MedWorm: Amantadine

Interventions for fatigue and weight loss in adults with advanced progressive illness.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: There is a lack of robust evidence for interventions to manage fatigue and/or unintentional weight loss in the advanced stage of progressive illnesses such as advanced cancer, heart failure, lung failure, cystic fibrosis, multiple sclerosis, motor neuron disease, Parkinson's disease, dementia and AIDS. The evidence contained within this overview provides some insight into interventions which may prove of benefit within this population such as exercise, some pharmacological treatments and support for self management.Researchers could improve the methodological quality of future studies by blinding of outcome assessors. Adopting uniform reporting mechanisms for fatigue and weight loss outcome measures would also allow the opportunity for meta-analysis of small studies.Researcher...

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Amantadine and rimantadine for influenza A in children and the elderly.

Cochrane Database of Systematic Reviews — Thu, 26 Jan 2012 08:18:08 +0100

CONCLUSIONS: AMT is effective in preventing influenza A in children but the NNTB is high (NNTB: 12 (95% CI 9 to 17). RMT probably helps the abatement of fever on day three of treatment, but the quality of the evidence is poor. Due to the small number of available studies, we could not reach a definitive conclusion on the safety of AMT or the effectiveness of RMT in preventing influenza in children and the elderly. PMID: 22258950 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

AMANTADINE HCL (Amantadine Hydrochloride) Capsule, Liquid Filled [Banner Pharmacaps Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 Jan 2012 05:00:00 +0100

Updated Date: Jan 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HYDROCHLORIDEcapsule, Gelatin Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 03 Jan 2012 05:00:00 +0100

Updated Date: Jan 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HYDROCHLORIDEsolution [Carolina Medical Products Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 30 Dec 2011 05:00:00 +0100

Updated Date: Dec 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Dopamine agonists for the treatment of cocaine dependence.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: Current evidence from randomised controlled trials does not support the use of dopamine agonists for treating cocaine dependence. This absence of evidence may leave to clinicians the alternative of balancing the possible benefits against the potential adverse effects of the treatment. Even the potential benefit of combining a dopamine agonist with a more potent psychosocial intervention which was suggested by the previous Cochrane review (Soares 2003), is not supported by the results of this updated review. PMID: 22161376 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry.

Analytical and Bioanalytical Chemistry — Fri, 16 Dec 2011 05:00:00 +0100

Authors: Berendsen BJ, Wegh RS, Essers ML, Stolker AA, Weigel S Abstract A liquid chromatography-tandem mass spectrometry method for the analysis of seven antiviral drugs, zanamivir, ribavirin, oseltamivir, oseltamivir carboxylate, amantadine, rimantadine and arbidol, in poultry muscle is reported. The antiviral drugs were extracted from the homogenized poultry muscle sample using methanol. The extract was purified using tandem solid-phase extraction combining a cation exchange cartridge and a phenylboronic acid cartridge. To prevent excessive matrix effects, the analytes were separated from the matrix constituents using a column-switch liquid chromatography system combining a reversed-phase and a Hypercarb analytical column. Detection was carried out using tandem mass spectrometry...

Genomic signatures and antiviral drug susceptibility profile of A(H1N1)pdm09

Journal of Clinical Virology — Fri, 16 Dec 2011 05:00:00 +0100

We report several point mutations with putative roles in viral fitness and virulence, and discuss their potential to result in more virulent phenotypes. Monitoring of specific mutations and genetic patterns in influenza viral genes is essential for risk assessing emergent strains, disease epidemiology and public health implications. (Source: Journal of Clinical Virology)

AMANTADINE HYDROCHLORIDEtablet [Upsher-Smith Laboratories, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 15 Dec 2011 05:00:00 +0100

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03.

Antiviral Research — Wed, 14 Dec 2011 05:00:00 +0100

In this report, the inhibitory activity of p-KG03 against influenza virus was examined and compared with that of other sulfated polysaccharides (fucoidan and pentosan polysulfate) and antiviral agents (oseltamivir phosphate, oseltamivir carboxylate, amantadine, and ribavirin). The results of a cytopathic effect reduction assay using MDCK cells demonstrated that p-KG03 exhibited the 50% effective concentration (EC(50)) values of 0.19-0.48μg/ml against influenza type A virus infection (selectivity index >200) but not all influenza type B viruses. Mechanism studies showed that inhibition of influenza virus replication was maximized when p-KG03 was added during or within 6h after viral infection, suggesting that mainly the viral adsorption and internalization steps are targeted by this com...

Phosphonium-Containing Polyelectrolytes for Nonviral Gene Delivery.

Biomacromolecules — Mon, 12 Dec 2011 05:00:00 +0100

Authors: Hemp ST, Allen MH, Green MD, Long TE Abstract Nonviral gene therapy focuses intensely on nitrogen-containing macromolecules and lipids to condense and deliver DNA as a therapeutic for genetic human diseases. For the first time, DNA binding and gene transfection experiments compared phosphonium-containing macromolecules with their respective ammonium analogs. Conventional free radical polymerization of quaternized 4-vinylbenzyl chloride monomers afforded phosphonium- and ammonium-containing homopolymers for gene transfection experiments of HeLa cells. Aqueous size exclusion chromatography confirmed similar absolute molecular weights for all polyelectrolytes. DNA gel shift assays and luciferase expression assays revealed phosphonium-containing polymers bound DNA at lower cha...

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AMANTADINE HYDROCHLORIDEcapsule [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 06 Dec 2011 05:00:00 +0100

Updated Date: Dec 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HYDROCHLORIDEcapsule [Sandoz Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Dec 2011 05:00:00 +0100

Updated Date: Dec 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HYDROCHLORIDEcapsule, Gelatin Coated [Upsher-Smith Laboratories, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Dec 2011 05:00:00 +0100

Updated Date: Dec 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amantadine overdose: Various toxicities: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

(Source: Reactions)

AMANTADINE HYDROCHLORIDEcapsule, Gelatin Coated [UDL Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Nov 2011 05:00:00 +0100

Updated Date: Nov 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Molecular characterization and antiviral activity test of common drugs against echovirus 18 isolated in Korea

Virology Journal — Fri, 11 Nov 2011 05:00:00 +0100

Genetic diversity and antiviral activity for five common antiviral drugs of echovirus (ECV) 5 isolated in Korea have been described. The present study extended these tests to a Korean ECV 18 isolate. The isolate was completely sequenced and antiviral activity testing for azidothymidine, acyclovir, amantadine, lamivudine, and ribavirin were conducted, as for ECV5. An outbreak of aseptic meningitis caused by the ECV 18 isolate was reported in Korea in 2005, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from stool specimen of a 5-year-old male patient with aseptic meningitis, the complete genome sequence was obtained and compared it with the Metcalf prototype strain. Unlike the ECV5 isolate, the 3' no...

AMANTADINE HYDROCHLORIDEcapsule [Upsher-Smith Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Nov 2011 05:00:00 +0100

Updated Date: Nov 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The new platinum-based anticancer agent LA-12 induces Retinol Binding Protein 4 in vivo

Proteome Science — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: RBP4 induction is in agreement with known RBP4 regulation by amantadine and cisplatin. Since retinol metabolism is disrupted in many cancers and inversely associates with malignancy, these data identify a potential novel mechanism for the action of LA-12 and other similar anti-cancer drugs. (Source: Proteome Science)

Microglia-inhibiting activity of Parkinson's disease drug amantadine.

Neurobiology of Aging — Thu, 27 Oct 2011 04:00:00 +0100

This study investigated whether the drug has an inhibitory effect on microglial activation and neuroinflammation, which have been implicated in the progression of neurodegenerative processes. Using cultured microglial cells, it was demonstrated that the drug inhibited inflammatory activation of microglia and a signaling pathway that governs the microglial activation. The drug reduced the expression and production of proinflammatory mediators in bacterial lipopolysaccharide-stimulated microglia cells. The microglia-inhibiting activity of amantadine was also demonstrated in a microglia/neuron coculture and animal models of neuroinflammation and Parkinson's disease. Collectively, our results suggest that amantadine may act on microglia in the central nervous system to inhibit their inflammato...

Antiviral activity of arbidol, a broad‐spectrum drug for use against respiratory viruses, varies according to test conditions

Journal of Medical Virology — Tue, 25 Oct 2011 04:00:00 +0100

AbstractThe therapeutic activity of arbidol was investigated against representatives of seven different virus families. Its 50% median effective concentration (EC50) was 0.22–11.8 µg/ml (0.41–22 nM). Therapeutic indices of 91 were obtained for type 1 poliovirus and 1.9–8.5 for influenza A and B, human paramyxo‐3, avian infectious bronchitis‐, and Marek's disease viruses. Arbidol was more inhibitory for influenza A/Aichi/2/68 (H3N2) virus than rimantadine or amantadine (EC50 10 vs. >15 and >31.6 µg/ml); greater inhibition occurred when end‐points were expressed as TCID50s. For respiratory syncytial virus (RSV), a reduction in plaque size but not number was observed. However, when the drug was added to infected cultures (≥5 µg/ml), a 3‐log reduction in titer ...

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5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives.

