MedWorm: Aleve

Naproxen: Photosensitivity: 2 case reports

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

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VIMOVO (Naproxen And Esomeprazole Magnesium) Tablet, Delayed Release [AstraZeneca LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 02 Feb 2012 05:00:00 +0100

Updated Date: Feb 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NAPROXEN DELAYED RELEASE (Naproxen) Tablet [Camber Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 02 Feb 2012 05:00:00 +0100

Updated Date: Feb 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry.

Talanta — Mon, 30 Jan 2012 05:00:00 +0100

Authors: Yu Y, Wu L Abstract Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been acknowledged as emerging pollutants due to widespread contamination in environment. A rapid and reliable analytical method, based on ultrasonic extraction, clean up on Envi-carb cartridge, derivatized with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA), and analyzed by gas chromatography-mass spectrometry (GC-MS), was developed for determination of 4 EDCs (bisphenol A, estrone, nonylphenol and octylphenol) and 10 PPCPs (acetylsalicylic acid, carbamazepine, clofibric acid, diclofenac, gemfibrozil, ibuprofen, ketoprofen, naproxen, paracetamol and triclosan) in sewage sludge. Mean recoveries of the target analytes, at different spike level...

Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondylarthritis) and gastrointestinal or liver comorbidity.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: On the basis of the current review, there is scant evidence to guide clinicians about how gastrointestinal or liver comorbidities should influence the choice of pain treatment in patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis or other spondylarthritis. Based upon additional studies that included a mixed population of participants with a range of rheumatic conditions, NSAIDs should be used cautiously in patients with inflammatory arthritis and a history of gastrointestinaI comorbidity as there is consistent evidence that they may be at increased risk. PMID: 22258995 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Effects of naproxen on the hypobaric hypoxia-induced immune changes in male rats

European Journal of Applied Physiology — Tue, 24 Jan 2012 07:33:09 +0100

Abstract Some cell-mediated immune responses are altered in hypobaric hypoxic (HH) condition in rats. Prostaglandins (PGs) are increased in hypobaric hypoxia and non-steroidal anti-inflammatory drugs are used to facilitate acclimatization in high altitude by inhibiting PGs. The present study explores the role of PGs in hypobaric hypoxia-induced immune responses by inhibiting its synthesis with different doses of naproxen. The rats were exposed to HH condition at 18,000 ft in a simulated chamber for 8 h/day for 6 days. The phagocytic activity of circulating blood WBC, measured by fluorescein isothiocyanate-tagged bacterial cell, was increased in HH and this change was blocked after administration of naproxen. There was reduction of natural killer cell cytotox...

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Naproxen: Fixed drug eruption: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

(Source: Reactions)

VIMOVO (Naproxen And Esomeprazole Magnesium) Tablet, Delayed Release [AstraZeneca LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 20 Jan 2012 05:00:00 +0100

Updated Date: Jan 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmaceutical removal in tropical subsurface flow constructed wetlands at varying hydraulic loading rates.

Chemosphere — Thu, 19 Jan 2012 05:00:00 +0100

Authors: Zhang DQ, Gersberg RM, Hua T, Zhu J, Tuan NA, Tan SK Abstract Determining the fate of emerging organic contaminants in an aquatic ecosystem is important for developing constructed wetlands (CWs) treatment technology. Experiments were carried out in subsurface flow CWs in Singapore to evaluate the fate and transport of eight pharmaceutical compounds. The CW system included three parallel horizontal subsurface flow CWs and three parallel unplanted beds fed continuously with synthetic wastewater at different hydraulic retention times (HRTs). The findings of the tests at 2-6d HRTs showed that the pharmaceuticals could be categorized as (i) efficiently removed compounds with removal higher than 85% (ketoprofen and salicylic acid); (ii) moderately removed compounds with removal ...

Short answer question case series: diagnosis and management of glaucoma

Emergency Medicine Journal — Wed, 11 Jan 2012 05:00:00 +0100

Case vignette A 40-year-old woman with history of hypertension and migraines presents with a complaint of headache. Two days prior to presentation she began to experience a left-sided, throbbing headache that radiated to the right and was accompanied by blurring of left eye vision and nausea. The blurred vision and headache were exacerbated by bright light, consistent with prior migraine attacks. She took her usual dose of naproxen with resolution of her nausea but still had a mild headache and blurred left eye vision. Two hours prior to presentation she walked outside and experienced worsening of her headache upon exposure to the sunlight, but without concomitant change in her vision or nausea. Aleve did not improve her symptoms, so she decided to present to the emergency department. Her ...

Pharmacological Synergy: The Next Frontier on Therapeutic Advancement for Migraine

Headache: The Journal of Head and Face Pain — Fri, 06 Jan 2012 05:00:00 +0100

The burden of migraine significantly impacts the individual sufferer, their families, the workplace, and society. The World Health Organization has identified migraine as an urgent public health priority and has initiated a global initiative to reduce the burden of migraine. Underlying the World Health Organization initiative is the need to discover means of optimizing migraine treatments and make them accessible to the broader portion of the world population.Development of acute migraine medications over the past several decades has largely centered on engineering highly specific receptor molecules that alter migraine pathophysiological mechanisms to abort or reverse the acute attack of migraine. The first product of this line of discovery was sumatriptan and heralded as a landmark therap...

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Pharmacological Synergy: The Next Frontier on Therapeutic Advancement for Migraine.

Headache — Fri, 06 Jan 2012 05:00:00 +0100

Authors: Blumenfeld A, Gennings C, Cady R Abstract The burden of migraine significantly impacts the individual sufferer, their families, the workplace, and society. The World Health Organization has identified migraine as an urgent public health priority and has initiated a global initiative to reduce the burden of migraine. Underlying the World Health Organization initiative is the need to discover means of optimizing migraine treatments and make them accessible to the broader portion of the world population. Development of acute migraine medications over the past several decades has largely centered on engineering highly specific receptor molecules that alter migraine pathophysiological mechanisms to abort or reverse the acute attack of migraine. The first product of this line of...

NAPROXEN SODIUMtablet [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 05 Jan 2012 05:00:00 +0100

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia

AJP: Heart and Circulatory Physiology — Tue, 03 Jan 2012 05:00:00 +0100

We examined the effects of nonselective and selective COX inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Twenty-four intact male Yorkshire swine underwent left circumflex ameroid constrictor placement and were subsequently given either no drug (HCC; n = 8), a nonselective COX inhibitor (440 mg/day naproxen; HCNS; n = 8), or a selective COX-2 inhibitor (200 mg/day celecoxib; HCCX; n = 8). After 7 wk, myocardial functional was measured and myocardium from the nonischemic ventricle and ischemic area-at-risk (AAR) were analyzed. Regional function as measured by segmental shortening was improved in the AAR of HCCX compared with HCC. There was no significant difference in perfusion to the nonischemic ventricle between groups, but myocardial perfu...

Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia.

Chemosphere — Tue, 03 Jan 2012 05:00:00 +0100

Authors: Gracia-Lor E, Sancho JV, Serrano R, Hernández F Abstract A survey on the presence of pharmaceuticals in urban wastewater of a Spanish Mediterranean area (Castellon province) was carried out. The scope of the study included a wide variety of pharmaceuticals belonging to different therapeutical classes. For this purpose, 112 samples, including influent and effluent wastewater, from different conventional wastewater treatment plants were collected. Two monitoring programmes were carried out along several seasons. The first was in June 2008 and January 2009, and the second in April and October 2009. During the first monitoring, the occurrence of 20 analytes in 84 urban wastewater samples (influent and effluent) was studied. The selection of these pharmaceuticals was mainly ba...

How To Cure A New Year's Hangover

Health News from Medical News Today — Sun, 01 Jan 2012 08:00:00 +0100

Loyola University Health System family physician Dr. Aaron Michelfelder offers the following tips on how to avoid the misery of a New Year's hangover: Before the party: -- Plan to drink moderately -- a maximum of five drinks for men and three drinks for women during a minimum three-hour period. -- To prevent inflammation, take an anti-inflammatory drug such as ibuprofen or Aleve. During the party: -- Eat first, and then drink, not the other way around. Food slows the absorption of alcohol. -- Drink slowly. -- To prevent dehydration, drink a glass of water after each alcoholic drink... (Source: Health News from Medical News Today)

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Sumatriptan-naproxen may offer benefits over butalbital for migraine

Modern Medicine — Tue, 27 Dec 2011 05:00:00 +0100

NEW YORK (Reuters Health) - A pill combining sumatriptan and naproxen (Treximet; (Source: Modern Medicine)

UP AND UP NAPROXEN SODIUM (Naproxen Sodium) Tablet, Film Coated [Target Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 21 Dec 2011 05:00:00 +0100

Updated Date: Dec 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Biofilm controlled sorption of selected acidic drugs on river sediments characterized by different organic carbon content.

