve mice and those sensitized to ovalbumin (OVA) on bronchoconstrictions to methacholine (MCh) and the functional antagonism induced by β2‐adrenoceptor agonism.2 Naïve or OVA‐sensitized mice were treated for 3 days with IL‐1β (250 U), TNF‐α (150 ng), IL‐13 (5 μg) or combinations of IL‐1β with TNF‐α or IL‐1β with IL‐13. MCh‐induced bronchoconstriction and its sensitivity to albuterol, a β2‐adrenoceptor agonist, was assessed 24 h after the last cytokine administration.3 In naïve mice, responsiveness to MCh was significantly increased by the combination of IL‐1β and TNF‐α, IL‐13 alone or in combination with IL‐1β, but not by treatment with IL‐1β or TNF‐α alone. Si...

Nebulized Budesonide Added to Standard Pediatric Emergency Department Treatment of Acute Asthma: A Randomized, Double‐blind Trial

Academic Emergency Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Conclusions: For children 2 to 18 years of age treated in the ED for acute asthma, a single 2‐mg dose of budesonide added to standard therapy did not improve asthma severity scores or other short‐term ED‐based outcomes. (Source: Academic Emergency Medicine)

Beneficial effect of albuterol in congenital myasthenic syndrome with epsilon‐subunit mutations

Muscle and Nerve — Wed, 29 Jun 2011 23:00:00 +0100

We report 2 patients with CMS due to mutations in the AChR epsilon subunit. The first patient carries two heterozygous frameshift mutations, ε127ins5 and ε1293insG. The second patient is homozygous for the εC142Y mutation that curtails AChR expression to 22% of wild‐type in HEK cells. Treatment with pyridostigmine and 3,4‐diaminopyridine had a limited beneficial effect in the first patient, and the second patient became wheelchair‐bound during therapy. The additional use of albuterol produced dramatic improvement in strength and in activities of daily living in both patients. The efficacy and safety of albuterol in patients who harbor identified low‐expressor or null mutations in the epsilon or other subunits of AChR merits a well‐designed clinical trial. Muscle Nerve, 2011 (S...

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ALBUTEROL SULFATEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 13 Jun 2011 05:00:00 +0100

Updated Date: Jun 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATEsolution [Qualitest Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 08 Jun 2011 05:00:00 +0100

Updated Date: Jun 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Albuterol no help in acute lung injury

Modern Medicine — Tue, 07 Jun 2011 23:00:00 +0100

NEW YORK (Reuters Health) - Treatment with the aerosolized beta-2 adrenergic agonist albuterol (salbutamol) doesn't improve clinical outcomes in critically ill patients with acute lung injury, researchers report. (Source: Modern Medicine)

ALBUTEROL SULFATEsyrup [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 06 Jun 2011 05:00:00 +0100

Updated Date: Jun 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

News Beyond Our Pages

Journal of Allergy and Clinical Immunology — Tue, 31 May 2011 23:00:00 +0100

Fernando D. Martinez, from the University of Arizona, and coauthors (Lancet 2011;377:650-7) presented results from the National Heart, Lung, and Blood Institute's consortium study TReating Children to Prevent EXacerbations of Asthma (TREXA), which was designed to determine whether beclomethasone and albuterol were effective rescue treatments with and without daily inhaled corticosteroids (ICSs) and whether discontinuation of daily ICSs in children with well-controlled, mild, persistent asthma would result in increased exacerbation risk. The authors reported that beclomethasone plus albuterol rescue was effective in decreasing exacerbation risk, although to a lesser degree than twice-daily beclomethasone plus albuterol. Unexpectedly, the authors found that the exacerbation frequency of becl...

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Visual compatibility of common nebulizer medications with 7% sodium chloride solution.