International Journal of Biological Macromolecules — Tue, 25 Oct 2011 04:00:00 +0100

Authors: Al-Mohizea AM, Al-Omar MA, Abdalla MM, Amr AG Abstract We herein report the 5α-reductase inhibitors, antiviral and anti-tumor activities of some synthesized heterocyclic cyanopyridone and cyanothiopyridone derivatives fused with steroidal structure. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). All the compounds, except 3b, were interestingly less toxic than the reference drug (Prednisolone(®)). Seventeen heterocyclic derivatives containing a cyanopyridone or cyanothiopyridone rings fused to a steroidal moiety were synthesized and screened for their 5α-reductase inhibitors, antiviral and anti-tumor activities comparable to that of Anastrozole, Bicalutamide, Efavirenz, Capravirine, Ribavirin, Oseltamivir and Amantadine a...

Likely Amantadine‐Induced Livedo Reticularis in a Child

Pediatric Dermatology — Thu, 13 Oct 2011 04:00:00 +0100

We present an 11‐year‐old boy with livedo reticularis (LR) secondary to amantadine treatment for his attention deficit hyperactivity disorder (ADHD). We are unaware of previous reports of amantadine‐induced LR associated with treatment for ADHD in the pediatric population. (Source: Pediatric Dermatology)

A Drosophila Model for Genetic Analysis of Influenza Viral/Host Interactions [Cellular Genetics]

Genetics — Wed, 12 Oct 2011 04:00:00 +0100

Influenza viruses impose a constant threat to vertebrates susceptible to this family of viruses. We have developed a new tool to study virus–host interactions that play key roles in viral replication and to help identify novel anti-influenza drug targets. Via the UAS/Gal4 system we ectopically expressed the influenza virus M2 gene in Drosophila melanogaster and generated dose-sensitive phenotypes in the eye and wing. We have confirmed that the M2 proton channel is properly targeted to cell membranes in Drosophila tissues and functions as a proton channel by altering intracellular pH. As part of the efficacy for potential anti-influenza drug screens, we have also demonstrated that the anti-influenza drug amantadine, which targets the M2 proton channel, suppressed the UAS-M2 mutant phe...

Triple combination antiviral drug for pandemic H1N1 in critically ill patients on mechanical ventilation.

Antimicrobial Agents and Chemotherapy — Mon, 03 Oct 2011 04:00:00 +0100

Authors: Kim WY, Suh GY, Huh JW, Kim SH, Kim MJ, Kim YS, Kim HR, Ryu YJ, Han MS, Ko YG, Chon GR, Lee KH, Choi SH, Hong SB, Abstract Recent in vitro study showed that the three compounds of antiviral drugs with different mechanisms of action (amantadine, ribavirin, and oseltamivir) could result in synergistic antiviral activity. However, no clinical studies have evaluated the efficacy and safety of combination antiviral therapy in patients with severe influenza illness. 245 adult patients who were critically ill with confirmed pandemic influenza A/H1N1 2009 (pH1N1) infection and were admitted to one of the intensive care units (ICUs) of 28 hospitals in Korea were reviewed. Patients who required ventilator support and received either triple combination antiviral drug (TCAD) therapy ...

Multiple impulse control disorders developing in Parkinson's disease after initiation of amantadine

Movement Disorders — Tue, 27 Sep 2011 04:00:00 +0100

(Source: Movement Disorders)

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Psychopharmacological Neuroprotection in Neurodegenerative Diseases, Part III: Criteria-Based Assessment: A Report of the ANPA Committee on Research [SPECIAL ARTICLES]

J Neuropsychiatry Clin Neurosci — Fri, 23 Sep 2011 04:00:00 +0100

This report identifies FDA-approved, first-line psychotropic drugs affecting intracellular mechanisms and meriting disease-modifying clinical trials in NDDs. The authors evaluated evidence for neuroprotection according to 1) preclinical; and 2) clinical criteria. Despite low-to-moderate preclinical evidence scores and scant clinical evidence, the most promising investigative priorities are 1) lithium and paroxetine in Alzheimer's disease (AD); 2) lithium in tauopathies (frontotemporal lobar degeneration [FTLD], FTDP-17); 3) lithium-plus-valproate in AD and amyotrophic lateral sclerosis; 4) pramipexole and valproate in Parkinson's disease; 5) amantadine and buspirone in multiple system atrophy; and 6) antidepressants in Huntington's disease. Preliminary clinical results signal caution regar...

Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease

Movement Disorders — Fri, 23 Sep 2011 04:00:00 +0100

AbstractL‐Dopa‐induced dyskinesia in patients with Parkinson's disease can be alleviated by amantadine, an antagonist at N‐methyl‐D‐aspartate glutamate receptors. The antiepileptic drug topiramate, which blocks α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors, has also been shown to reduce dyskinesia. The purpose of this study was to examine the behavioral pharmacology of topiramate alone and in combination with amantadine in animal models of PD and L‐dopa‐induced dyskinesia. The effects of topiramate (5–20 mg/kg) and amantadine (5–20 mg/kg) on abnormal involuntary movements (the rat homologue of dyskinesia) and Rotarod performance were assessed alone and in combination in the 6‐hydroxydopamine‐lesioned rat following chronic L‐dopa treat...

Amantadine/istradefylline/pramipexole/quetiapine: Hallucinations, compulsive eating and sedation: 5 case reports

Reactions — Thu, 22 Sep 2011 07:55:36 +0100

(Source: Reactions)

Higher free d-aspartate and N-methyl-d-aspartate levels prevent striatal depotentiation and anticipate l-DOPA-induced dyskinesia.

Experimental Neurology — Sat, 17 Sep 2011 04:00:00 +0100

In this study, we examined the influence of a basal corticostriatal hyper-glutamatergic transmission in the appearance of dyskinesia, using a genetic mouse model lacking d-Aspartate Oxidase (DDO) enzyme (Ddo(-/-) mice). We found that, in Ddo(-/-) mice, non-physiological, high levels of the endogenous free d-amino acids d-aspartate (d-Asp) and NMDA, known to stimulate NMDAR transmission, resulted in the loss of corticostriatal synaptic depotentiation and precocious expression of LID. Interestingly, the block of depotentiation precedes any change in dopaminergic transmission associated to 6-OHDA lesion and l-DOPA treatment. Indeed, lesioned mutant mice display physiological l-DOPA-dependent enhancement of striatal D1 receptor/PKA/protein phosphatase-1 and ERK signaling. Moreover, in line wit...

AMANTADINE HYDROCHLORIDEcapsule, Gelatin Coated [Upsher-Smith Laboratories, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 16 Sep 2011 05:00:00 +0100

Updated Date: Sep 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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AMANTADINE HYDROCHLORIDEsolution [Qualitest Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Sep 2011 05:00:00 +0100

Updated Date: Sep 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Livedo reticularis from amantadine.

Skinmed — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Xu LY, Liu A, Kerr HA Abstract A 70-year-old Caucasian man with a medical history of Parkinson's disease presented with a 3-month history of violaceous reticulated patches on his upper and lower extremities. The lesions were asymptomatic. The patient did not have a history of cardioembolic events or autoimmune disorders. No new medications were started before the onset of the lesions. Review of systems was unremarkable. On examination, large erythematous to violaceous patches were present in a reticulated net-like pattern on the patient's upper and lower extremities (Figure 1 and Figure 2). No edema, erosions, or ulcerations were noted. An extensive workup for autoimmune, infectious, and hematologic causes of livedo reticularis was performed. Complete blood cell count, ant...

Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation

Journal of Neural Transmission — Wed, 31 Aug 2011 15:54:33 +0100

Abstract A significant proportion of patients with Parkinson’s disease (PD) receiving dopamine replacement therapy in the form of levodopa develop dyskinesia that becomes a major complicating factor in treatment. Dyskinesia can only be effectively treated by a reduction in drug dose, which limits efficacy, by co-administration of the weak NMDA antagonist amantadine or by surgical treatment (pallidotomy, DBS). This raises the important question of why dyskinesia occurs in PD and how it can be avoided or suppressed by pharmacological treatment. This review assesses some of the mechanisms that underlie dyskinesia induction and expression from presynaptic changes in dopaminergic neurones to postsynaptic alterations in basal ganglia function and examines potential approaches ...

Quetiapine: Tardive dyskinesia treated with amantadine: case report

Reactions — Mon, 29 Aug 2011 14:09:06 +0100

(Source: Reactions)

AMANTADINE HYDROCHLORIDEsolution [Qualitest Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 26 Aug 2011 05:00:00 +0100

Updated Date: Aug 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Current Options and Future Prospects for the Treatment of Dyskinesia and Motor Fluctuations in Parkinson's Disease.

CNS and Neurological Disorders Drug Targets — Sun, 14 Aug 2011 23:00:00 +0100

Authors: Cenci MA, Ohlin KE, Odin P Abstract Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major challenge to a successful clinical management of this disorder. There are currently two main treatment options for these complications, namely, deep brain electrical stimulation or continuous dopaminergic agonist infusion. The latter is achieved using either subcutaneous apomorphine infusion or intrajejunal L-DOPA infusion. Some patients also benefit from the antidyskinetic effect of amantadine as an adjunct to L-DOPA treatment. Ongoing research in animal models of PD aims at disovering additional, novel treatment options that can either prevent or reverse dyskinesia and motor fluc...

Impulsive–compulsive behaviors are common in Asian Parkinson’s disease patients: Assessment using the QUIP

Parkinsonism and Related Disorders — Fri, 12 Aug 2011 04:00:00 +0100

Conclusions: Our findings suggest that Asian patients with Parkinson’s disease may be susceptible to dopaminergic medication-related side effects. The data here also contribute to the understanding of the psychometric properties of the Questionnaire for Impulsive–Compulsive Disorders. (Source: Parkinsonism and Related Disorders)

Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-d-aspartate receptor and voltage gated calcium channel ligands.