Chemosphere — Tue, 20 Dec 2011 05:00:00 +0100

Authors: Dobor J, Varga M, Záray G Abstract The sorption process of selected non-steroidal anti-inflammatory drugs (ibuprofen, naproxen, ketoprofen, diclofenac) on biofilm covered river sediments were investigated in laboratory. In the course of the experiments, the effect of pH of aqueous phase, the effect of TOC (total organic carbon) content of biofilm on the sorption processes were studied. The determination of concentration of drugs was performed by gas chromatography mass spectrometry (GC-MS) both in liquid and solid phases. The pseudo-first-order rate constant of the sorption was found to be 83min(-1). The effect of pH on the sorption of diclofenac was significantly lower than the obtained values in case of the other three drugs. The calculated K(d) (sorption coefficient) v...

Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain).

Chemosphere — Mon, 19 Dec 2011 05:00:00 +0100

This study covered a series of emerging pollutants of different classes, including pharmaceuticals, neutral and acidic organophosphorus flame retardant/plasticizers (OPs), triclosan, phenoxy-herbicides, insect repellents and UV filters. From the total set of 53 compounds, 19 were found in raw wastewater with median concentrations higher than 0.1μgL(-1). Among them, salicylic acid, ibuprofen and the UV filter benzophenone-4 (BP-4) were the most concentrated, exceeding the 1μgL(-1) median value. Subsequently, 11 of these contaminants are not efficiently enough removed in the small WWTPs tested and their median concentrations in effluents still surpassed the 0.1μgL(-1), so that they can spread through surface water. These chemicals are the pharmaceuticals naproxen, diclofenac and atenolol;...

The presence of acidic and neutral drugs in treated sewage effluents and receiving waters in the Cornwallis and Annapolis River watersheds and the Mill CoveSewage Treatment Plant in Nova Scotia, Canada.

Environmental Research — Fri, 16 Dec 2011 05:00:00 +0100

Authors: Crouse BA, Ghoshdastidar AJ, Tong AZ Abstract Pharmaceuticals are designed to have physiological effects on target organisms. Their presence and effect in aquatic ecosystems in the Annapolis Valley in Nova Scotia is relatively unknown. Over-the-counter (OTC) and prescription drugs are continually introduced to aquatic ecosystems through treated sewage effluent outflows into rivers and other bodies of water. Fouracidic and two neutral pharmaceuticals were monitored in the effluents from nine sewage treatment plants in the Annapolis Valley and Halifax Regional Municipality (HRM) in Nova Scotia. Naproxen and ibuprofen, two highly used OTC drugs, were the most prominent and were detected at high ng/L to low μg/L levels. Caffeine, salicylic acid (a metabolite of acetylsalicyli...

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ALL DAY RELIEF (Naproxen Sodium) Tablet, Film Coated [Kroger Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 15 Dec 2011 05:00:00 +0100

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTHY ACCENTS ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet, Film Coated [DZA Brands LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 15 Dec 2011 05:00:00 +0100

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NSAID use among women and the risk of birth defects: case control study

NeLM - News — Thu, 15 Dec 2011 05:00:00 +0100

Source: American Journal of Obstetrics and Gynecology Area: News This population-based, case-control study examined whether use of NSAIDs in early pregnancy was associated with a range of structural birth defects. Data were obtained from the National Birth Defects Prevention Study (NBDPS), an ongoing case-control surveillance study designed to identify infants with major birth defects and evaluate genetic and environmental risk factors. Case infants for the study were identified from the state birth defect surveillance system of ten US states. Cases include live births, stillbirths of 20 weeks or longer gestation or greater than 500 grams, or elective terminations with any of more than 30 eligible birth defects groups diagnosed in the first year of life. The following findings ...

NAPROXEN SODIUMtablet [Rite Aid Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 14 Dec 2011 05:00:00 +0100

Updated Date: Dec 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BERKLEY AND JENSEN NAPROXEN SODIUM (Naproxen Sodium) Tablet, Film Coated [BJWC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 14 Dec 2011 05:00:00 +0100

Updated Date: Dec 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CARE ONE ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet, Film Coated [American Sales Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 12 Dec 2011 05:00:00 +0100

Updated Date: Dec 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro release from oil injectables for intra-articular administration: Importance of interfacial area, diffusivity and partitioning.

European Journal of Pharmaceutical Sciences — Fri, 09 Dec 2011 05:00:00 +0100

Authors: Thing M, Larsen C, Ostergaard J, Jensen H, Larsen SW Abstract Most in vitro methods for evaluating parenteral oil based depots are focusing on intramuscular or subcutaneous injection. For intra-articular injection other mechanisms may control the overall drug release rate due to a relatively smaller interfacial area and longer transport distance of the drug substance in the oil to the oil-synovial fluid interface. In the current work, an in vitro model for testing drug release from oil solutions intended for intra-articular injection was evaluated. The release of the model drugs naproxen, piroxicam and ropivaciane from a well-defined surface area of the lipophilic solutions were followed using an in vitro model based on a modified USP II paddle apparatus with modest agitat...

NAPROXEN (Naproxen ) Tablet [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Dec 2011 05:00:00 +0100

Updated Date: Dec 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALL DAY RELIEF (Naproxen Sodium) Tablet [Meijer Distribution Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Dec 2011 05:00:00 +0100

Updated Date: Dec 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Identification of Cytokines and Signaling Proteins Differentially Regulated by Sumatriptan/Naproxen.

Headache — Thu, 08 Dec 2011 05:00:00 +0100

Conclusion.- We found that the combination of sumatriptan/naproxen was effective in blocking capsaicin stimulation of pro-inflammatory proteins implicated in the development of peripheral and central sensitization in response to capsaicin activation of trigeminal neurons. Based on our findings that sumatriptan and naproxen regulate expression of different proteins in trigeminal ganglia and the spinal trigeminal nucleus, we propose that these drugs function on therapeutically distinct cellular targets to suppress inflammation and pain associated with migraine. PMID: 22150557 [PubMed - as supplied by publisher] (Source: Headache)

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NAPROXEN SODIUMtablet [Granules India Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 07 Dec 2011 05:00:00 +0100

Updated Date: Dec 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EQUATE NAPROXEN SODIUM (Naproxen Sodium) Capsule, Liquid Filled [Wal-Mart Stores Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 05 Dec 2011 05:00:00 +0100

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

VIMOVO (Naproxen And Esomeprazole Magnesium) Tablet, Delayed Release [AstraZeneca LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 05 Dec 2011 05:00:00 +0100

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TREXIMET (Sumatriptan And Naproxen Sodium) Tablet, Film Coated [GlaxoSmithKline LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Dec 2011 05:00:00 +0100

Updated Date: Dec 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTH MART NAPROXEN SODIUM (Naproxen Sodium) Capsule, Liquid Filled [McKesson]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Dec 2011 05:00:00 +0100

Updated Date: Dec 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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TREXIMET (Sumatriptan And Naproxen Sodium) Tablet, Film Coated [GlaxoSmithKline LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NAPRELAN (Naproxen Sodium) Tablet, Film Coated, Extended Release [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

HEALTH MART NAPROXEN SODIUM (Naproxen Sodium) Tablet, Film Coated [McKesson]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 29 Nov 2011 05:00:00 +0100

Updated Date: Nov 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NAPROXEN SODIUMtablet, Film Coated, Extended Release [SPIRIT PHARMACEUTICALS,LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 29 Nov 2011 05:00:00 +0100

Updated Date: Nov 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.

Toxicology in Vitro — Sat, 26 Nov 2011 05:00:00 +0100

In conclusion, we demonstrate the use of yeast to investigate the mechanisms underlying the toxicity of structurally related drugs. PMID: 22138569 [PubMed - as supplied by publisher] (Source: Toxicology in Vitro)

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Occurrence of endocrine disrupters and selected pharmaceuticals in Aisonas River (Greece) and environmental risk assessment using hazard indexes.

Environmental Science and Pollution Research International — Fri, 25 Nov 2011 05:00:00 +0100

Authors: Stasinakis AS, Mermigka S, Samaras VG, Farmaki E, Thomaidis NS Abstract PURPOSE: The presence of four phenolic endocrine disrupting compounds (EDCs: nonylphenol [NP], NP monoethoxylate[NP1EO], bisphenol A [BPA], triclosan, [TCS]) and four nonsteroidal anti-inflammatory drugs (NSAIDs: ibuprofen[IBF], ketoprofen [KFN], naproxen [NPX], diclofenac [DCF]) in a Greek river receiving treated municipal wastewater was investigated in this study. METHODS: Samples were taken from four different points of the river and from the outlet of a sewage treatment plant (STP) during six sampling campaigns, and they were analyzed using gas chromatography-mass spectrometry. RESULTS: According to the results, EDCs were dete...