American Journal of Health-System Pharmacy : AJHP — Mon, 30 May 2011 00:00:21 +0100

Conclusion Eleven medications used in nebulizers for the treatment of CF were visually compatible with 7% sodium chloride solution. PMID: 21593232 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

A Case of "Refractory Asthma"

Consultant Live — Wed, 25 May 2011 17:00:01 +0100

A 43-year-old African American woman presented to the emergency department with severe dyspnea, wheeze, and cough productive of white sputum. Three years earlier, she had been given a diagnosis of asthma based on symptoms of wheeze and cough; her treatment regimen included intermittent use of albuterol. (Source: Consultant Live)

ALBUTEROL (Albuterol Sulfate) Tablet [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 23 May 2011 05:00:00 +0100

Updated Date: May 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

[Correspondence] Treatment of mild persistent asthma in children

LANCET — Fri, 20 May 2011 17:45:18 +0100

In their randomised controlled study of children with mild persistent asthma, Fernando Martinez and colleagues show that regular inhaled steroids plus use of combined inhaled steroids plus salbutamol for rescue use is best at reducing and preventing excacerbations (measured by treatment failure). They conclude that “the most effective treatment to prevent exacerbations is daily inhaled corticosteroids”. However they, and in his accompanying Comment, William Checkley, imply that inhaled corticosteroids as rescue medication with albuterol/salbutamol might be useful for treating these children. (Source: LANCET)

ALBUTEROL SULFATEtablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 19 May 2011 05:00:00 +0100

Updated Date: May 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ALBUTEROL SULFATEtablet [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 18 May 2011 05:00:00 +0100

Updated Date: May 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALBUTEROL SULFATE (Albuterol Sulfate) Solution [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 13 May 2011 05:00:00 +0100

Updated Date: May 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Randomized, Placebo-Controlled Clinical Trial of an Aerosolized Beta-2 Agonist for Treatment of Acute Lung Injury.

American Journal of Respiratory and Critical Care Medicine — Tue, 10 May 2011 23:00:00 +0100

CONCLUSIONS: These results suggest that aerosolized albuterol does not improve clinical outcomes in ALI patients. Routine use of beta-2 agonist therapy in mechanically ventilated ALI patients cannot be recommended. Clinical trials information available at www.clinicaltrials.gov, trial registry code NCT00434993. PMID: 21562125 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)

Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial.

Annals of Internal Medicine — Mon, 02 May 2011 23:00:00 +0100

Conclusion: In this study, omalizumab provided additional clinical benefit for patients with severe allergic asthma that is inadequately controlled with high-dose ICS and LABA therapy. Primary Funding Source: Genentech and Novartis Pharmaceuticals. PMID: 21536936 [PubMed - in process] (Source: Annals of Internal Medicine)

Bronchodilator responsiveness and onset of effect with budesonide/formoterol pMDI in COPD

Respiratory Medicine — Sun, 01 May 2011 23:00:00 +0100

Conclusions: Most patients with moderate to very severe COPD exhibit ATS-defined bronchodilator reversibility based on flow and lung volume measures after budesonide/formoterol pMDI or formoterol treatment. Budesonide/formoterol pMDI also has a rapid (within 5min) onset of bronchodilation that is maintained over time compared with formoterol alone. (Source: Respiratory Medicine)

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Cost-effectiveness of Metered-Dose Inhalers for Asthma Exacerbations in the Pediatric Emergency Department

PEDIATRICS — Sat, 30 Apr 2011 23:00:00 +0100

CONCLUSIONS: Use of MDIs with spacers in place of wet nebulizers to deliver albuterol to treat children with mild-to-moderate asthma exacerbations in the ED could yield significant cost savings for hospitals and, by extension, to both the health care system and families of children with asthma. (Source: PEDIATRICS)

Duoneb (Ipratropium Bromide and Albuterol Sulfate) - updated on RxList

RxList - New and Updated Drug Monographs — Fri, 22 Apr 2011 07:00:00 +0100

Duoneb (Ipratropium Bromide and Albuterol Sulfate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

AccuNeb (Albuterol Sulfate Inhalation Solution) - updated on RxList

RxList - New and Updated Drug Monographs — Thu, 21 Apr 2011 07:00:00 +0100

AccuNeb (Albuterol Sulfate Inhalation Solution) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 13 Apr 2011 05:00:00 +0100

Updated Date: Apr 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

VENTOLIN (Albuterol Sulfate) Aerosol, Metered [GlaxoSmithKline LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 13 Apr 2011 05:00:00 +0100

Updated Date: Apr 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ACCUNEB (Albuterol Sulfate) Solution [Dey Pharma, LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 05 Apr 2011 05:00:00 +0100

Updated Date: Apr 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DUONEB (Ipratropium Bromide And Albuterol Sulfate) Solution [Dey Pharma LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 04 Apr 2011 05:00:00 +0100

Updated Date: Apr 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Should mild persistent asthma be treated with rescue albuterol alone?