European Journal of Medicinal Chemistry — Wed, 10 Aug 2011 23:00:00 +0100

Authors: Joubert J, Dyk SV, Green IR, Malan SF Abstract A series of polycyclic fluorescent ligands were synthesised and evaluated in murine striatal synaptoneurosomes for N-methyl-d-aspartate receptor (NMDAR) mediated calcium flux inhibition and inhibition of calcium influx through voltage gated calcium channels (VGCC). Amantadine (a) and N-(1-adamantyl)-1,3-propanediamine (c) substituted with 1-cyanoisoindole (3), indazole (5), dinitrobenzene (7, 8), dansyl (9, 10) and coumarin (11) moieties showed moderate to high inhibition of the NMDAR. A high degree of VGCC inhibition was observed for the cyanoisoindole compounds (3, 4) the dansyl compounds (9, 10) and the coumarin compound (12). Fluorophores conjugated to hydroxy-4-aza-8-oxoheptacyclotetradecane (13, 14) did not exhibit any s...

P.07 The role of amantadine in motor complications after deep brain stimulation for Parkinson's disease

Journal of Neurology, Neurosurgery and Psychiatry — Sat, 06 Aug 2011 23:00:00 +0100

We report a series of 8 cases who had bilateral STN DBS. These patients had similar characteristics to our local database of patients who have had DBS. However, these patients had disabling bradykinesia and/or dyskinesias despite attempts at optimisation of stimulator settings and dopaminergic medication. The addition of amantadine led to clear improvements in dsykinesias and/or mobility, without the need to increase the total dose of dopaminergic medication. Stopping amantadine caused worsening of symptoms. This case series suggests amantadine is an important additional medication in the small group of patients whose disease has not been stabilised after DBS. The outflow of the STN includes a glutamatergic pathway. The glutamate receptor blocking properties of amantadine provide a possibl...

AMANTADINE HCL (Amantadine Hydrochloride) Capsule [AvPAK]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 05 Aug 2011 05:00:00 +0100

Updated Date: Aug 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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AMANTADINE HYDROCHLORIDEsolution [Morton Grove Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 01 Aug 2011 05:00:00 +0100

Updated Date: Aug 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HCL (Amantadine Hydrochloride) Capsule [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jul 2011 05:00:00 +0100

Updated Date: Jul 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Treatment of Apathy in Huntington’s Disease and Other Movement Disorders

Current Treatment Options in Neurology — Thu, 28 Jul 2011 15:54:04 +0100

Opinion statement Apathy is one of the most prevalent neurobehavioral symptoms in Huntington’s disease (HD), occurring in approximately 70% of the symptomatic HD population. Apathy scores in patients with HD are highly correlated with duration of illness, suggesting that apathy is an inevitable consequence of advanced disease. Although less distressing than symptoms like depression and less disruptive than irritability or aggression, apathy has a considerable adverse impact on those affected with HD because it leads to a decrease of the goal-directed behaviors that contribute much to the day-to-day quality of life. As a neuropsychiatric syndrome, apathy is also common in patients with other neuropsychiatric disorders such as Parkinson’s disease, traumatic brain injury,...

Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry.

Herpes — Wed, 13 Jul 2011 17:45:46 +0100

Authors: Chan D, Tarbin J, Sharman M, Carson M, Smith M, Smith S A screening method for the analysis of seven anti-viral drugs in poultry tissue has been developed. These include anti-influenza drugs (amantadine, rimantadine, zanamivir and oseltamivir and its carboxylate metabolite), anti-herpes drugs (acyclovir and ganciclovir) and an immunomodulator (imiquimod). Poultry tissue was extracted in acetonitrile:water:acetic acid. After sample purification, using a strong cation exchange column, the eluate was split into two fractions. The first portion was dissolved in methanol:water and the second in acetonitrile:methanol:water. Both fractions were analysed on a zwitterionic hydrophilic interaction liquid chromatography column coupled to a triple quadrupole mass spectrometer. The screeni...

AMANTADINE HYDROCHLORIDEsolution [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 12 Jul 2011 05:00:00 +0100

Updated Date: Jul 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Amantadine attenuates levodopa‐induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels

Journal of Neurochemistry — Thu, 07 Jul 2011 23:00:00 +0100

AbstractAmantadine is the only drug marketed for treating levodopa‐induced dyskinesia. However, its impact on basal ganglia circuitry in the dyskinetic brain, particularly on the activity of striatofugal pathways, has not been evaluated. We therefore used dual probe microdialysis to investigate the effect of amantadine on behavioral and neurochemical changes in the globus pallidus and substantia nigra reticulata (SNr) of 6‐hydroxydopamine hemilesioned dyskinetic mice and rats. Levodopa evoked abnormal involuntary movements (AIMs) in dyskinetic mice, and simultaneously elevated GABA release in SNr (∼3‐fold) but not globus pallidus. Glutamate levels were unaffected in both areas. Amantadine (40 mg/Kg, i.p.), ineffective alone, attenuated (∼50%) AIM expression and prevented the GABA...

Amantadine withdrawal: Parkinsonism-hyperpyrexia syndrome: case report

Reactions — Mon, 27 Jun 2011 18:24:12 +0100

(Source: Reactions)

Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008

Medical Microbiology and Immunology — Tue, 21 Jun 2011 18:00:24 +0100

Abstract European swine influenza A viruses donated the matrix protein 2 as well as the neuraminidase (NA) gene to pandemic influenza A (H1N1) viruses that emerged in 2009. As a result, the latter became amantadine resistant and neuraminidase inhibitor (NAI) susceptible. These recent developments reflecting the close connection between influenza A virus infection chains in humans and pigs urge an antiviral surveillance within swine influenza A viruses. Here, NAI susceptibility of 204 serologically typed swine influenza A viruses of subtypes H1N1, H1N2, and H3N2 circulating in Germany between 1981 and 2008 was analyzed in chemiluminescence-based NA inhibition assays. Mean 50% inhibitory concentrations of oseltamivir and zanamivir indicate a good drug susceptibility of teste...

Effect of intravenous amantadine on dopaminergic-drug-resistant freezing of gait

Parkinsonism and Related Disorders — Mon, 20 Jun 2011 20:52:23 +0100

Freezing of gait (FOG) is one of the most disabling symptoms of Parkinsonism and is observed in the advanced stages of Parkinson’s disease (PD) and Parkinson-plus syndromes, including primary progressive freezing gait (PPFG) and pure akinesia . Freezing interferes with daily activities, increases the risk of falling over, and contributes significantly to an impaired quality of life (QOL) . However, the mechanisms underlying FOG are not fully understood, and treatment is often ineffective . Off-related FOG is improved by dopaminergic drugs, and FOG that is observed at very high doses of dopaminergic drugs is improved by reducing the dose of levodopa. However, FOG that is unresponsive to dopaminergic treatment is refractory to most medications . (Source: Parkinsonism and Related Disorders)

AMANTADINE HYDROCHLORIDEcapsule [Lannett Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 20 Jun 2011 05:00:00 +0100

Updated Date: Jun 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Quetiapine: Tardive dyskinesia treated with amantadine: case report

Reactions — Mon, 13 Jun 2011 16:21:55 +0100

(Source: Reactions)

AMANTADINE HCL (Amantadine Hydrochloride) Capsule [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 13 Jun 2011 05:00:00 +0100

Updated Date: Jun 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amantadine May Improve Consciousness Recovery After TBI

Clinical Neurology News — Tue, 31 May 2011 23:00:00 +0100

Major Finding: Patients had significantly faster functional recovery as measured by the Disability Rating Scale over 4 weeks of treatment with amantadine, compared with patients who received placebo (P = .007). (Source: Clinical Neurology News)

Therapies for dopaminergic‐induced dyskinesias in parkinson disease

Annals of Neurology — Tue, 31 May 2011 23:00:00 +0100

AbstractExisting and emerging strategies for managing L‐dopa–induced dyskinesias (LIDs) in patients with Parkinson disease have involved either delaying the introduction of L‐dopa therapy, treatment with an antidyskinetic agent, using a therapy or delivery system that can provide continuous dopaminergic stimulation, or using novel agents that target receptors implicated in the mechanisms underlying LIDs. Treatment with dopamine agonists such as pramipexole or ropinirole allows levodopa to be delayed, but once levodopa is added to the drug regimen the usual course of onset of dyskinesias is observed. Amantadine, an N‐methyl‐D‐aspartate antagonist, is so far the only approved compound with evidence of providing a sustained antidyskinetic benefit in the absence of unacceptable sid...

AMANTADINE HCL (Amantadine Hydrochloride) Capsule [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 18 May 2011 05:00:00 +0100

Updated Date: May 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Molecular Imaging of Cell Death in an Experimental Model of Parkinson’s Disease with a Novel Apoptosis-Targeting Peptide

Molecular Imaging and Biology — Fri, 13 May 2011 05:43:07 +0100

Conclusions We conclude that ApoPep-1 is the effective probe for imaging of apoptosis in the MPTP model and can be applied in brain diseases with apoptosis. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0497-zAuthors Min-Jeong Lee, Department of Physiology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaKai Wang, Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaIn-San Kim, Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaByung-Heon Lee, Department of Biochemistry and Cell Bi...

