MedWorm: Allegra

fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's Allegra

MedicineNet Allergies General — Wed, 01 Feb 2012 07:00:00 +0100

Title: fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's AllegraCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/1/2012 (Source: MedicineNet Allergies General)

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The Editors’ Choice

Journal of Allergy and Clinical Immunology — Wed, 01 Feb 2012 05:00:00 +0100

Allergic rhinitis or hay fever is a common disease caused by environmental allergens, such as pollens and animal dander, in allergic persons. Characteristic symptoms include runny nose, nasal itching, sneezing, and congestion. Antihistamines that block the first of 4 different receptors, molecules that mediate the effects of histamine released during allergies, are available over the counter and by prescription. These antihistamines are effective in treating allergic rhinitis–associated itching, runny nose, and sneezing but are not very effective against nasal congestion, often the most bothersome symptom. A number of decongestants are available either alone or in combination with these antihistamines, but they are not completely effective in treating nasal congestion either, and they of...

Association of Obesity With DNA Mismatch Repair Status and Clinical Outcome in Patients With Stage II or III Colon Carcinoma Participating in NCCTG and NSABP Adjuvant Chemotherapy Trials [Gastrointestinal Cancer]

Journal of Clinical Oncology — Fri, 27 Jan 2012 05:00:00 +0100

Conclusion Colon cancers from obese patients are less likely to show dMMR, suggesting obesity-related differences in the pathogenesis of colon cancer. Although obesity was independently associated with adverse outcome, the favorable prognostic impact of dMMR was maintained among obese patients. (Source: Journal of Clinical Oncology)

Effects of Bepotastine and Fexofenadine on Histamine-Induced Flare, Wheal and Itch

International Archives of Allergy and Immunology — Wed, 25 Jan 2012 23:00:00 +0100

Int Arch Allergy Immunol 2012;158:191–195 (DOI:10.1159/000330663) (Source: International Archives of Allergy and Immunology)

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Malawi: Peace Corps Volunteer Lights Up Health Center in Malawi

AllAfrica News: Health and Medicine — Tue, 24 Jan 2012 16:16:05 +0100

State Department (Washington, DC)-Peace Corps volunteer Allegra Panetto of Haworth, New Jersey, is working with a health center in eastern Malawi to power electricity in several of the center's rooms using solar energy. (Source: AllAfrica News: Health and Medicine)

Implication of the VGF-derived peptide TLQP-21 in mouse acute and chronic stress responses.

Behavioural Brain Research — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Razzoli M, Bo E, Pascucci T, Pavone F, D'Amato FR, Cero C, Sanghez V, Dadomo H, Palanza P, Parmigiani S, Ceresini G, Puglisi-Allegra S, Porta M, Panzica GC, Moles A, Possenti R, Bartolomucci A Abstract The impact of stress is widely recognized in the etiology of multiple disorders. In particular, psychological stress may increase the risk of cardiovascular, metabolic, immune, and mood disorders. Several genes are considered potential candidates to account for the deleterious consequences of stress and recent data point to role of Vgf. VGF mRNA is abundantly expressed in the hypothalamus, where it has been involved in metabolism and energy homeostasis; more recently a link between VGF-derived peptides and mood disorders has been highlighted. The following experiments were p...

Roles of Histamine in Exercise-Induced Fatigue: Favouring Endurance and Protecting against Exhaustion.

Biological and Pharmaceutical Bulletin — Fri, 13 Jan 2012 09:48:02 +0100

Authors: Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T Abstract Exercise necessitates a large supply of O(2) and nutrients and rapid removal of CO(2) and waste products. Histamine is a regulator of the microcirculation (which performs these exchanges), suggesting a possible involvement of histamine in exercise. Histamine is released from either mast cells or non-mast cells. In the latter, histamine is newly formed via the induction of histidine decarboxylase (HDC) in response to an appropriate stimulus, and it is released without being stored. Here, in mice, we examined the role of histamine or HDC induction in exercise. Prolonged walking (PW) (in a cylindrical cage turned electrically) increased HDC mRNA and HDC activity in quadriceps femoris muscles...

H3 receptor antagonist may ease allergic rhinitis

Modern Medicine — Wed, 04 Jan 2012 05:00:00 +0100

NEW YORK (Reuters Health) - The effect of fexofenadine against allergen-induced nasal symptoms was enhanced with the addition of an experimental H3 receptor antagonist, in a study reported recently. (Source: Modern Medicine)

H1‐antihistamines and urticaria: how can we predict the best drug for our patient?

Clinical and Experimental Allergy — Sun, 01 Jan 2012 05:00:00 +0100

AbstractUrticaria, and especially chronic spontaneous urticaria, is a difficult condition to treat. Consequently, clinicians need to use the best H1‐antihistamines currently available and the pharmaceutical industry need to keep developing H1‐antihistamines that are more effective than the ones we have today. To do this we need to be able to compare the clinical efficacy of both established and new drugs. Obviously, the ideal way to do this is to use head to head studies in CSU. However, such studies are extremely expensive and, in the case of novel molecules, have ethical and logistical problems. Consequently, we need to have predictive models. While determination of Ki, an indicator of the in vitro potency of an H1‐antihistamine, may help in the initial selection of candidate molec...

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The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms

Journal of Allergy and Clinical Immunology — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: In combination with fexofenadine, single doses of PF-03654746 caused a reduction in allergen-induced nasal symptoms. H3 receptor antagonism might be a novel therapeutic strategy to further explore in patients with allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)

Effect of bilastine upon the ocular symptoms of allergic rhinoconjunctivitis.

Journal of Investigational Allergology and Clinical Immunology — Sat, 24 Dec 2011 18:00:02 +0100

Authors: Bartra J, Mullol J, Montoro J, Jáuregui I, del Cuvillos A, Dávila I, Ferrer M, Sastre J, Valero A Abstract Ocular symptoms often accompany allergic rhinitis and can be as or even more bothersome for the patient than the actual nasal symptoms. Ocular manifestations of allergic rhinoconjunctivitis may result from both direct allergen-mediated mast cell stimulation on the surface of the eye and naso-ocular reflexes--histamine being one of the mediators of symptoms onset. An H1 antihistamine would be the first line treatment for allergic conjunctivitis. Since allergic conjunctivitis is always (or almost always) accompanied by nasal symptoms, a second-generation H1 antihistamine administered via oral route is the drug of choice for jointly managing both the nasal and the ocul...

Bilastine and quality of life.