Modern Medicine Contemporary Pediatrics — Thu, 31 Mar 2011 23:00:00 +0100

To assess whether a combination of inhaled beclomethasone plus albuterol could be used as a rescue medication regimen to reduce the frequency of exacerbations, whether the patient also used daily beclomethasone, investigators conducted a trial. (Source: Modern Medicine Contemporary Pediatrics)

Naturally influential

Thrive, Children's Hospital Boston — Fri, 25 Mar 2011 14:02:58 +0100

Written by Aaron Bernstein, MD, MPH, a pediatrician at Children’s Hospital Boston and faculty member at Harvard Medical School’s Center for Health and the Global Environment. In the Middle Ages, people concocted mixtures of wormwood, mint and balm to treat stomach problems and applied rubs made of rose and lavender to alleviate chronic migraines. Considering how far medicine has come since, many people assume that modern science is the driving force behind today’s powerful drugs. It may surprise them to learn that he world around us is still the source of most of our modern medicines. For the past 30 years, only 1/3 of the drugs approved by U.S. Food and Drug Administration were created in labs, based on human resourcefulness alone. The remaining 2/3 were given to us, more or less, ...

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ALBUTEROL SULFATEsolution [Dey Pharma L.P.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Mar 2011 05:00:00 +0100

Updated Date: Mar 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula

Pediatric Pulmonology — Thu, 24 Mar 2011 00:00:00 +0100

AbstractDrug administration via high flow nasal cannula (HFNC) has been described in pediatrics but the amount of albuterol delivery with an HFNC is not known. The purpose of this study is to quantify aerosol delivery with heliox and oxygen (O2) in a model of pediatric ventilation. A vibrating mesh nebulizer (Aeroneb Solo, Aerogen) was placed on the inspiratory inlet of a heated humidifier and heated wire circuit attached to a pediatric nasal cannula (Optiflow, Fisher & Paykel). Breathing parameters were tidal volume (Vt) 100 ml, respiratory rate (RR) 20/min, and I‐time of 1 sec. Albuterol sulfate (2.5 mg/3 ml) was administered through a pediatric HFNC with O2 (100%) and heliox (80/20% mixture). A total of 12 runs, using O2 and heliox were conducted at 3 and 6 L/min (n =�...

ALBUTEROL SULFATEsolution [Rebel Distributors Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Mar 2011 05:00:00 +0100

Updated Date: Mar 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of beta-receptor affinity in murine models of asthma

Respiratory Research — Mon, 07 Mar 2011 00:00:00 +0100

Conclusions: We conclude that long term inhalation treatment with either isomer of albuterol is capable of precipitating IAR and AHR in allergically inflamed airways but not in intrinsically hyperresponsive mice or immunologically naive mice. Because (S)-albuterol, which lacks affinity for the beta2-receptor, did not differ from (R)-albuterol, we speculate that isomer-independent properties of the albuterol molecule, other than beta2-agonism, are responsible for the effect on AHR. (Source: Respiratory Research)

COMBIVENT (Ipratropium Bromide And Albuterol Sulfate) Aerosol, Metered [Boehringer Ingelheim Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Mar 2011 05:00:00 +0100

Updated Date: Mar 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Long-term Safety and Efficacy of Indacaterol, a Novel Long-acting {beta}2-Agonist, in Subjects with COPD: a Randomized, Placebo-controlled Study.

Chest — Thu, 24 Feb 2011 00:00:00 +0100

CONCLUSIONS: During 1 year of treatment, indacaterol was well tolerated and provided significant and well-maintained bronchodilation that was accompanied by improved clinical outcomes. PMID: 21349928 [PubMed - as supplied by publisher] (Source: Chest)

ALBUTEROL SULFATEsyrup [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Feb 2011 05:00:00 +0100

Updated Date: Feb 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Azathioprine-Induced Fever in Sarcoidosis (March).