Genetic diversity and antiviral drug resistance of pandemic H1N1 2009 in Lebanon

Journal of Clinical Virology — Wed, 11 May 2011 23:00:00 +0100

Conclusion: Continuous monitoring of oseltamivir susceptibility among H1N1 pdm is essential to guide the effective use of this drug. (Source: Journal of Clinical Virology)

Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GNDF in astroglia.

Neuropharmacology — Tue, 10 May 2011 23:00:00 +0100

In conclusion, we report that amantadine protected dopamine neurons in two PD models through a novel dual mechanism, namely reducing the release of pro-inflammatory factors from activated microglia and increasing the expression of GNDF in astroglia. PMID: 21586298 [PubMed - as supplied by publisher] (Source: Neuropharmacology)

Intravenous amantadine is safe and effective for the perioperative management of patients with Parkinson’s disease

Journal of Neurology — Thu, 05 May 2011 16:35:15 +0100

Content Type Journal ArticlePages 1-2DOI 10.1007/s00415-011-6083-0Authors Young Eun Kim, Department of Neurology and Movement Disorder Center, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744 KoreaHan-Joon Kim, Department of Neurology and Movement Disorder Center, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744 KoreaJi Young Yun, Department of Neurology and Movement Disorder Center, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744 KoreaBeom S. Jeon, Department of Neurology and Movement Disorder Center, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744 Korea Journal Journal of NeurologyOnline ISSN 1432-1459Print ISSN 0340-5354 (Source: Journal of Neurology)

Milestones in Parkinson's disease therapeutics

Movement Disorders — Sat, 30 Apr 2011 23:00:00 +0100

AbstractIn the mid‐1980s, the treatment of Parkinson's disease was quite exclusively centered on dopatherapy and was focusing on dopamine systems and motor symptoms. A few dopamine agonists and a monoamine oxidase B inhibitor (selegiline) were used as adjuncts in advanced Parkinson's disease. In the early 2010s, levodopa remains the gold standard. New insights into the organization of the basal ganglia paved the way for deep brain stimulation, especially of the subthalamic nucleus, providing spectacular improvement of drug‐refractory levodopa‐induced motor complications. Novel dopamine agonists (pramipexole, ropinirole, rotigotine), catecholmethyltransferase inhibitors (entacapone), and monoamine oxidase B inhibitors (rasagiline) have also been developed to provide more continuous or...

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Phylogenetic Analysis of an Off-Seasonal Influenza Virus A (H3N2) in Niigata, Japan, 2010.

Japanese Journal of Infectious Diseases — Sat, 30 Apr 2011 23:00:00 +0100

The objective of this study was to characterize the off-seasonal influenza virus A subtype H3N2, which caused an outbreak in an elderly hospital in Niigata, Japan. Virus isolates were subtyped by the hemagglutination-inhibition test and screened for antiviral drug sensitivity by real-time PCR using cycling probe technology the and 50% inhibitory concentration (IC(50)) method. Whole genome sequencing was performed in order to determine the phylogeny of the outbreak virus. Seven virus isolates were analyzed in this study, and the results showed that all belonged to the influenza virus A (H3N2). These viruses exhibited the S31N mutation in M2, which confers resistance to amantadine. The results of the IC(50) analysis showed that these viruses were sensitive to both oseltamivir and zanamivir. ...

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

Journal of Veterinary Pharmacology and Therapeutics — Fri, 29 Apr 2011 00:38:15 +0100

This study examined the effect of amantadine, an N‐methyl‐d‐aspartate receptor antagonist, on the thermal antinociceptive effect of oxymorphone in cats. Six adult healthy cats were used. After baseline thermal threshold determinations, oxymorphone was administered intravenously to maintain plasma oxymorphone concentrations of 10, 20, 50, 100, 200, and 400 ng/mL. In addition, amantadine, or an equivalent volume of saline, was administered intravenously to maintain a plasma amantadine concentration of 1100 ng/mL. Thermal threshold and plasma oxymorphone and amantadine concentrations were determined at each target plasma oxymorphone concentration. Effect maximum models were fitted to the oxymorphone concentration–thermal threshold data, after transformation in % maximum response. ...

AMANTADINE HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 28 Apr 2011 05:00:00 +0100

Updated Date: Apr 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Increased perfusion in supplementary motor area during a REM sleep behaviour episode

Sleep Medicine — Mon, 25 Apr 2011 15:05:17 +0100

We report here the results of single photon emission computed tomography (SPECT) during an episode of RBD in a 54-year-old right-handed man with a 3-year history of probable MSA-C (predominance of cerebellar ataxia) . Dream-enacting behaviours consisted of talking, crying and moving, usually violent with frequent injuries. Treatment included L-dopa and amantadine. A polysomnography (PSG) showed profound REM sleep disturbances characterised by an increase of phasic and tonic muscle activities (8% of REM sleep atonia) with an abnormal REM sleep behaviour. A second video-PSG was conducted with a catheter set up prior to sleep. A sudden onset of motor behaviour in REM sleep was detected at 03:57h, followed by 99mTc Ethyl Cysteinate Dimer injection 14se later and SPECT acquisition 90min after t...

Amantadine: Corneal oedema: case report

Reactions — Sat, 16 Apr 2011 17:06:15 +0100

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Amantadine: Corneal oedema in an elderly patient: case report

Reactions — Sat, 16 Apr 2011 17:06:15 +0100

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Amantadine: Corneal oedema: case report

Reactions — Sat, 16 Apr 2011 17:06:15 +0100

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Amantadine/aripiprazole/lithium: Visual hallucinations and parkinsonism: 2 case report

Reactions — Tue, 12 Apr 2011 16:15:37 +0100

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AMANTADINE HYDROCHLORIDEsolution [Carolina Medical Products Company]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 06 Apr 2011 05:00:00 +0100

Updated Date: Apr 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Parkinsonism-hyperpyrexia syndrome due to abrupt withdrawal of amantadine.

Hong Kong Med J — Thu, 31 Mar 2011 23:00:00 +0100

Authors: Cheung YF, Hui CH, Chan JH PMID: 21471604 [PubMed - in process] (Source: Hong Kong Med J)

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Clinical features of nine patients with alternating hemiplegia of childhood

Journal of Paediatrics and Child Health — Tue, 29 Mar 2011 23:00:00 +0100

Conclusion: Trials on new agents like amantadine are necessary for more effective control of the disease. (Source: Journal of Paediatrics and Child Health)

Emerging therapies for dopaminergic‐induced dyskinesias in Parkinson's disease

Annals of Neurology — Wed, 16 Mar 2011 00:00:00 +0100

AbstractEmerging strategies for managing levodopa‐induced dyskinesias (LIDs) in patients with PD has involved either delaying the need for introducing levodopa therapy, treatment with an anti‐dyskinetic agent, using a therapy or delivery system that can provide continuous dopaminergic stimulation, or using novel agents that target receptors implicated in the mechanisms underlying LIDs. Treatment with dopamine agonists such as pramipexole or ropinirole allows the need for levodopa to be delayed, but once levodopa is added to the drug regimen the usual course of onset of dyskinesias is observed. Amantadine, an NMDA antagonist, is so far the only approved compound with evidence of providing a sustained antidyskinetic benefit in the absence of unacceptable side effects. These findings supp...

Amantadine: Dropped head syndrome in an elderly patient: case report

Reactions — Sun, 13 Mar 2011 17:03:03 +0100

(Source: Reactions)

Tardive Dyskinesia

Current Treatment Options in Neurology — Wed, 02 Mar 2011 07:03:45 +0100

Opinion statement Tardive dyskinesia (TD) is iatrogenic (drug-induced); hence the best strategy is prevention. Try to limit exposure to any dopamine receptor blocking agents (DRBAs) if possible. These agents may be unavoidable in some psychiatric conditions such as schizophrenia, but alternative therapies can be used in many situations, such as in the treatment of depression, anxiety, gastrointestinal conditions, and other neurologic conditions, including migraines and sleep disorders. When DRBAs are necessary, physicians should prescribe the smallest possible dose and try to taper and stop the drug at the earliest signs of TD. Abrupt cessation should be avoided, as this can worsen symptoms of TD. Always discuss and document the possibility of TD as an adverse effect when ...

The dopamine and cAMP regulated phosphoprotein, 32kDa (DARPP-32) signaling pathway: A novel therapeutic target in traumatic brain injury.

Experimental Neurology — Tue, 01 Mar 2011 00:00:00 +0100

Authors: Bales JW, Yan HQ, Ma X, Li Y, Samarasinghe R, Dixon CE Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated phosphoprotein 32 (DARPP-32) is expressed within striatal medium spiny neurons and regulates striatal function. We found that controlled cortical impact injury in rats produces a chronic decrease in DARPP-32 phosphorylation at threonine-34 and an increase in protein phosphatase-1 activity. There is no effect of injury on threonine-75 phosphorylation or on DARPP-32 protein. Amantadine, shown to be efficacious i...

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Comparison of the efficacies of amantadine treatment of swine-origin influenza virus A H1N1 and seasonal influenza H1N1 and H3N2 in Japan (2008–2009)

Journal of Infection and Chemotherapy — Mon, 28 Feb 2011 06:43:53 +0100

Abstract Amantadine is not thought to be effective for the treatment of swine-origin influenza virus (S-OIV) based on an analysis of genetic sequences of the M2 protein. However, the actual clinical efficacy of amantadine has not been well documented. Here, we were able to compare the efficacies of amantadine and neuraminidase inhibitors. Subjects consisted of 428 patients, including 144 with seasonal influenza (flu) identified between 2008 and 2009, and 284 with S-OIV identified between July 1 and November 30, 2009. Diagnosis of flu was established using a rapid diagnostic kit obtained commercially in Japan. Body temperature sheets were obtained from 95% of the S-OIV patients. Times required to recover normal body temperature were compared among subjects using different a...