Journal of Investigational Allergology and Clinical Immunology — Sat, 24 Dec 2011 18:00:02 +0100

Authors: Jáuregui I, Bartra J, del Cuvillo A, Dávila I, Ferrer M, Montoro J, Mullol J, Sastre J, Valero A Abstract The evaluation of quality of life (QoL) and its modification through therapeutic interventions has become a prioritary concern in recent years and a requirement on the part of regulatory agencies for the authorization of new drugs. In clinical studies of allergic disorders, particularly allergic rhinitis and urticaria, different types of generic questionnaires have been used - especially disease specific instruments such as the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) or skin disease specific tools such as the Dermatology Life Quality Index (DLQI). Throughout its clinical development, bilastine has been shown to be more effective than placebo and at l...

Effect of bilastine upon nasal obstruction.

Journal of Investigational Allergology and Clinical Immunology — Sat, 24 Dec 2011 18:00:02 +0100

Authors: Dávila I, Sastre J, Mullol J, Montoro J, Jáuregui I, Ferrer M, del Cuvillo A, Bartra J, Valero A Abstract H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these drugs have been considered effective in controlling sneezing, rhinorrhea and itching, though they have not been regarded as particularly effective in application to nasal obstruction. The most recent studies, involving second-generation H1 antihistamines (desloratadine, fexofenadine, levocetirizine, rupatadine), have shown these drugs to offer effects upon nasal obstruction significantly superior to those of placebo. The present review examines the effect of bilastine, a new, potent and highly specific H1 antihistamine without sedative effects or cardiac...

MEMBERS MARK FEXOFENADINE (Fexofenadine Hydrochloride) Tablet, Film Coated [Sam'S West Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 23 Dec 2011 05:00:00 +0100

Updated Date: Dec 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ALLERGY RELIEF (Fexofenadine Hcl) Tablet, Film Coated [H E B]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 19 Dec 2011 05:00:00 +0100

Updated Date: Dec 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Severe dermatologic adverse reactions after exposure to lenalidomide in multiple myeloma patients with a positive HLA-DRB11501 and HLA-DQB10602.

Acta Oncologica — Mon, 12 Dec 2011 05:00:00 +0100

Authors: Penna G, Allegra A, Romeo G, Alonci A, Cannavò A, Russo S, D'Angelo A, Petrungaro A, Musolino C PMID: 22150117 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

David Cameron's science lesson

Guardian Unlimited Science — Wed, 07 Dec 2011 15:36:20 +0100

The prime minister is learning fast: science matters to the UK economy but science's economics do not necessarily mean jobsBefore entering politics, Margaret Thatcher was an Oxford-trained chemist who worked for a time as a scientist researching how to inject air into ice-cream, so creating the soft-scoop process which, it would be fun to imagine, allowed the introduction of Mr Whippy.Germany's chancellor, Angela Merkel, worked for a time on quantum chemistry in the late 70s – looking at the decay of hydrocarbon molecules which, it would not be fun to imagine, is now informing her euro policy.David Cameron has no such pedigree and admitted as much in one of the seminars running up to Monday's announcement of a multimillion-pound package of measures to support the UK's life sciences indus...

KIRKLAND SIGNATURE ALLER FEX (Fexofenadine Hydrochloride) Tablet, Film Coated [Costco Wholesale Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 05 Dec 2011 05:00:00 +0100

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets

Chemistry Central Journal — Sat, 03 Dec 2011 05:00:00 +0100

A simple reversed phase high performance liquid chromatographic method with diode array detector (HPLC-DAD) has been developed and subsequently validated for the determination of fexofenadine hydrochloride (FEX) and its related compounds; keto fexofenadine (Impurity A), meta isomer of fexofenadine (Impurity B), methyl ester of fexofenadine (Impurity C) in addition to the methyl ester of ketofexofenadine (Impurity D). The separation was based on the use of a Hypersil BDS C-18 analytical column (250 x 4.6 mm, i.d., 5 Micro-m). The mobile phase consisted of a mixture of phosphate buffer containing 0.1 gm% of 1-octane sulphonic acid sodium salt monohydrate and 1% (v/v) of triethylamine, pH 2.7 and methanol (60:40, v/v). The separation was carried out at ambient temperature with a flow rate of ...

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Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers

Archives of Dermatological Research — Wed, 30 Nov 2011 18:42:23 +0100

Abstract Since most first-generation antihistamines have undesirable sedative effects on the central nervous systems (CNS), newer (second-generation) antihistamines have been developed to improve patients’ quality of life. However, there are few reports that directly compare the antihistaminic efficacy and impairment of psychomotor functions. We designed a double-blind, placebo controlled, crossover study to concurrently compare the clinical effectiveness of promethazine, a first-generation antihistamine, and fexofenadine and olopatadine, second-generation antihistamines, by measuring their potency as peripheral inhibitors of histamine-induced wheal and flare. Further, we investigated their sedative effects on the CNS using a battery of psychomotor tests. When single the...

CARE ONE ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [American Sales Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

WAL FEX ALLERGY (Fexofenadine Hydrochloride) Tablet, Film Coated [Walgreen Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXO FENADINE (Fexofenadine Hydrochloride) Tablet, Film Coated [Kroger Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 30 Nov 2011 05:00:00 +0100

Updated Date: Nov 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

European Journal of Clinical Pharmacology — Mon, 28 Nov 2011 16:59:47 +0100

Conclusions Grapefruit juice decreases exposure of aliskiren partially via inhibition of intestinal OATP1A2. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-12DOI 10.1007/s00228-011-1167-4Authors Sam Rebello, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USASally Zhao, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USASam Hariry, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, East Hanover, NJ 07936-1080, USAMarion Dahlke, Translational Sciences, Novartis Institute for Biomedical Research, One Health Plaza, Bldg 438-3410, Eas...

CHILDRENS ALLEGRA ALLERGY (Fexofenadine Hydrochloride) Suspension [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Nov 2011 05:00:00 +0100

Updated Date: Nov 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GOOD SENSE ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [L Perrigo Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 23 Nov 2011 05:00:00 +0100

Updated Date: Nov 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.

Rapid Communications in Mass Spectrometry : RCM — Wed, 23 Nov 2011 03:37:10 +0100

Authors: Eikel D, Vavrek M, Smith S, Bason C, Yeh S, Korfmacher WA, Henion JD Abstract Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel surface profiling technique that combines micro-liquid extraction from a solid surface with nano-electrospray mass spectrometry. One potential application is the examination of the distribution of drugs and their metabolites by analyzing ex vivo tissue sections, an area where quantitative whole body autoradiography (QWBA) is traditionally employed. However, QWBA relies on the use of radiolabeled drugs and is limited to total radioactivity measured whereas LESA-MS can provide drug- and metabolite-specific distribution information. Here, we evaluate LESA-MS, examining the distribution and biotransformation of unlabeled terfen...