The Annals of Pharmacotherapy — Tue, 22 Feb 2011 00:00:00 +0100

CONCLUSIONS: The rapid resolution of fever after discontinuation of azathioprine suggests that it was the likely source of fever in this patient. If azathioprine is increasingly prescribed in patients with sarcoidosis, fever as an adverse reaction may become more common. PMID: 21343403 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

[Articles] Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial

LANCET — Fri, 18 Feb 2011 18:01:52 +0100

Children with mild persistent asthma should not be treated with rescue albuterol alone and the most effective treatment to prevent exacerbations is daily inhaled corticosteroids. Inhaled corticosteroids as rescue medication with albuterol might be an effective step-down strategy for children with well controlled, mild asthma because it is more effective at reducing exacerbations than is use of rescue albuterol alone. Use of daily inhaled corticosteroid treatment and related side-effects such as growth impairment can therefore be avoided. (Source: LANCET)

ACCUNEB (Albuterol Sulfate) Solution [Dey Pharma, LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Feb 2011 05:00:00 +0100

Updated Date: Feb 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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DUONEB (Ipratropium Bromide And Albuterol Sulfate) Solution [Dey Pharma LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Feb 2011 05:00:00 +0100

Updated Date: Feb 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The validity of using ICD-9 codes and pharmacy records to identify patients with chronic obstructive pulmonary disease

BMC Health Services Research — Wed, 16 Feb 2011 00:00:00 +0100

Conclusion: Commonly used definitions of COPD in observational studies misclassify the majority of patients as having COPD. Using multiple diagnostic codes in combination with pharmacy data improves the ability to accurately identify patients with COPD. (Source: BMC Health Services Research)

Combo Rescue Best in Asthma (CME/CE)

MedPage Today Pediatrics — Tue, 15 Feb 2011 19:31:40 +0100

(MedPage Today) -- Asthmatic children had fewer exacerbations and significantly fewer treatment failures with combination rescue therapy -- an inhaled corticosteroid and albuterol -- according to results of a randomized trial. (Source: MedPage Today Pediatrics)

Alternative Way to Treat Childhood Asthma?

WebMD Health — Tue, 15 Feb 2011 05:00:00 +0100

Using inhaled steroids as a rescue medicine along with albuterol may help some children with mild persistent asthma avoid daily inhaled steroid therapy and one of its potential side effects, namely growth restriction. (Source: WebMD Health)

Inhibitory effects of albuterol and fenoterol on RANTES and IP‐10 expression in bronchial epithelial cells

Pediatric Allergy and Immunology — Tue, 15 Feb 2011 00:00:00 +0100

To cite this article: Lam KP, Chu YT, Lee MS, Chen HN, Wang WL, Tok TS, Chin YY, Chen SC, Kuo CH, and Hung CH. Inhibitory Effects of Albuterol and Fenoterol on RANTES and IP‐10 Expression in Bronchial Epithelial Cells. Pediatric Allergy Immunology 2011.AbstractShort‐acting β2‐adrenoreceptor agonist (SABA) is the major asthma reliever as indicated in the GINA guidelines. Regulated on activation, normal T expressed and secreted (RANTES) is a chemokine that attracts eosinophils, mast cells, and basophils toward site of allergic inflammation. Interferon γ‐inducible protein (IP)‐10 is a Th1‐related chemokine that is also important in asthmatic inflammation and also involved in our immune defense against pathogens. Bronchial epithelial cells are first‐line barrier against invasiv...

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Corticosteroid Effective Asthma Rescue Addition

Modern Medicine — Tue, 15 Feb 2011 00:00:00 +0100

Inhaled corticosteroids as rescue medication with albuterol may be a useful step-down strategy for children with well-controlled, mild asthma as it is more effective at reducing exacerbations than is use of rescue albuterol alone in this population, according to a study published online Feb. 15 in The Lancet. (Source: Modern Medicine)

Randomized Controlled Trial Comparing a Breath Actuated Nebulizer to a Hospital's Standard Therapy to Treat Pediatric Asthma in the Emergency Department.