Activation of the farnesoid‐X receptor protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs in mice

British Journal of Pharmacology — Tue, 22 Nov 2011 06:47:25 +0100

CONCLUSIONS AND IMPLICATIONS FXR was essential to maintain gastric and intestinal mucosal barriers. FXR agonists protected against gastric injury caused by ASA and NSAIDs by a CSE‐mediated mechanism. (Source: British Journal of Pharmacology)

Sumatriptan‐Naproxen and Butalbital: A Double‐Blind, Placebo‐Controlled Crossover Study

Headache: The Journal of Head and Face Pain — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions.— This study primarily included subjects whose migraines significantly impacted their lives. Before the study, these subjects used butalbital‐containing medications as part of their current migraine treatment regimen and were satisfied with it, suggesting they were butalbital responders who had found a workable treatment strategy for themselves. When treated with SumaRT/Nap versus BCM in this study, however, a significant proportion of subjects reported better treatment outcomes for themselves for both migraine pain and associated symptoms. Use of SumaRT/Nap was also associated with less rescue medication use and a longer time before use of rescue medication compared with both BCM and placebo. (Source: Headache: The Journal of Head and Face Pain)

Sumatriptan-Naproxen and Butalbital: A Double-Blind, Placebo-Controlled Crossover Study.

Headache — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions.- This study primarily included subjects whose migraines significantly impacted their lives. Before the study, these subjects used butalbital-containing medications as part of their current migraine treatment regimen and were satisfied with it, suggesting they were butalbital responders who had found a workable treatment strategy for themselves. When treated with SumaRT/Nap versus BCM in this study, however, a significant proportion of subjects reported better treatment outcomes for themselves for both migraine pain and associated symptoms. Use of SumaRT/Nap was also associated with less rescue medication use and a longer time before use of rescue medication compared with both BCM and placebo. PMID: 22103635 [PubMed - as supplied by publisher] (Source: Headache)

Racemic Naproxen: A Multidisciplinary Structural and Thermodynamic Comparison with the Enantiopure Form

Crystal Growth and Design — Thu, 17 Nov 2011 18:47:51 +0100

Crystal Growth & DesignDOI: 10.1021/cg201203u (Source: Crystal Growth and Design)

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Photosensitivity induced by naproxen

Photodermatology, Photoimmunology and Photomedicine — Thu, 17 Nov 2011 10:59:49 +0100

We present two cases of systemic photosensitivity due to naproxen that presented as photodistributed erythema multiforme (EM) and lichenoid photodermatitis (LP). Although naproxen is a commonly used nonsteroidal antinflammatory drug and has the capacity of causing systemic photosensitivity, there are very few reports about it in the literature. The diagnosis was suspected by the recent ingestion of the drug and the photodistribution of the lesions. A positive photopatch test in the first patient and the normalization of the MED‐UVB after discontinuing naproxen in the second patient supported the diagnosis. (Source: Photodermatology, Photoimmunology and Photomedicine)

NAPROXEN SODIUM (Naproxen) Tablet [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Nov 2011 05:00:00 +0100

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of the Migraine Treatment Sumatriptan/Naproxen Sodium on Blood Pressure Following Long‐Term Administration

The Journal of Clinical Hypertension — Fri, 11 Nov 2011 05:00:00 +0100

Anti‐inflammatory and pain therapies have been associated with blood pressure (BP) destabilization. Hence, the effects on BP of sumatriptan/naproxen sodium in fixed‐dose combination, sumatriptan 85 mg, and naproxen sodium 500 mg administered intermittently for the acute treatment of migraine attacks were assessed. Patients with migraine with or without aura and no history of hypertension were randomized to sumatriptan/naproxen sodium (n=135), sumatriptan (n=136), or naproxen sodium (n=136) to treat migraine attacks for 6 months in a double‐blind, parallel‐group trial. Following a treated migraine attack, patients performed 2 consecutive days of self‐measured BPs beginning ≥24 hours after the last dose of study medication and transmitted them by a transtelephonic modem. Th...

Impact of a Fixed-Dose Combination of Naproxen and Esomeprazole Magnesium on Serum Thromboxane B(2) Inhibition by Low-Dose Aspirin Over 5 Days in Healthy Adults: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Noninferiority Trial.

Clinical Therapeutics — Wed, 09 Nov 2011 05:00:00 +0100

CONCLUSIONS: This pilot investigation suggests that LDA coadministered with naproxen/esomeprazole magnesium is noninferior to LDA alone for platelet COX-1 inhibition, as measured by serum TXB(2) concentration, in healthy volunteers. ClinicalTrials.gov identifier: NCT01094483. PMID: 22078153 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

SMC does not recommend naproxen + esomeprazole combination product (Vimovo®)

NeLM - Drug Specific Reviews — Tue, 08 Nov 2011 05:00:00 +0100

Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) does not recommend the use of naproxen 500mg/esomeprazole 20mg (Vimovo®) within NHS Scotland for the symptomatic treatment of osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS), in patients who are at risk for developing NSAID-associated gastric and/or duodenal ulcers and where treatment with lower doses of naproxen or of other NSAIDs is not considered sufficient. The Drug Advice notes that combined naproxen/esomeprazole has been shown in studies to be associated with a lower incidence of endoscopic gastric ulcers than NSAID alone, and with similar improvements in pain and functioning compared to a cyclo-oxygenase-2 (COX-2) ...

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Plasma and Cerebrospinal Fluid Pharmacokinetics of Naproxen in Children.

The Journal of Clinical Pharmacology — Tue, 08 Nov 2011 05:00:00 +0100

Authors: Välitalo P, Kumpulainen E, Manner M, Kokki M, Lehtonen M, Hooker AC, Ranta VP, Kokki H Abstract The aim of this study was to characterize pediatric pharmacokinetics and central nervous system exposure of naproxen after oral administration. The pharmacokinetics of naproxen was studied in 53 healthy children aged 3 months to 12 years undergoing surgery with spinal anesthesia. Children received preoperatively a single dose of 10 mg/kg oral naproxen suspension. A single cerebrospinal fluid (CSF) sample (n = 52) was collected at the induction of anesthesia, and plasma samples (n = 270) were collected before, during, and after the operation (up to 51 hours after administration). A population pharmacokinetic model was built using the NONMEM software. Naproxen concentrations in p...

NSAID-sensitive antihistamine-induced urticaria/angioedema.

Journal of Investigational Allergology and Clinical Immunology — Mon, 07 Nov 2011 15:00:03 +0100

We describe the first case of a possible new subset of antihistamine urticaria, and suggest calling this NSAID-sensitive antihistamine-induced urticaria/angioedema. PMID: 21995184 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)

Stroke risk and NSAIDs: an Australian population-based study

NeLM - News — Mon, 07 Nov 2011 05:00:00 +0100

Source: The Medical Journal of Australia Area: News According to the results of a retrospective cohort study published in the Medical Journal of Australia, incident use of NSAIDs was associated with an increased stroke risk. The absolute risk of stroke was low however; and the resultant absolute increase was therefore also small. The authors note that most of the studies evaluating the use of NSAIDs and the risk of cardiovascular events have looked at a combined endpoint; few have examined the specific association of their use with the risk of stroke. They analysed data from the Department of Veterans' Affairs administrative claims database (from 2001-2008) to determine the association between hospitalisation for stroke and the prescription of NSAIDs in the Au...

Sumatriptan and Naproxen Sodium for Migraine in AdolescentsSumatriptan and Naproxen Sodium for Migraine in Adolescents

Medscape Today Headlines — Thu, 03 Nov 2011 10:20:19 +0100

The combination of sumatriptan and naproxen sodium has been demonstrated to be highly effective against migraine in adults. Does it offer the same benefit--and safety profile--for adolescents? Headache (Source: Medscape Today Headlines)

NAPROXEN SODIUMtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 03 Nov 2011 05:00:00 +0100

Updated Date: Nov 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Biological evaluation of cobalt(II) complexes with non-steroidal anti-inflammatory drug naproxen.

Journal of Inorganic Biochemistry — Thu, 03 Nov 2011 04:00:00 +0100

Authors: Dimiza F, Papadopoulos AN, Tangoulis V, Psycharis V, Raptopoulou CP, Kessissoglou DP, Psomas G Abstract Cobalt(II) complexes with the non-steroidal anti-inflammatory drug naproxen in the presence or absence of nitrogen-donor heterocyclic ligands (pyridine, 2,2'-bipyridine or 1,10-phenanthroline) have been synthesized and characterized with physicochemical and spectroscopic techniques. The deprotonated naproxen acts as monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen. The crystal structure of [bis(aqua)bis(naproxenato)bis(pyridine)cobalt(II)], 2 has been determined by X-ray crystallography. The EPR spectrum of complex 2 in frozen solution reveals that it retains its structure. UV study of the interaction of the complexes with calf-thymus DNA (CT DNA...

Stereoselective Inhibitory Effect of Flurbiprofen, Ibuprofen and Naproxen on Human Organic Anion Transporters hOAT1 and hOAT3

Biopharmaceutics and Drug Disposition — Tue, 01 Nov 2011 04:00:00 +0100

In this study, we performed uptake experiments using Xenopus laevis oocytes to assess stereoselectivity in the inhibitory characteristics of flurbiprofen, ibuprofen and naproxen against hOAT1 and hOAT3. Uptake of p‐aminohippurate by hOAT1 was inhibited by each enantiomer of the three NSAIDs, and the inhibitory effect was superior in each (S)‐enantiomer around 10 μM. The apparent 50% inhibitory concentrations were estimated to be 0.615 μM for (S)‐flurbiprofen, 2.84 μM for (S)‐ibuprofen and 1.93 μM for (S)‐naproxen, and these values were significantly lower than those of the respective (R)‐enantiomers [(R)‐flurbiprofen: 2.35 μM, (R)‐ibuprofen: 6.14 μM, (R)‐naproxen: 5.26 μM]. Furthermore, the (S)‐NSAIDs at 3 μM reduced methotrexate accumulation in ...

Identification of Cytokines and Signaling Proteins Differentially Regulated by Sumatriptan/Naproxen

Headache: The Journal of Head and Face Pain — Tue, 01 Nov 2011 04:00:00 +0100

Conclusion.— We found that the combination of sumatriptan/naproxen was effective in blocking capsaicin stimulation of pro‐inflammatory proteins implicated in the development of peripheral and central sensitization in response to capsaicin activation of trigeminal neurons. Based on our findings that sumatriptan and naproxen regulate expression of different proteins in trigeminal ganglia and the spinal trigeminal nucleus, we propose that these drugs function on therapeutically distinct cellular targets to suppress inflammation and pain associated with migraine. (Source: Headache: The Journal of Head and Face Pain)

Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia.

American Journal of Physiology. Heart and Circulatory Physiology — Fri, 28 Oct 2011 04:00:00 +0100

We examined the effects of nonselective and selective COX inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. 24 intact male Yorkshire swine underwent left circumflex ameroid constrictor placement, and were subsequently given either no drug (HCC, n=8), non-selective COX-inhibitor (naproxen 440 mg/day, HCNS, n=8), or selective COX-2 inhibitor (celecoxib 200 mg/day, HCCX, n=8). After 7 weeks, myocardial functional was measured and myocardium from the nonischemic ventricle (NV) and ischemic area-at-risk (AAR) analyzed. Regional function as measured by segmental shortening was improved in the AAR of HCCX compared to HCC. There was no significant difference in perfusion to the NV between groups, but myocardial perfusion in the AAR was significantly i...

Naproxen: Gastric ulcer leading to gastrocolic fistula: case report

Reactions — Wed, 26 Oct 2011 13:05:18 +0100

(Source: Reactions)

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Naproxen: Anaphylaxis: case report

Reactions — Wed, 26 Oct 2011 13:05:18 +0100

(Source: Reactions)

Naproxen sodium: Kounis syndrome: case report

Reactions — Wed, 26 Oct 2011 13:05:18 +0100

(Source: Reactions)

Naproxen Cocrystals with Pyridinecarboxamide Isomers

Crystal Growth and Design — Wed, 26 Oct 2011 04:43:36 +0100

Crystal Growth & DesignDOI: 10.1021/cg2009946 (Source: Crystal Growth and Design)

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord

Pain — Wed, 26 Oct 2011 04:00:00 +0100

Summary: Nerve injury significantly increases endogenous cholecystokinin (CCK) in the rostral ventromedial medulla (RVM), and CCK drives descending facilitatory pathways from the RVM in naïve animals to increase spinal prostaglandin-E2 and serotonin (5-hydoxytryptophan/5-hydroxyindoleacetic acid).Abstract: Cholecystokinin (CCK) has been suggested to be both pro-nociceptive and “anti-opioid” by actions on pain-modulatory cells within the rostral ventromedial medulla (RVM). One consequence of activation of RVM CCK2 receptors may be enhanced spinal nociceptive transmission; but how this might occur, especially in states of pathological pain, is unknown. Here, in vivo microdialysis was used to demonstrate that levels of RVM CCK increased by approximately 2-fold after ligation of L5/L6 spi...

Naproxen as Prophylaxis against Atrial Fibrillation after Cardiac Surgery: The NAFARM Randomized Trial

The American Journal of Medicine — Sun, 23 Oct 2011 00:57:20 +0100

Conclusions: Postoperative use of naproxen did not reduce the incidence of atrial fibrillation but decreased its duration, in a limited sample of patients after CABG surgery. There was a significant increase in acute renal failure in patients receiving naproxen 275 mg twice daily. Our study does not support the routine use of naproxen after CABG surgery for the prevention of atrial fibrillation. (Source: The American Journal of Medicine)

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Anticoagulants/antiplatelets/naproxen sodium: Gastrointestinal haemorrhage in an elderly patient: case report

Reactions — Sat, 22 Oct 2011 05:54:13 +0100

(Source: Reactions)

NAPROXEN (Naproxen) Tablet [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 21 Oct 2011 05:00:00 +0100

Updated Date: Oct 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cool Image: A Possible New Way to Ease Pain

NIGMS Biomedical Beat — Thu, 20 Oct 2011 13:00:00 +0100

In this image, a mass of spinal nerve cells (green) includes the enzyme COX-2 (red). Drugs called NSAIDs—including ibuprofen (such as Advil®) and naproxen (such as Aleve®)—relieve pain and inflammation in part by acting on COX-2. Scientists thought that NSAIDs with a "left-handed" molecular structure do the hard work by stopping COX-2 from making prostaglandins. On the downside, NSAIDs can increase the risk of gastrointestinal and possibly cardiovascular problems. A recent study revealed that right-handed NSAIDs may reduce pain by stopping COX-2 from breaking down natural painkillers called endocannabinoids. The finding could lead to effective new drugs that have fewer side effects. (Source: NIGMS Biomedical Beat)

Risk of ST versus non-ST elevation myocardial infarction associated with non-steroidal anti-inflammatory drugs

Heart — Thu, 20 Oct 2011 04:00:00 +0100

Conclusions Our study shows that the MI risk modification associated with NSAID is limited to NSTEMI. (Source: Heart)

Effect of Carboxylic Acid on Micelles of an Neutral Amphiphilic Dendro-Calix[4]arene

RSC - Organic Biomolecular Chemistry — Wed, 19 Oct 2011 20:41:29 +0100

Org. Biomol. Chem., 2011, Accepted ManuscriptDOI: 10.1039/C1OB06358H, PaperYan-Song Zheng, Hong Huang, Dong-Mi Li, Weizhou Wang, Yi-Chang Chen, khalid Khan, Song SongAn amphiphilic calix[4]arene bearing branched 3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamide groups on the upper rim was synthesized. This derivation increased the solubility of Naproxen and Ibuprofen in water through hydrogen bonding and - stacking....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

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TREXIMET (Sumatriptan Succinate And Naproxen Sodium) Tablet, Film Coated [GlaxoSmithKline LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 19 Oct 2011 05:00:00 +0100

Updated Date: Oct 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacy of transcutaneous electrical nerve stimulation for pain relief in women undergoing office endometrial biopsy

Archives of Gynecology and Obstetrics — Tue, 18 Oct 2011 15:58:14 +0100

Conclusions TENS appears to be successful in decreasing pain only after the procedure undergoing office endometrial biopsy. It can be used as a simple, cheap, safe, and effective pain relief method. Content Type Journal ArticleCategory General GynecologyPages 1-6DOI 10.1007/s00404-011-2111-7Authors Mehmet Yilmazer, Department of Obstetrics and Gynecology, Afyonkarahisar University Faculty of Medicine, Afyonkarahisar Kocatepe Universitesi, Tip Fakültesi, Kadin Hastaliklari ve Dogum AD, Izmir Yolu, Afyonkarahisar, TurkeySeda Kose, Department of Obstetrics and Gynecology, Afyonkarahisar University Faculty of Medicine, Afyonkarahisar Kocatepe Universitesi, Tip Fakültesi, Kadin Hastaliklari ve Dogum AD, Izmir Yolu, Afyonkarahisar, TurkeyDagıstan Tolga Arioz, Department...

Less CV risk with naproxen and low-dose ibuprofen

Reactions — Wed, 12 Oct 2011 06:03:59 +0100

(Source: Reactions)

Erratum

Journal of Oral and Maxillofacial Surgery — Mon, 10 Oct 2011 04:00:00 +0100

In “Analgesic and Anti-Inflammatory Effects of Oxaprozin and Naproxen Sodium After Removal of Impacted Lower Third Molars: A Randomized, Double-Blind, Placebo-Controlled Crossover Study” (Kara et al., J Oral Maxillofac Surg 68:1018-1024) the author's name “Fatih İnce” should be corrected to: M. Fatih İnci. (Source: Journal of Oral and Maxillofacial Surgery)

Rofecoxib and Clinically Significant Upper and Lower Gastrointestinal Events Revisited Based on Documents From Recent Litigation.

The American Journal of the Medical Sciences — Fri, 07 Oct 2011 04:00:00 +0100

CONCLUSION:: Examination and reanalysis of unpublished data regarding rofecoxib has failed to confirm a safety advantage of rofecoxib over traditional nonsteroidal anti-inflammatory drugs in terms of complicated upper or lower GI events. PMID: 21986300 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

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Cotrimoxazole/lisinopril/naproxen: Hyperkalaemia leading to ECG abnormalities in an elderly patient: case report

Reactions — Mon, 03 Oct 2011 06:00:13 +0100

(Source: Reactions)

Stroke risk and NSAIDs: a systematic review of observational studies

Pharmacoepidemiology and Drug Safety — Mon, 03 Oct 2011 04:00:00 +0100

ConclusionThis meta‐analysis supports an increased risk of ischemic stroke with the current use of rofecoxib and diclofenac. Additional studies are required to evaluate most individual NSAIDS, the effect of dose and duration, and the subtypes of stroke. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Cardiovascular Risks Of Common NSAIDs: New Analysis

Health News from Medical News Today — Thu, 29 Sep 2011 07:00:00 +0100

An updated study published in this week's PLoS Medicine gives some new information on the cardiovascular risks of non-steroidal anti-inflammatory drugs (NSAIDs) and suggests that among these commonly used drugs, naproxen and low dose ibuprofen are least likely to increase cardiovascular risk whereas diclofenac, even in doses available without prescription, elevates risk... (Source: Health News from Medical News Today)

SMART SENSE NAPROXEN SODIUM (Naproxen Sodium) Tablet [Kmart Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 29 Sep 2011 05:00:00 +0100

Updated Date: Sep 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Two NSAIDs Have Better CV Profile than Others (CME/CE)

MedPage Today Public Health — Wed, 28 Sep 2011 20:44:04 +0100

(MedPage Today) -- Although there is an established cardiovascular risk associated with nonsteroidal anti-inflammatory drugs, two of them -- naproxen and low-dose ibuprofen -- carry a lower risk than the others, an analysis of observational studies found. (Source: MedPage Today Public Health)

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Heart risk of painkillers examined

NHS News Feed — Wed, 28 Sep 2011 18:05:00 +0100

Conclusion This large review has published some important information on the cardiovascular risks associated with NSAIDs, including the risk associated with different doses and in populations at both high and low risk of cardiovascular events. It raises concerns about some of these risks, in particular the risk associated with the widely used non-prescription drug diclofenac. As its authors point out, it had some limitations. It had to rely on observational studies (rather than randomised controlled trials), which are subject to bias, especially in terms of other factors (confounders) that might influence results. However, the researchers did take steps to minimise this risk. The data in the studies mainly came from large administrative databases and electronic health records, and ma...

Animal Study Warns Of Possible Cardiovascular Risk With NSAID Use

Health News from Medical News Today — Wed, 28 Sep 2011 07:00:00 +0100

A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery. NSAIDs are among the most widely-used drugs today for the treatment of post-operative pain, inflammatory conditions and fever... (Source: Health News from Medical News Today)

Anti-Inflammatory Drugs vs. Cardiovascular Risk

Medical Headlines From Ivanhoe.com — Wed, 28 Sep 2011 05:00:00 +0100

(Ivanhoe Newswire) – An updated study gives new information on the cardiovascular risks of non-steroidal anti-inflammatory drugs (NSAIDs) and suggests that naproxen, a commonly used drug, and low dose ibuprofen are least likely to increase cardiovascular risks. (Source: Medical Headlines From Ivanhoe.com)

Systematic Review: Cardiovascular risk with non-steroidal anti-inflammatory drugs

NeLM - News — Wed, 28 Sep 2011 04:00:00 +0100

Source: PLoS Medicine Area: News PLoS Medicine has featured a systematic review of population-based controlled observational studies that have evaluated the cardiovascular risks associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). A total of 30 case-control studies (reporting 184,946 cardiovascular events) and 21 cohort studies (describing outcomes in more than 2.7million exposed individuals) were identified for inclusion in the systematic review. The following results were reported: . Of the extensively studied drugs (ten or more studies), the highest overall risks were seen with rofecoxib, 1.45 (95% CI 1.33 to 1.59), and diclofenac, 1.40 (1.27 to 1.55), and the lowest with ibuprofen, 1.18 (1.11 to 1.25), and naproxen, 1.09 (1.02 to 1.16)....

Migraine with skin pain is eased by sumatriptan-naproxen

Modern Medicine — Wed, 28 Sep 2011 04:00:00 +0100

NEW YORK (Reuters Health) - The combination of sumatriptan and naproxen is effective when given early for patients with migraine attacks accompanied by cutaneous allodynia, a new study shows. (Source: Modern Medicine)

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Review Confirms CVD Risk With NSAIDS Rofecoxib, DiclofenacReview Confirms CVD Risk With NSAIDS Rofecoxib, Diclofenac

Medscape Today Headlines — Tue, 27 Sep 2011 21:46:31 +0100

The updated review includes data from 31 case-control studies with 184,946 cardiovascular events and 21 cohort studies that include outcomes in more than 2.7 million individuals exposed to the drugs. Of the NSAIDs, the review suggests that naproxen and ibuprofen are the least likely to cause harm. Heartwire (Source: Medscape Today Headlines)

Review confirms CVD risk with rofecoxib but also shows increased risk with diclofenac

theHeart.org — Tue, 27 Sep 2011 21:00:00 +0100

The updated review includes data from 31 case-control studies with 184 946 cardiovascular events and 21 cohort studies that include outcomes in more than 2.7 million individuals exposed to the drugs. Of the NSAIDs, the review suggests that naproxen and ibuprofen are the least likely to cause harm. (Source: theHeart.org)

New Insights Into The Actions Of NSAIDs

Health News from Medical News Today — Tue, 27 Sep 2011 07:00:00 +0100

Ibuprofen, naproxen, and related non-steroidal anti-inflammatory drugs (NSAIDs) - the subjects of years of study - still have some secrets to reveal about how they work. Vanderbilt University investigators have discovered surprising new insights into the actions of NSAIDs. Their findings, reported Sept. 25 in Nature Chemical Biology, raise the possibility of developing a new class of inflammation- and pain-fighting medicines. NSAIDs block the activity of the cyclooxygenase enzymes, COX-1 and COX-2... (Source: Health News from Medical News Today)

A diagnosis of sarcoid arthritis: 'check the tattoos'

Postgraduate Medical Journal — Tue, 27 Sep 2011 04:00:00 +0100

A 36-year-old construction worker described a 3-month history of bilateral pain, stiffness and swelling of the ankles and lower limb joints. Symptoms were worse in the mornings and were associated with generalised fatigue. He had no significant medical history and was taking regular naproxen only with no recorded drug allergies. On examination, cardiovascular and respiratory systems were normal. There was bilateral synovitis of the ankles. Of note, the patient had multiple small papules within the large tattoos on his upper limbs. The lesions were non-tender and were of the same colour as the underlying tattoo ink (figure 1). Figure 1Multiple cutaneous lesions within tattoo ink. A chest radiograph showed bilateral florid hilar lymphadenopathy, with normal lung fields (figure 2). Blood tes...

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

PLoS Medicine — Tue, 27 Sep 2011 04:00:00 +0100

Conclusions This review suggests that among widely used NSAIDs, naproxen and low-dose ibuprofen are least likely to increase cardiovascular risk. Diclofenac in doses available without prescription elevates risk. The data for etoricoxib were sparse, but in pair-wise comparisons this drug had a significantly higher RR than naproxen or ibuprofen. Indomethacin is an older, rather toxic drug, and the evidence on cardiovascular risk casts doubt on its continued clinical use. Please see later in the article for the Editors' Summary (Source: PLoS Medicine)

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Quiz Page October 2011: An Under-recognized Cause of CKD

American Journal of Kidney Diseases — Mon, 26 Sep 2011 17:42:22 +0100

A 47-year-old woman was evaluated for decreasing kidney function. In 2008, serum creatinine level was 0.89 mg/dL (79 μmol/L; estimated glomerular filtration rate [eGFR] >60 mL/min/1.73 m2 [>1 mL/s/1.73 m2], calculated using the 4-variable MDRD [Modification of Diet in Renal Disease] Study equation) and had been stable for 5 years. In 2009, it increased to 1.26 mg/dL (111 μmol/L; eGFR, 49 mL/min/1.73 m2 [0.82 mL/s/1.73 m]), 1.62 mg/dL (143 μmol/L; eGFR, 37 mL/min/1.73 m2 [0.62 mL/s/1.73 m]), and then 2.15 mg/dL (190 μmol/L; eGFR, 26 mL/min/1.73 m2 [0.43 mL/s/1.73 m]) by March 2010. Medical history included anorexia nervosa, deliberate self-harm, left hip fracture, and chronic pain syndrome. Prescribed medications were gabapentin, naproxen, ranitidine, cyclizine, and acetaminophen. (Sour...

Possible cardiovascular risk found with NSAID use, study suggests

ScienceDaily Headlines — Mon, 26 Sep 2011 17:20:20 +0100

A new study suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. (Source: ScienceDaily Headlines)

Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use

EurekAlert! - Medicine and Health — Mon, 26 Sep 2011 04:00:00 +0100

(Lifespan) A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery. (Source: EurekAlert! - Medicine and Health)

Validation and use of in vivo solid phase micro-extraction (SPME) for the detection of emerging contaminants in fish.

Chemosphere — Mon, 26 Sep 2011 04:00:00 +0100

In this study, an in vivo solid phase micro-extraction (SPME) approach was developed and applied to the measurement of a variety of emerging contaminants (carbamazepine, naproxen, diclofenac, gemfibrozil, bisphenol A, fluoxetine, ibuprofen and atrazine) in fish. Our results indicated in vivo SPME was a potential alternative extraction technique for quantitative determination of contaminants in lab exposures and as well after exposure to two municipal wastewater effluents (MWWE), with a major advantage over conventional techniques due to its ability to non-lethally sample tissues of living organisms. PMID: 21955351 [PubMed - as supplied by publisher] (Source: Chemosphere)

Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial

American Journal of Obstetrics and Gynecology — Mon, 26 Sep 2011 04:00:00 +0100

Conclusion: The administration of naproxen resulted in a reduction in bleeding and spotting days compared with placebo. (Source: American Journal of Obstetrics and Gynecology)

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Study puts a new spin on ibuprofen's actions

EurekAlert! - Medicine and Health — Sun, 25 Sep 2011 04:00:00 +0100

(Vanderbilt University Medical Center) Ibuprofen, naproxen, and related non-steroidal anti-inflammatory drugs (NSAIDs) -- the subjects of years of study -- still have some secrets to reveal about how they work.Vanderbilt University investigators have discovered surprising new insights into the actions of NSAIDs. Their findings, reported Sept. 25 in Nature Chemical Biology, raise the possibility of developing a new class of inflammation- and pain-fighting medicines. (Source: EurekAlert! - Medicine and Health)

Ferrous sulfate/ibuprofen/naproxen overdose: Fatal fulminant hepatic failure in an adolescent: case report

Reactions — Thu, 22 Sep 2011 07:55:36 +0100

(Source: Reactions)

ALEVE (Naproxen Sodium) Capsule, Liquid Filled [Bayer HealthCare LLC, Consumer Care]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 22 Sep 2011 05:00:00 +0100

Updated Date: Sep 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The effect of non‐steroidal anti‐inflammatory drugs on the endothelial function of patients with osteoarthritis in short term

APLAR Journal of Rheumatology — Wed, 21 Sep 2011 04:00:00 +0100

Conclusion: Our results suggest that nonselective cyclo‐oxygenase antagonists naproxen and diclofenac have no effect on endothelial function during short‐term use. (Source: APLAR Journal of Rheumatology)

Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002–2006

Fundamental and Clinical Pharmacology — Tue, 20 Sep 2011 04:00:00 +0100

AbstractTo evaluate the safety profile of eight oral nonsteroidal anti‐inflammatory drugs (NSAIDs) available in France, using data reported through the French pharmacovigilance system. Data (from 2002 to 2006) were analysed for aceclofenac, diclofenac, ketoprofen, meloxicam, naproxen, nimesulide, piroxicam and tenoxicam, focusing on the reported rates of serious adverse drug reactions (ADRs) in the following system organ classes: gastrointestinal, hepatic, cutaneous, renal and cardiovascular. A total of 42 389 serious ADR reports were identified, and 38 506 were included in a case/noncase analysis. Ketoprofen was associated with the highest cumulative reported rate of serious ADRs (0.78 cases per million defined daily doses), followed by diclofenac (0.58), nimesulide (0.52), naproxen...

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Enantioselective enzymatic hydrolysis of racemic drugs by encapsulation in sol-gel magnetic sporopollenin.

Bioprocess and Biosystems Engineering — Tue, 20 Sep 2011 04:00:00 +0100

Authors: Yilmaz E Abstract Candida rugosa lipase was encapsulated within a sol-gel procedure and improved considerably by fluoride-catalyzed hydrolysis of mixtures of octyltriethoxysilane and tetraethoxysilane in the presence of magnetic sporopollenin. The catalytic properties of the immobilized lipases were evaluated into model reactions, i.e., the hydrolysis of p-nitrophenylpalmitate (p-NPP), and the enantioselective hydrolysis of racemic naproxen methyl ester, mandelic acid methyl ester or 2-phenoxypropionic acid methyl ester that were studied in aqueous buffer solution/isooctane reaction system. The encapsulated magnetic sporopollenin (Spo-M-E) was found to give 319 U/g of support with 342% activity yield. It has been observed that the percent activity yields and enantioselect...

Pre-cut dried blood spot (PCDBS): an alternative to dried blood spot (DBS) technique to overcome hematocrit impact.

Rapid Communications in Mass Spectrometry : RCM — Sat, 17 Sep 2011 22:52:23 +0100

Authors: Youhnovski N, Bergeron A, Furtado M, Garofolo F Abstract Quantification of analytes by Dried Blood Spots (DBS) on different paper cards has been extensively reported in the past several years. However, some factors limit the robustness of the precision and accuracy of DBS such as: hematocrit level, blood viscosity, analyte nature, spotting technique and spotting conditions. As such, the paper material used for DBS must meet strict quality control criteria to produce reliable quantification of drugs: uniformity, no chemical leaching and no chromatographic effect. To overcome these variables, especially the hematocrit impact, a modification of the traditional DBS, named Pre-Cut Dried Blood Spot (PCDBS), is presented. In contrast to the classical DBS technique, the new PCDBS ...

Single dose oral analgesics for acute postoperative pain in adults.

Cochrane Database of Systematic Reviews — Fri, 16 Sep 2011 09:32:03 +0100

CONCLUSIONS: There is a wealth of reliable evidence on the analgesic efficacy of single dose oral analgesics. There is also important information on drugs for which there are no data, inadequate data, or where results are unreliable due to susceptibility to publication bias. This should inform choices by professionals and consumers. PMID: 21901726 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

NSAID use associated with increased cardiovascular risk and death, but naproxen appears to be the least harmful

Evidence-Based Medicine — Fri, 16 Sep 2011 04:00:00 +0100

Context Non-steroidal anti-inflammatory drugs (NSAIDs) are a cornerstone of the treatment of mild to moderate pain and are frequently used on a long-term basis for patients with arthritis. In 2004, rofecoxib, a cyclooxygenase-2 (COX-2) inhibitor, was removed from the market because of an increased risk of cardiovascular events associated with the drug.1 Subsequently, concern has grown about the cardiovascular safety of COX-2 inhibitors and traditional non-selective NSAIDs.2 Multiple studies with varying outcomes have not yet answered which, if any, NSAIDs are safe from a cardiovascular standpoint. Methods This was a network meta-analysis that involved large-scale randomised controlled trials comparing any NSAID with other NSAIDs or placebo. Selected studies had at least two arms with at le...

TREXIMET (Sumatriptan Succinate And Naproxen Sodium) Tablet, Film Coated [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 14 Sep 2011 05:00:00 +0100

Updated Date: Sep 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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RX ACT ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet [H E B]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial

International Endodontic Journal — Thu, 08 Sep 2011 04:00:00 +0100

Conclusion A single oral dose of Naproxen, Novafen and Tramadol taken immediately after treatment reduced postoperative pain following pulpectomy and root canal preparation of teeth with irreversible pulpitis. (Source: International Endodontic Journal)

Ibuprofen may ‘raise miscarriage risk’

NHS News Feed — Wed, 07 Sep 2011 10:36:00 +0100

Conclusion This is a large, well-conducted study, the findings of which have been replicated in other studies and its conclusions are likely to be reliable. To explore whether women had taken NSAIDs during pregnancy, the researchers used accurate information from prescriptions rather than asking women to recall what drugs they might have used. Formal medical diagnosis of miscarriage was also used in the analysis rather than relying on patients’ recall. The researchers also adjusted their results for a large number of confounders that might affect the risk of miscarriage. However, as the authors note, the study also had some limitations. It is possible (although probably unlikely), that some women used over-the-counter NSAIDs rather than prescription drugs and these women would not have b...

Anti-Inflammatory Drugs Taken In Early Pregnancy More Than Double Risk Of Miscarriage

Health News from Medical News Today — Wed, 07 Sep 2011 09:00:00 +0100

The risk of miscarriage is 2.4 times greater for women who took any type and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy, according to a University of Montreal study in CMAJ (Canadian Medical Association Journal). Nonaspirin NSAIDs are a class of drugs that include naproxen, ibuprofen, diclofenac, and celecoxib, and are one of the most common medications used during pregnancy. However, there are concerns about use of these drugs in pregnancy, although studies on the risks have been inconsistent... (Source: Health News from Medical News Today)

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I-test: a 34-year-old female with hip pain and remote trauma

British Journal of Sports Medicine — Wed, 07 Sep 2011 04:00:00 +0100

Case A 34-year-old former national gymnast presented to the regional Sports Medicine Centre with a chronic history of intermittent right low back pain, quiescent after physiotherapy. During the appointment, she revealed an ongoing history of right hip discomfort, with clicking and popping, worse during cycling. She had a cycling accident a month earlier, falling onto her right side, with extensive bruising on her right thigh laterally still present during the appointment. She denied any sensory changes and had self-medicated with Naprosyn. On examination, no pelvic tilt or limb length discrepancy was seen. She had mild soft tissue swelling over the lateral aspect of the right hip joint but no bruising. Lumbar spine range of motion was good, with no slump or pain on straight leg raises and ...

Bromination of selected pharmaceuticals in water matrices.

Chemosphere — Wed, 07 Sep 2011 04:00:00 +0100

Authors: Benitez FJ, Acero JL, Real FJ, Roldan G, Casas F Abstract The bromination of five selected pharmaceuticals (metoprolol, naproxen, amoxicillin, phenacetin, and hydrochlorothiazide) was studied with these compounds individually dissolved in ultra-pure water. The apparent rate constants for the bromination reaction were determined as a function of the pH, obtaining the sequence amoxicillin>naproxen≫hydrochlorothiazide≈phenacetin≈metoprolol. A kinetic mechanism specifying the dissociation reactions and the species formed for each compound according to its pK(a) value and the pH allowed the intrinsic rate constants to be determined for each elementary reaction. There was fairly good agreement between the experimental and calculated values of the apparent rate constants...

Common painkillers tied to miscarriage risk

Reuters: Health — Tue, 06 Sep 2011 16:26:25 +0100

NEW YORK (Reuters Health) - Women who use common painkillers like ibuprofen and naproxen early in pregnancy may have an increased risk of miscarriage, a study published Tuesday suggests. (Source: Reuters: Health)

Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion.

cmaj — Tue, 06 Sep 2011 04:00:00 +0100

Authors: Nakhai-Pour HR, Broy P, Sheehy O, Bérard A Abstract BACKGROUND:The association between the use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy and the risk of spontaneous abortion remains unclear because of inconsistent research results and the lack of evidence for an effect due to specific types or dosages of nonaspirin NSAIDs. We aimed to quantify the association between having a spontaneous abortion and types and dosages of nonaspirin NSAIDs in a cohort of pregnant women. METHODS:Using a nested case-control design, we obtained data from the Quebec Pregnancy Registry for 4705 women who had a spontaneous abortion. For each instance, we randomly selected 10 controls from the remaining women in the registry who were matched by index date (date ...

Trace analysis of acidic pharmaceutical residues in waters with isotope dilution gas chromatography-mass spectrometry via methylation derivatization.

Talanta — Sun, 04 Sep 2011 03:41:11 +0100

The objective of this study is to develop a sensitive and reliable method for the determination of acidic pharmaceutical residues in water samples by GC-MS with better resolution by using methylation derivatization and isotope dilution techniques. TMSDM, a mild reagent, was used as the derivatization reagent coupling with the isotope dilution technique, for the first time, to improve the precision and accuracy of the analytical method to determine the pharmaceutical residues in water. The MDLs for the five acidic organic compounds: ibuprofen, gemfibrozil, naproxen, ketoprofen and diclofenac were from 0.7 to 1.1ng/L, with recoveries ranging from 93 to 110%. Alternative to the HPLC-MS/MS method, the developed GC-MS protocols provides an additional option for the analysis of acidic pharmaceut...

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SMART SENSE NAPROXEN SODIUM (Naproxen Sodium) Tablet, Film Coated [Kmart Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 01 Sep 2011 05:00:00 +0100

Updated Date: Sep 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

F112 A STUDY TO DETERMINE ABILITY OF fMRI TO DETECT THE EFFECT OF NAPROXEN ON OSTEOARTHRITIS RELATED PAIN

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

F645 a two period four treatment crossover trial of ph-797804 alone or with naproxen in subjects with painful knee osteoarthritis

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

S166 effects of naproxen on ongoing pain secondary to hand osteoarthritis: a continuous arterial spin labelling study

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine

Surgery — Mon, 29 Aug 2011 22:07:56 +0100

Conclusion: A high-fat diet impairs tissue perfusion in ischemic myocardium of naproxen-treated swine by shifting the prostanoid balance to favor production of thromboxane over prostacyclin. Dietary modification may improve myocardial blood flow and alter the safety profile in chronically ischemic cardiac patients taking naproxen. (Source: Surgery)

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Sumatriptan-Naproxen Migraine Efficacy in Allodynic Patients: Early Intervention.

Headache — Sun, 28 Aug 2011 23:00:00 +0100

Conclusions.- In this open-label study, allodynic patients reported that their migraine attacks responded well and they achieved a high degree of satisfaction following treatment with a fixed-dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg administered in a very early treatment paradigm. PMID: 21883200 [PubMed - as supplied by publisher] (Source: Headache)

Diclofenac/naproxen/piroxicam: Diaphragm disease in an elderly patient: case report

Reactions — Sat, 27 Aug 2011 15:26:04 +0100

(Source: Reactions)

ALEVE (Naproxen Sodium) Capsule, Liquid Filled [Bayer HealthCare LLC, Consumer Care]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 26 Aug 2011 05:00:00 +0100

Updated Date: Aug 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Atmospheric identification of active ingredients in over-the-counter pharmaceuticals and drugs of abuse by atmospheric pressure glow discharge mass spectrometry (APGD-MS).

Rapid Communications in Mass Spectrometry : RCM — Wed, 24 Aug 2011 04:45:01 +0100

Authors: Brewer TM, Verkouteren JR Atmospheric pressure glow discharge mass spectrometry was used to characterize the active ingredients in pharmaceutical over-the-counter (OTC) drug formulations (Tylenol Allergy, Alka-Seltzer Plus Nighttime, Sudafed, Aleve and Mucinex DM) and drugs of abuse (crack cocaine, methamphetamine, MDMA (ecstasy) and hydrocodone). Material was desorbed and directly ionized under atmospheric conditions by allowing the substance to come in direct contact with the plasma followed by mass spectrometric detection. With this technique, controlled substances and OTC medications were readily distinguished from one another. Characteristic mass spectra were identified for the active ingredients in the OTC and drugs of abuse. Importantly, all drug compounds studied here,...

Watchdog Group Asks For Black Box Warning for PPIs

About Heartburn / Acid Reflux — Mon, 22 Aug 2011 23:00:00 +0100

The watchdog group Public Citizen, in a petition filed on Aug 23rd, 2011, is asking the FDA to implement a black box warning for proton pump inhibitors (PPIs). This is in light of various studies that have shown several side effects, and the potential for patients to become dependent on these drugs. "These drugs are being prescribed far too commonly to people who shouldn't be taking them," said Dr. Sidney Wolfe, director of Public Citizen's Health Research Group. "As a result, millions of people are needlessly setting themselves up to become dependent on PPIs while exposing themselves to the serious risks associated with long-term therapy." Some of the risks of using PPIs cited in the petition can include: wrist, hip, and spine fractures can lead to some infections, such as pneum...

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HEALTHY ACCENTS ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet [DZA Brands LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 17 Aug 2011 05:00:00 +0100

Updated Date: Aug 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Coamorphous Drug Systems: Enhanced Physical Stability and Dissolution Rate of Indomethacin and Naproxen

Molecular Pharmaceutics — Mon, 15 Aug 2011 04:00:52 +0100

Molecular PharmaceuticsDOI: 10.1021/mp2002973 (Source: Molecular Pharmaceutics)

THERAPROXEN-90 (Naproxen, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

THERAPROXEN-500 (Naproxen, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

VIMOVO (Naproxen And Esomeprazole Magnesium) Tablet, Delayed Release [STAT RX USA LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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THERAPROXEN (Naproxen, .Gamma.-Aminobutyric Acid) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TREPOXEN-250 (Naproxen,Histidine) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SMART SENSE NAPROXEN SODIUM (Naproxen Sodium) Capsule, Liquid Filled [Kmart Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EQUALINE ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet, Film Coated [Supervalu Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 02 Aug 2011 05:00:00 +0100

Updated Date: Aug 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Capillary electrophoresis determination of nonsteroidal anti‐inflammatory drugs in wastewater using hollow fiber liquid‐phase microextraction

Electrophoresis — Sun, 31 Jul 2011 23:00:00 +0100

AbstractThe presence of pharmaceuticals in the environment due to growing worldwide consumption has become an important problem that requires analytical solutions. This paper describes a CE determination for several nonsteroidal anti‐inflammatory drugs (ibuprofen, naproxen, ketoprofen, diclofenac, ketorolac, aceclofenac and salicylic acid) in environmental waters using hollow fiber membrane liquid‐phase microextraction. The extraction was carried out using a polypropylene membrane supporting dihexyl ether and the electrophoretic separation was performed in acetate buffer (30 mM, pH 4) using ACN as the organic modifier. Detection limits between 0.25 and 0.86 ng/mL were obtained, respectively. The method could be applied to the direct determination of the seven anti‐inflammatories ...

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Pharmacokinetics and Effects of Alkalization During Oral and Intravenous Administration of Naproxen in Horses

Journal of Equine Veterinary Science — Sat, 30 Jul 2011 03:23:19 +0100

Abstract: The use of suitable therapeutic protocols is particularly important when extra-label drugs are used or when physiological parameters are modified, as in the case of the administration of alkaline substances to racehorses. The pharmacokinetics of naproxen (NAP), after both intravenous (iv) and oral administration of 10 mg/kg body weight (BW), was investigated in horses under normal metabolic conditions and in horses whose conditions were modified by the iv administration of 250 mg/kg BW of sodium bicarbonate (NaHCO3). The hypothesis that blood and consequent urinary alkalization could modify NAP pharmacokinetics was evaluated. Drug quantification was performed on serum and urine using High Performance Liquid Chromatography (HPLC) with ultraviolet-visible detection. Results were al...

Long‐Term Evaluation of Sumatriptan and Naproxen Sodium for the Acute Treatment of Migraine in Adolescents

Headache: The Journal of Head and Face Pain — Wed, 27 Jul 2011 23:00:00 +0100

Conclusion.— In adolescent migraineurs, after up to 12 months and over 12,000 exposures to sumatriptan/naproxen sodium, there were no new or clinically significant findings in the safety parameters, including the frequency and nature of adverse events, as compared to the individual components or to the adverse event profile in adults. In addition, sumatriptan/naproxen sodium provided freedom from pain over time, improvements in quality of life and medication satisfaction. (Source: Headache: The Journal of Head and Face Pain)

Long-Term Evaluation of Sumatriptan and Naproxen Sodium for the Acute Treatment of Migraine in Adolescents.

Headache — Wed, 27 Jul 2011 23:00:00 +0100

Conclusion.- In adolescent migraineurs, after up to 12 months and over 12,000 exposures to sumatriptan/naproxen sodium, there were no new or clinically significant findings in the safety parameters, including the frequency and nature of adverse events, as compared to the individual components or to the adverse event profile in adults. In addition, sumatriptan/naproxen sodium provided freedom from pain over time, improvements in quality of life and medication satisfaction. PMID: 21797863 [PubMed - as supplied by publisher] (Source: Headache)

Compounds against inflammation and oxidative insult as potential agents for neurodegenerative disorders

Medicinal Chemistry Research — Wed, 27 Jul 2011 15:50:39 +0100

Abstract Amides of proline, a feature encountered in nootropics, via the carboxylic group of ibuprofen, indomethacin, ketoprofen and naproxen were prepared. Proline carboxylic group was amidated or esterified with potential antioxidant or neuroprotective compounds. Proline was replaced by 4-hydroxyproline, 2-pipecolic acid or omitted, for investigating the contribution of structure to activity. Anti-inflammatory activity was determined, and selected compounds were examined for anti-dyslipidemic action, protection against brain ischaemia/reperfusion and brain penetration. Graphical abstract Amides of proline and related structures with NSAIDs were synthesized. They were amidated or esterified with antioxidant or neuroprotective compounds. Activity against...

RX ACT ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet, Film Coated [H E B]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 27 Jul 2011 05:00:00 +0100

Updated Date: Jul 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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DG HEALTH ALL DAY PAIN RELIEF (Naproxen Sodium) Tablet, Film Coated [Dolgencorp Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 22 Jul 2011 05:00:00 +0100

Updated Date: Jul 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Longitudinal Numbers-Needed-To-Treat (NNT) For Achieving Various Levels of Analgesic Response and Improvement with Etoricoxib, Naproxen, and Placebo in Ankylosing Spondylitis

BMC Musculoskeletal Disorders — Sun, 17 Jul 2011 23:00:00 +0100

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An in‐line SPE strategy to enhance sensitivity in CE for the determination of pharmaceutical compounds in river water samples

Electrophoresis — Sun, 17 Jul 2011 23:00:00 +0100

In this study, the suitability of solid‐phase extraction (SPE) coupled in‐line to CE with UV–Vis detection was evaluated for the preconcentration and separation of diluted solutions of five pharmaceuticals compounds: benzafibrate, piroxicam, diclofenac sodium, naproxen and clofibric acid. An SPE analyte concentrator containing Oasis® HLB sorbent was constructed without frits and placed near the inlet end of the separation capillary. Different parameters such as sample pH, composition and volume of the elution plug and sample loading time were studied in order to obtain the maximum preconcentration factors. The LODs reached for standard samples were in the range 0.06–0.5 ng/mL with good reproducibility, and the developed strategy provides sensitivity enhancement factors around 14...

NAPROSYN (Naproxen) Tablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 15 Jul 2011 05:00:00 +0100

Updated Date: Jul 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

COXIBs, CINODs and H2S-Releasing NSAIDs: Current Perspectives in the Development of Safer Non Steroidal Anti-Inflammatory Drugs.

Current Medicinal Chemistry — Wed, 13 Jul 2011 23:00:00 +0100

Authors: Fiorucci S, Distrutti E Traditional nonsteroidal anti-inflammatory drugs, tNSAIDs, are effective medication for prevention of ischemic events and treatment of pain, fever and inflammation. However their use associates with a significant risk to develop gastrointestinal and cardiovascular complications. Low doses of acetyl salicylic acid (ASA) and effective doses of tNSAIDs associate with a 2-6 fold increase in the risk of gastrointestinal bleeding. ASA and tNSAIDs inhibit cyclooxygenases (COXs). The COX exists at least in two isoforms, COX-1 and COX-2. Selective inhibitors of COX-2, the coxibs, spares the gastrointestinal tract while exert anti-inflammatory and analgesic effects. However, coxibs increase the risk of thrombo-embolic events. Nitric oxide (NO) and hydrogen sulfid...

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NAPROXEN SODIUMtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 13 Jul 2011 05:00:00 +0100

Updated Date: Jul 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

VIMOVO (Naproxen And Esomeprazole Magnesium) Tablet, Delayed Release [AstraZeneca LP]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 12 Jul 2011 05:00:00 +0100

Updated Date: Jul 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

Gastroenterology — Mon, 11 Jul 2011 04:00:00 +0100

Conclusions: PPIs exacerbate NSAID-induced intestinal damage at least in part because of significant shifts in enteric microbial populations. Prevention or reversal of this dysbiosis may be a viable option for reducing the incidence and severity of NSAID enteropathy. (Source: Gastroenterology)

NAPROXEN Tablet [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 07 Jul 2011 05:00:00 +0100

Updated Date: Jul 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))