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Western Family Foods Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [Meijer Distribution Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Safeway]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

EQUALINE ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [Supervalu Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [Rite Aid Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GOOD NEIGHBOR PHARMACY ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [Amerisource Bergen]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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EQUATE ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [Wal-Mart Stores Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

LEADER ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DG HEALTH ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [Dolgencorp, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TOPCARE FEXOFENADINE HYDROCHLORIDE (Fexofenadine Hydrochloride) Tablet, Film Coated [Topco Associates LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

UP AND UP ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [Target Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Perrigo New York Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Shining moment for maths

Guardian Unlimited Science — Wed, 16 Nov 2011 23:24:58 +0100

Warm words for humanities and languages, but it is sciences that the state want to push in schoolsAs Tony Blair was hosting drinks parties with Britain's cultural elite to the soundtrack of Things Can Only Get Better, one member of the band was toiling away to become a physicist.Brian Cox had joined D:Ream while he was at Manchester University. But as he did lab work by day, he also turned in crepuscular shifts in many other arenas. Eventually, a year after they disbanded in 1997, Cox was awarded his PhD in high energy particle physics. Cox, now the Hadron Collider of TV personalities, played the keyboards for Cool Britannia.His relationship with the current education secretary took a momentary hit after journalist Sarah Vine, married to Michael Gove, suggested Cox's "intergalactic" ego ma...

SMART SENSE ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [Kmart Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 15 Nov 2011 05:00:00 +0100

Updated Date: Nov 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXO FENADINE (Fexofenadine Hydrochloride) Tablet, Film Coated [HyVee Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 15 Nov 2011 05:00:00 +0100

Updated Date: Nov 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SUNMARK FEXOFENADINE HYDROCHLORIDE (Fexofenadine Hydrochloride) Tablet, Film Coated [McKesson]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 15 Nov 2011 05:00:00 +0100

Updated Date: Nov 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Combination Therapy for Renal Cell Cancer: What Are Possible Options?

Oncology — Sat, 12 Nov 2011 05:00:00 +0100

Authors: Santos N, Wenger JB, Havre P, Liu Y, Dagan R, Imanirad I, Ivey AM, Zlotecki RA, Algood CB, Gilbert SM, Allegra CJ, Okunieff P, Vieweg J, Dang NH, Luesch H, Dang LH Abstract Antiangiogenic therapy has shown promise in the treatment of patients with renal cell carcinoma (RCC). Two classes of antiangiogenic drugs, the anti-vascular endothelial growth factor antibody bevacizumab and the tyrosine kinase inhibitors sorafenib, sunitinib and pazopanib, have shown efficacy in patients with RCC and are approved by the US Food and Drug Administration for treatment of this cancer. In practice, the clinical benefit of antiangiogenic drugs in RCC has been heterogeneous, and in patients who do respond, benefits are modest and/or short-lived. To improve efficacy, combination targeted ther...

Involvement of T2677T multidrug resistance gene polymorphism in Interleukin 22 plasma concentration in B-chronic lymphocytic leukemia patients.

Acta Oncologica — Wed, 09 Nov 2011 05:00:00 +0100

Authors: Musolino C, Allegra A, Ferraro M, Aguennouz M, Russo S, Alonci A, Saitta S, Gangemi S PMID: 22070651 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

ALLERGY RELIEF (Fexofenadine Hydrochloride) Tablet, Film Coated [H E B]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Nov 2011 05:00:00 +0100

Updated Date: Nov 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NSAID-sensitive antihistamine-induced urticaria/angioedema.

Journal of Investigational Allergology and Clinical Immunology — Mon, 07 Nov 2011 15:00:03 +0100

We describe the first case of a possible new subset of antihistamine urticaria, and suggest calling this NSAID-sensitive antihistamine-induced urticaria/angioedema. PMID: 21995184 [PubMed - indexed for MEDLINE] (Source: Journal of Investigational Allergology and Clinical Immunology)

Real-life prospective study on asthma control in Italy: Cross-sectional phase results

Respiratory Medicine — Mon, 31 Oct 2011 04:00:00 +0100

Summary: Objectives: To estimate the prevalence of partly controlled and uncontrolled asthmatic patients, to evaluate quality of life and healthcare resource consumption.Methods: Cross-sectional phase followed by a 12-month prospective phase. Asthma Control Test and the EQ-5D were used.Results: 2853 adult patients recruited in 56 Hospital Respiratory Units in Italy were evaluated: 64.4% had controlled asthma, 15.8% partly controlled asthma and 19.8% were uncontrolled. The mean (SD) EQ-5D score was 0.86 (0.17) in controlled, 0.75 (0.20) in partly controlled and 0.69 (0.23) in uncontrolled patients (p (Source: Respiratory Medicine)

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FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [UDL Laboratories Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 28 Oct 2011 05:00:00 +0100

Updated Date: Oct 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Identification of the Schistosoma mansoni Molecular Target for the Antimalarial Drug Artemether

Journal of Chemical Information and Modeling — Fri, 28 Oct 2011 04:27:49 +0100

Journal of Chemical Information and ModelingDOI: 10.1021/ci2001764 (Source: Journal of Chemical Information and Modeling)

Alternative End Points to Evaluate a Therapeutic Strategy in Advanced Colorectal Cancer: Evaluation of Progression-Free Survival, Duration of Disease Control, and Time to Failure of Strategy--An Aide et Recherche en Cancerologie Digestive Group Study [STATISTICS IN ONCOLOGY]

Journal of Clinical Oncology — Fri, 28 Oct 2011 04:00:00 +0100

Conclusion DDC and TFS roughly achieved the same results. Both are acceptable new end points to evaluate a therapeutic strategy in ACRC. Although TFS achieved a pragmatic evaluation of a multiline strategy, DDC captured the effect of a specific sequence in a therapeutic strategy. (Source: Journal of Clinical Oncology)

Ten Simple Rules for Developing a Short Bioinformatics Training Course

PLoS Computational Biology — Thu, 27 Oct 2011 04:00:00 +0100

by Allegra Via, Javier De Las Rivas, Teresa K. Attwood, David Landsman, Michelle D. Brazas, Jack A. M. Leunissen, Anna Tramontano, Maria Victoria Schneider (Source: PLoS Computational Biology)

Deficits in Dopamine D2 Receptors and Presynaptic Dopamine in Heroin Dependence: Commonalities and Differences with Other Types of Addiction