Respiratory Care — Fri, 11 Feb 2011 00:00:00 +0100

CONCLUSIONS: Although use of the BAN did not reduce time in the ED, it resulted in significant improvements in CAS, need for admission and a decrease in respiratory rate when compared to standard therapy (SVN/CONT). PMID: 21333060 [PubMed - as supplied by publisher] (Source: Respiratory Care)

An Unusual Cause of Chest Pain in a Child

The Journal of Pediatrics — Fri, 11 Feb 2011 00:00:00 +0100

A 12-year-old obese boy with a history of mild asthma managed with as-needed albuterol and episodic mild epistaxis presented with acute chest pain in the absence of known trauma. The patient had tachypnea and tachycardia with decreased breath sounds on the right, but had normoxia. Chest radiography revealed a large right pleural effusion (), and almost 2 L of bloody fluid was removed via thoracentesis and thoracostomy tube. Our initial differential for acute hemothorax included trauma, infection, bleeding diathesis, malignancy, and arterial venous malformation (AVM). Laboratory study results including platelet count and international normalized ratios were normal, and the examination result of the pleural fluid was negative for infection or the presence of malignant cells. Echocardiography...

Bronchodilation response to deep inspirations in asthma is dependent on airway distensibility and air trapping

Journal of Applied Physiology — Tue, 08 Feb 2011 00:00:00 +0100

We examined the relationship between DI-induced bronchodilation and airway distensibility in 15 asthmatic individuals with a wide range of baseline lung function [forced expired volume in 1 s (FEV1) = 60–99% predicted]. After abstaining from DIs for 20 min, subjects received a single-dose MCh challenge and then asked to perform DIs. The effectiveness of DIs was assessed by the ability of the subjects to improve FEV1. The same subjects were studied by two sets of high-resolution CT scans, one at functional residual capacity (FRC) and one at total lung capacity (TLC). In each subject, the areas of 21–41 airways (0.8–6.8 mm diameter at FRC) were matched and measured, and airway distensibility (increase in airway diameter from FRC to TLC) was calculated. The bronchodilatory a...

PROVENTIL HFA (Albuterol Sulfate) Aerosol, Metered [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 04 Feb 2011 05:00:00 +0100

Updated Date: Feb 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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The dilemma of albuterol dosing for acute asthma exacerbations in pediatric patients.

Chest — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Arnold DH, Moore PE, Abramo TJ, Hartert TV PMID: 21285065 [PubMed - in process] (Source: Chest)

Effects on Aerosol Performances of Mixing of Either Budesonide or Beclomethasone Dipropionate With Albuterol and Ipratropium Bromide.

Respiratory Care — Fri, 21 Jan 2011 00:00:00 +0100

Authors: Melani AS Mixing of nebulized drugs is common in real life, but its consequences on aerosol output and granulometry are poorly known. This in vitro study evaluated the effects on drug output and aerosol characteristics of mixing either beclomethasone dipropionate (BDP) or budesonide with albuterol and ipratropium bromide delivered by the reusable SideStream/AirClinic and VentStream-Pro/AirClinic nebulizer systems. Using the same fill volume, each studied drug was also nebulized and evaluated alone. Aerosol output was measured by gravimetrics. Drug output on a filter positioned into the inspiratory way and reservoir residual at dryness were collected and assayed by HPLC. Particle size distribution was evaluated by cascade impaction. Mixing tended to reduce drug output and to in...

ALBUTEROL SULFATEsyrup [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Jan 2011 05:00:00 +0100

Updated Date: Jan 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

COMBIVENT (Ipratropium Bromide And Albuterol Sulfate) Aerosol, Metered [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 11 Jan 2011 05:00:00 +0100

Updated Date: Jan 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial

Respiratory Research — Tue, 11 Jan 2011 00:00:00 +0100

Conclusions: A large proportion of COPD patients demonstrate significant acute BDR. BDR in these patients is variable over time and differs according to the criterion used. BDR status at baseline does not predict long-term response to tiotropium. Assessment of acute BDR should not be used as a decision-making tool when prescribing tiotropium to patients with COPD. (Source: Respiratory Research)

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Clearing the airways

Thrive, Children's Hospital Boston — Mon, 10 Jan 2011 16:48:21 +0100

Everyday Children’s Community Asthma Initiative helps patients like Marquis Lewis manage their asthma. For 17-year-old Marquis Lewis, it begins with a hacking, relentless cough. His heart pounds, his neck strains and his chest sinks in—all signals of his lungs’ desperate fight to capture even the smallest bit of air. “It gets real tight,” Marquis says, pointing to his chest. “It’s like I’m fighting just to breathe.” Marquis, a Children’s Hospital Boston patient, is describing an acute asthma attack—a scenario that’s all too familiar to seven million U.S. children. The most common chronic childhood disease, asthma causes a narrowing and swelling of the airways in the lungs. With proper management and the correct use of medication...