Amantadine: Reversible corneal oedema: case report

Reactions — Sun, 27 Feb 2011 18:11:29 +0100

(Source: Reactions)

Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs

Virology Journal — Thu, 24 Feb 2011 00:00:00 +0100

An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with sepsis-like symptoms, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, am...

Warfarin Sodium Tablets (Jantoven), 3mg: Recall - Mislabeled Bottles Containing Higher Dosage

Drugs.com - FDA MedWatch Alerts — Mon, 21 Feb 2011 05:00:00 +0100

Audience: Pharmacy, Family Practice, Consumer [UPDATED 02/21/2011] Expansion of Recall: Affected Products Include Amantadine, Amlodipine, Androxy, Baclofen, Bethanechol, Jantoven and Oxybutynin [Posted 02/17/2011] ISSUE: Upsher-Smith... (Source: Drugs.com - FDA MedWatch Alerts)

Upsher-Smith Laboratories Announces Expansion of Voluntary Nationwide Recall. Affected Products Include Amantadine, Amlodipine, Androxy, Baclofen, Bethanechol, Jantoven® and Oxybutynin

Food and Drug Administration — Sat, 19 Feb 2011 17:58:00 +0100

Upsher-Smith Laboratories, Inc., of Maple Grove, Minnesota is voluntarily expanding its previously announced recall of Jantoven® Warfarin Sodium, USP, 3 mg Tablets to include additional products that were packaged on the same packaging line between May 17, 2010 and November 17, 2010. The company is initiating the recall as a precautionary measure after a bottle labeled as Jantoven® Warfarin Sodium, USP, 3 mg Tablets was found by a retail pharmacy to contain tablets at a higher, 10 mg strength. (Source: Food and Drug Administration)

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Sudden onset of amantadine-induced reversible bilateral corneal edema in an elderly patient: Case report and literature review

Japanese Journal of Ophthalmology — Fri, 18 Feb 2011 06:55:09 +0100

Content Type Journal ArticlePages 71-74DOI 10.1007/s10384-010-0888-8Authors Atsuhiro Hotehama, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, JapanTatsuya Mimura, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, JapanTomohiko Usui, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, JapanHidetoshi Kawashima, Department of Ophthalmology, Saitama Red Cross Hospital, Saitama, JapanShiro Amano, Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan Journal Japanese Journal of OphthalmologyOnline ISSN 1613-2246Print ISSN 0021-5155 Journal Volume Volume 55 Journal Issue Volume 55, Number 1 (Source: Japanese Journal of Ophthalmology)

Pharmacokinetics of amantadine in cats

Journal of Veterinary Pharmacology and Therapeutics — Wed, 16 Feb 2011 00:00:00 +0100

This study reports the pharmacokinetics of amantadine in cats, after both i.v. and oral administration. Six healthy adult domestic shorthair female cats were used. Amantadine HCl (5 mg/kg, equivalent to 4 mg/kg amantadine base) was administered either intravenously or orally in a crossover randomized design. Blood samples were collected immediately prior to amantadine administration, and at various times up to 1440 min following intravenous, or up to 2880 min following oral administration. Plasma amantadine concentrations were determined by liquid chromatography–mass spectrometry, and plasma amantadine concentration–time data were fitted to compartmental models. A two‐compartment model with elimination from the central compartment best described the disposition of amantadine ...

Charging against the Flu: Studying the Virus on the Atomic Level

Scientific American - Official RSS Feed — Thu, 10 Feb 2011 13:00:00 +0100

With the flu now resistant to its two most common medications, doctors and drug developers have grown increasingly puzzled about how to treat the virus. A 900-megahertz magnet is offering some new clues. Biochemists at Florida State University and Brigham Young University have used a 40-ton magnet to obtain atomic-level images of the virus, not only confirming how the bug escapes annihilation but also revealing potential pathways for new drugs.The study focused on influenza A, the virus responsible for pandemic strains--more specifically, on one of the virus’s surface proteins known as M2, which plays an important role in reproduction. Antiviral drugs amantadine and rimantadine, which for years were the most widely used against influenza A viruses, plugged the M2 pathway like bathtub...

Amantadine/levodopa: Dyskinesias in an adolescent: case report

Reactions — Mon, 31 Jan 2011 15:44:00 +0100

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A reporter system for assaying influenza virus RNP functionality based on secreted Gaussia luciferase activity

Virology Journal — Fri, 21 Jan 2011 00:00:00 +0100

Conclusions: This approach provided a rapid, sensitive, and biosafe assay of influenza vRNP function, particularly for the highly pathogenic avian influenza viruses. (Source: Virology Journal)

Emergence and Phylogenetic Analysis of Amantadine-Resistant Influenza A Subtype H3N2 Viruses in Dublin, Ireland, over Six Seasons from 2003/2004 to 2008/2009

Intervirology — Wed, 12 Jan 2011 23:00:00 +0100

Intervirology (DOI:10.1159/000321358) (Source: Intervirology)

Amantadine/bupropion: Cranial myoclonus: 2 case reports

Reactions — Mon, 10 Jan 2011 13:49:21 +0100

(Source: Reactions)

AMANTADINE HYDROCHLORIDEcapsule [STAT RX USA LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 27 Dec 2010 05:00:00 +0100

Updated Date: Dec 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMANTADINE HCL (Amantadine Hydrochloride) Capsule [Rebel Distributors Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 10 Dec 2010 05:00:00 +0100

Updated Date: Dec 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Amantadine use associated with impulse control disorders in Parkinson disease in cross‐sectional study

Annals of Neurology — Wed, 08 Dec 2010 00:00:00 +0100

AbstractA recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross‐sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD. Ann Neurol 2010 (Source: Annals of Neurology)

AMANTADINE HYDROCHLORIDEcapsule [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 07 Dec 2010 05:00:00 +0100

Updated Date: Dec 7, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Mania switch induced by amantadine in bipolar disorder: report of three cases.

Revista Brasileira de Psiquiatria — Wed, 01 Dec 2010 00:00:00 +0100

Authors: Sodré LA, Bücker J, Zortéa K, Sulzbach-Vianna MF, Gama CS PMID: 21308277 [PubMed - in process] (Source: Revista Brasileira de Psiquiatria)

An improved model to investigate the efficacy of antidyskinetic agents in hemiparkinsonian rats.

Neuropharmacology — Tue, 30 Nov 2010 00:00:00 +0100

The objective of the present study was to combine a model of 6-OHDA-induced parkinsonism and of L-DOPA-induced dyskinesia in rats to establish a reliable preclinical model. Two stereotaxic injections of 6-OHDA were administered in the left striatum. This model led to 90-100% of rats with a marked contralateral circling behaviour, significant limb use asymmetry (20%), a decrease in ipsilateral striatal dopamine content (70%) and degeneration of dopamine neurons in the substantia nigra (70%). Chronic treatment with L-DOPA was administered for 35 days and consisted of three phases with incremental daily doses. The third phase resulted in 83-90% of rats developing severe abnormal involuntary movements (AIMs) which included limb and locomotive dyskinesia, axial dystonia and orolingual dyskinesi...

AMANTADINE HYDROCHLORIDEsolution [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 19 Nov 2010 05:00:00 +0100

Updated Date: Nov 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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An improved model to investigate the efficacy of antidyskinetic agents in hemiparkinsonian rats

Fundamental and Clinical Pharmacology — Tue, 16 Nov 2010 00:00:00 +0100

The objective of this study was to combine a model of 6‐OHDA‐induced parkinsonism and of L‐DOPA‐induced dyskinesia in rats to establish a reliable preclinical model. Two stereotaxic injections of 6‐OHDA were administered in the left striatum. This model led to 90–100% of rats with a marked contralateral circling behaviour, significant limb use asymmetry (20%), a decrease in ipsilateral striatal dopamine content (70%) and degeneration of dopamine neurons in the substantia nigra (70%). Chronic treatment with L‐DOPA was administered for 35 days and consisted of three phases with incremental daily doses. The third phase resulted in 83–90% of rats developing severe abnormal involuntary movements (AIMs) which included limb and locomotive dyskinesia, axial dystonia and orolingua...

Pharmacological treatments for fatigue associated with palliative care.

Cochrane Database of Systematic Reviews — Sat, 13 Nov 2010 02:25:04 +0100

CONCLUSIONS: Based on limited evidence, we cannot recommend a specific drug for treatment of fatigue in palliative care patients. Surprisingly, corticosteroids have not been a research focus for fatigue treatment, although these drugs are frequently used. Recent fatigue research seems to focus on modafinil, which may be beneficial although there is no evidence currently. Amantadine and methylphenidate should be further examined. Consensus regarding fatigue assessment in advanced disease is needed. PMID: 21069692 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Management of punding in Parkinson’s disease: an open-label prospective study

Journal of Neurology — Fri, 12 Nov 2010 08:49:22 +0100

Abstract Punding, a peculiar stereotyped behavior characterized by intense fascination with complex, excessive, non-goal-oriented, repetitive activities, is a quite rare condition complicating Parkinson’s disease (PD). It is triggered by dopaminergic therapy and could have a strong impact on patient quality of life. No study has specifically investigated medical management of this condition, and only a few anecdotal reports have provided therapeutic hints. Given the suggested similarities to drug-induced dyskinesias, we have previously suggested a multistep algorithm for management of punding. We conducted a prospective open-label study on ten PD punders aimed at testing its validity. In two cases, reduction of levodopa therapy was efficacious; amantadine was effective i...

Oseltamivir, zanamivir and amantadine in the prevention of influenza: A systematic review

Journal of Infection — Mon, 08 Nov 2010 00:00:00 +0100

Conclusions: Evidence was identified for the efficacy of oseltamivir and zanamivir in preventing influenza in a range of population subgroups. The evidence base for amantadine was considerably more limited. (Source: Journal of Infection)

Open, uncontrolled, nonrandomized, 9-month, off-label use of bupropion to treat fatigue in a single patient with multiple sclerosis.

Clinical Therapeutics — Mon, 01 Nov 2010 00:00:00 +0100

Conclusion: This patient with relapsing-remitting MS experienced improvements in chronic fatigue (as measured by FSS) after treatment with bupropion, but properly designed, randomized, active- and placebo-controlled clinical trials are needed to evaluate the efficacy and safety of bupropion in more patients with MS and fatigue. PMID: 21118738 [PubMed - in process] (Source: Clinical Therapeutics)

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Reply to: Is pathological gambling in parkinson disease reduced by amantadine?

Annals of Neurology — Fri, 29 Oct 2010 19:29:08 +0100

(Source: Annals of Neurology)

AMANTADINE HYDROCHLORIDEcapsule [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 26 Oct 2010 05:00:00 +0100

Updated Date: Oct 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Detailing Influenza's Structure For Drug Targeting

Health News from Medical News Today — Mon, 25 Oct 2010 09:00:00 +0100

Beating the flu is already tough, but it has become even harder in recent years - the influenza A virus has mutated so that two antiviral drugs don't slow it down anymore. Reporting their findings in the journal Science, researchers from Florida State and Brigham Young move closer to understanding why not, and how future treatments can defeat the nasty bug no matter how it changes. The two drugs, amantadine and rimantadine, are no longer recommended by the CDC for use against flu... (Source: Health News from Medical News Today)

Emergence of amantadine-resistant avian influenza H5N1 virus in India

Virus Genes — Sat, 16 Oct 2010 09:03:38 +0100

This study reports the genetic characterization of highly pathogenic avian influenza (HPAI) virus (subtype H5N1) isolated from poultry in West Bengal, India. We analyzed all the eight genome segments of two viruses isolated from chickens in January 2010 to understand their genetic relationship with other Indian H5N1 isolates and possible connection between different outbreaks. The hemagglutinin (HA) gene of the viruses showed multiple basic amino acids at the cleavage site, a marker for high virulence in chickens. Of greatest concern was that the viruses displayed amino acid substitution from serine-to-asparagine at position 31 of M2 ion channel protein suggesting emergence of amantadine-resistant mutants not previously reported in HPAI H5N1 outbreaks in India. Amino acid lysine at p...

Quantification of the Mg(2+)-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs.

Neuropharmacology — Thu, 14 Oct 2010 23:00:00 +0100

This study quantifies the extent to which Mg(2+) alters the potency of the block produced by both amantadine and memantine at human recombinant GluN1/GluN2A NMDARs. Human recombinant GluN1/GluN2A NMDARs were expressed in Xenopus laevis oocytes and two-electrode voltage-clamp recordings were made at -80, -60 and -40 mV to quantify amantadine and memantine block in the absence and presence of Mg(2+). Amantadine and memantine blocked human GluN1/GluN2A NMDARs in a voltage-dependent manner with IC(50) values (at -80 mV) of 49 ± 6 μM (n = 7) and 1.0 ± 0.3 μM (n = 7), respectively. In the presence of Mg(2+) (1 mM) the equivalent IC(50) values were 165 ± 10 μM (n = 6) and 6.6 ± 0.3 μM (n = 5). Similarly in the presence of amantadine or memantine the potency of Mg(2+) in blocking GluN1/Glu...

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NMR Structure of p7 Monomer [Molecular Biophysics]

Journal of Biological Chemistry — Fri, 01 Oct 2010 13:39:19 +0100

In this study, p7 from strain HCV-J (genotype 1b) was chemically synthesized and purified for ion channel activity measurements and structure analyses. p7 forms cation-selective ion channels in planar lipid bilayers and at the single-channel level by the patch clamp technique. Ion channel activity was shown to be inhibited by hexamethylene amiloride but not by amantadine. Circular dichroism analyses revealed that the structure of p7 is mainly -helical, irrespective of the membrane mimetic medium (e.g. lysolipids, detergents, or organic solvent/water mixtures). The secondary structure elements of the monomeric form of p7 were determined by 1H and 13C NMR in trifluoroethanol/water mixtures. Molecular dynamics simulations in a model membrane were combined synergistically with structural data ...

Differential pharmacological responses of catatonia-like signs in frontotemporal dementia.

Neurocase — Thu, 30 Sep 2010 23:00:00 +0100

Authors: Lauterbach EC, Sharone Kuppuswamy P, Greenway LL Sequential therapeutic trials for catatonoid frontal signs in clinically-evident frontotemporal dementia (n = 2) revealed differential benefits for lorazepam, amantadine, memantine, pramipexole, aripiprazole, quetiapine, citalopram, and donepezil, although certain signs also worsened. Citalopram and donepezil were poorly tolerated. Ramelteon was without effect. While memantine appeared to improve cognition in case 1, this remains to be established by more reliable neuropsychological testing. Parkinsonism (case 2) responded to pramipexole, but not amantadine or levodopa. Possible relationships of catatonoid signs requiring future confirmation include insufficient GABA-A (multiple signs) and D2 (mutism) and excessive NMDA (immobil...

Poster 14 (see Article 3): Amantadine Hydrochloride for Treatment of Symptoms of the Posttraumatic Confusional State: A Randomized, Double-Blind, Placebo-Controlled Trial

Archives of Physical Medicine and Rehabilitation — Wed, 29 Sep 2010 17:45:28 +0100

Conclusions: Although the natural course of symptom recovery from PTCS is favorable, these results provide tentative support to reports suggesting that AH safely hastens recovery from nonpenetrating TBI. (Source: Archives of Physical Medicine and Rehabilitation)

Article 3 (see Poster 14): Amantadine Hydrochloride for Treatment of Symptoms of the Posttraumatic Confusional State: A Randomized, Double-Blind, Placebo-Controlled Trial

Archives of Physical Medicine and Rehabilitation — Wed, 29 Sep 2010 17:45:23 +0100

Amantadine: Musical hallucinations in an elderly patient: case report

Reactions — Tue, 21 Sep 2010 07:09:46 +0100

(Source: Reactions)

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Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus.

Bioorganic Chemistry — Mon, 20 Sep 2010 23:00:00 +0100

Authors: Fytas C, Kolocouris A, Fytas G, Grigoris Z, Valmas C, Basler CF Spiro[piperidine-2,2'-adamantane] 4 is one of the most potent synthetic anti-influenza A aminoadamantanes or other cage structure amines tested so far. Based on previous results Tataridis et al. (2007) [5h] which demonstrate the boost of in vitro potency by the presence of an additional amino group, we examined whether the incorporation of a second amino group into this heterocycle would increase the anti-influenza A virus activity. The new synthetic molecules 5-7 are capable of forming two hydrogen bonds within the receptor. We identified the diamino derivatives 5 and 6, which are active against influenza A H3N2 virus although less potent than amantadine and its equipotent spiropiperidine 4. PMID: 20926112 [P...

Amantadine: Corneal oedema in an elderly patient: case report

Reactions — Mon, 13 Sep 2010 05:57:44 +0100

(Source: Reactions)

Amantadine/donepezil: Hallucinations, aggression and irritability in an elderly patient: case report

Reactions — Mon, 13 Sep 2010 05:57:44 +0100

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Molecular characteristics of the human pandemic influenza A virus (H1N1).

Acta Virologica — Sun, 12 Sep 2010 00:24:04 +0100

Authors: Payungporn S, Panjaworayan N, Makkoch J, Poovorawan Y The outbreak of the human pandemic influenza A (H1N1) has caused a considerable public concern. The aim of this review was to improve our understanding of this novel virus by analyzing the relationships between its molecular characteristics and pathogenic properties. Results of this analysis indicate that the human pandemic influenza A (H1N1) virus is a new re-assorted virus, which combines genetic materials from the avian flu (H1N1) virus, classical swine flu (H1N1) virus, human flu (H3N2) virus, and Eurasian swine flu (H1N1) virus. Analysis of the sequences for receptor-binding and cleavage sites of hemagglutinin (HA), stalk region of neuraminidase (NA), non-structural protein 1 (NS1), polymerase basic protein 2 (PB2), an...

Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha

Virology Journal — Thu, 02 Sep 2010 23:00:00 +0100

In conclusion, amantadine, in combination of IFN-alpha, might have a beneficial effect in some patients with acute hepatitis A. (Source: Virology Journal)

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Inhibition of influenza virus replication by plant-derived isoquercetin.

Antiviral Research — Thu, 02 Sep 2010 23:00:00 +0100

Authors: Kim Y, Narayanan S, Chang KO Influenza virus infects the respiratory system of human and animals causing mild to severe illness which could lead to death. Although vaccines are available, there is still a great need for influenza antiviral drugs to reduce disease progression and virus transmission. Currently two classes (M2 channel blockers and neuraminidase inhibitors) of FDA-approved influenza antiviral drugs are available, but there are great concerns of emergence of viral resistance. Therefore, timely development of new antiviral drugs against influenza viruses is crucial. Plant derived polyphenols have been studied for antioxidant activity, anti-carcinogenic, and cardio- and neuroprotective actions. Recently, some polyphenols, such as resveratrol and epigallocatechin gall...

Antivirals for influenza: strategies for use in pediatrics.

Paediatric Drugs — Thu, 02 Sep 2010 04:57:19 +0100

Authors: Smith SM, Gums JG Influenza infection is annually responsible for significant morbidity and mortality, particularly among the very young and old. Recently updated guidelines recommend influenza vaccination of all children aged 6 months to 18 years; however, childhood vaccination remains underutilized. Furthermore, concerns over the reduced efficacy of vaccination in children have further heightened the need for effective treatment schemes. Antiviral therapies have emerged as attractive options in the battle against influenza infection. These agents include the adamantanes (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir, oseltamivir, and peramivir). Broad-scale use of adamantane antivirals has been severely limited in recent years because of high resistance...

Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran.

Antiviral Research — Mon, 30 Aug 2010 23:00:00 +0100

Authors: Yavarian J, Azad TM, Zheng X, Gregory V, Lin YP, Hay A The aminoadamantanes, amantadine and rimantadine, have been used to prevent and treat influenza A virus infections for many years. Several reports have shown an increased level of resistance to these drugs, particularly among influenza A(H3N2) subtype viruses, during recent years. We observed an increase in amantadine resistance, due to a Ser31Asn mutation in the M2 channel protein, among A(H3N2) viruses circulating in Iran during 2005-2007. Sequence analyses of the haemagglutinin and neuraminidase genes as well as the M gene of these viruses revealed that the emergence of resistance was in general consistent with the progressive worldwide evolution of H3N2 viruses. PMID: 20816700 [PubMed - as supplied by publisher] (S...

Long-term amantadine may lead to corneal changes

Reactions — Fri, 13 Aug 2010 05:47:51 +0100

(Source: Reactions)

Application of an In-Cell Western assay for measurement of influenza A virus replication.

Journal of Virological Methods — Wed, 11 Aug 2010 23:00:00 +0100

Authors: Wan Y, Zhou Z, Yang Y, Wang J, Hung T Influenza A pandemics present enormous challenges to modern medicine. To control such pandemics, quantitative assays characterised by rapidity, high sensitivity, and high-throughput are critical in determining the susceptibility of the influenza A virus to antiviral drugs and for screening chemicals that can inhibit viral replication effectively. In the present study, a rapid and quantitative method to determine influenza A virus replication was developed by an In-Cell Western (ICW) assay. This assay was found to be useful for monitoring the kinetics of influenza A virus replication, as viral nucleoprotein production could be correlated to both increasing doses of viral infection and to the lapse of time during viral infection. Compared to...

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Pharmacological interventions for antisocial personality disorder.

Cochrane Database of Systematic Reviews — Sat, 07 Aug 2010 01:33:04 +0100

CONCLUSIONS: The body of evidence summarised in this review is insufficient to allow any conclusion to be drawn about the use of pharmacological interventions in the treatment of antisocial personality disorder. PMID: 20687091 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants.

Chemosphere — Wed, 04 Aug 2010 23:00:00 +0100

Authors: Ghosh GC, Nakada N, Yamashita N, Tanaka H We investigated the occurrence and fate of the two antiviral drugs oseltamivir carboxylate (OC)-the active metabolite of Tamiflu-and amantadine (AMT) at three sewage treatment plants (STPs) during the 2008-2009 and 2009-2010 influenza seasons in Japan. Both compounds were detected in all samples analyzed. The concentrations in raw influents at the STPs ranged from 140 to 460ngL(-1) OC and from 184 to 538ngL(-1) AMT. Primary treatment gave no substantial removal of the drugs (OC, 2-9%; AMT, 7-17%). Biological nutrient-removal-based secondary treatment (anoxic-oxic-anoxic-oxic and anaerobic-anoxic-oxic) removed 20-37% of OC, whereas extended-aeration-based conventional activated sludge treatment removed <20%. STPs using primary plus b...

OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users

Neurogenetics — Mon, 02 Aug 2010 20:27:09 +0100

Abstract Substrates for the Organic Cation Transporter 1, encoded by the SLC22A1 gene, are metformin, amantadine, pramipexole, and, possibly, levodopa. Recently, we identified that the rs622342 A > C polymorphism is associated with the HbA1c lowering effect in metformin users. In the Rotterdam Study, we associated this polymorphism with higher prescribed doses of all anti-Parkinsonian drugs. Between the first and fifth prescriptions for levodopa, for each minor rs622342 C allele, the prescribed doses were 0.34 defined daily dose higher (95% CI 0.064, 0.62; p = 0.017). The mortality ratio after start of levodopa therapy was 1.47 times higher (95% CI 1.01, 2.13; p = 0.045). Content Type Journal ArticleCategory SHORT COMMUNICATIONDOI 10.1007/s10048-010-0254-5Auth...

Amantadine: Encephalopathy, myoclonus and ataxia: case report

Reactions — Sun, 01 Aug 2010 05:35:00 +0100

(Source: Reactions)

Amantadine versus methylphenidate in children and adolescents with attention deficit/hyperactivity disorder: a randomized, double‐blind trial

Human Psychopharmacology: Clinical and Experimental — Sun, 01 Aug 2010 00:00:00 +0100

Conclusion The results of this study indicate that amantadine significantly improved symptoms of ADHD and was well tolerated and it may be beneficial in the treatment of children with ADHD. Nevertheless, the present results do not constitute proof of efficacy. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)

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Use of antiparkinson medications among elderly Medicare beneficiaries with Parkinson's disease.

The American Journal of Geriatric Pharmacotherapy — Sat, 31 Jul 2010 23:00:00 +0100

CONCLUSIONS: Almost half of the elderly Medicare beneficiaries with PD in this study did not use any APD between 2000 and 2003. Levodopa was the most frequently used APD, either as monotherapy or in combination with other APDs. The identified determinants of APD use (age, education, prescription drug coverage, ADLs, dementia, depression, and residing in an institution) may be helpful in developing interventions for this population. PMID: 20869624 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy)

Long‐term antidyskinetic efficacy of amantadine in Parkinson's disease

Movement Disorders — Thu, 29 Jul 2010 23:00:00 +0100

Abstract (Source: Movement Disorders)

Amantadine: Myoclonus in an elderly patient: case report

Reactions — Sun, 25 Jul 2010 05:33:33 +0100

(Source: Reactions)

The Brown University Geriatric Psychopharmacology Update — Wed, 14 Jul 2010 05:44:02 +0100

Study: Current Use of Some Antidepressants Associated With Risk for CataractsSSRI Use Associated With Elevated Risk of Ischemic Stroke in Elderly PersonsQT Interval Prolongation Associated With Ziprasidone and Other DrugsTwo Adjunctive Therapies and EscitalopramCholinesterase Inhibitor Treatment Effects in Drivers With Alzheimer's DiseaseDrug-Related Eye Diseases: Commentary by Paul Koch, M.D.Discontinuing Benzodiazepines in the ElderlyEffects of Amantadine on the CorneaPhase 2 Trial of ADO2 Alzheimer's VaccineNew NIA Booklet on Preventing or Delaying Alzheimer'sLevetiracetam-Induced and Amiodarone-Induced DeliriumNew ApprovalStronger Warnings on Tramadol (Ultram)Drug Safety Labeling Change (Source: The Brown University Geriatric Psychopharmacology Update)

Abstract #13: Low-Dose Naltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study

Neurotherapeutics — Wed, 30 Jun 2010 23:00:00 +0100

Conclusions: In this small, open-label trial, LDN therapy was well tolerated and was associated with equivalent reductions in fatigue compared with historical benchmarks. These observed reductions in fatigue are unlikely to have been a function of any perceived improvements to motor symptoms, because UPDRS scores slightly worsened over the 8-month trial, as expected in this progressive disease. (Source: Neurotherapeutics)

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SSRIs, Amantadine May Affect Vision in Elderly

Medscape Today Headlines — Thu, 24 Jun 2010 21:01:35 +0100

SSRI antidepressants and amantadine have been linked to cataracts and corneal damage, respectively. Medscape Medical News (Source: Medscape Today Headlines)

Parkinson's disease drug can cause corneal damage

Modern Medicine — Thu, 17 Jun 2010 23:00:00 +0100

Parkinson's disease patients taking the drug amantadine are at risk for damage to the corneal endothelium and resulting impaired vision, which can become more pronounced the longer the drug is used, according to research. (Source: Modern Medicine)

Pathway to lamellar bodies for surfactant protein A

AJP: Lung Cellular and Molecular Physiology — Fri, 11 Jun 2010 20:04:58 +0100

Alveolar surfactant protein A (SP-A) is endocytosed by type II epithelial cells through clathrin-dependent uptake and targeted to lamellar bodies for resecretion. However, the mechanism for secretion of newly synthesized SP-A, whether regulated exocytosis of lamellar bodies or constitutive secretion, is unresolved. If it is the latter, lamellar body SP-A would represent endocytosed protein. Amantadine, an inhibitor of clathrin-coated vesicle budding, was used to evaluate the role of endocytosis in accumulation of SP-A in lamellar bodies. In isolated rat lungs, amantadine (10 mM) inhibited uptake of endotracheally instilled 35S-labeled biosynthesized surfactant proteins by >80%. To study trafficking of newly synthesized SP-A, lungs were perfused for up to 6 h with [35S]methionine, and su...

Amantadine-associated corneal edema

Parkinsonism and Related Disorders — Tue, 08 Jun 2010 13:43:46 +0100

Amantadine HCl is an antiviral agent used to treat and prevent influenza A. It is also indicated for the treatment of Parkinsonism and drug-induced extra pyramidal symptoms. Reported ocular side effects include visual loss, hallucination, oculogyric crises, mydriasis, diffuse white punctate subepithelial, opacities, superficial punctate keratitis, epithelial and stromal edema . (Source: Parkinsonism and Related Disorders)

Long-term use of Parkinson's drug may impact vision

ScienceDaily Headlines — Fri, 04 Jun 2010 12:00:00 +0100

Parkinson's disease, the second most common neurodegenerative disease after Alzheimer's, is often treated with amantadine. The drug helps alleviate patients' motor problems and may be taken for years. Doctors have long known that amantadine treatment causes abnormal changes in the cornea in some Parkinson's patients. The cornea is the eye's clear outer surface that provides most of the visual power. Usually corneal reactions occur soon after starting the drug and disappear a few weeks after it is withdrawn. But sometimes corneal disorders appear only after years of treatment, and the corneas of these patients often do not recover when amantadine is stopped. (Source: ScienceDaily Headlines)

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Parkinson's Drug Impacts Vision

Medical Headlines From Ivanhoe.com — Fri, 04 Jun 2010 05:00:00 +0100

(Ivanhoe Newswire) -- Doctors have long known that amantadine treatment causes abnormal changes in the cornea in some Parkinson's patients. (Source: Medical Headlines From Ivanhoe.com)

Parkinson's drug may affect vision

Health News - UPI.com — Fri, 04 Jun 2010 01:59:51 +0100

SEOUL, June 3 (UPI) -- Researchers in South Korea say long-time use of the drug amantadine for Parkinson's may affect vision. (Source: Health News - UPI.com)

How Does Influenza Virus A Escape from Amantadine?

Journal of Physical Chemistry B — Thu, 03 Jun 2010 17:12:29 +0100

The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Physical Chemistry B)

Antidepressants Linked To Cataract Risk; Parkinson's Drug May Cause Corneal Damage

Health News from Medical News Today — Wed, 02 Jun 2010 09:00:00 +0100

This month's Ophthalmology, the journal of the American Academy of Ophthalmology, includes new studies on links between eye diseases and two widely-prescribed drugs: SSRI (selective serotonin reuptake inhibitor) antidepressants, and amantadine, a Parkinson's disease treatment. Some Antidepressants May Bump Up Cataract Risk Seniors who take SSRI antidepressants may be more likely to develop cataracts , says the first major study to examine this interaction... (Source: Health News from Medical News Today)

Cataract Risk From Antidepressants - Parkinson's Drug May Cause Corneal Damage

Health News from Medical News Today — Wed, 02 Jun 2010 08:00:00 +0100

This month's Ophthalmology, the journal of the American Academy of Ophthalmology, includes new studies on links between eye diseases and two widely-prescribed drugs: SSRI (selective serotonin reuptake inhibitor) antidepressants, and amantadine, a Parkinson's disease treatment. Some Antidepressants May Bump Up Cataract Risk Seniors who take SSRI antidepressants may be more likely to develop cataracts, says the first major study to examine this interaction... (Source: Health News from Medical News Today)

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Parkinson's Disease Drug Can Cause Corneal Damage

Modern Medicine — Tue, 01 Jun 2010 23:00:00 +0100

Antidepressants linked to cataract risk -- Parkinson's drug may cause corneal damage

EurekAlert! - Social and Behavioral Science — Tue, 01 Jun 2010 04:00:00 +0100

(American Academy of Ophthalmology) This month's Ophthalmology, the journal of the American Academy of Ophthalmology, includes new studies on links between eye diseases and two widely-prescribed drugs: SSRI (selective serotonin reuptake inhibitor) antidepressants and amantadine, a Parkinson's disease treatment. (Source: EurekAlert! - Social and Behavioral Science)

Oseltamivir-Resistant Influenza Viruses A (H1N1) during 2007-2009 Influenza Seasons, Japan.

Emerging Infectious Diseases — Sun, 30 May 2010 16:44:36 +0100

Authors: Ujike M, Shimabukuro K, Mochizuki K, Obuchi M, Kageyama T, Shirakura M, Kishida N, Yamashita K, Horikawa H, Kato Y, Fujita N, Tashiro M, Odagiri T, To monitor oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y in neuraminidase (NA) in Japan during 2 influenza seasons, we analyzed 3,216 clinical samples by NA sequencing and/or NA inhibition assay. The total frequency of ORVs was 2.6% (45/1,734) during the 2007-08 season and 99.7% (1,477/1,482) during the 2008-09 season, indicating a marked increase in ORVs in Japan during 1 influenza season. The NA gene of ORVs in the 2007-08 season fell into 2 distinct lineages by D354G substitution, whereas that of ORVs in the 2008-09 season fell into 1 lineage. NA inhibition assay and M2 sequencing showed that almost all the...

Transient amantadine-induced musical hallucinations in a patient with Parkinson's disease

Movement Disorders — Mon, 24 May 2010 23:00:00 +0100

No abstract. (Source: Movement Disorders)

Antiviral drug susceptibilities of seasonal human influenza viruses in Lebanon, 2008-09 season

Journal of Medical Virology — Mon, 24 May 2010 23:00:00 +0100

In this study, genetic characteristics and antiviral susceptibility patterns of influenza samples collected in Lebanon during the 2008-09 season were investigated. Forty influenza virus samples were isolated from 89 nasopharyngeal swabs obtained from patients with influenza-like illness. Of these samples, 33 (82.5%) were A(H3N2), 3 (7.5%) were A(H1N1), and 4 (10%) were B. All the H3N2 viruses were resistant to amantadine but were sensitive to oseltamivir and zanamivir; while all the H1N1 viruses were resistant to oseltamivir (possessed H275Y mutation, N1 numbering, in their NA) but were sensitive to amantadine and zanamivir. In the case of influenza B, both Victoria and Yamagata lineages were identified (three and one isolates each, respectively) and they showed decreased susceptibility to...

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Amantadine for treatment of hepatitis C: Time to say “enough is enough”?

Digestive and Liver Disease — Wed, 19 May 2010 23:00:00 +0100

When in the early 1990s it became clear that hepatitis C was a global epidemic, investigators around the world focused on finding an effective treatment. Interferon alpha (IFNα), which had been used for the treatment of chronic hepatitis B, was found to have antiviral activity against the hepatitis C virus (HCV) as well. The first trials of thrice weekly IFNα for 6 months obtained sustained virological response (SVR) rates of approximately 25%; then in the mid-1990s the antiviral ribavirin was found to decrease HCV RNA levels; improved SVR rates were obtained when ribavirin was administered with IFNα, thus ushering the era of combination therapy. In 1997 the National Institutes of Health published their guidelines for the treatment of hepatitis C, which still identified IFNα monotherap...

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents

Journal of Neurochemistry — Wed, 05 May 2010 23:00:00 +0100

In conclusion, OCT1 and OCT2 are important for MPTP transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP and MPTP-induced dopaminergic toxicity in rodents. (Source: Journal of Neurochemistry)

Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application

Electrophoresis — Tue, 04 May 2010 23:00:00 +0100

A nonionic surfactant MEKC method with LIF detection was developed for the simultaneous determination of memantine, an anti-Alzheimer's disease agent, and amantadine, an anti-Parkinson's disease drug, in human plasma. Before analysis, the plasma samples were pretreated by liquid-liquid extraction with ethyl acetate, and derivatized with 6-carboxyfluorescein N-hydroxysuccinimide ester. The chemical derivatization is performed with 6-carboxyfluorescein N-hydroxysuccinimide ester in ACN - 5 mM pH 9.0 borate buffer (40:60, v/v) at 35°C for 3 h. After the derivatization reaction, hydrodynamic injection (0.5 psi, 8 s) was used to introduce the derivatized solution, and the separation was performed in borate buffer (30 mM, pH 9.5) with the nonionic surfactant Brij-35® (0.07%, w/v); the separati...

Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield.

Brain Research — Fri, 30 Apr 2010 23:00:00 +0100

Authors: Wu GM, Hou XY Amyloid-beta peptide (Abeta) plays a causal role in the pathogenesis of Alzheimer's disease (AD). To elucidate the mechanisms underlying the over-activation of NMDA receptors in AD, we investigated the alteration of NR2A tyrosine phosphorylation after intracerebroventricular infusion of Abeta25-35 oligomers. Abeta25-35 treatment resulted in the elevated tyrosine phosphorylation of NR2A in rat hippocampal CA1 subfield and facilitated the interactions of NR2A or PSD-95 with Src kinases. PP2, a specific inhibitor of Src family protein tyrosine kinases (SrcPTKs), not only attenuated the Abeta25-35-induced increases in the tyrosine phosphorylation of NR2A and in the associations among Src, NR2A, and PSD-95, but also protected against neuronal loss in the CA1 region. P...