Biological Psychiatry — Thu, 20 Oct 2011 04:00:00 +0100

Conclusions: These findings show that heroin addiction, like addiction to other drugs of abuse, is associated with low D2/3 receptor binding and low presynaptic dopamine. However, neither of these outcome measures was associated with the choice to self-administer heroin. (Source: Biological Psychiatry)

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GOOD SENSE ALLER EASE (Fexofenadine Hcl) Tablet, Film Coated [L Perrigo Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Oct 2011 05:00:00 +0100

Updated Date: Oct 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Syntheses and Structural Characterizations of Anionic Borane-Capped Ammonia Borane Oligomers: Evidence for Ammonia Borane H2 Release via a Base-Promoted Anionic Dehydropolymerization Mechanism

Journal of the American Chemical Society — Fri, 30 Sep 2011 15:15:37 +0100

Journal of the American Chemical SocietyDOI: 10.1021/ja207971h (Source: Journal of the American Chemical Society)

Carbamazepine Differentially Affects the Pharmacokinetics of Fexofenadine Enantiomers

British Journal of Clinical Pharmacology — Thu, 29 Sep 2011 05:26:40 +0100

Conclusion: This study indicates that carbamazepine may alter the pharmacokinetics of fexofenadine enantiomers. (Source: British Journal of Clinical Pharmacology)

FEXOFENADINE HCL AND PSEUDOEPHEDRINE HCItablet, Extended Release [Dr.Reddy'S Laboratories Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 29 Sep 2011 05:00:00 +0100

Updated Date: Sep 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Oxaliplatin As Adjuvant Therapy for Colon Cancer: Updated Results of NSABP C-07 Trial, Including Survival and Subset Analyses [Gastrointestinal Cancer]

Journal of Clinical Oncology — Thu, 29 Sep 2011 04:00:00 +0100

Conclusion Overall, the addition of oxaliplatin to FULV has not been proven to extend OS in this trial, but the DFS effect remained strong. Unplanned subset analyses suggest a significant OS effect of oxaliplatin in patients younger than age 70. (Source: Journal of Clinical Oncology)

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Giant Eagle offers free allergy screenings

Drug Topics - Top News — Tue, 27 Sep 2011 04:00:00 +0100

Select Giant Eagle pharmacies partnered with Allegra and US Wellness to offer free allergy testing this fall. The screenings covered the 10 most common allergens. (Source: Drug Topics - Top News)

Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells

Oncogene — Mon, 26 Sep 2011 04:00:00 +0100

Authors: Y Cheli, S Giuliano, N Fenouille, M Allegra, V Hofman, P Hofman, P Bahadoran, J-P Lacour, S Tartare-Deckert, C Bertolotto & R Ballotti (Source: Oncogene)

Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.

European Journal of Pharmaceutical Sciences — Thu, 22 Sep 2011 04:00:00 +0100

Authors: Kataoka M, Yokoyama T, Masaoka Y, Sakuma S, Yamashita S Abstract The purpose of this study was to establish an in vitro system that evaluates the effects of P-glycoprotein (P-gp)-mediated efflux on the oral absorption of P-gp substrates. An in vitro system (dissolution/permeation system, D/P system) was developed that consisted of apical and basal chambers and a Caco-2 cell monolayer mounted between the chambers. Both sides of the monolayer were filled with physiological solution and were stirred at 200rpm. The dissolution in the apical medium and permeation to the basal medium were monitored for 2h after P-gp substrates were applied to the apical side of the system. When erythromycin existed in the apical medium, the permeations of fexofenadine and talinolol were signific...

The impact of language on the expression and assessment of pain in children

Intensive and Critical Care Nursing — Mon, 19 Sep 2011 06:12:19 +0100

Summary: This paper focuses on the importance of language in the expression of pain. Variation in definitions of pain is presented, together with a review of the evidence examining the impact language may have on the way pain is expressed linguistically. The implications for conducting research with children who speak different languages are explored. Strategies such as using non-linguistic methods of communication, additional time required for conducting interviews and the inclusion of research team members from the same ethnic or linguistic background are presented. (Source: Intensive and Critical Care Nursing)

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Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia.

Clinical Biochemistry — Fri, 16 Sep 2011 04:00:00 +0100

CONCLUSIONS: B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL. PMID: 21945028 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)

FEXOFENADINE HYDROCHLORIDEtablet [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Sep 2011 05:00:00 +0100

Updated Date: Sep 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [Winthrop U.S.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Prasco Laboratories]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [TEVA PHARMACEUTICALS USA INC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Dr Reddy's launches OTC drug in the US market

The Economic Times Healthcare and Biotech News — Tue, 30 Aug 2011 16:29:18 +0100

The company's product is a bio equivalent version of Sanofi Aventis' Allegra D24 Hour extended release tablets, it said. (Source: The Economic Times Healthcare and Biotech News)

FEXOFENADINE HYDROCHLORIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 22 Aug 2011 05:00:00 +0100

Updated Date: Aug 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Aminoterminal natriuretic peptides and cardiovascular risk in an Italian male adult cohort

International Journal of Cardiology — Mon, 22 Aug 2011 04:00:00 +0100

Precursors of both atrial and B-type natriuretic peptides (NT-proNPs) are emerging markers of prevalent cardiovascular diseases (CVD) and helpful predictors of outcome in patients with established CVD . They have larger molecular weight, longer half-life, and are easier to measure in plasma. Several prospective studies have shown that NT-proNP levels are sensitive, cost effective tool to add prognostic information above existing clinical characteristics by accurately predicting the outcome in heart failure and ischemic heart disease patients . A part from brain natriuretic peptide (NT-proBNP), currently the peptide of choice in clinical practice, the atrial natriuretic peptide (NT-proANP) and the newly discovered MR-NT-proANP have shown to exert powerful predictive role in CAD patients . T...

HEALTHY ACCENTS ALLER EASE (Fexofenadine Hydrochloride) Tablet, Film Coated [DZA Brands LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 19 Aug 2011 05:00:00 +0100

Updated Date: Aug 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ALLEGRA--D 24 HOUR ALLERGY AND CONGESTION (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 16 Aug 2011 05:00:00 +0100

Updated Date: Aug 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALLEGRA D 12 HOUR ALLERGY AND CONGESTION (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 16 Aug 2011 05:00:00 +0100

Updated Date: Aug 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDE (Fexofenadine Hcl) Tablet, Film Coated [Perrigo New York Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 15 Aug 2011 05:00:00 +0100

Updated Date: Aug 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Nanoparticles in Oncology: The New Theragnostic Molecules

Fri, 12 Aug 2011 15:16:34 +0100

(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))

Development of a novel high-throughput analytical methodology, multiple injection method, for quantitative analysis in drug metabolism and pharmacokinetic studies using liquid chromatography with tandem mass spectrometry.

Biological and Pharmaceutical Bulletin — Thu, 11 Aug 2011 14:00:04 +0100

In this study, we developed a novel methodology, multiple injection method (MIM), for higher-throughput screening of compounds by liquid chromatography-tandem mass spectrometry (LC-MS/MS). MIM involves continuous injections of multiple samples containing a different compound respectively into the column, and then temporarily trapping of analytes at the column head in high-pressure liquid chromatography (HPLC) system. This is followed by elution of all the compounds from the column and detection of them by MS/MS. In this study, fexofenadine, verapamil, risperidone, ondansetron, and imipramine were used as model compounds to investigate the effectiveness of MIM in pharmacokinetic studies. Analytical time of validation samples of these model compounds could be shortened to one third by MIM, c...

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Vectorial Transport of Fexofenadine across Caco-2 Cells: Involvement of Apical Uptake and Basolateral Efflux Transporters

Molecular Pharmaceutics — Fri, 05 Aug 2011 20:21:33 +0100

Molecular PharmaceuticsDOI: 10.1021/mp200026v (Source: Molecular Pharmaceutics)

FEXOFENADINE HYDROCHLORIDE (Fexofenadine) Tablet, Film Coated [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 01 Aug 2011 05:00:00 +0100

Updated Date: Aug 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Hospital Admission Rates for Emergency Department Patients with Transient Ischemic Attack are Higher in the United States than Canada

The Journal of Emergency Medicine — Sun, 31 Jul 2011 23:00:00 +0100

The United States spends a greater proportion of its gross domestic product (GDP) on health care than any other country. One cause for this may be lower physician risk tolerance in the United States due to concern about malpractice litigation. Transient ischemic attack (TIA) is a common emergency department (ED) complaint for which hospitalization is usually of little benefit. Despite numerous publications identifying low-risk patients safe for discharge, there is still concern that a patient may develop a stroke at home, so physicians often admit their TIA patients. No previous published manuscript has compared US admission rates for TIA with those in other countries. We hypothesize that greater concerns about malpractice litigation in the United States results in higher rates of hospital...

ALLEGRA D 12 HOUR ALLERGY AND CONGESTION (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 22 Jul 2011 05:00:00 +0100

Updated Date: Jul 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.

Rapid Communications in Mass Spectrometry : RCM — Wed, 20 Jul 2011 03:15:10 +0100

Authors: Flynn CA, Alnouti Y, Reed GA Drug-drug interactions at transporters present a significant and under-investigated clinical problem. Investigations of specific transporter functions and screening for potential drug-drug interactions, both in vitro and especially in vivo, will require validated experimental probes. Fexofenadine, an approved, well-tolerated drug, is a promising probe for studies of membrane transporter function. Although fexofenadine pharmacokinetics are known to be controlled by transporters, the contributions of individual transporters have not been defined. We have developed a rapid, specific, and sensitive analytical method for quantitation of fexofenadine to support this work. This liquid chromatography/tandem mass spectrometry (LC/MS/MS) method quantifies fe...

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FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 19 Jul 2011 05:00:00 +0100

Updated Date: Jul 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Correction for Silverman et al., Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate [Correction]

Proceedings of the National Academy of Sciences — Mon, 18 Jul 2011 23:00:00 +0100

GENETICS Correction for “Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate,” by Sanford J. Silverman, Allegra A. Petti, Nikolai Slavov, Lance Parsons, Ryan Briehof, Stephan Y. Thiberge, Daniel Zenklusen, Saumil J. Gandhi, Daniel R. Larson, Robert H. Singer, and David Botstein, which appeared in issue 15, April 13, 2010, of Proc Natl Acad Sci USA (107:6946–6951; first published March 24, 2010; 10.1073/pnas.1002422107).The authors note that, on page 6950, right column, line 4 of Growth Conditions, “(8 mg/L)” should instead appear as “(0.8 g/L).” This error does not affect the conclusions of the article. (Source: Proceedings of the National Academy of Sciences)

A diagnostic approach to pruritus.

American Family Physician — Thu, 14 Jul 2011 23:00:00 +0100

Authors: Reamy BV, Bunt CW, Fletcher S Pruritus can be a symptom of a distinct dermatologic condition or of an occult underlying systemic disease. Of the patients referred to a dermatologist for generalized pruritus with no apparent primary cutaneous cause, 14 to 24 percent have a systemic etiology. In the absence of a primary skin lesion, the review of systems should include evaluation for thyroid disorders, lymphoma, kidney and liver diseases, and diabetes mellitus. Findings suggestive of less serious etiologies include younger age, localized symptoms, acute onset, involvement limited to exposed areas, and a clear association with a sick contact or recent travel. Chronic or generalized pruritus, older age, and abnormal physical findings should increase concern for underlying systemic...

FEXOFENADINE HYDROCHLORIDEtablet [Dr. Reddy'S Laboratories Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 12 Jul 2011 05:00:00 +0100

Updated Date: Jul 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

European Journal of Nutrition — Thu, 07 Jul 2011 05:45:16 +0100

Conclusions Our results provide molecular evidence of anti-inflammatory activity of pistachio nut and indicate polymeric proanthocyanidins as the bioactive components. The mechanism may involve the redox-sensitive transcription factor NF-κB. Potential effects associated with pistachio nut consumption are discussed in terms of the proanthocyanidin bioavailability. Content Type Journal ArticlePages 1-11DOI 10.1007/s00394-011-0220-5Authors C. Gentile, Dipartimento STEMBIO, Università di Palermo, Via M. Cipolla 74, 90123 Palermo, ItalyM. Allegra, Dipartimento STEMBIO, Università di Palermo, Via M. Cipolla 74, 90123 Palermo, ItalyF. Angileri, Dipartimento STEMBIO, Università di Palermo, Via M. Cipolla 74, 90123 Palermo, ItalyA. M. Pintaudi, Dipartimento STEMBIO, Univ...

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ALLEGRA--D 24 HOUR ALLERGY AND CONGESTION (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 30 Jun 2011 05:00:00 +0100

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALLEGRA D 12 HOUR ALLERGY AND CONGESTION (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 30 Jun 2011 05:00:00 +0100

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CHILDRENS ALLEGRA ALLERGY (Fexofenadine Hydrochloride) Tablet, Orally Disintegrating [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 30 Jun 2011 05:00:00 +0100

Updated Date: Jun 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CHILDRENS ALLEGRA ALLERGY (Fexofenadine Hydrochloride) Tablet, Film Coated ALLEGRA ALLERGY (Fexofenadine Hydrochloride) Tablet, Film Coated [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 28 Jun 2011 05:00:00 +0100

Updated Date: Jun 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CHILDRENS ALLEGRA ALLERGY (Fexofenadine Hydrochloride) Suspension [Chattem, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 28 Jun 2011 05:00:00 +0100

Updated Date: Jun 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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An alternative approach to community consultation for emergency research without informed consent

The American Journal of Emergency Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Critically ill or injured patients often cannot give informed consent to be enrolled in clinical trials. In 1996, the US government passed a rule (21 CRF 50.24) to allow research without informed consent in emergency situations. One of the requirements of the rule is “community consultation” (CC), that is, advance disclosure of the research plan with the community where the study will be conducted and solicitation of opinions regarding the acceptability of the research. However, there are no clear definitions or guidance that helps investigators and institutional review boards decide how to perform CC properly. In the past, CC has been done with advertisements in print or electronic media, random dialing surveys , and/or town hall meetings . These methodologies may be costly, time cons...

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [NCS HealthCare Of KY, Inc Dba Vangard Labs]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy

JNCI — Mon, 06 Jun 2011 23:00:00 +0100

Conclusions Patients with dMMR colon cancers have reduced rates of tumor recurrence, delayed TTR, and improved survival rates, compared with pMMR colon cancers. Distant recurrences were reduced by 5-FU-based adjuvant treatment in dMMR stage III tumors, and a subset analysis suggested that any treatment benefit was restricted to suspected germline vs sporadic tumors. (Source: JNCI)

Influence of Panax ginseng on Cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) Activity in Healthy Participants.

The Journal of Clinical Pharmacology — Sun, 05 Jun 2011 23:00:00 +0100

Authors: Malati CY, Robertson SM, Hunt JD, Chairez C, Alfaro RM, Kovacs JA, Penzak SR A number of herbal preparations have been shown to interact with prescription medications secondary to modulation of cytochrome P450 (CYP) and/or P-glycoprotein (P-gp). The purpose of this study was to determine the influence of Panax ginseng on CYP3A and P-gp function using the probe substrates midazolam and fexofenadine, respectively. Twelve healthy participants (8 men) completed this open-label, single-sequence pharmacokinetic study. Healthy volunteers received single oral doses of midazolam 8 mg and fexofenadine 120 mg, before and after 28 days of P ginseng 500 mg twice daily. Midazolam and fexofenadine pharmacokinetic parameter values were calculated and compared before and after P ginseng admini...

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Polyarthritis in two travellers returning from Australia

Journal of Clinical Virology — Sun, 05 Jun 2011 23:00:00 +0100

Two young women, 28 and 31 years old, were seen at the travel clinics in Hamburg and Munich, Germany, on the same day (01/Mar/2011) presenting with rash and arthralgia. Two days before contacting our travel clinics, the young women had returned from a joint 30 day-trip to Australia with the following itinerary: Flight to Singapore (29/Jan/2011) with two day stay, flight to Hobart, Tasmania, with ten day stay, flight to Broome, where they rented a camper and drove to Karratha, finally flight to Perth (17/Feb/2011) from where they returned back to Germany (26/Feb/2011). They reported significant mosquito exposure during the five day-trip with the camper, especially during the first night (11/Feb/2011). First symptoms occurred in Perth on 19/Feb/2011. Both patients recognised maculopapular ra...

Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose.

The Journal of Clinical Pharmacology — Tue, 17 May 2011 23:00:00 +0100

Authors: Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y The authors evaluated the contribution of the SLCO2B1 polymorphism to the pharmacokinetics of celiprolol at a microdose (MD) and therapeutic dose (TD) and compared pharmacokinetic proportionality between the 2 dose forms in 30 SLCO2B1 genotype-matched healthy volunteers. Three drugs (celiprolol, fexofenadine, and atenolol) were orally administered as a cassette dosing following the MD (totally 97.5 μg) and then a TD (100 mg) of celiprolol, with and without grapefruit juice. The mean AUC(0-24) of celiprolol was lower in SLCO2B1*3/*3 individuals (775 ng·h/mL) than in *1/*3 (1097 ng·h/mL) and *1/*1 (1547 ng·h/mL) individuals following the TD, and this was confirmed in p...

Evaluation of the genotoxicity and cytotoxicity of fexofenadine in cultured human peripheral blood lymphocytes.

Toxicology in Vitro — Fri, 06 May 2011 23:00:00 +0100

In conclusion, the results of this study suggest that FXF has a cytotoxic effect but not genotoxic effect on human peripheral blood lymphocyte cultures. Further cytogenetic studies, especially about the cell cycle kinetics of FXF are required to elucidate the decreases in dividing cells, and biomonitoring studies should also be conducted with patients receiving therapy with this drug. PMID: 21575710 [PubMed - as supplied by publisher] (Source: Toxicology in Vitro)

Increase of IL-17, IL-22 and IL-23 serum levels induced by immunoglobulin infusion for Parvovirus-B associated Pure Red Cell Aplasia in a renal transplant recipient.

Acta Oncologica — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Alonci A, Penna G, Allegra A, D'Angelo A, Gangemi S, Ferraro M, Spatari G, Bacci F, Gerace D, Musolino C PMID: 21529302 [PubMed - in process] (Source: Acta Oncologica)

BRCA1 is a new MITF target gene.

Pigment Cell and Melanoma Research — Mon, 18 Apr 2011 23:00:00 +0100

Authors: Beuret L, Ohanna M, Strub T, Allegra M, Davidson I, Bertolotto C, Ballotti R PMID: 21501420 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)

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Dr Reddy's launches Fexofenadine HCl in US

The Economic Times Healthcare and Biotech News — Thu, 14 Apr 2011 06:29:06 +0100

Dr Reddy's Laboratories today announced the launch of generic version of Allegra -- Fexofenadine HCl -- tablets in the US market. (Source: The Economic Times Healthcare and Biotech News)

FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 14 Apr 2011 05:00:00 +0100

Updated Date: Apr 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ebastine/fexofenadine: Urticaria: case report

Reactions — Mon, 04 Apr 2011 16:58:12 +0100

(Source: Reactions)

Systematic Review on the Efficacy of Fexofenadine in Seasonal Allergic Rhinitis: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Clinical Trials

International Archives of Allergy and Immunology — Mon, 28 Mar 2011 23:00:00 +0100

Int Arch Allergy Immunol 2011;156:1–15 (DOI:10.1159/000321896) (Source: International Archives of Allergy and Immunology)

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Urticaria due to antihistamines.

Journal of Investigational Allergology and Clinical Immunology — Thu, 17 Mar 2011 04:30:11 +0100

We report a patient with urticaria due to ingestion of ebastine and fexofenadine. Skin prick tests, patch tests, and basophil activation tests with the implicated drugs and antihistamines from other families were negative. The oral challenges with the implicated antihistamines and other antihistamines tested were positive, but the patient tolerated an oral challenge with cetirizine. We present a patient with urticaria induced by different antihistamines in whom the diagnosis was established by oral challenge. The mechanism of sensitization remains unclear. PMID: 21370726 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice

Archives of Dermatological Research — Wed, 02 Mar 2011 06:58:43 +0100

In this study, we investigated the effects of YKS on the development of AD-like lesions in socially isolated NC/Nga mice compared with the effects of fexofenadine and elucidated the mechanism of the ameliorating effect of YKS on the skin lesions. Ten-week-old male NC/Nga mice were divided into three groups (n = 5/group): the conventional control, the YKS-treated, and the fexofenadine-treated groups, and were kept isolated under conventional conditions for 6 weeks. Measurements were made of dermatitis scores and transepidermal water loss (TEWL), scratching and grooming behaviors. Immunohistochemistry and mRNA levels were also evaluated. We performed similar experiments under specific pathogen free (SPF) conditions that served as a SPF control. YKS and fexofenadine inhibi...

Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway

Clinical and Molecular Allergy — Mon, 28 Feb 2011 00:00:00 +0100

Conclusions: This is the first survey to assess the impact on patient-reported outcomes of a mandated switch from prescription to generic antihistamines in Norway. The findings suggest that patient response to different antihistamines will vary and that treatment decisions should be individualized for optimal results. (Source: Clinical and Molecular Allergy)

FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Multilayer, Extended Release [Barr Laboratories Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Feb 2011 05:00:00 +0100

Updated Date: Feb 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Novel strategies for microdose studies using non-radiolabeled compounds.

Advanced Drug Delivery Reviews — Sun, 20 Feb 2011 00:00:00 +0100

Authors: Maeda K, Sugiyama Y Microdose studies using non-radiolabeled compounds enable assessment of the clinical pharmacokinetics of drug candidates in humans without the need to synthesize radiolabeled compounds. We have demonstrated that the quantification limits of many drugs measured by LC-MS/MS are low enough to allow estimation of their pharmacokinetic parameters following administration of a microdose. Our previous microdose studies with LC-MS/MS demonstrated the linear pharmacokinetics of fexofenadine between microdoses and therapeutic doses. We also obtained time profiles of plasma concentrations of nicardipine and its multiple metabolites following administration of a microdose. A significant advantage of using non-radiolabeled compounds is the ability to perform cassette mi...

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The effect of histamine on ciliary beat frequency in the acute phase of allergic rhinitis

American Journal of Otolaryngology — Wed, 09 Feb 2011 05:00:00 +0100

Conclusions: Ciliary beat frequency increased in the acute phase of a mouse model of allergic rhinitis. Physiologic concentrations of histamine had no effect on CBF, and thus, it appears that other mechanisms control CBF in the acute phase of allergic rhinitis. (Source: American Journal of Otolaryngology)

Injunction lifted on Allegra-D 24 Hour

Drug Topics - Top News — Tue, 08 Feb 2011 00:00:00 +0100

Sanofi-Aventis is appealing a federal judge?s decision to lift the injunction against the sale of a generic Allegra D24 product in the United States. (Source: Drug Topics - Top News)

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Dr. Reddy'S Laboratories Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 04 Feb 2011 05:00:00 +0100

Updated Date: Feb 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HYDROCHLORIDEtablet [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Feb 2011 05:00:00 +0100

Updated Date: Feb 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FEXOFENADINE HCL AND PSEUDOEPHEDRINE HCL Tablet, Extended Release [Dr.Reddy'S Laboratories Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Feb 2011 05:00:00 +0100

Updated Date: Feb 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Dr. Reddy's Provides Update on the Fexofenadine-Pseudoephedrine 24 Hour Litigation

Drugs.com - Pharma News — Mon, 31 Jan 2011 16:04:56 +0100

HYDERABAD, India--(BUSINESS WIRE)--Jan 31, 2011 - Dr. Reddy's Laboratories (NYSE: RDY) announced today that on Friday, 28 January 2011, the U.S. District Court of New Jersey filed a Stipulation and Order lifting an earlier motion for preliminary... (Source: Drugs.com - Pharma News)

Dr Reddy's says U.S. court clears generic Allegra sale

Reuters: Health — Mon, 31 Jan 2011 04:23:32 +0100

MUMBAI (Reuters) - India's No.2 drugmaker Dr Reddy's Laboratories Ltd said on Monday a U.S. district court has cleared the sale of its generic version of Sanofi-Aventis' allergy treatment drug Allegra D24. (Source: Reuters: Health)

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Allergy Pill Allegra to Be Sold Over the Counter

Medscape Nurses Headlines — Fri, 28 Jan 2011 16:14:26 +0100

The FDA approves the OTC sale of the popular antihistamine. WebMD Health News (Source: Medscape Nurses Headlines)

FDA Grants OTC Sale for Allergy Drug

MedPage Today Allergy — Thu, 27 Jan 2011 12:43:00 +0100

WASHINGTON (MedPage Today) -- The FDA approved the over-the-counter sale of a line of fexofenadine (Allegra) allergy drugs. (Source: MedPage Today Allergy)

U.S. FDA Approves Number One U.S.-Prescribed Allergy Treatment Allegra(R) For Over-The-Counter Use

Health News from Medical News Today — Thu, 27 Jan 2011 08:00:00 +0100

Sanofi-aventis U.S., and its U.S. Consumer Healthcare Division, Chattem, Inc., announced today that the U.S. Food and Drug Administration (FDA) has approved the Allegra® family of allergy medication products for over-the-counter (OTC) use in adults and children two years of age and older. Additionally, Allegra-D®, which also relieves nasal congestion and sinus pressure, will be available without a prescription at the pharmacy counter for use in adults and children 12 years of age and older... (Source: Health News from Medical News Today)

FDA win throws TN maker of Allegra in overdrive

bizjournals.com Health Care:Pharmaceuticals headlines — Thu, 27 Jan 2011 05:00:00 +0100

(Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Allegra Approved for Over-the-Counter Sale

MedicineNet Allergies General — Wed, 26 Jan 2011 07:00:00 +0100

Title: Allegra Approved for Over-the-Counter SaleCategory: Health NewsCreated: 1/25/2011 8:05:00 PMLast Editorial Review: 1/26/2011 (Source: MedicineNet Allergies General)

Allegra medications sold over-the-counter

Health News - UPI.com — Wed, 26 Jan 2011 05:06:23 +0100

BRIDGEWATER, N.J., Jan. 26 (UPI) -- U.S. regulators have approved has Allegra medications for over-the-counter use in adults and children age 2 and older, the drug's maker says. (Source: Health News - UPI.com)

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Dr. Reddy'S Laboratories Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 26 Jan 2011 05:00:00 +0100

Updated Date: Jan 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

U.S. FDA Approves Number One U.S.-Prescribed Allergy Treatment Allegra for Over-The-Counter Use

HSMN NewsFeed — Wed, 26 Jan 2011 04:17:22 +0100

Allegra® family of products to be available without a prescription across the U.S. this spring allergy season BRIDGEWATER, N.J. and CHATTANOOGA, Tenn., Jan. 25, 2011 (HSMN NewsFeed) -- Sanofi-aventis U.S., and its U.S. Consumer Healthcare Division... Biopharmaceuticals, FDAsanofi-aventis, Allegra (Source: HSMN NewsFeed)

FDA Approves Allegra Sale Without Prescription

WSJ.com: Health — Tue, 25 Jan 2011 22:09:34 +0100

The U.S. FDA gave approval for Sanofi-Aventis to sell its Allegra allergy treatment without a prescription. (Source: WSJ.com: Health)

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Allegra Approved for Over-the-Counter Sale

The Doctors Lounge - Health News — Tue, 25 Jan 2011 21:18:00 +0100

Beginning in March (Source: The Doctors Lounge - Health News)

Great News For Hayfever Sufferers

Forbes.com Healthcare News — Tue, 25 Jan 2011 18:40:54 +0100

It was obvious this was coming when Sanofi-Aventis bought Chattem, the maker of Selsun Blue and other over-the-counter products, but it is still good news for allergy sufferers: Allegra is finally following Merck's Claritin and Pfizer's Zyrtec to over-the-counter status. (Source: Forbes.com Healthcare News)

U.S. FDA Approves Number One U.S.-Prescribed Allergy Treatment Allegra For Over-The-Counter Use

Pharmaceutical Online News — Tue, 25 Jan 2011 08:58:00 +0100

Sanofi-aventis U.S., and its U.S. Consumer Healthcare Division, Chattem, Inc., announced recently that the U.S. Food and Drug Administration (FDA) has approved the Allegra family of allergy medication products for over-the-counter (OTC) use in adults and children two years of age and older. (Source: Pharmaceutical Online News)

U.S. FDA Approves Number One U.S. Prescribed Allergy Treatment Allegra For Over-The-Counter Use

Pharmaceutical Online News — Tue, 25 Jan 2011 08:58:00 +0100

Allergy Pill Allegra To Be Sold Over the Counter

WebMD Health — Tue, 25 Jan 2011 05:00:00 +0100

In time for spring allergy season, the FDA today approved over-the-counter sale of Allegra, a best-selling antihistamine also sold under the generic name fexofenadine. (Source: WebMD Health)

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Allegra Approved for Over-the-Counter Sale

Modern Medicine — Tue, 25 Jan 2011 00:00:00 +0100

(Source: Modern Medicine)

A New Cytochrome P450 Belonging to the 107L Subfamily is Responsible for the Efficient Hydroxylation of the Drug Terfenadine by Streptomyces platensis.

Archives of Biochemistry and Biophysics — Fri, 14 Jan 2011 00:00:00 +0100

We report here the purification and identification of the enzyme responsible for the first step, a cytochrome P450 (P450)-dependent monooxygenase. The corresponding P450, designated P450(terf), was found to catalyze the hydroxylation of the t-butyl group of terfenadine and exhibited UV-visible characteristics of a P450. Its interaction with terfenadine led to a shift of its Soret peak from 418 to 390 nm, as expected for the formation of a P450-substrate complex. In combination with spinach ferredoxin:NADP(+) oxidoreductase and ferredoxin, and in the presence of NADPH, it catalyzed the hydroxylation of terfenadine and some of its analogues, such as terfenadone and ebastine, with Km values at the μM level, and k(cat) values around 30 min(-1). Sequencing of the p450terf gene led to a 1,206 b...

Adjuvant bevacizumab may not be effective for colon cancer

HemOncToday.com — Tue, 11 Jan 2011 09:22:00 +0100

Allegra CJ. J Clin Oncol. 2010; 29:11-16. (Source: HemOncToday.com)

Multiagent Regimens for Metastatic Colorectal Cancer: If Some Is Good, More Must Be Better

JNCI — Tue, 04 Jan 2011 00:00:00 +0100

(Source: JNCI)

Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08 [Gastrointestinal Cancer]

Journal of Clinical Oncology — Wed, 29 Dec 2010 00:00:00 +0100

Conclusion Bevacizumab for 1 year with mFOLFOX6 does not significantly prolong DFS in stages II and III colon cancer. However, a significant but transient effect during bevacizumab exposure was observed in the experimental arm. We postulate that this observation reflects a biologic effect during bevacizumab exposure. Given the lack of improvement in DFS, the use of bevacizumab cannot be recommended for use in the adjuvant treatment of patients with colon cancer. (Source: Journal of Clinical Oncology)

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Adsorption and Aggregation Properties of Norovirus GI and GII Virus-like Particles Demonstrate Differing Responses to Solution Chemistry

Environmental Science and Technology — Wed, 01 Dec 2010 16:46:06 +0100

Environmental Science & TechnologyDOI: 10.1021/es102368d (Source: Environmental Science and Technology)

Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes

European Journal of Human Genetics — Wed, 24 Nov 2010 00:00:00 +0100

Authors: Valerio Napolioni, Federica Lombardi, Roberto Sacco, Paolo Curatolo, Barbara Manzi, Riccardo Alessandrelli, Roberto Militerni, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Cindy Schneider, Raun Melmed, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Francis Rousseau, Patricia Lewin & Antonio M Persico (Source: European Journal of Human Genetics)

ALLEGRA D-12 HOUR (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Extended Release [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 22 Nov 2010 05:00:00 +0100

Updated Date: Nov 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ALLEGRA--D 24 HOUR (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 19 Nov 2010 05:00:00 +0100

Updated Date: Nov 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm: Allegra

fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's Allegra

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