Ritedose Corp. Recalling Albuterol Sulfate Inhalation Solution

AAFP Health of the Public — Wed, 05 Jan 2011 23:40:00 +0100

A manufacturer's labeling error could lead to patients receiving five times the recommended amount of the bronchodilator albuterol sulfate, which could cause life-threatening side effects and death, according to FDA officials. (Source: AAFP Health of the Public)

Recall of Albuterol Used in Nebulizers

MedicineNet Heart General — Tue, 04 Jan 2011 07:00:00 +0100

Title: Recall of Albuterol Used in NebulizersCategory: Health NewsCreated: 1/4/2011 11:00:00 AMLast Editorial Review: 1/4/2011 (Source: MedicineNet Heart General)

Albuterol Inhalation Solution Recalled Due to Mislabeling

Medscape Pharmacist Headlines — Tue, 04 Jan 2011 01:09:42 +0100

The wrong concentration information embossed on vials of 0.083% albuterol inhalation solution from Ritedose could prompt clinicians to adjust the volume of product upward, leading to a possibly dangerous overdose. Medscape Medical News (Source: Medscape Pharmacist Headlines)

Recall of Albuterol Used in Nebulizers

WebMD Health — Tue, 04 Jan 2011 00:06:07 +0100

The Ritedose Corporation has recalled some single-dose vials of Albuterol Sulfate Inhalation Solution because an incorrect label could lead to a possible overdose. (Source: WebMD Health)

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Albuterol Recalled

Physician's First Watch current issue — Tue, 04 Jan 2011 00:00:00 +0100

(Source: Physician's First Watch current issue)

FDA: Albuterol Sulfate Inhalation Solution Recalled

Modern Medicine — Tue, 04 Jan 2011 00:00:00 +0100

The U.S. Food and Drug Administration and The Ritedose Corporation have notified health care professionals and consumers of a voluntary recall of 0.083 percent Albuterol Sulfate Inhalation Solution, 3 mL in 25, 30, and 60 unit dose vials, as the 2.5 mg/3 mL single use vials are embossed with the incorrect concentration of 0.5 mg/3 mL. This may pose a health risk to patients, which could result in temporary and medically reversible events or even life-threatening events and death. (Source: Modern Medicine)

Albuterol Sulfate Inhalation Solution 0.083%, 3 mL Unit Dose Vials: Recall - Mislabeled Unit Dose Vials

FDA MedWatch — Mon, 03 Jan 2011 20:20:00 +0100

Potenial for dosing error leading to albuterol toxicity. (Source: FDA MedWatch)

The Ritedose Corporation Announces the Voluntary Nationwide Recall of 0.083% Albuterol Sulfate Inhalation Solution, 3 mL Due to Mislabeled Unit Dose Vials

Food and Drug Administration — Mon, 03 Jan 2011 15:27:00 +0100

The Ritedose Corporation is conducting a voluntary recall of 0.083% Albuterol Sulfate Inhalation Solution, 3 mL (in 25, 30, and 60 unit dose vials). This product is a prescription inhalation solution, administered via nebulization, for the treatment and maintenance of acute asthma exacerbations and exercise induced asthma in children and adults. (Source: Food and Drug Administration)

Albuterol Sulfate Inhalation Solution 0.083%, 3 mL Unit Dose Vials: Recall - Mislabeled Unit Dose Vials

Drugs.com - FDA MedWatch Alerts — Mon, 03 Jan 2011 05:00:00 +0100

Audience: Family Practice, Pharmacy, Consumer [Posted 01/03/2011] ISSUE: The Ritedose Corporation is conducting a voluntary recall of 0.083% Albuterol Sulfate Inhalation Solution, 3 mL in 25, 30, and 60 unit dose vials. This product is being... (Source: Drugs.com - FDA MedWatch Alerts)

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Effects of early albuterol (salbutamol) administration on the development of posttraumatic stress symptoms

Psychiatry Research — Wed, 29 Dec 2010 06:16:05 +0100

Abstract: The present study examined whether the use of albuterol within hours of a motor vehicle accident (MVA) impacted subsequent posttraumatic stress symptoms (PTSS). Participants receiving albuterol had less severe overall PTSS and hyperarousal symptoms at 6 weeks and less severe reexperiencing symptoms at 1 year post-MVA than those who did not receive albuterol. (Source: Psychiatry Research)

Influence of gene–gene interactions on response to albuterol therapy

Future Medicine: Pharmacogenomics — Thu, 23 Dec 2010 04:00:48 +0100

Pharmacogenomics , January 2011, Vol. 12, No. 1, Pages 1-3. (Source: Future Medicine: Pharmacogenomics)

ALBUTEROL SULFATEsyrup [TEVA Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 22 Dec 2010 05:00:00 +0100

Updated Date: Dec 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD

Respiratory Medicine — Thu, 16 Dec 2010 00:00:00 +0100

Summary: Study objective: Novel evaluation of protective effect of tiotropium against induced dynamic hyperinflation (DH) during metronome paced hyperventilation (MPH) in moderate COPD.Methods: Prospective, randomized, double-blind, placebo control, crossover study. Lung function measured pre/post MPH at 30 breaths/min for 20 s in 29 (18M) COPD patients (GOLD Stage 2) age 70 ± 9 yr (mean ± SD) before and after 30 days of 18 μg tiotropium bromide vs placebo. Lung CT scored for emphysema (ES).Results: At baseline post 180 μg aerosolized albuterol sulfate, FEV1: 1.8 ± 0.6 L (69 ± 6%pred) and ≥60% predicted in all, and 14 of 29 had FEV1 (L) ≥70% predicted with FEV1/FVC 58 ± 8%. After 29 days + 23 h post tiotropium (trough) there was significant decrease only in FR...

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATE (Albuterol Sulfate And Ipratropium Bromide) Solution [TEVA Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Dec 2010 05:00:00 +0100

Updated Date: Dec 1, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Rx for Bronchiolitis: Hypertonic Saline Without Albuterol

AAP Grand Rounds — Wed, 01 Dec 2010 00:00:00 +0100

(Source: AAP Grand Rounds)

Albuterol Delivery via Intrapulmonary Percussive Ventilator and Jet Nebulizer in a Pediatric Ventilator Model.

Respiratory Care — Wed, 01 Dec 2010 00:00:00 +0100

CONCLUSIONS: The IPV delivered less albuterol than the jet nebulizer when placed at the humidifier. IPV was equivalent to jet nebulizer when placed at the Y-piece. Doubling the V(T) did not increase aerosol delivery. PMID: 21122179 [PubMed - in process] (Source: Respiratory Care)

In-vitro Comparison of 4 Large-Volume Nebulizers in 8 Hours of Continuous Nebulization.

Respiratory Care — Wed, 01 Dec 2010 00:00:00 +0100

CONCLUSIONS: The tested nebulizers had similar performance during the first 5 hours. The nebulizer solution might need to be replaced if treatment is planned for longer period. The Misty Finity and Hope nebulizers had a more consistent solution output. PMID: 21122175 [PubMed - in process] (Source: Respiratory Care)

Albuterol and levalbuterol use and spending in medicare beneficiaries with chronic obstructive pulmonary disease.

The American Journal of Geriatric Pharmacotherapy — Wed, 01 Dec 2010 00:00:00 +0100

Conclusions: In this sample of Medicare beneficiaries with COPD enrolled in Part D, mean annual spending in 2006 was significantly higher for levalbuterol than for albuterol. The differences between levalbuterol and albuterol users in terms of patient characteristics, geographic region, and drug formulation/device type, coupled with the inconclusive evidence for efficacy differences in the literature, highlight the need for further comparative clinical and cost-effectiveness studies of these agents. PMID: 21356506 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy)